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Schwartz formula

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https://www.readbyqxmd.com/read/29775444/-influence-of-intensity-localization-and-type-of-deposits-in-renal-biopsy-for-disease-symptoms-and-follow-up-in-children-with-iga-nephropathy
#1
Karolina Cichoń-Kawa, Małgorzata Mizerska-Wasiak, Jadwiga Małdyk, Agnieszka Turczyn, Agnieszka Rybi-Szumińska, Anna Wasilewska, Agnieszka Firszt-Adamczyk, Roman Stankiewicz, Beata Bieniaś, Przemysław Sikora, Katarzyna Gadomska-Prokop, Ryszard Grenda, Małgorzata Pańczyk-Tomaszewska
IgA nephropathy is the most common glomerulonephritis in the world. For diagnosis kidney biopsy is necessary. AIM: The aim of the study was assessment the significance of IgA, C3 and IgG deposits intensity and location in kidney childhood IgA nephropathy (IgAN) for the symptoms of the disease and the follow up. MATERIALS AND METHODS: Study population consisted of 81 children, average 11,45±3,99 years. IgAN was recognized based on renal biopsy, performed 1,2±1,84, median 0,5 years after the onset...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775443/-b-type-natriuretic-peptide-as-a-marker-of-cardiac-dysfunction-in-children-with-chronic-kidney-disease
#2
Tomasz Drożdż, Przemko Kwinta, Zbigniew Kordon, Krystyna Sztefko, Andrzej Rudziński, Katarzyna Zachwieja, Monika Miklaszewska, Danuta Czarnecka, Dorota Drożdż
Left ventricular hypertrophy is the most common organ damage in children with chronic kidney disease (CKD). AIM: The aim of the study was to assess the usefulness of B-type natriuretic peptide (BNP) as a marker of heart injury in children with CKD. MATERIALS AND METHODS: We included 66 children (41 boys and 25 girls) aged 0.7 to 18.6 (median 11.6) years with CKD stage 1-5. The concentrations of urea, creatinine, cystatin C and BNP in blood serum were assessed, and the estimated glomerular filtration rate (eGFR) was calculated from the Schwartz and Filler formulas...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29769043/early-renal-damage-among-children-living-in-the-region-of-highest-burden-of-chronic-kidney-disease-of-unknown-etiology-ckdu-in-sri-lanka
#3
S B Agampodi, G S Amarasinghe, P G C R Naotunna, C S Jayasumana, S H Siribaddana
BACKGROUND: Chronic kidney disease of unknown origin (CKDu) in Sri Lanka is grouped with several other epidemics of similar nature across the world as Chronic Interstitial Nephritis in Agricultural Communities (CINAC). In CKDu endemic countries, the focus has mainly been on adults. We hypothesized that studying distribution and factors associated with elevated urine albumin to creatinine ratio (UACR), an early marker of kidney injury, among children living in a CKDu endemic area may provide important clues about the onset and progression of the disease...
May 16, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29743906/glomerular-filtration-decrease-after-diagnostic-cardiac-catheterisation-in-children-with-congenital-cardiac-malformation-the-role-of-serum-creatinine-cystatin-c-neutrophil-gelatinase-and-urine-output-monitoring
#4
Marcin Tkaczyk, Daria Tomczyk, Anna Jander, Sebastian Góreczny, Tomasz Moszura, Paweł Dryżek, Wojciech Krajewski, Ewa Głowacka, Agnieszka Wosiak
Introduction: Diagnosis of contrast induced-nephropathy (CIN) by a classic renal biomarker such as creatinine concentration can be delayed because of various factors that can influence this marker. Changes in new biomarkers such as neutrophil-gelatinase associated lipocalin (NGAL) and cystatin C are postulated to be more sensitive for recognizing patients prone to CIN-acute kidney injury (AKI). Aim: To investigate the role of NGAL and cystatin C as early biomarkers in the diagnosis of kidney injury after cardiac catheterisation...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29735307/combination-of-pediatric-and-adult-formulas-yield-valid-glomerular-filtration-rate-estimates-in-young-adults-with-a-history-of-pediatric-chronic-kidney-disease
#5
Derek K Ng, George J Schwartz, Michael F Schneider, Susan L Furth, Bradley A Warady
As patients with chronic kidney disease (CKD) transition from pediatric nephrology care to adult care, their kidney function is clinically assessed by estimated glomerular filtration rate (eGFR) using both pediatric and adult equations, which may not be congruent. Here we evaluated commonly used eGFR equations and directly measured iohexol GFR (iGFR) among participants between ages 18 and 26 with a diagnosis of pediatric CKD in the Chronic Kidney Disease in Children (CKiD) cohort. The bedside serum creatinine (SCr)-only equation (CKiDSCr ), the SCr-only CKD-EPI (CKD-EPISCr ), the cystatin C (Cys)-only CKD-EPI (CKD-EPICys ) and the combined SCr and Cys CKD-EPI (CKD-EPISCr-Cys ) were compared with a) 279 measured iGFRs obtained from 187 participants and b) 548 eGFRs from the SCr and Cys-based CKiD equation (CKiDSCr-Cys ) obtained from 219 participants...
