keyword
https://read.qxmd.com/read/38531978/homocysteine-metabolites-inhibit-autophagy-by-upregulating-mir-21-5p-mir-155-5p-mir-216-5p-and-mir-320c-3p-in-human-vascular-endothelial-cells
#1
JOURNAL ARTICLE
Łukasz Witucki, Hieronim Jakubowski
Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired autophagy causes the accumulation of damaged proteins and organelles and is associated with CVD. Biochemically, HHcy is characterized by elevated levels of Hcy and its metabolites, Hcy-thiolactone and N-Hcy-protein. However, whether these metabolites can dysregulate mTOR signaling and autophagy in endothelial cells is not known...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38528688/soy-derived-isoflavones-as-chemo-preventive-agents-targeting-multiple-signalling-pathways-for-cancer-prevention-and-therapy
#2
REVIEW
Agnieszka Kaufman-Szymczyk, Justyna Jalmuzna, Katarzyna Lubecka-Gajewska
The chemopreventive and chemotherapeutic properties of soy and soy-derived compounds, especially isoflavones, have been extensively studied in recent years. However, in contrast to their anticancer effects, such as cell growth inhibition, cell cycle arrest and apoptosis induction, isoflavones have also been found to promote the growth of cancer cells. Therefore, the aim of this comprehensive review article is to present the current state of knowledge regarding the molecular mechanisms by which soy-derived isoflavones target multiple cellular signalling pathways in cancer cells...
March 25, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38520867/the-role-of-mir-155-in-urologic-malignancies
#3
REVIEW
Maolei Shen, Tao Chen, Xin Li, Shankun Zhao, Xinsheng Zhang, Liying Zheng, Biao Qian
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in regulating gene expression across multiple levels. They are involved in a wide range of physiological processes, including proliferation, differentiation, apoptosis, and cell cycle control. In recent years, miRNAs have emerged as pivotal regulatory molecules in the development and progression of tumors. Among these, miR-155 has garnered significant attention due to its high expression in various diseases, particularly urologic malignancies...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38517783/expression-level-of-non-coding-mir-155-gene-as-biomarker-for-severity-of-coronaviruses-infection-among-vaccinated-and-non-vaccinated-iraqi-patients
#4
JOURNAL ARTICLE
Halah Kadhim, Abdulameer Ghareeb, Mohammed Alhilal
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 is influenced by genetic and epigenetic factors, including miR-155, which affects immune cell and virus functions and laboratory biomarkers. OBJECTIVE: T0 evaluates miR-155's role as a biomarker for SARS-CoV-2 detection and monitoring, examining its significance in identifying infection in both vaccinated and unvaccinated individuals using ROC curve analysis. METHODS: Blood samples were collected from 70 patients who attended Medical City Hospital in Baghdad from June 2022 to April 2023 and were determined to be associated with SARS-CoV-2 (35 patients were hospitalized at the Intensive Care Units due to the severity of their symptoms while the other 35 were left hospital upon treatment...
March 6, 2024: Human Antibodies
https://read.qxmd.com/read/38508350/the-piezo1-mir-155-5p-gdf6-smad2-3-signaling-axis-is-involved-in-inducing-the-occurrence-and-progression-of-osteoarthritis-under-excessive-mechanical-stress
#5
JOURNAL ARTICLE
Chaoren Qin, Yan Feng, Zhaowei Yin, Changjiang Wang, Rui Yin, Yang Li, Kai Chen, Tianqi Tao, Kaibin Zhang, Yiqiu Jiang, Jianchao Gui
OBJECTIVE: To elucidate the molecular mechanism of overloading-induced osteoarthritis (OA) and to find a novel therapeutic target. METHODS: We utilized human cartilage specimens, mouse chondrocytes, a destabilization of the medial meniscus (DMM) mouse model, and a mouse hindlimb weight-bearing model to validate the role of overloading on chondrocyte senescence and OA development. Then, we observed the effect of PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling axis on the preservation of joint metabolic homeostasis under overloading in vivo, in vitro and ex vivo by qPCR, Western blot, enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, immunofluorescence, SA-β-gal staining, CCK8 assay, et al...
March 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38504278/correction-microrna-155-mir-155-as-an-accurate-biomarker-of-periodontal-status-and-coronary-heart-disease-severity-a-case-control-study
#6
Zina A Daily, Batool Hassan Al-Ghurabi, Ahmed Makki A Al-Qarakhli, Ryan Moseley
No abstract text is available yet for this article.
