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https://www.readbyqxmd.com/read/29475104/distress-and-sleep-quality-in-young-amphetamine-type-stimulant-users-with-an-affective-or-psychotic-illness
#1
Jacob J Crouse, Rico S C Lee, Django White, Ahmed A Moustafa, Ian B Hickie, Daniel F Hermens
Misuse of amphetamine-type stimulant (ATS) drugs may disrupt key neurodevelopmental processes in young people and confer protracted neurocognitive and psychopathological harm. ATS users with a co-occurring psychiatric illness are typically excluded from research, reducing generalisability of findings. Accordingly, we conducted a cross-sectional examination of key clinical, sleep, socio-occupational and neurocognitive measures in current, past and never users of ATS drugs who were accessing a youth mental health service (headspace) for affective- or psychotic-spectrum illnesses...
February 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29475103/increased-delayed-reward-during-intertemporal-decision-making-in-schizophrenic-patients-and-their-unaffected-siblings
#2
Lu Wang, Shengchun Jin, Kongliang He, Xingui Chen, Gongjun Ji, Xiaomeng Bai, Guixian Xiao, Huijuan Ma, Kai Wang
Intertemporal choices are decisions with consequences in multiple time periods and constitute a significant part of social cognition. The shared neuropathological characteristics of patients with schizophrenia and their siblings might express intermediate phenotypes in behavior that could be used to further characterize the illness. Schizophrenic patients, unaffected siblings, and healthy controls underwent a computerized version of the "Intertemporal Choice Task". All participants could choose between sooner-smaller (SS) and later-larger (LL) options in now-trials and in not-now-trials...
December 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29475010/impact-of-a-mental-health-based-primary-care-program-on-emergency-department-visits-and-inpatient-stays
#3
Joshua Breslau, Emily Leckman-Westin, Bing Han, Riti Pritam, Diana Guarasi, Marcela Horvitz-Lennon, Deborah M Scharf, Molly T Finnerty, Hao Yu
OBJECTIVE: Integrating primary care services into specialty mental health clinics has been proposed as a method for improving health care utilization for medical conditions by adults with serious mental illness. This paper examines the impact of a mental health based primary care program on emergency department (ED) visits and hospitalizations. METHOD: The program was implemented in seven New York City outpatient mental health clinics in two waves. Medicaid claims were used to identify patients treated in intervention clinics and a control group of patients treated in otherwise similar clinics in New York City...
February 17, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29474938/differential-family-experience-of-palliative-sedation-therapy-in-specialised-palliative-or-critical-care-units
#4
Hui-Shan Shen, Szu-Yin Chen, Denise Shuk Ting Cheung, Shu-Yi Wang, Lee Jung Jae, Chia-Chin Lin
CONTEXT: No study has examined the varying family experience of palliative sedation therapy (PST) for terminally ill patients in different settings. OBJECTIVES: To examine and compare family concerns about PST use and its effect on the grief suffered by terminally ill patients' families in palliative care units (PCU) or intensive care units (ICU). METHODS: A total of 154 family members of such patients were recruited in Taiwan, of whom 143 completed the study, with 81 from the PCU and 62 from the ICU...
February 20, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29474802/exploring-perceptions-about-insulin-dependent-diabetes-mellitus-in-adolescent-patients-and-peers
#5
Katarzyna Marshall, Halley Martin, Kim Siarkowski Amer
Friends can provide encouragement and support during stressful times. Friends are even more important for children coping with chronic illness such as adolescents managing insulin dependent diabetes mellitus (IDDM). Nurses need to recognize that the knowledge and care of both the children coping with diabetes and friends can be critical. This study explored perceptions of adolescents managing diabetes and their peers. The non-affected peers and adolescents with IDDM ranged in age between 15-18 were studied using an exploratory qualitative method...
