keyword
https://read.qxmd.com/read/38533444/small-size-big-problems-insights-and-difficulties-in-prenatal-diagnosis-of-fetal-microcephaly
#1
REVIEW
Leila Haddad, Efrat Hadi, Zvi Leibovitz, Dorit Lev, Yoseph Shalev, Liat Gindes, Tally Lerman-Sagie
Microcephaly is a sign, not a diagnosis. Its incidence varies widely due to the differences in the definition and the population being studied. It is strongly related to neurodevelopmental disorders. Differences in definitions and measurement techniques between fetuses and newborns pose a great challenge for the diagnosis and prognostication of fetal microcephaly. A false positive diagnosis can result (in countries where it is legal) in erroneous termination of pregnancy, where a false negative diagnosis might lead to the birth of a microcephalic newborn...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38533284/utility-of-colour-flow-doppler-ultrasonography-to-differentiate-gestational-transient-thyrotoxicosis-and-graves-disease-in-pregnancy
#2
JOURNAL ARTICLE
Vijay Sheker Reddy Danda, Piyush Lodha, Srinivas Rao Paidipally, Sandeep Reddy Devireddy
INTRODUCTION: Accurate diagnosis of the etiology of thyrotoxicosis in pregnancy is important to guide appropriate treatment. The role of thyroid blood flow velocities by color Doppler to differentiate between Graves' disease (GD) in pregnancy and gestational transient thyrotoxicosis (GTT) is not well explored. This study evaluated inferior thyroid artery (ITA)-peak systolic velocity (PSV) as a marker for differential diagnosis of thyrotoxicosis in pregnancy. METHODS: Fifty-six pregnant patients with thyrotoxicosis (30 with GTT and 26 with GD) along with 30 age-matched healthy euthyroid pregnant subjects were enrolled...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533137/torsion-in-uterus-an-obstetrical-and-gynaecological-emergency
#3
REVIEW
Sukanya Singh, Surekha Tayade, Drashti Patel
Uterine torsion is defined as torsion of the uterus along its longitudinal axis greater than 45 degrees. It is observed in all age groups of the reproductive period, in all parity groups, and at all stages of pregnancy. Torsion from 60 degrees to 720 degrees has been described. It is not possible to clarify why it occurs, but numerous abnormalities have appeared with uterine torsion. It is a rare complication that can result in placental abruption and intrauterine foetal death. Pregnancy, giant fibroids, and ovarian cysts are among the most common causes...
February 2024: Curēus
https://read.qxmd.com/read/38532548/to-know-or-not-to-know-effect-of-third-trimester-sonographic-fetal-weight-estimation-on-outcomes-of-large-for-gestational-age-neonates
#4
JOURNAL ARTICLE
Gil Zeevi, Noam Regev, Chen Key-Segal, Asaf Romano, Ohad Houri, Or Bercovich, Eran Hadar, Alexandra Berezowsky
OBJECTIVE: The aim of the present study was to evaluate the impact of late third-trimester sonographic estimation of large for gestational age fetuses on pregnancy management and selected fetal and maternal adverse outcomes. METHODS: A retrospective cohort study was conducted in a tertiary, university-affiliated medical center between 2015 and 2019. All singleton large-for-gestational-age neonates born during this period were included. The cohort was divided into two groups: neonates for whom fetal weight was estimated on late third trimester (<14 days before delivery) sonography and neonates with no recent fetal weight estimation...
March 26, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38532440/anatomical-and-functional-changes-of-the-fetal-adrenal-gland-in-intrauterine-growth-restriction
#5
JOURNAL ARTICLE
Serena Martinelli, Alessandro Rolfo, Carlotta Pace, Letizia Canu, Anna Maria Nuzzo, Domenica Giuffrida, Pietro Gaglioti, Tullia Todros
OBJECTIVE: The aim of this study was to demonstrate the establishment of adrenal sparing in intrauterine growth restricted (IUGR) human fetuses. IUGR fetuses are a subgroup of small for gestational age (SGA) fetuses that are unable to reach their own growth potential because of chronic hypoxia and undernutrition. We hypothesized that in IUGR fetuses the adrenal gland is relatively larger and secretion of noradrenaline (NA), adrenaline (A), and cortisol is increased. STUDY DESIGN: This is a prospective observational study including 65 singleton pregnancies (42 IUGR and 23 controls)...
