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https://www.readbyqxmd.com/read/29454287/the-sedative-activity-of-flavonoids-from-passiflora-quadrangularis-is-mediated-through-the-gabaergic-pathway
#1
Andressa Corneo Gazola, Geison Modesti Costa, Silvana Maria Zucolotto, Leonardo Castellanos, Freddy Alejandro Ramos, Thereza Christina Monteiro de Lima, Eloir Paulo Schenkel
The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2''-O-xyloside, vitexin-2''-O-glucoside, orientin-2''-O-xyloside and orientin-2''-O-glucoside...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454285/pou5f1b-promotes-hepatocellular-carcinoma-proliferation-by-activating-akt
#2
Yaozhen Pan, Lei Zhan, Ling Chen, Hong Zhang, Chengyi Sun, Chungen Xing
Hepatocellular carcinoma (HCC) is one of the most common tumors, so far, there still aren't good therapeutic methods. Looking for new targets makes a top priority. In this study, we found a OCT4 pseudogene, POU5F1B was significantly upregulated in HCC cells and tissues, patients with high POU5F1B had shorter survival time compared to patients with low POU5F1B expression. POU5F1B overexpression promoted HCC proliferation, while its knockdown inhibited HCC proliferation determined by MTT assay, soft agar growth assay, BrdU incorporation assay, and cell cycle assay...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454281/probing-the-%C3%AE-pocket-of-the-active-site-of-human-liver-glycogen-phosphorylase-with-3-c-%C3%AE-d-glucopyranosyl-5-4-substituted-phenyl-1-2-4-triazole-inhibitors
#3
Efthimios Kyriakis, Theodora G A Solovou, Sándor Kun, Katalin Czifrák, Béla Szőcs, László Juhász, Éva Bokor, George A Stravodimos, Anastassia L Kantsadi, Demetra S M Chatzileontiadou, Vassiliki T Skamnaki, László Somsák, Demetres D Leonidas
Human liver glycogen phosphorylase (hlGP), a key enzyme in glycogen metabolism, is a valid pharmaceutical target for the development of new anti-hyperglycaemic agents for type 2 diabetes. Inhibitor discovery studies have focused on the active site and in particular on glucopyranose based compounds with a β-1 substituent long enough to exploit interactions with a cavity adjacent to the active site, termed the β-pocket. Recently, C-β-d-glucopyranosyl imidazoles and 1, 2, 4-triazoles proved to be the best known glucose derived inhibitors of hlGP...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29454272/dealing-with-the-nucleus-during-cell-migration
#4
REVIEW
Francisco J Calero-Cuenca, Cátia S Janota, Edgar R Gomes
The position of the nucleus within cells is a key event during cell migration. The movement and positioning of the nucleus strongly impacts cell migration. Notably, the last two years largely contributed to emphasise the dynamicity of the nucleus-cytoskeleton interactions that occur during cell migration. Nuclei are under continuous tension from opposing intracellular forces and its tether to the cytoskeleton can be regulated at different levels. Interestingly, it was showed how nuclear positioning is highly related to cell function...
February 14, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29454270/cadmium-induced-stress-response-of-phanerochaete-chrysosporium-during-the-biodegradation-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47
#5
Mi Feng, Hua Yin, Yajuan Cao, Hui Peng, Guining Lu, Zehua Liu, Zhi Dang
Cd-induced stress response of Phanerochaete chrysosporium during the biodegradation of BDE-47 was investigated in this study, with the goal of elucidating the tolerance behavior and the detoxification mechanisms of P. chrysosporium to resist the Cd stress in the course of BDE-47 biodegradation, which has implications for expanding the application of P. chrysosporium in the bioremediation of Cd and BDE-47 combined pollution. The results suggested that single BDE-47 exposure did not induce obvious oxidative stress in P...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454261/frequency-of-somatic-tp53-mutations-in-combination-with-known-pathogenic-mutations-in-colon-adenocarcinoma-non-small-cell-lung-carcinoma-and-gliomas-as-identified-by-next-generation-sequencing
#6
Zahra Shajani-Yi, Francine B de Abreu, Jason D Peterson, Gregory J Tsongalis
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer. It encodes p53, a DNA-binding transcription factor that regulates multiple genes involved in DNA repair, metabolism, cell cycle arrest, apoptosis, and senescence. TP53 is associated with human cancer by mutations that lead to a loss of wild-type p53 function as well as mutations that confer alternate oncogenic functions that enable them to promote invasion, metastasis, proliferation, and cell survival. Identifying the discrete TP53 mutations in tumor cells may help direct therapies that are more effective...
