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https://www.readbyqxmd.com/read/29235993/raman-micro-spectroscopy-analysis-of-human-lens-epithelial-cells-exposed-to-a-low-dose-range-of-ionizing-radiation
#1
Christian Harry Allen, Achint Kumar, Sami Qutob, Balazs J Nyiri, Vinita Chauhan, Sangeeta Murugkar
Recent findings in populations exposed to ionizing radiation (IR) indicate dose-related lens opacification occurs at much lower doses (< 2Gy) than indicated in radiation protection guidelines. As a result, research efforts are now being directed towards identifying early predictors of lens degeneration resulting in cataractogenesis. In this study, Raman micro-spectroscopy was used to investigate the effects of varying doses of radiation, ranging from 0.01 Gy to 5 Gy, on human lens epithelial (HLE) cells which were chemically fixed 24 hrs post-irradiation...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29235115/the-mechanistic-basis-of-demographic-allee-effects-the-search-for-mates
#2
Anna Kuparinen
In Focus: Berec, L., Kremer, A.M., Bernhauverova, V., & Drake, J.M. (2017). Density-dependent selection on mate-finding Allee effects. Journal of Animal Ecology, 87, 24-35. https://doi.org/10.1111/1365-2656.12662 In Focus: Shaw, A.K., Kokko, H., & Neubert, M.G. (2017). Details of mate finding drive dynamics of sex structured invasions. Journal of Animal Ecology, 87, 36-46. https://doi.org/10.1111/1365-2656.12658 Lowered population growth ability at low abundances is called the demographic Allee effect. The difficulty of finding mates in a sparse population is the best documented pathway through which a demographic Allee effect might arise...
January 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29235072/a-bayesian-approach-to-estimating-variance-components-within-a-multivariate-generalizability-theory-framework
#3
Zhehan Jiang, William Skorupski
In many behavioral research areas, multivariate generalizability theory (mG theory) has been typically used to investigate the reliability of certain multidimensional assessments. However, traditional mG-theory estimation-namely, using frequentist approaches-has limits, leading researchers to fail to take full advantage of the information that mG theory can offer regarding the reliability of measurements. Alternatively, Bayesian methods provide more information than frequentist approaches can offer. This article presents instructional guidelines on how to implement mG-theory analyses in a Bayesian framework; in particular, BUGS code is presented to fit commonly seen designs from mG theory, including single-facet designs, two-facet crossed designs, and two-facet nested designs...
December 12, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29234379/the-instrument-for-measuring-the-implementation-situation-of-traditional-chinese-medicine-guideline-evaluation-and-application
#4
Hui Li, Yangyang Wang, Yaolong Chen, Xiaoyun Wang, Chuanjian Lu, Jingwen Deng
Clinical practice guidelines play an important role in reducing the variations in clinical practices and improving the quality of care. To assess the real effect, measuring its implementation situation is needed. The implementation situation can be reflected by testing the consistency between the actual clinical practice and the guideline. We constructed an instrument to measure the implementation situation of Traditional Chinese Medicine (TCM) guideline through consistency testing. The main objectives of our study were to validate the instrument and evaluate the implementation situation of menopause syndrome guideline of TCM, using the data from the consistency test of comparing the medical records with the guideline...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233087/stroke-prevention-rehabilitation-intervention-trial-of-exercise-sprite-a-randomised-feasibility-study
#5
Neil Heron, Frank Kee, Jonathan Mant, Philip M Reilly, Margaret Cupples, Mark Tully, Michael Donnelly
BACKGROUND: The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to evaluate the feasibility of conducting a trial of an adapted home-based CR programme, 'The Healthy Brain Rehabilitation Manual', for patients following a TIA/minor stroke, participants' views on the intervention and, to identify the behaviour change techniques (BCTs) used...
