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https://www.readbyqxmd.com/read/29471473/bidirectional-gpr119-agonism-requires-peptide-yy-and-glucose-for-activity-in-mouse-and-human-colon-mucosa
#1
Iain R Tough, Sarah Forbes, Herbert Herzog, Robert M Jones, Thue W Schwartz, Helen M Cox
The lipid sensor GPR119 is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, PYY and GLP-1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacylglycerol (2-OG) can each activate GPR119. Here we compared mucosal responses to selective, synthetic GPR119 agonists (AR440006, AR231453) and the lipids, OEA, 2-OG and N-oleoyldopamine (OLDA) monitoring epithelial ion transport as a read-out for L-cell activity in native mouse and human gastrointestinal (GI) mucosae...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471381/efficacy-of-vedolizumab-in-fistulising-crohn-s-disease-exploratory-analyses-of-data-from-gemini-2
#2
Brian G Feagan, David Schwartz, Silvio Danese, David T Rubin, Trevor W Lissoos, Jing Xu, Karen Lasch
Background and Aims: Medical management of fistulising Crohn's disease (CD) is constrained by the limited number of available therapies. We evaluated the efficacy of vedolizumab, a gut-selective α4β7 integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial (NCT00783692). Methods: Exploratory analyses of data from the GEMINI 2 trial were conducted in 461 responders to 6-week vedolizumab induction therapy who received maintenance placebo (VDZ/PBO, N=153) or vedolizumab (VDZ/VDZ, N=308)...
February 17, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29470186/a-comparison-of-outcomes-between-open-hysterectomy-and-robotic-assisted-hysterectomy-for-endometrial-cancer-using-the-national-cancer-database
#3
Joseph Safdieh, Yi-Chun Lee, Andrew Wong, Anna Lee, Joseph P Weiner, David Schwartz, David Schreiber
PURPOSE: The purpose of this study is to evaluate usage patterns and outcomes of women who underwent open hysterectomy (OH) versus robotic assisted-hysterectomy (RAH) for the treatment of endometrial cancer. METHODS: Women with nonmetastatic endometrial adenocarcinoma diagnosed between 2010 and 2012, who either underwent an OH or RAH, were selected from the National Cancer Database. The χ, Fisher exact, or Mann-Whitney U tests were used where appropriate to compare outcomes between groups...
September 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29470092/the-stroop-test-as-a-measure-of-performance-validity-in-adults-clinically-referred-for-neuropsychological-assessment
#4
Laszlo A Erdodi, Sanya Sagar, Kristian Seke, Brandon G Zuccato, Eben S Schwartz, Robert M Roth
This study was designed to develop performance validity indicators embedded within the Delis-Kaplan Executive Function Systems (D-KEFS) version of the Stroop task. Archival data from a mixed clinical sample of 132 patients (50% male; MAge = 43.4; MEducation = 14.1) clinically referred for neuropsychological assessment were analyzed. Criterion measures included the Warrington Recognition Memory Test-Words and 2 composites based on several independent validity indicators. An age-corrected scaled score ≤6 on any of the 4 trials reliably differentiated psychometrically defined credible and noncredible response sets with high specificity (...
February 22, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29470089/towards-hyperpolarization-of-oil-molecules-via-single-nitrogen-vacancy-centers-in-diamond
#5
Pelayo Fernandez-Acebal, Oded Rosolio, Jochen Scheuer, Christoph Müller, Samuel Müller, Simon Schmitt, Liam P McGuinness, Ilai Schwartz, Qiong Chen, Alex Retzker, Boris Naydenov, Fedor Jelezko, Martin B Plenio
Efficient polarization of organic molecules is of extraordinary relevance when performing nuclear magnetic resonance (NMR) and imaging. Commercially available routes to dynamical nuclear polarization (DNP) work at extremely low-temperatures, relying on the solidification of organic samples and thus bringing the molecules out of their ambient thermal conditions. In this work we investigate polarization transfer from optically-pumped nitrogen vacancy centers in diamond to external molecules at room temperature...
February 22, 2018: Nano Letters
https://www.readbyqxmd.com/read/29467479/flat-epithelial-atypia-in-directional-vacuum-assisted-biopsy-of-breast-microcalcifications-surgical-excision-may-not-be-necessary
#6
Zulfia McCroskey, Nour Sneige, Carolyn R Herman, Ross A Miller, Luz A Venta, Jae Y Ro, Mary R Schwartz, Alberto G Ayala
The aim of this study was to analyze the clinicopathological features of patients with flat epithelial atypia, diagnosed in directional vacuum-assisted biopsy targeting microcalcifications, to identify upgrade rate to in situ ductal or invasive breast carcinoma, and determine factors predicting carcinoma in the subsequent excision. We retrospectively evaluated the histological, clinical, and mammographic features of 69 cases from 65 women, with directional vacuum-assisted biopsy-diagnosed flat epithelial atypia with or without atypical ductal hyperplasia or atypical lobular hyperplasia, which underwent subsequent surgical excision...
