keyword
MENU ▼
Read by QxMD icon Read
search

Cancer breast cancer oncology

keyword
https://www.readbyqxmd.com/read/29691075/estro-acrop-guideline-interstitial-multi-catheter-breast-brachytherapy-as-accelerated-partial-breast-irradiation-alone-or-as-boost-gec-estro-breast-cancer-working-group-practical-recommendations
#1
Vratislav Strnad, Tibor Major, Csaba Polgar, Michael Lotter, Jose-Luis Guinot, Cristina Gutierrez-Miguelez, Razvan Galalae, Erik Van Limbergen, Benjamin Guix, Peter Niehoff, Kristina Lössl, Jean-Michel Hannoun-Levi
PURPOSE: This consensus statement from the Breast Cancer Working Group of Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) aims at generating practical guidelines for multi-catheter image-guided brachytherapy in the conservative management of breast cancer patients used for either Accelerated Partial Breast Irradiation (APBI) or for a breast boost. METHODS: Recent advances in techniques of multi-catheter brachytherapy were summarized and all the relevant literature was reviewed by a panel of experts...
April 21, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29689598/correlation-between-circulating-cell-free-pik3ca-tumor-dna-levels-and-treatment-response-in-patients-with-pik3ca-mutated-metastatic-breast-cancer
#2
Annette R Kodahl, Sidse Ehmsen, Niels Pallisgaard, Anne Marie B Jylling, Jeanette Dupont Jensen, Anne-Vibeke Laenkholm, Ann S Knoop, Henrik J Ditzel
Liquid biopsies focusing on the analysis of circulating cell-free tumor DNA (ctDNA) may have important clinical implications for personalized medicine, including early detection of cancer, therapeutic guidance and monitoring of recurrence. Mutations in the oncogene, PIK3CA, are frequently observed in breast cancer and have been suggested as a predictive biomarker for PI3K-selective inhibitor treatment. In this study, we analyzed the presence of PIK3CA mutations in formalin-fixed, paraffin-embedded, metastatic tissue and corresponding ctDNA from serum of patients with advanced breast cancer using a highly-sensitive, optimized droplet digital PCR (ddPCR) assay...
April 24, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29688847/the-cosmam-trial-a-prospective-cohort-study-of-quality-of-life-and-cosmetic-outcome-in-patients-undergoing-breast-conserving-surgery
#3
Coriene J L M Catsman, Martinus A Beek, Adri C Voogd, Paul G H Mulder, Ernest J T Luiten
BACKGROUND: Cosmetic result in breast cancer surgery is gaining increased interest. Currently, some 30-40% of the patients treated with breast conserving surgery (BCS) are dissatisfied with their final cosmetic result. In order to prevent disturbing breast deformity oncoplastic surgical techniques have been introduced. The extent of different levels of oncoplastic surgery incorporated in breast conserving surgery and its value with regard to cosmetic outcome, patient satisfaction and quality of life remains to be defined...
April 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29688026/incidental-pulmonary-embolism-in-oncology-patients-with-current-macroscopic-malignancy-incidence-in-different-tumour-type-and-impact-of-delayed-treatment-on-survival-outcome
#4
Maung Maung Myat Moe, Sridhar Redla
OBJECTIVES: To evaluate the incidence and outcome of incidental PE (iPE) in patients with current macroscopic malignancy and delayed anticoagulation due to late reporting of CT scan. METHODS: Reports of CT thorax with iv contrast done on oncology patients between 01.01.15 and 31.12.15 in two district general hospitals in UK were reviewed. Electronic patient records of iPE patients were reviewed for demographic and treatment information. RESULTS: 26 iPEs were reported in 1,604 scans (731 patients), incidence 1...
