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https://www.readbyqxmd.com/read/28810079/lc-esi-ms-ms-determination-of-4-methylpyrazole-in-dog-plasma-and-its-application-to-a-pharmacokinetic-study-in-dogs
#1
Devaraj V Chandrasekhar, Suresh P S, Sreekanth Dittakavi, Rakesh A Hiremath, Ravi Kanth Bhamidipati, Wolfgang Richter, Nuggehally R Srinivas, Ramesh Mullangi
A simple, specific, sensitive and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of 4-methylpyrazole in dog plasma using N-methylnicotinamide-d4 as an internal standard (IS) as per regulatory guideline.s Sample preparation was accomplished through a simple protein precipitation. Chromatographic separation of 4-methylpyrazole and the IS was performed on a monolithic (Chromolith RP-18e) column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (20:80, v/v) at a flow rate of 1...
August 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28809013/a-step-by-step-guide-to-assemble-a-reptilian-genome
#2
Asier Ullate-Agote, Yingguang Frank Chan, Athanasia C Tzika
Multiple technologies and software are now available facilitating the de novo sequencing and assembly of any vertebrate genome. Yet the quality of most available sequenced genomes is substantially poorer than that of the golden standard in the field: the human genome. Here, we present a step-by-step protocol for the successful sequencing and assembly of a high-quality snake genome that can be applied to any other reptilian or avian species. We combine the great sequencing depth and accuracy of short reads with the use of different insert size libraries for extended scaffolding followed by optical mapping...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808509/an-educational-intervention-to-increase-awareness-reduces-unnecessary-laboratory-testing-in-an-internal-medicine-resident-run-clinic
#3
Erika Leung, Shuang Song, Omar Al-Abboud, Shahed Shams, John English, Wisam Naji, Yafei Huang, Leon Robison, Fred Balis, Hameem I Kawsar
At our resident-run clinic in an underserved community, laboratory test costs in 2013 exceeded the government subsidy by $400 000. To optimize limited resources and improve patient care, an education program to reduce testing was implemented. Between November 2014 and January 2015, residents attended lectures on utilization of laboratory testing, focusing on standard practice guidelines, and analyses of unnecessary tests. Multivariate nonparametric statistical methods and subgroup analysis were used to evaluate cost reduction...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28806141/cutaneous-leishmaniasis-in-saudi-arabia-a-comprehensive-overview
#4
Abuzaid A Abuzaid, Abdalmohsin M Abdoon, Mohamed A Aldahan, Abdullah G Alzahrani, Raaft F Alhakeem, Abdullah M Asiri, Mohamed H Alzahrani, Ziad A Memish
Despite the great efforts by health authorities in Kingdom of Saudi Arabia (KSA), Cutaneous Leishmaniasis (CL) continues to be a major public health problem in the country. Many risk factors make KSA prone to outbreaks and epidemics; among these, rapid urbanization and the huge population movement are the most important. The disease is endemic in many parts of KSA, with the majority of cases concentrated in six regions, including Al-Qaseem, Riyadh, Al-Hassa, Aseer, Ha'il, and Al-Madinah. Leishmania major (L...
August 14, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28795404/palliative-drug-treatments-for-breathlessness-in-cystic-fibrosis
#5
REVIEW
Nishant Jaiswal, Meenu Singh, Amit Agarwal, Kiran K Thumburu
BACKGROUND: Cystic fibrosis is a life-limiting autosomal recessive genetic illness. A feeling of shortness of breath is common in cystic fibrosis, especially as the disease progresses. Reversing the underlying cause is the priority when treating breathlessness (dyspnoea), but when it is not feasible, palliation (easing) becomes the primary goal to improve an individual's quality of life. A range of drugs administered by various routes have been used, but no definite guidelines are available...
