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https://www.readbyqxmd.com/read/28644934/fingertip-injuries-in-children-epidemiology-financial-burden-and-implications-for-prevention
#1
Rachel R Yorlets, Kathleen Busa, Kyle R Eberlin, Mohammad Ali Raisolsadat, Donald S Bae, Peter M Waters, Brian I Labow, Amir H Taghinia
BACKGROUND: Although fingertip injuries are common, there is limited literature on the epidemiology and hospital charges for fingertip injuries in children. This descriptive study reports the clinical features of and hospital charges for fingertip injuries in a large pediatric population treated at a tertiary medical center. METHODS: Our hospital database was queried using International Classification of Diseases, Revision 9 (ICD-9) codes, and medical records were reviewed...
July 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28640893/oroxylin-a-promotes-retinal-ganglion-cell-survival-in-a-rat-optic-nerve-crush-model
#2
Shu-Fang Lin, Jia-Ying Chien, Kishan Kapupara, Chi-Ying F Huang, Shun-Ping Huang
PURPOSE: To investigate the effect of oroxylin A on the survival of retinal ganglion cells (RGC) and the activation of microglial cells in a rat optic nerve (ON) crush model. METHODS: Oroxylin A (15mg/Kg in 0.2ml phosphate-buffered saline) or phosphate-buffered saline (PBS control) was immediately administered after ON crush once by subcutaneous injection. Rats were euthanized at 2 weeks after the crush injury. The density of RGC was counted by retrograde labeling with FluoroGold and immunostaining of retina flat mounts for Brn3a...
2017: PloS One
https://www.readbyqxmd.com/read/28630841/bipolar-hemiarthroplasty-in-a-patient-with-above-knee-amputation-surgical-technique
#3
Ramesh Perumal, Santhosh Ram Gaddam, J Vasudeva, J Dheenadhayalan, S Rajasekaran
INTRODUCTION: Femoral neck fractures are a common occurrence in lower limb amputees. Good post-operative results of hip hemiarthroplasty have been described in below-knee amputees. However, to our knowledge, very few such cases have been reported in above-knee amputees. CASE REPORT: We present a case of a 75-year-old male patient who underwent above-knee amputation of the right lower limb for severe crush injury right leg and a bipolar hemiarthroplasty for an ipsilateral fracture neck of femur sustained in the same road traffic accident...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28629926/different-functional-susceptibilities-of-mouse-retinal-ganglion-cell-subtypes-to-optic-nerve-crush-injury
#4
Zhen Puyang, Hai-Qing Gong, Shi-Gang He, John B Troy, Xiaorong Liu, Pei-Ji Liang
In optic neuropathies, the progressive deterioration of retinal ganglion cell (RGC) function leads to irreversible vision loss. Increasing experimental evidence suggests differing susceptibility for RGC functional subtypes. Here with multi-electrode array recordings, RGC functional loss was characterized at multiple time points in a mouse model of optic nerve crush. Firing rate, latency of response and receptive field size were analyzed for ON, OFF and ON-OFF RGCs separately. It was observed that responses and receptive fields of OFF cells were impaired earlier than ON cells after the injury...
June 16, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28629517/erythropoietin-mediated-neuroprotection-in-insects-suggests-a-prevertebrate-evolution-of-erythropoietin-like-signaling
#5
Ralf Heinrich, Verena Günther, Natasa Miljus
The cytokine erythropoietin (Epo) mediates protective and regenerative functions in mammalian nervous systems via activation of poorly characterized receptors that differ from the "classical" homodimeric Epo receptor expressed on erythroid progenitor cells. Epo genes have been identified in vertebrate species ranging from human to fish, suggesting that Epo signaling evolved earlier than the vertebrate lineage. Studies on insects (Locusta migratoria, Chorthippus biguttulus, Tribolium castaneum) revealed Epo-mediated neuroprotection and neuroregeneration...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28626389/rac1-guides-porf-2-to-wnt-pathway-to-mediate-neural-stem-cell-proliferation
#6
Xi-Tao Yang, Guo-Hui Huang, Hong-Jiang Li, Zhao-Liang Sun, Nan-Jie Xu, Dong-Fu Feng
The molecular and cellular mechanisms underlying the anti-proliferative effects of preoptic regulator factor 2 (Porf-2) on neural stem cells (NSCs) remain largely unknown. Here, we found that Porf-2 inhibits the activity of ras-related C3 botulinum toxin substrate 1 (Rac1) protein in hippocampus-derived rat NSCs. Reduced Rac1 activity impaired the nuclear translocation of β-catenin, ultimately causing a repression of NSCs proliferation. Porf-2 knockdown enhanced NSCs proliferation but not in the presence of small molecule inhibitors of Rac1 or Wnt...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28620418/the-changes-in-rats-with-sciatic-nerve-crush-injury-supplemented-with-evening-primrose-oil-behavioural-morphologic-and-morphometric-analysis
#7
Danial Ramli, Izzuddin Aziz, Masro Mohamad, Dauda Abdulahi, Junedah Sanusi
Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. As evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid, studies have shown the potential role of EPO in myelination. Seventy-two healthy adult Sprague-Dawley rats were classified into three groups: normal group, control group, and experimental group. The result indicates that there was significant difference in toe-spreading reflex between the normal and the control groups (1...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28616231/lymph-node-transfer-for-refractory-infectious-sites-caused-by-trauma
#8
Makoto Mihara, Hisako Hara, Kazuki Kikuchi
OBJECTIVE: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection. CASE AND RESULTS: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. After conservative treatment, we transferred a lymph-node-containing free superficial circumflex iliac artery perforator flap to the region, with minimum debridement...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28611170/go-karting-injury-a-case-of-laryngeal-trauma
#9
Marina Brimioulle, Matthew King, Philippe Bowles, Nicholas Saunders
We report a case of accidental strangulation and crush injury to the anterior neck resulting in laryngeal trauma. This extremely uncommon mechanism of injury provides a safety warning regarding precautions with neck wear, and the unusual resulting injury represents an opportunity to review best practice in management of laryngeal trauma.
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28603016/rapid-repeatable-in%C3%A2-vivo-detection-of-retinal-reactive-oxygen-species
#10
Ning Fan, Sean M Silverman, Yang Liu, Xizhen Wang, Byung-Jin Kim, Liping Tang, Abbot F Clark, Xuyang Liu, Iok-Hou Pang
Oxidative injuries, such as those related to reactive oxygen species (ROS), have been implicated in various retinal and optic nerve disorders. Many ROS detection methods have been developed. Although widely utilized, many of these methods are useful only in post mortem tissues, or require relatively expensive equipment, or involve intraocular injection. In the present study, we demonstrated and characterized a chemiluminescent probe L-012 as a noninvasive, in vivo ROS detection agent in the mouse retina. Using optic nerve crush (ONC) and retinal ischemia/reperfusion (I/R) as injury models, we show that L-012 produced intensive luminescent signals specifically in the injured eyes...
June 8, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28599231/open-and-contaminated-pediatric-pelvic-ring-injury-case-report-fixation-without-metal
#11
Brian R Dilworth, John T Riehl
INTRODUCTION: Pelvic fractures are relatively uncommon in children, accounting for 0.3-7.5% of all pediatric injuries (Gänsslen et al., 2013; Ismail et al., 1996; Peltier, 1965; Galano et al., 2005; Spiguel et al., 2006). This case report describes a pediatric open pelvic injury caused by a crush mechanism between a car and guardrail. CASE: A 13year old male presented with an open APC 3 pelvic injury after being pinned between a car and guardrail. His definitive treatment included bilateral SI screw placement, as well as a less invasive method for anterior pelvic ring disruption (Internal Brace suture anchor dynamic fixation)...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28594518/pediatric-phalanx-fractures
#12
Joshua M Abzug, Karan Dua, Andrea Sesko Bauer, Roger Cornwall, Theresa O Wyrick
Phalangeal fractures are the most common type of hand fracture that occurs in the pediatric population and account for the second highest number of emergency department visits in the United States for fractures. The incidence of phalangeal fractures is the highest in children aged 10 to 14 years, which coincides with the time that most children begin playing contact sports. Younger children are more likely to sustain a phalangeal fracture in the home setting as a result of crush and laceration injuries. Salter-Harris type II fractures of the proximal phalanx are the most common type of finger fracture...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28587982/the-histological-effects-of-ozone-therapy-on-sciatic-nerve-crush-injury-in-rats
#13
Hakan Somay, Selin Tural Emon, Serap Uslu, Metin Orakdogen, Zeynep Cingu Meric, Umit Ince, Tayfun Hakan
No abstract text is available yet for this article.
June 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28579157/compound-mechanism-of-fatal-neck-injury-a-case-report-of-a-tiger-attack-in-a-zoo
#14
Łukasz Szleszkowski, Agata Thannhäuser, Tomasz Jurek
Fatal injuries caused by attacks by large wild cats are extremely rare in forensic medical practice in Europe. There are very few cases described in the forensic medical literature concerning incidents in zoos similar to the tiger attack on a 58-year-old male zoo employee that we present here. While preparing a runway for tigers, the man was attacked by a male Sumatran tiger. Another zoo employee was an eyewitness to the accident; in his testimony he described the sequence of events in detail. The autopsy showed the injuries typical of a tiger attack: traces of claws and canine teeth indicating that the victim of the attack was knocked down from behind, along with deep and extensive fatal wounds to the neck...
