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https://www.readbyqxmd.com/read/29656613/sirna-modified-with-2-deoxy-2-c-methylpyrimidine-nucleosides
#1
Maria Dellafiore, Anna Aviñó, Adele Alagia, Javier M Montserrat, Adolfo Marcelo Iribarren, Ramón Eritja
(2'S)-2'-Deoxy-2'-C-methyluridine and (2'R)-2'-deoxy-2'-C-methyluridine were incorporated in the 3'-overhang region of the sense and antisense strands and in positions 2- and 5- of the seed region of siRNA duplexes directed against Renilla luciferase, while (2'S)-2'-deoxy-2'-C-methylcytidine was incorporated in the 6- position of the seed region of the same constructions. Dual luciferase reporter assay in transfected HeLa cells was used as model system to measure IC50 values of 24 different modified duplexes...
April 14, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29656587/juvenile-hormone-mediates-the-positive-effects-of-nitrogen-fertilization-on-weight-and-reproduction-in-pea-aphid
#2
Jing Gao, Huijuan Guo, Yucheng Sun, Feng Ge
BACKGROUND: The positive effects of nitrogen fertilization on the performance of phytophagous insects have been extensively reported, the physiological and molecular basis involved, however, are largely unclear. Here, we experimentally test whether the enhancement of juvenile hormone (JH) is responsible for the increased weight and fecundity of pea aphid (Acyrthosiphon pisum) under nitrogen fertilization. RESULTS: Aphids fed on Medicago truncatula with nitrogen fertilization have more amino acids content, greater weight at the 4th instar and adult stage, and produce more offspring than those without nitrogen fertilization...
April 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29656584/improving-lymph-node-characterization-in-staging-malignant-lymphoma-using-first-order-adc-texture-analysis-from-whole-body-diffusion-weighted-mri
#3
Katja N De Paepe, Frederik De Keyzer, Pascal Wolter, Oliver Bechter, Daan Dierickx, Ann Janssens, Gregor Verhoef, Raymond Oyen, Vincent Vandecaveye
BACKGROUND: Correct staging and treatment initiation in malignant lymphoma depends on accurate lymph node characterization. However, nodal assessment based on conventional and diffusion-weighted (DWI) MRI remains challenging, particularly in smaller nodes. PURPOSE: To evaluate first-order apparent diffusion coefficient (ADC) texture parameters compared to mean ADC for lymph node characterization in non-Hodgkin lymphoma (NHL) using whole-body DWI (WB-DWI). STUDY TYPE: Retrospective...
April 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29656571/daily-snacking-occasions-and-weight-status-among-us-children-aged-1-to-5-years
#4
Alexandria Kachurak, Adam Davey, Regan L Bailey, Jennifer O Fisher
OBJECTIVE: To characterize associations of snacking frequency with weight status among US children aged 1 to 5 years. METHODS: Participants were children (n = 4,669) aged 1 to 5 years in the 2005 to 2014 National Health and Nutrition Examination Survey (NHANES). Snacking was assessed by two 24-hour dietary recalls using definitions that considered "snack" occasions as well as other foods/beverages consumed between meals. Overweight/obesity (OW/OB) was defined using percentile cutoffs: ≥ 97...
April 14, 2018: Obesity
https://www.readbyqxmd.com/read/29656569/ghanaian-parents-perceptions-of-pre-and-postnatal-nutrient-supplements-and-their-effects
#5
Katherine P Adams, Harriet Okronipa, Seth Adu-Afarwuah, Mary Arimond, Sika Kumordzie, Brietta M Oaks, Maku E Ocansey, Rebecca R Young, Stephen A Vosti, Kathryn G Dewey
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been studied in efficacy and effectiveness trials, but little is known about how parents perceive the products and their effects. In a randomised trial in Ghana, efficacy of SQ-LNS provided to women during pregnancy and the first 6 months postpartum and to their children from 6 to 18 months of age was assessed by comparison with iron-folic acid (IFA) capsules and multiple micronutrient (MMN) capsules provided to women. In a follow-up study conducted when the index children from the original trial were between 4 and 6 years of age, we used survey-based methods to assess retrospective and current parental perceptions of nutrient supplements generally and of SQ-LNS and their effects compared with perceptions IFA and MMN capsules...
April 15, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29656566/absence-of-human-skin-irritation-and-allergenic-potential-after-repeated-patch-applications-of-a-lamellar-moisturizer
#6
Stephanie J Nisbet
BACKGROUND: New cosmetic products should undergo clinical evaluation for skin sensitization potential. OBJECTIVES: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology. METHODS: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV...
