Jennifer Deane, Fiona Fouhy, Nicola J Ronan, Mary Daly, Claire Fleming, Joseph A Eustace, Fergus Shanahan, Evelyn T Flanagan, Lieven Dupont, Michael J Harrison, Charles S Haworth, Andres Floto, Mary C Rea, R Paul Ross, Catherine Stanton, Barry J Plant
PURPOSE: Clostridium difficile has been reported to occur in the gastrointestinal tract of 50% of Cystic Fibrosis (CF) subjects, however, clinical C. difficile infection (CDI) is a rare occurrence in this cohort despite the presence of toxigenic and hypervirulent ribotypes. Here, we present the first longitudinal, multicentre analysis of C. difficile prevalence among adult CF subjects. METHODOLOGY: Faecal samples were collected from adults with CF (selected based on confirmed Pseudomonas aeruginosa pulmonary colonisation) from Ireland, UK and Belgium as part of the CFMATTERS clinical research trial (grant No...
January 11, 2021: Journal of Infection