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Crush injury

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https://www.readbyqxmd.com/read/29155782/partial-optic-nerve-transection-in-rats-a-model-established-with-a-new-operative-approach-to-assess-secondary-degeneration-of-retinal-ganglion-cells
#1
Fancheng Yan, Sailiang Guo, Yijie Chai, Lan Zhang, Kegao Liu, Qingjun Lu, Ningli Wang, Shuning Li
Previous studies have shown that the secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. Partial optic nerve transection is considered a useful and reproducible model. Compared with other optic nerve injury models used commonly for assessing secondary degeneration, e.g. complete optic nerve transection and optic nerve crush models, the partial optic nerve transection model is superior as it distinguishes primary from secondary degeneration in situ. Therefore, it serves as an excellent tool for evaluating secondary degeneration...
October 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155777/transurethral-instillation-procedure-in-adult-male-mouse
#2
Sanghee Lee, Alonso Carrasco, Randall B Meacham, Anna P Malykhina
Transurethral instillation can be used to deliver different solutions with active ingredients (e.g., drugs, chemicals, bacteria, and viruses) locally into the urinary bladder to either induce animal models of bladder pathologies or evaluate the effectiveness of intravesical treatments. Most rodent models of lower urinary tract (LUT) pathologies are induced in female mice due to ease of intravesical instillation of the substances via the female urethra. However, due to anatomical differences between the female and male LUT, transurethral instillation in a male mouse has been deemed a very challenging procedure, and it has not been previously described...
November 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29141256/thrombosis-prevention-with-botulinum-toxin-a-after-traumatic-crush-injury-in-a-rat-model
#3
Seyed Esmail Hassanpour, Mohammadreza Tarahomi, Amir Daryani
No abstract text is available yet for this article.
November 15, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29140621/australian-leadership-saving-lives-with-crush-prevention-devices
#4
Melvin L Myers
The burden of injury and death due to quad bike [all-terrain vehicle, or ATV] use cannot be allowed to continue unchecked, and ongoing delay in action may permit to further avoidable tragedies." -Royal Australasian College of Surgeons (2016, p. 13).
January 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29137466/evaluation-of-extremity-injuries-presented-to-emergency-department
#5
Ali Karakus, Guven Kuvandik, Ezgi Atalay
OBJECTIVE: In this study, we aimed to review cases with firearms injury of extremities presented to our hospital. METHODS: After approval by Institutional Board, electronic database was retrospectively screened for firearms injury of extremities between 2012 and 2015. Overall, 600 cases with firearms injury of extremities were included in the study. Cases were assessed for demographic and clinical characteristics, Mangled extremity severity score (MESS), Glasgow Coma Scale (GCS), costs and outcomes...
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29136763/amorphous-solid-dispersions-of-hecogenin-acetate-using-different-polymers-for-enhancement-of-solubility-and-improvement-of-anti-hyperalgesic-effect-in-neuropathic-pain-model-in-mice
#6
Carlos Demócedes Luís de França Almeida Moreira, Jonas Gabriel de Oliveira Pinheiro, Walter Ferreira da Silva-Júnior, Euzébio Guimarães Barbosa, Zênia Maria Maciel Lavra, Erick Willyame Menezes Pereira, Marília Matos Resende, Eduardo Pereira de Azevedo, Lucindo José Quintans-Júnior, Adriano Antunes de Souza Araújo, Jullyana de Souza Siqueira Quintans, Ádley Antonini Neves de Lima
Hecogenin acetate (HA) is an acetylated sapogenin that has shown potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors. However, HA exhibits poor aqueous solubility, which may limit its application. This study aims to develop amorphous solid dispersions (ASD) using five hydrophilic polymers, to characterize them and to evaluate their antihyperalgesic activity. Physicochemical characterization was performed by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and Fourier Transformed Infrared (FTIR) spectroscopy...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29130653/-advances-in-diagnosis-and-treatment-of-posterior-distal-injury-of-pelvic-fracture
#7
REVIEW
Zhen Tan, Guang-Lin Wang
Pelvic fracture is one of the common diseases of traumatic orthopedics. With the increase of accidents such as traffic accidents,high craters and crush injuries in China,the incidence of pelvic fractures is also increasing year by year. Since pelvic bones and the ligament structure are close to neurovascular,cavity organs and the urogenital structure,early diagnosis and treatment of pelvic fractures is essential for preventing early complications and late sequelae. The treatment of pelvic ring injury has been the focus of pelvic fracture treatment,which determines the outcome of treatment...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29127536/correlation-between-microcirculation-and-contrast-enhanced-ultrasonography-after-crush-injury-of-limbs
#8
Chundong Zhang, Xin Wang, Jie Tang
PURPOSE: To explore the microcirculation formation mechanism of contrast-enhanced (CE) ultrasonography imaging performance in rabbits with limb muscle crush injury. METHODS: Seventy-two New Zealand white rabbits were randomly divided into two groups. A limb muscle crush injury model was created by airing a balloon cuff device with a force of 40 kpa. CE ultrasonography parameters were detected in the first group. In vivo microcirculation parameters were detected in the second group...
