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miR 155

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https://www.readbyqxmd.com/read/29451908/cas9-mediated-excision-of-proximal-dnasei-h3k4me3-signatures-confers-robust-silencing-of-microrna-and-long-non-coding-rna-genes
#1
Harshavardhan Janga, Marina Aznaourova, Fabian Boldt, Katrin Damm, Arnold Grünweller, Leon N Schulte
CRISPR/Cas9-based approaches have greatly facilitated targeted genomic deletions. Contrary to coding genes however, which can be functionally knocked out by frame-shift mutagenesis, non-coding RNA (ncRNA) gene knockouts have remained challenging. Here we present a universal ncRNA knockout approach guided by epigenetic hallmarks, which enables robust gene silencing even in provisionally annotated gene loci. We build on previous work reporting the presence of overlapping histone H3 lysine 4 tri-methylation (H3K4me3) and DNaseI hypersensitivity sites around the transcriptional start sites of most genes...
2018: PloS One
https://www.readbyqxmd.com/read/29442258/evaluation-of-the-effects-of-mirnas-in-familial-mediterranean-fever
#2
Hacer Orsdemir Hortu, Emin Karaca, Betul Sozeri, Nesrin Gulez, Balahan Makay, Cumhur Gunduz, Tahir Atik, Ismihan Merve Tekin, Sevket Erbil Unsal, Cogulu Ozgur
Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. We included 51 patients with genetically diagnosed FMF who had clinical symptoms and 49 healthy volunteers. Fifteen miRNAs that were found to be associated with autoinflammatory diseases and have a part in immune response were evaluated...
February 13, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29441735/the-role-of-mmu-mir-155-5p-nf-%C3%AE%C2%BAb-signaling-in-the-education-of-bone-marrow-derived-mesenchymal-stem-cells-by-gastric-cancer-cells
#3
Mei Wang, Fang Yang, Rong Qiu, Mengchu Zhu, Huiling Zhang, Wenrong Xu, Bo Shen, Wei Zhu
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are important precursors of tumor stromal cells. Previously, we have demonstrated that miR-155-5p inhibition directly induced transition of BM-MSCs into gastric cancer-associated MSCs. Whether miR-155-5p is involved in the education of BM-MSCs by gastric cancer cells has not been established. Murine BM-MSCs (mMSCs) were isolated and grown in conditioned medium derived from gastric cancer cell line MFC (MFC-CM). The tumor-promoting phenotype and function of mMSCs were detected by immunofluorescence staining, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), cell colony formation assay, transwell migration, and invasion assays...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29440644/ultrasensitive-optical-biosensor-for-detection-of-mirna-155-using-positively-charged-au-nanoparticles
#4
Fatemeh Hakimian, Hedayatollah Ghourchian, Azam Sadat Hashemi, Mohammad Reza Arastoo, Mohammad Behnam Rad
An ultrasensitive optical biosensor for microRNA-155 (miR-155) was developed to diagnose breast cancer at early stages. At first, the probe DNA covalently bind to the negatively charged gold nanoparticles (citrate-capped AuNPs). Then, the target miR-155 electrostatically adsorb onto the positively charged gold nanoparticles (polyethylenimine-capped AuNP) surface. Finally, by mixing citrate-capped AuNP/probe and polyethylenimine-capped AuNP/miR-155, hybridization occurs and the optical signal of the mixture give a measure to quantify the miR-155 content...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440068/molecular-characterization-of-renal-cell-carcinoma-a-potential-three-microrna-prognostic-signature
#5
Soum D Lokeshwar, Asif Talukder, Travis J Yates, Martin J P Hennig, Michael Garcia-Roig, Sarrah S Lahorewala, Naureen N Mullani, Zachary Klaassen, Bruce R Kava, Murugesan Manoharan, Mark S Soloway, Vinata Lokeshwar
BACKGROUND: Aberrantly expressed microRNAs (miR) promote renal cell carcinoma (RCC) growth and metastasis and are potentially useful biomarkers for metastatic disease. However, a consensus clinically significant miRNA signature has not been identified. To identify a miRNA signature for predicting clinical outcome in RCC patients we used a four-pronged interconnected approach. METHODS: Differentially expressed miRs were identified and analyzed in 113 specimens (Normal kidney: 59; tumor: 54)...
