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https://www.readbyqxmd.com/read/28351053/macular-edema-rationale-for-therapy
#1
Thomas J Wolfensberger
Macular edema represents the end-stage of multiple pathophysiological pathways in a multitude of ocular vascular, inflammatory, and other diseases. The rationale for clinical treatment of macular edema is based on the understanding and the inhibition of these pathophysiological mechanisms. When macular edema is caused by a generalized health problem such as diabetes, high blood pressure, or generalized inflammatory conditions, treatment of these generalized diseases can in many cases cure macular edema directly...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28350850/defective-bone-repair-in-mast-cell-deficient-cpa3cre-mice
#2
Jose Luis Ramirez-GarciaLuna, Daniel Chan, Robert Samberg, Mira Abou-Rjeili, Timothy H Wong, Ailian Li, Thorsten B Feyerabend, Hans-Reimer Rodewald, Janet E Henderson, Paul A Martineau
In the adult skeleton, cells of the immune system interact with those of the skeleton during all phases of bone repair to influence the outcome. Mast cells are immune cells best known for their pathologic role in allergy, and may be involved in chronic inflammatory and fibrotic disorders. Potential roles for mast cells in tissue homeostasis, vascularization and repair remain enigmatic. Previous studies in combined mast cell- and Kit-deficient KitW-sh/W-sh mice (KitW-sh) implicated mast cells in bone repair but KitW-sh mice suffer from additional Kit-dependent hematopoietic and non- hematopoietic deficiencies that could have confounded the outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28350668/regeneration-of-vascularized-corticocancellous-bone-and-diploic-space-using-muscle-derived-stem-cells-a-translational-biologic-alternative-for-healing-critical-bone-defects
#3
Denver Lough, Edward Swanson, Nikolai A Sopko, Christopher Madsen, Devin Miller, Howard Wang, Qiongyu Guo, Srinivas M Sursala, Anand R Kumar
BACKGROUND: Regeneration of functional bone substrate remains a priority in reconstructive surgery especially for patients suffering from complex skeletal defects. Efforts to develop implantable osteoinductive constructs and novel osteoconductive materials remain at the forefront of industry forces and product line development. Despite advancement in clinical practice and bone biology, cancellous autograft remains the gold standard for procedures requiring osteogenic mechanisms of healing...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28345758/biodegradable-gelatin-beta-tricalcium-phosphate-sponges-incorporating-recombinant-human-fibroblast-growth-factor-2-for-treatment-of-recession-type-defects-a-split-mouth-study-in-dogs
#4
A Shujaa Addin, T Akizuki, S Hoshi, T Matsuura, T Ikawa, S Fukuba, M Matsui, Y Tabata, Y Izumi
BACKGROUND AND OBJECTIVE: Tissue engineering by using recombinant human (rh) growth factor technology may offer a promising therapeutic approach for treatment of gingival recession. Fibroblast growth factor-2 (FGF-2) has shown the ability to promote periodontal regeneration. Gelatin/beta-tricalcium phosphate (gelatin/β-TCP) sponges have been developed to control the release of growth factors. The present study evaluated the periodontal regenerative efficacy of rhFGF-2 by comparing gelatin/β-TCP sponges incorporated with rhFGF-2 to the scaffolds alone in artificially created recession-type defects in dogs...
March 27, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28345735/-supratentorial-cavernous-malformations-in-an-argentinian-institution-experience-with-surgical-treatment
#5
G E Vergara, A Cervio, M Farez, R Mormandi, S Condomi-Alcorta, J Salvat
INTRODUCTION: Cavernous malformations are vascular malformations of the central nervous system formed by a group of capillaries not covered by pia mater and communicated to the vascular system at very low pressure with very slow flow. Surgery or radiosurgery are the treatment modalities. AIMS: To analyze our results after surgical treatment of supratentorial cavernous malformations, reviewing clinical presentation, surgical indications and postoperative complications...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28345682/-occupational-exposure-in-orthopedic-procedures-under-fluoroscopic-control
#6
Edyta Owsiak, Renata Kopeć, Maciej Budzanowski, Maria A Staniszewska
BACKGROUND: In interventional radiology the highest radiation doses are usually recorded for both the medical staff and the patients. Interventional procedures with X-rays are implemented in a number of medical specializations. This paper concerns the exposure of interventional teams performing orthopedic procedures under X-rays control. MATERIAL AND METHODS: Doses for interventional teams were measured in the 3 Łódź hospitals. Thermoluminescent dosemeters were applied to measure the following dose equivalents: Hp(3) for eye lens, Hp(0...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345517/ptosis-and-vertical-diplopia-after-ligation-of-ethmoidal-arteries
#7
A Kahn, L Laccourreye, H D Fournier, C Brecheteau
The treatment of epistaxis is well codified, ligation of the ethmoidal arteries being the last resort. We report the case of a 25-year-old pregnant patient, who has had a ligation of the anterior and posterior ethmoidal arteries after a persistent epistaxis. Postoperatively, she presented a complete ptosis and an impaired eye elevation without any visual acuity disorders, evoking a lesion of the upper branch of the common oculomotor nerve (third cranial nerve). The patient totally recovered after 3 months...
