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https://www.readbyqxmd.com/read/29149880/analytical-performance-of-envisia-a-genomic-classifier-for-usual-interstitial-pneumonia
#1
Yoonha Choi, Jiayi Lu, Zhanzhi Hu, Daniel G Pankratz, Huimin Jiang, Manqiu Cao, Cristina Marchisano, Jennifer Huiras, Grazyna Fedorowicz, Mei G Wong, Jessica R Anderson, Edward Y Tom, Joshua Babiarz, Urooj Imtiaz, Neil M Barth, P Sean Walsh, Giulia C Kennedy, Jing Huang
BACKGROUND: Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of the chest, the results are often inconclusive, making surgical lung biopsy necessary to reach a definitive diagnosis (Raghu et al., Am J Respir Crit Care Med 183(6):788-824, 2011). The Envisia genomic classifier differentiates UIP from non-UIP pathology in transbronchial biopsies (TBB), potentially allowing patients to avoid an invasive procedure (Brown et al...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29149735/carbamazepine-lamotrigine-levetiracetam-and-valproic-acid-in-dried-blood-spots-with-liquid-chromatography-tandem-mass-spectrometry-method-development-and-validation
#2
Camilla Linder, Anna Hansson, Sara Sadek, Lars L Gustafsson, Anton Pohanka
Monitoring of antiepileptic drugs in children with epilepsy require multiple visits at a clinic for blood collection. Dried blood spot sampling is an alternative way of collection, performed at home by self-collection and can save time and costs for patients and family members. The aim was to develop and validate an LC-MS/MS dried blood spot method for carbamazepine, lamotrigine, levetiracetam and valproic acid with the requirements of using standard equipment and material in a routine laboratory setting. Whatman-903 filter paper was utilized, and discs were punched into a 96 well plate with an automated puncher and barcode reading...
November 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29148163/development-and-validation-of-a-high-performance-liquid-chromatography-method-for-determination-of-lisinopril-in-human-plasma-by-magnetic-solid-phase-extraction-and-pre-column-derivatization
#3
Noushin Rastkari, Reza Ahmadkhaniha
A sensitive, reliable and simple HPLC method was developed for the determination of lisinopril in human plasma. The method consists of extraction and clean-up steps based on magnetic solid-phase extraction and pre-column derivatization with a fluorescent reagent. The mobile phase consisted of a mixture of methanol-sodium dihydrogen phosphate (pH 3.0; 0.005 m; 75:25, v/v). The flow rate was set at 0.7 mL/min. Fluorescence detection was performed at 470nm excitation and 530nm emission wavelengths. Total chromatography run time was 5 min...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29145097/lc-esi-ms-ms-determination-of-defactinib-a-novel-fak-inhibitor-in-mice-plasma-and-its-application-to-a-pharmacokinetic-study-in-mice
#4
Gurulingappa Hallur, Natarajan Tamizharasan, Suresh P Sulochana, Neeraj Kumar Saini, Mohd Zainuddin, Ramesh Mullangi
A sensitive, specific, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of defactinib in mice plasma using (13)C3,(15)N-tofacitinib as an internal standard (I.S.). Sample preparation was accomplished through a liquid-liquid extraction process. Baseline chromatographic resolution of defactinib and the I.S. was achieved on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (25:75, v/v) delivered at a flow rate of 0...