March 2018: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29474680/shared-genetic-risk-of-schizophrenia-and-gray-matter-reduction-in-6p22-1
#6
Jiayu Chen, Vince D Calhoun, Dongdong Lin, Nora I Perrone-Bizzozero, Juan R Bustillo, Godfrey D Pearlson, Steven G Potkin, Theo G M van Erp, Fabio Macciardi, Stefan Ehrlich, Beng-Choon Ho, Scott R Sponheim, Lei Wang, Julia M Stephen, Andrew R Mayer, Faith M Hanlon, Rex E Jung, Brett A Clementz, Matcheri S Keshavan, Elliot S Gershon, John A Sweeney, Carol A Tamminga, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Jessica A Turner, Jingyu Liu
Genetic factors are known to influence both risk for schizophrenia (SZ) and variation in brain structure. A pressing question is whether the genetic underpinnings of brain phenotype and the disorder overlap. Using multivariate analytic methods and focusing on 1,402 common single-nucleotide polymorphisms (SNPs) mapped from the Psychiatric Genomics Consortium (PGC) 108 regions, in 777 discovery samples, we identified 39 SNPs to be significantly associated with SZ-discriminating gray matter volume (GMV) reduction in inferior parietal and superior temporal regions...
February 21, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29474673/genetic-instability-associated-with-loop-or-stem-loop-structures-within-transcription-units-can-be-independent-of-nucleotide-excision-repair
#7
John A Burns, Moinuddin A Chowdhury, Laura Cartularo, Christian Berens, David A Scicchitano
Simple sequence repeats (SSRs) are found throughout the genome, and under some conditions can change in length over time. Germline and somatic expansions of trinucleotide repeats are associated with a series of severely disabling illnesses, including Huntington's disease. The underlying mechanisms that effect SSR expansions and contractions have been experimentally elusive, but models suggesting a role for DNA repair have been proposed, in particular the involvement of transcription-coupled nucleotide excision repair (TCNER) that removes transcription-blocking DNA damage from the transcribed strand of actively expressed genes...
February 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29474661/models-of-schizotypy-the-importance-of-conceptual-clarity
#8
Phillip Grant, Melissa J Green, Oliver J Mason
The observation of psychosis-like traits that resemble symptoms of schizophrenia and bipolar disorder, both among healthy relatives of psychotic patients and among the general population, can be traced to the early 20th century.1,2 These traits have since been described within various models of illness and health (ie, normal/abnormal personality, abnormal psychotic continua), each giving rise to concepts such as "schizotypy," "psychoticism," and "psychosis-proneness" that are not necessarily interchangeable, although their subtle distinctions are often overlooked...
February 21, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29474394/assessment-of-water-sanitation-and-hygiene-interventions-in-response-to-an-outbreak-of-typhoid-fever-in-neno-district-malawi
#9
Sarah D Bennett, Sara A Lowther, Felix Chingoli, Benson Chilima, Storn Kabuluzi, Tracy L Ayers, Thomas A Warne, Eric Mintz
On May 2, 2009 an outbreak of typhoid fever began in rural villages along the Malawi-Mozambique border resulting in 748 illnesses and 44 deaths by September 2010. Despite numerous interventions, including distribution of WaterGuard (WG) for in-home water treatment and education on its use, cases of typhoid fever continued. To inform response activities during the ongoing Typhoid outbreak information on knowledge, attitudes, and practices surrounding typhoid fever, safe water, and hygiene were necessary to plan future outbreak interventions...
2018: PloS One
https://www.readbyqxmd.com/read/29474350/is-parenteral-hydration-beneficial-in-terminally-ill-cancer-patients
#10
José Canihuante, Pedro Pérez
INTRODUCTION: It is common for terminally ill patients to have a reduced fluid intake, which often results in a need for more medical support. However, it is not clear if this measure has a real clinical impact. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data from primary studies and generated a summary of findings table using the GRADE approach...
