Ligia B Schmitd, Hannah Hafner, Ayobami Ward, Elham Asghari Adib, Natalia P Biscola, Rafi Kohen, Manav Patel, Rachel E Williamson, Emily Desai, Julianna Bennett, Grace Saxman, Mitre Athaiya, David Wilborn, Jaisha Shumpert, Xiao-Feng Zhao, Riki Kawaguchi, Daniel H Geschwind, Ahmet Hoke, Peter Shrager, Catherine A Collins, Leif A Havton, Ashley L Kalinski, Roman J Giger
Upon peripheral nervous system (PNS) injury, severed axons undergo rapid SARM1-dependent Wallerian degeneration (WD). In mammals, the role of SARM1 in PNS regeneration, however, is unknown. Here we demonstrate that Sarm1 is not required for injury-induced activation of neuron-intrinsic growth programs or axonal growth into a nerve crush site. However, in the distal nerve, Sarm1 is necessary for the timely induction of the Schwann cell (SC) repair response, nerve inflammation, myelin clearance, and regeneration of sensory and motor axons...
March 8, 2024: bioRxiv