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https://www.readbyqxmd.com/read/27931509/transplantation-of-human-urine-derived-stem-cells-transfected-with-pigment-epithelium-derived-factor-to-protect-erectile-function-in-a-rat-model-of-cavernous-nerve-injury
#1
Qiyun Yang, Xin Chen, Tao Zheng, Dayu Han, Heng Zhang, Yanan Shi, Jun Bian, Xiangzhou Sun, Kai Xia, Xiaoyan Liang, Guihua Liu, Yuanyuan Zhang, Chunhua Deng
The aim of this study was to investigate whether intracavernous injection of urine-derived stem cells (USCs) or USCs genetically modified with pigment epithelium-derived factor (PEDF) could protect the erectile function and cavernous structure in a bilateral cavernous nerve injury-induced erectile dysfunction (CNIED) rat model. USCs were cultured from the urine of six healthy male donors. Seventy-five rats were randomly divided into five groups (n=15 per group): sham, bilateral cavernous nerve (CN) crush injury (BCNI), USC, USCGFP+, and USCGFP/PEDF+ groups...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27927955/gpr126-adgrg6-has-schwann-cell-autonomous-and-nonautonomous-functions-in-peripheral-nerve-injury-and-repair
#2
Amit Mogha, Breanne L Harty, Dan Carlin, Jessica Joseph, Nicholas E Sanchez, Ueli Suter, Xianhua Piao, Valeria Cavalli, Kelly R Monk
: Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27920043/a-historical-perspective-on-crush-syndrome-the-clinical-application-of-its-pathogenesis-established-by-the-study-of-wartime-crush-injuries
#3
REVIEW
Dilini Peiris
Crush syndrome is a fine example of how pathology can play a direct role in revealing the best treatment and management for diseases. It can occur when crush injuries are sustained. Skeletal muscle becomes damaged under the weight of a heavy object, and victims experience severe shock and renal failure. The discovery of the pathology of crush syndrome belongs to two individuals: Seigo Minami and Eric Bywaters. They separately helped to define the pathogenesis of crush syndrome during World Wars I and II. Seigo Minami is believed to have been the first to record the pathogenesis of crush syndrome...
December 5, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27904500/electrical-stimulation-promotes-regeneration-of-injured-oculomotor-nerves-in-dogs
#4
Lei Du, Min Yang, Liang Wan, Xu-Hui Wang, Shi-Ting Li
Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the right oculomotor nerves of adult dogs. Stimulating electrodes were positioned in both proximal and distal locations of the lesion, and non-continuous rectangular, biphasic current pulses (0.7 V, 5 Hz) were administered 1 hour daily for 2 consecutive weeks...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27904498/pre-degenerated-peripheral-nerves-co-cultured-with-bone-marrow-derived-cells-a-new-technique-for-harvesting-high-purity-schwann-cells
#5
Xiao-Pan Wang, Min Wu, Jian-Zhong Guan, Zhao-Dong Wang, Xu-Bin Gao, Yang-Yang Liu
Schwann cells play an important role in the peripheral nervous system, especially in nerve repair following injury, so artificial nerve regeneration requires an effective technique for obtaining purified Schwann cells. In vivo and in vitro pre-degeneration of peripheral nerves have been shown to obtain high-purity Schwann cells. We believed that in vitro pre-degeneration was simple and controllable, and available for the clinic. Thus, we co-cultured the crushed sciatic nerves with bone marrow-derived cells in vitro...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27893553/healing-effects-of-platelet-rich-plasma-on-peripheral-nerve-injuries
#6
Farshid Bastami, Peyman Vares, Arash Khojasteh
Regeneration of peripheral nerve injuries (PNIs) has been a major challenging issue in regenerative medicine and tissue engineering. Inferior alveolar nerve and lingual nerve injuries are the major difficulties and complications of oral surgeries following dental implant placement, etc. The aim of this study was to systematically review the effects of platelet-rich plasma (PRP) on the regeneration of PNIs. Medline NCBI databases were searched for related articles up to and including May 2016. Being published in English papers, use of PRP in peripheral nerve regeneration, in vivo studies, and having histological evaluations was the inclusion criteria...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27890336/complications-and-revision-amputation-following-trauma-related-lower-limb-loss
#7
Eric Edison Low, Elizabeth Inkellis, Saam Morshed
INTRODUCTION: Trauma-related amputations are a common cause of limb loss in the United States. Despite the military and public health impact of trauma-related amputations, distributions of various lower limb amputations and the relative frequency of complications and revision amputations have not been well described. We used the National Trauma Data Bank (NTDB) in order to investigate the epidemiology of trauma-related lower extremity amputations among civilians in U.S. trauma centers...
November 18, 2016: Injury
https://www.readbyqxmd.com/read/27887768/evaluation-of-acute-kidney-injury-using-contrast-ultrasonography-in-a-rabbit-model-of-crush-syndrome
#8
Chundong Zhang, Xin Wang, Jie Tang
This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression...
