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https://www.readbyqxmd.com/read/28445850/simultaneous-quantification-of-busulfan-clofarabine-and-f-ara-a-using-isotope-labelled-standards-and-standard-addition-in-plasma-by-lc-ms-ms-for-exposure-monitoring-in-hematopoietic-cell-transplantation-conditioning
#1
Arjen M Punt, Jurgen B Langenhorst, Annelies C Egas, Jaap Jan Boelens, Charlotte van Kesteren, Erik M van Maarseveen
In allogeneic hematopoietic cell transplantation (HCT) it has been shown that over- or underexposure to conditioning agents have an impact on patient outcomes. Conditioning regimens combining busulfan (Bu) and fludarabine (Flu) with or without clofarabine (Clo) are gaining interest worldwide in HCT. To evaluate and possibly adjust full conditioning exposure a simultaneous analysis of Bu, F-ARA-A (active metabolite of Flu) and Clo in one analytical run would be of great interest. However, this is a chromatographical challenge due to the large structural differences of Bu compared to F-ARA-A and Clo...
April 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28443654/quantifying-the-self-assembly-behavior-of-anisotropic-nanoparticles-using-liquid-phase-transmission-electron-microscopy
#2
Binbin Luo, John W Smith, Zihao Ou, Qian Chen
For decades, one of the overarching objectives of self-assembly science has been to define the rules necessary to build functional, artificial materials with rich and adaptive phase behavior from the bottom-up. To this end, the computational and experimental efforts of chemists, physicists, materials scientists, and biologists alike have built a body of knowledge that spans both disciplines and length scales. Indeed, today control of self-assembly is extending even to supramolecular and molecular levels, where crystal engineering and design of porous materials are becoming exciting areas of exploration...
April 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28435099/a-meta-analysis-but-not-a-systematic-review-an-evaluation-of-the-global-bmi-mortality-collaboration
#3
Katherine M Flegal, John P A Ioannidis
Meta-analyses of individual participant data (MIPDs) offer many advantages and are considered the highest level of evidence. However, MIPDs can be seriously compromised when they are not solidly founded upon a systematic review. These data-intensive collaborative projects may be led by experts who already have deep knowledge of the literature in the field and of the results of published studies and how these results vary based on different analytical approaches. If investigators tailor the searches, eligibility criteria and analysis plan of the MIPD, they run the risk of reaching foregone conclusions...
April 20, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28423454/uk-neqas-survey-of-allergen-component-testing-across-the-united-kingdom-and-other-european-countries
#4
R Saleem, C Keymer, D Patel, W Egner, A W Rowbottom
The clinical utility of molecular diagnostic approaches in allergy investigation is being recognized increasingly to play a significant role in the management of allergic patients. Determining the sensitization pattern, which is best achieved through the use of component resolved diagnostics (CRD), allows effective risk stratification, appropriate treatment and patient selection for immunotherapy. In order to assess the diagnostic service provisions for in-vitro allergy testing across Europe, a survey was carried out via the total immunoglobulin (Ig)E and specific IgE external quality assurance schemes run by UK National External Quality Assessment Service (NEQAS) Immunology, Immunochemistry and Allergy...
April 19, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28417905/analytical-criticalities-associated-to-different-immunological-methods-for-serum-free-light-chain-detection-in-plasma-cell-dyscrasias-a-description-of-particular-clinical-cases
#5
Rocco Sabatino, Antonio Perrone, Marco Cuomo, Sandra Liotti, Vittoria Barchiesi, Monica Cantile, Ernesta Cavalcanti
Current criteria for differential diagnosis of multiple myeloma (MM), Monoclonal gammopathy of undetermined significance (MGUS), and smoldering multiple myeloma (SMM) are included in the 2003 guidelines by the International Myeloma Working Group (IMWG). An updated version was then published in 2014, highlighting the importance of serum free light chain (sFLC) detection, as well as the κ/λ ratio as excellent indicators of clonality. At present, two commercial assays for sFLC quantification are available: the Freelite™ assay and the N-Latex assay...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416965/a-crisis-of-protection-and-safe-passage-violence-experienced-by-migrants-refugees-travelling-along-the-western-balkan-corridor-to-northern-europe
#6
Jovana Arsenijević, Erin Schillberg, Aurelie Ponthieu, Lucio Malvisi, Waeil A Elrahman Ahmed, Stefano Argenziano, Federica Zamatto, Simon Burroughs, Natalie Severy, Christophe Hebting, Brice de Vingne, Anthony D Harries, Rony Zachariah
BACKGROUND: Pushed by ongoing conflicts and pulled by the desire for a better life, over one million migrants/refugees transited Balkan countries and arrived in Europe during 2015 and early 2016. To curb this influx, European countries instituted restrictive migration policies often characterized by building of razor-wire border fences and border closures. Among migrants/refugees who received mental health care in Serbia while travelling through Balkan countries to Northern Europe, we assessed the prevalence and patterns of violent events experienced including physical trauma...