February 13, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29454252/human-papillomavirus-detection-using-pcr-and-atr-ftir-for-cervical-cancer-screening
#7
Taciana Rymsza, Eliane Aline Ribeiro, Luis Felipe das Chagas E Silva de Carvalho, Tanmoy Bhattacharjee, Renata de Azevedo Canevari
The human papillomavirus (HPV) genital infection is considered one of the most common sexually transmitted diseases worldwide, and has been associated with cervical cancer. The objective of this study was to investigate the efficacy of the diagnostic methods: polymerase chain reaction (PCR) and Fourier transform infrared (FTIR) equipped with an ATR (Attenuated Total Reflectance) unit (Pike Tech) spectroscopy, to diagnose HPV infection in women undergoing gynecological examination. Seventeen patients (41.46%) of the 41 patients analyzed were diagnosed with exophytic/condyloma acuminate lesions by clinical analysis, 29 patients (70...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#8
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454228/obturator-internus-muscle-abscess-caused-by-methicillin-resistant-staphylococcus-aureus-in-an-adult-a-case-report
#9
Akinori Maeda, Isaku Saku, Shotaro Kanda, Kazuo Saita, Toru Akiyama
INTRODUCTION: Obturator internus muscle (OIM) abscess is a rare condition, usually affecting children after trauma or muscular effort. Blood cultures always yield positive findings, with Staphylococcus aureus being the most common culprit. There are few reports in adults. PRESENTATION OF CASE: We report a case of OIM abscess in an adult. A 24-year-old male was admitted to our hospital because of right hip pain and fever. He was diagnosed with OIM abscess, and methicillin-resistant Staphylococcus aureus (MRSA) was detected on bacterial examination...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29454216/non-linear-effects-of-mean-temperature-and-relative-humidity-on-dengue-incidence-in-guangzhou-china
#10
Xiaocheng Wu, Lingling Lang, Wenjun Ma, Tie Song, Min Kang, Jianfeng He, Yonghui Zhang, Liang Lu, Hualiang Lin, Li Ling
BACKGROUND: Dengue fever is an important infectious disease in Guangzhou, China; previous studies on the effects of weather factors on the incidence of dengue fever did not consider the linearity of the associations. METHODS: This study evaluated the effects of daily mean temperature, relative humidity and rainfall on the incidence of dengue fever. A generalized additive model with splines smoothing function was performed to examine the effects of daily mean, minimum and maximum temperatures, relative humidity and rainfall on incidence of dengue fever during 2006-2014...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454200/effect-of-clonal-integration-on-nitrogen-cycling-in-rhizosphere-of-rhizomatous-clonal-plant-phyllostachys-bissetii-under-heterogeneous-light
#11
Yang Li, Jing-Song Chen, Ge Xue, Yuanying Peng, Hui-Xing Song
Clonal integration plays an important role in clonal plant adapting to heterogeneous habitats. It was postulated that clonal integration could exhibit positive effects on nitrogen cycling in the rhizosphere of clonal plant subjected to heterogeneous light conditions. An in-situ experiment was conducted using clonal fragments of Phyllostachys bissetii with two successive ramets. Shading treatments were applied to offspring or mother ramets, respectively, whereas counterparts were treated to full sunlight. Rhizomes between two successive ramets were either severed or connected...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454182/the-positive-effect-of-venlafaxine-on-central-motor-conduction
#12
Chunyong Li, Fuda Liu, Haiyan Peng, Yongjun Huang, Xuezhu Song, Qi Xie, Yingkai Li, Yan Liu
OBJECTIVES: Using the triple stimulation technique (TST) and conventional transcranial magnetic stimulation (TMS), this study was designed to investigate the effect of venlafaxine on central motor conduction in healthy adults. PATIENTS AND METHODS: In this crossover, self-controlled trial, eight healthy adult volunteers were randomly divided into groups A and B. In group A, the volunteers were administered 1 venlafaxine capsule once daily for 7 consecutive days, followed by a 3-day break...
February 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29454177/tobacco-harm-perceptions-and-use-among-sexual-and-gender-minorities-findings-from-a-national-sample-of-young-adults-in-the-united-states
#13
Ollie Ganz, Amanda L Johnson, Amy M Cohn, Jessica Rath, Kimberly Horn, Donna Vallone, Andrea C Villanti
INTRODUCTION: In the United States, the prevalence of tobacco use among sexual and gender minorities (SGM) is higher compared to their non-SGM counterparts. Tobacco harm perceptions have gone largely unexamined as a potential mechanism supporting disproportionate tobacco use among this population. The purpose of this study was to examine differences between SGM and non-SGM young adults in harm perceptions of various tobacco products and tobacco use behavior and whether low tobacco-related harm perceptions moderate the relationship between identifying as a SGM and tobacco use behavior...
January 31, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29454156/the-glun2b-subunit-represents-a-major-functional-determinant-of-nmda-receptors-in-human-induced-pluripotent-stem-cell-derived-cortical-neurons
#14
Ioana Neagoe, Chang Liu, Alexander Stumpf, Yanmei Lu, Dongping He, Ross Francis, Jun Chen, Paul Reynen, Moulay Hicham Alaoui-Ismaili, Hirokazu Fukui
Abnormal signaling pathways mediated by N-methyl-d-aspartate receptors (NMDARs) have been implicated in the pathogenesis of various CNS disorders and have been long considered as promising points of therapeutic intervention. However, few efforts have been previously described concerning evaluation of therapeutic modulators of NMDARs and their downstream pathways in human neurons with endogenous expression of NMDARs. In the present study, we assessed expression, functionality, and subunit composition of endogenous NMDARs in human induced pluripotent stem cell (hiPSC)-derived cortical neurons (iCell Neurons and iCell GlutaNeurons)...
