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https://www.readbyqxmd.com/read/29792921/characterization-of-solution-stress-degradation-products-of-aliskiren-and-prediction-of-their-physicochemical-and-admet-properties
#1
Bhoopendra Singh Kushwah, Jugal Gupta, Dilip Kumar Singh, Moolchand Kurmi, Archana Sahu, Saranjit Singh
Forced degradation studies on aliskiren were carried out according to ICH and WHO guidelines. Six degradation products were formed in total in the solution state. Their separation among themselves and from the drug was successfully achieved on a C-18 column utilizing acetonitrile and phosphate buffer (pH 3.0) in the mobile phase, which was run in a gradient mode. To characterize them, a complete mass fragmentation pathway of the drug was first established with the help of MS/TOF and MSn data. This was followed by LC-MS/TOF studies on the degradation products...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792160/nextsv-a-meta-caller-for-structural-variants-from-low-coverage-long-read-sequencing-data
#2
Li Fang, Jiang Hu, Depeng Wang, Kai Wang
BACKGROUND: Structural variants (SVs) in human genomes are implicated in a variety of human diseases. Long-read sequencing delivers much longer read lengths than short-read sequencing and may greatly improve SV detection. However, due to the relatively high cost of long-read sequencing, it is unclear what coverage is needed and how to optimally use the aligners and SV callers. RESULTS: In this study, we developed NextSV, a meta-caller to perform SV calling from low coverage long-read sequencing data...
May 23, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29772904/why-cvd-grown-mos2-samples-outperform-pvd-samples-time-domain-ab-initio-analysis
#3
Linqiu Li, Run Long, Oleg V Prezhdo
Two-dimensional transition metal dichalcogenides (TMDs) have drawn strong attention due to their unique properties and diverse applications. However, TMD performance depends strongly on material quality and defect morphology. Experiments show that samples grown by chemical vapor deposition (CVD) outperform those obtained by physical vapor deposition (PVD). Experiments also show that CVD samples exhibit vacancy defects, while antisite defects are frequently observed in PVD samples. Our time-domain ab initio study demonstrates that both antisites and vacancies accelerate trapping and nonradiative recombination of charge carriers, but antisites are much more detrimental than vacancies...
May 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29768657/simultaneous-quantification-of-fentanyl-sufentanil-cefazolin-doxapram-and-keto-doxapram-in-plasma-using-liquid-chromatography-tandem-mass-spectrometry
#4
Robert B Flint, Soma Bahmany, Bart C H van der Nagel, Birgit C P Koch
A simple and specific UPLC-MS/MS method was developed and validated for simultaneous quantification of fentanyl, sufentanil, cefazolin, doxapram and its active metabolite keto-doxapram. The internal standard was fentanyl-d5 for all analytes. Chromatographic separation was achieved with a reversed phase Acquity UPLC HSS T3 column with a run-time of only 5.0 minutes per injected sample. Gradient elution was performed with a mobile phase consisting of ammonium acetate, formic acid in Milli-Q ultrapure water or in methanol with a total flow rate of 0...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29768457/choice-of-time-horizon-critical-in-estimating-costs-and-effects-of-changes-to-hiv-programmes
#5
Nicky McCreesh, Ioannis Andrianakis, Rebecca N Nsubuga, Mark Strong, Ian Vernon, Trevelyan J McKinley, Jeremy E Oakley, Michael Goldstein, Richard Hayes, Richard G White
BACKGROUND: Uganda changed its antiretroviral therapy guidelines in 2014, increasing the CD4 threshold for antiretroviral therapy initiation from 350 cells/μl to 500 cells/μl. We investigate what effect this change in policy is likely to have on HIV incidence, morbidity, and programme costs, and estimate the cost-effectiveness of the change over different time horizons. METHODS: We used a complex individual-based model of HIV transmission and antiretroviral therapy scale-up in Uganda...
2018: PloS One
https://www.readbyqxmd.com/read/29757053/applying-a-low-fodmap-dietary-intervention-to-a-female-ultra-endurance-runner-with-irritable-bowel-syndrome-during-a-multi-stage-ultra-marathon
#6
Stephanie K Gaskell, Ricardo J S Costa
Malabsorption of Fermentable Oligo- Di- and Mono-saccharides and Polyols (FODMAPs) in response to prolonged exercise may increase incidence of upper- and lower-gastrointestinal symptoms (GIS), which are known to impair exercise performance. The case-study aimed to explore the impact of a low-FODMAP diet on exercise-associated GIS in a female ultra-endurance runner diagnosed with irritable bowel syndrome (IBS), competing in a six-day 186.7 km mountainous multi-stage ultra-marathon (MSUM). IBS symptom severity score at diagnosis was 410 and following a low-FODMAP diet (3...