April 24, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29687878/anthracycline-and-trastuzumab-induced-cardiotoxicity-in-breast-cancer
#5
M A Nicolazzi, A Carnicelli, M Fuorlo, A Scaldaferri, R Masetti, R Landolfi, A M R Favuzzi
OBJECTIVE: Breast cancer is the most common cancer among women. In the last twenty years early diagnosis, neoadjuvant and adjuvant systemic treatment that targeted to specific molecular targets have significantly reduced the mortality from breast cancer. However, the increase in survival has allowed to observe the cardiotoxic effects of anticancer therapy and increased mortality from cardiovascular causes, resulting in a large literature where experts try to identify the correct management of this critical problem...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687541/evaluation-of-recurrence-patterns-and-survival-in-modern-series-of-young-women-with-breast-cancer
#6
Kelsey E Larson, Stephen R Grobmyer, Stephanie A Valente
The data on oncologic outcomes in young women with breast cancer (BC) are dated as it relates to recurrences and mortality. Our goal was to assess these outcomes in a modern series of young women with BC. A retrospective chart review identified women ≤40 years old with stage I-III BC diagnosed from 2006 to 2013 at our institution. Demographics, tumor biology, type of operation, recurrence, and survival were analyzed. Overall, 322 women were identified. Most had ER+(70%) infiltrating ductal tumors (88%) with low stage (42% T1; 41% T2; 56% N0)...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29687530/radiographically-guided-shave-margins-may-reduce-lumpectomy-re-excision-rates
#7
Kelsey E Larson, Priya Jadeja, Alison Marko, Veeraj Jadeja, Debra Pratt
Minimizing margin re-excision optimizes patient care by providing appropriate oncologic resection and reducing costs. This study aims to assess margin positivity rate in two groups: shave margin based on gross specimen (control group, CG) vs shave margin based on intraoperative imaging (radiographic group, RG). A total of 182 patients who underwent lumpectomy for stage O-III breast cancer at a single institution from January 2013 to January 2014 were evaluated. There was statistically significant decrease in margin re-excision rate with intraoperative mammography but not with ultrasound...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29685380/low-levels-of-intra-tumoural-t-cells-in-breast-cancer-identify-clinically-frail-patients-with-shorter-disease-specific-survival
#8
Lisa Speigl, Alexandra Grieb, Nicole Janssen, Sigrid Hatse, Barbara Brouwers, Ann Smeets, Giuseppe Floris, Jithendra Kini Bailur, Cindy Kenis, Patrick Neven, Hans Wildiers, Graham Pawelec, Christopher Shipp
OBJECTIVES: The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survival, and the local tumour immune environment of older patients with breast cancer. MATERIALS AND METHODS: In a cohort of 58 older patients with breast cancer (over 70 years of age), fluorescence microscopy was used to investigate whether levels of intra-tumoural T cells (CD3+) and granulocytic cells (CD15+) could predict patient clinical outcome, and/or whether they correlated with patient physical and mental performance as evaluated by comprehensive geriatric assessment...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29683834/the-effect-of-preoperative-exercise-on-upper-extremity-recovery-following-breast-cancer-surgery-a-systematic-review
#9
Ajax Yang, Jonas Sokolof, Amitabh Gulati
Prehabilitation benefits among patients undergoing various oncological surgeries have been demonstrated. However, the effects of presurgical exercise and fitness on postoperative ipsilateral upper extremity recovery outcomes in patients with breast cancer surgery are less evident. A systematic review was performed to assess the effects of preoperative exercise and fitness on postmastectomy recovery. Systematic literature search was performed in 12 electronic databases. Study eligibility was accessed using the PICOS (Participants, Interventions, Comparison, Outcome and Study Design) criteria...
April 20, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29683125/factors-associated-with-poor-sleep-in-older-women-diagnosed-with-breast-cancer
#10
Janine Overcash, Alai Tan, Keya Patel, Anne M Noonan
OBJECTIVES: To determine the relationship among gait, grip strength, cognition, depression, pain, and fatigue, and to identify which variables are most predictive of poor sleep. SAMPLE & SETTING: 60 women with breast cancer aged 69 years or older who were receiving treatment in the Senior Adult Oncology Program at the James Cancer Hospital at the Ohio State University. METHODS & VARIABLES: The variables were gait and grip strength (functional domains), cognition, depression, pain, and fatigue...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29681426/tumor-inherent-interferons-impact-on-immune-reactivity-and-immunotherapy
#11
Natasha K Brockwell, Belinda S Parker
Immunotherapy has revolutionized cancer treatment, with sustained responses to immune checkpoint inhibitors reported in a number of malignancies. Such therapeutics are now being trialed in aggressive or advanced cancers that are heavily reliant on untargeted therapies, such as triple negative breast cancer. However, responses have been underwhelming to date and are very difficult to predict, leading to an inability to accurately weigh up the benefit-to-risk ratio for their implementation. The tumor immune microenvironment has been closely linked to immunotherapeutic response, with superior responses observed in patients with T cell-inflamed or 'hot' tumors...
April 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29678596/evaluation-of-acute-skin-toxicity-of-breast-radiotherapy-using-thermography-results-of-a-prospective-single-centre-trial
#12
O Maillot, N Leduc, V Atallah, P Escarmant, A Petit, S Belhomme, P Sargos, V Vinh-Hung
PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced dermatitis...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29678525/close-margins-less-than-2-mm-are-not-associated-with-higher-risks-of-10-year-local-recurrence-and-breast-cancer-mortality-compared-with-negative-margins-in-women-treated-with-breast-conserving-therapy
#13
Susan Tyler, Pauline T Truong, Mary Lesperance, Alan Nichol, Chris Baliski, Rebecca Warburton, Scott Tyldesley
PURPOSE: The 2014 Society of Surgical Oncology-American Society for Radiation Oncology consensus suggested "no ink on tumor" is a sufficient surgical margin for invasive breast cancer treated with breast-conserving surgery (BCS). Whether close margins <2 mm are associated with inferior outcomes remains controversial. This study evaluated 10-year outcomes by margin status in a population-based cohort treated with BCS and adjuvant radiation therapy (RT). METHODS AND MATERIALS: The subjects were 10,863 women with invasive cancer categorized as pT1 to T3, any N, and M0 referred from 2001 to 2011, an era in which the institutional policy was to re-excise close or positive margins, except in select cases...