May 5, 2018: Kidney International
https://www.readbyqxmd.com/read/29534656/tailored-predictive-formulas-for-glomerular-filtration-rate-for-early-detection-of-deteriorating-renal-function-after-pediatric-living-donor-liver-transplant
#6
Toshihiro Yasui, Tatsuya Suzuki, Fujio Hara, Shunsuke Watanabe, Naoko Uga, Atsuki Naoe, Yasuhiro Kondo
OBJECTIVES: In pediatric patients, renal dysfunction after living-donor liver transplant is a major issue that is difficult to evaluate. Recently, predictive equations for Japanese children have been introduced. MATERIALS AND METHODS: We conducted a retrospective study by prospectively collecting data on 26 patients under 16 years old who underwent living-donor liver transplant between June 2004 and March 2015. Serum creatinine and cystatin C levels were measured...
March 9, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29532453/the-association-of-metabolic-dysfunction-with-breastfeeding-outcomes-in-gestational-diabetes
#7
Angelica V Glover, Diane C Berry, Todd A Schwartz, Alison M Stuebe
OBJECTIVE:  To evaluate the relationship between prenatal metabolic markers and breastfeeding outcomes in women with gestational diabetes mellitus (GDM). STUDY DESIGN:  Secondary analysis of a cluster-randomized trial of a lifestyle intervention to improve metabolic health among women with GDM. Women were enrolled between 22 and 36 weeks' gestation and followed through 10 months postpartum. Metabolic markers were measured at enrollment. Women reported when they stopped breastfeeding, whether they breastfed as long as desired, and when they introduced formula...
February 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29531968/development-of-a-modular-fluorescence-overlay-tissue-imaging-system-for-wide-field-intraoperative-surgical-guidance
#8
John Quan Minh Nguyen, Melanie McWade, Giju Thomas, Bryce T Beddard, Jennifer L Herington, Bibhash C Paria, Herbert S Schwartz, Jennifer L Halpern, Ginger E Holt, Anita Mahadevan-Jansen
Fluorescence imaging is a well-established optical modality that has been used to localize and track fluorophores in vivo and has demonstrated great potential for surgical guidance. Despite the variety of fluorophores currently being researched, many existing intraoperative fluorescence imaging systems are specifically designed for a limited number of applications. We present a modular wide-field fluorescence overlay tissue imaging system for intraoperative surgical guidance that is comprised of commercially available standardized components...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29492066/comparison-of-three-formulae-for-estimation-of-glomerular-filtration-rate-in-severely-malnourished-children-at-tertiary-care-facility
#9
Misbah Anjum, Khemchand N Moorani, Bilquis Naeem, Shazia Kulsoom, Ashfaq Ahmed Memon
Objectives: First objective was to compare eGFR by Updated Schwartz (US) and Simple Height Independent (SHID) formula with Original Schwartz (OS) in children with Severe Acute Malnutrition (SAM). The second objective was to compare eGFR in children below and above two years. Methods: This analytic study on estimation of GFR was based on retrospective data collected from 78 children with SAM at Nutritional Rehabilitation Unit from October 2014 - March 2015. Glomerular filtration rate was calculated using serum creatinine (S...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29484708/comparing-different-estimated-glomerular-filtration-rate-equations-in-assessing-glomerular-function-in-children-based-on-creatinine-and-cystatin-c
#10
Seçil Conkar, Sevgi Mir, Fatma Nur Karaslan, Gülden Hakverdi
BACKGROUND: Glomerular filtration rate (GFR) is the best marker used to assess renal function. Estimated GFR (eGFR) equations have been developed, and the ideal formula is still under discussion. We wanted to find the most practical and reliable GFR in eGFR formulas. We compared serum creatinine (Scr)- and cystatin C (cysC)-based eGFR formulas in the literature. We also aimed to determine the suitability and the reliability of cysC for practical use in determining GFR in children. METHODS: We have enrolled 238 children in the study...