May 14, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29751617/cardiovascular-health-benefits-of-specific-vegetable-types-a-narrative-review
#7
REVIEW
Lauren C Blekkenhorst, Marc Sim, Catherine P Bondonno, Nicola P Bondonno, Natalie C Ward, Richard L Prince, Amanda Devine, Joshua R Lewis, Jonathan M Hodgson
Adequate vegetable consumption is one of the cornerstones of a healthy diet. The recommendation to increase vegetable intake is part of most dietary guidelines. Despite widespread and long-running public health messages to increase vegetable intake, similar to other countries worldwide, less than 1 in 10 adult Australians manage to meet target advice. Dietary guidelines are predominantly based on studies linking diets high in vegetables with lower risk of chronic diseases. Identifying vegetables with the strongest health benefits and incorporating these into dietary recommendations may enhance public health initiatives around vegetable intake...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29746359/evaluation-of-a-focused-cardiac-ultrasound-protocol-in-a-pediatric-emergency-department
#8
Antonio Riera, Bevin Weeks, Beth L Emerson, Lei Chen
OBJECTIVES: The objective of this study was to evaluate the implementation of a focused cardiac ultrasound (FoCUS) protocol in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional, observational, quality improvement project in a PED of an urban tertiary care children's hospital. A FoCUS protocol was collaboratively developed by pediatric cardiology and pediatric emergency medicine. This included a reference document with definitions, indications, image acquisition guidelines, and interpretation expectations...
May 9, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#9
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29734052/critical-analysis-of-forensic-cut-offs-and-legal-thresholds-a-coherent-approach-to-inference-and-decision
#10
A Biedermann, F Taroni, S Bozza, M Augsburger, C G G Aitken
In this paper we critically discuss the definition and use of cut-off values by forensic scientists, for example in forensic toxicology, and point out when and why such values - and ensuing categorical conclusions - are inappropriate concepts for helping recipients of expert information with their questions of interest. Broadly speaking, a cut-off is a particular value of results of analyses of a target substance (e.g., a toxic substance or one of its metabolites in biological sample from a person of interest), defined in a way such as to enable scientists to suggest conclusions regarding the condition of the person of interest...
April 25, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29733891/-connecting-worlds-a-view-on-microfluidics-for-a-wider-application
#11
REVIEW
Ana C Fernandes, Krist V Gernaey, Ulrich Krühne
From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices...
May 4, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29730488/the-use-of-wearable-devices-for-walking-and-running-gait-analysis-outside-of-the-lab-a-systematic-review
#12
REVIEW
Lauren C Benson, Christian A Clermont, Eva Bošnjak, Reed Ferber
BACKGROUND: Quantitative gait analysis is essential for evaluating walking and running patterns for markers of pathology, injury, or other gait characteristics. It is expected that the portability, affordability, and applicability of wearable devices to many different populations will have contributed advancements in understanding the real-world gait patterns of walkers and runners. Therefore, the purpose of this systematic review was to identify how wearable devices are being used for gait analysis in out-of-lab settings...
May 1, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29730074/defining-the-characteristics-of-certified-hernia-centers-in-italy-the-italian-society-of-hernia-and-abdominal-wall-surgery-workgroup-consensus-on-systematic-reviews-of-the-best-available-evidences
#13
REVIEW
Cesare Stabilini, Giuseppe Cavallaro, Paolo Bocchi, Giampiero Campanelli, Michele Carlucci, Francesca Ceci, Feliciano Crovella, Diego Cuccurullo, Landino Fei, Ezio Gianetta, Francesco Gossetti, Dalila Patrizia Greco, Olga Iorio, Pierluigi Ipponi, Antonio Marioni, Giovanni Merola, Paolo Negro, Denise Palombo, Umberto Bracale
BACKGROUND: The terms "Hernia Center" (HC) and Hernia Surgeon" (HS) have gained more and more popularity in recent years. Nevertheless, there is lack of protocols and methods for certification of their activities and results. The Italian Society of Hernia and Abdominal Wall Surgery proposes a method for different levels of certification. METHODS: The national board created a commission, with the task to define principles and structure of an accreditation program...
