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Gurulingappa Hallur, Buchi Reddy Purra, Suresh P Sulochana, Neeraj Kumar Saini, Prasanthi Daram, Mohd Zainuddin, Ramesh Mullangi
A sensitive, specific, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of apalutamide in mice plasma using apalutamide-d3 as an internal standard (I.S.). Sample preparation was accomplished through a simple protein precipitation process. Chromatography of apalutamide and the I.S. was achieved on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (20:80, v/v) delivered at a flow rate of 0.8 mL/min. LC-MS/MS was operated under the multiple reaction-monitoring mode (MRM) using the electrospray ionization technique in positive ion mode and the transitions of m/z 478 → 450 and m/z 481 → 453 were used to measure the derivative of apalutamide and the I...
February 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
Louis F McIntyre
A considerable body of literature with high-level evidence has been published in the past 15 years calling into question the value of arthroscopic surgery in treating osteoarthritis of the knee (OAK). This, plus recent guidelines advising against the use of conservative treatments such as hyaluronic viscosupplementation, threatens to limit patient access to treatment for a chronic disease state with no known cure. The disease burden of OAK is considerable and represents one of the largest health care dollar expenditures in the United States and the world...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanner
MS Binding Assays represent a label free alternative to radioligand binding assays. In this study, we present an LC-ESI-MS/MS method for the quantification of (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol ((R,R)-D-84, (R,R)-1), (S,S)-reboxetine ((S,S)-2), and (S)-citalopram ((S)-3) employed as highly selective nonlabelled reporter ligands in MS Binding Assays addressing the dopamine (DAT, (R,R)-D-84), the norepinephrine (NET, (S,S)-reboxetine), and the serotonin transporter (SERT, (S)-citalopram), respectively...
March 3, 2018: Biomedical Chromatography: BMC
Mamdouh R Rezk, Kamal A Badr
A robust, rapid and sensitive UPLC-MS/MS method has been developed, optimized and validated for determination of amlodipine (AML) and atorvastatin (ATO) in human plasma using eplerenone as an internal standard (IS). Multiple-reaction monitoring in positive electrospray ionization mode was utilized in Xevo TQD LC-MS/MS. Double extraction was used in sample preparation using diethyl ether and ethyl acetate. The prepared samples were analyzed using Acquity UPLC BEH C18 (50 x 2.1 mm, 1.7 μm) column. Ammonium formate and acetonitrile, pumped isocraticaly at a flow rate of 0...
March 2, 2018: Biomedical Chromatography: BMC
Pau Herrero, Jorge Bondia, Marga Giménez, Nick Oliver, Pantelis Georgiou
BACKGROUND: People with insulin-dependent diabetes rely on an intensified insulin regimen. Despite several guidelines, they are usually impractical and fall short in achieving optimal glycemic outcomes. In this work, a novel technique for automatic adaptation of the basal insulin profile of people with diabetes on sensor-augmented pump therapy is presented. METHODS: The presented technique is based on a run-to-run control law that overcomes some of the limitations of previously proposed methods...
March 2018: Journal of Diabetes Science and Technology
Eva Louie, Vicki Giannopoulos, Andrew Baillie, Gabriela Uribe, Simon Byrne, Mark Deady, Maree Teesson, Amanda Baker, Paul S Haber, Kirsten C Morley
Comorbid mental health and substance use problems are highly prevalent in substance use treatment settings and generally lead to poorer treatment outcomes. Pathways to Comorbidity Care (PCC) is a multi-modal training program developed to encourage an integrated service approach to improve clinicians' capacity to identify and manage comorbid substance use and mental health outcomes within public drug and alcohol treatment settings. In this paper we describe the concepts underlying the PCC Package and the use of Implementation Science to assess and overcome potential barriers, including clinicians' preferences, knowledge about best practice and professional culture...
February 28, 2018: Journal of Dual Diagnosis
Catrine Tudor-Locke, John M Schuna, Ho Han, Elroy J Aguiar, Sandra Larrivee, Daniel S Hsia, Scott W Ducharme, Tiago V Barreira, William D Johnson
BACKGROUND: Steps/day is widely utilized to estimate the total volume of ambulatory activity, but it does not directly reflect intensity, a central tenet of public health guidelines. Cadence (steps/min) represents an overlooked opportunity to describe the intensity of ambulatory activity. We sought to establish thresholds linking directly observed cadence with objectively measured intensity in 6-20 year olds. METHODS: One hundred twenty participants completed multiple 5-min bouts on a treadmill, from 13...