February 21, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28344829/systemic-angiopoietin-1-2-dysregulation-following-cardiopulmonary-bypass-in-adults
#8
Emmanuel Charbonney, Elizabeth Wilcox, Yuexin Shan, Pablo Perez d'Empaire, Abhijit Duggal, Gordon D Rubenfeld, Conrad Liles, Claudia Dos Santos
AIM: Vascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes. METHODS: Observational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass. RESULTS: Ang-2 levels increased immediately postop whereas Ang-1 levels decreased over time...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28344561/fetal-growth-restriction-induces-heterogeneous-effects-on-vascular-biomechanical-and-functional-properties-in-guinea-pigs-cavia-porcellus
#9
Daniel Cañas, Emilio A Herrera, Claudio García-Herrera, Diego Celentano, Bernardo J Krause
Aim: Fetal growth restriction (FGR) is associated with a variety of cardiometabolic diseases in adulthood which could involve remodeling processes of the vascular walls that could start in the fetal period. However, there is no consensus whether this remodeling affects in a similar way the whole vascular system. We aimed to determine the effects of FGR on the vasoactive and biomechanical properties of umbilical and systemic vessels in fetal guinea pigs. Methods: FGR was induced by implanting ameroid occluders at mid-gestation in uterine arteries of pregnant guinea pigs, whilst the control group was exposed to simulated surgery...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28344523/scaphoid-nonunion-with-poor-prognostic-factors-the-role-of-the-free-medial-femoral-condyle-vascularized-bone-graft
#10
Tahseen Chaudhry, Lauren Uppal, Dominic Power, Michael Craigen, Simon Tan
Background: To report on the results of free medial femoral condyle (MFC) vascularized bone graft for scaphoid nonunions with 1 or more poor prognostic factors. Methods: We have used the free MFC vascularized bone graft for scaphoid nonunions that have 1 or more factors associated with a poor prognosis. These were, a delay in presentation of over 5 years, a proximal pole nonunion, the presence of avascular necrosis (AVN), or previous nonunion surgery. We used this technique on 20 patients over a 4.5-year period...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28344026/the-impact-of-various-scaffold-components-on-vascularized-bone-constructs
#11
Ahmad Eweida, Matthias Schulte, Oliver Frisch, Ulrich Kneser, Leila Harhaus
Bone tissue engineering is gaining more interest in the field of craniofacial surgery where continuous efforts are being made to improve the outcomes via modulation of the scaffold components. In an in vitro three dimensional (3D) culture, the effect of bone morphogenic protein 2 (BMP2, 60 μg/ml) and the effect of different cell seeding densities (0.25, 0.5, and 1 × 104) of rat mesenchymal stem cells seeded on nanocrystalline hydroxyapatite in silica gel matrix (Nanobone(®)) on the cell viability and differentiation were studied...
February 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28343682/fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-iii-goal-directed-hemodynamic-therapy-rationale-for-maintaining-vascular-tone-and-contractility
#12
J Ripollés-Melchor, D Chappell, H D Aya, Á Espinosa, M G Mhyten, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
March 24, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28342638/-rationale-and-complications-of-the-anterior-lateral-extrapleural-retroperitoneal-approach-for-unstable-thoracolumbar-fractures-experience-in-86-consecutive-patients
#13
Pedro David Delgado-López, Antonio Rodríguez-Salazar, Vicente Martín-Velasco, Javier Martín-Alonso, José Manuel Castilla-Díez, Ana Galacho-Harriero, Elena Araús-Galdós
OBJECTIVES: To describe the rationale, pros and cons, and complications of the anterior-lateral extrapleural retroperitoneal approach for unstable (TLICS>4) thoracolumbar fractures. PATIENTS AND METHODS: Clinical and radiological data and outcomes from a cohort treated surgically via said approach were retrospectively reviewed. All patients were operated on exclusively by 5 neurosurgeons trained in spine surgery. RESULTS: Between June 1999 and December 2015, 86 patients underwent surgery (median age 42years, most common level: L1)...
March 22, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28342287/longitudinal-evaluation-of-perfusion-changes-in-acute-and-chronic-renal-allograft-rejection-using-arterial-spin-labeling-in-translational-mouse-models
#14
Katja Hueper, Martina Schmidbauer, Anja Thorenz, Jan H Bräsen, Marcel Gutberlet, Michael Mengel, Dagmar Hartung, Rongjun Chen, Martin Meier, Hermann Haller, Frank Wacker, Song Rong, Faikah Gueler
PURPOSE: To examine the longitudinal changes of renal perfusion due to acute and chronic renal allograft rejection by using arterial spin labeling (ASL) MRI in translational mouse models of isogenic and allogenic kidney transplantation (ktx). MATERIALS AND METHODS: Acute rejection was induced by allogenic ktx of C57BL/6 (B6)-kidney grafts to BALB/c-recipients with prolonged cold ischemia (CIT) of 60 minutes (n = 13). To induce chronic rejection BALB/c-kidneys were transplanted into B6-recipients with short CIT of 30 minutes (n = 22)...
