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https://www.readbyqxmd.com/read/28726691/an-exploratory-study-of-the-effects-of-stormwater-pipeline-materials-on-transported-stormwater-quality
#1
Matthias Borris, Heléne Österlund, Jiri Marsalek, Maria Viklander
Implications of three sewer pipe materials (concrete, galvanized corrugated steel, and polyvinyl chloride (PVC)) for stormwater quality were explored in laboratory experiments, in which three types of stormwater, SW1-SW3, were circulated in 0.5 m long sewer pipe sections. SW1 and SW2 represented synthetic rainwater, without and with fine street sediment added (CTSS = 150 mg/L), respectively, and SW3 was actual stormwater with the same sediment addition as SW2. Following 20-min runs, with an equivalent distance of 500 m travelled by water particles, a number of statistically significant changes in the stormwater chemistry were observed: (i) pH of all the simulated stormwaters increased in the concrete pipe (from 7...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28720639/angioedema-spotlight-a-closer-examination-of-sacubitril-valsartan-safety-results
#2
Ryan E Owens, Carrie S Oliphant
Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. While most of the discussion has focused on efficacy, a closer examination of the safety results, particularly the incidence of angioedema during the run-in and double-blind periods, is also warranted. Although no major safety concerns were identified, an angioedema risk comparable to enalapril was found, primarily in the black population...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720177/validation-of-multiresidue-method-for-analysis-of-31-pesticides-in-rice-using-gas-chromatography-tandem-mass-spectrometry
#3
Rahul Mondal, Ramen Kumar Kole, Anjan Bhttacharyya
Five modified QuEChERS were tested for the multiresidue analysis of 31 pesticides in rice. Rice was spiked with mixture solution of pesticides at 10 ng/g. Method selection was based on the LODs (sensitivity) and recovery tests (accuracy) of the pesticides. Analysis was done in GC-tandem MS in multiple reaction monitoring mode with a total run time of approximately 37 min. The selected method was validated after spiking rice at 20 and 100 ng/g in rice. The performance characteristics of the method impacted for all selected pesticides were acceptable according to the guidelines for method validation (recovery of 70-120% with an RSD of <20% and r2 value of ≥0...
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28720174/selective-determination-of-human-growth-hormone-somatropin-in-the-presence-of-its-chemical-degradation-products
#4
Mamdouh R Rezk, Marwa F Mohamed, Faten Abdelaziz Fathalla, Mostafa A Shehata
A rapid and sensitive HPLC method was developed and validated for selective determination of the human growth hormone (hGH) somatropin in the presence of its deamidated and oxidized degradation products. Reversed-phase chromatography with an acetonitrile and ammonium bicarbonate mobile phase in gradient elution mode was used. A short run time of 15 min allowed rapid and cost-effective analysis, with an average retention time of 7.4 min for native hGH, 6.2 min for its deamidated form, and 4.3 and 6 min for its oxidized variants...
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28718189/-health-related-quality-of-life-self-esteem-and-health-behaviour-on-average-6-years-after-an-obesity-outpatient-lifestyle-program
#5
Ingo Menrath, Angelika Gminder, Olaf Hiort, Ute Thyen
Background Multimodal programs focusing on weight reduction are recommended in guidelines for the treatment of obese children. However, studies investigating the effects of such programs over time are still missing; there is especially a lack of studies considering longer periods after treatment. In the present study, adolescents' bodyweight, health-related quality of life (HRQoL), self-esteem and health behavior were assessed before and directly after the treatment as well as 3 years after the treatment. Methods Between 2005 and 2009 84 children and adolescents took part in a 10-month, multimodal training programme...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28717618/plantar-fasciitis-in-athletes-diagnostic-and-treatment-strategies-a-systematic-review
#6
REVIEW
Federica Petraglia, Ileana Ramazzina, Cosimo Costantino
BACKGROUND: Plantar fasciitis (PF) is reported in different sports mainly in running and soccer athletes. Purpose of this study is to conduct a systematic review of published literature concerning the diagnosis and treatment of PF in both recreational and élite athletes. The review was conducted and reported in accordance with the PRISMA statement. METHODS: The following electronic databases were searched: PubMed, Cochrane Library and Scopus. As far as PF diagnosis, we investigated the electronic databases from January 2006 to June 2016, whereas in considering treatments all data in literature were investigated...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28712629/the-prime-diabetes-model-novel-methods-for-estimating-long-term-clinical-and-cost-outcomes-in-type-1-diabetes-mellitus
#7
William J Valentine, Richard F Pollock, Rhodri Saunders, Jay Bae, Kirsi Norrbacka, Kristina Boye
