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Vascular surgery

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https://www.readbyqxmd.com/read/30244410/s100p-and-ezrin-promote-trans-endothelial-migration-of-triple-negative-breast-cancer-cells
#1
Kyoko Kikuchi, Keely May McNamara, Yasuhiro Miki, Erina Iwabuchi, Ayako Kanai, Minoru Miyashita, Takanori Ishida, Hironobu Sasano
PURPOSE: Triple negative breast cancer (TNBC) patients generally have an adverse clinical outcome because their tumors often recur and metastasize to distant sites in the first 3 years after surgery. Therefore, it has become pivotal to identify potential factors associated with metastasis. Here, we focused on the effects of S100P and Ezrin on the trans-endothelial migration (TEM) of TNBC cells, as they have both been suggested to play a role in this process in other malignancies. METHODS: The expression of S100P and Ezrin was examined by immunohistochemistry in 58 primary TNBC samples...
September 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/30244240/common-rodent-flap-models-in-experimental-surgery
#2
REVIEW
Daniel Schmauss, Andrea Weinzierl, Verena Schmauss, Yves Harder
BACKGROUND: Flap procedures are widely used in clinical reconstructive surgery. Since ische-mia-associated complications, e.g., wound breakdown or tissue necrosis, are still a great challenge in flap surgery, experimental flap models are widely used to study flap physiology and to evaluate treatment strategies to prevent these complications. SUMMARY: Since rodents in general, and mice and rats in particular, are widely used in experimental flap models, we give an overview of the most common flap models in rodents, including the cremaster flap, the osteomyocutaneous flap, the McFarlane flap, the ear flap, and the dorsal skinfold chamber...
September 21, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30243897/expression-of-epidermal-growth-factor-receptor-egfr-in-colorectal-cancer-an-immunohistochemical-study
#3
Ehsen Ben Brahim, Imen Ayari, Raja Jouini, Salsabil Atafi, Wafa Koubaa, Hela Elloumi, Aschraf Chadli
BACKGROUND AND STUDY AIM: The epidermal growth factor receptor (EGFR) plays an important role in tumourigenesis and tumour progression of colorectal cancer (CRC) and leads to the activation of intracellular signaling pathways. The use of anti-EGFR-targeted therapy has increased for patients with metastatic CRC. Today, the clinical utility of immunohistochemistry has remained somewhat inconclusive. It is based on EGFR screening methods using paraffin-embedded tumour specimen to select patients eligible for treatment...
September 20, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30243706/unplanned-reoperations-in-oral-and-maxillofacial-surgery
#4
Zhifang Zhao, Jing Hao, Qian He, Runzhi Deng
PURPOSE: The purpose of this study was to determine the incidence of and reasons for unplanned reoperations in oral and maxillofacial surgery. MATERIALS AND METHODS: During a 4-year period, a total of 169 patients undergoing reoperations were encountered. The clinical characteristics and causes were reviewed. RESULTS: There were 11,151 patients who underwent surgery, and the incidence of unplanned reoperations was 1.52%. The male-to-female ratio was 2...
August 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30243559/ipsilateral-ureteroureterostomy-does-function-of-the-obstructed-moiety-matter
#5
T Kawal, A K Srinivasan, R Talwar, D I Chu, C Long, D Weiss, J Van Batavia, T F Kolon, A R Shukla
PURPOSE: Upper pole nephrectomy has been the traditional surgical management of children with poorly functioning upper pole moieties in duplex renal collecting systems having ureteral ectopia and ureterocele. However, ablative surgery confers a risk of functional loss to the remnant moiety due to vasospasm or vascular injury. It was hypothesized that ipsilateral ureteroureterostomy (IUU) is a safe and feasible approach for the management of these patients and that residual function in the obstructed upper pole does not affect surgical outcomes...
