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https://www.readbyqxmd.com/read/29244999/mechanical-stress-increases-brain-amyloid-%C3%AE-tau-and-%C3%AE-synuclein-concentrations-in-wild-type-mice
#1
Marcel Levy Nogueira, Minoo Hamraz, Mohammad Abolhassani, Erwan Bigan, Olivier Lafitte, Jean-Marc Steyaert, Bruno Dubois, Laurent Schwartz
INTRODUCTION: Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration. METHODS: Wild-type mice were exposed to multiple regimens of repetitive mild traumatic brain injury, generating a range of combinations of impact energies, frequencies, and durations of exposure. Brain concentrations of amyloid β 1-42 (Aβ1-42), total tau, and α-synuclein were measured by sandwich enzyme-linked immunosorbent assay...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244192/daily-hassles-score-associates-with-the-somatic-and-psychological-health-of-patients-with-crohn-s-disease
#2
Orly Sarid, Vered Slonim-Nevo, Ruslan Sergienko, Avihu Pereg, Elena Chernin, Terri Singer, Dan Greenberg, Doron Schwartz, Hillel Vardi, Michael Friger, Shmuel Odes
OBJECTIVE: To examine the associations of daily hassles with the somatic and psychological health of Crohn's disease (CD) patients. METHOD: A cross-sectional study of 400 self-selected adult CD patients was performed with completion of demographic, medical, and psychosocial questionnaires: economic status; Patient Harvey-Bradshaw Index of disease activity; Daily Hassles Scale (DHS); Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and Short-Form Health Survey (SF-36 Physical and Mental Health) quality of life measures; Brief Symptom Inventory of psychological stress with summary Global Severity Index (GSI); Family Assessment Device; and List of Threatening Life Experiences...
December 15, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29243535/ease-of-learning-judgments-are-based-on-both-processing-fluency-and-beliefs
#3
Andreas Jemstedt, Bennett L Schwartz, Fredrik U Jönsson
Processing fluency influences many types of judgments. Some metacognitive research suggests that the influence of processing fluency may be mediated by participants' beliefs. The current study explores the influence of processing fluency and beliefs on ease-of-learning (EOL) judgments. In two experiments (Exp 1: n = 94; Exp 2: n = 146), participants made EOL judgments on 24 six-letter concrete nouns, presented in either a constant condition (high fluency) with upper-case letters (e.g., BUCKET) or an alternating condition (low fluency) with mixed upper- and lower-case letters (e...
December 15, 2017: Memory
https://www.readbyqxmd.com/read/29243073/clinical-quantification-of-myocardial-blood-flow-using-pet-joint-position-paper-of-the-snmmi-cardiovascular-council-and-the-asnc
#4
Venkatesh L Murthy, Timothy M Bateman, Rob S Beanlands, Daniel S Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D Cerqueira, Robert A deKemp, E Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P Ficaro, Ernest V Garcia, Henry Gewirtz, Gary V Heller, Howard C Lewin, Saurabh Malhotra, April Mann, Terrence D Ruddy, Thomas H Schindler, Ronald G Schwartz, Piotr J Slomka, Prem Soman, Marcelo F Di Carli, Andrew Einstein, Raymond Russell, James R Corbett
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29242396/clinical-quantification-of-myocardial-blood-flow-using-pet-joint-position-paper-of-the-snmmi-cardiovascular-council-and-the-asnc
#5
Venkatesh L Murthy, Timothy M Bateman, Rob S Beanlands, Daniel S Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D Cerqueira, Robert A deKemp, E Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P Ficaro, Ernest V Garcia, Henry Gewirtz, Gary V Heller, Howard C Lewin, Saurabh Malhotra, April Mann, Terrence D Ruddy, Thomas H Schindler, Ronald G Schwartz, Piotr J Slomka, Prem Soman, Marcelo F Di Carli
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29241825/sex-hormones-are-negatively-associated-with-vertebral-bone-marrow-fat
#6
Swaroop D Mistry, Gina N Woods, Sigurdur Sigurdsson, Susan K Ewing, Trisha F Hue, Gudny Eiriksdottir, Kaipin Xu, Joan F Hilton, Deborah M Kado, Vilmundur Gudnason, Tamara B Harris, Clifford J Rosen, Thomas F Lang, Xiaojuan Li, Ann V Schwartz
CONTEXT: Higher bone marrow fat (BMF)1 is associated with osteoporosis and reduced hematopoiesis. Exogenous estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown. OBJECTIVE: To determine if endogenous sex hormones are associated with BMF in older men and women. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Participants using medications that may affect BMF were excluded...