March 26, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38531559/first-intrauterine-transfusion-in-rh-isoimmunised-triplet-pregnancy
#6
JOURNAL ARTICLE
Vandana Bansal, Akshaykumar Babanrao Gangurde, Amol Pawar, Forum Shah
G3P2L1, 28+4 weeks of gestation rhesus (Rh) isoimmunised pregnant women, was referred with trichorionic triamniotic triplet pregnancy with Rh antibody titres of 1:32. Nuchal translucency and anomaly scan were within normal limits with no major malformation for any of the fetuses. Obstetric colour Doppler with middle cerebral artery peak systolic volume revealed foetal anaemia in all three fetuses having velocities corresponding to around 1.5 times the median. Decision of intrauterine transfusion of blood to all three fetuses was taken...
March 25, 2024: BMJ Case Reports
https://read.qxmd.com/read/38530405/integrative-network-analysis-of-differentially-methylated-regions-to-study-the-impact-of-gestational-weight-gain-on-maternal-metabolism-and-fetal-neonatal-growth
#7
JOURNAL ARTICLE
Perla Pizzi Argentato, João Victor da Silva Guerra, Liania Alves Luzia, Ester Silveira Ramos, Mariana Maschietto, Patrícia Helen de Carvalho Rondó
Integrative network analysis (INA) is important for identifying gene modules or epigenetically regulated molecular pathways in diseases. This study evaluated the effect of excessive gestational weight gain (EGWG) on INA of differentially methylated regions, maternal metabolism and offspring growth. Brazilian women from "The Araraquara Cohort Study" with adequate pre-pregnancy body mass index were divided into EGWG (n=30) versus adequate gestational weight gain (AGWG, n=45) groups. The methylome analysis was performed on maternal blood using the Illumina MethylationEPIC BeadChip...
2024: Genetics and Molecular Biology
https://read.qxmd.com/read/38528322/prevalence-and-prenatal-diagnosis-of-congenital-eye-anomalies-a-population-based-study
#8
JOURNAL ARTICLE
Corentin Maillet, Lucie Guilbaud, Isabelle Monier, Babak Khoshnood, Emmanuel Bui Quoc, Anais Dugas, Nathalie Lelong, Jean-Marie Jouannic
OBJECTIVE: To estimate the prevalence and trend of congenital eye anomalies (CEAs) and the rate of prenatal diagnosis over a 10-year period. DESIGN: Retrospective population-based registry study. SETTING: All maternity units in Paris, France, from 2010 to 2020. POPULATION: A cohort of 115 cases of CEA detected among all live births or stillbirths, after 22 weeks of gestation, and terminations of pregnancy. METHODS: The total prevalence of CEAs and prevalence of each specific CEA were calculated using 95% Poisson exact confidence intervals...
March 25, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/38527993/fetal-acrania-diagnosed-at-17-weeks-of-gestation-by-2d%C3%A2-3d-ultrasound-a-case-report-and-literature-review
#9
JOURNAL ARTICLE
Bogdan Ioan Ştefănescu, Tiberiu Ioan Mihalache, Georgiana Bianca Constantin, George Ţocu, Miruna Maria Ştefănescu, Roxana Elena Bogdan Goroftei
Acrania is a fetal malformation characterized by complete or partial absence of the calvaria above the orbits and supraciliary ridge. No exact mechanism is demonstrated for this anomaly but disturbances in mesenchymal migration during the fourth week of development are the most documented. The key sonographic features of acrania are absent calvaria and dorsally bulging brain (Mickey Mouse head). Due to the normal process of ossification of cranial bones, the diagnosis can be established only after 11 weeks of gestation...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527602/the-association-between-discordant-umbilical-arterial-resistance-in-growth-restricted-fetuses-and-adverse-outcomes
#10
JOURNAL ARTICLE
Misgav Rottenstreich, Swati Agrawal, Homero Flores Mendoza, Sarah D McDonald, Bryon DeFrance, Jon Fr Barrett, Eran Ashwal
BACKGROUND: Assessing the umbilical artery pulsatility index (UA PI) via Doppler measurements plays a critical role in evaluating fetal growth impairment. This study aims to investigate perinatal outcomes associated with discordant PIs of umbilical arteries (UAs) in growth-restricted fetuses. METHODS: In this retrospective cohort study, all singleton pregnancies were included if their estimated fetal weight (EFW) and/or abdominal circumference (AC) fell below the 10th percentile for gestational age (2017-2022)...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38525638/trisomy-21-screening-with-%C3%AE-lpha-software-and-the-fetal-medicine-foundation-algorithm
