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Nicole Meyer, Ana Claudia Zenclussen
Mast cells (MCs) are most known because of their prominent role in allergy. In the last years, however, it has become clear that they have pleiotropic functions and a high adaptability to the milieu. This review focuses on negative and positive roles of MCs within the body with particular emphasis on their participation in reproductive processes.
June 19, 2018: American Journal of Reproductive Immunology: AJRI
Daniel L Rolnik, Fabricio da Silva Costa, Daljit Sahota, Jon Hyett, Andrew McLennan
AIM: To assess the quality of mean uterine artery pulsatility index (UtAPI) measurement in a first trimester pre-eclampsia screening program. METHODS: Consecutive patients attending first trimester screening for fetal chromosomal abnormalities also had combined screening for pre-eclampsia based on the Fetal Medicine Foundation (FMF) algorithm, in a large practice in Sydney, Australia, from May 2014 to February 2017. Distributions of mean UtAPI multiples of the median (MoM) on the logarithmic scale were plotted in relation to the normal median with 95% confidence interval (CI) for each operator and for each month...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
Carla Isabelly Rodrigues-Fernandes, Lucas Lacerda de Souza, Sara Ferreira Dos Santos Costa, André Myller Barbosa Silva, Hélder Antônio Rebelo Pontes, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Peter A Brennan, Felipe Paiva Fonseca
BACKGROUND: Plasmablastic lymphoma (PBL) is a high grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. PURPOSE: To integrate the available data on oral PBL to determine its clinico-pathological features and to identify potential prognostic factors. METHODS: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018...
June 19, 2018: Journal of Oral Pathology & Medicine
Joanna E Kontaraki, Maria E Marketou, George E Kochiadakis, Spyros Maragkoudakis, John Konstantinou, Panos E Vardas, Fragiskos I Parthenakis
Long non-coding RNAs (lncRNAs) participate in the modulation of cardiac hypertrophy and they represent potential therapeutic targets in cardiovascular disease. We investigated the expression profiles of selected lncRNAs in peripheral blood mononuclear cells of patients with essential hypertension in relation to left ventricular hypertrophy. We assessed the expression levels of the lncRNAs MHRT, FENDRR and CARMEN using real-time reverse transcription polymerase chain reaction. Hypertensive patients showed significantly higher MHRT, FENDRR and CARMEN expression levels compared with healthy controls...
June 19, 2018: Clinical and Experimental Pharmacology & Physiology
S du Preez, S L Raidal, G S Doran, M Prescott, K J Hughes
BACKGROUND: Exhaled breath condensate (EBC) analysis is a non-invasive method to assess the lower respiratory tract. In humans, EBC hydrogen peroxide (H2 O2 ), pH and leukotriene B4 (LTB4 ) are useful for detection and monitoring of inflammatory lung diseases, including asthma. OBJECTIVES: To determine associations between EBC biomarkers and cytological and endoscopic definitions of lower airway inflammation whilst controlling for sampling and environmental variables...
June 19, 2018: Equine Veterinary Journal
Emma J Stinson, Marisol Perez, Tara K Ohrt, Anna Von Schell, Amanda B Bruening
OBJECTIVE: The current study sought to investigate whether credibility, expectancy, and acceptability of the Body Project is impacted by level of disordered eating pathology and whether perceived credibility, expectancy, and acceptability impacts treatment outcomes. METHODS: The sample included 170 undergraduate women from a large public university. Participants completed self-report questionnaires on perceived credibility, expectancy, treatment acceptability, and disordered eating measures...
June 19, 2018: Journal of Clinical Psychology
Karina P Abrahao, David M Lovinger
KEY POINTS: Classifying different subtypes of neurons in deep brain structures is a challenge and is crucial to better understanding brain function. Understanding the diversity of neurons in the Globus Pallidus, a brain region positioned to influence afferent and efferent information processing within basal ganglia, could help to explain a variety of brain functions. We present a classification of neurons from the GP using electrophysiological data from wild type mice and confirmation using transgenic mice...