November 10, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29120004/nerve-traction-injury-after-subacute-revision-external-fixation-of-a-tibial-plateau-fracture
#9
Lauren E Wessel, Alexander B Christ, David Helfet, David S Wellman
Nerve traction injuries are common clinical entities that can be confused with nerve palsies secondary to alternate etiologies. Common mechanisms of nerve injury include direct laceration, crush injury, compression injury, elevated compartment pressures, or traction injury. Traction injuries commonly occur after trauma or aberrant patient positioning; however, traction injury following external fixation for lower extremity injury is rare. This case report describes a 42-year-old man who initially sustained a Schatzker VI tibial plateau fracture that required revision of external fixation for pin-site infection as soft tissues recovered from the initial trauma...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29119332/therapeutic-effect-of-vinorine-on-sciatic-nerve-injured-rat
#10
Dongdong Guo, Xingang Lu, Xiaoli Xu, Haixin Gou, Zhiqian Wang, Yi Cao, Xingjing Luo
Vinorine is a monoterpenoid indole alkaloid, a type of natural alkaloids. Growing reports exhibited the numerous pharmacology activities of vinorine such as anti-inflammation, anti-bacterial and anti-tumor. In this study, the effect of vinorine injection (7.5, 15 and 30 mg/kg) on motor function, sensation and nerve regeneration in sciatic nerve crush injury rat was investigated. The results of behavioral analysis, electrophysiological analysis and muscle histological analysis suggested that vinorine promoted the motor function recovery after sciatic nerve injury...
November 8, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29117831/age-dependent-schwann-cell-phenotype-regulation-following-peripheral-nerve-injury
#11
Wayne A Chen, T David Luo, Jonathan C Barnwell, Thomas L Smith, Zhongyu Li
BACKGROUND: Schwann cells are integral to the regenerative capacity of the peripheral nervous system, which declines after adolescence. The mechanisms underlying this decline are poorly understood. This study sought to compare the protein expression of Notch, c-Jun, and Krox-20 after nerve crush injury in adolescent and young adult rats. We hypothesized that these Schwann cell myelinating regulatory factors are down-regulated after nerve injury in an age-dependent fashion. METHODS: Adolescent (2 months old) and young adult (12 months old) rats (n = 48) underwent sciatic nerve crush injury...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29117830/in-vitro-evaluation-of-human-hand-tendon-ingrowth-into-a-synthetic-scaffold
#12
Shalimar Abdullah, Fadzlina Mohtar, Nordashima Abdul Shukor, Jamari Sapuan
BACKGROUND: Synthetic scaffold has been used for tissue approximation and reconstructing damaged and torn ligaments. This study explores the ability of tendon ingrowth into a synthetic scaffold in vitro, evaluate growth characteristics, morphology and deposition of collagen matrix into a synthetic scaffold. METHODS: Upper limb tendons were harvested with consent from patients with crush injuries and non-replantable amputations. These tendons (both extensor and flexor) measuring 1 cm are sutured to either side of a 0...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29113341/knockout-of-toll-like-receptor-impairs-nerve-regeneration-after-a-crush-injury
#13
Ching-Hua Hsieh, Cheng-Shyuan Rau, Pao-Jen Kuo, Shu-Hsuan Liu, Chia-Jung Wu, Tsu-Hsiang Lu, Yi-Chan Wu, Chia-Wei Lin
Background: Toll-like receptors (TLRs) are involved in the initiation of Schwann cell activation and subsequent recruitment of macrophages for clearance of degenerated myelin and neuronal debris after nerve injury. The present study was designed to investigate the regenerative outcome and expression of myelination-related factors in Tlr-knockout mice following a sciatic nerve crush injury. Materials and methods: A standard sciatic nerve crush injury, induced by applying constant pressure to the nerve with a No...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111855/neuroprotective-effects-of-inhibitors-of-acid-sensing-ion-channels-asics-in-optic-nerve-crush-model-in-rodents
#14
Dorota L Stankowska, Brett H Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas
PURPOSE: The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC). RESULTS: ASIC1 protein was significantly increased in optic nerve extracts at day 7 following ONC in rats. Activated calpain-1 increased at 2 and 7 days following ONC as evidenced by increased degradation of α-fodrin, known substrate of calpain...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29111100/systemic-cell-cycle-activation-is-induced-following-complex-tissue-injury-in-axolotl
#15
Kimberly Johnson, Joel Bateman, Tia DiTommaso, Alan Y Wong, Jessica L Whited
Activation of progenitor cells is crucial to promote tissue repair following injury in adult animals. In the context of successful limb regeneration following amputation, progenitor cells residing within the stump must re-enter the cell cycle to promote regrowth of the missing limb. We demonstrate that in axolotls, amputation is sufficient to induce cell-cycle activation in both the amputated limb and the intact, uninjured contralateral limb. Activated cells were found throughout all major tissue populations of the intact contralateral limb, with internal cellular populations (bone and soft tissue) the most affected...
