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https://www.readbyqxmd.com/read/27911323/short-term-response-is-not-predictive-of%C3%A2-long-term-response-to%C3%A2-acetylcholinesterase-inhibitors-in-old-age-subjects-with-alzheimer-s-disease-a%C3%A2-real-world-study
#1
Virginia Boccardi, Marta Baroni, Nicoletta Smirne, Alessandra Clodomiro, Sara Ercolani, Annalisa Longo, Carmelinda Ruggiero, Amalia C Bruni, Patrizia Mecocci
BACKGROUND: Most of clinical guidelines recommend discontinuing treatment with cholinesterase inhibitors (ChEIs) in patients with Alzheimer's disease (AD) who do not show an initial response to therapy as evaluated with the Mini-Mental State Examination (MMSE) scale. However, understanding the relationship between the initial response to ChEI treatment and the subsequent course of the disease is extremely important in clinical practice, but evidence is limited, particularly in the old-old population...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910085/sprint-fidelis-implantable-cardioverter-defibrillators-lead-patient-management-and-survival-single-center-study
#2
Marcin Grabowski, Jakub Kosma Rokicki, Sylwia Gajda, Łukasz Januszkiewicz, Andrzej Cacko, Przemysław Stolarz, Grzegorz Opolski
BACKGROUND: Over the last several years significant rises in the use of implanted cardioverter-defibrillators (ICD) have also resulted in a number of associated complications. This number includes lead failure. Sprint Fidelis ICD lead (SF) is regarded as a lead with elevated failure risk. Every center acting in accordance with the guidelines should observe patients more thoroughly especially with recalled leads and run a registry of their follow-up. The aim of the present research was to observe patients with SF leads (types 6948, 6949) from a single implantation center...
December 2, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27890023/progressive-muscle-relaxation-as-a-supportive-intervention-for-cancer-patients-undergoing-chemotherapy-a-systematic-review
#3
Panagiotis Pelekasis, Ifigeneia Matsouka, Anna Koumarianou
BACKGROUND: Many cancer patients use a wide variety of techniques to improve their physical and mental well-being, including relaxation therapy and, specifically, Progressive Muscle Relaxation (PMR). However, there is no strong evidence that supports the efficacy of this technique. OBJECTIVE: Our aim was to review the evidence regarding the use of PMR as a supportive intervention for cancer patients undergoing chemotherapeutic treatment. METHOD: Six databases were electronically searched: AMED, the Cochrane Library, MEDLINE, PsychINFO, Scopus, and the Web of Science...
November 28, 2016: Palliative & Supportive Care
https://www.readbyqxmd.com/read/27886944/osteoarthritis-models-for-appropriate-care-across-the-disease-continuum
#4
REVIEW
Kelli D Allen, Peter F Choong, Aileen M Davis, Michelle M Dowsey, Krysia S Dziedzic, Carolyn Emery, David J Hunter, Elena Losina, Alexandra E Page, Ewa M Roos, Søren T Skou, Carina A Thorstensson, Martin van der Esch, Jackie L Whittaker
Osteoarthritis (OA) is a leading cause of pain and disability worldwide. Despite the existence of evidence-based treatments and guidelines, substantial gaps remain in the quality of OA management. There is underutilization of behavioral and rehabilitative strategies to prevent and treat OA as well as a lack of processes to tailor treatment selection according to patient characteristics and preferences. There are emerging efforts in multiple countries to implement models of OA care, particularly focused on improving nonsurgical management...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886526/food-and-beverage-product-reformulation-as-a-corporate-political-strategy
#5
C Scott, B Hawkins, C Knai
Product reformulation- the process of altering a food or beverage product's recipe or composition to improve the product's health profile - is a prominent response to the obesity and noncommunicable disease epidemics in the U.S. To date, reformulation in the U.S. has been largely voluntary and initiated by actors within the food and beverage industry. Similar voluntary efforts by the tobacco and alcohol industry have been considered to be a mechanism of corporate political strategy to shape public health policies and decisions to suit commercial needs...