BACKGROUND: Recent publications describing long-term follow-up from landmark trials and diabetes registries represent an opportunity to revisit modeling options in type 1 diabetes mellitus (T1DM). OBJECTIVES: To develop a new product-independent model capable of predicting long-term clinical and cost outcomes. METHODS: After a systematic literature review to identify clinical trial and registry data, a model was developed (the PRIME Diabetes Model) to simulate T1DM progression and complication onset...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28712313/compulsory-military-service-as-a-measure-of-later-physical-and-cognitive-performance-in-male-survivors-of-childhood-cancer
#8
Ritva Ahomäki, Arja Harila-Saari, Kai Parkkola, Jaakko Matomäki, Päivi M Lähteenmäki
BACKGROUND: Compromised physical fitness and cognitive difficulties have been reported as late effects of cancer treatment during childhood. To assess this issue, the military rankings of cancer survivors in medical checkups at call-up, and conscripts' physical and cognitive performance during the first weeks of compulsory military education were compared to those of matched population controls without a history of cancer. MATERIAL AND METHODS: A total of 1680 male patients born between 1960 and 1992 with a malignancy diagnosed before the age of 16 who were alive at the call-up age (18 years) were identified using the Finnish Cancer Registry, and five age, sex and place of residence matched controls for each patient using the Population Register Centre...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28705226/continuous-surveillance-of-a-pregnancy-clinical-guideline-an-early-experience
#9
Laura Martínez García, Hector Pardo-Hernández, Andrea Juliana Sanabria, Pablo Alonso-Coello
BACKGROUND: To date there is no consensus about the optimal strategy for keeping clinical guidelines (CGs) up-to-date. The aims of this study were (1) to develop a continuous surveillance and updating strategy for CGs and (2) to test the strategy in a specific CG. METHODS: The main steps were as follows: (1) recruiting members for the CG Updating Working Group, (2) mapping the CG, (3) identifying new evidence from the CG Updating Working Group, (4) designing and running restricted literature searches, (5) reviewing drugs and medical devices alerts, (6) screening and assessing the new evidence, (7) reviewing and, if necessary, modifying clinical questions and recommendations, and (8) updating the CG document...
July 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28701460/clinician-self-efficacy-in-initiating-discussions-about-gestational-weight-gain
#10
Helena Piccinini-Vallis
OBJECTIVE: To compare prenatal care providers' perceived self-efficacy in starting discussions about gestational weight gain with pregnant women under a variety of conditions of gradated difficulty, when weight gain has been in excess of current guidelines. DESIGN: A 42-item online questionnaire related to the known barriers to and facilitators of having discussions about gestational weight gain. SETTING: Canada. PARTICIPANTS: Prenatal care providers were contacted through the Family Medicine Maternity Care list server of the College of Family Physicians of Canada...
July 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28699839/validated-low-volume-immunoassay-for-the-reliable-determination-of-direct-renin-especially-valuable-for-pediatric-investigations
#11
J Schaefer, B B Burckhardt, J Tins, A Bartel, S Laeer
INTRODUCTION: The pharmacotherapy of pediatric patients suffering from heart failure is extrapolated from adults due to missing data in children. OBJECTIVES: Development and validation of a low-volume immunoassay for the reliable determination of renin. EXPERIMENTAL: The immunoassay was validated according to international guidelines. RESULTS: The assay allows the reliable determination of renin in 40 μL plasma within a calibration range of 4 - 128 pg/mL...
July 12, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28693386/development-methodology-of-the-novel-endoscopic-stone-treatment-step-1-est-s1-training-assessment-curriculum
#12
Domenico Veneziano, Kamran Ahmed, Ben S E P Van Cleynenbreugel, Ali Serdar Gözen, Joan Palou, Kemal Sarica, Evangelos N Liatsikos, Francesco Sanguedolce, Patrick Honeck, Mario Alvarez-Maestro, Athanasios Papatsoris, Panagiotis Kallidonis, Francesco Greco, Alberto Breda, Bhaskar Somani
Background Simulation based technical-skill assessment is a core topic of debate, especially in high-risk environments. After the introduction of the E-BLUS exam for basic laparoscopy, no more technical training/assessment urological protocols have been developed in Europe. Objective We describe the methodology used in the development of the novel Endoscopic Stone Treatment step 1 (EST s1) assessment curriculum. Materials and Methods The "full life cycle curriculum development" template was followed for curriculum development...
July 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28666228/high-throughput-quantification-of-8-antihypertensive-drugs-and-active-metabolites-in-human-plasma-using-uplc-ms-ms
#13
Bart C H van der Nagel, Jorie Versmissen, Soma Bahmany, Teun van Gelder, Birgit C P Koch
BACKGROUND: To assess drug adherence of patients with hypertension, an analytical method was developed and validated using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The method includes eight frequently prescribed antihypertensive drugs from four classes and their active metabolites: angiotensin converting enzyme inhibitors enalapril and perindopril (active metabolites respectively enalaprilate and perindoprilate), angiotensin II receptor blockers losartan (with the active metabolite losartan carboxylic acid) and valsartan, calcium channel blockers amlodipine and nifedipine and diuretics hydrochlorothiazide and spironolactone (with the active metabolite canrenone)...
