Yindan Wang, Wenjun Fan, Guoqing Zhang, Wenjun Fan, Lisha Zhao, Ting Li, Lu Zhang, Tong Hou, Huihua Hong, Zhenqiang You, Qinghua Sun, Ran Li, Cuiqing Liu
Heat exposure induces excessive hyperthermia associated with systemic inflammatory response that leads to multiple organ dysfunction including acute lung injury. However, how heat impairs the lung remains elusive so far. We aimed to explore the underlying mechanism by focusing on leucine-rich repeat kinase 2 (LRRK2), which was associated with lung homeostasis. Both in vivo and in vitro models were induced by heat exposure. Firstly, heat exposure exerted core temperature (Tc) disturbance, pulmonary dysfunction, atelectasis, inflammation, impaired energy metabolism, and reduced surfactant proteins in the lung of mice...
February 28, 2024: Environmental Pollution