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Statins cancer chemoprevention

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https://www.readbyqxmd.com/read/27872797/lovastatin-lowers-the-risk-of-breast-cancer-a-population-based-study-using-logistic-regression-with-a-random-effects-model
#1
Rimi Murakami, Chiehfeng Chen, Shu-Yu Lyu, Ching-En Lin, Pei-Chuan Tzeng, Tzu-Feng Wang, Juei-Chin Chang, Ying-Hua Shieh, I-Fan Chen, Shihping Kevin Huang, Hui-Wen Lin
BACKGROUND: Laboratory studies have demonstrated statin-induced apoptosis of cancer cells, including breast cancer cells, and evidence is accumulating on the mechanism of statin-induced apoptosis. However, despite numerous epidemiological studies, no consensus has been reached regarding the relationship between statin use and breast cancer risk. METHODS: This retrospective case-control study enrolled 4332 breast cancer patients and 21,660 age-matched controls registered in the National Health Insurance program of Taiwan, which covers approximately 99% of the population...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27698930/statins-dose-dependently-exert-significant-chemopreventive-effects-against-various-cancers-in-chronic-obstructive-pulmonary-disease-patients-a-population-based-cohort-study
#2
Chun-Chao Chen, Yi-Ping Hsu, Ju-Chi Liu, Pai-Feng Kao, Li-Chin Sung, Chao-Feng Lin, Wen-Rui Hao, Shing-Hwa Liu, Szu-Yuan Wu
PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at health care facilities in Taiwan (n = 116,017) from January 1, 2001, to December 31, 2012, were recruited. Each patient was followed to assess the following protective and risk factors for all cancers: age; sex; comorbidities (diabetes, hypertension, dyslipidemia) and the Charlson comorbidity index [CCI]); urbanization level; monthly income; and nonstatin drug use...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27542242/statins-dose-dependently-exert-a-significant-chemopreventive-effect-on-colon-cancer-in-patients-with-chronic-obstructive-pulmonary-disease-a-population-based-cohort-study
#3
Ju-Chi Liu, Wen-Rui Hao, Yi-Ping Hsu, Li-Chin Sung, Pai-Feng Kao, Chao-Feng Lin, Alexander T H Wu, Kevin Sheng-Po Yuan, Szu-Yuan Wu
PURPOSE: We evaluated the chemopreventive effect of statins on colon cancer in patients with chronic obstructive pulmonary disease (COPD) and identified the statin exerting the strongest chemopreventive effect. METHODS: Using the National Health Insurance Research Database, we identified patients who received a COPD diagnosis in Taiwan between January 1, 2001, and December 31, 2012, and included them in the study cohort. Each patient was followed to assess the colon cancer risk and protective factors...
August 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27528734/prevention-of-colitis-and-colitis-associated-colorectal-cancer-by-a-novel-polypharmacological-histone-deacetylase-inhibitor
#4
Tzu-Tang Wei, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, Ching-Chow Chen
PURPOSE: Colorectal cancer is a worldwide cancer with rising annual incidence. Inflammation is a well-known cause of colorectal cancer carcinogenesis. Metabolic inflammation (metaflammation) and altered gut microbiota (dysbiosis) have contributed to colorectal cancer. Chemoprevention is an important strategy to reduce cancer-related mortality. Recently, various polypharmacologic molecules that dually inhibit histone deacetylases (HDAC) and other therapeutic targets have been developed...
August 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27517752/statins-dose-dependently-exert-a-chemopreventive-effect-against-lung-cancer-in-copd-patients-a-population-based-cohort-study
#5
Ju-Chi Liu, Tsung-Yeh Yang, Yi-Ping Hsu, Wen-Rui Hao, Pai-Feng Kao, Li-Chin Sung, Chun-Chao Chen, Szu-Yuan Wu
PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with increased lung cancer risk. We evaluated the association of statin use with lung cancer risk in COPD patients and identified which statins possess the highest chemopreventive potential. RESULTS: After adjustment for age, sex, CCI, diabetes, hypertension, dyslipidemia, urbanization level, and monthly income according to propensity scores, lung cancer risk in the statin users was lower than that in the statin nonusers (adjusted hazard ratio [aHR] = 0...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27372106/chemoprevention-of-keratinocyte-carcinomas-an-updated-review
#6
Jessica Mounessa, Rosie Qin, Cory A Dunnick, Robert P Dellavalle
A well-established link between ultraviolet exposure and the carcinogenesis of keratinocyte carcinomas exists. Despite increased sun protection efforts, skin cancer remains the most common cancer in the USA. Numerous studies on the topic of chemoprevention investigate alternative topical, oral, and injectable agents to reduce skin cancer incidence in those at risk. Such agents include sunscreen, numerous vitamins and minerals, difluoromethylornithine, non-steroidal anti-inflammatory drugs, various peptides, field therapy, statins, and polyphenols...