May 3, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29724380/exercise-induced-bronchospasm-in-children-and-adolescents-with-allergic-rhinitis-by-treadmill-and-hyperventilation-challenges
#14
Edil de Albuquerque Rodrigues Filho, José Ângelo Rizzo, Adriana Velozo Gonçalves, Marco Aurélio de Valois Correia Junior, Emanuel Sávio Cavalcanti Sarinho, Décio Medeiros
BACKGROUND: Respiratory complaints after exercise are common in patients with rhinitis. Exercise-induced bronchospasm (EIB) may be one of the causes. OBJECTIVES: To evaluate EIB prevalence in a group of children and adolescents with allergic rhinitis, to compare the treadmill running (TR) and eucapnic voluntary hyperventilation (EVH) challenge methods as diagnostic tools and to assess the association between respiratory complaints on exercise and EIB. METHODS: Patients aged between 10 and 20 years were studied at the Pulmonology Department of the Hospital das Clínicas -UFPE- Recife, Brazil...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29709751/safety-of-running-two-rooms-a-systematic-review-and-meta-analysis-of-overlapping-neurosurgical-procedures
#15
D Mitchell Self, Adeel Ilyas, William R Stetler
OBJECTIVE: Overlapping surgery, a long-standing practice within academic neurosurgery centers nationwide, has recently come under scrutiny from the government and media as potentially harmful to patients. Therefore, the objective of this systematic review and meta-analysis is to determine the safety of overlapping neurosurgical procedures. METHODS: The authors performed a systematic review and meta-analysis in accordance with PRISMA guidelines. A review of PubMed and Medline databases was undertaken with the search phrase "overlapping surgery AND neurosurgery AND outcomes...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29708876/quantification-of-vanillylmandelic-acid-homovanillic-acid-and-5-hydroxyindoleacetic-acid-in-urine-using-a-dilute-and-shoot-and-ultra-high-pressure-liquid-chromatography-tandem-mass-spectrometry-method
#16
Eric Grouzmann, Catherine Centeno, Philippe J Eugster
BACKGROUND: Urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) are biomarkers for the diagnosis and follow-up of neuroblastoma, whereas urinary 5-hydroxyindoleacetic acid (5-HIAA) is used to assess a carcinoid tumor. These analytes are conventionally analyzed in a single run by chromatography (LC) coupled with electrochemical detection (LC-ECD) using commercial kits. A rapid dilute-and-shoot LC tandem mass spectrometry (LC-MS/MS) assay was validated in order to replace the LC-ECD method and therefore improve analytical specificity and throughput...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29706462/cost-effectiveness-analysis-of-stereotactic-body-radiotherapy-and-surgery-for-medically-operable-early-stage-non-small-cell-lung-cancer
#17
Adrien Paix, Georges Noel, Pierre-Emmanuel Falcoz, Pierre Levy
BACKGROUND: Projections estimate an increase of 50% of the incidence of lung cancer by 2030. Early-stage non-small cell lung cancer represented 19% of NSCLC cases diagnosed in the US between 2005 and 2011. There is rising evidence in favour of lung cancer screening, which will reduce the occurrence of later-stage lung cancers while raising the incidence of early-stage NSCLC. Current guidelines state that for early-stage NSCLC, surgical resection should be performed, and stereotactic body radiotherapy (SBRT) is an option for patients who are non-medically operable...
April 26, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29685281/silage-review-safety-considerations-during-silage-making-and-feeding
#18
REVIEW
Keith K Bolsen
Silage-related injury knows no age boundary as workers and bystanders of all ages have been killed in silage accidents. Even the best employee can become frustrated with malfunctioning equipment and poor weather conditions and take a hazardous shortcut, or misjudge a situation and take a risky action. At least 6 hazards are encountered in managing silage in bunker silos and drive-over piles that endanger lives: tractor or truck rollover, run-over by or entanglement in machinery, fall from height, crushing by an avalanche or collapsing silage, silage gases, and complacency or fatigue...
May 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29680456/defining-level-a-ivivc-dissolution-specifications-based-on-individual-in-vitro-dissolution-profiles-of-a-controlled-release-formulation
#19
I González-García, A García-Arieta, M Merino-Sanjuan, V Mangas-Sanjuan, M Bermejo
Regulatory guidelines recommend that, when a level A IVIVC is established, dissolution specification should be established using averaged data and the maximum difference between AUC and Cmax between the reference and test formulations cannot be greater than 20%. However, averaging data assumes a loss of information and may reflect a bias in the results. The objective of the current work is to present a new approach to establish dissolution specifications using a new methodology (individual approach) instead of average data (classical approach)...
April 20, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29678588/how-to-run-molecular-dynamics-simulations-on-electrospray-droplets-and-gas-phase-proteins-basic-guidelines-and-selected-applications
#20
REVIEW
Lars Konermann, Haidy Metwally, Robert G McAllister, Vlad Popa
The ability to transfer intact proteins and protein complexes into the gas phase by electrospray ionization (ESI) has opened up numerous mass spectrometry (MS)-based avenues for exploring biomolecular structure and function. However, many details regarding the ESI process and the properties of gaseous analyte ions are difficult to decipher when relying solely on experimental data. Molecular dynamics (MD) simulations can provide additional insights into the behavior of ESI droplets and protein ions. This review is geared primarily towards experimentalists who wish to adopt MD simulations as a complementary research tool...
April 17, 2018: Methods: a Companion to Methods in Enzymology
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