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https://www.readbyqxmd.com/read/29884452/renal-function-and-acute-heart-failure-outcome
#1
REVIEW
Lluís Llauger, Javier Jacob, Òscar Miró
The interaction between acute heart failure (AHF) and renal dysfunction is complex. Several studies have evaluated the prognostic value of this syndrome. The aim of this systematic review, which includes non-selected samples, was to investigate the impact of different renal function variables on the AHF prognosis. The categories included in the studies reviewed included: creatinine, blood urea nitrogen (BUN), the BUN/creatinine quotient, chronic kidney disease, the formula to estimate the glomerular filtration rate, criteria of acute renal injury and new biomarkers of renal damage such as neutrophil gelatinase-associated lipocalin (NGAL and cystatin c)...
June 5, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29845739/hepatorenal-syndrome-in-the-era-of-acute-kidney-injury
#2
Cristina Solé, Elisa Pose, Elsa Solà, Pere Ginès
Acute kidney injury (AKI) is a frequent complication of patients with advanced cirrhosis that it is associated with increased hospital admissions and decreased survival. The definition of AKI in cirrhosis has been recently modified and the new diagnostic criteria are based on small changes of serum creatinine with respect to previous values, occurring within a short period of time. The use of this new definition may lead to an earlier identification of renal impairment and better prognostic stratification. Hepatorenal syndrome (HRS) is a unique form of AKI developing in patients with end-stage liver disease...
May 30, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29797812/plasma-neutrophil-gelatinase-associated-lipocalin-as-a-predictor-of-renal-parenchymal-involvement-in-infants-with-febrile-urinary-tract-infection-a-preliminary-study
#3
Bo Ae Yun, Eun Mi Yang, Chan Jong Kim
BACKGROUND: Urinary tract infection (UTI) is the most common bacterial infection in infants. Renal parenchymal involvement is an important prognostic factor; however, early detection of parenchymal involvement in UTI may be difficult during infancy. This study aimed to assess whether a recently established biomarker of UTI, neutrophil gelatinase-associated lipocalin (NGAL), can serve as a useful marker for the detection of cortical defects (CD) and to determine the appropriate diagnostic cut-off value of NGAL in infants with febrile UTI...
September 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29791495/early-prediction-of-contrast-induced-acute-kidney-injury-by-a-bedside-assessment-of-neutrophil-gelatinase-associated-lipocalin-during-elective-percutaneous-coronary-interventions
#4
Annunziata Nusca, Marco Miglionico, Claudio Proscia, Laura Ragni, Massimiliano Carassiti, Francesca Lassandro Pepe, Germano Di Sciascio
Contrast-induced acute kidney injury (CI-AKI) is a serious complication during percutaneous coronary interventions (PCI). Currently, the diagnosis of CI-AKI relies on serum creatinine (SCr) that is however affected by several limitations potentially leading to delayed or missed diagnoses. In this study we examined the diagnostic accuracy of a "bedside" measurement of plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) in the early detection of CI-AKI in 97 patients undergoing elective PCI. The overall incidence of CI-AKI was 3%...
2018: PloS One
https://www.readbyqxmd.com/read/29683755/n-acetylcysteine-decreases-urinary-level-of-neutrophil-gelatinase-associated-lipocalin-in-deceased-donor-renal-transplant-recipients-a-randomized-clinical-trial
#5
Atieh Modarresi, Mohsen Nafar, Zahra Sahraei, Jamshid Salamzadeh, Samira Chaibakhsh, Shadi Ziaie, Mahmoud Parvin, Yunes Panahi, Behzad Einollahi
CONTEXT: Acute kidney injury (AKI) is a common complication after kidney transplantation (KT), especially in recipients from deceased donors. Urinary neutrophil gelatinase-associated lipocalin (u-NGAL) is an early and sensitive marker of AKI after transplantation. OBJECTIVES: We assessed the renoprotective effect of N-acetylcysteine (NAC) on u-NGAL levels as an early prognostic marker of graft function immediately after transplantation. MATERIALS AND METHODS: A double-blind, randomized, placebo-controlled trial was conducted on 70 deceased-donor KT recipients ( www...
