keyword
MENU ▼
Read by QxMD icon Read
search

Reactive arthritis

keyword
https://www.readbyqxmd.com/read/28215033/anti-mutated-citrullinated-vimentin-antibodies-in-antiphospholipid-syndrome-diagnostic-value-and-relationship-with-clinical-features
#1
Cristiano Alessandri, Nancy Agmon-Levin, Fabrizio Conti, Carlo Perricone, Elena Ortona, Monica Pendolino, Antonella Capozzi, Federica Delunardo, Riccardo Mancini, Simona Truglia, Francesca Romana Spinelli, Fulvia Ceccarelli, Maurizio Sorice, Yehuda Shoenfeld, Guido Valesini
: Antiphospholipid antibodies (aPLs) are a heterogeneous group of autoantibodies essential for the diagnosis of antiphospholipid syndrome (APS) but do not predict clinical manifestations or disease progression. Hence, the co-presence of other antibodies may prove useful. Autoimmunity directed toward vimentin and other citrullinated peptides was established in rheumatoid arthritis (RA) and in other autoimmune conditions including systemic lupus erythematosus (SLE). We have previously described the presence of autoantibodies directed against vimentin/cardiolipin complex in patients with antiphospholipid syndrome (APS), but there are no data on the role of citrullinated vimentin in APS...
February 18, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28213794/selected-cytokine-pathways-in-rheumatoid-arthritis
#2
REVIEW
Mélissa Noack, Pierre Miossec
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction. Cytokines play a key role in its pathogenesis. They contribute to the induction and maintenance of inflammation and thus provide therapeutic targets. Many cytokines are involved in RA, and this review focuses on a few critical ones: tumor necrosis factor (TNF), interleukin (IL)-6, IL-1, IL-17, and GM-CSF. TNF and IL-6 are both well-established targets in RA treatment, and new biologic agents are reaching the market. IL-1 represents a more complex cytokine as results in humans do not reach those in animal models...
February 17, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28213566/a-randomised-phase-iib-study-of-mavrilimumab-a-novel-gm-csf-receptor-alpha-monoclonal-antibody-in-the-treatment-of-rheumatoid-arthritis
#3
Gerd R Burmester, Iain B McInnes, Joel Kremer, Pedro Miranda, Mariusz Korkosz, Jiri Vencovsky, Andrea Rubbert-Roth, Eduardo Mysler, Matthew A Sleeman, Alex Godwood, Dominic Sinibaldi, Xiang Guo, Wendy I White, Bing Wang, Chi-Yuan Wu, Patricia C Ryan, David Close, Michael E Weinblatt
OBJECTIVES: Despite the therapeutic value of current rheumatoid arthritis (RA) treatments, agents with alternative modes of action are required. Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, was evaluated in patients with moderate-to-severe RA. METHODS: In a phase IIb study (NCT01706926), patients with inadequate response to ≥1 synthetic disease-modifying antirheumatic drug(s), Disease Activity Score 28 (DAS28)-C reactive protein (CRP)/erythrocyte sedimentation rate ≥3...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28213565/anti-tnf-induced-remission-in-very-early-peripheral-spondyloarthritis-the-crespa-study
#4
Philippe Carron, Gaëlle Varkas, Heleen Cypers, Liesbet Van Praet, Dirk Elewaut, Filip Van den Bosch
OBJECTIVE: To evaluate the efficacy and safety of golimumab to induce clinical remission in patients with very early, active peripheral spondyloarthritis (pSpA). METHODS: Clinical REmission in peripheral SPondyloArthritis is a monocentric study of golimumab treatment in patients with pSpA. All patients fulfilled the Assessment of SpondyloArthritis international Society classification criteria for pSpA, with a symptom duration ≤12 weeks. Patients were randomised 2:1 to receive golimumab 50 mg every 4 weeks or matching placebo for 24 weeks...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28213564/seven-year-tolerability-profile-of-glucocorticoids-use-in-early-rheumatoid-arthritis-data-from-the-espoir-cohort
#5
Camille Roubille, Nathalie Rincheval, Maxime Dougados, René-Marc Flipo, Jean-Pierre Daurès, Bernard Combe