February 12, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29437031/underexpression-of-mir-486-5p-but-not-overexpression-of-mir-155-is-associated-with-lung-cancer-stages
#6
Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
https://www.readbyqxmd.com/read/29423045/ovatodiolide-targets-chronic-myeloid-leukemia-stem-cells-by-epigenetically-upregulating-hsa-mir-155-suppressing-the-bcr-abl-fusion-gene-and-dysregulating-the-pi3k-akt-mtor-pathway
#7
Yue-Xing Tu, Shi-Bing Wang, Luo-Qin Fu, Shuang-Shuang Li, Qian-Peng Guo, Yi Wu, Xiao-Zhou Mou, Xiang-Min Tong
Chronic myeloid leukemia (CML) is a myeloproliferative pathology, originating from the hematopoietic cancer stem cells (hCSCs) due to the Bcl-Abl Philadelphia chromosome transformation. However, targeting these hCSCs as an effective anti-CML strategy is relatively less explored. Ovatodiolide (Ova) is a natural diterpenoid isolate of Anisomeles indica with broad anticancer activity. In this study, we investigated the anti-hCSCs potential of Ova against CD34+/CD38-, CD34+/CD38+, and unsorted K562 cell lines using flow cytometry, western blot, RT-PCR, genomic mapping, and tumorsphere formation assays...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29420849/expression-of-microrna-155-in-inflammatory-cells-modulates-liver-injury
#8
Delia Blaya, Beatriz Aguilar-Bravo, Fengjie Hao, Silvia Casacuberta-Serra, Mar Coll, Luis Perea, Júlia Vallverdú, Isabel Graupera, Elisa Pose, Laura Llovet, Jordi Barquinero, Francisco Javier Cubero, Juan Caballería, Pere Ginès, Pau Sancho-Bru
miR-155 is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR-155 regulation of liver injury are largely unknown. The role of miR-155 in acute liver injury was assessed in wild type (WT), miR-155-/- and miR-155-/- mice transplanted with WT bone marrow. Additionally, miR-155 expression was evaluated in liver tissue and peripheral blood mononuclear cells (PBMC) of patients with autoimmune hepatitis. Concanavalin A (ConA) but not acetaminophen (APAP) treatment increased the expression of miR-155 in liver tissue of WT mice...
February 8, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29412697/mir-155-affects-osteosarcoma-mg-63-cell-autophagy-induced-by-adriamycin-through-regulating-pten-pi3k-akt-mtor-signaling-pathway
#9
Lin Wang, Bing Tang, Heng Han, Dan Mao, Jie Chen, Yun Zeng, Min Xiong
OBJECTIVE: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a positive regulatory role on cell autophagy through inhibiting PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway. miR-155 plays a critical role in osteosarcoma occurrence and chemoresistance. Bioinformatics analysis revealed the targeted binding site between miR-155 and the 3'-UTR (untranslated region) of PTEN mRNA. This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway...
February 7, 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29411649/alteration-in-microrna-155-level-correspond-to-severity-of-coronary-heart-disease
#10
Xian-Ke Qiu, Jun Ma
Cardiovascular diseases are a consequence of genetic and epigenetic interactions. Inflammation contributes toward the initiation and progression of atherosclerotic lesions. Previous studies have shown that microRNA (miR) 155 plays a role in cardiovascular disease, including the prevention of inflammatory infiltration, regulation of autophagy, and participation of immunoreactions. However, the change of miR-155 level in the development of atherosclerosis remains to be determined. The initial objective of this study was that CHD patients would have altered serum miR-155 level...