December 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29229228/factors-influencing-norvancomycin-concentration-in-plasma-and-cerebrospinal-fluid-in-patients-after-craniotomy-and-dosing-guideline-a-population-approach
#6
Xingang Li, Yuanxing Wu, Shusen Sun, Qiang Wang, Zhigang Zhao
PURPOSE: Antibacterial spectrum and activity of norvancomycin are comparable with vancomycin, and it has been widely used in China. Norvancomycin can penetrate into the cerebrospinal fluid (CSF) through the damaged blood-brain barrier in patients after craniotomy. Because higher inter-individual variability was observed, we aimed to identify factors related to drug concentration to guide clinicians with norvancomycin dosing. METHODS: After craniotomy, patients with an indwelling catheter in the operational area/ventricle were intravenously administered norvancomycin...
December 8, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29228196/data-discovery-with-dats-exemplar-adoptions-and-lessons-learned
#7
Alejandra N Gonzalez-Beltran, John Campbell, Patrick Dunn, Diana Guijarro, Sanda Ionescu, Hyeoneui Kim, Jared Lyle, Jeffrey Wiser, Susanna-Assunta Sansone, Philippe Rocca-Serra
The DAta Tag Suite (DATS) is a model supporting dataset description, indexing, and discovery. It is available as an annotated serialization with schema.org, a vocabulary used by major search engines, thus making the datasets discoverable on the web. DATS underlies DataMed, the National Institutes of Health Big Data to Knowledge Data Discovery Index prototype, which aims to provide a "PubMed for datasets." The experience gained while indexing a heterogeneous range of >60 repositories in DataMed helped in evaluating DATS's entities, attributes, and scope...
December 8, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29227451/cartilage-conduction-hearing-aids-for-severe-conduction-hearing-loss
#8
Tadashi Nishimura, Hiroshi Hosoi, Osamu Saito, Ryota Shimokura, Toshiaki Yamanaka, Tadashi Kitahara
OBJECTIVE: To assess the benefits of a new type of hearing aid using cartilage conduction (CC) in patients with severe conduction hearing loss and evaluate its potential for practical use. STUDY DESIGN: Consecutive, prospective case series. PATIENTS: Forty-one subjects (21 with bilateral aural atresia; 15 with unilateral aural atresia; and 5 others) participated in this study. INTERVENTION: Fitting and gain adjustments of the CC hearing aids were performed to the ear(s) with conduction hearing loss...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29223004/towards-utilization-of-the-human-genome-and-microbiome-for-personalized-nutrition
#9
REVIEW
Stavros Bashiardes, Anastasia Godneva, Eran Elinav, Eran Segal
Generalized dietary and lifestyle guidelines have been formulated and published for decades now from a variety of relevant agencies in an attempt to guide people towards healthy choices. As the pandemic rise in metabolic diseases continues to increase, it has become clear that the one-fit-for-all diet approach does not work and that there is a significant variation in inter-individual responses to diet and lifestyle interventions. Recent technological advances have given an unprecedented insight into the sources of this variation, pointing towards our genome and microbiome as potentially and previously under-explored culprits contributing to individually unique dietary responses...
December 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29222045/challenges-in-risk-estimation-using-routinely-collected-clinical-data-the-example-of-estimating-cervical-cancer-risks-from-electronic-health-records
#10
Rebecca Landy, Li C Cheung, Mark Schiffman, Julia C Gage, Noorie Hyun, Nicolas Wentzensen, Walter K Kinney, Philip E Castle, Barbara Fetterman, Nancy E Poitras, Thomas Lorey, Peter D Sasieni, Hormuzd A Katki
Electronic health-records (EHR) are increasingly used by epidemiologists studying disease following surveillance testing to provide evidence for screening intervals and referral guidelines. Although cost-effective, undiagnosed prevalent disease and interval censoring (in which asymptomatic disease is only observed at the time of testing) raise substantial analytic issues when estimating risk that cannot be addressed using Kaplan-Meier methods. Based on our experience analysing EHR from cervical cancer screening, we previously proposed the logistic-Weibull model to address these issues...