#11
JOURNAL ARTICLE
L Pistorius, C A Cluver, I Bhorat, L Geerts
BACKGROUND: Screening for trisomy 21 provides pregnant women with accurate risk information. Different algorithms are used to screen for trisomy 21 in South Africa (SA). The Fetal Medicine Foundation (FMF) provides software to screen for trisomy 21 in the first trimester by ultrasound or a combination of ultrasound and biochemistry (combined screening), and requires regular and stringent quality control. With αlpha software, first trimester combined screening and screening with biochemistry alone in the first or second trimester are possible...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38523989/successful-fetal-reduction-in-early-second-trimester-series-of-three-cases-conceived-with-infertility-treatment
#12
Prachi A Ughade, Deepti Shrivastava
This case series explores three instances of a successful fetal reduction in early second-trimester pregnancies conceived through infertility treatments. The patients, all admitted to a central Indian tertiary care hospital, underwent assisted reproductive technologies such as in vitro fertilization (IVF) or intrauterine insemination (IUI). Faced with triplet pregnancies, fetal reduction was made to mitigate risks and enhance maternal and fetal well-being. The reduction procedures, conducted either transvaginally or transabdominally under continuous ultrasound guidance, resulted in the cessation of targeted fetal heart activity and motility...
February 2024: Curēus
https://read.qxmd.com/read/38522504/robotic-assisted-uterine-transposition-followed-by-anatomic-pelvic-repositioning-for-a-patient-with-intramural-fibroids-and-rectal-cancer
#13
JOURNAL ARTICLE
Megan E Gornet, Mindy S Christianson, Rebecca L Stone
OBJECTIVE: To report the first described case of robotic-assisted utero-ovarian transposition followed by anatomic repositioning in the pelvis and cervico-vaginal anastomosis in a woman with uterine fibroids, which was performed for fertility preservation in the context of pelvic radiation for rectal cancer. DESIGN: Description of technique and live-action narrated surgical footage showing uterine transposition and repositioning. SUBJECT(S): 36 year-old woman with a new diagnosis of cT3N2M0 rectal adenocarcinoma, planned for neoadjuvant chemotherapy and pelvic radiation, who desired fertility preservation permissive of future pregnancy...
March 22, 2024: Fertility and Sterility
https://read.qxmd.com/read/38522306/interstitial-ectopic-pregnancy-a-rare-case-report
#14
Majd Sabbagh, Nehad Othman, Salah Chaikha, Rehab Sukkar, Amal alToto, Lina alQudsi
INTRODUCTION: Interstitial pregnancies are a rare form of ectopic pregnancy with life threatening consequences. Thus, the aim of this report is to shed light on the importance of early diagnosis for optimal outcomes. CASE PRESENTATION: Herein, we present a case of an interstitial ectopic pregnancy in a 31-year-old Syrian female who presented only with mild non-specific abdominal pain. The ultrasound showed a gestational sac in the right horn of the uterus non-communicating with the endometrial cavity suggesting an interstitial ectopic pregnancy...
March 18, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38521232/reproductive-and-obstetric-outcomes-after-treatment-of-retained-products-of-conception-hysteroscopic-removal-versus-ultrasound-guided-electric-vacuum-aspiration-a-prospective-follow-up-study
#15
JOURNAL ARTICLE
Liselot P Wagenaar, Wouter L J van Vugt, Aleida G Huppelschoten, Celine M Radder, Louisette W Peters, Steven Weyers, Steffi van Wessel, Benedictus C Schoot, Tjalina W O Hamerlynck, Huib A van Vliet
BACKGROUND: Traditionally, curettage is the most widely performed surgical intervention used to remove retained products of conception. However, hysteroscopic removal is increasingly performed as an alternative due to the potentially lower risk of intrauterine adhesions and higher rates of complete removal. Until recently, studies comparing curettage with hysteroscopic removal regarding reproductive and obstetric outcomes were limited, and data conflicting. OBJECTIVE: To study reproductive and obstetric outcomes in women wishing to conceive after removal of retained products of conception by hysteroscopy or ultrasound-guided electric vacuum aspiration...
