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https://www.readbyqxmd.com/read/29779702/vitamin-d-is-not-useful-as-a-biomarker-for-disease-activity-in-rheumatoid-arthritis
#1
Paola de la Torre Lossa, Mario Moreno Álvarez, María Del Carmen González Guzmán, Rafael López Martínez, Carlos Ríos Acosta
OBJECTIVE: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA). METHODOLOGY: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months...
May 17, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29776017/pharmacokinetics-and-c-reactive-protein-modelling-of-anti-il-6-antibody-pf-04236921-in-healthy-volunteers-and-patients-with-autoimmune-disease
#2
Cheryl Li, Satoshi Shoji, Jean Beebe
AIMS: The purpose of this study was to characterize pharmacokinetics (PK) of PF-04236921, a novel anti-IL-6 monoclonal antibody, and its pharmacokinetics/pharmacodynamics (PK/PD) relationship on serum C-Reactive Protein (CRP) in healthy volunteers and patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Crohn's disease (CD) METHODS: Population modelling analyses were conducted using nonlinear mixed effects modelling. Data from 2 phase 1 healthy volunteer studies, a phase 1 RA study, a Phase 2 CD study, and a Phase 2 SLE study were included...
May 18, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29774240/mannan-induced-nos2-in-macrophages-enhances-il-17-driven-psoriatic-arthritis-by-innate-lymphocytes
#3
Jianghong Zhong, Tatjana Scholz, Anthony C Y Yau, Simon Guerard, Ulrike Hüffmeier, Harald Burkhardt, Rikard Holmdahl
Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive oxygen species (ROS), we found that NO was detectable before disease onset in mice, independent of a functional nicotinamide adenine dinucleotide phosphate oxidase 2 complex. MIP was suppressed by either deletion of Nos2 or inhibition of NO synthases with NG-nitro-l-arginine methyl ester, demonstrating that Nos2-derived NO is pathogenic...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29773450/acromioclavicular-joint-septic-arthritis-in-an-immunocompetent-child-a-case-report
#4
Saurabh Dutt, Jeetendra Lodhi, Vinod Kumar, Abhishek Kashyap
Septic arthritis of acromioclavicular (AC) joint is a rare entity. It is generally seen in patients who are immunocompromised. Only 15 cases have been reported till now, with only one case series of 6 patients. We report a case of septic arthritis of AC joint in an immunocompetent child. A 9 years old girl presented with history of pain in left shoulder for 4 days associated with fever. No history suggestive of any immunocompromised state was complained. On local examination, a swelling of around 3 cm in diameter was found over left AC joint region with raised local temperature, tenderness on palpation and positive response in fluctuation test...
March 23, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29773003/antioxidant-action-of-an-aqueous-extract-of-royal-sun-medicinal-mushroom-agaricus-brasiliensis-agaricomycetes-in-rats-with-adjuvant-induced-arthritis
#5
Aline Cristine da Silva de Souza, Geferson de Almeida Gonсalves, Andréia Assunсão Soares, Anacharis B de Sá-Nakanishi, Ana Paula de Santi-Rampazzo, Maria Raquel Marсal Natali, Rosane Marina Peralta, Adelar Bracht
The purpose of this study was to evaluate possible effects of the administration of an aqueous Agaricus brasiliensis extract on the oxidative state of the liver, brain, and plasma in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Daily doses of 400 mg · kg-1 were administered by gavage for 23 days. This treatment produced significant diminutions in protein carbonylation and lipid damage in the liver, brain, and plasma. It also diminished the tissue reactive oxygen species and increased the antioxidant capacity of the plasma...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29770539/hepatitis-b-virus-reactivation-in-patients-with-rheumatoid-arthritis-analysis-of-the-national-database-of-japan
#6
Misuzu Fujita, Masaya Sugiyama, Yasunori Sato, Kengo Nagashima, Sho Takahashi, Masashi Mizokami, Akira Hata
This study aimed to determine the incidence and risk factors for hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis (RA) undergoing immunosuppressive therapy. The National Database of Japan, in which insurance claim data have been comprehensively accumulated, was utilized. The subjects were 76,641 RA patients who were plausibly initiated on immunosuppressive therapy from April 2013 to March 2014. Laboratory tests of the hepatitis B surface antigen, anti-hepatitis B virus surface antibody, and anti-hepatitis B virus core antibody were performed in 28...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29765870/low-starting-dosage-of-infliximab-with-possible-escalating-dosage-in-psoriatic-arthritis-gives-the-same-treatment-results-as-standard-dosage-of-adalimumab-or-etanercept-results-from-the-nationwide-icelandic-icebio-registry
#7
Bjorn Gudbjornsson, Arni Jon Geirsson, Niels Steen Krogh
Objective: To explore differences in response to a low dosage regimen of infliximab with an escalating dosage in comparison to a standard dosage of etanercept and adalimumab in patients with psoriatic arthritis (PsA). Methods: Biologically naïve PsA patients who were beginning anti-TNF-α therapy were selected from the ICEBIO registry. Demographics and clinical differences were compared in four treatment groups: infliximab <4 mg/kg; infliximab >4 mg/kg; etanercept or adalimumab at baseline and on follow-up (6 and 12 months, last visit)...