April 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29656554/a-single-day-of-bed-rest-irrespective-of-energy-balance-does-not-affect-skeletal-muscle-gene-expression-or-insulin-sensitivity
#7
Marlou L Dirks, Francis B Stephens, Sarah R Jackman, Jesús Galera Gordo, David Machin, Richard M Pulsford, Luc Jc van Loon, Benjamin T Wall
NEW FINDINGS: What is the central question of this study? What are the initial metabolic and molecular events that underpin bed rest-induced skeletal muscle deconditioning, and what is the contribution of energy balance? What is the main finding and its importance? A single day of bed rest, irrespective of energy balance, did not lead to overt changes in skeletal muscle gene expression or insulin sensitivity. More than one day of physical inactivity is required to observe the insulin resistance and robust skeletal muscle transcriptional responses associated with bed rest and consequent alterations in energy balance...
April 15, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29656549/sodium-nitroprusside-is-effective-in-preventing-and-or-reversing-the-development-of-schizophrenia-related-behaviors-in-an-animal-model-the-shr-strain
#8
Mariana C Diana, Fernanda F Peres, Veronica Justi, Rodrigo A Bressan, Acioly L T Lacerda, José Alexandre Crippa, Jaime E C Hallak, Vanesssa Costhek Abilio
AIMS: The treatment of schizophrenia with antipsychotics is still unsatisfactory. Therefore, the search for new treatments and prevention is crucial, and animal models are fundamental tools for this objective. Preclinical and clinical data evidence the antipsychotic profile of sodium nitroprusside (SNP), a nitric oxide (NO) donor. We aimed to investigate SNP in treating and/or preventing the schizophrenia-related behaviors presented by the spontaneously hypertensive rats (SHR) strain...
April 14, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656529/residue-transfer-and-risk-assessment-of-carbendazim-in-tea
#9
Li Zhou, Yaping Jiang, Qin Lin, Xuan Wang, Xinzhong Zhang, Jie Xu, Zongmao Chen
BACKGROUND: The carbendazim residue in tea was a public concern. The large gap in the maximum residue limits (MRLs) for carbendazim in tea made it difficult to conduct pesticide management. Therefore, a systemic evaluation of the residue and health risk of carbendazim from the tea garden to the brewed tea was investigated. RESULTS: The dissipation of carbendazim in tea shoots followed first-order rate kinetics, with a half-life (T1/2 ) of 2.6 days. In green tea manufacturing, the carbendazim decrease of 2...
April 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29656518/genotype-specific-progression-of-hereditary-medullary-thyroid-cancer
#10
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
Although already 25 years into the genomic era, age-related progression of hereditary medullary thyroid cancer (MTC), the prevalence of which is estimated at 1 in 80,000 inhabitants, remains to be delineated for most unique RET (REarranged during Transfection) mutations. Included in this study were 567 RET carriers. The age-related progression of MTC across histopathological groups (normal thyroid/C-cell hyperplasia; node-negative MTC; node-positive MTC) was statistically significant for 13 unique RET mutations (p...
April 14, 2018: Human Mutation
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#11
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29656498/helicobacter-pylori-infection-induced-h3ser10-phosphorylation-in-stepwise-gastric-carcinogenesis-and-its-clinical-implications
#12
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
April 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/29656490/cross-cultural-adaptation-reliability-and-validity-of-the-spanish-version-of-the-neonatal-skin-risk-assessment-scale
#13
Pablo García-Molina, Evelin Balaguer López, José Verdú, Andreu Nolasco, Francisco P García Fernández
AIM: To adapt the Neonatal Skin Risk Assessment Scale to the Spanish context and to test its validity and reliability. BACKGROUND: Currently, in Spain there are no validated scales to evaluate the risk of pressure ulcers in infants. METHOD: The research was performed in 10 neonatal units. Overall, we use an observational study design, but divided it in to three stages. In the first stage, the transcultural adaptation of the scale and its content validation was performed...
April 14, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29656464/design-and-synthesis-of-novel-annulated-thienopyrimidines-as-phosphodiesterase-5-pde5-inhibitors
#14
Lina Y El-Sharkawy, Rowaida A El-Sakhawy, Mohammad Abdel-Halim, Kevin Lee, Gary A Piazza, Christian Ducho, Rolf W Hartmann, Ashraf H Abadi
Novel cycloalkene-fused thienopyrimidine analogues with enhanced phosphodiesterase 5 (PDE5) inhibitory properties are presented. The structure of the reported scaffold was modulated through variation of the terminal cycloalkene ring size, as well as by varying the substituents at position 4 through the attachment of different groups including aniline, benzylamine, cyclohexylethylamine, methyl/acetyl/aryl piperazines, and aryl hydrazones. Compound 15Y with a benzylamine substituent and cycloheptene as terminal ring showed the highest PDE5 inhibitory activity with an IC50 value as low as 190 nM and with good selectivity versus PDE7 and PDE9...