November 14, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27881279/the-economic-impact-of-cigarette-smoking-on-the-poor-in-jordan
#6
Amjad M Toukan
OBJECTIVES: To examine the expenditure on cigarette smoking in Jordan and compare the costs with potential investments in food and other essential items. METHODS: Review of available statistics and calculations were performed to estimate the economic cost of cigarette smoking in the Hashemite Kingdom of Jordan. Data on tobacco use and on household expenditures were collected from the Hashemite Kingdom of Jordan official databases. Information on the percentage of adult male smokers in each income group was based on cross-sectional data from 804 adult smokers...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27880039/importance-of-external-cause-coding-for-injury-surveillance-lessons-from-assessment-of-overexertion-injuries-among-u-s-army-soldiers-in-2014
#7
Michelle Canham-Chervak, Ryan A Steelman, Anna Schuh, Bruce H Jones
Injuries are a barrier to military medical readiness, and overexertion has historically been a leading mechanism of injury among active duty U.S. Army soldiers. Details are needed to inform prevention planning. The Defense Medical Surveillance System (DMSS) was queried for unique medical encounters among active duty Army soldiers consistent with the military injury definition and assigned an overexertion external cause code (ICD-9: E927.0-E927.9) in 2014 (n=21,891). Most (99.7%) were outpatient visits and 60% were attributed specifically to sudden strenuous movement...
November 2016: MSMR
https://www.readbyqxmd.com/read/27876084/a-trial-to-determine-whether-septic-shock-reversal-is-quicker-in-pediatric-patients-randomized-to-an-early-goal-directed-fluid-sparing-strategy-versus-usual-care-squeeze-study-protocol-for-a-pilot-randomized-controlled-trial
#8
Melissa J Parker, Lehana Thabane, Alison Fox-Robichaud, Patricia Liaw, Karen Choong
BACKGROUND: Current pediatric septic shock resuscitation guidelines from the American College of Critical Care Medicine focus on the early and goal-directed administration of intravascular fluid followed by vasoactive medication infusions for persistent and fluid-refractory shock. However, accumulating adult and pediatric data suggest that excessive fluid administration is associated with worse patient outcomes and even increased risk of death. The optimal amount of intravascular fluid required in early pediatric septic shock resuscitation prior to the initiation of vasoactive support remains unanswered...
November 22, 2016: Trials
https://www.readbyqxmd.com/read/27873285/prescription-drug-use-and-polypharmacy-among-medicaid-enrolled-adults-with-autism-a-retrospective-cross-sectional-analysis
#9
Rini Vohra, Suresh Madhavan, Usha Sambamoorthi, Claire StPeter, Susannah Poe, Nilanjana Dwibedi, Mayank Ajmera
BACKGROUND: A lack of gold standard treatment for autism spectrum disorders (ASD), no clear ASD management guidelines, and lack of evidence-based pharmacological interventions other than aripiprazole and risperidone elevate the risk of off-label prescribing and adverse effects among individuals with ASD, more so among adults. OBJECTIVE: The aim of this study was to identify and compare the types of prescription drug use, rates of polypharmacy, and characteristics associated with polypharmacy among adults with and without ASD in a retrospective cross-sectional analysis of a three-state Medicaid Analytic eXtract database (2000-2008)...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27870471/analytical-evaluation-of-the-adams-%C3%A2-a1c-ha-8180-thalassemia-mode-high-pressure-liquid-chromatography-analyser-for-the-measurement-of-hba2-and-hbf
#10
E Urrechaga
BACKGROUND: ADAMS(™) A1cHA-8180T is a HPLC system; within 3.5 min, it quantifies HbF, HbA2 , and HbA0 and flags abnormal peaks. We evaluate its analytical performance for routine estimation of HbA2 and HbF, and critical tests were performed for identifying β-thalassemia carriers. METHODS: Trueness imprecision, carry over, linearity, and effect of anemia were evaluated according to ICLH, ICLS, or manufacture's guidelines. Comparison (ADAMS(™) A1c HA-8160T) was performed by running 400 samples from healthy subjects, 30 alpha and 80 beta carriers (range: 1...
