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https://www.readbyqxmd.com/read/28544884/a-validated-uhplc-qtof-ms-method-for-quantification-of-metformin-and-teneligliptin-in-rat-plasma-application-to-pharmacokinetic-interaction-study
#1
David Paul, Lingesh Allakonda, Nanjappan Satheeshkumar
In this study a sensitive UHPLC-QTOF-MS method was developed and validated for the quantitation of the metformin (MET) and teneligliptin (TEN) in rat plasma using dapagliflozin as an internal standard (IS). Chromatographic separation were carried out on a Acquity UPLC HSS Cyano column (100mm x 2.1mm, 1.8μm) using gradient mobile phase system consisting of 0.1% formic acid and acetonitrile at a flow rate of 0.4mL/min, within a run time of 6min. Protein precipitation method was used as sample preparation approach...
May 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28535452/highly-sensitive-uhplc-ms-ms-method-for-the-simultaneous-estimation-of-propafenone-and-its-metabolites-5-hydroxypropafenone-and-n-depropylpropafenone-on-human-dried-blood-spots-technique-and-application-to-a-pharmacokinetic-study
#2
Adinarayana Andy, Raja Reddy Kallem, Ramesh Mullangi, Divya Andy, J V L N Seshagiri Rao
A highly sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for quantification of the propafenone (PF), 5-hydroxypropafenone (5-OHPF) and N-depropylpropafenone (N-DPF) on human dried blood spot (DBS). The assay procedure involves a solid-liquid extraction of PF, 5-OHPF and N-DPF and amlodipine (internal standard, I.S.) from dried human DBS cards using water and acetonitrile. The chromatographic resolution was achieved on a BEH C18 column using a gradient mobile phase consisting of 0...
May 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#3
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28524327/evaluation-of-a-multi-methods-approach-to-the-collection-and-dissemination-of-feedback-on-osce-performance-in-dental-education
#4
M J Wardman, V C Yorke, J L Hallam
INTRODUCTION: Feedback is an essential part of the learning process, and students expect their feedback to be personalised, meaningful and timely. Objective Structured Clinical Examination (OSCE) assessments allow examiners to observe students carefully over the course of a number of varied station types, across a number of clinical knowledge and skill domains. They therefore present an ideal opportunity to record detailed feedback which allows students to reflect on and improve their performance...
May 19, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28511118/simultaneous-determination-of-selective-serotonin-reuptake-inhibitors-and-their-main-metabolites-in-human-breast-milk-by-liquid-chromatography-electrospray-mass-spectrometry
#5
Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka, Chin B Eap, Nicolas Ansermot
A bioanalytical method by high performance liquid chromatography coupled to electrospray mass spectrometry (HPLC-ESI-MS), adapted from a previously published method in plasma, was validated in breast milk for the simultaneous quantification of all antidepressants belonging to the class of selective serotonin reuptake inhibitors (citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) and their major metabolites (desmethylcitalopram and norfluoxetine). Milk samples (250μl) first underwent protein precipitation followed by solid-phase extraction on a reversed phase/cation exchange sorbent...
July 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28510467/association-between-physicians-adherence-to-a-pharmacotherapy-guideline-and-continuity-of-care-for-patients-with-depression-and-or-anxiety-disorder
#6
Elham Heidari, Saeid Eslami, Farid Abolhassani, Vandad Sharifi, Zhila Taherzadeh, Tahoura Daneshvar
OBJECTIVE: The aim of the paper is to investigate the association between physicians' adherence to a pharmacotherapy guideline and continuity of care for patients with depressive and/or anxiety disorders in a collaborative care program. METHODS: This retrospective observational study was conducted using medical records of subjects suffering from depression and/or anxiety disorder visited by 26 general practitioners (GP) working with  Community Mental Health Center (CMHC), who run a collaborative care program in Tehran, Iran...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28510464/a-stakeholder-perspective-on-diabetes-mellitus-and-diabetic-retinopathy-care-in-iran-a-qualitative-study
#7
Marzieh Katibeh, Masumeh Kalantarion, Silvio Paolo Mariotti, Sare Safi, Saeid Shahraz, Per Kallestrup, Saeed Rahmani, Seyed-Farzad Mohammadi, Alireza Mahdavi, Hamid Ahmadieh
OBJECTIVE: To assess the national health system for management of diabetes mellitus (DM) in Iran, with particular focus on diabetic retinopathy (DR). MATERIALS AND METHODS: In this qualitative study, the national stakeholders related to DR and DM management system were invited to participate. Two researchers performed interview using a semi-structured questionnaire recommended by the World Health Organization titled "Tool for Assessment of Diabetic Retinopathy and DM Management Systems"...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28507981/a-quasi-experimental-study-of-a-movement-and-preliteracy-program-for-3-and-4-year-old-children
#8
Chloe Bedard, Emily Bremer, Wenonah Campbell, John Cairney
OBJECTIVE: Approximately 28% of children are not ready for kindergarten, 91% are inactive according to current guidelines, and 21% are overweight/obese. Early intervention to strengthen movement and preliteracy skills may help to curb the concerning rates of poor school readiness, inactivity, obesity, and subsequently positively impact health across the lifespan. The objective of this pilot study was to evaluate the effectiveness of a motor and preliteracy skill program for a community sample of 3- to 4-year-old children...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28505076/comprehensive-and-highly-accurate-measurements-of-crane-runways-profiles-and-fastenings
#9
Dirk Dennig, Johannes Bureick, Johannes Link, Dmitri Diener, Christian Hesse, Ingo Neumann
The process of surveying crane runways has been continually refined due to the competitive situation, modern surveying instruments, additional sensors, accessories and evaluation procedures. Guidelines, such as the International Organization for Standardization (ISO) 12488-1, define target values that must be determined by survey. For a crane runway these are for example the span, the position and height of the rails. The process has to be objective and reproducible. However, common processes of surveying crane runways do not meet these requirements sufficiently...