February 26, 2018: International Journal of Behavioral Nutrition and Physical Activity
Reem N El Gammal, Mohammed E A Hammouda, Dalia R El-Wasseef, Saadia M El-Ashry
A simple rapid and accurate micellar high performance liquid chromatographic method was improved and validated for the analysis of mixture containing gatifloxacin sesquihydrate (GTF) and prednisolone acetate (PRED) in their synthetic mixture and their combined preparation. The separation was achieved using a C18 column, micellar mobile phase consisted of 0.2 M sodium dodecyl sulfate, 12.5% n-propanol and 0.3% triethylamine in 0.02 M orthophosphoric acid at pH 7.0 at a flow rate of 1 ml/min with UV detection at 270 nm...
February 21, 2018: Journal of Chromatographic Science
Mohammad Mehdi Soltan Dallal, Sajjad Omidi, Masoumeh Douraghi, Mohammad Taghi Haghi Ashtiani, Mohammad Kazem Sharifi Yazdi, Arash Okazi
Introduction: Shigella spp. is a growing global health concern due to increasing multiple drug resistance, commonly resulting in therapeutic failure. Integrons are gene expression systems run by integrase genes. The aims of this study were detection of class I, II and III integrons and assessment of antimicrobial resistance in Shigella spp. isolated from acute pediatric diarrhea patients. Materials and methods: From January to December 2015, 16 Shigella spp. were isolated from 310 non-duplicative diarrheal stool samples in Children's Medical Center, Tehran, Iran...
2018: GMS Hygiene and Infection Control
Paschoalina Romano, Maria da Luz Fernandes, Pérsio de Almeida Rezende Ebner, Nayara Duarte de Oliveira, Larissa Mitsue Okuda, Fabiana Agena, Maria Elizabete Mendes, Nairo Massakazu Sumita, Verônica Coelho, Elias David-Neto, Nelson Zocoler Galante
Monitoring tacrolimus (Tac) exposure in cell matrices enriched with lymphocytes can improve Tac therapeutic drug monitoring (TDM) in solid organ transplant recipients. An UPLC-MS/MS based assay for Tac quantification in peripheral blood T CD4+ and B CD19+ lymphocytes was developed. Peripheral blood mononuclear cells (PBMC) were obtained by density gradient centrifugation and highly purified (purity >90%) T CD4+ and B CD19+ cell suspensions were acquired by magnetic negative selection from whole blood of 6 healthy volunteers...
January 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Debbie Nisbet, Ann Robertson, Blessy Mannil, Vanessa Pincham, Andrew Mclennan
BACKGROUND: Nuchal translucency measurement has an established role in first trimester screening. Accurate measurement requires that technical guidelines are followed. Performance can be monitored by auditing the distribution of measurements obtained in a series of cases. AIMS: The primary aim is to develop an accessible, theory-based educational program for individuals whose distribution of measurements at audit falls outside an acceptable range, and assess operator performance following this intervention...
February 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
David A Giles, Nick Draper
Giles, DA and Draper, N. Heart rate variability during exercise: a comparison of artefact correction methods. J Strength Cond Res 32(3): 726-735, 2018-There is a need for standard practice in the collection and processing of RR interval data recorded using heart rate monitors (HRMs) in research. This article assessed the validity of RR intervals and heart rate variability (HRV) data obtained using an HRM during incremental exercise and artefact correction methods. Eighteen participants completed an active orthostatic test and incremental running V[Combining Dot Above]O2max test, while simultaneous recordings using a Polar V800 HRM and an electrocardiogram were made...
March 2018: Journal of Strength and Conditioning Research
Carly Loner, Nicole M Acquisto, Heather Lenhardt, Benjamin Sensenbach, Julie Purick, Courtney M C Jones, Jeremy T Cushman
OBJECTIVE: To assess the accuracy of multiple Intravenous Infusion Flow Regulators (IIFRs) at infusion rates and hanging heights common to the prehospital setting. METHODS: Five different manufacturer's IIFRs were tested over a range of infusion rates while hanging at heights equivalent to the gurney pole, ambulance ceiling hook, and manufacturer's recommended height (if available). Each IIFR was run over a 15-minute period at each infusion rate and height three times...