March 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28341606/safety-and-efficacy-of-sequential-intracorneal-ring-segment-implantation-and-crosslinking-in-pediatric-keratoconus
#15
Youssef Abdelmassih, Sylvain El-Khoury, Ali Dirani, Rafic Antonios, Ali Fadlallah, Carole G Cherfan, Elias Chelala, Elias F Jarade
PURPOSE: To evaluate the safety and visual outcome of intracorneal ring segment (ICRS) implantation followed by crosslinking in pediatric keratoconus patients. DESIGN: Retrospective interventional case series METHODS: This retrospective study included pediatric patients (≤14 years) with keratoconus and poor corrected distance visual acuity (CDVA) that underwent ICRS implantation and crosslinking (CXL). ICRS were inserted under topical anesthesia after creating a corneal tunnel with an Intralase femtosecond laser...
March 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28341505/secondary-aortoenteric-erosion-followed-by-recurrent-lower-extremity-abscesses
#16
Shigeshi Ono, Yoshitomo Samejima, Susumu Watada, Toshihiro Kakefuda
A secondary aortoenteric fistula (SAEF) is a relatively rare complication of aortoiliac reconstructive surgery, often involving relatively fixed duodenal 3(rd) portion and a vascular anastomosis. We observed a 52-year-old man with a recurrent right lower leg abscess following the erosion between ipsilateral bifurcated prosthetic graft limb and non-fixed jejunum. In situ graft-sparing surgical treatment with aggressive debridement was successfully performed. A SAEF may occur even at a non-vascular anastomosis site, or in non-fixed small bowel, and may become a source of a septic embolus...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28341500/effect-of-2-chlorhexidine-gluconate-impregnated-cloth-on-surgical-site-infections-in-vascular-surgery
#17
John Bak, Jason Le, Toshio Takayama, Angela Gibson, Sara Zerbel, Nasia Safdar, Jon Matsumura
OBJECTIVE: Surgical site infections (SSI) are a significant burden to patients and healthcare systems. This retrospective study evaluates the observed rates of SSI after our institution implemented chlorhexidine gluconate-impregnated (CHG) cloth as a preoperative antiseptic preparation in elective vascular surgery. METHODS: Between March 2011 and January 2012, we reviewed 250 patients who underwent elective vascular surgery who used the CHG cloth preoperatively...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28340844/anatomic-diversity-encountered-during-laparoscopic-hand-assisted-transperitoneal-donor-nephrectomy-a-case-report-of-complete-caval-duplication
#18
S L Kirecci, M Demir, M Ilgi, M Battal, A I Dokucu, A Unsal
INTRODUCTION: Laparoscopic donor nephrectomy is widely used to retrieve a kidney for transplantation. Preoperative evaluation of the donor is of crucial importance to the recipient. In particular, vascular anatomy should be assessed with the help of modern imaging modalities. We present a hand-assisted laparoscopic nephrectomy of a kidney donor with a complete duplex vena cava. CASE REPORT: A 40-year-old male patient was admitted to our clinic as a kidney donor for his 20-year-old son...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28340834/hepatic-artery-reconstruction-with-autologous-inferior-mesenteric-artery-graft-in-living-donor-liver-transplant-recipients
#19
M Özbilgin, T Ünek, T Egeli, C Ağalar, S Ozkardesler, F Obuz, H Ellidokuz, S Karademir, I Astarcıoğlu
INTRODUCTION: In living donor liver transplantation (LDLT), hepatic arterial continuity is crucial to avoid biliary leakage, biliary stricture, cholangitis, and graft and patient loss. Sometimes there exist factors making anastomosis difficult or even impossible. In these cases, a vascular graft may be needed to bridge the two arteries for revascularization. METHOD: Medical records of 297 patients who underwent LDLT between June 2000 and July 2016 at the Hepatopancreatobiliary Surgery and Liver Transplantation Unit of Dokuz Eylul University Hospital were reviewed retrospectively...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28340695/long-term-follow-up-after-autologous-adipose-derived-stromal-vascular-fraction-injection-into-fingers-in-systemic-sclerosis-patients
#20
A Daumas, J Magalon, E Jouve, R Truillet, D Casanova, L Giraudo, J Veran, A Benyamine, F Dignat-George, G Magalon, F Sabatier, B Granel
INTRODUCTION: Hand involvement confers a substantial handicap in work and daily activities in patients with Systemic sclerosis (SSc). Autologous adipose-derived stromal vascular fraction is as an easily accessible source of cells with regenerative effects. We previously performed a phase I open-label clinical trial (NTC01813279) assessing the safety of subcutaneous injection of autologous adipose-derived stromal vascular fraction. Six and 12-month data have been reported. As patients were followed in our medical centre, we report their longer-term outcome beyond the end of the trial...
January 2017: Current Research in Translational Medicine
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