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Reactive arthritis

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https://www.readbyqxmd.com/read/28628468/dapsa-das28-and-mda-predict-long-term-treatment-regime-in-psoriatic-arthritis-the-swedish-early-psoriatic-arthritis-cohort
#1
Ulla Lindqvist, Mona-Lisa Wernroth, Tomas Husmark, Per Larsson, Mats Geijer, Annika Teleman, Elke Theander, Gerd-Marie Alenius
OBJECTIVES: To describe treatment patterns in the Swedish early psoriatic arthritis cohort (SwePsA) of the mono-/oligo-arthritic (M/O) and polyarthritis (P) and identify early predictive factors for treatment with disease-modifying anti-rheumatic (DMARD), non-steroidal anti-inflammatory drugs (NSAID), and tumour necrosis factor inhibition (TNFi) after 5 years. METHODS: Data for 198 M/O and P PsA were obtained within the programme for SwePsA. Multinomial and binary logistic regression analyses were used to assess the association between early predictive factors and treatment after 5 years adjusted for age at inclusion...
June 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28623003/serum-procalcitonin-levels-as-a-diagnostic-marker-for-septic-arthritis-a-meta-analysis
#2
Jingyi Zhao, Shufeng Zhang, Lei Zhang, Xianhui Dong, Jianhui Li, Ying Wang, Yinhui Yao
BACKGROUND: The aim of this study was to assess the value of serum procalcitonin (PCT) levels as a diagnostic marker for septic arthritis (SA) via meta-analysis. METHODS: We searched PubMed, Embase and the Cochrane Library, as well as the reference lists of relevant articles, for studies published up to May 21, 2015 and did not impose language restrictions. We selected original studies reporting the usefulness of PCT or C-reactive protein (CRP) as a diagnostic marker for SA...
June 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28619676/peroxynitrite-modified-histone-as-a-pathophysiological-biomarker-in-autoimmune-diseases
#3
REVIEW
Md Asad Khan, Khursheed Alam, Md Zafaryab, M Moshahid A Rizvi
Under physiological conditions, reactive nitrogen and oxygen species are produced continuously. However, excess of these radicals may damage biomolecules like lipids, proteins and nucleic acids. These reactive species have been implicated in many disease conditions including acute/chronic inflammation, rheumatoid arthritis (RA), neurodegenerative diseases and systemic lupus erythematosus (SLE). Peroxynitrite, an oxidant and nitrating molecule, formed in in vivo, when nitric oxide reacts with superoxide radical...
June 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28618429/microarray-expression-profile-of-circular-rnas-in-peripheral-blood-mononuclear-cells-from-rheumatoid-arthritis-patients
#4
Qingqing Ouyang, Jing Wu, Zhenlan Jiang, Jinjun Zhao, Ran Wang, Aiju Lou, Dingji Zhu, Guo-Ping Shi, Min Yang
BACKGROUND/AIMS: Circular RNAs (circRNAs) compose a large class of RNAs that can be used as biomarkers in clinical blood samples. This study aimed to determine the expression of circRNAs in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients to identify novel biomarkers for RA screening. METHODS: We started with a microarray screening of circRNA changes in PBMCs from 5 RA patients and 5 healthy controls. We then confirmed the selected circRNA changes in PBMCs from 30 RA patients and 25 age- and sex-matched controls using the real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
June 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28615124/blood-and-milk-polymorphonuclear-leukocyte-and-monocyte-macrophage-functions-in-naturally-caprine-arthritis-encephalitis-virus-infection-in-dairy-goats
#5
Bruna Parapinski Santos, Fernando Nogueira Souza, Maiara Garcia Blagitz, Camila Freitas Batista, Heloísa Godoi Bertagnon, Soraia Araújo Diniz, Marcos Xavier Silva, João Paulo Amaral Haddad, Alice Maria Melville Paiva Della Libera