May 13, 2017: Sensors
https://www.readbyqxmd.com/read/28499151/biphenyl-based-stationary-phases-for-improved-selectivity-in-complex-steroid-assays
#10
Johanna M Lindner, Michael Vogeser, Stefanie H Grimm
The measurement of steroid hormones and their corticoid precursors is an important aspect in endocrinology since these analytes are biomarkers for several endocrine disorders. Over the last few years, HPLC-MS/MS has become the method of choice to analyze these compounds. There are already several methods using stationary phases modified with C18 groups. However, since these columns sometimes do not enable sufficient separation of some isobaric steroids, we investigated the potential of a different RP modification using biphenyl groups for the separation of challenging isobars such as corticosterone, 11- and 21-deoxycortisol...
April 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28497926/plasma-lte4-pgf2%C3%AE-ratio-and-blood-eosinophil-count-are-increased-in-elderly-asthmatics-with-previous-asthma-exacerbation
#11
Ga Young Ban, Young Min Ye, Sang Ha Kim, Gyu Young Hur, Joo Hee Kim, Jae Jung Shim, Kumsun Cho, Joo Youn Cho, Hae Sim Park
The tools for asthma control assessment recommended by the current guideline are cognitive function- and effort-dependent, which is substantially impaired in the elderly. The aim of this study is to investigate objective assessment tools of asthma control status and previous asthma exacerbation (AE) in elderly subjects. Asthmatics aged >60 years who were treated with step 2 or 3 by the Global Initiative for Asthma (GINA) guideline were enrolled. During the 12-week study period, the subjects used either 400 μg of budesonide plus 10 mg of montelukast or 800 μg of inhaled budesonide...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28494358/herbicide-effects-on-the-growth-and-photosynthetic-efficiency-of-cassiopea-maremetens
#12
David J Rowen, Michelle A Templeman, Michael J Kingsford
Herbicides from agricultural run-off have been measured in coastal systems of the Great Barrier Reef over many years. Non-target herbicide exposure, especially photosystem II herbicides has the potential to affect seagrasses and other marine species. The symbiotic benthic jellyfish Cassiopea maremetens is present in tropical/sub-tropical estuarine and marine environments. Jellyfish (n = 8 per treatment) were exposed to four separate concentrations of agricultural formulations of diuron or hexazinone to determine their sensitivity and potential for recovery to pulsed herbicide exposure...
May 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28483925/msstatsqc-longitudinal-system-suitability-monitoring-and-quality-control-for-targeted-proteomic-experiments
#13
Eralp Dogu, Sara Mohammad-Taheri, Susan E Abbatiello, Michael S Bereman, Brendan MacLean, Birgit Schilling, Olga Vitek
Selected Reaction Monitoring (SRM) is a powerful tool for targeted detection and quantification of peptides in complex matrices. An important objective of SRM is to obtain peptide quantifications that are (1) suitable for the purpose of the investigation, and (2) reproducible across laboratories and runs. The first objective is achieved by system suitability tests (SST), which verify that mass spectrometric instrumentation performs as specified. The second objective is achieved by quality control (QC), which provides in-process quality assurance of the sample profile...