July 2, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27326260/effect-of-lipophilic-and-hydrophilic-statins-on-breast-cancer-risk-in-thai-women-a-cross-sectional-study
#7
Thunyarat Anothaisintawee, Umaporn Udomsubpayakul, Mark McEvoy, Panuwat Lerdsitthichai, John Attia, Ammarin Thakkinstian
BACKGROUND: Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophilic and hydrophilic statins on breast cancer risk using a counterfactual framework approach. METHODS: A cross-sectional study of 15,718 women who were screened for breast cancer at Mammographic center, Ramathibodi Hospital, Bangkok, Thailand, was conducted during September 2011 to 2012...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/26943041/systematic-review-with-network-meta-analysis-statins-and-risk-of-hepatocellular-carcinoma
#8
Yao-Yao Zhou, Gui-Qi Zhu, Yue Wang, Ji-Na Zheng, Lu-Yi Ruan, Zhang Cheng, Bin Hu, Shen-Wen Fu, Ming-Hua Zheng
OBJECTIVES: Usage of statins is suggested to decrease the incidence of HCC. When it comes to different statin subtypes, the chemopreventive action remains controversial. We aim to compare the usage of different statins and reduction of HCC risk. METHODS: We searched PubMed, Embase.com and Cochrane Library database up to August 10, 2015. Duplicated or overlapping reports were eliminated. We performed a traditional pair-wise meta-analysis and a Bayesian network meta-analysis to compare different treatments with a random-effects model...
April 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26905907/statin-use-is-associated-with-reduced-risk-of-colorectal-cancer-in-patients-with-inflammatory-bowel-diseases
#9
Ashwin N Ananthakrishnan, Andrew Cagan, Tianxi Cai, Vivian S Gainer, Stanley Y Shaw, Susanne Churchill, Elizabeth W Karlson, Shawn N Murphy, Katherine P Liao, Isaac Kohane
BACKGROUND & AIMS: Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are associated with an increased risk of colorectal cancer (CRC). Chemopreventive strategies have produced weak or inconsistent results. Statins have been associated inversely with sporadic CRC. We examined their role as chemopreventive agents in patients with IBD. METHODS: We collected data from 11,001 patients with IBD receiving care at hospitals in the Greater Boston metropolitan area from 1998 through 2010...
July 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26772891/rates-and-predictors-of-progression-to-esophageal-carcinoma-in-a-large-population-based-barrett-s-esophagus-cohort
#10
Rajesh Krishnamoorthi, Bijan Borah, Herbert Heien, Ananya Das, Amitabh Chak, Prasad G Iyer
BACKGROUND AND AIMS: Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity, and medications in predicting progression in BE. METHODS: BE subjects were identified from the General Practice Research Database using validated diagnostic codes...
July 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26758944/the-mevalonate-pathway-and-innate-immune-hyper-responsiveness-in-the-pathogenesis-of-copd-and-lung-cancer-potential-for-chemoprevention
#11
Robert P Young, Raewyn J Hopkins
Current evidence suggests that persisting and/or exaggerated inflammation in the lungs initiated by smoking, and up-regulated through genetic susceptibility, may result in lung remodelling and impaired repair. The mevalonate pathway, through its modifying effects on innate immune responsiveness, may be involved in these processes providing a plausible pathogenic link between the development of chronic obstructive pulmonary disease (COPD) and lung cancer. The mevalonate pathway, mediates these effects through important intra-cellular signalling molecules called guanine phosphate transferases (GTPases) such as Rho-A...
January 12, 2016: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/26686322/chemoprevention-of-colorectal-neoplasia
#12
Chris Wakeman, Jacqueline Keenan, Jimmy Eteuati, Paul Hollington, Tim Eglinton, Frank Frizelle
BACKGROUND: Colorectal cancer is a common and often fatal malignancy. Currently, the modifications that alter disease outcome include early symptom recognition, population screening as well as improved surgical and adjuvant treatments. Preventative strategies have been limited with little evidence that lifestyle changes significantly alter risk. There is however a growing awareness of a potential role for chemoprevention in some patient groups. This study aimed to review the literature associated with chemoprevention in colorectal cancer...
December 21, 2015: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26603781/long-term-use-of-statins-and-risk-of-renal-cell-carcinoma-a-population-based-case-control-study
#13
Anton Pottegård, Peter Clark, Søren Friis, Jesper Hallas, Lars Lund
BACKGROUND: Use of statins has been suggested to protect against renal cell carcinoma (RCC); however, studies have typically been underpowered, and the results are conflicting. OBJECTIVE: To determine whether the use of statins is associated with a reduced risk of RCC using high-quality registry data. DESIGN, SETTING, AND PARTICIPANTS: We conducted a nationwide case-control study based on all histologically verified cases of RCC in Denmark between 2002 and 2012 (n=4606) matched 1:10 to cancer-free controls...