December 11, 2017: Bone
https://www.readbyqxmd.com/read/29241724/measures-of-ses-for-electronic-health-record-based-research
#7
Joan A Casey, Jonathan Pollak, M Maria Glymour, Elizabeth R Mayeda, Annemarie G Hirsch, Brian S Schwartz
INTRODUCTION: Although infrequently recorded in electronic health records (EHRs), measures of SES are essential to describe health inequalities and account for confounding in epidemiologic research. Medical Assistance (i.e., Medicaid) is often used as a surrogate for SES, but correspondence between conventional SES and Medical Assistance has been insufficiently studied. METHODS: Geisinger Clinic EHR data from 2001 to 2014 and a 2014 questionnaire were used to create six SES measures: EHR-derived Medical Assistance and proportion of time under observation on Medical Assistance; educational attainment, income, and marital status; and area-level poverty...
December 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29241588/reanalyzing-neurocognitive-data-on-the-role-of-the-motor-system-in-speech-perception-within-cosmo-a-bayesian-perceptuo-motor-model-of-speech-communication
#8
Marie-Lou Barnaud, Pierre Bessière, Julien Diard, Jean-Luc Schwartz
While neurocognitive data provide clear evidence for the involvement of the motor system in speech perception, its precise role and the way motor information is involved in perceptual decision remain unclear. In this paper, we discuss some recent experimental results in light of COSMO, a Bayesian perceptuo-motor model of speech communication. COSMO enables us to model both speech perception and speech production with probability distributions relating phonological units with sensory and motor variables. Speech perception is conceived as a sensory-motor architecture combining an auditory and a motor decoder thanks to a Bayesian fusion process...
December 11, 2017: Brain and Language
https://www.readbyqxmd.com/read/29241475/israeli-national-policy-for-carbapenem-resistant-enterobacteriaceae-screening-carrier-isolation-and-discontinuation-of-isolation
#9
Ester Solter, Amos Adler, Bina Rubinovitch, Elizabeth Temkin, David Schwartz, Debby Ben-David, Samira Masarwa, Yehuda Carmeli, Mitchell J Schwaber
Since 2006, Israel has been confronting an outbreak of carbapenem-resistant Enterobacteriaceae (CRE), and in 2007 Israel implemented a national strategy to contain spread. The intervention was initially directed toward acute-care hospitals and later expanded to include an established reservoir of carriage in long-term-care hospitals. It included regular reporting of CRE cases to a central registry and daily oversight of management of the outbreak at the institutional level. Microbiological methodologies were standardized in clinical laboratories nationwide...
December 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29241437/the-swiss-mental-health-care-system
#10
Andres R Schneeberger, Bruce J Schwartz
The United States and Switzerland are among the world's wealthiest countries. Both are highly innovative and entrepreneurial, ranking high in global competitiveness and innovation and with similar liberal economies. This column highlights features of the health care system in Switzerland, a country with an exclusively private health insurance system, with federally mandated universal health insurance. Residents can choose from about 58 insurance companies. Switzerland regulates these companies and negotiates reimbursement rates...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241272/oral-cavity-infection-an-underestimated-source-of-pyogenic-spondylodiscitis
#11
Alexander Romagna, Matthias Troeltzsch, Christof Birkenmaier, Christoph Schwartz, Bogdana Suchorska, Stefan Zausinger
No abstract text is available yet for this article.