May 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28483249/effect-of-gentamicin-and-levels-of-ambient-sound-on-hearing-screening-outcomes-in-the-neonatal-intensive-care-unit-a-pilot-study
#14
Angela C Garinis, Selena Liao, Campbell P Cross, Johnathan Galati, Jessica L Middaugh, Jess C Mace, Anna-Marie Wood, Lindsey McEvoy, Lauren Moneta, Troy Lubianski, Noe Coopersmith, Nicholas Vigo, Christopher Hart, Artur Riddle, Olivia Ettinger, Casey Nold, Heather Durham, Carol MacArthur, Cynthia McEvoy, Peter S Steyger
OBJECTIVE: Hearing loss rates in infants admitted to neonatal intensive care units (NICU) run at 2-15%, compared to 0.3% in full-term births. The etiology of this difference remains poorly understood. We examined whether the level of ambient sound and/or cumulative gentamicin (an aminoglycoside) exposure affect NICU hearing screening results, as either exposure can cause acquired, permanent hearing loss. We hypothesized that higher levels of ambient sound in the NICU, and/or gentamicin dosing, increase the risk of referral on the distortion product otoacoustic emission (DPOAE) assessments and/or automated auditory brainstem response (AABR) screens...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28480828/hierarchical-models-for-sharing-information-across-populations-in-phase-i-dose-escalation-studies
#15
Kristen M Cunanan, Joseph S Koopmeiners
The primary goal of a phase I clinical trial in oncology is to evaluate the safety of a novel treatment and identify the maximum tolerated dose, defined as the maximum dose with a toxicity rate below some pre-specified threshold. Researchers are often interested in evaluating the performance of a novel treatment in multiple patient populations, which may require multiple phase I trials if the treatment is to be used with background standard-of-care that varies by population. An alternate approach is to run parallel trials but combine the data through a hierarchical model that allows for a different maximum tolerated dose in each population but shares information across populations to achieve a more accurate estimate of the maximum tolerated dose...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28478828/tidal-chemotherapy-in-premenopausal-patients-with-hormone-receptor-positive-breast-cancer
#16
Qing-Qing Luo, Jian-Bo Huang, Yu-Tuan Wu, Xin Li, Chun-Xia Zhao, He Wu, Wei Dai, Kai-Nan Wu, Ling-Quan Kong
Neoadjuvant chemotherapy remains an inseparable part of systemic therapy for hormone receptor positive (HR+) advanced breast cancer. However, efficacy of neoadjuvant chemotherapy in this subtype of patients is inferior to its hormone receptor negative counterpart. Several preclinical and clinical studies have suggested that it was growth rate rather than hormone receptor status that determined sensitivity to chemotherapy. In addition, estrogen was proved to recruit more HR+ breast cancer cells into actively dividing phase according to various studies...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28469407/analytical-method-validation-of-high-performance-liquid-chromatography-and-stability-indicating-study-of-medroxyprogesterone-acetate-intravaginal-sponges
#17
Nidal Batrawi, Shorouq Wahdan, Murad Abualhasan
Medroxyprogesterone acetate is widely used in veterinary medicine as intravaginal dosage for the synchronization of breeding cycle in ewes and goats. The main goal of this study was to develop reverse-phase high-performance liquid chromatography method for the quantification of medroxyprogesterone acetate in veterinary vaginal sponges. A single high-performance liquid chromatography/UV isocratic run was used for the analytical assay of the active ingredient medroxyprogesterone. The chromatographic system consisted of a reverse-phase C18 column as the stationary phase and a mixture of 60% acetonitrile and 40% potassium dihydrogen phosphate buffer as the mobile phase; the pH was adjusted to 5...
2017: Analytical Chemistry Insights
https://www.readbyqxmd.com/read/28463398/using-funseq2-for-coding-and-non-coding-variant-annotation-and-prioritization
#18
Priyanka Dhingra, Yao Fu, Mark Gerstein, Ekta Khurana
The identification of non-coding drivers remains a challenge and bottleneck for the use of whole-genome sequencing in the clinic. FunSeq2 is a computational tool for annotation and prioritization of somatic mutations in coding and non-coding regions. It integrates a data context made from large-scale genomic datasets and uses a high-throughput variant prioritization pipeline. This unit provides guidelines for installing and running FunSeq2 to (a) annotate and prioritize variants, (b) incorporate user-defined annotations, and (c) detect differential gene expression...
May 2, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28455279/engaging-patients-and-caregivers-managing-rare-diseases-to-improve-the-methods-of-clinical-guideline-development-a-research-protocol
#19
Dmitry Khodyakov, Kathi Kinnett, Sean Grant, Ann Lucas, Ann Martin, Brian Denger, Holly Peay, Ian Coulter, Arlene Fink
BACKGROUND: Clinical guidelines provide systematically developed recommendations for deciding on appropriate health care options for specific conditions and clinical circumstances. Up until recently, patients and caregivers have rarely been included in the process of developing care guidelines. OBJECTIVE: This project will develop and test a new online method for including patients and their caregivers in this process using Duchenne muscular dystrophy (DMD) care guidelines as an example...
April 28, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28445850/simultaneous-quantification-of-busulfan-clofarabine-and-f-ara-a-using-isotope-labelled-standards-and-standard-addition-in-plasma-by-lc-ms-ms-for-exposure-monitoring-in-hematopoietic-cell-transplantation-conditioning
#20
Arjen M Punt, Jurgen B Langenhorst, Annelies C Egas, Jaap Jan Boelens, Charlotte van Kesteren, Erik M van Maarseveen
In allogeneic hematopoietic cell transplantation (HCT) it has been shown that over- or underexposure to conditioning agents have an impact on patient outcomes. Conditioning regimens combining busulfan (Bu) and fludarabine (Flu) with or without clofarabine (Clo) are gaining interest worldwide in HCT. To evaluate and possibly adjust full conditioning exposure a simultaneous analysis of Bu, F-ARA-A (active metabolite of Flu) and Clo in one analytical run would be of great interest. However, this is a chromatographical challenge due to the large structural differences of Bu compared to F-ARA-A and Clo...
April 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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