2018: Psoriasis: targets and therapy
https://www.readbyqxmd.com/read/29765284/influence-of-serum-leptin-levels-and-q223r-leptin-receptor-polymorphism-on-clinical-characteristic-of-patients-with-rheumatoid-arthritis-from-western-mexico
#8
Luis I Angel-Chávez, Elizabeth Ruelas-Cinco, Jorge Hernández-Bello, Elena Castro, Mirna Vázquez-Villamar, Isela Parra-Rojas, L Michele Brennan-Bourdon, Salvador Muñoz-Barrios, Celia Guerrero-Velázquez, José Francisco Muñoz-Valle
Objective: The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods: A cross-sectional study was performed with 70 RA patients and 74 controls subject (CS). Disease activity was evaluated using DAS28 score, the Q223R LEPR polymorphism was determined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and serum leptin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) were quantified...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29761420/long-term-radiographic-and-patient-reported-outcomes-in-patients-with-rheumatoid-arthritis-treated-with-tofacitinib-oral-start-and-oral-scan-post-hoc-analyses
#9
Vibeke Strand, Arthur Kavanaugh, Alan J Kivitz, Désirée van der Heijde, Kenneth Kwok, Ermeg Akylbekova, Arif Soonasra, Mark Snyder, Carol Connell, Eustratios Bananis, Josef S Smolen
INTRODUCTION: Here we examine the relationship between achieving different levels of disease activity with tofacitinib (an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis), long-term structural progression, and patient-reported physical function. METHODS: This was a post hoc analysis of two 24-month, phase III randomized controlled trials in methotrexate (MTX)-naïve (ORAL Start [NCT01039688]) or MTX-inadequate responder (IR) patients (ORAL Scan [NCT00847613]) receiving tofacitinib 5 or 10 mg twice daily as either monotherapy or with background MTX...
May 14, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29759083/hypertrophic-osteoarthropathy-mimicking-a-reactive-arthritis-a-case-report-and-review-of-the-literature
#10
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti
BACKGROUND: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. CASE PRESENTATION: A 77-year-old man presented with fever, diarrhea, and an oligoarthritis involving the left knee and the ankles...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29755555/the-ethanolic-extract-of-eysenhardtia-polystachya-ort-sarg-bark-and-its-fractions-delay-the-progression-of-rheumatoid-arthritis-and-show-antinociceptive-activity-in-murine-models
#11
Saudy Saret Pablo-Pérez, Benjamín Parada-Cruz, Olivier Christophe Barbier, María Estela Meléndez-Camargo
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. The EE was administered orally at doses of 25, 50, 100, and 200 mg/kg/day, and its fractions at 25 mg/kg/day in all animal models...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29751165/no-association-between-consumption-of-sweetened-beverages-and-later-risk-of-crohn-s-disease-or-ulcerative-colitis
#12
Hamed Khalili, Niclas Hakansson, Simon S Chan, Jonas F Ludvigsson, Ola Olen, Andrew T Chan, Andrew R Hart, Alicja Wolk
BACKGROUND & AIMS: Consumption of sweetened beverages has been associated with inflammation, based on measurements of C-reactive protein and tumor necrosis factor, as well as immune-mediated disorders including rheumatoid arthritis. We investigated associations with Crohn's disease (CD) or ulcerative colitis (UC). METHODS: We conducted a prospective cohort study of 83,042 participants (44-83 years old) enrolled in the Cohort of Swedish Men or the Swedish Mammography Study...