November 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27880769/effects-of-treatment-of-treadmill-combined-with-electro-acupuncture-on-tibia-bone-mass-and-substance-pexpression-of-rabbits-with-sciatic-nerve-injury
#9
Yan Wang, Qiang Tang, Luwen Zhu, Ruyi Huang, Lei Huang, Melanie Koleini, Dequan Zou
The peripheral nervous system may play an important role in normal bone maintenance and remodeling. Substance P (SP) is a neuropeptide associated with bone loss and formation that may mediate the effects of the nervous system. The purpose of this study is to determine if treadmill running combined with electro-acupuncture at Jiaji acupoints (Jiaji-EA) affects tibial bone mass and SP expression in rabbits with sciatic nerve injury. Twenty-four juvenile male New Zealand white rabbits were randomly assigned to one of 4 groups: sham injury control (sham), sciatic never crush control (SNCr), treadmill running (treadmill), and Jiaji-EA combined with treadmill running (ET group)...
2016: PloS One
https://www.readbyqxmd.com/read/27878997/corneal-epithelial-cells-function-as-surrogate-schwann-cells-for-their-sensory-nerves
#10
REVIEW
Mary Ann Stepp, Gauri Tadvalkar, Raymond Hakh, Sonali Pal-Ghosh
The eye is innervated by neurons derived from both the central nervous system and peripheral nervous system (PNS). While much is known about retinal neurobiology and phototransduction, less attention has been paid to the innervation of the eye by the PNS and the roles it plays in maintaining a functioning visual system. The ophthalmic branch of the trigeminal ganglion contains somas of neurons that innervate the cornea. These nerves provide sensory functions for the cornea and are referred to as intraepithelial corneal nerves (ICNs) consisting of subbasal nerves and their associated intraepithelial nerve terminals...
November 23, 2016: Glia
https://www.readbyqxmd.com/read/27864032/%C3%AE-1a-adrenergic-receptor-antagonism-improves-erectile-and-cavernosal-responses-in-rats-with-cavernous-nerve-injury-and-enhances-neurogenic-responses-in-human-corpus-cavernosum-from-patients-with%C3%A2-erectile-dysfunction-secondary-to-radical-prostatectomy
#11
Juan I Martínez-Salamanca, José M La Fuente, Eduardo Martínez-Salamanca, Argentina Fernández, Augusto J Pepe-Cardoso, Nuno Louro, Joaquín Carballido, Javier Angulo
INTRODUCTION: Cavernous nerve injury (CNI) in rats and radical prostatectomy (RP) in men result in loss of nitrergic function and increased adrenergic-neurogenic contractions of cavernosal tissue. AIM: To evaluate the modulation of the α-adrenergic system as a strategy to relieve erectile dysfunction (ED) and functional cavernosal alterations induced by CNI. METHODS: A non-selective α-blocker (phentolamine 1 mg/kg daily), a selective α1A-blocker (silodosin [SILOD] 0...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27862629/secreted-ectodomain-of-sialic-acid-binding-ig-like-lectin-9-and-mcp-1-synergistically-regenerate-transected-rat-peripheral-nerves-by-altering-macrophage-polarity
#12
Fumiya Kano, Kohki Matsubara, Minoru Ueda, Hideharu Hibi, Akihito Yamamoto
Peripheral nerves exhibit remarkable self-repairing reparative activity after a simple crush or cut injury. However, the neuronal transection involving a nerve gap overwhelms their repairing activity and causes persistent paralysis. Here, we show that an implantation of the serum-free conditioned medium from stem cells from human exfoliated deciduous teeth (SHED-CM) immersed in a collagen sponge into the nerve gap formed by rat facial nerves transection restored the neurological function. In contrast, SHED-CM specifically depleted of a set of anti-inflammatory M2 macrophage inducers, Monocyte monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (sSiglec-9) lost the ability to restore neurological function in this model...
November 10, 2016: Stem Cells
https://www.readbyqxmd.com/read/27861125/4-aminopyridine-promotes-functional-recovery-and-remyelination-in-acute-peripheral-nerve-injury
#13
Kuang-Ching Tseng, Haiyan Li, Andrew Clark, Leigh Sundem, Michael Zuscik, Mark Noble, John Elfar
Traumatic peripheral nerve damage is a major medical problem without effective treatment options. In repurposing studies on 4-aminopyridine (4-AP), a potassium channel blocker that provides symptomatic relief in some chronic neurological afflictions, we discovered this agent offers significant promise as a small molecule regenerative agent for acute traumatic nerve injury. We found, in a mouse model of sciatic crush injury, that sustained early 4-AP administration increased the speed and extent of behavioral recovery too rapidly to be explained by axonal regeneration...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27858383/effect-of-creatine-on-rat-sciatic-nerve-injury-a-comparative-ultrastructural-study
#14
Fatma Helvacioglu, Ersin Kandemir, Büşra Karabacak, İdil Karataş, Ahmet Peçen, İpek Ercan, Tuğçe Şençelikel, Attila Dağdeviren
AIM: Creatine is an endogenous molecule synthesized in liver, kidney and pancreas from glycin and arginine which is important for mitochondrial metabolism. It is widely used as a supplement for improving muscle mass and function for many years. As it is expected to prevent apoptosis and diminish oxidative stress it is also studied in a number of neurodegenerative diseases for its beneficial effect in recent years. We studied the effect of creatine on the peripheral nerve injury in an experimental rat crush injury model to obtain ultrastructural evidence...