December 14, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29240564/evaluating-different-criteria-for-defining-a-complete-ambulatory-blood-pressure-monitoring-recording-data-from-the-jackson-heart-study
#12
Samantha G Bromfield, John N Booth, Matthew S Loop, Joseph E Schwartz, Samantha R Seals, Stephen J Thomas, Yuan-I Min, Gbenga Ogedegbe, Daichi Shimbo, Paul Muntner
OBJECTIVE: We determined differences in the prevalence of blood pressure (BP) phenotypes and the association of these phenotypes with left ventricular hypertrophy (LVH) for individuals who fulfilled and did not fulfill various criteria used for defining a complete ambulatory blood pressure monitoring (ABPM) recording. METHODS: We analyzed data for 1141 participants from the Jackson Heart Study. Criteria evaluated included having greater than or equal to 80% of planned readings with more than or equal to one reading per hour (Spanish ABPM Registry criteria), more than or equal to 70% of planned readings with a minimum of 20 daytime and seven nighttime readings (2013 European Society of Hypertension criteria), greater than or equal to 14 daytime and greater than or equal to seven nighttime readings (2003 European Society of Hypertension criteria), more than or equal to 10 daytime and more than or equal to 5 nighttime readings (International Database of Ambulatory Blood Pressure in Relation to Cardiovascular Outcome criteria), and greater than or equal to 14 daytime readings (UK National Institute of Health and Clinical Excellence criteria)...
December 13, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29240455/development-and-evaluation-of-a-student-initiated-test-preparation-program-for-the-usmle-step-1-examination
#13
Lindsay F Schwartz, Matthew Lineberry, Yoon Soo Park, Carol S Kamin, Abbas A Hyderi
PROBLEM: Studies have documented performance on the United States Medical Licensing Examination® (USMLE) Step 1 exam as an important factor that residency program directors consider when deciding which applicants to interview and rank. Therefore, success on this exam, though only one aspect of applicant evaluation, is important in determining future career prospects for medical students. Unfortunately, mean test scores at the University of Illinois College of Medicine at Chicago (UIC) have historically been below the national average...
December 14, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29240006/surgical-consultation-as-social-process-implications-for-shared-decision-making
#14
Justin T Clapp, Alexander F Arriaga, Sushila Murthy, Steven E Raper, J Sanford Schwartz, Frances K Barg, Lee A Fleisher
OBJECTIVE: This qualitative study examines surgical consultation as a social process and assesses its alignment with assumptions of the shared decision-making (SDM) model. SUMMARY OF BACKGROUND DATA: SDM stresses the importance of patient preferences and rigorous discussion of therapeutic risks/benefits based on these preferences. However, empirical studies have highlighted discrepancies between SDM and realities of surgical decision making. Qualitative research can inform understanding of the decision-making process and allow for granular assessment of the nature and causes of these discrepancies...
December 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29239449/synthesis-of-spirocyclic-orthoesters-by-anomalous-rhodium-ii-catalysed-intramolecular-c-h-insertions
#15
Fanny J Lombard, Romain J Lepage, Brett D Schwartz, Ryne C Johnston, Peter C Healy, Elizabeth H Krenske, Mark J Coster
A tetrahydropyranyl acetal bearing a proximal phenyl diazoketone substituent underwent Rh(ii)-catalysed C-H insertion via an 'anomalous' C-O bond-forming, rather than C-C bond-forming, transformation, giving spirocyclic orthoesters. Density functional theory calculations with M06 show that the formation of these anomalous products involves hydride transfer to the rhodium carbene, giving an intermediate zwitterion which undergoes C-O bond formation in preference to C-C bond formation.
