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Tomislav Preveden, Emidio Scarpellini, Natasa Milić, Francesco Luzza, Ludovico Abenavoli
Hepatitis C virus (HCV) infection is a global health problem with 150 million infected people worldwide. Liver can be greatly affected by changes in gut microbiota due to increased intestinal permeability with passage of microbial antigens into the liver through the portal circulation. The concept of 'gut-liver' axis is important to understand the pathophysiology of several liver diseases. Several recent studies also revealed that an altered gut microbiota can be implicated in the pathogenesis of HCV-induced chronic liver disease (CHC)...
September 2017: Expert Review of Gastroenterology & Hepatology
I S Fomenko, O P Korniychuk, A R Hural, R G Shykula, I I Ilkiv, A Ya Sklyarov
Stress and nonsteroidal anti-inflammatory drugs, which act as nonselective inhibitors of cyclooxygenase, are the main factors of ulcerogenesis in digestive system. However, the peculiarities of their combined action upon the status of intestinal microflora and the parameters of NO-synthase system are still poorly understood. In experiments with rats we show that water-restrained stress was accompanied by a considerable increase of iNOS activity and intensity of lipoperoxidation processes. The increase of Escherichia coli content and the decrease in Enterococcus spp...
2015: Fiziolohichnyĭ Zhurnal
Zhiguang Gao, Bomin Guo, Renyuan Gao, Qingchao Zhu, Huanlong Qin
The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly...
2015: Frontiers in Microbiology
L Fernández, R Arroyo, I Espinosa, M Marín, E Jiménez, J M Rodríguez
The use of culture-dependent and -independent techniques to study the human milk microbiota and microbiome has revealed a complex ecosystem with a much greater diversity than previously anticipated. The potential role of the milk microbiome appears to have implications not only for short- and long-term infant health but also for mammary health. In fact, mammary disbiosis, which may be triggered by a variety of host, microbial and medical factors, often leads to acute, subacute or subclinical mastitis, a condition that represents the first medical cause for undesired weaning...
June 1, 2014: Beneficial Microbes
B N Davydov, O A Gavrilova, K E Ratnikov
The parts of pathogenesis gastrointestinal diseases form relationship with changes in oral cavity. High microbial density bacterial community, consisting of conditionally-pathogenic type and occupying oral mucosa and other parts to oral cavity permits the quick development of the different forms of the pathological processes in oral cavity. The Concept preventive and medical action, conducted in oral cavity of children with chronic gastrodyodenitis, includes: undertaking the diagnostics of the change of microbiocenosis, estimations of the factors of local homeostasis with determination degree of the changes of disbiosis, the individual planning and strictly realization pathogenesis motivated complex action on treatment and preventive maintenance, observation with recommended frequency, including all mentioned elements...
2013: Stomatologii︠a︡
O F Rabinovich, E S Abramova
The possibility of examination of oral fluid bacteriocidal activity in complex diagnostics of oral mucosa disbiosis was evaluated. Thirty-seven patients were included in complex clinical and laboratory studies. The patients were divided in two groups: main group (30 patients exhibiting various grades of oral mucosa disbiosis) and control group (7 patients with no signs of oral disbiosis). The oral fluid bacteriocidal activity was examined by means of laser flow cytometry. Study results proved oral fluid bacteriocidal activity increase to correlate with the grade of oral mucosa disbiosis thus confirming the usefulness of the method in complex diagnostics of oral disbiosis...
2012: Stomatologii︠a︡
Abderzak Lettat, Pierre Nozière, Mathieu Silberberg, Diego P Morgavi, Claudette Berger, Cécile Martin
BACKGROUND: Ruminal disbiosis induced by feeding is the cause of ruminal acidosis, a digestive disorder prevalent in high-producing ruminants. Because probiotic microorganisms can modulate the gastrointestinal microbiota, propionibacteria- and lactobacilli-based probiotics were tested for their effectiveness in preventing different forms of acidosis. RESULTS: Lactic acidosis, butyric and propionic subacute ruminal acidosis (SARA) were induced by feed chalenges in three groups of four wethers intraruminally dosed with wheat, corn or beet pulp...
2012: BMC Microbiology
I D Laranskaia, O V Zaĭrat'iants, Kh M Akhrieva, É V Mulukhova
Study of the colon was carried out in patients with cholelithiasis after cholecystectomy. Estimated clinical symptoms, the mucous membrane status by the results of the histological, morphometric methods, computed ploidometry and immunomorphology of colon biopsy specimens. Mucosal atrophy, the buildup of sclerotic processes and proliferative activity of colonocytes was significantly more frequent in patients with cholecystectomy in history, than in patients with cholelithiasis and the control group. Most of the examined patients have disorders of the colon microbiocenosis...
2011: Experimental & Clinical Gastroenterology
O F Rabinovich, I M Rabinovich, E S Abramova
No abstract text is available yet for this article.
2011: Stomatologii︠a︡
M G Romantsov, O V Tikhomirova
Acute viral and bacterial intestinal infections in children provoke the Tn2 immune response, resulting in development of severe and complicated forms of the disease and sustained by the disbiotic disturbances due to unnecessarily prolonged use of antibacterial drugs. Cycloferon, an early inductor of interferon-1 and -2, was shown to be safe and efficient in the complex therapy of the intestinal infections. It promoted generation of the Th2 immune response and decrease of the repeated isolation of the pathogen with normalization of the disease clinical signs...