February 12, 2018: Medwave
https://www.readbyqxmd.com/read/29474336/endothelial-cell-specific-molecule-1-in-critically-ill-patients-with-hematologic-malignancy
#11
Lara Zafrani, Matthieu Resche-Rigon, Nathalie De Freitas Caires, Alexandre Gaudet, Daniel Mathieu, Erika Parmentier-Decrucq, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine N'yunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
OBJECTIVES: To assess whether serum concentration of endothelial cell-specific molecule-1 (Endocan) at ICU admission is associated with the use of ICU resources and outcomes in critically ill hematology patients. DESIGN: Prospective multicenter cohort study. SETTING: Seventeen ICUs in France and Belgium. PATIENTS: Seven hundred forty-four consecutive critically ill hematology patients; 72 critically ill septic patients without hematologic malignancy; 276 healthy subjects...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474333/severity-of-illness-vis-%C3%A3-vis-neuropsychologic-outcomes-in-critically-ill-neonates
#12
Troy E Dominguez, Suzan Kakat, Jo Wray
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474329/how-critical-illness-affects-the-brain%C3%A2-and-vice-versa
#13
Thomas P Bleck
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474321/evaluation-of-icu-risk-models-adapted-for-use-as-continuous-markers-of-severity-of-illness-throughout-the-icu-stay
#14
Omar Badawi, Xinggang Liu, Erkan Hassan, Pamela J Amelung, Sunil Swami
OBJECTIVES: Evaluate the accuracy of different ICU risk models repurposed as continuous markers of severity of illness. DESIGN: Nonintervention cohort study. SETTING: eICU Research Institute ICUs using tele-ICU software calculating continuous ICU Discharge Readiness Scores between January 2013 and March 2016. PATIENTS: Five hundred sixty-one thousand four hundred seventy-eight adult ICU patients with an ICU length of stay between 4 hours and 30 days...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29474314/severity-of-illness-measures-for-pediatric-inpatients
#15
Amanda J Hessels, Jianfang Liu, Bevin Cohen, Jingjing Shang, Elaine L Larson
INTRODUCTION: Severity of illness (SOI) measures are commonly used in adults for comparison of treatment and outcomes in similar populations. Less is known about the psychometric properties of measures available to providers and healthcare systems caring for pediatric patients. The purpose of this study was to (1) identify SOI measures used for pediatric patients admitted to acute care hospitals and (2) compare the ability of two SOI measures to predict mortality and length of stay (LOS)...
February 16, 2018: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29474266/recovery-from-schizophrenia-is-it-possible
#16
Antonio Vita, Stefano Barlati
PURPOSE OF REVIEW: Schizophrenia has a heterogeneous range of end states, from severe cases requiring repeated hospitalization to cases in which a single illness episode is followed by complete remission. The purpose of the present review is to examine recent literature on recovery in schizophrenia, focusing on the predictive factors and on the possibility to achieve it. RECENT FINDINGS: Roughly half of schizophrenia patients recovered or significantly improved over the long term, suggesting that functional remission is possible...
February 22, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29474265/global-mental-health-and-schizophrenia
#17
Laura Asher, Abebaw Fekadu, Charlotte Hanlon
PURPOSE OF REVIEW: The aim was to synthesize recent evidence on schizophrenia illness experience and outcomes and models of care in low and middle-income countries (LMICs). RECENT FINDINGS: There is a plurality of explanatory models for psychosis and increasing evidence that context influences experiences of stigma. People with schizophrenia in LMICs are vulnerable to food insecurity, violence and physical health problems, in addition to unmet needs for mental healthcare...
February 22, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29474231/clinical-and-serological-predictors-of-suicide-in-schizophrenia-and-major-mood-disorders
#18
Faith Dickerson, Andrea Origoni, Lucy A B Schweinfurth, Cassie Stallings, Christina L G Savage, Kevin Sweeney, Emily Katsafanas, Holly C Wilcox, Sunil Khushalani, Robert Yolken
Persons with serious mental illness are at high risk for suicide, but this outcome is difficult to predict. Serological markers may help to identify suicide risk. We prospectively assessed 733 persons with a schizophrenia spectrum disorder, 483 with bipolar disorder, and 76 with major depressive disorder for an average of 8.15 years. The initial evaluation consisted of clinical and demographic data as well as a blood samples from which immunoglobulin G antibodies to herpes viruses and Toxoplasma gondii were measured...
March 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29474229/but-you-re-not-a-real-doctor-i-mean-dealing-with-life-threatening-illnesses
#19
John A Talbott
No abstract text is available yet for this article.
March 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29474221/profound-visual-recovery-at-16-months-after-resolution-of-serous-retinal-detachments-secondary-to-thrombotic-thrombocytopenic-purpura-case-report-and-literature-review
#20
Parker J Williams, William A Pearce, Jesse M Smith, Joshua Robinson
PURPOSE: To report a unique case of dramatic improvement in objective visual function during the recovery phase, after resolution of thrombotic thrombocytopenic purpura-related serous retinal detachments and to review prognostic trends in reported cases involving the macula. METHODS: Observational case report and literature review. RESULTS: A 36-year-old white woman with thrombotic thrombocytopenic purpura developed vision loss from serous retinal detachments in both eyes...
February 22, 2018: Retinal Cases & Brief Reports
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