OBJECTIVE: To explore the 7-year tolerability profile of glucocorticoids (GC) for early rheumatoid arthritis (RA). METHODS: We examined data for 602 patients with RA from the early arthritis Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort (<6 months disease duration) stratified into two groups: with or without GC treatment at least once during follow-up (median 7 years (IQR 0.038-7.65)). The main outcome was a composite of death, cardiovascular disease (including myocardial ischaemia, cerebrovascular accident and heart failure), severe infection and fracture...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28207572/cross-reactivity-of-chloroquine-and-hydroxychloroquine-with-dri-amphetamine-immunoassay
#6
Isabel Gomila, Loreto Quesada, Victoria López-Corominas, Julia Fernández, Miguel Ángel Servera, Laura Sahuquillo, Macarena Dastis, Albert Torrents, Bernardino Barceló
BACKGROUND: Chloroquine and hydroxychloroquine are medical drugs used to treat the chemoprophylaxis of malaria as well as a second-line anti-inflammatory drug. METHODS: We performed a study of cross-reactivity of chloroquine and hydroxychloroquine in the DRI Amphetamine Assay inspired by a case report of a self-ingestion of chloroquine following a family dispute, that involved the following: (a) an in vitro study with control samples of healthy subjects, (b) an in vivo study with samples of patients with rheumatoid arthritis, and (c) an evaluation of the cross-reactivity of chloroquine and hydroxychloroquine in three additional immunoassays...
February 14, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28207326/micro-rna-146a-but-not-irak1-is-associated-with-rheumatoid-arthritis-in-the-tunisian-population
#7
Hana Ben Hassine, Asma Boumiza, Rim Sghiri, Khadija Baccouche, Imen Boussaid, Ahlem Atig, Zahid Shakoor, Elyes Bouajina, Ramzi Zemni
BACKGROUND: Rheumatoid arthritis (RA) is characterized by the production of an array of proinflammatory cytokines through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Interleukin-1 receptor (IL-1R) and Toll-like receptors contain a common cytoplasmic motif the Toll/IL-1R (TIR) homology domain. This motif is required for NF-κB activation. IL-1R-associated kinase 1 (IRAK1) is a key adapter molecule recruited during the signaling cascade of the TIR...
February 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28205390/circulating-adiponectin-and-visfatin-levels-in-rheumatoid-arthritis-and-their-correlation-with-disease-activity-a-meta-analysis
#8
Young Ho Lee, Sang-Cheol Bae
AIM: This study aimed to evaluate the relationship between circulating adiponectin and visfatin levels and rheumatoid arthritis (RA) and to establish a correlation between serum adipokine levels and RA activity. METHODS: We conducted meta-analyses on serum/plasma adiponectin or visfatin levels in patients with RA and controls and correlation coefficients between circulating adiponectin and visfatin levels and Disease Activity Score of 28 joints (DAS28) in RA patients...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28202118/-clinical-and-laboratory-features-of-macrophage-activation-syndrome
#9
Li Guo, Mei-Ping Lu, Gui-Juan Dong, Li-Ping Teng, Yi-Ping Xu, Li-Xia Zou, Qi Zheng
OBJECTIVE: To study the clinical and laboratory features of macrophage activation syndrome (MAS) at the early stage of diagnosis, and to explore a method for early identification of MAS. METHODS: A retrospective analysis was performed for the demographic data, clinical and laboratory features, and treatment outcomes of 21 MAS patients. RESULTS: Of the 21 MAS patients, 14 had systemic juvenile idiopathic arthritis, 5 had Kawasaki disease (KD), and 2 had connective tissue disease (CTD) as primary diseases...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28191607/retrospective-study-of-the-clinical-characteristics-and-risk-factors-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#10
Yongfeng Zhang, Hongbin Li, Nawei Wu, Xin Dong, Yi Zheng
This study aims to explore the clinical characteristics and risk factors of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). This is a retrospective study of 550 patients with RA. All patients underwent chest high-resolution computed tomography (HRCT) scanning. (1) Two hundred thirty-seven out of five hundred fifty (43.1%) patients with RA were diagnose with ILD. 13.5% ILD occurred before RA onset, 69.6% ILD occurred within 10 years of RA onset, and 16.9% ILD occurred more than 10 years after RA onset...