December 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27852291/shifting-human-resources-for-health-in-the-context-of-art-provision-qualitative-and-quantitative-findings-from-the-lablite-baseline-study
#11
Misheck J Nkhata, Margaret Muzambi, Deborah Ford, Adrienne K Chan, George Abongomera, Harriet Namata, Ivan Mambule, Annabelle South, Paul Revill, Caroline Grundy, Travor Mabugu, Levison Chiwaula, James Hakim, Cissy Kityo, Andrew Reid, Elly Katabira, Sumeet Sodhi, Charles F Gilks, Diana M Gibb, Janet Seeley, Fabian Cataldo
BACKGROUND: Lablite is an implementation project supporting and studying decentralized antiretroviral therapy (ART) rollout to rural communities in Malawi, Uganda and Zimbabwe. Task shifting is one of the strategies to deal with shortage of health care workers (HCWs) in ART provision. Evaluating Human Resources for Health (HRH) optimization is essential for ensuring access to ART. The Lablite project started with a baseline survey whose aim was to describe and compare national and intercountry delivery of ART services including training, use of laboratories and clinical care...
November 16, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27847533/a-multicentre-survey-of-the-condition-of-ultrasound-probes
#12
Nicholas J Dudley, Darren J Woolley
BACKGROUND: The implementation of quality assurance for ultrasound scanners in the United Kingdom is patchy, but government appointed bodies require quality assurance and there are regulatory requirements for maintenance and inspection of equipment. Previous studies have shown high fault rates in ultrasound probes; some of these studies used electronic probe testers, but there is good evidence that over 90% of faults may be detected using simple methods. We aimed to conduct a multicentre survey of the condition of probes, using visual inspection and assessing the in-air reverberation...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27847162/patient-specific-computational-fluid-dynamics-assessment-of-aortic-hemodynamics-in-a-spectrum-of-aortic-valve-pathologies
#13
Pouya Youssefi, Alberto Gomez, Taigang He, Lisa Anderson, Nick Bunce, Rajan Sharma, C Alberto Figueroa, Marjan Jahangiri
OBJECTIVES: The complexity of aortic disease is not fully exposed by aortic dimensions alone, and morbidity or mortality can occur before intervention thresholds are met. Patient-specific computational fluid dynamics (CFD) were used to assess the effect of different aortic valve morphologies on velocity profiles, flow patterns, helicity, wall shear stress (WSS), and oscillatory shear index (OSI) in the thoracic aorta. METHODS: A total of 45 subjects were divided into 5 groups: volunteers, aortic regurgitation-tricuspid aortic valve (AR-TAV), aortic stenosis-tricuspid aortic valve (AS-TAV), aortic stenosis-bicuspid aortic valve right-left cusp fusion (BAV[RL]), and aortic stenosis-right-non cusp fusion (AS-BAV[RN])...
September 23, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27843565/systematic-reviews-causes-of-non-adherence-to-p2y12-inhibitors-in-acute-coronary-syndromes-and-response-to-intervention
#14
Nina Johnston, John Weinman, Lucy Ashworth, Peter Smethurst, Jad El Khoury, Clare Moloney
To understand the factors associated with non-adherence to oral antiplatelet (OAP) therapy in acute coronary syndromes (ACS), and where interventions have modified these factors. Linked systematic reviews were undertaken in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines, using CINAHL Plus, MEDLINE, PsycINFO and PubMed databases. The searches were limited to studies available in English and published from 2000 onwards; last run in June 2015. Review 1: factors...