June 19, 2018: Journal of Physiology
Jeffrey Rohrbough, Hong-Ngan Nguyen, Fred S Lamb
We utilized plasma membrane-localized ClC-3 to investigate relationships between steady-state transport current (ISS ), gating charge (Q) movement, and cytoplasmic alkalization rate. ClC-3 exhibited lower transport efficiency than ClC-5, as reflected by a larger Q/ISS ratio, but an indistinguishable Cl- /H+ coupling ratio. External SCN- reduced H+ transport rate and uncoupled anion/H+ exchange by 80-90%. "Gluext " removal (E224A) eliminated Q and abolished H+ transport. We hypothesized that M531 impedes "water-wire" H+ transfer from the cytoplasm to E224...
June 19, 2018: Journal of Physiology
Jordan Greer
Does fine-scale variation in the aposematic coloration of the six-spot burnet moth, Zygaena filipendulae, reflect its degree of toxicity? Briolat et al. (2018) find that most color metrics do not have a significant positive association (or sometimes curiously a negative association) to the amount of toxins present in Z. filipendulae. Surprisingly, effects are more pronounced in females, which exhibit a decrease in color saturation and wing spot size in accordance with greater concentrations of cyanogenic glucosides...
June 19, 2018: Evolution; International Journal of Organic Evolution
L-C Pan, H-Y Xiao, W-J Yin, Z Lin
OBJECTIVE: Pathogenesis and progression of liver cancer are correlated with inflammatory response and estrogen level. 17β-estradiol dehydrogenase IV (HSD17B4) is highly expressed in human liver cancer tissues. HSD17B4 participates in liver cancer cell proliferation via suppressing estradiol (E2) activity. This study generated a rat liver cancer model, on which the correlations between HSD17B4 and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), proliferating cell nucleus antigen (PCNA) expression were analyzed...
June 2018: European Review for Medical and Pharmacological Sciences
D-B Liu, H-P Zhang, K Yu, Q-B Lu, Z-F Zhu
OBJECTIVE: To study the change rules of inflammatory factors in cerebrospinal fluid (CSF) and serum of patients with viral meningitis. PATIENTS AND METHODS: 742 patients with suspected viral meningitis admitted to Department of Neurosurgery in our hospital from August 2012 to May 2016 were selected as research objects and retrospectively analyzed. 536 patients were diagnosed with viral meningitis by CSF with the lumbar puncture and brain computed tomography (CT), while the other 206 patients were diagnosed with non-infectious nervous system disease, as the control group...
June 2018: European Review for Medical and Pharmacological Sciences
W-B Yang, W-P Zhang, J-L Shi, J-W Wang
OBJECTIVE: The aim of the present study was to investigate clinical significances and biological roles of miR-4299 in non-small cell lung cancer (NSCLC) PATIENTS AND METHODS: Expression of miR-4299 in NSCLC tissues and matched non-tumor tissues was determined by quantitative real-time PCR (qRT-PCR). The correlations between miR-4299 expression and clinicopathological characteristics and prognosis were also analyzed. MTT assay and Transwell assay were performed to determine the proliferation, migration and invasion...
June 2018: European Review for Medical and Pharmacological Sciences
H Xu, Y-J Ren, K Liu, X-L Min, L Yang, Y Zhou, J Zheng, C Yang
OBJECTIVE: To investigate the correlations of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) levels with colorectal liver metastasis (CLM) in patients with colorectal cancer (CRC), and determine the effects of transhepatic arterial chemoembolization (TACE) on their expressions. PATIENTS AND METHODS: A total of 110 CRC patients treated in the department of interventional radiology of our hospital from May 2013 to May 2016 were randomly enrolled...