August 20, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30243294/effects-of-propofol-remifentanil-based-total-intravenous-anesthesia-versus-sevoflurane-based-inhalational-anesthesia-on-the-release-of-vegf-c-and-tgf-%C3%AE-and-prognosis-after-breast-cancer-surgery-a-prospective-randomized-and-controlled-study
#6
Tao Yan, Guo-Hua Zhang, Bao-Na Wang, Li Sun, Hui Zheng
BACKGROUND: Vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) have been involved in tumor growth and metastasis. Sevoflurane may promote angiogenesis, whereas propofol can present an anti-angiogenic effect. In this study, we compared the effects of propofol/remifentanil-based total intravenous anesthesia (TIVA) and sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β, as well as recurrence- free survival (RFS) rates in the patients undergoing breast cancer surgery...
September 22, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30242025/microrna-21-and-venous-neointimal-hyperplasia-of-dialysis-vascular-access
#7
Chih-Cheng Wu, Li-Jing Chen, Mu-Yang Hsieh, Chien-Ming Lo, Ming-Hsien Lin, Hsiao-En Tsai, Hsiang-Lin Song, Jeng-Jiann Chiu
BACKGROUND AND OBJECTIVES: There is increasing evidence that microRNAs (miRNAs) play crucial roles in the regulation of neointima formation. However, the translational evidence of the role of miRNAs in dialysis vascular access is limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: miRNA expression in tissues was assessed by using venous tissues harvested from ten patients on dialysis who received revision or removal surgery, and ten patients who were predialysis and received creation surgery of arteriovenous fistulas served as controls...
September 21, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/30241716/vascular-graft-infections-an-update
#8
REVIEW
Amal Gharamti, Zeina A Kanafani
Vascular graft infection is a devastating complication of vascular reconstructive surgery. The infection can occur early in the postoperative period and is largely due to intraoperative contamination or by contiguous extension from a nearby infection. It can also occur years after implantation. Staphylococci remain the most common organisms and biofilm production makes eradication difficult. Factors commonly reported to predispose to vascular graft infection are periodontal disease, nasal colonization with Staphylococcus aureus, bacteremia, certain graft characteristics, diabetes mellitus, postoperative hyperglycemia, location of the incision, wound infection, and emergency procedure...
September 18, 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/30240858/the-usefulness-of-dual-volume-visualization-three-dimensional-digital-subtraction-angiography-and-cross-sectional-imaging-for-surgical-planning-in-treating-intracranial-meningiomas-a-case-series-and-technical-report
#9
Young Il Kim, Dong Hoon Lee, Chul Bum Cho, Seung Ho Yang, Il Sup Kim, Jae Taek Hong, Jae Hoon Sung, Sin Soo Jeun
OBJECTIVE: In pre-surgical planning for intracranial meningiomas, the relationship between tumors and adjacent vasculature must be identified. The purpose of this study was to evaluate the usefulness of three-dimensional digital subtraction angiography (3D-DSA) with dual volume visualization (DVV). METHODS: Between Feb. 2013 and April 2016, 26 patients with intracranial meningioma enrolled in this study. Two or 3 days before surgery, 3D-DSA with DVV was performed for pre-surgical planning...
September 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30239778/live-birth-rate-and-obstetric-complications-following-the-hysteroscopic-management-of-intrauterine-adhesions-including-asherman-syndrome
#10
Rebecca Deans, Thierry Vancaillie, William Ledger, Jinzhu Liu, Jason A Abbott
STUDY QUESTION: What are the live birth rate and risks of obstetric complications following the surgical management of intrauterine adhesions (IUA) such as Asherman syndrome (AS)? SUMMARY ANSWER: The live birth rate is 63.7%, and obstetric complications including placentation issues, prematurity and postpartum hysterectomy require that pregnancies in women after treatment for IUA should be considered moderate to high risk. WHAT IS KNOWN ALREADY: Studies reviewing short-term surgical, menstrual and fertility outcomes following hysteroscopic management are reassuring, with success correlated to the severity of IUA...