2016: Open Heart
https://www.readbyqxmd.com/read/27836449/microbial-flora-on-cell-phones-in-an-orthopedic-surgery-room-before-and-after-decontamination
#15
J Murgier, J-F Coste, E Cavaignac, X Bayle-Iniguez, P Chiron, P Bonnevialle, J-M Laffosse
INTRODUCTION: Cell-phones are the typical kind of object brought into the operating room from outside by hospital staff. A great effort is made to reduce the level of potentially contaminating bacteria in the operating room, and introducing these devices may run counter to good practice. The study hypothesis was that cell-phones are colonized by several strains of bacteria and may constitute a source of nosocomial contamination. The main study objective was to screen for bacterial colonies on the surfaces of cell-phones introduced in an orthopedic surgery room...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27836388/plastic-in-patient-study-prospective-audit-of-adherence-to-peripheral-intravenous-cannula-monitoring-and-documentation-guidelines-with-the-aim-of-reducing-future-rates-of-intravenous-cannula-related-complications
#16
Lokesh Yagnik, Angela Graves, Ken Thong
BACKGROUND: Peripheral intravenous cannula (PIVC) insertion is a universal intervention for inpatients and is associated with multiple complications. Effective, simple, reproducible interventions specific to PIVC complication prevention are few and often extrapolated from central venous catheter complication prevention strategies. The objective of this study is to improve compliance with documentation and monitoring PIVC guidelines in the medical ward of a secondary care center. METHODS: This study is a prospective run-in audit of adherence to PIVC documentation and monitoring guidelines between the dates of August 30-November 14, 2014, with data recollection from December 25, 2014-January 30, 2015, after intervention implementation...
November 8, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27830940/challenges-in-implementing-a-biorisk-management-program-at-universitas-indonesia-a-checklist-tool-for-biorisk-management
#17
Aroem Naroeni, Endang Winiati Bachtiar, Fera Ibrahim, Budiman Bela, Yuni Kusminanti, Ike Pujiriani, Fatma Lestari
Rapid development and advancement of bioresearch at a university's laboratories can have both positive and negative implications for public health and the environment. Many research activities in which biological materials have been created, modified, stored, and manipulated require safety procedures to keep the negative effects on humans and the environment as low as possible. The Occupational Health, Safety and Environmental (OHS&E) Department of the University of Indonesia (UI) is trying to increase the awareness and responsibility of its university members and laboratory staffs who work with biohazard materials by creating a biorisk checklist...
November 10, 2016: Health Security
https://www.readbyqxmd.com/read/27812286/development-functioning-and-effectiveness-of-a-preoperative-risk-assessment-clinic
#18
REVIEW
Hassan Tariq, Rafeeq Ahmed, Salil Kulkarni, Sana Hanif, Omesh Toolsie, Hafsa Abbas, Sridhar Chilimuri
Lee first described the concept of preoperative assessment testing (PAT) clinic in 1949. An efficiently run clinic is associated with increased cost-effectiveness by lowering preoperative admission time and thus reducing the length of stay and the associated costs. The setup of the PAT clinic should be based on the needs, culture, and resources of the institution. Various models for the setup of PAT clinic have been described, including the concept of a perioperative surgical home, which is a patient-centered model designed to improve health and the delivery of health care and to reduce the cost of care...
2016: Health Services Insights
https://www.readbyqxmd.com/read/27802918/high-throughput-assay-for-quantification-of-the-plasma-concentrations-of-thiopental-using-automated-solid-phase-extraction-spe-directly-coupled-to-lc-ms-ms-instrumentation
#19
Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T Smith, Sussan Ghassabian
Most previous assays for thiopental are time-consuming due to laborious sample extraction steps prior to analysis using gas chromatography or high pressure liquid chromatography. Here, we describe the first high-throughput liquid chromatography - tandem mass spectrometry (LC-MS/MS) method for quantification of thiopental concentrations in samples of human plasma. Robotic on-line solid phase extraction (SPE) was used to elute the analytes of interest from samples of human plasma (50μL) loaded onto C18 SPE cartridges to which were added aliquots (50μL) of internal standard solution (thiopental-d5 100ng/mL) and 0...
October 27, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27801384/a-review-of-adult-obesity-research-in-malaysia
#20
K G Lim
A literature search of articles as detailed in the paper Bibliography of clinical research in Malaysia: methods and brief results, using the MESH terms Obesity; Obesity, Abdominal; and Overweight; covering the years 2000 till 2015 was undertaken and 265 articles were identified. Serial population studies showed that the prevalence of obesity increased rapidly in Malaysia in the last decade of the twentieth century. This follows the rising availability of food per capita which had been begun two to three decades previously...
June 2016: Medical Journal of Malaysia
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