The exact influence of caprine arthritis encephalitis virus (CAEV) infection on blood and milk polymorphonuclear leukocytes (PMNLs) and monocyte/macrophages of goats remains unclear. Thus, the present study sought to explore the blood and milk PMNL and monocyte/macrophage functions in naturally CAEV-infected goats. The present study used 18 healthy Saanen goats that were segregated according to sera test outcomes into serologically CAEV negative (n=8; 14 halves) and positive (n=10; 14 halves) groups. All milk samples from mammary halves with milk bacteriologically positive outcomes, somatic cell count ≥2×10(6)cellsmL(-1), and abnormal secretions in the strip cup test were excluded...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28615036/predictors-of-the-response-to-etanercept-in-patients-with-juvenile-idiopathic-arthritis-without-systemic-manifestations-within-12-months-results-of-an-open-label-prospective-study-conducted-at-the-national-scientific-and-practical-center-of-children-s-health
#6
Ekaterina I Alexeeva, Leyla S Namazova-Baranova, Tatyana M Bzarova, Saniya I Valieva, Rina V Denisova, Tatyana V Sleptsova, Kseniya B Isaeva, Alexandra M Chomahidze, Nikolay I Taibulatov, Anna N Fetisova, Anna V Karaseva, Alexandr A Baranov
BACKGROUND: The aim of this study was to investigate the efficacy of etanercept treatment and to identify predictors of response to therapy within 12 months in patients with juvenile idiopathic arthritis (JIA) without systemic manifestations. METHODS: A total of 197 juvenile patients were enrolled in this study. Response to therapy was assessed using the ACRPedi 30/50/70/90 criteria, the Wallace criteria, and the Juvenile Arthritis Disease Activity Score 71 (JADAS-71)...
June 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28612349/role-of-hydrotherapy-in-the-amelioration-of-oxidant-antioxidant-status-in-rheumatoid-arthritis-patients
#7
Somaiya Mateen, Shagufta Moin, Abdul Q Khan, Atif Zafar, Naureen Fatima, Sumayya Shahzad
AIM: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease. Reactive oxygen species (ROS) are involved in the pathophysiology of RA. Moderate intensity exercises have been reported to have anti-oxidant and anti-inflammatory effects. The aim of this study was to evaluate the effect of hydrotherapy on oxidant-antioxidant status in RA patients. METHODS: Forty RA patients and 30 age- and sex-matched healthy controls were included in this study. RA patients were subdivided into two groups: the first group (n = 20) received treatment with conventional RA drugs, while the second group (n = 20) received hydrotherapy along with the conventional drugs for a period of 12 weeks...
June 14, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28612240/clinical-characteristics-of-peripheral-spondyloarthritis-without-psoriasis-inflammatory-enteropathy-or-preceding-infection-from-a-single-rheumatology-clinic-in-northern-india
#8
Anand Narayan Malaviya, Neha Agrawal, Nilesh Sahebrao Patil
The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broad spectrum of SpA were screened for the presence of peripheral arthritis using the Assessment of SpondyloArthritis International Society (ASAS) criteria. The other conditions that could cause pSpA, e...
June 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28612179/efficacy-safety-and-pharmacokinetics-of-up-to-two-courses-of-the-rituximab-biosimilar-ct-p10-versus-innovator-rituximab-in-patients-with-rheumatoid-arthritis-results-up-to-week-72-of-a-phase-i-randomized-controlled-trial
#9
Dae Hyun Yoo, Chang-Hee Suh, Seung Cheol Shim, Slawomir Jeka, Francisco Fidencio Cons Molina, Pawel Hrycaj, Piotr Wiland, Eun Young Lee, Francisco G Medina-Rodriguez, Pavel Shesternya, Sebastiao Radominski, Marina Stanislav, Volodymyr Kovalenko, Dong Hyuk Sheen, Leysan Myasoutova, Mie Jin Lim, Jung-Yoon Choe, Sang Joon Lee, Sung Young Lee, Sung Hwan Kim, Won Park
BACKGROUND: CT-P10 is a biosimilar of innovator rituximab (RTX), a biological therapy used to treat patients with rheumatoid arthritis (RA) who have responded inadequately to anti-tumor necrosis factor agents. OBJECTIVE: Our objective was to compare the clinical profile of CT-P10 versus RTX in patients with RA who received up to two courses of treatment and were followed for up to 72 weeks. METHODS: In this multicenter double-blind phase I study, patients were randomized 2:1 to receive CT-P10 1000 mg or RTX 1000 mg at weeks 0 and 2...
