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S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
September 20, 2016: Quality of Life Research
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
(no author information available yet)
No abstract text is available yet for this article.
July 28, 2016: New England Journal of Medicine
Andrea L Merrill, Ashish K Jha, Justin B Dimick
No abstract text is available yet for this article.
April 7, 2016: New England Journal of Medicine
MaryAnn B Wilbur, Robert S Daum, Howard S Gold
No abstract text is available yet for this article.
March 3, 2016: New England Journal of Medicine
(no author information available yet)
No abstract text is available yet for this article.
February 18, 2016: New England Journal of Medicine
Andrea L Merrill, Laura Esserman, Monica Morrow
No abstract text is available yet for this article.
January 28, 2016: New England Journal of Medicine
Alejandro Rodríguez-González, Ernestina Menasalvas Ruiz, Miguel A Mayer Pujadas
BACKGROUND: In the last few years the use of social media in medicine has grown exponentially, providing a new area of research based on the analysis and use of Web 2.0 capabilities. In addition, the use of social media in medical education is a subject of particular interest which has been addressed in several studies. One example of this application is the medical quizzes of The New England Journal of Medicine (NEJM) that regularly publishes a set of questions through their Facebook timeline...
April 2016: Computer Methods and Programs in Biomedicine
MaryAnn B Wilbur, Sarah Little, Linda M Szymanski
No abstract text is available yet for this article.
December 31, 2015: New England Journal of Medicine
Davide Valentini, Giovanni Ferrara, Reza Advani, Hans O Hallander, Markus J Maeurer
BACKGROUND: Pertussis (whooping cough) remains a public health problem despite extensive vaccination strategies. Better understanding of the host-pathogen interaction and the detailed B. pertussis (Bp) target recognition pattern will help in guided vaccine design. We characterized the specific epitope antigen recognition profiles of serum antibodies ('the reactome') induced by whooping cough and B. pertussis (Bp) vaccines from a case-control study conducted in 1996 in infants enrolled in a Bp vaccine trial in Sweden (Gustafsson, NEJM, 1996, 334, 349-355)...
2015: BMC Immunology
Jeffrey M Drazen, Edward W Campion, Eric J Rubin, Stephen Morrissey, Lindsey R Baden
It has been a year since the first case associated with the current Ebola virus outbreak in West Africa was identified and just over 8 months since we first started reporting on the outbreaks that stemmed from that patient in Guinea. Today's posts at include an anniversary update on the..
February 5, 2015: New England Journal of Medicine
Oswaldo Tolesani Júnior, Christian Nejm Roderjan, Edgard do Carmo Neto, Micheli Mikaeli Ponte, Mariana Cristina Pelli Seabra, Marcos Freitas Knibel
Haff disease associated rhabdomyolysis is correlated with the ingestion of certain freshwater fish and shellfish and is caused by an unidentified toxin. We report the case of a patient who experienced rhabdomyolysis approximately 2 hours after ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga) approximately 3 years after an outbreak had been reported in Manaus, Brazilian Amazon.
October 2013: Revista Brasileira de Terapia Intensiva
Ole-Petter R Hamnvik, Anand Vaidya, Carolyn Becker
This interactive feature presents the case of a 40-year-old woman with pain, weakness, and poor oral intake. She had had a gradual onset of bilateral flank pain spreading to her lower back, abdomen, and extremities. Test your diagnostic and therapeutic skills at
February 13, 2014: New England Journal of Medicine
Peter L Elkin, Andrew Frankel, Ester H Liebow-Liebling, Jared R Elkin, Mark S Tuttle, Steven H Brown
BACKGROUND CANCER SIGNIFICANCE AND QUESTION: BioProspecting is a novel approach that enabled our team to mine genetic marker related data from the New England Journal of Medicine (NEJM) utilizing Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT) and the Human Gene Ontology (HUGO). Genes associated with disorders using the Multi-threaded Clinical Vocabulary Server (MCVS) Natural Language Processing (NLP) engine, whose output was represented as an ontology-network incorporating the semantic encodings of the literature...
May 5, 2012: Metabolomics: Open Access
William F Bond, Linda M Schwartz, Kevin R Weaver, Donald Levick, Michael Giuliano, Mark L Graber
BACKGROUND: Differential diagnosis (DDX) generators are computer programs that generate a DDX based on various clinical data. OBJECTIVE: We identified evaluation criteria through consensus, applied these criteria to describe the features of DDX generators, and tested performance using cases from the New England Journal of Medicine (NEJM©) and the Medical Knowledge Self Assessment Program (MKSAP©). METHODS: We first identified evaluation criteria by consensus...
February 2012: Journal of General Internal Medicine
S Nalliah, S L J Chan, C L S Ong, T H Suthan, K C Tan, V N J She, E Gupta
INTRODUCTION: Internet search has been the main source for information and data mining in medical research. Its use by medical students has immensely contributed to learning activities. The main aim of the study was to determine the effectiveness of internet use by medical students during their initial years of clinical instruction in order to establish a diagnosis after being provided with the history and physical findings of a clinical problem. METHODS: A total of 47 cases derived from the New England Journal of Medicine (NEJM) were utilised...
April 2010: Singapore Medical Journal
Aimé Bonny, Ivo Ditah, Walid Amara, Brahim Hamdaoui, Robert Frank, Jean-Yves Le Heuzey
Until recently it was generally thought that early repolarization is benign. But a recent article in the NEJM (Haissaguerre et al.) suggests that some persons with early repolarization may be at risk of life-threatening ventricular tachyarrhythmia. Unexplained syncope or sudden death occurs mostly during sleep. However, some cases of cardiac arrest during exertion have been reported. We report the case of a 39 year-old black African male with early repolarization pattern on electrocardiogram who regularly experienced dizziness (and one episode of transient loss of consciousness) exclusively while exercising...
2009: Cardiology Journal
Puvan Tharmanathan, Melanie Calvert, John Hampton, Nick Freemantle
BACKGROUND: Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results. METHODS: Systematic search of eight major publications: Annals of Internal Medicine, BMJ, Circulation, CID, JAMA, JCO, Lancet and NEJM, including all randomised controlled trials (RCTs) between June 2000 and May 2005 to identify RCTs that reported use of interim analysis, with or without DMC involvement...
2008: BMC Medical Research Methodology
Marc E Levsky, Alex Rosin, Troy P Coon, William L Enslow, Michael A Miller
INTRODUCTION: The emphasis on publications for promotion in academic medicine would lead one to the theory that authorship numbers would increase proportionally with this emphasis. To investigate authorship trends across a number of periodicals, we performed a descriptive study comparing two full years of published articles spaced ten years apart from five medical journals. METHODS: Physician reviewers each reviewed all articles of one medical journal for the 1995 and 2005 publication years...
April 2007: Southern Medical Journal
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