June 2018: European Review for Medical and Pharmacological Sciences
Q-G Tian, Y-T Wu, Y Liu, J Zhang, Z-Q Song, W-F Gao, T-K Guo, C-H He, F-R Dai
OBJECTIVE: To investigate the expressions of HIF-1α, surviving, and VEGF in patients with hepatocarcinoma as well as the correlation analysis among them. PATIENTS AND METHODS: 65 patients, who were admitted to our hospital and diagnosed as hepatocarcinoma from January 2014 to October 2015, were selected as hepatocarcinoma group, while 50 healthy cases that do not have hepatocarcinoma were selected as normal control group. The expression levels of HIF-1α, surviving, and VEGF in hepatocarcinoma tissues of hepatocarcinoma group and normal liver tissues of control group were detected by immunohistochemical (SP) staining method; then, the correlation among them was explored...
June 2018: European Review for Medical and Pharmacological Sciences
M-G Lin, Y-K Hong, Y Zhang, B-B Lin, X-J He
OBJECTIVE: To evaluate the lncRNA DUXAP8 expression in bladder cancer and its mechanism. PATIENTS AND METHODS: Clinical specimens were analyzed. The expression of lncRNA in bladder cancer and adjacent tissues was detected using qRT-PCR. The χ2-test analysis was used to analyze the relationship between lncRNA DUXAP8 expression and clinicopathological information in patients with bladder cancer. The tumor cell activity and cell proliferation were measured by cell counting kit-8 (CCK8) and colony formation assay...
June 2018: European Review for Medical and Pharmacological Sciences
H-H Zhang, A-H Li
OBJECTIVE: Long noncoding RNA FEZF1-AS1 (FEZF1-AS1) has been showed to involve in a variety of cancers. However, its function and clinical significance in cervical cancer (CC) have not been investigated. The aim of this study was to explore the prognostic value of FEZF1-AS1 in CC patients. PATIENTS AND METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the expression level of FEZF1-AS1 in CC specimens and adjacent normal cervical tissues...
June 2018: European Review for Medical and Pharmacological Sciences
Y-S Liu, X-B Liu, Y-Y Qiu, T Lan, Y Chen
OBJECTIVE: Pathogenic mechanism of multiple myeloma is still unclear yet. Abnormality in cell autophagy is closely correlated with various orthopedic diseases especially multiple myeloma. Therefore, this study investigated the mechanism of cell autophagy abnormality in multiple myeloma occurrence and clinical implications. MATERIALS AND METHODS: Using multiple myeloma cell line H929 as the model, cells were treated with UV irradiation. Western blot was used to measure the autophagy of H929 cell, expression level of autophagy molecules and activation of autophagy signal pathway such as Wnt...
June 2018: European Review for Medical and Pharmacological Sciences
Jon Ahlberg, Karin Pukk-Härenstam
In June 2008, WHO launched the Safe Surgery Checklist. Nine months later a Swedish translation and adaptation was launched and distributed to virtually all Swedish hospitals. It gained rapid acceptance; in the fall of 2009, 73 hospitals reported that the checklist had been implemented and that its use was part of standard routine. A questionnaire in 2010 revealed that this was true for many but not all hospitals. International studies have shown that proper use of the checklist has positive effects on postoperative morbidity and mortality...
June 19, 2018: Läkartidningen
Chizu Mimura, Ian J Norman
Purpose: To examine whether attachment styles of healthcare workers influence the quality of their relationships with patients, or impact patients' health outcomes. Data source: Literature database searches on the CINAHL, Cochrane Library, Embase, MEDLINE and PsyCinfo, and hand searching of reference lists of the retained articles. Study selection: Original empirical studies reporting an analysis of the relationship of interest were selected for review...
June 1, 2018: International Journal for Quality in Health Care
Benjamin Leroy-Freschini, Giorgio Treglia, Xavier Argemi, Caroline Bund, Romain Kessler, Raoul Herbrecht, Alessio Imperiale
Background: Opportunistic invasive fungal infections (IFIs) comprise a heterogeneous spectrum of pathogens, whose early diagnosis remains challenging. Candida spp. and Aspergillus spp, the most frequent pathogens in immunocompromised patients, frequently affect lungs, liver, bone and skin. Aim: To evaluate the impact of 18F-FDG PET/CT in the management of immunocompromised patients with IFI. Design: A single-center retrospective study included 51 immunocompromised patients with IFI diagnosis undergoing 83 18F-FDG PET/CTs...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
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