May 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29622507/serum-neutrophil-gelatinase-associated-lipocalin-ngal-concentration-is-independently-associated-with-mortality-in-patients-with-acute-coronary-syndrome
#6
Ståle H Nymo, Marianne Hartford, Thor Ueland, Arne Yndestad, Erik Lorentzen, Katarina Truvé, Thomas Karlsson, Annica Ravn-Fischer, Pål Aukrust, Kenneth Caidahl
BACKGROUND: Circulating neutrophil gelatinase-associated lipocalin (NGAL) concentration increases in cardiovascular disease, but the long-term prognostic value of NGAL concentration has not been evaluated in acute coronary syndrome (ACS). We examined the association between NGAL concentration and prognosis in patients with ACS after non-ST-elevation myocardial infarction (NSTEMI) or STEMI. METHODS AND RESULTS: NGAL concentration was measured in blood from 1121 consecutive ACS patients (30% women, mean age 65 years) on the first morning after admission...
July 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29602632/urinary-biomarkers-of-kidney-tubular-damage-and-risk-of-cardiovascular-disease-and-mortality-in-elders
#7
Vasantha Jotwani, Ronit Katz, Joachim H Ix, Orlando M Gutiérrez, Michael Bennett, Chirag R Parikh, Steven R Cummings, Mark J Sarnak, Michael G Shlipak
RATIONALE & OBJECTIVE: Novel urinary biomarkers have enabled earlier detection of kidney tubular damage, but their prognostic value for adverse cardiovascular outcomes is uncertain. We hypothesized that tubular damage, measured by urine α1 -microglobulin (A1M), amino-terminal propeptide of type III procollagen (PIIINP), and neutrophil gelatinase-associated lipocalin (NGAL), would be associated with higher risks for cardiovascular events and mortality among elders. STUDY DESIGN: Case-cohort study...
March 27, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29533106/association-of-plasma-neutrophil-gelatinase-associated-lipocalin-with-acute-kidney-injury-and-clinical-outcome-in-cardiac-arrest-survivors-depends-on-the-time-of-measurement
#8
Yong Soo Cho, Byung Kook Lee, Dong Hun Lee, Yong Hun Jung, Sung Min Lee, Jung Soo Park, Kyung Woon Jeung
PURPOSE: The optimal timing for measurement of neutrophil gelatinase-associated lipocalin (NGAL) level to predict acute kidney injury (AKI) and prognosis in cardiac arrest (CA) survivors has not been elucidated. We aimed to compare the diagnostic and prognostic performance of NGAL levels after return of spontaneous circulation (ROSC) and at 48 h after CA. METHODS: We included 231 adult cardiac arrest survivors who underwent targeted temperature management between May 2013 and December 2016...
March 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29515302/neutrophil-gelatinase-associated-lipocalin-as-a-predictor-of-early-diabetic-nephropathy-in-type-2-diabetes-mellitus
#9
A Kaul, M R Behera, M K Rai, P Mishra, D S Bhaduaria, S Yadav, V Agarwal, R Karoli, N Prasad, A Gupta, R K Sharma
This study was carried out to look for diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) in early diabetic nephropathy (DN) in type 2 diabetes individuals. NGAL was measured in both urinary and serum sample of 144 type 2 diabetes individuals stratified into three categories based on urinary albumin-creatinine ratio and 54 control populations with estimated glomerular filtration rate >60 mL/min/1.73 m2 and serum creatinine <1.2 mg/dl. The serum NGAL (sNGAL), urine NGAL (uNGAL), and uNGAL/urine creatinine were significantly higher in diabetic individuals than in the control populations with significant difference in between the groups ( P < 0...
January 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29404502/neutrophil-gelatinase-associated-lipocalin-level-is-a-prognostic-factor-for-survival-in-rat-and-human-chronic-liver-diseases
#10
Kyoko Yoshikawa, Motoh Iwasa, Akiko Eguchi, Shinichi Kojima, Naohiko Yoshizawa, Mina Tempaku, Ryosuke Sugimoto, Norihiko Yamamoto, Kazushi Sugimoto, Yoshinao Kobayashi, Hiroshi Hasegawa, Yoshiyuki Takei
Chronic liver disease patients often have complications, such as hepatocellular carcinoma (HCC) and acute bacterial infection. Model for end-stage liver disease and Child-Pugh scores are useful prognostic factors for chronic liver diseases but not for all chronic conditions, such as HCC. Our investigative aim targeted the prognostic abilities of neutrophil gelatinase-associated lipocalin (NGAL) in rat and human chronic liver diseases. Blood NGAL levels were measured by enzyme-linked immunosorbent assay in rats with cirrhosis and 96 patients with chronic liver disease and HCC...