March 19, 2024: BMC Oral Health
https://read.qxmd.com/read/38497832/tantalum-particles-promote-m2-macrophage-polarization-and-regulate-local-bone-metabolism-via-macrophage-derived-exosomes-influencing-the-fates-of-bmscs
#7
JOURNAL ARTICLE
Junjun Yang, Xiaoyuan Gong, Tao Li, Zengzilu Xia, Rui He, Xiongbo Song, Xin Wang, Jiangyi Wu, Jiajia Chen, Fangzheng Wang, Ran Xiong, Yangjing Lin, Guangxing Chen, Liu Yang, Kaiyong Cai
In this study, we explored the regulatory role and mechanisms of tantalum (Ta) particles in the bone tissue microenvironment. Ta particle deposition occurs in both clinical samples and animal tissues following porous Ta implantation. Unlike titanium (Ti) particles promoting M1 macrophage (Mϕ) polarization, Ta particles regulating calcium signaling pathways and promoting M2 Mϕ polarization. Ta-induced M2 Mϕ enhance bone marrow-derived mesenchymal stem cells (BMSCs) proliferation, migration, and osteogenic differentiation through exosomes (Exo) by upregulating miR-378a-3p/miR-221-5p and downregulating miR-155-5p/miR-212-5p...
March 18, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38493774/kaempferol-ameliorated-alcoholic-hepatitis-through-improving-intestinal-barrier-function-by-targeting-mirna-155-signaling
#8
JOURNAL ARTICLE
Wenyan Zhong, Jingjing Chen, Guangfu Xu, Li Xiao
INTRODUCTION: To investigate the effect and mechanism of Kaempferol on alcoholic steatohepatitis. METHODS: C57BL/6 N mice were utilized to establish Binge-on-Chronic alcohol exposure mice model. Kaempferol was given as the interventional drug to chronic alcohol-fed mice for six weeks to assess its effects. In vitro, intestinal epithelial Caco-2 cells were stimulated by alcohol, and miRNA-155 mimics were used to further study the effect of kaempferol to miRNA-155 signaling in intestinal epithelial cells...
March 16, 2024: Pharmacology
https://read.qxmd.com/read/38492338/butyrate-alleviates-alcoholic-liver-disease-associated-inflammation-through-macrophage-regulation-and-polarization-via-the-hdac1-mir-155-axis
#9
JOURNAL ARTICLE
Lina Zhang, Zhiguo Ma, Xiaoxu Zhang, Jing Wang, Wenyan Tian, Yi Ren, Yajuan Liu, Ting Wang, Yiwei Li, Yuanyuan Liu, Wenke Shen, Ting Li, Jian Liu, Junbai Ma, Xiaoxia Zhang, Shaoqi Yang, Hao Wang
BACKGROUND: We recently found that butyrate could ameliorate inflammation of alcoholic liver disease (ALD) in mice. However, the exact mechanism remains incompletely comprehended. Here, we examined the role of butyrate on ALD-associated inflammation through macrophage (Mψ) regulation and polarization using in vivo and in vitro experiments. METHODS: For in vivo experiments, C57BL/6J mice were fed modified Lieber-DeCarli liquid diets supplemented with or without ethanol and sodium butyrate (NaB)...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492053/dexamethasone-relieves-the-inflammatory-response-caused-by-inguinal-hernia-meshes-through-mir-155
#10
JOURNAL ARTICLE
Y Li, Y Lv, J Li, P Ling, X Guo, L Zhang, J Ni, Y Long
BACKGROUND: Inguinal hernia is a relatively common condition. Most patients with inguinal hernia require surgery. At present, mesh repair is one of the most effective methods to treat inguinal hernia, but insertion of the mesh can cause inflammation. Dexamethasone (DEX) can treat inflammation, but the mechanism by which DEX alleviates inflammation caused by inguinal hernia mesh placement remains unclear. METHOD: We randomly divided rats into groups: negative control (NC), inguinal hernia (IH), polypropylene mesh (PM), DEX treatment, and miR-155 treatment groups...
March 16, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38489968/a-point-of-care-electrochemical-biosensor-for-the-rapid-and-sensitive-detection-of-biomarkers-in-murine-models-with-lps-induced-sepsis
#11
JOURNAL ARTICLE
Neil Adrian P Ondevilla, Peng-Wen Liu, Wan-Ting Huang, Tzu-Ping Weng, Nan-Yao Lee, Syu-Cing Ma, Jian-Jang Huang, Tak-Wah Wong, Hsien-Chang Chang
Sepsis is a life-threatening condition, which is irreversible if diagnosis and intervention are delayed. The response of the immune cells towards an infection triggers widespread inflammation through the production of cytokines, which may result in multiple organ dysfunction and eventual death. Conventional detection techniques fail to provide a rapid diagnosis because of their limited sensitivity and tedious protocol. This study proposes a point-of-care (POC) electrochemical biosensor that overcomes the limitations of current biosensing technologies in the clinical setting by its integration with electrokinetics, enhancing the sensitivity to picogram level compared with the nanogram limit of current diagnostic technologies...