2017: Conflict and Health
https://www.readbyqxmd.com/read/28398550/the-influence-of-socioeconomic-status-on-gestational-weight-gain-a-systematic-review
#7
E C O'Brien, G Alberdi, F M McAuliffe
Background: Despite a large number of publications regarding the association between socioeconomic status (SES) and gestational weight gain (GWG), the literature is inconsistent. We conducted a systematic review of current evidence relating to the association between SES and GWG, according to the Institute of Medicine (IOM) 2009 guidelines. Methods: Six electronic databases were searched, with the final search run on first July 2016. The PRISMA Statement guidelines were followed and a modified version of the RTI Item Bank was used to assess risk of bias within studies...
April 7, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28383683/validated-lc-ms-ms-method-for-determination-of-sf0034-in-mice-plasma-application-to-a-pharmacokinetic-study-in-mice
#8
Umesh Todmal, P S Suresh, Mohd Zainuddin, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Gurulingappa Hallur, Sridharan Rajagopal, Sriram Rajagopal, Ramesh Mullangi
A rapid and sensitive assay method has been developed and validated using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode for the estimation of SF0034 in mice plasma. The assay procedure involves a simple protein precipitation of SF0034 and tolbutamide (internal standard, IS) from mice plasma. Chromatographic separation was performed on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid:acetonitrile (10:90, v/v) at a flow rate of 0...
April 5, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28381272/a-higher-effort-based-paradigm-in-physical-activity-and-exercise-for-public-health-making-the-case-for-a-greater-emphasis-on-resistance-training
#9
James Steele, James Fisher, Martin Skivington, Chris Dunn, Josh Arnold, Garry Tew, Alan M Batterham, David Nunan, Jamie M O'Driscoll, Steven Mann, Chris Beedie, Simon Jobson, Dave Smith, Andrew Vigotsky, Stuart Phillips, Paul Estabrooks, Richard Winett
It is well known that physical activity and exercise is associated with a lower risk of a range of morbidities and all-cause mortality. Further, it appears that risk reductions are greater when physical activity and/or exercise is performed at a higher intensity of effort. Why this may be the case is perhaps explained by the accumulating evidence linking physical fitness and performance outcomes (e.g. cardiorespiratory fitness, strength, and muscle mass) also to morbidity and mortality risk. Current guidelines about the performance of moderate/vigorous physical activity using aerobic exercise modes focuses upon the accumulation of a minimum volume of physical activity and/or exercise, and have thus far produced disappointing outcomes...
April 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28376227/simple-and-highly-sensitive-uplc-esi-ms-ms-assay-for-rapid-determination-of-suvorexant-in-plasma
#10
Muzaffar Iqbal, Essam Ezzeldin, Nasr Y Khalil, Sara T A Al-Rashood, Khalid A Al-Rashood
Suvorexant is a dual orexin receptor antagonist, recently approved by USFDA for the treatment of insomnia. It is drug-of-abuse and listed in Schedule IV drug of the Controlled Substances Act. In this study, a simple and highly sensitive UPLC-MS/MS assay was developed and fully validated for the determination of suvorexant in rat plasma. Both suvorexant and internal standard (rivaroxaban; IS) were separated on Aquity BEHTM C18 column after the extraction form plasma using diethyl ether as extracting agent. An isocratic mobile phase, consisting of acetonitrile and 10 mM ammonium acetate in composition ratio of 85:15 was eluted at flow rate of 0...