October 27, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29109239/graded-elevation-of-c-jun-in-schwann-cells-in-vivo-gene-dosage-determines-effects-on-development-re-myelination-tumorigenesis-and-hypomyelination
#16
Shaline V Fazal, Jose A Gomez-Sanchez, Laura J Wagstaff, Nicolo Musner, Georg Otto, Martin Janz, Rhona Mirsky, Kristjan R Jessen
Schwann cell c-Jun is implicated in adaptive and maladaptive functions in peripheral nerves. In injured nerves, this transcription factor promotes the repair Schwann cell phenotype and regeneration, and it promotes Schwann cell mediated neurotrophic support in models of peripheral neuropathies. However, c-Jun is associated with tumour formation in some systems, it potentially supresses myelin genes, and has been implicated in demyelinating neuropathies. To clarify these issues, and determine how c-Jun levels determine its function, we have generated, c-Jun OE/+ and c-Jun OE/OE mice, with graded expression of c-Jun in Schwann cells, and examined these lines during development, in adulthood and after injury using RNA sequencing analysis, quantitative electron microscopic morphometry, Western blotting and functional tests...
November 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29100662/management-of-partial-fingertip-amputation-in-adults-operative-and-non-operative-treatment
#17
REVIEW
Kunal Sindhu, Steven F DeFroda, Andrew P Harris, Joseph A Gil
BACKGROUND: Hand and finger injuries account for approximately 4.8 million visits to emergency departments each year. These injuries can cause a great deal of distress for both patients and providers and are often initially encountered in urgent care clinics, community hospitals, and level one trauma centers. Tip amputation injuries vary widely in mechanism, ranging from sharp lacerations to crush injuries that present with varying degrees of contamination. The severity of damage to soft tissue, bone, arteries and nerves is dependent upon the mechanism and guides treatment decision-making...
October 31, 2017: Injury
https://www.readbyqxmd.com/read/29100176/a-left-thoracic-approach-in-a-prone-position-for-thoracoscopic-thoracic-duct-ligation-in-a-patient-with-post-esophagectomy-chylothorax-a-case-report
#18
Kiyotomi Maruyama, Kou Shimada, Toshikazu Hamanaka, Shinsuke Sugenoya, Kuniyuki Gomi, Motohiro Mihara, Shoji Kajikawa, Yusuke Sato
INTRODUCTION: We debate whether or not to approach from right thorax for the left chylothorax after esophagectomy. PRESENTATION OF CASE: A 50s-year-old female underwent right-sided thoracoscopic esophagectomy with three-field lymphadenectomy for esophageal carcinoma (type 0-IIa, 3.4×2.2cm, T1bN0M0, Stage IA), followed by reconstruction with esophagogastric anastomosis through the posterior mediastinum. The thoracic duct was excised and ligated. The left thoracic drainage increased to 2115mL/day on the fifth postoperative day...
October 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29097415/gadolinium-dtpa-enhancement-characteristics-of-the-rat-sciatic-nerve-after-crush-injury-at-4-7t
#19
B J Hill, K R Padgett, V Kalra, A Marcillo, B Bowen, P Pattany, D Dietrich, R Quencer
BACKGROUND AND PURPOSE: Traumatic peripheral nerve injury is common and results in loss of function and/or neuropathic pain. MR neurography is a well-established technique for evaluating peripheral nerve anatomy and pathology. However, the Gd-DTPA enhancement characteristics of acutely injured peripheral nerves have not been fully examined. This study was performed to determine whether acutely crushed rat sciatic nerves demonstrate Gd-DTPA enhancement and, if so, to evaluate whether enhancement is affected by crush severity...
November 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29090002/adipose-derived-mesenchymal-stem-cells-accelerate-nerve-regeneration-and-functional-recovery-in-a-rat-model-of-recurrent-laryngeal-nerve-injury
#20
Yun Li, Wen Xu, Li-Yu Cheng
Medialization thyroplasty or injection laryngoplasty for unilateral vocal fold paralysis cannot restore mobility of the vocal fold. Recent studies have shown that transplantation of mesenchymal stem cells is effective in the repair of nerve injuries. This study investigated whether adipose-derived stem cell transplantation could repair recurrent laryngeal nerve injury. Rat models of recurrent laryngeal nerve injury were established by crushing with micro forceps. Adipose-derived mesenchymal stem cells (ADSCs; 8 × 10(5)) or differentiated Schwann-like adipose-derived mesenchymal stem cells (dADSCs; 8 × 10(5)) or extracellular matrix were injected at the site of injury...
September 2017: Neural Regeneration Research
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