February 7, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29410668/sulforaphane-inhibits-lipopolysaccharide-induced-inflammation-cytotoxicity-oxidative-stress-and-mir-155-expression-and-switches-to-mox-phenotype-through-activating-extracellular-signal-regulated-kinase-1-2-nuclear-factor-erythroid-2-related-factor-2-antioxidant
#11
Erden Eren, Kemal Ugur Tufekci, Kamer Burak Isci, Bora Tastan, Kursad Genc, Sermin Genc
Sulforaphane (SFN) is a natural product with cytoprotective, anti-inflammatory, and antioxidant effects. In this study, we evaluated the mechanisms of its effects on lipopolysaccharide (LPS)-induced cell death, inflammation, oxidative stress, and polarization in murine microglia. We found that SFN protects N9 microglial cells upon LPS-induced cell death and suppresses LPS-induced levels of secreted pro-inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6. SFN is also a potent inducer of redox sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), which is responsible for the transcription of antioxidant, cytoprotective, and anti-inflammatory genes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29409452/whole-blood-micrornas-as-potential-biomarkers-in-post-operative-early-breast-cancer-patients
#12
Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K Trapp, Marie Tzschaschel, Sven Mahner, Peter A Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W P Friedl, Wolfgang Janni, Brigitte Rack
BACKGROUND: microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patients (EBC) to assess the utility of miRNAs as prognostic markers in this setting. METHOD: A total of 48 post-operative patients, recruited in frame of the SUCCESS A trial, were included in this retrospective study and tested with a panel of 8 miRNAs (miR-10b, -19a, - 21, - 22, -20a, - 127, - 155, -200b)...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29404871/involvement-of-the-negative-feedback-of-il-33-signaling-in-the-anti-inflammatory-effect-of-electro-acupuncture-on-allergic-contact-dermatitis-via-targeting-microrna-155-in-mast-cells
#13
Zhigang Wang, Tao Yi, Man Long, Fengmin Ding, Lichen Ouyang, Zebin Chen
In this study, we aimed to investigate the effect of electro-acupuncture (EA) at the Zusanli acupoint (ST36) on interleukin (IL)-33-mediated mast cell activation. Firstly, 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats was developed with or without EA treatment. Then, rat peritoneal mast cells (RPMCs) were obtained and cultured in the presence of IL-33. EA treatment relieved ear swelling and reduced mast cell infiltration in the local inflammation area with DNFB challenge, accompanying the decrement of IL-33 production...
February 5, 2018: Inflammation
https://www.readbyqxmd.com/read/29403643/down-syndrome-and-micrornas
#14
Aldina Brás, António S Rodrigues, Bruno Gomes, José Rueff
In recent years numerous studies have indicated the importance of microRNAs (miRNA/miRs) in human pathology. Down syndrome (DS) is the most prevalent survivable chromosomal disorder and is attributed to trisomy 21 and the subsequent alteration of the dosage of genes located on this chromosome. A number of miRNAs are overexpressed in down syndrome, including miR-155, miR-802, miR- 125b-2, let-7c and miR-99a. This overexpression may contribute to the neuropathology, congenital heart defects, leukemia and low rate of solid tumor development observed in patients with DS...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29391047/regulatory-role-of-microrna-in-mesenteric-lymph-nodes-after-salmonella-typhimurium-infection
#15
Juber Herrera-Uribe, Sara Zaldívar-López, Carmen Aguilar, Cristina Luque, Rocío Bautista, Ana Carvajal, M Gonzalo Claros, Juan J Garrido
Salmonellosis is a gastrointestinal disease caused by non-typhoidal Salmonella serovars such as Salmonella Typhimurium. This pathology is a zoonosis, and food animals with subclinical infection constitute a vast reservoir for disease. After intestinal colonization, Salmonella Typhimurium reaches mesenteric lymph nodes (MLN), where infection is controlled avoiding systemic spread. Although the molecular basis of this infection has been extensively studied, little is known about how microRNA (miRNA) regulate the expression of proteins involved in the Salmonella-host interaction...
