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Schwartz formula

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https://www.readbyqxmd.com/read/29106301/mirna-processing-gene-polymorphisms-blood-dna-methylation-age-and-long-term-ambient-pm2-5-exposure-in-elderly-men
#1
Jamaji C Nwanaji-Enwerem, Elena Colicino, Lingzhen Dai, Qian Di, Allan C Just, Lifang Hou, Pantel Vokonas, Immaculata De Vivo, Bernardo Lemos, Quan Lu, Marc G Weisskopf, Andrea A Baccarelli, Joel D Schwartz
AIM: We tested whether genetic variation in miRNA processing genes modified the association of PM2.5 with DNA methylation (DNAm) age. PATIENTS & METHODS: We conducted a repeated measures study based on 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n = 940 visits). Address-level 1-year PM2.5 exposures were estimated using the GEOS-chem model. DNAm-age and a panel of 14 SNPs in miRNA processing genes were measured from participant blood samples...
November 6, 2017: Epigenomics
https://www.readbyqxmd.com/read/29098170/interobserver-variability-in-tumor-contouring-affects-the-use-of-radiomics-to-predict-mutational-status
#2
Qiao Huang, Lin Lu, Laurent Dercle, Philip Lichtenstein, Yajun Li, Qian Yin, Min Zong, Lawrence Schwartz, Binsheng Zhao
Radiomic features characterize tumor imaging phenotype. Nonsmall cell lung cancer (NSCLC) tumors are known for their complexity in shape and wide range in density. We explored the effects of variable tumor contouring on the prediction of epidermal growth factor receptor (EGFR) mutation status by radiomics in NSCLC patients treated with a targeted therapy (Gefitinib). Forty-six early stage NSCLC patients (EGFR mutant:wildtype = 20:26) were included. Three experienced radiologists independently delineated the tumors using a semiautomated segmentation software on a noncontrast-enhanced baseline and three-week post-therapy CT scan images that were reconstructed using 1...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29019345/suspect-screening-of-maternal-serum-to-identify-new-environmental-chemical-biomonitoring-targets-using-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#3
Roy R Gerona, Jackie M Schwartz, Janet Pan, Matthew M Friesen, Thomas Lin, Tracey J Woodruff
The use and advantages of high-resolution mass spectrometry (MS) as a discovery tool for environmental chemical monitoring has been demonstrated for environmental samples but not for biological samples. We developed a method using liquid chromatography-quadrupole time-of-flight MS (LC-QTOF/MS) for discovery of previously unmeasured environmental chemicals in human serum. Using non-targeted data acquisition (full scan MS analysis) we were able to screen for environmental organic acids (EOAs) in 20 serum samples from second trimester pregnant women...
October 11, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28990702/prevalence-and-associated-factors-of-impaired-renal-function-in-chinese-children-the-china-health-and-nutrition-survey
#4
Peige Song, Manli Wang, Xinlei Chang, Jiawen Wang, Wei Wei, Lin An
AIM: To assess the prevalence of impaired renal function and its associated factors in Chinese children. METHODS: Children aged 7-18 years in China Health and Nutrition Survey (CHNS) 2009 were included as participants, and their anthropometric measurements, blood pressure (BP) and biochemical parameters were taken for analysis. The estimated glomerular filtration rate (eGFR) was calculated by using the Schwartz "original" formula. RESULTS: The prevalence of estimated glomerular filtration rate (eGFR) < 90 ml/min/1...