April 14, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29656438/renovascular-hypertension-associated-with-jak2-v617f-positive-myeloproliferative-neoplasms-treated-with-angioplasty-2-cases-and-literature-review
#15
Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito
Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved...
April 14, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29656435/a-multi-omic-study-reveals-btg2-as-a-reliable-prognostic-marker-for-early-stage-non-small-cell-lung-cancer
#16
Sipeng Shen, Ruyang Zhang, Yichen Guo, Elizabeth Loehrer, Yongyue Wei, Ying Zhu, Qianyu Yuan, Sebastian Moran, Thomas Fleischer, Maria Moksnes Bjaanaes, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Li Su, Feng Chen, David C Christiani
B-cell translocation gene 2 (BTG2) is a tumor suppressor protein and is known to be downregulated in several types of cancer. In this study, we investigated a potential role for BTG2 in early-stage non-small cell lung cancer (NSCLC) survival. We analysed BTG2 methylation data from 1,230 early-stage NSCLC patients from five international cohorts, as well as gene expression data from 3,038 lung cancer cases from multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumor tissues were associated with lower overall survival...
April 15, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29656427/exercise-training-abrogates-age-dependent-loss-of-hypothalamic-oxytocinergic-circuitry-and-maintains-high-parasympathetic-activity
#17
Carla R Santos, Adriana Ruggeri, Alexandre Ceroni, Lisete C Michelini
Neuroanatomical studies associating neuronal tract tracing and immunohistochemistry identified reciprocal (ascending noradrenergic/descending oxytocinergic, OTergic) connections between brainstem cardiovascular nuclei and the paraventricular hypothalamic nucleus (PVN). Previous functional studies indicated that exercise training (T) augmented the expression/activity of OTergic pathway and improve the autonomic control of the heart. Knowing that ageing is associated with autonomic dysfunction and sinoaortic denervation blocked T-induced beneficial effects, we hypothesized that T was able to reduce age-dependent impairment by improving the afferent signaling to PVN and augmenting OTergic modulation of cardiovascular control...
April 14, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29656425/atypical-aluminium-patch-tests-in-children-with-persistent-itching-postvaccinal-nodules
#18
Nadia Raison-Peyron, Nathalie Genillier-Foin, Didier Bessis, Brigitte Milpied
Persistent itching nodules related to aluminium-adsorbed vaccines are well known in children with frequent positive patch tests to aluminium when tested. We report two cases of children with persistent postvaccination nodules who presented with atypical eruptions after aluminium patch tests.
April 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29656416/women-infected-with-hiv-and-the-impact-of-associated-sexually-transmitted-infections
#19
REVIEW
Somaia Reda, Fernanda Aguiar Gonçalves, Melissa Mello Mazepa, Newton Sérgio de Carvalho
OBJECTIVE: To review the relationship between concomitant sexually transmitted infections in women infected with HIV. METHODS: PubMed and Scopus were searched for articles published in English and Portuguese between January 1, 1994, and December 31, 2015, using relevant keywords, including AIDS, HIV, female genital diseases, and sexually transmitted infections. Articles that associated sexually transmitted infections with HIV-infected women were selected for inclusion...
April 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29656402/coordination-complexes-of-titanium-iv-and-indium-iii-phthalocyanines-with-carbonyl-containing-dyes-the-formation-of-singly-bonded-anionic-squarylium-dimers
#20
Dmitri Konarev, Alexey Kuzmin, Salavat Khasanov, Aleksey Fatalov, Evgenia Yudanova, Rimma Lyubovskaya
Reduction methods for preparation of coordination complexes of titanium(II) and indium(III) phthalocyanines with organic dyes such as indigo, thioindigo and squarylium dye III (SQ) have been developed which allow one to obtain crystalline {cryptand(K+)}{(cis-indigo-O,O)(0)Ti(II)[Pc(2-)}(Cl-).C6H4Cl2 (1), {cryptand(K+)}{(cis-thioindigo-O, O)(2-)In(III)[Pc(2-)]}(-).C6H4Cl2 (2) and {cryptand(K+)}{[(SQ)2-O, O](2-)In(III)[Pc(2-)]}(-).3.5C6H4Cl2 (3) complexes. The formation of these complexes is accompanied by the reduction of starting dyes or metal phthalocyanines...
April 14, 2018: Chemistry: a European Journal
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