February 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29466819/feasibility-testing-of-a-wearable-behavioral-aid-for-social-learning-in-children-with-autism
#7
Jena Daniels, Nick Haber, Catalin Voss, Jessey Schwartz, Serena Tamura, Azar Fazel, Aaron Kline, Peter Washington, Jennifer Phillips, Terry Winograd, Carl Feinstein, Dennis P Wall
BACKGROUND:  Recent advances in computer vision and wearable technology have created an opportunity to introduce mobile therapy systems for autism spectrum disorders (ASD) that can respond to the increasing demand for therapeutic interventions; however, feasibility questions must be answered first. OBJECTIVE:  We studied the feasibility of a prototype therapeutic tool for children with ASD using Google Glass, examining whether children with ASD would wear such a device, if providing the emotion classification will improve emotion recognition, and how emotion recognition differs between ASD participants and neurotypical controls (NC)...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29465274/intubation-success-in-critical-care-transport-a-multicenter-study
#8
Ryan J Reichert, Megan Gothard, M David Gothard, Hamilton P Schwartz, Michael T Bigham
INTRODUCTION: Tracheal intubation (TI) is a lifesaving critical care skill. Failed TI attempts, however, can harm patients. Critical care transport (CCT) teams function as the first point of critical care contact for patients being transported to tertiary medical centers for specialized surgical, medical, and trauma care. The Ground and Air Medical qUality in Transport (GAMUT) Quality Improvement Collaborative uses a quality metric database to track CCT quality metric performance, including TI...
February 21, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29463826/vps4-is-a-dynamic-component-of-the-centrosome-that-regulates-centrosome-localization-of-%C3%AE-tubulin-centriolar-satellite-stability-and-ciliogenesis
#9
Carolyn Ott, Dikla Nachmias, Shai Adar, Michal Jarnik, Shachar Sherman, Ramon Y Birnbaum, Jennifer Lippincott-Schwartz, Natalie Elia
The hexameric AAA ATPase VPS4 facilitates ESCRT III filament disassembly on diverse intracellular membranes. ESCRT III components and VPS4 have been localized to the ciliary transition zone and spindle poles and reported to affect centrosome duplication and spindle pole stability. How the canonical ESCRT pathway could mediate these events is unclear. We studied the association of VPS4 with centrosomes and found that GFP-VPS4 was a dynamic component of both mother and daughter centrioles. A mutant, VPS4EQ , which can't hydrolyze ATP, was less dynamic and accumulated at centrosomes...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462444/business-travel-associated-illness-a-geosentinel-analysis
#10
Lin H Chen, Karin Leder, Kira A Barbre, Patricia Schlagenhauf, Michael Libman, Jay Keystone, Marc Mendelson, Philippe Gautret, Eli Schwartz, Marc Shaw, Sue MacDonald, Anne McCarthy, Bradley A Connor, Douglas H Esposito, Davidson Hamer, Mary E Wilson
Background: Analysis of a large cohort of business travelers will help clinicians focus on frequent and serious illnesses. We aimed to describe travel-related health problems in business travelers. Methods: GeoSentinel Surveillance Network consists of 64 travel and tropical medicine clinics in 29 countries; descriptive analysis was performed on ill business travelers, defined as persons traveling for work, evaluated after international travel 1 January 1997 through 31 December 2014...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29462149/the-ino80-chromatin-remodeler-sustains-metabolic-stability-by-promoting-tor-signaling-and-regulating-histone-acetylation
#11
Sean L Beckwith, Erin K Schwartz, Pablo E Garcia-Nieto, Devin A King, Graeme J Gowans, Ka Man Wong, Tessa L Eckley, Alexander P Paraschuk, Egan L Peltan, Laura R Lee, Wei Yao, Ashby J Morrison
Chromatin remodeling complexes are essential for gene expression programs that coordinate cell function with metabolic status. However, how these remodelers are integrated in metabolic stability pathways is not well known. Here, we report an expansive genetic screen with chromatin remodelers and metabolic regulators in Saccharomyces cerevisiae. We found that, unlike the SWR1 remodeler, the INO80 chromatin remodeling complex is composed of multiple distinct functional subunit modules. We identified a strikingly divergent genetic signature for the Ies6 subunit module that links the INO80 complex to metabolic homeostasis...