December 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29221862/physical-activity-sedentary-time-tv-viewing-physical-fitness-and-cardiovascular-disease-risk-in-adolescents-the-helena-study
#11
Alan R Barker, Luis Gracia-Marco, Jonatan R Ruiz, Manuel J Castillo, Raquel Aparicio-Ugarriza, Marcela González-Gross, Anthony Kafatos, Odysseas Androutsos, Angela Polito, Dénes Molnar, Kurt Widhalm, Luis A Moreno
BACKGROUND: To examine the independent associations between physical activity (PA) intensities, sedentary time (ST), TV viewing, cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiovascular disease (CVD) risk in youth. METHODS: A cross-sectional study on 534 European adolescents (252 males, 282 females, 12.5-17.5years). Minutes per day of light (LPA), moderate (MPA) and vigorous (VPA) PA and total ST were measured using accelerometers. TV viewing time was measured using a questionnaire...
November 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29219090/systematic-review-of-the-relationships-between-physical-activity-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#12
Valerie Carson, Eun-Young Lee, Lyndel Hewitt, Cally Jennings, Stephen Hunter, Nicholas Kuzik, Jodie A Stearns, Stephanie Powley Unrau, Veronica J Poitras, Casey Gray, Kristi B Adamo, Ian Janssen, Anthony D Okely, John C Spence, Brian W Timmons, Margaret Sampson, Mark S Tremblay
BACKGROUND: Given the rapid development during the early years (0-4 years), an understanding of the health implications of physical activity is needed. The purpose of this systematic review was to examine the relationships between objectively and subjectively measured physical activity and health indicators in the early years. METHODS: Electronic databases were originally searched in April, 2016. Included studies needed to be peer-reviewed, written in English or French, and meet a priori study criteria...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29219071/systematic-review-of-the-relationships-between-combinations-of-movement-behaviours-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#13
Nicholas Kuzik, Veronica J Poitras, Mark S Tremblay, Eun-Young Lee, Stephen Hunter, Valerie Carson
BACKGROUND: A recent review highlighted important relationships between combinations of movement behaviours (i.e., sleep, sedentary behaviour, and physical activity) and health indicators among school-aged children and youth (aged 5-17 years). It is unclear whether similar relationships exist in younger children. Therefore, this review sought to examine the relationships between combinations of movement behaviours and health indicators in the early years (1.00 month to 4.99 years)...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29217780/from-transplant-to-novel-cellular-therapies-in-multiple-myeloma-emn-guidelines-and-future-perspectives
#14
Francesca Gay, Monika Engelhardt, Evangelos Terpos, Ralph Wäsch, Luisa Giaccone, Holger W Auner, Jo Caers, Martin Gramatzki, Niels van de Donk, Stefania Oliva, Elena Zamagni, Laurent Garderet, Christian Straka, Roman Hajek, Heinz Ludwig, Hermann Einsele, Meletios Dimopoulos, Mario Boccadoro, Nicolaus Kröger, Michele Cavo, Hartmut Goldschmidt, Benedetto Bruno, Pieter Sonneveld
Survival of myeloma patients has greatly improved with the use of autologous stem cell transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. Compared to bortezomib- and lenalidomide-based regimens alone, the addition of high-dose melphalan followed by autologous transplantation significantly improves progression-free survival; although an overall survival benefit was not observed in all trials. Moreover, follow-up of recent trials is still too short to show any difference in survival...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29214863/impact-of-a-weight-management-intervention-on-eating-competence-importance-of-measurement-interval-in-protocol-design
#15
Barbara Lohse, Jodi Stotts Krall, Tricia Psota, Penny Kris-Etherton
PURPOSE: To examine changes in eating competence (EC) in 12-month weight loss intervention. DESIGN: Randomized, parallel-arm with weight loss phase (baseline to month 4) and weight-maintenance phase (months 4-12). SETTING: Face-to-face in University classrooms, supervised and self-directed fitness sessions at University fitness center, and home. PARTICIPANTS: Premenopausal, mostly college-educated Pennsylvania women, body mass index >25 (n = 101)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214577/patient-empowerment-and-involvement-in-research