October 13, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27857758/changes-in-microtubule-associated-protein-tau-during-peripheral-nerve-injury-and-regeneration
#15
Guang-Bin Zha, Mi Shen, Xiao-Song Gu, Sheng Yi
Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated, whether tau is involved in peripheral nerve regeneration remains unknown. In the current study, we obtained sciatic nerve tissue from adult rats 0, 1, 4, 7, and 14 days after sciatic nerve crush and examined tau mRNA and protein expression levels and the location of tau in the sciatic nerve following peripheral nerve injury...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27857526/functional-salvage-of-a-hand-after-unsuccessfull-attempt-of-replantation
#16
Ileana Rodica Matei, Alexandru Valentin Georgescu
Amputation by crush injuries generally represents a contraindication for replantation, and especially when the lesion is caused by the summation of multiple concomitant traumatic mechanisms. We present the case of a 22 year- old female who arrived in our service with a crush/torsion amputation of all long fingers at the metacarpo-phalangeal level of the right hand. After the unsuccessful attempt of replantation, the functional reconstruction of the hand was achieved by using a double free flap transfer: anterolateral thigh perforator flap (ALT) and digital block transfer of second and third toes...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27853172/lithium-promotes-dna-stability-and-survival-of-ischemic-retinal-neurocytes-by-upregulating-dna-ligase-iv
#17
Ying Yang, Nandan Wu, Sijia Tian, Fan Li, Huan Hu, Pei Chen, Xiaoxiao Cai, Lijun Xu, Jing Zhang, Zhao Chen, Jian Ge, Keming Yu, Jing Zhuang
Neurons display genomic fragility and show fragmented DNA in pathological degeneration. A failure to repair DNA breaks may result in cell death or apoptosis. Lithium protects retinal neurocytes following nutrient deprivation or partial nerve crush, but the underlying mechanisms are not well defined. Here we demonstrate that pretreatment with lithium protects retinal neurocytes from ischemia-induced damage and enhances light response in rat retina following ischemia-reperfusion injury. Moreover, we found that DNA nonhomologous end-joining (NHEJ) repair is implicated in this process because in ischemic retinal neurocytes, lithium significantly reduces the number of γ-H2AX foci (well-characterized markers of DNA double-strand breaks in situ) and increases the DNA ligase IV expression level...
November 17, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27834589/the-acute-effect-of-cryotherapy-on-muscle-strength-and-shoulder-proprioception
#18
Rui Torres, Filipa Silva, Vera Pedrosa, João Ferreira, Alexandre Lopes
CONTEXT: A common intervention used by clinicians, cryotherapy poses several benefits in managing acute injuries. However, cooling muscle tissue can interfere with muscular properties and the sensory-motor system. OBJECTIVE: The aim of this study was analyse the influence of cryotherapy with a crushed-ice pack on shoulder proprioception concerning joint position sense, force sense, the threshold for detecting passive movement, and maximal force production. DESIGN: A randomised, double-blind controlled trial...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27826464/brachial-artery-reconstruction-in-trauma-using-reversed-arm-vein-from-the-injured-upper-limb
#19
Michael J Ramdass, Patrick Harnarayan
BACKGROUND: Brachial artery repair may be technically challenging with a paucity of guidelines. The use arm vein (AV) from the traumatized limb is herein described. METHODS: Data were prospectively collected from 2002 to 2016 on brachial artery injury including age, sex, mechanism/site of injury, and repair technique. Categories included AV and non-arm vein (NAV) groups. One-year outcomes were noted. RESULTS: All 31 cases studied were of men with an age range of 16 to 73 years (mean = 28)...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27824728/evidence-that-ldl-receptor-related-protein-1-acts-as-an-early-injury-detection-receptor-and-activates-c-jun-in-schwann-cells
#20
Andreas Flütsch, Kenneth Henry, Elisabetta Mantuano, Michael S Lam, Masataka Shibayama, Kazuhisa Takahashi, Steven L Gonias, Wendy M Campana
Schwann cells (SCs) detect injury to peripheral nerves and transform phenotypically to respond to injury and facilitate repair. Cell-signaling pathways and changes in gene expression that drive SC phenotypic transformation in injury have been described; however, the SC receptors that detect peripheral nervous system (PNS) injury have not been identified. LDL receptor-related protein 1 (LRP1) is a receptor for numerous ligands, including intracellular proteins released by injured cells and protein components of degenerated myelin...
December 14, 2016: Neuroreport
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