February 21, 2018: Prehospital Emergency Care
Pieter Martens, Hanne Beliën, Matthias Dupont, Wilfried Mullens
BACKGROUND: Sacubitril/valsartan significantly reduced heart failure hospitalization and mortality in PARADIGM-HF (Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor With an Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure). However, real-world data from its use are lacking. METHODS AND RESULTS: We retrospectively assessed all baseline and follow-up data of consecutive heart failure patients with reduced ejection fraction receiving therapy with sacubitril/valsartan for Class I recommendation between December 2016 and July 2017...
February 21, 2018: ESC Heart Failure
Gellért Karvaly, Krisztián Kovács, Katalin Mészáros, Ibolya Kocsis, Attila Patócs, Barna Vásárhelyi
The perturbation of the homeostasis of adrenocortical steroids plays a fundamental role in several pathological conditions. Currently, only a few of the substances involved in steroidogenesis are routinely analysed in clinical laboratories for the diagnosis of these conditions. Recently, interest has grown over the development of clinical assays of endogenous steroids using liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, no approaches have assessed the adrenocortical steroidogenesis comprehensively...
February 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Tiago Rosado, David Oppolzer, Belinda Cruz, Mário Barroso, Samira Varela, Victor Oliveira, Carlos Leitão, Eugenia Gallardo
RATIONALE: Antipsychotic drugs are prescription medications used to treat psychotic disorders, such as schizophrenia, schizoaffective disorder, or psychotic depression. With several antipsychotic drugs currently available all over the world, this class of drugs has quickly gotten importance in both clinical and forensic context. This work describes the development and validation of a methodology for the determination of seven antipsychotic drugs in plasma and oral fluid samples. METHODS: The antipsychotic drugs (chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, cyamemazine and, levomepromazine) were isolated from 0...
February 15, 2018: Rapid Communications in Mass Spectrometry: RCM
Giulia A Aldi, Giuly Bertoli, Francesca Ferraro, Aldo Pezzuto, Fiammetta Cosci
BACKGROUND: Smokers with major depressive disorder (MDD) or depressive symptoms (DS) represent a subgroup in need of attention since they have specific clinical features and prognosis. METHODS: A systematic review of the literature (Cochrane, MEDLINE, ScienceDirect, Web Of Science databases from inception to June 2017) of randomized clinical trials assessing the effectiveness of pharmacological, psychological or combined interventions for smoking cessation in subjects with current or past MDD/DS without medical or comorbid psychiatric disorder(s) was run following the PRISMA guidelines...
February 13, 2018: Substance Abuse
Scott D Peters, Garrett S Bullock, Adam P Goode, Grant E Garrigues, David S Ruch, Michael P Reiman
BACKGROUND: Ulnar collateral ligament injury (UCLI) has significantly increased in overhead sports during the past 2 decades. Differences in return to sport (RTS) and RTS at previous level (RTSP) after UCLI have not been differentiated. METHODS: A computer-assisted literature search of PubMed, CINAHL, Embase, and SportDiscus databases using keywords related to RTS for UCLI was implemented. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used for study methodology...
March 2018: Journal of Shoulder and Elbow Surgery
Bart C H van der Nagel, Sophie Wassenaar, Soma Bahmany, Birgit C P Koch
BACKGROUND: Detection of alcohol consumption after a longer period of time can be useful in certain patient groups. To monitor chronic alcohol consumption, a novel analytical method for the quantification of phosphatidylethanols (PEth) was developed and validated using ultra performance convergence chromatography tandem mass spectrometry. METHODS: The main phosphatidylethanols -Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (POPEth), 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphoethanol (PLPEth), and 1,2-Dioleoyl-sn-glycero-3-phosphoethanol (DOPEth) were analyzed using a simple and fast sample preparation protocol followed by chromatographic separation using ultra performance convergence chromatography, a novel kind of supercritical fluid chromatography...
February 8, 2018: Therapeutic Drug Monitoring
Liz Forbat, Karemah Francois, Lynne O'Callaghan, Julie Kulikowski
CONTEXT: Family meetings are increasingly used in palliative care, yet have little empirical evidence of their impact in in-patient settings. OBJECTIVES: To examine whether relatives report more empathy following a family meeting in a specialist palliative care in-patient ward. METHODS: Pre/post self-complete questionnaires measuring relational empathy and information needs were administered. Qualitative interviews were also conducted. Data were collected over nine months from one inpatient specialist palliative care unit...
February 6, 2018: Journal of Pain and Symptom Management
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