February 8, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29454146/matching-trends-for-the-fellowship-in-minimally-invasive-gynecologic-surgery-fmigs-since-participation-in-the-national-residency-match-program-nrmp
#15
Maria V Vargas, Magdy P Milad
OBJECTIVE: To describe the level of interest in the fellowship in minimally invasive gynecologic surgery (FMIGS) using data from National Residency Match Program (NRMP) over the past 4 years. DESIGN: Retrospective report (Canadian Task Force Classification II-2) SETTING: Publically reported data from the NRMP PARTICIPANTS: Applicants using the NRMP to match into fellowship training. INTERVENTIONS: Reporting matching trends for the gynecologic surgical subspecialty programs starting in 2014, when the FMIGS programs started participating in the NRMP...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29454121/complications-of-impulse-generator-exchange-surgery-for-deep-brain-stimulation-a-single-centre-retrospective-study
#16
Ann-Kristin Helmers, Isabel Lübbing, Falk Birkenfeld, Karsten Witt, Michael Synowitz, Hubertus Maximilian Mehdorn, Daniela Falk
OBJECTIVE: Non-rechargeable deep brain stimulation (DBS) impulse generators (IG) with a low or empty battery status require surgical IG exchange several years after initial implantation. Complication rates in patients undergoing DBS surgery range from 7.6% to 25.3%. The aim of this study was to investigate the complication rates after IG exchange surgery and to identify risk factors for complications. METHODS: We retrospectively analysed complications following IG exchange surgery from 2008 to 2015 in a single-centre university hospital setting...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454119/anatomical-study-of-the-nutrient-foramina-of-the-posterior-axis-with-application-to-c2-pedicle-screw-placement
#17
Tamir Tawfik, Joe Iwanaga, Emre Yilmaz, Paul Choi, Charlotte Wilson, Emily Simonds, Jared J Marks, Haynes L Harkey, Rod J Oskouian, R Shane Tubbs
OBJECTIVE: Pedicle screws placed into C2 necessitate a thorough understanding of this bone's unique anatomy. Although multiple landmarks and measurements have been used by surgeons, these are often varied in the literature with no consensus. Herein, we studied one recently proposed landmark using the nutrient foramina of the posterior aspect of C2 for pedicle screw placement. METHODS: On 19 (38 sides) C2 dry bone specimens, the presence, size, location, and distance from the midline of the nutrient foramina found at the junction between the isthmus and lamina were documented and measured...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454085/effects-of-orientation-and-differential-reinforcement-ii-transitivity-and-transfer-across-five-member-sets
#18
Micah Amd, Marlon A de Oliveira, Denise A Passarelli, Livia C Balog, Julio C de Rose
A recent report by Amd and colleagues (2017) demonstrated that orienting towards successively presented stimulus-stimulus pairs yielded significantly more transitive relations then when those same pairs were differentially reinforced following training for three, 3-member stimulus sets. We build on that work in four important ways. First, transitivity yields produced by Pavlovian and instrumental procedures were compared following training for three 5-member sets (A1-B1-C1-D1-E1, A2-B2-C2-D2-E2, A3-B3-C3-D3-E3), where the 'A' stimuli were emotional faces and all remaining stimuli were nonsense words...
February 14, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29454079/a-novel-metric-that-quantifies-risk-stratification-for-evaluating-diagnostic-tests-the-example-of-evaluating-cervical-cancer-screening-tests-across-populations
#19
Hormuzd A Katki, Mark Schiffman
Our work involves assessing whether new biomarkers might be useful for cervical-cancer screening across populations with different disease prevalences and biomarker distributions. When comparing across populations, we show that standard diagnostic accuracy statistics (predictive values, risk-differences, Youden's index and Area Under the Curve (AUC)) can easily be misinterpreted. We introduce an intuitively simple statistic for a 2 × 2 table, Mean Risk Stratification (MRS): the average change in risk (pre-test vs...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29454078/looking-for-capacities-rather-than-vulnerabilities-the-moderating-effect-of-health-assets-on-the-associations-between-adverse-social-position-and-health
#20
Mathieu Roy, Mélanie Levasseur, Isabelle Doré, France St-Hilaire, Bernard Michallet, Yves Couturier, Danielle Maltais, Bengt Lindström, Mélissa Généreux
To increase capacities and control over health, it is necessary to foster assets (i.e. factors enhancing abilities of individuals or communities). Acting as a buffer, assets build foundations for overcoming adverse conditions and improving health. However, little is known about the distribution of assets and their associations with social position and health. In this study, we documented the distribution of health assets and examined whether these assets moderate associations between adverse social position and self-reported health...
February 14, 2018: Preventive Medicine
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