November 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29398132/markers-of-early-progressive-renal-decline-in-type-2-diabetes-suggest-different-implications-for-etiological-studies-and-prognostic-tests-development
#11
Natalia Nowak, Jan Skupien, Adam M Smiles, Masayuki Yamanouchi, Monika A Niewczas, Andrzej T Galecki, Kevin L Duffin, Matthew D Breyer, Nick Pullen, Joseph V Bonventre, Andrzej S Krolewski
To identify determinants of early progressive renal decline in type 2 diabetes a range of markers was studied in 1032 patients enrolled into the 2nd Joslin Kidney Study. eGFR slopes estimated from serial measurements of serum creatinine during 5-12 years of follow-up were used to define early renal decline. At enrollment, all patients had normal eGFR, 58% had normoalbuminuria and 42% had albuminuria. Early renal decline developed in 6% and in 18% patients, respectively. As determinants, we examined baseline values of clinical characteristics, circulating markers: TNFR1, KIM-1, and FGF23, and urinary markers: albumin, KIM-1, NGAL, MCP-1, EGF (all normalized to urinary creatinine) and the ratio of EGF to MCP-1...
May 2018: Kidney International
https://www.readbyqxmd.com/read/29334742/-diagnostic-and-prognostic-biomarkers-in-acute-coronary-syndrome
#12
REVIEW
Petr Kuběna, Jindřich Špinar, Milan Dastych, Petr Lokaj, Jiří Pařenica
Acute myocardial infarction (AMI) is an important cause of mortality and morbidity worldwide. Early diagnostics of this disease helps in the appropriate treatment of patients. Great attention is paid to the diagnostic and risk stratification of patients according to circulating biomarkers. There are a lot of scientific publications describing this topic. The aim of this article is to provide a comprehensive overview of the most important and most examined biomarkers in acute coronary syndrome. Meanwhile troponin takes a fundamental place for AMI diagnostic (mostly the high-sensitive methods) in preference to MB-fraction of creatine kinase and myoglobin...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29317152/predicting-long-term-outcomes-after-cardiac-arrest-by-using-serum-neutrophil-gelatinase-associated-lipocalin
#13
Yu-Ri Park, Joo Suk Oh, Hyunho Jeong, Jungtaek Park, Young Min Oh, Semin Choi, Kyoung Ho Choi
OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by various tissues in pathologic states. Previous studies reported that post-cardiac arrest serum NGAL levels correlate with short-term neurologic outcomes and survival. The aim of this study was to examine the associations between NGAL levels post-cardiac arrest and long-term outcomes and survival. METHODS: This prospective observational study and retrospective review included adult out-of-hospital cardiac arrest survivors who were treated by hypothermia-targeted temperature management...
April 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29288632/association-of-vascular-indices-with-novel-circulating-biomarkers-as-prognostic-factors-for-cardiovascular-complications-in-patients-with-type-2-diabetes-mellitus
#14
Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Sophia Antoniou, Nikolaos Kazakos, Alexandra Margeli, Ioannis Papassotiriou, Agathocles Tsatsoulis, Lampros K Michalis
BACKGROUND: The pathophysiology of atherosclerosis in type 2 diabetes mellitus (T2DM) is multifactorial. The association of vascular indices with circulating biomarkers of inflammation and insulin resistance and their role in the long-term cardiovascular prognosis in T2DM patients were currently investigated. PATIENTS AND METHODS: Patients with T2DM and poor glycemic control without known cardiovascular diseases (n=119) at baseline were enrolled and followed for about 9years...
March 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29131707/plasma-neutrophil-gelatinase-associated-lipocalin-measured-immediately-after-restoration-of-spontaneous-circulation-predicts-acute-kidney-injury-in-cardiac-arrest-survivors-who-underwent-therapeutic-hypothermia
#15
Dong Hun Lee, Byung Kook Lee, Yong Soo Cho, Yong Hun Jung, Sung Min Lee, Jung Soo Park, Kyung Woon Jeung
Early diagnosis of acute kidney injury (AKI) after cardiac arrest (CA) is challenging. We aimed to identify the diagnostic and prognostic performance of neutrophil gelatinase-associated lipocalin (NGAL) for AKI and its clinical outcomes. A retrospective observational study, involving adult comatose CA survivors treated with therapeutic hypothermia between May 2013 and December 2016, was conducted. AKI was classified according to the guidelines of Kidney Disease Improving Global Outcomes. NGAL levels were measured after return of spontaneous circulation (ROSC)...