September 18, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30239497/identifying-predictors-of-time-to-soft-tissue-reconstruction-following-open-tibia-fractures
#11
Ronnie L Shammas, Lily R Mundy, Tracy Truong, Jeremy M Weber, A Jordan Grier, Eugenia H Cho, Sarah B Peskoe, Mark J Gage, Scott T Hollenbeck
INTRODUCTION: Controversy remains regarding the optimal timing of soft tissue coverage following severe lower extremity trauma. This study identifies nationwide practice patterns and factors associated with discrepancies in time to first flap surgery following open tibia fractures. METHODS: A retrospective analysis was performed on the National Trauma Databank from 2008-2015 to identify patients who presented with an open tibia fracture and underwent subsequent flap reconstruction...
September 4, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30239097/mycobacterium-ulcerans-disease-management-in-australian-patients-the-re-emergence-of-surgery-as-an-important-treatment-modality
#12
REVIEW
Daniel P O'Brien, Peter Callan, N Deborah Friedman, Eugene Athan, Andrew Hughes, Anthony McDonald
With the demonstration of the effectiveness of antibiotic treatment, the management of Mycobacterium ulcerans disease has changed from a predominantly surgically to a predominantly medically treated disease. However, research among Australian patients has revealed that antibiotic treatment alone is associated with prolonged wound healing times, high rates of treatment toxicity, and the potential for significant tissue destruction associated with severe paradoxical reactions. We present the current state of M...
September 21, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30238985/stromal-vascular-fraction-cells-plus-sustained-release-vegf-ang-1-plga-microspheres-improve-fat-graft-survival-in-mice
#13
Yucang He, Xiaofang Yu, Zhuojie Chen, Liqun Li
Autologous fat transplantation is increasingly applied in plastic and reconstructive surgery. Stromal vascular fraction cells (SVFs) combined with angiogenic factors, such as VEGF (vascular endothelial growth factor A) and Ang-1 (angiogenin-1), can improve angiogenesis, which is a critical factor for graft survival. However, direct transplant with such a mixture is insufficient owing to the short half-life of angiogenic factors. In this study, we evaluated whether a double sustained release system of VEGF/ANG-1-PLGA (poly (lactic-co-glycolic acid)) microspheres plus SVFs can improve angiogenesis and graft survival after autologous fat transplantation...
September 21, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30238444/a-randomized-trial-of-early-endovenous-ablation-in-venous-ulceration-a-critical-appraisal
#14
K T Weiß, F Zeman, S Schreml
Manjit S. Gohel et al. (N Engl J Med 2018; 378: 2105-2114) aimed to compare early endovenous ablation vs. deferred endovenous ablation of superficial venous reflux regarding time to healing of venous leg ulcers, rate of healing at 24 weeks, recurrence rate, ulcer-free time, and health-related quality of life. SETTING AND DESIGN: This multicentre, parallel-group (ratio 1:1), randomized controlled trial was conducted in a vascular surgery department setting at 20 participating centres across the United Kingdom...
September 20, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30238334/preoperative-portal-vein-embolization-alone-with-biliary-drainage-compared-to-a-combination-of-simultaneous-portal-vein-right-hepatic-vein-embolization-and-biliary-drainage-in-klatskin-tumor
#15
Arnaud Hocquelet, Charalampos Sotiriadis, Rafael Duran, Boris Guiu, Takamune Yamaguchi, Nermin Halkic, Emmanuel Melloul, Nicolas Demartines, Alban Denys
PURPOSE: To compare estimated future remnant liver (FRL) growth following portal vein embolization or liver venous deprivation (LVD) (combined PVE and right hepatic vein embolization), before surgery for a Klatskin tumor in patients who receive intraoperative biliary drainage or before venous interventional radiology. MATERIAL AND METHOD: Six patients underwent LVD and six underwent PVE alone before hepatectomy for a Klatskin tumor. Before embolization, the FRL ratio, prothrombin time and bilirubin levels were similar in both groups...