May 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28574939/management-of-tarsometatarsal-joint-injuries
#15
Brian M Weatherford, John G Anderson, Donald R Bohay
Joint disruptions to the tarsometatarsal (TMT) joint complex, also known as the Lisfranc joint, represent a broad spectrum of pathology from subtle athletic sprains to severe crush injuries. Although injuries to the TMT joint complex are uncommon, when missed, they may lead to pain and dysfunction secondary to posttraumatic arthritis and arch collapse. An understanding of the appropriate anatomy, mechanism, physical examination, and imaging techniques is necessary to diagnose and treat injuries of the TMT joints...
June 1, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28566784/management-of-open-fractures-using-a-noncontact-locking-plate-as-an-internal-fixator
#16
Azad Yıldırım, Ahmet Kapukaya, Yılmaz Mertsoy, Şehmus Yiğit, Mehmet Akif Çaçan, Ramazan Atiç
BACKGROUND: The treatment of open fractures leads to major problems which may be due to various reasons. It mainly causes soft tissue problems due to the absorption of a large amount of energy by the soft tissues and bone tissues. Although some recent treatment protocols have eliminated many problems regarding delayed soft tissue closure, it still remains a big challange. This study uses a method called the internal fixator technique with noncontact locking plate (NC-LP) which involves the use of a combination of advantages of open and closed fixation techniques...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28554806/blockade-of-atp-p2x7-receptor-enhances-ischiatic-nerve-regeneration-in-mice-following-a-crush-injury
#17
Tatianne Ribeiro, Júlia Teixeira Oliveira, Fernanda Martins Almeida, Marcelo Amorim Tomaz, Paulo A Melo, Suelen Adriani Marques, Geanne Matos de Andrade, Ana Maria Blanco Martinez
Preventing damage caused by nerve degeneration is a great challenge. There is a growing body of evidence implicating extracellular nucleotides and their P2 receptors in many pathophysiological mechanisms. In this work we aimed to investigate the effects of the administration of Brilliant Blue G (BBG) and Pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid (PPADS), P2X7 and P2 non-selective receptor antagonists, respectively, on sciatic nerve regeneration. Four groups of mice that underwent nerve crush lesion were used: two control groups treated with vehicle (saline), a group treated with BBG and a group treated with PPADS during 28 days...
May 26, 2017: Brain Research
https://www.readbyqxmd.com/read/28553345/recombinant-human-fibroblast-growth-factor-2-promotes-nerve-regeneration-and-functional-recovery-after-mental-nerve-crush-injury
#18
Sung Ho Lee, Wei-Peng Jin, Na Ri Seo, Kang-Mi Pang, Bongju Kim, Soung-Min Kim, Jong-Ho Lee
Several studies have shown that fibroblast growth factor-2 (FGF2) can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 (rhFGF2) treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 μg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score...
April 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28544161/bone-marrow-derived-cells-response-in-proximal-regions-of-nerves-after-peripheral-nerve-injury
#19
Lulu Chen, Jia Cheng, Xiaonan Yang, Xiaolei Jin, Zuoliang Qi, Yu-Qing Jin
In recent years, bone marrow-derived cells have been found to be crucial for peripheral nerve regeneration. After traumatic peripheral nerve injury, bone marrow-derived macrophages quickly infiltrate into the distal regions of nerves. To explore the changes caused by bone marrow-derived cells within the proximal regions of the nerves, sciatic nerves of chimeric mice carrying bone marrow cells expressing green fluorescent protein were crushed to observe the infiltration of invading bone marrow-derived cells...
May 24, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28539419/microglia-are-irrelevant-for-neuronal-degeneration-and-axon-regeneration-after-acute-injury
#20
Alexander M Hilla, Heike Diekmann, Dietmar Fischer
The role of microglia in de- and regenerative processes after damage of the nervous system still remains ambiguous, partially due to the paucity of appropriate investigative methods. Here, we show that treatment with the pharmacological colony stimulating factor 1 receptor inhibitor PLX5622 specifically eliminated microglia in murine retinae and optic nerves. Interestingly, time course and extent of retinal ganglion cell (RGC) degeneration after optic nerve crush remained unaffected upon microglia depletion, although remnants of pre-labeled apoptotic RGCs were not cleared from the retina in these animals...
May 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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