October 9, 2017: Nephrology
https://www.readbyqxmd.com/read/28979155/role-of-serum-cystatin-c-and-beta-2-microglobulin-as-early-markers-of-renal-dysfunction-in-children-with-beta-thalassemia-major
#5
Ola Galal Behairy, Eman Rateb Abd Almonaem, Neveen Tawfik Abed, Omima M Abdel Haiea, Rasha M Zakaria, Rania I AbdEllaty, Effat H Asr, Amira Ibrahim Mansour, Amira Mn Abdelrahman, Hoda A Elhady
BACKGROUND: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities. AIM: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions. SUBJECTS AND METHODS: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28905949/electronic-and-molecular-structure-relations-in-diiron-compounds-mimicking-the-fefe-hydrogenase-active-site-studied-by-x-ray-spectroscopy-and-quantum-chemistry
#6
Ramona Kositzki, Stefan Mebs, Nils Schuth, Nils Leidel, Lennart Schwartz, Michael Karnahl, Florian Wittkamp, Daniel Daunke, Andreas Grohmann, Ulf-Peter Apfel, Frédéric Gloaguen, Sascha Ott, Michael Haumann
Synthetic diiron compounds of the general formula Fe2(μ-S2R)(CO)n(L)6-n (R = alkyl or aromatic groups; L = CN(-) or phosphines) are versatile models for the active-site cofactor of hydrogen turnover in [FeFe]-hydrogenases. A series of 18 diiron compounds, containing mostly a dithiolate bridge and terminal ligands of increasing complexity, was characterized by X-ray absorption and emission spectroscopy in combination with density functional theory. Fe K-edge absorption and Kβ main-line emission spectra revealed the varying geometry and the low-spin state of the Fe(i) centers...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28846672/validation-of-serum-creatinine-based-formulae-in-pediatric-renal-transplant-recipients
#7
Omar Alkandari, Diane Hebert, Valerie Langlois, Lisa A Robinson, Rulan S Parekh
BackgroundAccurate monitoring of kidney function is important post-renal transplant; however, the routine use of measured glomerular filtration rate (GFR) or addition of newer serum markers is prohibitively expensive for routine clinical use, especially in children. We validated the modified Schwartz formula in pediatric renal transplant recipients across a range of demographic and clinical characteristics.MethodsIn a retrospective cohort study with nested cross-sectional analysis, we compared 505 measurements of estimated GFR using serum creatinine to simultaneous diethylenetriaminepentaacetic acid (DTPA) nuclear GFR (nGFR) measurements from 173 pediatric kidney transplant recipients who were < 18 years of age from 1 January 2001 to 31 December 2012 accounting for repeated measures...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/28571689/consequences-of-referral-time-and-volume-doubling-time-in-inoperable-patients-with-early-stage-lung-cancer
#8
Michael Frelinghuysen, Jesse Fest, Noelle C Van der Voort Van Zyp, Bronno Van der Holt, Mischa Hoogeman, Joost Nuyttens
BACKGROUND: Inoperable patients with early stage lung cancer are referred late. The purpose was to calculate the referral time and the volume doubling time (VDT), and to investigate its consequence with regard to staging and survival in 117 inoperable patients with early stage lung cancer treated with stereotactic body radiotherapy. MATERIALS AND METHODS: Tumor VDT was calculated using the modified Schwartz formula of exponential growth model and was on the basis of volumes measured on initial diagnostic computed tomography (CT) scans and the planning CT scan...