March 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29676957/increasing-information-dissemination-in-cancer-communication-effects-of-using-palliative-supportive-or-hospice-care-terminology
#14
Jessica M Fishman, Patricia Greenberg, Margy Barbieri Bagga, David Casarett, Kathleen Propert
BACKGROUND: When attempting to share information about comfort-oriented care, many use "palliative," "supportive," and "hospice" care terminology interchangeably, but we lack evidence about the effects of using these different terms. OBJECTIVES: This study was designed to test whether the use of "palliative," "supportive," or "hospice" terminology can improve the dissemination of information among breast cancer patients-a large and growing oncology population...
April 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29675616/a-pharmacometric-analysis-of-patient-reported-outcomes-in-breast-cancer-patients-through-item-response-theory
#15
Emilie Schindler, Lena E Friberg, Bertram L Lum, Bei Wang, Angelica Quartino, Chunze Li, Sandhya Girish, Jin Y Jin, Mats O Karlsson
PURPOSE: An item response theory (IRT) pharmacometric framework is presented to characterize Functional Assessment of Cancer Therapy-Breast (FACT-B) data in locally-advanced or metastatic breast cancer patients treated with ado-trastuzumab emtansine (T-DM1) or capecitabine-plus-lapatinib. METHODS: In the IRT model, four latent well-being variables, based on FACT-B general subscales, were used to describe the physical, social/family, emotional and functional well-being...
April 19, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29674800/olanzapine-versus-aprepitant-for-the-prophylaxis-of-chemotherapy-induced-nausea-and-vomiting-in-breast-cancer-patients-receiving-doxorubicin-cyclophosphamide-regimen-a-prospective-nonrandomized-open-label-study
#16
G Shivaprakash, Karthik S Udupa, V Sarayu, Joseph Thomas, Vishal Gupta, L C Pallavi, Sudhakar Pemminati
OBJECTIVE: Despite the guideline-directed therapy, complete absence of nausea was noted only in 33% of breast cancer patients on anthracycline-cyclophosphamide regimen. Hence, we sought to compare the efficacy of aprepitant (APT) versus olanzapine (OLP) in preventing chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients on doxorubicin-cyclophosphamide regimen. PATIENTS AND METHODS: A prospective, open-label, nonrandomized study was conducted at the Department of Oncology...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674173/precision-medicine-with-imprecise-therapy-computational-modeling-for-chemotherapy-in-breast-cancer
#17
REVIEW
Matthew T McKenna, Jared A Weis, Amy Brock, Vito Quaranta, Thomas E Yankeelov
Medical oncology is in need of a mathematical modeling toolkit that can leverage clinically-available measurements to optimize treatment selection and schedules for patients. Just as the therapeutic choice has been optimized to match tumor genetics, the delivery of those therapeutics should be optimized based on patient-specific pharmacokinetic/pharmacodynamic properties. Under the current approach to treatment response planning and assessment, there does not exist an efficient method to consolidate biomarker changes into a holistic understanding of treatment response...
April 16, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#18
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29671138/nipple-sparing-mastectomy-is-not-associated-with-a-delay-of-adjuvant-treatment
#19
Emily L Albright, Mary C Schroeder, Kendra Foster, Sonia L Sugg, Lillian M Erdahl, Ronald J Weigel, Ingrid M Lizarraga
BACKGROUND: High-volume single-institution studies support the oncologic safety of nipple sparing mastectomy (NSM). Concerns remain regarding the increased potential for complications, recurrence, and delays to subsequent adjuvant therapy. A national database was used to examine treatment and outcomes for NSM patients. METHODS: Women undergoing unilateral NSM or skin sparing mastectomy (SSM) for stage 0-4 breast cancer from 2004 to 2013 were identified from the National Cancer Database...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29667385/chance-of-reimbursement-for-add-on-therapies-in-poland-and-in-the-world-review-of-the-reimbursement-recommendations
#20
Ewa Borowiack, Magdalena Marzec, Anna Nowotarska, Joanna Jarosz, Agata Orkisz, Patrycja Prząda-Machno
INTRODUCTION: Oncology drugs combined with standard therapies (so-called add-on therapies, e.g. bevacizumab, palbociclib) often receive negative recommendations regarding the legitimacy of public financing, issued by government agencies responsible for their assessment, i.e. health technology assessment agencies. The aim of the study was to estimate the scale of the problem related to the reimbursement of add-on therapies used in the treatment of breast and genitourinary cancers in Poland and in the world...
2018: Przegla̧d Epidemiologiczny
keyword
keyword
7548
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"