March 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28376225/assay-development-for-aminoglycosides-by-hplc-with-direct-uv-detection
#11
Bart Blanchaert, Shengyun Huang, Katarzyna Wach, Erwin Adams, Ann Van Schepdael
The absence of UV chromophores in the structure of most aminoglycosides impedes an easy and straightforward development of analytical methods. It was demonstrated that addition of borate to the mobile phase allowed direct detection of aminoglycosides at the lower end of the UV spectrum. Although the borate ion complexes preferably with compounds possessing vicinal diols, the aim of this study was to develop an assay for tobramycin that does not contain vicinal diols in its structure. Amikacin, an aminoglycoside with a broad spectrum, was added to the study for its high therapeutic importance...
March 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28375843/a-new-immunochemistry-platform-for-a-guideline-compliant-cardiac-troponin-t-assay-at-the-point-of-care-proof-of-principle
#12
Eloisa Lopez-Calle, Pamela Espindola, Juergen Spinke, Sascha Lutz, Alfons Nichtl, Armin Tgetgel, Nicolas Herbert, Moritz Marcinowski, Juergen Klepp, Thomas Fischer, Thorsten Brueckner, Christoph Boehm, Thomas Keller
BACKGROUND: A multitude of troponin assays for the point-of-care (POC) have been developed showing a lack of analytical sensitivity and precision. We present a new platform solution for the high-sensitivity detection of cardiac troponin T (cTnT) in a 30 μL whole blood sample with a turnaround time of 11 min. METHODS: The immunoassay was completely run in a ready-to-use plastic disposable, a centrifugal microfluidic disc with fully integrated reagents. After the sample application, the assay was automatically processed by separating the cellular blood components via centrifugation, followed by incubation of a defined volume from the generated plasma with the immunoreagents...
April 4, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28366438/measuring-joint-kinematics-of-treadmill-walking-and-running-comparison-between-an-inertial-sensor-based-system-and-a-camera-based-system
#13
Corina Nüesch, Elena Roos, Geert Pagenstert, Annegret Mündermann
Inertial sensor systems are becoming increasingly popular for gait analysis because their use is simple and time efficient. This study aimed to compare joint kinematics measured by the inertial sensor system RehaGait® with those of an optoelectronic system (Vicon®) for treadmill walking and running. Additionally, the test re-test repeatability of kinematic waveforms and discrete parameters for the RehaGait® was investigated. Twenty healthy runners participated in this study. Inertial sensors and reflective markers (PlugIn Gait) were attached according to respective guidelines...
March 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28364563/changes-in-second-line-regimen-durability-and-continuity-of-care-in-relation-to-national-art-guideline-changes-in-south-africa
#14
Dorina Onoya, Alana T Brennan, Rebecca Berhanu, Liudmyla van der Berg, Thulasizwe Buthelezi, Matthew P Fox
INTRODUCTION: Little is known about the impact of antiretroviral therapy (ART) guideline changes on the durability of second-line ART and continuity of care. This study examines predictors of early drug substitutions and treatment interruptions using a cohort analysis of HIV positive adults switched to second-line ART between January 2004 and September 2013 in Johannesburg, South Africa. METHODS: The main outcomes were having a drug substitution or treatment interruption in the first 24 months on second-line ART...
December 21, 2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28359338/development-of-the-good-health-research-practice-course-ensuring-quality-across-all-health-research-in-humans
#15
Patricia Henley, Varalakshmi Elango, Olaf Horstick, Riris Andono Ahmad, Christine Maure, Pascal Launois, Corinne Merle, Jamila Nabieva, Yodi Mahendradhata
Quality and ethics need to be embedded into all areas of research with human participants. Good Clinical Practice (GCP) guidelines are international ethical and scientific quality standards for designing, conducting, recording and reporting trials involving human participants. Compliance with GCP is expected to provide public assurance that the rights, safety and wellbeing of participants are protected and that the clinical research data are credible. However, whilst GCP guidelines, particularly their principles, are recommended across all research types, it is difficult for non-clinical trial research to fit in with the exacting requirements of GCP...