November 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28546304/comparison-of-methods-of-estimating-creatinine-clearance-in-pediatric-patients
#9
Danielle Padgett, Andrew Ostrenga, Lindsey Lepard
PURPOSE: A retrospective study was conducted to compare various methods of measuring serum creatinine (SCr) values for use in pediatric renal function assessments, including a method aligned with a recently implemented national SCr testing standard. METHODS: Demographic, medication-use, and selected laboratory data were collected from the hospital records of a sample of pediatric patients (n = 91) who underwent 12- or 24-hour timed urine collection for determination of creatinine clearance (CLcr) over a 2-year period...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28540888/assessment-of-renal-function-in-indian-patients-with-sickle-cell-disease
#10
Bhaskar V K S Lakkakula, Henu Kumar Verma, Mona Choubey, Suneeta Patra, Prafukka Kumar Khodiar, Pradeep Kumar Patra
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin. Renal disease is one of the most frequent complications, and kidney damage starts very early and progresses throughout life causing severe complications. The present study is aimed to analyze creatinine-based estimated glomerular filtration rate (eGFR) in 616 SCD patients (507 HbSS and 109 HbSB+), receiving medical care at outpatient wing of Sickle Cell Institute, Chhattisgarh. Glomerular filtration rate (GFR) estimated using the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault, chronic kidney disease epidemiology collaboration (CKD-EPI) (<17 years analyzed with Schwartz), and SCD specific Jamaica Sickle Cell Cohort Study (JSCCS)-GFR equations were compared...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28495651/percentile-categorization-of-qt-interval-as-an-approach-for-identifying-adult-patients-at-risk-for-cardiovascular-death
#11
Reza Mohebi, Ayesha Jehan, Aaron Grober, Victor Froelicher
BACKGROUND: The results from studies of the association of QT prolongation with cardiovascular death (CVD) have been inconsistent. OBJECTIVE: The purpose of this study was to compare the major correction formulas to percentile values of QT for heart rate ranges as to their ability to remove the relationship of QT to heart rate and to predict CVD. METHODS: Participants were 16,531 veterans who had an initial ECG at the Veterans Affairs Medical Center, Palo Alto, between March 31, 1987, and December 20, 1999, and were followed for CVD...
May 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28473317/clinical-and-histopathologic-characteristics-associated-with-renal-outcomes-in-lupus-nephritis
#12
Emilie C Rijnink, Y K Onno Teng, Suzanne Wilhelmus, Mathilde Almekinders, Ron Wolterbeek, Karlien Cransberg, Jan A Bruijn, Ingeborg M Bajema
BACKGROUND AND OBJECTIVES: The prognostic significance of histopathologic (sub)classes in the current classification of lupus nephritis (LN) is controversial. We analyzed clinical and histopathologic predictors of renal outcome in LN outside the framework of the classification. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Variables (50 histopathologic and ten clinical) were tested in mixed, linear, and Cox regression models for their association with renal flare, ESRD, and eGFR during follow-up (1, 5, and 10 years) in 105 patients with LN who underwent biopsy from 1987 to 2011...
May 8, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28236348/fixed-time-interval-compared-with-on-demand-oral-analgesia-protocols-for-post-caesarean-pain-a-randomised-controlled-trial
#13
E Yefet, H Taha, R Salim, J Hasanein, Y Carmeli, N Schwartz, Z Nachum
OBJECTIVES: To compare the efficacy, safety and satisfaction from two modes of oral analgesia administration for the treatment of post-caesarean pain in the first 48 h following surgery: on-demand versus fixed time interval administration. DESIGN: Open label parallel-group, randomised-controlled trial from February to December 2013. SETTING: University-affiliated hospital in Israel. POPULATION: Two-hundred women who underwent caesarean delivery with regional anaesthesia...
June 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28182833/comparative-effectiveness-of-mycophenolate-mofetil-for-the-treatment-of-juvenile-onset-proliferative-lupus-nephritis
#14
Simon Y Tian, Earl D Silverman, Eleanor Pullenayegum, Patrick E Brown, Joseph Beyene, Brian M Feldman
OBJECTIVE: Although juvenile-onset proliferative lupus nephritis (PLN) leads to significant morbidity and mortality, there is no clinical trials-based evidence to support the treatment effectiveness of any therapy for juvenile-onset PLN. Marginal structural models enable us to estimate treatment effectiveness using observational data while accounting for confounding by indication. METHODS: We used prospectively collected data to examine the effect of mycophenolate mofetil (MMF), compared to the use of other therapies, on the long-term outcome of a juvenile-onset PLN cohort (age at PLN onset <18 years)...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28133546/glomerular-and-tubular-renal-function-after-repeated-once-daily-tobramycin-courses-in-cystic-fibrosis-patients
#15
Florian Stehling, Rainer Büscher, Jörg Grosse-Onnebrink, Peter F Hoyer, Uwe Mellies
Introduction. Antibiotic treatment regimens against Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients often include aminoglycoside antibiotics that may cause chronic renal failure after repeated courses. Aminoaciduria is an early marker of acute aminoglycoside-induced renal tubular dysfunction. We hypothesized that urinary amino acid reabsorption is decreased after repeated once-daily tobramycin therapies. Methods. In this prospective cross-sectional study creatinine clearance was estimated by the Schwartz and the Cockcroft-Gault formula...