March 10, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38486224/exosomal-mirnas-expression-and-growth-factors-released-by-mononuclear-cells-of-clad-patients-in-response-to-extracorporeal-photopheresis
#12
JOURNAL ARTICLE
Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Claudia Del Fante, Eugenio Barone, Simona De Vitis, Mara De Amici, Giorgia Testa, Stefania Croce, Chiara Valsecchi, Maria A Avanzini, Rosalia Cacciatore, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, Federica Meloni
BACKGROUND: CLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions of Extracorporeal Photopheresis (ECP)-treated patients improve/stabilize their graft function. In spite of that, data concerning molecular mechanisms are still lacking. Aims of our study were to assess whether ECP effects are mediated by Mononuclear Cells (MNCs) modulation in term of microRNAs (miRNAs) expression and growth factors release...
March 14, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38479317/assessing-the-toxicity-of-pesticides-exposure-on-hepatic-mirna-target-gene-alterations-in-rat-liver-tissues-via-molecular-and-integrated-network-bioinformatics-analysis
#13
JOURNAL ARTICLE
Hakeemah Al-Nakhle, Ahmed El-Tokhy, Heba Eltahir, Mohammed Almuayrifi, Mekky Abouzied, Khaled Abdelaal, Muayad Albadrani
The prevalent use of pesticides, including pirimiphos-methyl (PPM) and bifenthrin (BF), poses a serious health risk, particularly to workers who encounter these chemicals daily. Despite the recognized hepatotoxic effects, the specific molecular mechanisms, especially those involving miRNAs in liver damage caused by PPM and BF, are not fully elucidated. Prior studies have not exhaustively analyzed the hepatic miRNA-target gene dynamics following exposure to these pesticides; thus, this research aims to fill that gap through an extensive miRNA analysis to discern their regulation in PPM or BF-induced hepatic toxicity...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38479158/dapagliflozin-prevents-kidney-podocytes-pyroptosis-via-mir-155-5p-ho-1-nlrp3-axis-modulation
#14
JOURNAL ARTICLE
Zhen-Wang Zhang, Ming-Qiu Tang, Wu Liu, Yi Song, Man-Jun Gao, Ping Ni, Dan-Dan Zhang, Qi-Gui Mo, Bao-Qing Zhao
Diabetic nephropathy (DN) is a significant clinical microvascular complication associated with diabetes mellitus (DM), and end-stage diabetes giving rise to kidney failure is developing into the major etiological factor of chronic kidney failure. Dapagliflozin is reported to limit podocyte damage in DM, which has proven to protect against renal failure. Mounting evidence has demonstrated that pyroptosis is associated with DM progression. Nevertheless, whether pyroptosis causes DN and the underlying molecular pathways remain obscure...
March 12, 2024: International Immunopharmacology
https://read.qxmd.com/read/38476899/role-of-micrornas-in-cognitive-decline-related-to-covid%C3%A2-19-review
#15
REVIEW
Anastasia Bougea, Vasiliki Epameinondas Georgakopoulou, Ioannis G Lempesis, George Fotakopoulos, Petros Papalexis, Pagona Sklapani, Nikolaos Trakas, Demetrios A Spandidos, Efthalia Angelopoulou
The likelihood and severity of cognitive decline related to coronavirus disease 2019 (COVID-19) have been shown to be reflected by the severity of the infection and concomitant alterations in specific biomarkers. The present review discusses the role of microRNAs (miRNAs/miRs) as biomarkers in COVID-19 and the potential molecular mechanisms of cognitive dysfunction related to COVID-19. A systematic search of published articles was carried out from January 31, 2000 to December 31, 2022 using the PubMed, ProQuest, Science Direct and Google Scholar databases, combining the following terms: 'COVID-19' OR 'SARS-CoV-2' OR 'post-COVID-19 effects' OR 'cognitive decline' OR 'neurodegeneration' OR 'microRNAs'...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38473794/the-phytochemical-agathisflavone-modulates-mir146a-and-mir155-in-activated-microglia-involving-stat3-signaling
#16
JOURNAL ARTICLE
Balbino Lino Dos Santos, Cleonice Creusa Dos Santos, Karina Costa da Silva, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Jorge Mauricio David, Juciele Valéria Ribeiro de Oliveira, Maria de Fátima Dias Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silva, Silvia Lima Costa
MicroRNAs (miRs) act as important post-transcriptional regulators of gene expression in glial cells and have been shown to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Here, we investigated the effects of agathisflavone, a biflavonoid purified from the leaves of Cenostigma pyramidale (Tul.), on modulating the expression of miRs and inflammatory mediators in activated microglia. C20 human microglia were exposed to oligomers of the β-amyloid peptide (Aβ, 500 nM) for 4 h or to lipopolysaccharide (LPS, 1 µg/mL) for 24 h and then treated or not with agathisflavone (1 µM) for 24 h...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472734/anexelekto-axl-no-more-microrna-155-mir-155-controls-the-uncontrolled-in-sars-cov-2
#17
REVIEW
K I Papadopoulos, A Papadopoulou, T C Aw
AXL is the gene that encodes the Anexelekto (AXL) receptor tyrosine kinase that demonstrates significant roles in various cellular processes, including cell growth, survival, and migration. Anexelekto is a Greek word meaning excessive and uncontrolled, semantically implying the crucial involvement of AXL in cancer and immune biology, and in promoting cancer metastasis. AXL overexpression appears to drive epithelial to mesenchymal transition, tumor angiogenesis, decreased antitumor immune response, and resistance to therapeutic agents...