August 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28792154/proposal-guidelines-for-standardized-operating-procedures-of-brain-autopsy-brain-bank-in-south-korea
#6
Kyung Hwa Lee, Sang Won Seo, Tae Sung Lim, Eun Joo Kim, Byeong Chae Kim, Yeshin Kim, Ho Won Lee, Jae Pil Jeon, Sung Mi Shim, Duk L Na, Gi Yeong Huh, Min Cheol Lee, Yeon Lim Suh
To obtain an in-depth understanding of brain diseases, including neurodegenerative diseases, psychiatric illnesses, and neoplasms, scientific approach and verification using postmortem human brain tissue with or without disease are essential. Compared to other countries that have run brain banks for decades, South Korea has limited experience with brain banking; nationwide brain banks started only recently. The goal of this study is to provide provisional guidelines for brain autopsy for hospitals and institutes that have not accumulated sufficient expertise...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28767620/effects-of-training-and-overtraining-on-intervertebral-disc-proteoglycans
#7
Renato H S Ueta, Victor A F Tarini, Carlos E Franciozi, Marcel J S Tamaoki, Valquíria P Medeiros, Helena B Nader, Flávio Faloppa
STUDY DESIGN: Animal experimental study OBJECTIVE.: Evaluate the effect of physical activity and overtraining condition on glycosaminoglycan concentration on the intervertebral disc (IVD) using a rat running model. SUMMARY OF BACKGROUND DATA: Some guidelines recommend the implementation of a physical exercise program as treatment for low back pain, however cyclic loading impact on the health of the intervertebral disc and whether there is a dose-response relationship is still incompletely understood...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28738623/analysis-of-illegal-peptide-drugs-via-hilic-dad-ms
#8
Steven Janvier, Evelien De Sutter, Evelien Wynendaele, Bart De Spiegeleer, Celine Vanhee, Eric Deconinck
Biopharmaceuticals have established themselves as highly efficient medicines, and are still one of the fastest growing parts of the health-product industry. Unfortunately, the introduction of these promising new drugs went hand in hand with the creation of a black market for illegal and counterfeit biotechnology drugs. Particularly popular are the lyophilised peptides with a molecular weight of less than 5kDa. Most of them are meant for subcutaneous injection and are easily accessible via the internet. In recent years, different methods based on reversed phase liquid chromatography have been developed to detect and quantify these peptides...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738570/determination-of-selected-bisphenols-parabens-and-estrogens-in-human-plasma-using-lc-ms-ms
#9
Lucie Kolatorova Sosvorova, Tereza Chlupacova, Jana Vitku, Martin Vlk, Jiri Heracek, Luboslav Starka, David Saman, Marketa Simkova, Richard Hampl
In this study, a novel liquid chromatography - tandem mass spectrometry method for the simultaneous determination of bisphenols (BPA, BPS, BPF, BPAF), parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben) and estrogens (estrone, estradiol, estriol) in human plasma is presented. Since all analytes possess the phenolic group, dansyl chloride derivatization was applied in order to gain high sensitivity. The method was validated according to FDA guidelines, and all validation requirements were satisfactory...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737294/a-call-to-action-towards-an-evidence-based-approach-to-using-verbal-encouragement-during-maximal-exercise-testing
#10
REVIEW
Adrian W Midgley, David C Marchant, Andrew R Levy
By definition, maximal exercise testing inherently requires participants to give a maximal effort. This is an important practical issue as submaximal efforts can produce invalid test results. Verbal encouragement is commonly used to motivate participants to maintain or increase effort investment during maximal exercise testing. Accordingly, studies have reported significant increases in time to exhaustion of between 8% and 18% during VO2max and multistage shuttle run tests, and a significant 30·5 m mean increase in 6-min walk test distance...
July 24, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28726691/an-exploratory-study-of-the-effects-of-stormwater-pipeline-materials-on-transported-stormwater-quality
#11
Matthias Borris, Heléne Österlund, Jiri Marsalek, Maria Viklander
Implications of three sewer pipe materials (concrete, galvanized corrugated steel, and polyvinyl chloride (PVC)) for stormwater quality were explored in laboratory experiments, in which three types of stormwater, SW1-SW3, were circulated in 0.5 m long sewer pipe sections. SW1 and SW2 represented synthetic rainwater, without and with fine street sediment added (CTSS = 150 mg/L), respectively, and SW3 was actual stormwater with the same sediment addition as SW2. Following 20-min runs, with an equivalent distance of 500 m travelled by water particles, a number of statistically significant changes in the stormwater chemistry were observed: (i) pH of all the simulated stormwaters increased in the concrete pipe (from 7...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28720639/angioedema-spotlight-a-closer-examination-of-sacubitril-valsartan-safety-results
#12
Ryan E Owens, Carrie S Oliphant
Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. While most of the discussion has focused on efficacy, a closer examination of the safety results, particularly the incidence of angioedema during the run-in and double-blind periods, is also warranted. Although no major safety concerns were identified, an angioedema risk comparable to enalapril was found, primarily in the black population...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720177/validation-of-multiresidue-method-for-analysis-of-31-pesticides-in-rice-using-gas-chromatography-tandem-mass-spectrometry
#13
Rahul Mondal, Ramen Kumar Kole, Anjan Bhttacharyya
Five modified QuEChERS were tested for the multiresidue analysis of 31 pesticides in rice. Rice was spiked with mixture solution of pesticides at 10 ng/g. Method selection was based on the LODs (sensitivity) and recovery tests (accuracy) of the pesticides. Analysis was done in GC-tandem MS in multiple reaction monitoring mode with a total run time of approximately 37 min. The selected method was validated after spiking rice at 20 and 100 ng/g in rice. The performance characteristics of the method impacted for all selected pesticides were acceptable according to the guidelines for method validation (recovery of 70-120% with an RSD of <20% and r2 value of ≥0...