February 1, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29386283/modified-cross-linking-ligation-and-sequencing-of-hybrids-qclash-identifies-kshv-microrna-targets-in-endothelial-cells
#16
Lauren A Gay, Sunantha Sethuraman, Merin Thomas, Peter C Turner, Rolf Renne
KS tumors are derived from endothelial cells and express KHSV microRNAs (miRNAs). Although miRNA targets have been identified in B cell lymphoma-derived cells and in epithelial cells, little has been done to characterize the KSHV miRNA targetome in endothelial cells. A recent innovation in the identification of miRNA targetomes, Cross-linking, Ligation, and Sequencing of Hybrids (CLASH), unambiguously identifies miRNAs and their targets by ligating the two species while both are still bound within the RNA-Induced Silencing Complex (RISC)...
January 31, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29385860/serum-mirnas-in-women-affected-by-hyperandrogenic-polycystic-ovary-syndrome-the-potential-role-of-mir-155-as-a-biomarker-for-monitoring-the-estroprogestinic-treatment
#17
Walter Arancio, Marco Calogero Amato, Miriam Magliozzo, Giuseppe Pizzolanti, Rosalia Vesco, Carla Giordano
MicroRNAs can be used as very efficient circulating biomarkers. The role of microRNAs in polycystic ovary syndrome (PCOS) and the effects of antiandrogen therapy on microRNA expression is still not fully understood. A panel of serum microRNAs were retrotranscribed via looped reverse primer transcription specific for each miRNA and quantified via probe specific RT-PCR in 16 Caucasian hyperandrogenic PCOS women selected according to the Rotterdam criteria and in a subset of seven patients after four months of sequential reverse antiandrogenic therapy...
January 31, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29378472/discriminatory-mirnas-for-the-management-of-papillary-thyroid-carcinoma-and-noninvasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features
#18
Iman Jahanbani, Abeer Al-Abdallah, Rola Ali, Nabeel Al-Brahim, Olusegun Mojiminiyi
BACKGROUND: Papillary thyroid carcinoma (PTC) variants have several overlapping clinical and pathological features. The World Health Organization (WHO) published recently a new classification of thyroid tumors containing significant revisions. the encapsulated papillary thyroid carcinoma (EPTC) has been recognized as a distinctive variant of PTC. The noninvasive encapsulated follicular variant of PTC has been reclassified as "Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP)"...
January 29, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29371906/profile-of-epigenetic-mechanisms-in-lung-tumors-of-patients-with-underlying-chronic-respiratory-conditions
#19
Mercè Mateu-Jimenez, Víctor Curull, Alberto Rodríguez-Fuster, Rafael Aguiló, Albert Sánchez-Font, Lara Pijuan, Joaquim Gea, Esther Barreiro
Background: Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and epigenetic events underlie lung cancer (LC) development. The study objective was that lung tumor expression levels of specific microRNAs and their downstream biomarkers may be differentially regulated in patients with and without COPD. Methods: In lung specimens (tumor and non-tumor), microRNAs known to be involved in lung tumorigenesis (miR-21, miR-200b, miR-126, miR-451, miR-210, miR-let7c, miR-30a-30p, miR-155 and miR-let7a, qRT-PCR), DNA methylation, and downstream biomarkers were determined (qRT-PCR and immunoblotting) in 40 patients with LC (prospective study, subdivided into LC-COPD and LC, N = 20/group)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29366836/prognostic-value-of-microrna-155-in-human-carcinomas-an-updated-meta-analysis
#20
REVIEW
Kangkang Liu, Kun Zhao, Lining Wang, Erlin Sun
BACKGROUND: miR-155 functions as an oncomiR or as an oncosuppressor-miR in human cancer. Although miR-155 has been researched in many cancers, its prognostic value is uncertain. METHODS: We performed a literature search in up-to-date electronic databases including PubMed and Embase to obtain as many relevant articles as possible. Combined hazard ratios (HR) of miR-155 for outcome were analyzed. RESULTS: A total of 24 papers researching different cancers were included in this meta-analysis...
January 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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