June 13, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28611632/infliximab-induced-aseptic-meningitis-during-the-treatment-of-psoriatic-arthritis
#10
Yuki Matsuura-Otsuki, Takaaki Hanafusa, Hiroo Yokozeki, Kyoko Watanabe
A 42-year-old Japanese man presented with persistent headache during treatment for psoriatic arthritis (PsA) with infliximab. Treatment with infliximab was initiated 3 years before and the psoriatic skin lesions with arthritis were well controlled. However, after 21 doses of infliximab, the skin lesions and joint pain exacerbated and became intractable. Ten days after the dosage of infliximab was increased, the patient experienced headache and nausea with high fever. He had scaly, well-circumscribed erythemas on his trunk, extremities, and deformed nails...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28611162/a-large-chronic-pericardial-effusion-in-an-ultramarathon-runner-with-anti-ccp-positive-rheumatoid-arthritis
#11
Thomas J McClelland, Rose Penfold, Stefan Kluzek, Navraj S Nagra
Pericardial effusions arise as an extra-articular manifestation of rheumatoid arthritis (RA). Pericardial effusions are often asymptomatic, particularly in the early phase, but patients are at risk of cardiac tamponade as the effusion progresses. We discuss the case of a 40-year-old male ultramarathon runner with RA who presented with mild pleuritic chest pain and exertional dyspnoea after a recent long-haul flight. Despite a relative tachycardia, his observations were otherwise unremarkable. His blood tests revealed a C-reactive protein (CRP) of 86 mg/L and an anti-cyclic citrullinated peptide (anti-CCP) titre of 360 units/mL...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28611080/magnetic-resonance-imaging-assessed-inflammation-in-the-wrist-is-associated-with-patient-reported-physical-impairment-global-assessment-of-disease-activity-and-pain-in-early-rheumatoid-arthritis-longitudinal-results-from-two-randomised-controlled-trials
#12
Daniel Glinatsi, Joshua F Baker, Merete L Hetland, Kim Hørslev-Petersen, Bo J Ejbjerg, Kristian Stengaard-Pedersen, Peter Junker, Torkell Ellingsen, Hanne M Lindegaard, Ib Hansen, Tine Lottenburger, Jakob M Møller, Lykke Ørnbjerg, Aage Vestergaard, Anne Grethe Jurik, Henrik S Thomsen, Trine Torfing, Signe Møller-Bisgaard, Mette B Axelsen, Mikkel Østergaard
OBJECTIVES: To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS: Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up...
June 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28608433/performances-of-clinical-disease-activity-index-cdai-and%C3%A2-simplified-disease-activity-index-sdai-appear-to-be-better-than-the-gold-standard-disease-assessment-score-das-28-crp-to-assess-rheumatoid-arthritis-patients
#13
Pooja Dhaon, Siddharth K Das, Ragini Srivastava, Urmila Dhakad
BACKGROUND/PURPOSE: To compare the performance of Disease Assessment Score of 28 joints - C-reactive protein (DAS-28-CRP), Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) composite measures to assess status of patients with rheumatoid arthritis (RA) on methotrexate, versus DAS-28 CRP as the gold standard. METHODS: One hundred and thirty-five patients with RA as per the 2010 American College of Rheumatology/European League Against Rheumatism criteria were included in the prospective study...