March 31, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28353650/text-messaging-an-intervention-to-increase-physical-activity-among-african-american-participants-in-a-faith-based-competitive-weight-loss-program
#16
Pamela McCoy, Sophia Leggett, Azad Bhuiyan, David Brown, Patricia Frye, Bryman Williams
African American adults are less likely to meet the recommended physical activity guidelines for aerobic and muscle-strengthening activity than Caucasian adults. The purpose of this study was to assess whether a text message intervention would increase physical activity in this population. This pilot study used a pre-/post-questionnaire non-randomized design. Participants in a faith-based weight loss competition who agreed to participate in the text messaging were assigned to the intervention group (n = 52)...
March 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28352926/the-effect-of-requesting-a-reason-for-non-adherence-to-a-guideline-in-a-long-running-automated-reminder-system-for-ponv-prophylaxis
#17
Fabian O Kooij, Toni Klok, Benedikt Preckel, Markus W Hollmann, Jasper E Kal
BACKGROUND: Automated reminders are employed frequently to improve guideline adherence, but limitations of automated reminders are becoming more apparent. We studied the reasons for non-adherence in the setting of automated reminders to test the hypothesis that a separate request for a reason in itself may further improve guideline adherence. METHODS: In a previously implemented automated reminder system on prophylaxis for postoperative nausea and vomiting (PONV), we included additional automated reminders requesting a reason for non-adherence...
March 29, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28345495/people-with-dementia-as-peer-workers-challenges-and-benefits-a-thematic-analysis-and-nominal-groups-study
#18
Joshua Stott, Joanne Marie Sweeney, Luke Koschalka, Luke O'Connor, Amanda Mwale
BACKGROUND: There are national initiatives to involve service users in service delivery. However, programs employing people with dementia as peer support workers (PSWs) in memory services are in their infancy. This study is the first to explore the challenges and benefits to staff and peers involved in such a program. METHODS: Focus groups, structured based on nominal groups (NG) methodology were run with PSWs and clinical staff from two memory services. In total, there were 12 participants, with three focus groups: PSWs alone (n = 3); staff members alone (n = 6); and PSWs and staff members combined (n = 6)...
March 27, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28345190/new-medicinal-products-for-chronic-heart-failure-advances-in-clinical-trial-design-and-efficacy-assessment
#19
REVIEW
Martin R Cowie, Gerasimos S Filippatos, Maria de Los Angeles Alonso Garcia, Stefan D Anker, Anna Baczynska, Daniel M Bloomfield, Maria Borentain, Karsten Bruins Slot, Maureen Cronin, Pieter A Doevendans, Amany El-Gazayerly, Claudio Gimpelewicz, Narimon Honarpour, Salim Janmohamed, Heidi Janssen, Albert M Kim, Dominik Lautsch, Ian Laws, Martin Lefkowitz, Jose Lopez-Sendon, Alexander R Lyon, Fady I Malik, John J V McMurray, Marco Metra, Santiago Figueroa Perez, Marc A Pfeffer, Stuart J Pocock, Piotr Ponikowski, Krishna Prasad, Isabelle Richard-Lordereau, Lothar Roessig, Giuseppe M C Rosano, Warren Sherman, Wendy Gattis Stough, Karl Swedberg, Benoit Tyl, Faiez Zannad, Caroline Boulton, Pieter De Graeff
Despite the availability of a number of different classes of therapeutic agents with proven efficacy in heart failure, the clinical course of heart failure patients is characterized by a reduction in life expectancy, a progressive decline in health-related quality of life and functional status, as well as a high risk of hospitalization. New approaches are needed to address the unmet medical needs of this patient population. The European Medicines Agency (EMA) is undertaking a revision of its Guideline on Clinical Investigation of Medicinal Products for the Treatment of Chronic Heart Failure...
March 27, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28344747/gastric-peritoneal-carcinomatosis-a-retrospective-review
#20
Hwee Leong Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Su Pin Choo, David Wai-Meng Tai, Clarinda Wei Ling Chua, Matthew Chau Hsien Ng, Khee Chee Soo, Melissa Ching Ching Teo
AIM: To characterize patients with gastric peritoneal carcinomatosis (PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care. METHODS: We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre. RESULTS: We studied a total of 271 patients with a median age of 63...
March 15, 2017: World Journal of Gastrointestinal Oncology
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