November 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29142545/rapid-screening-of-pyogenic-staphylococcus-aureus-for-confirmation-of-genus-and-species-methicillin-resistance-and-virulence-factors-by-using-two-novel-multiplex-pcr
#5
Abdul Haque, Asma Haque, Muhammad Saeed, Aysha Azhar, Samreen Rasool, Sidra Shan, Beenish Ehsan, Zohaib Nisar
Objectives: Emergence of methicillin resistant Staphylococcus aureus (MRSA) is a major medical problem of current era. These bacteria are resistant to most drugs and rapid diagnosis can provide a clear guideline to clinicians. They possess specific virulence factors and relevant information can be very useful. We designed this study to develop multiplex PCRs to provide rapid information. Methods: We studied 60 Staphylococcus aureus isolates and detected methicillin resistance by cefoxitin sensitivity and targeting of mecA gene...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29140606/mr-textural-analysis-on-t2-flair-images-for-the-prediction-of-true-oligodendroglioma-by-the-2016-who-genetic-classification
#6
Wenting Rui, Yan Ren, Yin Wang, Xinyi Gao, Xiao Xu, Zhenwei Yao
BACKGROUND: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria. PURPOSE: To assess the value of magnetic resonance textural analysis (MRTA) on T2 fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines...
November 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29121500/validation-of-a-salmonella-loop-mediated-isothermal-amplification-assay-in-animal-food
#7
Kelly J Domesle, Qianru Yang, Thomas S Hammack, Beilei Ge
Loop-mediated isothermal amplification (LAMP) has emerged as a promising alternative to PCR for pathogen detection in food testing and clinical diagnostics. This study aimed to validate a Salmonella LAMP method run on both turbidimetry (LAMP I) and fluorescence (LAMP II) platforms in representative animal food commodities. The U.S. Food and Drug Administration (FDA)'s culture-based Bacteriological Analytical Manual (BAM) method was used as the reference method and a real-time quantitative PCR (qPCR) assay was also performed...
October 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29112335/heterojunction-assisted-co3-s4-co3-o4-core-shell-octahedrons-for-supercapacitors-and-both-oxygen-and-carbon-dioxide-reduction-reactions
#8
Yibo Yan, Kaixin Li, Xiaoping Chen, Yanhui Yang, Jong-Min Lee
Expedition of electron transfer efficiency and optimization of surface reactant adsorption products desorption processes are two main challenges for developing non-noble catalysts in the oxygen reduction reaction (ORR) and CO2 reduction reaction (CRR). A heterojunction prototype on Co3 S4 @Co3 O4 core-shell octahedron structure is established via hydrothermal lattice anion exchange protocol to implement the electroreduction of oxygen and carbon dioxide with high performance. The synergistic bifunctional catalyst consists of p-type Co3 O4 core and n-type Co3 S4 shell, which afford high surface electron density along with high capacitance without sacrificing mechanical robustness...
November 7, 2017: Small
https://www.readbyqxmd.com/read/29106523/combining-watchman-left-atrial-appendage-closure-and-catheter-ablation-for-atrial-fibrillation-multicentre-registry-results-of-feasibility-and-safety-during-implant-and-30-days-follow-up
#9
Karen P Phillips, Evgeny Pokushalov, Aleksandr Romanov, Sergey Artemenko, Richard J Folkeringa, Tamas Szili-Torok, Gaetano Senatore, Kenneth M Stein, Omar Razali, Nicole Gordon, Lucas V A Boersma
Aims: Long-term results from catheter ablation therapy for atrial fibrillation (AF) remain uncertain and clinical practice guidelines recommend continuation of long-term oral anticoagulation in patients with a high stroke risk. Left atrial appendage closure (LAAC) with Watchman has emerged as an alternative to long-term anticoagulation for patients accepting of the procedural risks. We report on the initial results of combining catheter ablation procedures for AF and LAAC in a multicentre registry...
July 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29098077/surgical-assessment-clinic-one-stop-emergency-out-patient-clinic-for-rapid-assessment-reduced-admissions-and-improved-acute-surgical-service-a-quality-improvement-study
#10
Christina A W Macano, George C Kirby, Blossom Lake, Sitaramachandra M Nyasavajjala, Robert Clarke
Background: There is increasing pressure on emergency services within the NHS requiring efficient, rapid assessment and management of patients. A subsequent reduction in hospital admissions reduces overall costs with an aim to improve quality of care. At the Royal Shrewsbury Hospital we run a one stop emergency surgical clinic. With strict criteria for admission to this clinic we have established a care pathway for those patients requiring urgent surgical review but not necessarily hospital admission...