February 27, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29421771/serum-beta-trace-protein-for-assessment-of-kidney-function-in-neonates
#11
Nastaran Khosravi, Manoochehr Asgari, Nasrin Khalessi, Rozita Hoseini, Niloofar Khosravi
INTRODUCTION: Compared to the conventional methods, serum beta-trace protein (BTP) has been shown to be more helpful for estimating glomerular filtration rate; however, its value is remained unclear in neonates. The present study aimed to investigate the range of serum BTP level in healthy term neonates and its value to estimate glomerular filtration rate. MATERIALS AND METHODS: This cross-sectional study was conducted on 50 healthy term neonates without underlying cardiovascular or kidney disorders who were admitted to Ali Asghar hospital in 2013...
January 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29311011/-screening-for-nephropathy-in-major-sickle-cell-syndromes-in-patients-monitored-at-the-national-reference-center-for-sickle-cell-disease-in-niamey-niger
#12
Moumouni Garba, Zeinabou Maiga Moussa Tondi, Hassan Diongoule, Samaila Aboubacar, Abdou Ide, Nadège Ruddy Biyao-Nelson, Illiassou Soumaila, Soumana Alido
BACKGROUND: Sickle cell anemia is the most common hereditary hemopathy in the world. It is a disease that attacks all the systems of the organism. The kidneys are among the most sensitive organs of this disease. The main objective of this study is to detect sickle cell nephropathy in patients followed at the National Reference Center for Sickle Cell Disease in Niamey. METHODS: It is a prospective study carried out over a period of one year (January to December 2016)...
January 5, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29229165/measurement-and-estimation-of-glomerular-filtration-rate-in-children
#13
REVIEW
Ayesa N Mian, George J Schwartz
Rapid, accurate, and precise measures of kidney function are essential for daily management of patients. While plasma and urinary clearances provide the greatest accuracy for assessing glomerular filtration rate (GFR), these are often impractical particularly for the care of children. Serum creatinine, the most commonly used endogenous marker, is simple, convenient, and practical but less accurate because of the influence of non-GFR determinants such as muscle mass, which increases with age in children. GFR estimating equations have been developed for adults and children to improve the accuracy of endogenous biomarkers, such as creatinine and cystatin C, by accounting for some of the non-GFR determinants, thus enhancing the practitioner's ability to assess GFR...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29106301/mirna-processing-gene-polymorphisms-blood-dna-methylation-age-and-long-term-ambient-pm-2-5-exposure-in-elderly-men
#14
Jamaji C Nwanaji-Enwerem, Elena Colicino, Lingzhen Dai, Qian Di, Allan C Just, Lifang Hou, Pantel Vokonas, Immaculata De Vivo, Bernardo Lemos, Quan Lu, Marc G Weisskopf, Andrea A Baccarelli, Joel D Schwartz
AIM: We tested whether genetic variation in miRNA processing genes modified the association of PM2.5 with DNA methylation (DNAm) age. PATIENTS & METHODS: We conducted a repeated measures study based on 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n = 940 visits). Address-level 1-year PM2.5 exposures were estimated using the GEOS-chem model. DNAm-age and a panel of 14 SNPs in miRNA processing genes were measured from participant blood samples...