February 20, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29460670/opioid-prescribing-patterns-among-otolaryngologists
#12
Marissa A Schwartz, James G Naples, Chia-Ling Kuo, Todd E Falcone
Objectives To evaluate national trends in opioid prescribing patterns by otolaryngologists for postoperative pain control after common otolaryngologic procedures. Study Design Cross-sectional; survey. Subjects and Methods A survey to determine opioid prescribing patterns for the treatment of postoperative pain following common otolaryngologic procedures was distributed to all members of the American Academy of Otolaryngology-Head and Neck Surgery. Results The most common pain medication prescribed for adults postoperatively was hydrocodone-acetaminophen (73%), followed by oxycodone-acetaminophen (39%)...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29460130/prevalence-comorbidity-and-correlates-of-psychiatric-and-substance-use-disorders-and-associations-with-hiv-risk-behaviors-in-a-multisite-cohort-of-women-living-with-hiv
#13
Judith A Cook, Jane K Burke-Miller, Pamela J Steigman, Rebecca M Schwartz, Nancy A Hessol, Joel Milam, Daniel J Merenstein, Kathryn Anastos, Elizabeth T Golub, Mardge H Cohen
We used the World Health Organization's Composite International Diagnostic Interview to determine the prevalence, comorbidity, and correlates of lifetime and 12-month behavioral health disorders in a multisite cohort of 1027 women living with HIV in the United States. Most (82.6%) had one or more lifetime disorders including 34.2% with mood disorders, 61.6% with anxiety disorders, and 58.3% with substance use disorders. Over half (53.9%) had at least one 12-month disorder, including 22.1% with mood disorders, 45...
February 19, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29459780/identification-of-distinct-nanoparticles-and-subsets-of-extracellular-vesicles-by-asymmetric-flow-field-flow-fractionation
#14
Haiying Zhang, Daniela Freitas, Han Sang Kim, Kristina Fabijanic, Zhong Li, Haiyan Chen, Milica Tesic Mark, Henrik Molina, Alberto Benito Martin, Linda Bojmar, Justin Fang, Sham Rampersaud, Ayuko Hoshino, Irina Matei, Candia M Kenific, Miho Nakajima, Anders Peter Mutvei, Pasquale Sansone, Weston Buehring, Huajuan Wang, Juan Pablo Jimenez, Leona Cohen-Gould, Navid Paknejad, Matthew Brendel, Katia Manova-Todorova, Ana Magalhães, José Alexandre Ferreira, Hugo Osório, André M Silva, Ashish Massey, Juan R Cubillos-Ruiz, Giuseppe Galletti, Paraskevi Giannakakou, Ana Maria Cuervo, John Blenis, Robert Schwartz, Mary Sue Brady, Héctor Peinado, Jacqueline Bromberg, Hiroshi Matsui, Celso A Reis, David Lyden
The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By employing asymmetric flow field-flow fractionation (AF4), we identified two exosome subpopulations (large exosome vesicles, Exo-L, 90-120 nm; small exosome vesicles, Exo-S, 60-80 nm) and discovered an abundant population of non-membranous nanoparticles termed 'exomeres' (~35 nm). Exomere proteomic profiling revealed an enrichment in metabolic enzymes and hypoxia, microtubule and coagulation proteins as well as specific pathways, such as glycolysis and mTOR signalling...
February 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29458689/the-ysce-yscg-chaperone-and-yscf-n-terminal-sequences-target-yscf-to-the-yersinia-pestis-type-iii-secretion-apparatus
#15
Clarice de Azevedo Souza, Kristian L Richards, YoSon Park, Michael Schwartz, Julie Torruellas Garcia, Sara Schesser Bartra, Gregory V Plano
The needle structures of type III secretion (T3S) systems are formed by the secretion and polymerization of a needle subunit protein, YscF in Yersinia pestis. A subset of T3S systems employ unique heterodimeric chaperones, YscE and YscG in Y. pestis, to prevent the polymerization of needle subunits within the bacterial cell. We demonstrate that the YscE/YscG chaperone is also required for stable YscF expression and for secretion of YscF. Overexpression of a functional maltose-binding protein (MBP)-YscG hybrid protein stabilized cytoplasmic YscF but YscF was not secreted in the absence of YscE...