December 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29239294/demographics-interests-and-quality-of-life-of-canadian-neurosurgery-residents
#16
Christian Iorio-Morin, Syed Uzair Ahmed, Mark Bigder, Ayoub Dakson, Cameron Elliott, Daipayan Guha, Michelle Kameda-Smith, Pascal Lavergne, Serge Makarenko, Michael S Taccone, Michael K Tso, Bill Wang, Alexander Winkler-Schwartz, David Fortin
BACKGROUND: Neurosurgical residents face a unique combination of challenges, including long duty hours, technically challenging cases, and uncertain employment prospects. We sought to assess the demographics, interests, career goals, self-rated happiness, and overall well-being of Canadian neurosurgery residents. METHODS: A cross-sectional survey was developed and sent through the Canadian Neurosurgery Research Collaborative to every resident enrolled in a Canadian neurosurgery program as of April 1, 2016...
December 14, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29238749/a-feasibility-study-of-neoadjuvant-talazoparib-for-operable-breast-cancer-patients-with-a-germline-brca-mutation-demonstrates-marked-activity
#17
J K Litton, M Scoggins, D L Ramirez, R K Murthy, G J Whitman, K R Hess, B E Adrada, S L Moulder, C H Barcenas, V Valero, J Schwartz Gomez, E A Mittendorf, A Thompson, T Helgason, G B Mills, H Piwnica-Worms, B K Arun
This study was undertaken to determine the feasibility of enrolling breast cancer patients on a single-agent-targeted therapy trial before neoadjuvant chemotherapy. Specifically, we evaluated talazoparib in patients harboring a deleterious BRCA mutation (BRCA+). Patients with a germline BRCA mutation and ≥1 cm, HER2-negative primary tumors were eligible. Study participants underwent a pretreatment biopsy, 2 months of talazoparib, off-study core biopsy, anthracycline, and taxane-based chemotherapy ± carboplatin, followed by surgery...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29237415/family-history-of-prostate-and-colorectal-cancer-and-risk-of-colorectal-cancer-in-the-women-s-health-initiative
#18
Jennifer L Beebe-Dimmer, Cecilia Yee, Electra Paskett, Ann G Schwartz, Dorothy Lane, Nynikka R A Palmer, Cathryn H Bock, Rami Nassir, Michael S Simon
BACKGROUND: Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated. METHODS: Analyses were conducted among participants of the Women's Health Initiative (WHI) observational cohort, free of cancer at the baseline examination. Subjects were followed for colorectal cancer through August 31st, 2009...
December 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29237100/perianal-tuberculosis-in-an-immunocompetent-patient
#19
Gabriela Mosena, Andréia Della Giustina Pires, Jessica Matos D'Almeida Santos, Joel Schwartz, Josué Victorino
Tuberculosis (TB) is a major public health problem worldwide, considered to be the main cause of death from infectious diseases, ranking alongside HIV infection. Skin involvement occurs in 1.5% of the cases, and perianal involvement is extremely rare and tends to occur among immunocompromised patients. Due to its heterogeneous clinical presentation, the diagnosis of cutaneous TB is challenging, requiring a high level of suspicion. This article is protected by copyright. All rights reserved.
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29237024/comparative-analysis-of-neutropenia-in-patients-receiving-prolonged-treatment-with-ceftaroline
#20
R Brigg Turner, D Erin Wilson, Henry Saedi-Kwon, Eric Chang, Regina Won, Dominic Chan, Jacqueline Schwartz
Objectives: Ceftaroline is often used in durations greater than that studied in clinical trials. Several retrospective, non-comparative studies have suggested a higher than anticipated incidence of neutropenia in patients receiving prolonged treatment with ceftaroline. We sought to determine if ceftaroline was associated with neutropenia by comparing the incidence with ceftaroline treatment with treatment with several comparative antibiotics. Methods: Patients receiving 14 or more consecutive days of treatment with ceftaroline were compared with patients receiving cefazolin, daptomycin, linezolid, nafcillin or vancomycin (control group)...
December 8, 2017: Journal of Antimicrobial Chemotherapy
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