June 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29023314/renal-dysfunction-and-cirrhosis
#16
François Durand, Jody C Olson, Mitra K Nadim
PURPOSE OF REVIEW: Hepatorenal syndrome (HRS) does not represent the predominant phenotype of acute kidney injury (AKI) in cirrhosis. Early recognition of HRS helps initiate appropriate therapy. The aims of this review are to present redefinition of AKI, to list new biomarkers, to report recent data on vasopressors in HRS and to propose criteria for simultaneous liver and kidney transplantation (SLKT). RECENT FINDINGS: Urine output, which was not part of the definition of AKI might be reconsidered as it has an independent prognostic value...
December 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28969023/pretreatment-serum-lactate-level-as-a-prognostic-biomarker-in-patients-undergoing-supratentorial-primary-brain-tumor-resection
#17
Chung-Chih Shih, Tzong-Shiun Lee, Fon-Yih Tsuang, Pei-Lin Lin, Ya-Jung Cheng, Hsiao-Liang Cheng, Chun-Yu Wu
INTRODUCTION: Malignant primary brain tumors are one of the most aggressive cancers. Pretreatment serum nonneuronal biomarkers closely associated with postoperative outcomes are of high clinical relevance. The present study aimed to identify potential pretreatment serum biomarkers that may influence oncological outcomes in patients with primary brain tumors. METHODS: A total of 74 patients undergoing supratentorial primary brain tumor resection were enrolled. Before tumor resection, serum neuronal biomarkers, namely neuron-specific enolase (NSE), S100β, and glial fibrillary acidic protein (GFAP), and serum nonneuronal biomarkers, namely neutrophil gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), and lactate, were measured and associated postoperative oncological outcomes, including brain tumor grading, progression-free survival (PFS), and overall survival (OS), were compared...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28737526/serial-measurements-of-neutrophil-gelatinase-associated-lipocalin-prognostic-value-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-a-primary-percutaneous-coronary-intervention
#18
Yeong-Min Lim, Jae Youn Moon, Daniel Min, Sang-Hoon Kim, Woo-In Yang, Won-Jang Kim, Jung-Hoon Sung, In Jai Kim, Sang-Wook Lim, Dong-Hun Cha
BACKGROUND: There are no previous data on serial changes in neutrophil gelatinase-associated lipocalin (NGAL) levels in ST-segment elevation myocardial infarction (STEMI) patients before and after a primary percutaneous coronary intervention (pPCI). The aim of the present study was to evaluate the prognostic value of serial NGAL measurements in patients with STEMI treated by pPCI. MATERIALS AND METHODS: We identified 169 STEMI patients who underwent pPCI within 12 h of symptom onset and had plasma NGAL measurements before (pre-NGAL) and 6 h after (post-NGAL) pPCI...
July 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28733549/pretreatment-serum-lactate-level-as-a-prognostic-biomarker-in-patients-undergoing-supratentorial-primary-brain-tumor-resection
#19
Chung-Chih Shih, Tzong-Shiun Lee, Fon-Yih Tsuang, Pei-Lin Lin, Ya-Jung Cheng, Hsiao-Liang Cheng, Chun-Yu Wu
INTRODUCTION: Malignant primary brain tumors are one of the most aggressive cancers. Pretreatment serum nonneuronal biomarkers closely associated with postoperative outcomes are of high clinical relevance. The present study aimed to identify potential pretreatment serum biomarkers that may influence oncological outcomes in patients with primary brain tumors. METHODS: A total of 74 patients undergoing supratentorial primary brain tumor resection were enrolled. Before tumor resection, serum neuronal biomarkers, namely neuron-specific enolase (NSE), S100β, and glial fibrillary acidic protein (GFAP), and serum nonneuronal biomarkers, namely neutrophil gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), and lactate, were measured and associated postoperative oncological outcomes, including brain tumor grading, progression-free survival (PFS), and overall survival (OS), were compared...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28683730/urinalysis-findings-and-urinary-kidney-injury-biomarker-concentrations
#20
MULTICENTER STUDY
Girish N Nadkarni, Steven G Coca, Allison Meisner, Shanti Patel, Kathleen F Kerr, Uptal D Patel, Jay L Koyner, Amit X Garg, Heather Thiessen Philbrook, Charles L Edelstein, Michael Shlipak, Joe El-Khoury, Chirag R Parikh
INTRODUCTION: Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors are associated with urinary biomarker levels. METHODS: We examined 714 adults who underwent cardiac surgery in the TRIBE-AKI cohort that did not experience post-operative clinical AKI (patients with serum creatinine change of ≥ 20% were excluded)...
July 6, 2017: BMC Nephrology
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