March 12, 2024: Human Cell
https://read.qxmd.com/read/38466003/protective-effects-of-aspirin-supplemented-with-quercetin-in-l-name-induced-preeclampsia-like-rats
#18
JOURNAL ARTICLE
J Ding, S Yang, D Chen, X Shi, Y Zhang, L Song, J Zhang
Aspirin supplemented with quercetin was reported to enhance the therapeutic effects of aspirin in a rat model of preeclampsia. In this study, the underlying mechanisms were further explored. Preeclampsia was induced by L-NAME (50 mg/kg/day) via oral gavage from gestation day (GD)14 to GD19. Aspirin (1.5 mg/kg/day) administration was performed using aspirin mixed with rodent dough from GD0 to GD19. The administration of quercetin (2 mg/kg/day) was performed by intraperitoneal infusion from GD0 to GD19. Protein levels were evaluated using ELISA or Western blot, and microRNA (miRNA) level was evaluated by RT-PCR...
March 11, 2024: Physiological Research
https://read.qxmd.com/read/38462731/factors-associated-with-the-maintenance-of-cost-effectiveness-at-5-years-in-adult-spinal-deformity-corrective-surgery
#19
JOURNAL ARTICLE
Peter G Passias, Jamshaid M Mir, Pooja Dave, Justin S Smith, Renaud Lafage, Jeffrey Gum, Breton G Line, Bassel Diebo, Alan H Daniels, David Kojo Hamilton, Thomas J Buell, Justin K Scheer, Robert K Eastlack, Jeffrey P Mullin, Gregory M Mundis, Naobumi Hosogane, Mitsuru Yagi, Andrew J Schoenfeld, Juan S Uribe, Neel Anand, Praveen V Mummaneni, Dean Chou, Eric O Klineberg, Khaled M Kebaish, Stephen J Lewis, Munish C Gupta, Han Jo Kim, Robert A Hart, Lawrence G Lenke, Christopher P Ames, Christopher I Shaffrey, Frank J Schwab, Virginie Lafage, Richard A Hostin, Shay Bess, Douglas C Burton
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To evaluate factors associated with the long-term durability of cost-effectiveness (CE) in ASD patients. BACKGROUND: A substantial increase in costs associated with the surgical treatment for adult spinal deformity (ASD) has given precedence to scrutinize the value and utility it provides. METHODS: We included 327 operative ASD patients with 5-year (5 Y) follow-up. Published methods were used to determine costs based on CMS...
March 11, 2024: Spine
https://read.qxmd.com/read/38452956/decrease-of-exosomal-mir-21-5p-and-the-increase-of-cd62p-exosomes-are-associated-with-the-development-of-sepsis-in-polytraumatized-patients
#20
JOURNAL ARTICLE
Birte Weber, Dirk Henrich, Ingo Marzi, Liudmila Leppik
Sepsis as a severe systemic inflammation leads oftentimes to organ dysfunction and subsequently to death. In polytrauma patients, septic complications represent with 45% the predominant cause of late death and are responsible for extremely high costs in the healthcare system. Therefore, clinicians have to detect as early as possible the begin of sepsis to improve the patient's outcome. One new promising diagnostic tool to diagnose septic complications in polytraumatized patients are exosomes. Plasma samples from polytraumatized patients (Injury Severity Score (ISS) ≥16) which developed sepsis (n = 10) and without sepsis (n = 10), were collected at emergency room (ER), 24h and 5 days after trauma...
March 5, 2024: Molecular and Cellular Probes
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