June 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28607793/the-case-of-reactive-arthritis-secondary-to-echinococcus-infestation
#14
Bülent Alım, Sinan Çetinel, M Alperen Servi, Fahrettin Bostancı, Mehmet Ozan Bingöl
Reactive arthritis is an inflammatory joint disease that develops after an infection and it usually occurs following a gastrointestinal or genitourinary system infection and it belongs to the family of arthritis called "spondyloarthritis." We wanted to represent a rare case of reactive arthritis secondary to Echinococcus infestation. Cyst hydatid disease is common in endemic regions like Turkey. Internal organ involvements, especially liver and lung, are most frequent involvements. Primary bone involvement is rare complication of Echinococcus infestation...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28606966/obesity-and-rates-of-clinical-remission-and-low-mri-inflammation-in-rheumatoid-arthritis
#15
Michael D George, Mikkel Østergaard, Philip G Conaghan, Paul Emery, Daniel G Baker, Joshua F Baker
OBJECTIVES: Obesity has been proposed as a risk factor for refractory rheumatoid arthritis (RA). We evaluated the impact of obesity on achieving clinical and imaging definitions of low disease activity. METHODS: This study evaluated 470 patients with RA from GO-BEFORE and GO-FORWARD randomised clinical trials. Included patients had blinded clinical disease activity measures and MRI at baseline, 24 and 52 weeks. Synovitis, osteitis and total inflammation scores were determined using the RA MRI scoring system...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606961/long-term-outcomes-after-disease-activity-guided-dose-reduction-of-tnf-inhibition-in-rheumatoid-arthritis-3-year-data-of-the-dress-study-a-randomised-controlled-pragmatic-non-inferiority-strategy-trial
#16
Chantal Am Bouman, Noortje van Herwaarden, Frank Hj van den Hoogen, Jaap Fransen, Ronald F van Vollenhoven, Johannes Wj Bijlsma, Aatke van der Maas, Alfons A den Broeder
OBJECTIVE: Tumour necrosis factor inhibitors (TNFi) are effective in rheumatoid arthritis (RA), but disadvantages include adverse events (AEs) and high costs. This can be improved by disease activity-guided dose reduction (DR). We aimed to assess long-term outcomes of TNFi DR in RA by using 3-year data from the DRESS study (Dose REduction Strategy of Subcutaneous TNF inhibitors study). METHODS: In the intervention phase (month 0-18) of the DRESS study (Dutch trial register, NTR 3216), patients were randomised to DR or usual care (UC)...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606166/poncet-s-disease-in-human-immunodeficiency-virus-a-case-report
#17
Enoch Omonge, Fredrick Otieno, Mary Kubo, Betty Shiruli
BACKGROUND: Poncet's disease is a rare reactive polyarthritis associated with active tuberculosis and no evidence of Mycobacterium tuberculosis in the affected joint. CASE PRESENTATION: We report a case of a 35 year old Human Immunodeficiency Virus positive Kenyan male of Kikuyu ethnicity from Kiambu County who presented to hospital with a 6 day history of bilateral knee pain and swelling, bilateral ankle pain with right ankle swelling. The patient reported 6 months history of cough and weight loss...
June 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28604559/wellbeing-and-arthritis-incidence-the-role-of-inflammatory-mechanisms-findings-from-the-english-longitudinal-study-of-ageing
#18
Judith A Okely, Alexander Weiss, Catharine R Gale
OBJECTIVE: Higher wellbeing is associated with lower levels of inflammatory markers in healthy populations; however, it is unclear whether this association translates into a reduced risk of disease. In the current study, we tested whether the association between wellbeing and inflammation results in a lower risk of arthritis. METHODS: The sample consisted of 5,622 participants aged ≥ 50 from the English Longitudinal Study of Ageing and included 6 waves of data collection...
June 10, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28594861/level-of-inflammatory-cytokines-in-rheumatoid-arthritis-patients-correlation-with-25-hydroxy-vitamin-d-and-reactive-oxygen-species
#19
Somaiya Mateen, Shagufta Moin, Sumayya Shahzad, Abdul Qayyum Khan
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Reactive oxygen species (ROS) and pro-inflammatory cytokines have been believed to be involved in the etiopathogenesis of the disease. The aim of the study was to determine the correlation of inflammatory cytokines with 25-hydroxy vitamin D and ROS. METHODS: 100 RA patients and 50 healthy age and sex matched individuals were included in the study. Patients were further divided on the basis of presence or absence of rheumatoid factor and disease severity...
2017: PloS One
https://www.readbyqxmd.com/read/28593608/tumor-necrosis-factor-%C3%AE-308-a-g-gene-polymorphism-in-children-with-juvenile-idiopathic-arthritis-relation-to-disease-activity-damage-and-functional-status
#20
Iman I El Gazzar, Hanan M Fathy, Tamer A Gheita, Abeer M Nour El-Din, Enas Abdel Rasheed, Rasha H Bassyouni, Sanaa A Kenawy
The study aims to evaluate the clinical significance of serum levels of tumor necrosis factor alpha (TNF-α) and -308 A/G promoter polymorphism in juvenile idiopathic arthritis (JIA) patients and find any association to the subsets, clinical and laboratory features, disease activity, and damage as well as functional disability. Forty-eight JIA children and 30 controls were included in the present study. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated, juvenile arthritis damage index (JADI) was assessed, and Childhood Health Assessment Questionnaire (CHAQ) measured the functional status...
June 7, 2017: Clinical Rheumatology
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