September 20, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/30237988/the-lethal-twist-a-story-of-unspoken-pain-small-intestinal-volvulus-in-cerebral-palsy
#16
Kritika Krishnamurthy, Siba El Hussein, Yumna Omarzai
Small intestinal volvulus (SBV) is the abnormal twisting of bowel around the axis of its mesentery, leading to obstruction and vascular compromise, resulting in bowel ischemia and necrosis which are life-threatening. Risk factors include malformation, malrotation, and adhesions. Its rare incidence and vague clinical presentation make it a difficult diagnosis, more so in a nonverbal patient who cannot express his pain, which is the first and most prominent symptom. Studies suggest an increased frequency of intestinal obstruction in cerebral palsy patients...
July 2018: Autopsy & case reports
https://www.readbyqxmd.com/read/30237668/treatment-of-aortic-aneurysms-registered-in-swedvasc-development-reflected-in-a-national-vascular-registry-with-an-almost-100-coverage
#17
REVIEW
D Bergqvist, K Mani, T Troëng, A Wanhainen
Swedvasc is a registry for vascular surgical procedures, both open and endovascular. It was started in 1987 and since 1994 the whole population of Sweden is covered, at present around 10 million inhabitants. In a recent external validation, it was found to be highly accurate with abdominal aortic aneurysm surgery correctly reported in >96%. In this paper various factors explaining the almost 100% coverage are discussed, one important being that the registry has been developed and maintained within the profession of vascular surgery and not dictated by authorities...
2018: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/30237563/promoted-angiogenesis-and-osteogenesis-by-dexamethasone-loaded-calcium-phosphate-nanoparticles-collagen-composite-scaffolds-with-microgroove-networks
#18
Ying Chen, Shangwu Chen, Naoki Kawazoe, Guoping Chen
Reconstruction of large bone defects remains a clinical challenge because current approaches involving surgery and bone grafting often do not yield satisfactory outcomes. For artificial bone substitutes, angiogenesis plays a pivotal role to achieve the final success of newly regenerated bone. In this study, dexamethasone-loaded biphasic calcium phosphate nanoparticles/collagen composite scaffolds with several types of concave microgrooves were prepared for simultaneous promotion of angiogenesis and osteogenesis...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30236876/clinical-results-and-quality-of-life-after-reconstruction-following-sacrectomy-for-primary-bone-malignancy
#19
Juha Kiiski, Hannu O Kuokkanen, Minna Kääriäinen, Ilkka S Kaartinen, Toni-Karri Pakarinen, Minna K Laitinen
BACKGROUND: Sacrectomy is a rare and demanding surgical procedure that results in major soft tissue defects and spinopelvic discontinuity. No consensus is available on the optimal reconstruction algorithm. Therefore, the present study evaluated the results of sacrectomy reconstruction and its impact on patients' quality of life (QOL). METHODS: A retrospective chart review was conducted for 21 patients who underwent sacrectomy for a primary bone tumour. Patients were divided into groups based on the timing of reconstruction as follows: no reconstruction, immediate reconstruction or delayed reconstruction...
August 24, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30236497/controversial-results-of-the-revised-cardiac-risk-index-in-elective-open-repair-of-abdominal-aortic-aneurysms-retrospective-analysis-on-a-continuous-series-of-899-cases
#20
Angela M R Ferrante, Umberto Moscato, Francesco Snider, Yamume Tshomba
BACKGROUND: Low reliability of Revised Cardiac Risk Index (RCRI) in predicting major cardiac events (MACE) among Vascular Surgery patients emerged in recent literature, suggesting procedure-specific risk evaluation - particularly in major surgery. METHODS-RESULTS: Comorbidities, perioperative variables, RCRI and MACE were retrospectively analyzed in a consecutive series of 899 elective open abdominal aortic aneurysm (AAA) repairs performed at our Institution. Possible MACE predictors were studied through univariate/multivariable analysis (logistic regression, MVRE) and stepwise-backward elimination/odds ratio (MVR-SBE/OR)...
September 10, 2018: International Journal of Cardiology
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