March 21, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38520306/the-value-of-ultrasound-parameters-in-predicting-the-efficacy-of-transabdominal-ultrasound-guided-suction-curettage-alone-in-the-treatment-of-cesarean-scar-pregnancy
#16
JOURNAL ARTICLE
Chunqiao Zhou, Xinyan Li, Yu'ning Mo, Fangtao Wei
OBJECTIVE: To investigate the value of ultrasound parameters in assessing the efficacy of transabdominal ultrasound (TAUS)-guided suction curettage alone for cesarean scar pregnancy (CSP). METHODS: Secondary retrospective analysis of a prospective study consisted of 137 women diagnosed with CSP who were performed TAUS-guided suction curettage alone for the first time at Maternity and Child Health Care of Guangxi Zhuang Autonomous Region in China. Prior to surgery, an ultrasound examination was conducted...
March 23, 2024: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/38519904/association-of-maternal-nutritional-status-and-small-for-gestational-age-neonates-in-peri-urban-communities-of-karachi-pakistan-findings-from-the-prisma-study
#17
JOURNAL ARTICLE
Sobia Ambreen, Nida Yazdani, Abdul Salam Alvi, Muhammad Farrukh Qazi, Zahra Hoodbhoy
BACKGROUND: Early pregnancy nutritional status can be associated with adverse birth outcomes such as small-for-gestational age (SGA) and low birth weight (LBW). BMI (Body Mass Index) and MUAC (Mid-upper arm circumference) are easy to use assessments and are indicative of the pre-pregnancy nutritional status if obtained in the first trimester. This study primarily assesses the association of maternal nutritional status using BMI and MUAC with SGA in a community-based cohort of Pakistani women...
March 22, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38518425/association-of-maternal-obesity-with-growth-of-fetal-fractional-limb-volume
#18
JOURNAL ARTICLE
Satoru Ikenoue, Yohei Akiba, Ryota Ishii, Toshimitsu Otani, Yoshifumi Kasuga, Mamoru Tanaka
BACKGROUND: Maternal obesity influences birth weight and newborn adiposity. Fetal fractional limb volume has recently been introduced as a useful parameter for the proxy of fetal adiposity. However, the association between maternal adiposity and the growth of fetal fractional limb volume has not been examined. AIMS: To investigate the association of maternal pre-pregnancy BMI with the growth of fetal fractional limb volume. STUDY DESIGN: Prospective cohort study...
March 19, 2024: Early Human Development
https://read.qxmd.com/read/38516427/pregnancy-with-a-bicornuate-uterus-complicated-by-placenta-percreta-and-intraperitoneal-hemorrhage
#19
Reem Talal Almehzaa, Amala Sunder, Nayla Bushaqer
Uterine malformations significantly affect the reproduction process, and such anomalies can affect the progression and prognosis of a pregnancy. A bicornuate uterus is a rare congenital uterine anomaly that occurs due to a defect in the fusion of Müllerian ducts. It is associated with severe maternal and fetal complications, such as uterine rupture, vascular-related pathologies, preterm labor and birth, recurrent early or late loss of pregnancy, and fetal growth restriction. In such scenarios, close monitoring and ultrasound screening are needed to prevent obstetric complications...
February 2024: Curēus
https://read.qxmd.com/read/38516411/ovarian-tissue-transplantation-10-years-of-experience-at-the-bologna-university
#20
JOURNAL ARTICLE
Raffaella Fabbri, Rossella Vicenti, Valentina Magnani, Roberto Paradisi, Lucia De Meis, Diego Raimondo, Alessandro Arena, Stefano Venturoli, Antonio Raffone, Arianna Raspollini, Renato Seracchioli
OBJECTIVE: The efficiency of ovarian tissue transplantation (OTT) was established in terms of ovarian function recovery (95% of cases), number of live births (over 200 worldwide to date) and induction of puberty. Unfortunately, the lack of international registries and the fact that many centers have not yet reported their outcomes, lead to poor knowledge of the exact fertility data. The aim of the study is to describe our experience with OTT to restore ovarian function and fertility. METHODS: This study was designed as a single-center, observational, retrospective, cohort study that includes women who underwent OTT between December 2012 and June 2023 at our center...
2024: Frontiers in Endocrinology
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