February 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28189039/low-dose-prednisolone-and-insulin-sensitivity-differentially-affect-arterial-stiffness-and-endothelial-function-an-open-interventional-and-cross-sectional-study
#11
Carolyn J Petersons, Brenda L Mangelsdorf, Anne Poljak, Malcolm D Smith, Jerry R Greenfield, Campbell H Thompson, Morton G Burt
BACKGROUND AND AIMS: Glucocorticoids could impair vascular function directly, or indirectly by reducing insulin sensitivity. The aim of this study was to determine the direct and indirect effects of acute and chronic low dose prednisolone on arterial stiffness and endothelial function. METHODS: Twelve subjects with inflammatory arthritis, who had not taken oral glucocorticoids for ≥6 months, and 12 subjects with inflammatory arthritis, taking chronic (>6 months) low dose (6...
January 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28183987/in-vivo-hypoxia-pet-imaging-quantifies-the-severity-of-arthritic-joint-inflammation-in-line-with-overexpression-of-hif-and-enhanced-ros-generation
#12
Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J Pichler, Manfred Kneilling
Hypoxia is essential for the development of autoimmune diseases such as rheumatoid arthritis (RA) and is associated with the expression of reactive oxygen species (ROS), due to enhanced infiltration of immune cells. The aim of this study was to demonstrate the feasibility of measuring hypoxia non-invasively in vivo in arthritic ankles with positron emission tomography (PET)/magnetic resonance imaging (MRI) using the hypoxia tracers (18)F-fluoromisonidazole (FMISO) and (18)F-fluoroazomycinarabinoside (FAZA)...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28183721/carbamylation-of-vimentin-is-inducible-by-smoking-and-represents-an-independent-autoantigen-in-rheumatoid-arthritis
#13
Caroline Ospelt, Holger Bang, Eugen Feist, Giovanni Camici, Stephan Keller, Jacqueline Detert, Anette Krämer, Steffen Gay, Khetam Ghannam, Gerd R Burmester
OBJECTIVES: Smoking has been connected to citrullination of antigens and formation of anti-citrullinated peptide antibodies (ACPAs) in rheumatoid arthritis (RA). Since smoking can modify proteins by carbamylation (formation of homocitrulline), this study was conducted to investigate these effects on vimentin in animal models and RA. METHODS: The efficiency of enzymatic carbamylation of vimentin was characterised. B-cell response was investigated after immunisation of rabbits with different vimentin isoforms...
February 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28183353/endothelial-injury-in-rheumatoid-arthritis-a-crosstalk-between-dimethylarginines-and-systemic-inflammation
#14
Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith, George D Kitas
BACKGROUND: Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA patients, but their correlation with assessments of endothelial function and structure remains unknown. We aimed to investigate whether SDMA and ADMA are associated with carotid intima media thickness (cIMT) and arterial stiffness as well as non-invasive assessments of in vivo micro- and macrovascular endothelial function in RA patients with high systemic inflammatory load...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28176230/inflammatory-markers-and-disease-activity-in-juvenile-idiopathic-arthritis
#15
Sumantra Sarkar, Md Mahboob Alam, Gargi Das, Supratim Datta
OBJECTIVE: To evaluate the post treatment changes in disease activity and inflammatory markers over time in longitudinal follow-up involving different subtypes of juvenile idiopathic arthritis (JIA) patients. METHODS: This prospective longitudinal study, carried out over a period of 2 y, included JIA patients, both old and new, with high disease activity. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, CHAQ (Childhood Health Assessment Questionnaire) score and JADAS27 (Juvenile Arthritis Disease Activity score with 27 active joint counts) were estimated at the initial visit, 6 mo, 12 mo and 18 mo of follow-up...