2017: Pulmonary Medicine
https://www.readbyqxmd.com/read/27995019/colombeau-products-of-distributions
#16
Marija Miteva, Biljana Jolevska-Tuneska, Tatjana Atanasova-Pacemska
In this paper, some products of distributions are derived. The results are obtained in Colombeau algebra of generalized functions, which is the most relevant algebraic construction for dealing with Schwartz distributions. Colombeau algebra [Formula: see text] contains the space [Formula: see text] of Schwartz distributions as a subspace, and has a notion of 'association' that allows us to evaluate the results in terms of distributions.
2016: SpringerPlus
https://www.readbyqxmd.com/read/27982632/direct-approach-to-quantum-tunneling
#17
Anders Andreassen, David Farhi, William Frost, Matthew D Schwartz
The decay rates of quasistable states in quantum field theories are usually calculated using instanton methods. Standard derivations of these methods rely in a crucial way upon deformations and analytic continuations of the physical potential and on the saddle-point approximation. While the resulting procedure can be checked against other semiclassical approaches in some one-dimensional cases, it is challenging to trace the role of the relevant physical scales, and any intuitive handle on the precision of the approximations involved is at best obscure...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27981896/screening-of-renal-dysfunction-among-burkitt-lymphoma-survivors-by-novel-markers
#18
MULTICENTER STUDY
Laila Metwaly Sherief, Doaa Mohammed Youssef, Hanan Saker Sherbiny, Elhamy Abdelkhalek, Mohamed Talaat, Naglaa Ali Khalifa
BACKGROUND: Burkitt lymphoma (BL) represents the most common pathological type of non-Hodgkin lymphoma in our region. Recently, high success rates have been achieved in BL treatment. Little is known about long-term renal dysfunction in this vulnerable group. In the present study, we tried to detect early chronic kidney diseases (CKD) among BL survivors by using novel screening modalities. PATIENTS AND METHODS: we investigated 53 children (aged 10 ± 2.8 years, 34 boys) who successfully treated for Burkitt lymphoma, based on LMB96 protocol, as "patient group" and 30 children as control...
June 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27902155/the-abcs-of-how-we-learn-26-scientifically-proven-approaches-how-they-work-and-when-to-use-them-schwartz-daniel-l-tsang-jessica-m-and-blair-kristen-p-the-abcs-of-how-we-learn-26-scientifically-proven-approaches-how-they-work-and-when-to-use-them-384pp-%C3%A2-17
#19
https://www.readbyqxmd.com/read/27900958/renal-shear-wave-velocity-and-estimated-glomerular-filtration-rate-in-children-with-chronic-kidney-disease
#20
Costanza Bruno, Milena Brugnara, Rocco Micciolo, Mariangela Cecchetto, Michele Zuffante, Alessandra Bucci, Marco Zaffanello
A shear wave velocity (SWV) value obtained by the acoustic radiation force impulse technique depends on tissue elasticity. We investigated the relationship between SWV values and the estimated glomerular filtration rate (eGFR) in children with chronic kidney disease. A total of 29 patients were enrolled in the study. There were 18 primary and 11 secondary cases of vesicoureteral reflux. eGFR was calculated using Schwartz's formulas (2012). Partial eGFR for each kidney was assessed by multiplying the eGFR by the percentage of renal function measured by means of renal (99m)Tc-dimercaptosuccinic acid scintigraphy...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
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