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28720174/selective-determination-of-human-growth-hormone-somatropin-in-the-presence-of-its-chemical-degradation-products
#14
Mamdouh R Rezk, Marwa F Mohamed, Faten Abdelaziz Fathalla, Mostafa A Shehata
A rapid and sensitive HPLC method was developed and validated for selective determination of the human growth hormone (hGH) somatropin in the presence of its deamidated and oxidized degradation products. Reversed-phase chromatography with an acetonitrile and ammonium bicarbonate mobile phase in gradient elution mode was used. A short run time of 15 min allowed rapid and cost-effective analysis, with an average retention time of 7.4 min for native hGH, 6.2 min for its deamidated form, and 4.3 and 6 min for its oxidized variants...
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28718189/-health-related-quality-of-life-self-esteem-and-health-behaviour-on-average-6-years-after-an-obesity-outpatient-lifestyle-program
#15
Ingo Menrath, Angelika Gminder, Olaf Hiort, Ute Thyen
Background Multimodal programs focusing on weight reduction are recommended in guidelines for the treatment of obese children. However, studies investigating the effects of such programs over time are still missing; there is especially a lack of studies considering longer periods after treatment. In the present study, adolescents' bodyweight, health-related quality of life (HRQoL), self-esteem and health behavior were assessed before and directly after the treatment as well as 3 years after the treatment. Methods Between 2005 and 2009 84 children and adolescents took part in a 10-month, multimodal training programme...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28717618/plantar-fasciitis-in-athletes-diagnostic-and-treatment-strategies-a-systematic-review
#16
REVIEW
Federica Petraglia, Ileana Ramazzina, Cosimo Costantino
BACKGROUND: Plantar fasciitis (PF) is reported in different sports mainly in running and soccer athletes. Purpose of this study is to conduct a systematic review of published literature concerning the diagnosis and treatment of PF in both recreational and élite athletes. The review was conducted and reported in accordance with the PRISMA statement. METHODS: The following electronic databases were searched: PubMed, Cochrane Library and Scopus. As far as PF diagnosis, we investigated the electronic databases from January 2006 to June 2016, whereas in considering treatments all data in literature were investigated...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28712629/the-prime-diabetes-model-novel-methods-for-estimating-long-term-clinical-and-cost-outcomes-in-type-1-diabetes-mellitus
#17
William J Valentine, Richard F Pollock, Rhodri Saunders, Jay Bae, Kirsi Norrbacka, Kristina Boye
BACKGROUND: Recent publications describing long-term follow-up from landmark trials and diabetes registries represent an opportunity to revisit modeling options in type 1 diabetes mellitus (T1DM). OBJECTIVES: To develop a new product-independent model capable of predicting long-term clinical and cost outcomes. METHODS: After a systematic literature review to identify clinical trial and registry data, a model was developed (the PRIME Diabetes Model) to simulate T1DM progression and complication onset...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28712313/compulsory-military-service-as-a-measure-of-later-physical-and-cognitive-performance-in-male-survivors-of-childhood-cancer
#18
Ritva Ahomäki, Arja Harila-Saari, Kai Parkkola, Jaakko Matomäki, Päivi M Lähteenmäki
BACKGROUND: Compromised physical fitness and cognitive difficulties have been reported as late effects of cancer treatment during childhood. To assess this issue, the military rankings of cancer survivors in medical checkups at call-up, and conscripts' physical and cognitive performance during the first weeks of compulsory military education were compared to those of matched population controls without a history of cancer. MATERIAL AND METHODS: A total of 1680 male patients born between 1960 and 1992 with a malignancy diagnosed before the age of 16 who were alive at the call-up age (18 years) were identified using the Finnish Cancer Registry, and five age, sex and place of residence matched controls for each patient using the Population Register Centre...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28705226/continuous-surveillance-of-a-pregnancy-clinical-guideline-an-early-experience
#19
Laura Martínez García, Hector Pardo-Hernández, Andrea Juliana Sanabria, Pablo Alonso-Coello
BACKGROUND: To date there is no consensus about the optimal strategy for keeping clinical guidelines (CGs) up-to-date. The aims of this study were (1) to develop a continuous surveillance and updating strategy for CGs and (2) to test the strategy in a specific CG. METHODS: The main steps were as follows: (1) recruiting members for the CG Updating Working Group, (2) mapping the CG, (3) identifying new evidence from the CG Updating Working Group, (4) designing and running restricted literature searches, (5) reviewing drugs and medical devices alerts, (6) screening and assessing the new evidence, (7) reviewing and, if necessary, modifying clinical questions and recommendations, and (8) updating the CG document...
July 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28701460/clinician-self-efficacy-in-initiating-discussions-about-gestational-weight-gain
#20
Helena Piccinini-Vallis
OBJECTIVE: To compare prenatal care providers' perceived self-efficacy in starting discussions about gestational weight gain with pregnant women under a variety of conditions of gradated difficulty, when weight gain has been in excess of current guidelines. DESIGN: A 42-item online questionnaire related to the known barriers to and facilitators of having discussions about gestational weight gain. SETTING: Canada. PARTICIPANTS: Prenatal care providers were contacted through the Family Medicine Maternity Care list server of the College of Family Physicians of Canada...
July 2017: Canadian Family Physician Médecin de Famille Canadien
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