2010: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
V A Metel'skaia, B A Aleshkin, E A Voropaeva, A V Karaulov, Iu V Nesvizhskiĭ, S S Afanas'ev, N S Matveevskaia, R L Panurina, A M Bichucher, O G Grechishnikova, A L Baĭrakova, Iu N Urban, A V Aleshkin, V V Slobodeniuk, E A Egorova
The study group was comprised of 27 practically healthy children, 51 patients with acute bronchitis, 15 with chronic bronchitis and 11 with pneumonia. It was shown that changes of microbiocoenosis in back of the throat (BOT) were related to increased mucosal contamination with normal microflora and opportunistic microorganisms. The highest degree of contamination was observed in children with acute bronchitis. Normocoenosis was detected only in 13 practically healthy children. The disorders of microbiocoenosis took the form of disbiosis and acute inflammatory processes in patients with acute and chronic bronchitis and pneumonia...
2010: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
S M Lazarev, O V Voronina
The authors present results of investigation of the state of microbiocenosis of the intestine and immune status of organism of 139 patients after emergency operations on the gastro-intestinal tract organs. Disbiosis and reduced indices of the immune system in the postoperative period was a cause of using biocenosis sparing treatment resulting in stabilization of microecology of the gastro-intestinal tract, higher colonization resistance and general reactivity of organism.
2009: Vestnik Khirurgii Imeni I. I. Grekova
A R Mavziutov, K R Bondarenko, V M Bondarenko
Current microbiological data on the vaginal microecology in healthy women and in patients with bacterial vaginosis are presented in the article. Problems of formation of colonization resistance of vaginal microbiocenosis were discussed. Etiologic role of certain microorganisms and their associations in the pathogenesis of bacterial vaginosis was considered. Pathophysiological processes leading to development of vaginal disbiosis, features of local immune status and molecular specificity of intercellular interactions in the development of adaptive immune response were characterized...
November 2007: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Iu V Nesvizhskiĭ, E A Bogdanova, V V Zverev
The modifying effect of Bacillus cereus on intestinal microbiocenosis was investigated in eubiotic and disbiotic female rats. Qualitative and quantitative characteristics of gut and mucosal microflora from different parts of rats' intestine were studied before and after intragastral application of B. cereus suspension. The single application of B. cereus suspension resulted in appearance of this bacterium in feces and in parietal mucin from all parts of the intestine. In eubiotic rats compared with disbiotic, B...
July 2007: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Tatiana Markova, Denis Chuvirov
Frequently ill children (FIC) show persistence of infection in the nasopharynx, disbiosis of intestinal flora, and concomitant and allergic diseases. As per our results, FIC with acute respiratory diseases (ARD) frequency of 6-15 times a year plus chronic infection foci at the age of 2-15 y/o at the remission period have heterogeneous nature of immune system disorders. It depends on the age, frequency of ARD, and chronic infection foci. About 20-50% of children have low number of T cells and 70% of children have high number of activated T cells...
2007: Advances in Experimental Medicine and Biology
A Iu Leonova, E E Romanenko, A P Baturo
Spectrum of microorganisms vegetated in the large bowel of patients with allergic diseases was investigated. The index of constancy C was used for characterization of the microbial population. 80 patients (31 adults and 49 children < 14 years) were examined. Most prominent changes in obligatory and facultative parts of microflora were revealed in children. Serological typing of 108 cultures of enterobacteria isolated in children under examination with disbiosis showed variety of serogroups that can testify to the presence of pathogenic variants...
May 2007: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Iu V Nesvizhskiĭ, E A Bogdanova, V V Zverev, A A Vorob'ev
Comparative study of qualitative and quantitative characteristics of parietal mucin microbiocenosis in rats with alimentary induced disbiosis was performed. It has been shown that disbiosis was associated with changes in parietal microflora which were observed mainly in colon mucosa. Disbiosis in parietal area, in contrast to central area manifested by changes in quantitative characteristics of microbiocenosis. Results of the study allowed to suppose that parietal mucosal microbiocenosis was more stable than gut one and that this stability was determined by endogenous homeostatic factors of the host...
May 2007: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
I Karag'ozov, E Shopova, P Andreeva
The vagina is original biotype with its own ecosystem, according to medical ecology science. This ecosystem has dynamic, but very unstable equilibrium. Disturb equilibrium is known as a disbiosys. It was discussed different components of this ecosystem: morphology of vaginal walls, vaginal liquidity, lacto-acid and residental flora, "invader" microorganisms, vaginal acidity, immune processes. It was shared our own experience with medicine Polygynax, remedy of Laboratoire Innotech International (Paris, France)...
2004: Akusherstvo i Ginekologii︠a︡
O V Kosyns'kyĭ
The results of studying of alimentary canal microbiocenosis in 40 patients with choledocholithiasis are presented. There was determined that the patients with mechanical jaundice had the degree (30%) of disbiosis twice higher then patients without jaundice. The oligomer enteral mixture "Peptamen" (Nestle) was used in the comolex postoperative therapy. The way of correction of disbiosis by enteral tube feeding in patients with choledocholithiasis had allowed to improve the results of surgical treatment by decrease of postoperative complications frequence by 22...
October 2004: Klinichna Khirurhiia
T N Okhremchuk, L N Pogorel'chuk, V I Marievskiĭ
It was shown that the methods of organism infection resistance valuation employment allows to detect easily and quickly the presence or absence of skin and saliva disbiosis and is considered as an important integral indicator of the state of the organism immunological activity. The methods under consideration are effective for swift studying the state of health of different age groups of population with increased sick rate and for revealing risk groups. They also make it possible to estimate the effectiveness of sanitary measures...
November 2003: Mikrobiolohichnyĭ Zhurnal., Mikrobiologichny Zhurnal
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