November 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29097516/planning-risk-based-sqc-schedules-for-bracketed-operation-of-continuous-production-analyzers
#11
James O Westgard, Hassan Bayat, Sten A Westgard
BACKGROUND: To minimize patient risk, "bracketed" statistical quality control (SQC) is recommended in the new CLSI guidelines for SQC (C24-Ed4). Bracketed SQC requires that a QC event both precedes and follows (brackets) a group of patient samples. In optimizing a QC schedule, the frequency of QC or run size becomes an important planning consideration to maintain quality and also facilitate responsive reporting of results from continuous operation of high production analytic systems. METHODS: Different plans for optimizing a bracketed SQC schedule were investigated on the basis of Parvin's model for patient risk and CLSI C24-Ed4's recommendations for establishing QC schedules...
November 2, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29090387/factors-influencing-non-participation-in-an-exercise-program-and-attitudes-towards-physical-activity-amongst-cancer-survivors
#12
Sarah J Hardcastle, Chloe Maxwell-Smith, Sviatlana Kamarova, Stephanie Lamb, Lesley Millar, Paul A Cohen
PURPOSE: The purposes of this study are to investigate factors influencing non-participation in a structured exercise program for cancer survivors and to explore survivors' experiences and attitudes in relation to physical activity participation. METHODS: Face-to-face or telephone interviews were conducted with individuals who had registered for, or engaged in, the 'Life Now' exercise program run by Cancer Council Western Australia. Participants were 20 cancer survivors (mean age 63...
October 31, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29082488/guidelines-for-microplate-selection-in-high-content-imaging
#13
Oscar J Trask
Since the inception of commercialized automated high content screening (HCS) imaging devices in the mid to late 1990s, the adoption of media vessels typically used to house and contain biological specimens for interrogation has transitioned from microscope slides and petri dishes into multi-well microtiter plates called microplates. The early 96- and 384-well microplates commonly used in other high-throughput screening (HTS) technology applications were often not designed for optical imaging. Since then, modifications and the use of next-generation materials with improved optical clarity have enhanced the quality of captured images, reduced autofocusing failures, and empowered the use of higher power magnification objectives to resolve fine detailed measurements at the subcellular pixel level...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29074093/a-new-hope-lessons-from-hope-3
#14
REVIEW
Travis M Howard, Aakash A Bavishi, Neil J Stone
Lifestyle medication is the cornerstone of preventing atherosclerotic cardiovascular disease (ASCVD). When this is not sufficient in reducing risk, statin therapy is first line. HOPE-3 was a randomized controlled trial of rosuvastatin vs placebo, which demonstrated a significant net benefit in a lower risk population without known atherosclerotic cardiovascular disease. There were many novel characteristics about this trial that should not be overlooked. It contained a diverse population and was the first trial to base inclusion solely on easily ascertainable metabolic risk factors...
October 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29065911/effectiveness-of-behavioral-change-techniques-employed-in-ehealth-interventions-designed-to-improve-glycemic-control-in-persons-with-poorly-controlled-type-2-diabetes-a-systematic-review-and-meta-analysis-protocol
#15
Mihiretu Kebede, Lara Christianson, Zohaib Khan, Thomas L Heise, Claudia R Pischke
BACKGROUND: The incorporation of Behavioral Change Techniques (BCTs) in eHealth interventions for the management of non-communicable diseases (NCDs), such as type 2 diabetes mellitus (T2DM), might be a promising approach to improve clinical and behavioral outcomes of NCDs in the long run. This 3paper reports a protocol for a systematic review that aims to (a) identify the effects of individual BCTs in eHealth interventions for lowering glycated hemoglobin levels (HbA1c) and (b) investigate which additional intervention features (duration of intervention, tailoring, theory-base, and mode of delivery) affect levels of HbA1c in this population...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29065247/international-collaborative-study-for-the-calibration-of-proposed-international-standards-for-thromboplastin-rabbit-plain-and-for-thromboplastin-recombinant-human-plain
#16
Antonius M H P van den Besselaar, Veena Chantarangkul, Franca Angeloni, Nikolaus B Binder, Mary Byrne, Raymond Dauer, Brynja R Gudmundsdottir, Jørgen Jespersen, Steven Kitchen, Cristina Legnani, Tomas L Lindahl, Richard A Manning, Marta Martinuzzo, Olga Panes, Vittorio Pengo, Anne Riddell, Sitalakshmi Subramanian, Attila Szederjesi, Chaicharoen Tantanate, Petra Herbel, Armando Tripodi
BACKGROUND: The availability of International Standards for thromboplastin is essential for the calibration of routine reagents and hence the calculation of the International Normalized Ratio (INR). Stocks of the current 4(th) International Standards are running low. Candidate replacement materials have been prepared. This report describes the calibration of the proposed 5(th) International Standards for thromboplastin, rabbit, plain (coded RBT/16) and for thromboplastin, recombinant, human, plain (coded rTF/16)...