December 2017: Epigenomics
https://www.readbyqxmd.com/read/29098170/interobserver-variability-in-tumor-contouring-affects-the-use-of-radiomics-to-predict-mutational-status
#15
Qiao Huang, Lin Lu, Laurent Dercle, Philip Lichtenstein, Yajun Li, Qian Yin, Min Zong, Lawrence Schwartz, Binsheng Zhao
Radiomic features characterize tumor imaging phenotype. Nonsmall cell lung cancer (NSCLC) tumors are known for their complexity in shape and wide range in density. We explored the effects of variable tumor contouring on the prediction of epidermal growth factor receptor (EGFR) mutation status by radiomics in NSCLC patients treated with a targeted therapy (Gefitinib). Forty-six early stage NSCLC patients (EGFR mutant:wildtype = 20:26) were included. Three experienced radiologists independently delineated the tumors using a semiautomated segmentation software on a noncontrast-enhanced baseline and three-week post-therapy CT scan images that were reconstructed using 1...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29019345/suspect-screening-of-maternal-serum-to-identify-new-environmental-chemical-biomonitoring-targets-using-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#16
Roy R Gerona, Jackie M Schwartz, Janet Pan, Matthew M Friesen, Thomas Lin, Tracey J Woodruff
The use and advantages of high-resolution mass spectrometry (MS) as a discovery tool for environmental chemical monitoring has been demonstrated for environmental samples but not for biological samples. We developed a method using liquid chromatography-quadrupole time-of-flight MS (LC-QTOF/MS) for discovery of previously unmeasured environmental chemicals in human serum. Using non-targeted data acquisition (full scan MS analysis) we were able to screen for environmental organic acids (EOAs) in 20 serum samples from second trimester pregnant women...
March 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28990702/prevalence-and-associated-factors-of-impaired-renal-function-in-chinese-children-the-china-health-and-nutrition-survey
#17
Peige Song, Manli Wang, Xinlei Chang, Jiawen Wang, Wei Wei, Lin An
AIM: To assess the prevalence of impaired renal function and its associated factors in Chinese children. METHODS: Children aged 7-18 years in China Health and Nutrition Survey (CHNS) 2009 were included as participants, and their anthropometric measurements, blood pressure (BP) and biochemical parameters were taken for analysis. The estimated glomerular filtration rate (eGFR) was calculated by using the Schwartz "original" formula. RESULTS: The prevalence of estimated glomerular filtration rate (eGFR) < 90 ml/min/1...
October 9, 2017: Nephrology
https://www.readbyqxmd.com/read/28979155/role-of-serum-cystatin-c-and-beta-2-microglobulin-as-early-markers-of-renal-dysfunction-in-children-with-beta-thalassemia-major
#18
Ola Galal Behairy, Eman Rateb Abd Almonaem, Neveen Tawfik Abed, Omima M Abdel Haiea, Rasha M Zakaria, Rania I AbdEllaty, Effat H Asr, Amira Ibrahim Mansour, Amira Mn Abdelrahman, Hoda A Elhady
BACKGROUND: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities. AIM: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions. SUBJECTS AND METHODS: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28905949/electronic-and-molecular-structure-relations-in-diiron-compounds-mimicking-the-fefe-hydrogenase-active-site-studied-by-x-ray-spectroscopy-and-quantum-chemistry
#19
Ramona Kositzki, Stefan Mebs, Nils Schuth, Nils Leidel, Lennart Schwartz, Michael Karnahl, Florian Wittkamp, Daniel Daunke, Andreas Grohmann, Ulf-Peter Apfel, Frédéric Gloaguen, Sascha Ott, Michael Haumann
Synthetic diiron compounds of the general formula Fe2 (μ-S2 R)(CO)n (L)6-n (R = alkyl or aromatic groups; L = CN- or phosphines) are versatile models for the active-site cofactor of hydrogen turnover in [FeFe]-hydrogenases. A series of 18 diiron compounds, containing mostly a dithiolate bridge and terminal ligands of increasing complexity, was characterized by X-ray absorption and emission spectroscopy in combination with density functional theory. Fe K-edge absorption and Kβ main-line emission spectra revealed the varying geometry and the low-spin state of the Fe(i) centers...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28846672/validation-of-serum-creatinine-based-formulae-in-pediatric-renal-transplant-recipients
#20
Omar Alkandari, Diane Hebert, Valerie Langlois, Lisa A Robinson, Rulan S Parekh
BackgroundAccurate monitoring of kidney function is important post-renal transplant; however, the routine use of measured glomerular filtration rate (GFR) or addition of newer serum markers is prohibitively expensive for routine clinical use, especially in children. We validated the modified Schwartz formula in pediatric renal transplant recipients across a range of demographic and clinical characteristics.MethodsIn a retrospective cohort study with nested cross-sectional analysis, we compared 505 measurements of estimated GFR using serum creatinine to simultaneous diethylenetriaminepentaacetic acid (DTPA) nuclear GFR (nGFR) measurements from 173 pediatric kidney transplant recipients who were < 18 years of age from 1 January 2001 to 31 December 2012 accounting for repeated measures...
December 2017: Pediatric Research
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