Janel Johnson, Coro Paisán-Ruíz, Grisel Lopez, Cynthia Crews, Angela Britton, Roniel Malkani, E Whitney Evans, Aideen McInerney-Leo, Shushant Jain, Robert L Nussbaum, Kelly D Foote, Ronald J Mandel, Anthony Crawley, Sharon Reimsnider, Hubert H Fernandez, Michael S Okun, Katrina Gwinn-Hardy, Andrew B Singleton
BACKGROUND: Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosomal dominant form of parkinsonism. OBJECTIVE: To identify mutations causing Parkinson's disease (PD) in a cohort of North Americans with familial PD. METHODS: We sequenced exons 1-51 of LRRK2 in 79 unrelated North American PD patients reporting a family history of the disease. RESULTS: One patient had a missense mutation (Thr2356Ile) while two others had the common Gly2019Ser mutation...
2007: Neuro-degenerative Diseases