October 24, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29061472/quantification-of-steroid-hormones-in-human-serum-by-liquid-chromatography-high-resolution-tandem-mass-spectrometry
#17
Silke Matysik, Gerhard Liebisch
A limited specificity is inherent to immunoassays for steroid hormone analysis. To improve selectivity mass spectrometric analysis of steroid hormones by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been introduced in the clinical laboratory over the past years usually with low mass resolution triple-quadrupole instruments or more recently by high resolution mass spectrometry (HR-MS). Here we introduce liquid chromatography-high resolution tandem mass spectrometry (LC-MS/HR-MS) to further increase selectivity of steroid hormone quantification...
December 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29053454/a-data-set-for-camera-independent-color-constancy
#18
Caglar Aytekin, Jarno Nikkanen, Moncef Gabbouj
In this paper, we provide a novel data set designed for Camera-independent color constancy research. Camera independence corresponds to the robustness of an algorithm's performance when it runs on images of the same scene taken by different cameras. Accordingly, the images in our database correspond to several laboratory and field scenes each of which is captured by three different cameras with minimal registration errors. The laboratory scenes are also captured under five different illuminations. The spectral responses of cameras and the spectral power distributions of the laboratory light sources are also provided, as they may prove beneficial for training future algorithms to achieve color constancy...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29051458/heavy-metal-pollution-of-chari-river-water-during-the-crossing-of-n-djamena-chad
#19
N'garam Nambatingar, Yohann Clement, Alain Merle, Tchadanaye New Mahamat, Pierre Lanteri
This study was carried out to identify and assess the water quality of the Chari River. The Chari, 1200 km long, is Chad's major water source. Municipal sewage, industrial wastewater discharge, and seasonal run-off from agriculture are regularly fed into the river. Several trace metals such as Cu, Zn, Fe, Ni, Cr, Mn, and Cd, were measured in different sampling stations located along the Chari River at N'Djamena in different campaigns from 2008 to 2010. Overall, manganese, zinc, chromium, and copper concentration levels were mainly in the range of the permissible limits prescribed by WHO guidelines (WHO 2011)...
October 12, 2017: Toxics
https://www.readbyqxmd.com/read/29045600/development-and-validation-of-a-stability-indicating-reversed-phase-uplc-uv-method-for-the-assay-of-imidacloprid-and-estimation-of-its-related-compounds
#20
Jingzhi Tian, Abu Rustum
Imidacloprid is used as an active pharmaceutical ingredient (API) in veterinary drugs to control fleas and ticks for dogs and cats. Here we are reporting for the first time a validated stability-indicating reversed-phase UPLC-UV method for the assay of imidacloprid and estimation of its related compounds. The stability-indicating capability of this method has been demonstrated by a forced degradation study. All related compounds including processing impurities, imidacloprid API and degradates from stressed samples were well separated from each other...
October 17, 2017: Journal of Chromatographic Science
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