May 2016: European Urology
https://www.readbyqxmd.com/read/26439380/breast-cancer-prevention-with-anti-estrogens-review-of-the-current-evidence-and-future-directions
#14
Supriya Mallick, Rony Benson, P K Julka
There is a potential for reducing the incidence of breast cancer by modifying or changing the reversible risk factors like dietary modifications, modifications in the sedentary life habits, etc. One of such methods which has gained popularity now is chemoprevention. Many agents have been evaluated in the chemoprevention setting in females with increased risk of breast cancers. Metformin, NSAIDS, Bisphosphonates, and statins were evaluated by various investigators with variable results. One of the agents that have been proven to be beneficial in this setting is the anti-estrogens...
March 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/26189767/postdiagnostic-statin-use-and-the-risk-of-lethal-prostate-cancer-in-the-health-professionals-follow-up-study
#15
MULTICENTER STUDY
June M Chan, Stacey A Kenfield, Alan Paciorek, Elizabeth A Platz, Edward L Giovannucci, Meir J Stampfer
BACKGROUND: Observational studies suggest potential chemopreventive benefits of statins on prostate cancer outcomes, but data on the impact of postdiagnostic use are sparse. METHODS: We examined the association of postdiagnostic statin use and risk of lethal prostate cancer (metastases or prostate cancer death, N = 242) among 3,949 men diagnosed with localized prostate cancer from the Health Professionals Follow-Up Study between 1992 and 2008 and followed through 2010 (33,302 person years)...
October 2015: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/26183052/drugs-with-potential-chemopreventive-properties-in-relation-to-epithelial-ovarian-cancer-a-nationwide-case-control-study
#16
Louise Baandrup
Ovarian cancer has a poor prognosis because the disease in the majority of patients is diagnosed at an advanced stage as a result of nonspecific symptoms and lack of efficient screening methods. Because of the poor prognosis of ovarian cancer and the challenge of early detection of the disease, identification of protective factors is important. It has been suggested that some commonly used drugs may have a protective effect against cancer, including ovarian cancer; however, the literature on chemopreventive measures for ovarian cancer is sparse and the results are inconclusive...
July 2015: Danish Medical Journal
https://www.readbyqxmd.com/read/26052399/prevention-of-hepatocellular-carcinoma-by-correction-of-metabolic-abnormalities-role-of-statins-and-metformin
#17
REVIEW
Javier Ampuero, Manuel Romero-Gomez
Hepatocellular carcinoma is the third leading cause of cancer-related deaths in the world. It is associated with an important mortality rate and the incidence is increasing. Patients showing metabolic syndrome seem to have higher incidence and mortality rates from hepatocellular carcinoma than healthy subjects, especially those with type 2 diabetes mellitus and obesity. Thus, metformin and statins, both to treat features of metabolic syndrome, have been proposed to decrease the risk of hepatocellular carcinoma...
May 18, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/25835331/esophageal-adenocarcinoma-the-influence-of-medications-used-to-treat-comorbidities-on-cancer-prognosis
#18
REVIEW
Aaron P Thrift
Esophageal adenocarcinoma has undergone a continuous rise in incidence since the early 1970s and is the fastest rising cancer among white men in the United States. Epidemiologic studies have demonstrated that medications commonly used to treat multiple chronic conditions (for example, aspirin, non-aspirin nonsteroidal anti-inflammatory drugs, and statins) as well as powerful acid suppressants such as proton pump inhibitors are associated with a reduced risk of esophageal adenocarcinoma. The chemopreventive potential of these classes of medications appears to be especially applicable to persons with Barrett's esophagus, the only known premalignant condition for esophageal adenocarcinoma...
December 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25768976/statins-in-the-chemoprevention-of-colorectal-cancer-in-established-animal-models-of-sporadic-and-colitis-associated-cancer
#19
Emmanouil Pikoulis, Georgios A Margonis, Anastasios Angelou, George C Zografos, Efstathios Antoniou
Despite the availability of effective surveillance for colorectal cancer with colonoscopy, chemoprevention might be an acceptable alternative. Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins have been found to be beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering...
March 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25738368/molecular-mechanism-underlying-the-anticancer-effect-of-simvastatin-on-mda-mb-231-human-breast-cancer-cells
#20
Yuan-Yuan Shen, Yuan Yuan, Ying-Ying Du, Yue-Yin Pan
Breast carcinoma is the leading cause of cancer-associated mortality in female individuals worldwide. Previous studies have investigated the pro-apoptotic and antimetastatic effects of statins, and have demonstrated that simvastatin exhibits antitumor activity and potent chemopreventive effects. However, the mechanism underlying the effects of simvastatin in breast cancer remains to be elucidated. The present study demonstrated that simvastatin inhibited the proliferation of MDA-MB-231 human breast cancer cells in a dose-dependent manner, decreased the protein expression of B cell lymphoma 2 (Bcl-2) and increased the protein expression of Bcl-2-associated X protein in time- and dose-dependent manners...
July 2015: Molecular Medicine Reports
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