February 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28173737/failure-of-a-systemic-lupus-erythematosus-response-index-developed-from-clinical-trial-data-lessons-examined-and-learned
#16
L J Forbess, C Bresee, D J Wallace, M H Weisman
Background Our primary goal was to create an outcome change score index similar to a standard rheumatoid arthritis (RA) model utilizing real-world data in systemic lupus erythematosus (SLE) patients that occurred during their phase 3 trials with a Food and Drug Administration-approved drug. Methods We utilized raw data from trials of belimumab for the treatment of SLE. Data were split 80/20 into training/validation sets. Index variables present in a majority of patients and with face validity were selected...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28167912/c5a-regulates-il-1%C3%AE-production-and-leukocyte-recruitment-in-a-murine-model-of-monosodium-urate-crystal-induced-peritonitis
#17
Hanif J Khameneh, Adrian W S Ho, Federica Laudisi, Heidi Derks, Matheswaran Kandasamy, Baalasubramanian Sivasankar, Gim Gee Teng, Alessandra Mortellaro
Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β. MSU crystals also activate the complement system, which regulates the inflammatory response; however, it is unclear whether or how MSU-mediated complement activation is linked to IL-1β release in vivo, and the various roles that might be played by individual components of the complement cascade...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28164544/clinical-significance-of-red-blood-cell-distribution-width-and-inflammatory-factors-for-the-disease-activity-in-rheumatoid-arthritis
#18
Li Yunchun, Wang Yue, Fang Z Jun, Su Qizhu, Ding Liumei
BACKGROUND: To evaluate the significance of red blood cell distribution width (RDW) and other factors for the disease activity in rheumatoid arthritis (RA). METHODS: Each patient underwent clinical examination and blood sampling for assessment of serum high-sensitivity C-reactive protein (hs-CRP) levels, erythrocyte sedimentation rate (ESR), hemoglobin concentration (Hb), hematocrit (HCT), RDW, and other erythrocyte parameters (mean corpuscular volume [MCV], mean cell Hb [MCH], mean corpuscular Hb concentration [MCHC])...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28163961/the-adjuvant-use-of-calcium-fructoborate-and-borax-with-etanercept-in-patients-with-rheumatoid-arthritis-pilot-study
#19
Saad Abdulrahman Hussain, Sattar Jabir Abood, Faiq Isho Gorial
OBJECTIVE: This study was designed to evaluate the effects calcium fructoborate (CFB) and sodium tetraborate (NTB) as supplements in Iraqi patients with active rheumatoid arthritis (RA) maintained on etanercept. MATERIALS AND METHODS: A double-blind randomized placebo-controlled clinical trial with 60 days treatment period was carried out at Baghdad Teaching Hospital, Medical city, Baghdad, Iraq. Eighty RA patients were randomized into three groups to receive either 220 mg/day CFB, 55 mg/day NTB in capsule dosage form (equivalent to 6 mg elemental Boron), or placebo formula once daily...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28163195/positive-selection-of-type-ii-collagen-reactive-cd80-high-marginal-zone-b-cells-in-dba-1-mice
#20
Chanho Park, In Seong Kho, Jeong In Yang, Min-Jung Kim, Sunhoo Park, Hoon-Suk Cha, Jaejoon Lee, Tae Jin Kim
To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80(high) MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80(high) MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80(low) MZ B cells. Notably, the CD80(high) MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80(low) MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA)...
February 2, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
keyword
keyword
7551
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"