#16
Lilisbeth Perestelo-Pérez, Amado Rivero-Santana, Analia Abt-Sacks, Ana Toledo-Chavarri, Noe Brito, Yolanda Álvarez-Pérez, Nerea González-Hernández, Pedro Serrano-Aguilar
Patients with rare diseases often face difficulties in clinical care due to the low prevalence of their diseases and the resulting healthcare professionals' lack of expertise. Valid and standardized guidelines for clinical management are also lacking due to the scarcity of research and the variability of the clinical expressivity within each disease. In addition, in cases of rare diseases, the patient and health professional relationship may not fit with the traditional assumptions of medical care. Although the communication process between patients and healthcare professionals shares most of the general features of the standard patient-health professional interaction, rare diseases may be burdened with additional issues...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29210001/high-intensity-exercise-interventions-in-cancer-survivors-a-systematic-review-exploring-the-impact-on-health-outcomes
#17
REVIEW
Kellie Toohey, Kate Pumpa, Andrew McKune, Julie Cooke, Stuart Semple
PURPOSE: There is an increasing body of evidence underpinning high-intensity exercise as an effective and time-efficient intervention for improving health in cancer survivors. The aim of this study was to, (1) evaluate the efficacy and (2) the safety of high-intensity exercise interventions in improving selected health outcomes in cancer survivors. METHODS: Design Systematic review. Data sources Google Scholar and EBSCO, CINAHL Plus, Computers and Applied Sciences Complete, Health Source-Consumer Edition, Health Source: Nursing/Academic Edition, MEDLINE, Web of Science and SPORTDiscuss from inception up until August 2017...
December 5, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29205757/enhancing-metabolic-monitoring-for-children-and-adolescents-using-second-generation-antipsychotics
#18
Mary Coughlin, Catherine L Goldie, Deborah Tregunno, Joan Tranmer, Marina Kanellos-Sutton, Sarosh Khalid-Khan
The prevalence of children and adolescents using second-generation antipsychotics (SGAs) has increased significantly in recent years. In this population, SGAs are used to treat mood and behavioural disorders although considered 'off-label' or not approved for these indications. Metabolic monitoring is the systematic physical health assessment of antipsychotic users utilized to detect cardiovascular and endocrine side effects and prevent adverse events such as weight gain, hyperglycaemia, hyperlipidemia, and arrhythmias...
December 4, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29205436/validation-of-the-pain-resilience-scale-in-chinese-speaking-patients-with-tmd-pain
#19
Songlin He, Jinhua Wang, Ping Ji
To validate of the Pain Resilience Scale (PRS) for use in Chinese patients with temporomandibular disorders (TMD) pain. According to international guidelines, the original PRS was first translated and cross-culturally adapted to formulate the Chinese version of PRS (PRS-C). A total of 152 patients with TMD pain were recruited to complete series of questionnaires. Reliability of the PRS-C was investigated using internal consistency and test-retest reliability. Validity of the PRS-C was calculated using cross-cultural validity and convergent validity...
December 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29202919/stakeholders-guidance-document-for-consumer-analytical-devices-with-a-focus-on-gluten-and-food-allergens
#20
Bert Popping, Laura Allred, François Bourdichon, Kurt Brunner, Carmen Diaz-Amigo, Patricia Galan-Malo, Markus Lacorn, Jennifer North, Salvatore Parisi, Adrian Rogers, Jennifer Sealy-Voyksner, Tricia Thompson, Jupiter Yeung
Until recently, analytical tests for food were performed primarily in laboratories, but technical developmentsnow enable consumers to use devices to test their food at home or when dining out. Current consumer devices for food can determine nutritional values, freshness, and, most recently, the presence of food allergens and substances that cause food intolerances. The demand for such products is driven by an increase in the incidence of food allergies, as well as consumer desire for more information about what is in their food...
December 5, 2017: Journal of AOAC International
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