June 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28658739/targeted-screening-and-safety-evaluation-of-276-agrochemical-residues-in-raisins-using-buffered-ethyl-acetate-extraction-and-liquid-chromatography-tandem-mass-spectrometry-analysis
#14
T P Ahammed Shabeer, Manjusha Jadhav, Rushali Girame, Sandip Hingmire, Aarti Bhongale, Anjali Pudale, Kaushik Banerjee
A buffered ethyl acetate extraction method was optimized and validated in raisin matrix to monitor 276 pesticides by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The final method involved homogenization of raisinsalong with water 1:1 raisins: water followed by extraction using ethyl acetate (10 mL/10 g raisins homogenate in presence of 0.1 mL acetic acid, 0.5 g sodium acetate and 10 g sodium sulfate, and cleanup by dispersive solid phase extraction with primary secondary amine sorbent (25 mg/5 mL extract)...
June 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28652955/perioperative-fasting-and-the-patient-experience
#15
Telliane Chon, Alfred Ma, Connie Mun-Price
Standard preparation for a surgical procedure requires patients to fast (nulla per os [NPO]) after midnight before their operation. Unfortunately, given the unpredictable nature of operating room scheduling and unavoidable delays, patients may find themselves anxiously waiting and fasting much longer than expected. In recent years, the usefulness of prolonged fasting to prevent pulmonary aspiration has been questioned. According to the American Society of Anesthesiologists (ASA) guidelines, unnecessarily prolonged fasting can be avoided by allowing patients to have clear liquids with the minimal fasting time of only two hours...
May 24, 2017: Curēus
https://www.readbyqxmd.com/read/28649433/on-the-performance-of-de-novo-pathway-enrichment
#16
Richa Batra, Nicolas Alcaraz, Kevin Gitzhofer, Josch Pauling, Henrik J Ditzel, Marc Hellmuth, Jan Baumbach, Markus List
De novo pathway enrichment is a powerful approach to discover previously uncharacterized molecular mechanisms in addition to already known pathways. To achieve this, condition-specific functional modules are extracted from large interaction networks. Here, we give an overview of the state of the art and present the first framework for assessing the performance of existing methods. We identified 19 tools and selected seven representative candidates for a comparative analysis with more than 12,000 runs, spanning different biological networks, molecular profiles, and parameters...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28643276/a-rapid-two-step-iduronate-2-sulfatatse-enzymatic-activity-assay-for-mpsii-pharmacokinetic-assessment
#17
Mitra Azadeh, Luying Pan, Yongchang Qiu, Ruben Boado
Clinical studies involving enzyme replacement therapies (ERTs) have increasingly utilized enzymatic activity assays to monitor efficacy and biofunction of the drug; as a result, these assays have become an important part of pharmacokinetic (PK) and pharmacodynamic assessments in ERT trials. This paper presents a two-step enzymatic activity assay for iduronate-2-sulfatase (I2S) (EC 3.1.6.13) which we have optimized to fit in 1 day and to complete in less than 6 h. The rapid assay presented here is a significant improvement over the original two-step method with run time of 24 h which spanned 2 days...
June 23, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28639551/facet-joint-injections-for-people-with-persistent-non-specific-low-back-pain-facet-injection-study-a-feasibility-study-for-a-randomised-controlled-trial
#18
David R Ellard, Martin Underwood, Felix Achana, James Hl Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu
BACKGROUND: The National Institute for Health and Care Excellence (NICE) 2009 guidelines for persistent low back pain (LBP) do not recommend the injection of therapeutic substances into the back as a treatment for LBP because of the absence of evidence for their effectiveness. This feasibility study aimed to provide a stable platform that could be used to evaluate a randomised controlled trial (RCT) on the clinical effectiveness and cost-effectiveness of intra-articular facet joint injections (FJIs) when added to normal care...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28630733/return-to-running-after-arthroscopic-hip-surgery-literature-review-and-proposal-of-a-physical-therapy-protocol
#19
REVIEW
Matthew J Kraeutler, Joy Anderson, Jorge Chahla, Justin J Mitchell, Robyn Thompson-Etzel, Omer Mei-Dan, Cecilia Pascual-Garrido
The number of hip arthroscopy procedures has significantly increased in the last several years, thereby necessitating individualized rehabilitation protocols for patients following hip arthroscopy. The purpose of this article is to review the literature on rehabilitation protocols for patients following hip arthroscopy and to describe a new protocol specifically designed for patients to return to running following hip arthroscopy. A search of PubMed was performed through October 2016 to locate studies of rehabilitation protocols for patients wishing to return to sport/general activity following hip arthroscopy...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630722/hip-arthroscopy-protocol-expert-opinions-on-post-operative-weight-bearing-and-return-to-sports-guidelines
#20
Ehud Rath, Zachary T Sharfman, Matan Paret, Eyal Amar, Michael Drexler, Nicolas Bonin
The objectives of this study are to survey the weight-bearing limitation practices and delay for returning to running and impact sports of high volume hip arthroscopy orthopedic surgeons. The study was designed in the form of expert survey questionnaire. Evidence-based data are scares regarding hip arthroscopy post-operative weight-bearing protocols. An international cross-sectional anonymous Internet survey of 26 high-volume hip arthroscopy specialized surgeons was conducted to report their weight-bearing limitations and rehabilitation protocols after various arthroscopic hip procedures...
January 2017: Journal of Hip Preservation Surgery
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