February 5, 2018: Microbiology
https://www.readbyqxmd.com/read/29458523/hnrnp-g-prevents-inclusion-on-the-hpv16-l1-mrnas-of-the-central-exon-between-splice-sites-sa3358-and-sd3632
#16
Haoran Yu, Lijing Gong, Chengjun Wu, Kersti Nilsson, Xiaoze Li-Wang, Stefan Schwartz
HPV16 late L1 mRNAs encode a short central exon that is located between HPV16 3'-splice site SA3358 and HPV16 5'-splice site SD3632. While SA3358 is used to produce both HPV16 early mRNAs encoding the E6 and E7 oncogenes, and late mRNAs encoding E4, L1 and L2, SD3632 is used exclusively to produce late L1 mRNA. We have previously identified an 8-nucleotide regulatory RNA element that is required for inclusion of the exon between SA3358 and SD3632 to produce L1 mRNAs at the expense of mRNAs polyadenylated at the HPV16 early polyadenylation signal pAE...
February 1, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29458383/cumulative-exposure-to-environmental-pollutants-during-early-pregnancy-and-reduced-fetal-growth-the-project-viva-cohort
#17
Lisa B Rokoff, Sheryl L Rifas-Shiman, Brent A Coull, Andres Cardenas, Antonia M Calafat, Xiaoyun Ye, Alexandros Gryparis, Joel Schwartz, Sharon K Sagiv, Diane R Gold, Emily Oken, Abby F Fleisch
BACKGROUND: Reduced fetal growth is associated with perinatal and later morbidity. Prenatal exposure to environmental pollutants is linked to reduced fetal growth at birth, but the impact of concomitant exposure to multiple pollutants is unclear. The purpose of this study was to examine interactions between early pregnancy exposure to cigarette smoke, traffic pollution, and select perfluoroalkyl substances (PFASs) on birth weight-for-gestational age (BW/GA). METHODS: Among 1597 Project Viva mother-infant pairs, we assessed maternal cigarette smoking by questionnaire, traffic pollution at residential address by black carbon land use regression model, and plasma concentration of select PFASs in early pregnancy...
February 20, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29458265/clean-intermittent-catheterization-rates-after-initial-and-subsequent-treatments-with-onabotulinumtoxina-for-non-neurogenic-overactive-bladder-in-real-world-clinical-settings
#18
Michael Kennelly, Lonny Green, Nancy Alvandi, Salim Wehbe, John Joseph Smith, Scott MacDiarmid, Jeffrey Mangel, Marc Schwartz, Tamer Aboushwareb, Brian Murray
OBJECTIVE: Previous randomized controlled trials have reported a 6.1-6.9% incidence of clean intermittent catheterization (CIC) following treatment with onabotulinumtoxinA in non-neurogenic overactive bladder (OAB) patients who were inadequately managed by ≥1 anticholinergic. A multi-center retrospective chart review assessed the real-world rate of voiding dysfunction requiring catheterization. METHODS: Patients received onabotulinumtoxinA 100U (approved dose) administered by experienced injectors between January 2013 and June 2015...
February 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29456765/peripheral-blood-epi-signature-of-claes-jensen-syndrome-enables-sensitive-and-specific-identification-of-patients-and-healthy-carriers-with-pathogenic-mutations-in-kdm5c
#19
Laila C Schenkel, Erfan Aref-Eshghi, Cindy Skinner, Peter Ainsworth, Hanxin Lin, Guillaume Paré, David I Rodenhiser, Charles Schwartz, Bekim Sadikovic
Background: Claes-Jensen syndrome is an X-linked inherited intellectual disability caused by mutations in the KDM5C gene. Kdm5c is a histone lysine demethylase involved in histone modifications and chromatin remodeling. Males with hemizygous mutations in KDM5C present with intellectual disability and facial dysmorphism, while most heterozygous female carriers are asymptomatic. We hypothesized that loss of Kdm5c function may influence other components of the epigenomic machinery including DNA methylation in affected patients...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29456505/deletion-of-trace-amine-associated-receptor-1-attenuates-behavioral-responses-to-caffeine
#20
Michael D Schwartz, Jeremiah B Palmerston, Diana L Lee, Marius C Hoener, Thomas S Kilduff
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Selective TAAR1 full and partial agonists exhibit similar pro-cognitive, antidepressant- and antipsychotic-like properties in rodents and non-human primates, suggesting TAAR1 as a novel target for the treatment of neurological and psychiatric disorders. We previously reported that TAAR1 partial agonists are wake-promoting in rats and mice, and that TAAR1 knockout (KO) and overexpressing mice exhibit altered sleep-wake and EEG spectral composition...
2018: Frontiers in Pharmacology
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