May 8, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29750059/serum-il-6-correlates-with-axial-mobility-index-bath-ankylosing-spondylitis-metrology-index-in-brazilian-patients-with-ankylosing-spondylitis
#13
Cristina F Rabelo, Talita Siara Almeida Baptista, Laura Esteves Petersen, Moisés Evandro Bauer, Mauro Waldemar Keiserman, Henrique Luiz Staub
Introduction: Ankylosing spondylitis (AS) is a chronic disease featuring axial changes, peripheral arthritis and systemic involvement. Proinflammatory cytokines are probably involved in AS pathogenesis. The relationship of circulating cytokines with instruments of AS evaluation is an open field of research. Objective: The aim of this study was to compare serum levels of cytokines in AS patients and healthy controls, and search for correlations of cytokines with indexes of disease activity and quality of life...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29744553/changes-in-mirna-5196-expression-as-a-potential-biomarker-of-anti-tnf-%C3%AE-therapy-in-rheumatoid-arthritis-and-ankylosing-spondylitis-patients
#14
Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, Patryk Zarecki, Jerzy Swierkot, Piotr Gluszko, Katarzyna Bogunia-Kubik, Wlodzimierz Maslinski
In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Disease activity of RA patients was assessed using disease activity score 28 (DAS28), whereas ankylosing spondylitis DAS (ASDAS) was used in AS patients...
May 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29744123/erythema-nodosum-as-sign-of-primary-tuberculosis
#15
Eleftherios Kritsotakis
Erythema nodosum is a panniculitis associated with numerous diseases such as infections, inflammatory diseases, tuberculosis or can be idiopathic. We here report a case of a woman with erythema nodosum and reactive arthritis who was subsequently diagnosed with tuberculosis. A high level of suspicion and a thorough clinical and laboratory investigation of the patient presenting with erythema nodosum is required, in order to detect a possible systemic underlying condition.
August 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29744120/a-case-of-reactive-arthritis-secondary-to-sexually-acquired-shigella-flexneri
#16
Sarah L Kennedy, Jennifer Murira, Claire Y Wenham
We present the first documented case of reactive arthritis (ReA) secondary to sexually acquired Shigella flexneri infection. The case occurred in the context of a recent change in Shigella epidemiology in England where non-travel associated cases are now contributing the majority of diagnoses. Such non-travel associated cases are occurring predominantly in men who have sex with men with high sexual risk taking behaviour reflecting the importance of the sexual history when assessing a man with Shigella infection who has not travelled...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#17
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29736870/can-we-predict-thrombotic-tendency-in-rheumatoid-arthritis-a-thromboelastographic-analysis-with-rotem
#18
Sümeyye Merve Türk, Döndü Üsküdar Cansu, Hava Üsküdar Teke, Timuçin Kaşifoğlu, O Meltem Akay, Muzaffer Bilgin, Cengiz Korkmaz
The higher incidence of arterial and venous events is well established in patients with rheumatoid arthritis (RA). Our aim here was to investigate whether there is a prothrombotic state in RA patients by using rotational thromboelastometry (ROTEM) method and to demonstrate whether the disease variables play a role in this process. A total of 85 patients who met the 2010 RA classification criteria were consecutively included in the study. The patients with RA who have been using antiaggregant, anticoagulant, or nonsteroidal anti-inflammatory drugs (NSAIDs) and had a history of arterial or venous thromboembolism were excluded from the study...
May 7, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29724244/does-psychological-stress-in-patients-with-clinically-suspect-arthralgia-associate-with-subclinical-inflammation-and-progression-to-inflammatory-arthritis
#19
Aleid C Boer, Robin M Ten Brinck, Andrea W M Evers, Annette H M van der Helm-van Mil
BACKGROUND: Within established rheumatoid arthritis (RA), stress can have pro-inflammatory effects by activating the immune system via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. It is unknown if stress levels also promote inflammation during RA development. We studied whether the psychological stress response was increased in clinically suspect arthralgia (CSA) and if this associated with inflammation at presentation with arthralgia and with progression to clinical arthritis...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29723366/metabolic-syndrome-c-reactive-protein-and-cardiovascular-risk-in-psoriasis-patients-a-cross-sectional-study
#20
Renato Soriani Paschoal, Daniela Antoniali Silva, Renata Nahas Cardili, Cacilda da Silva Souza
BACKGROUND: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk. OBJECTIVES: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity. METHODS: In this cross-sectional study, plaque Psoriasis patients (n=90), distributed equally in gender, were analyzed according to: Psoriasis Area and Severity Index, cardiovascular risk determined by the Framingham risk score and global risk assessment, C-reactive protein and metabolic syndrome criteria (NCEPT-ATP III)...
March 2018: Anais Brasileiros de Dermatologia
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