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https://www.readbyqxmd.com/read/29039110/prognostic-value-of-volumetric-fdg-pet-ct-parameters-in-patients-with-oral-tongue-squamous-cell-carcinoma-who-were-treated-by-superselective-intra-arterial-chemoradiotherapy
#1
Satoko Suzuki-Shibata, Yayoi Yamamoto, Tetsuo Yoshida, Nobutaka Mizoguchi, Tetsuo Nonaka, Akira Kubota, Hiroto Narimatsu, Yohei Miyagi, Toshiaki Kobayashi, Tomohiro Kaneta, Tomio Inoue
PURPOSE: This study aimed to evaluate the predictive and prognostic value of FDG PET/CT-based volumetric parameters in patients with oral tongue squamous cell carcinoma (OTSCC) treated by superselective intra-arterial chemoradiotherapy (IA-CRT). METHODS: We conducted a retrospective study including 33 patients with biopsy-proven OTSCC between May 2007 and February 2016. All of the patients were treated by IA-CRT. Pretreatment SUVmax and metabolic tumor volume (MTV) of the primary tumor were measured...
October 16, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29038339/re-classifying-patients-with-early-stage-hodgkin-lymphoma-based-on-functional-radiographic-markers-at-presentation
#2
Mani Akhtari, Sarah A Milgrom, Chelsea C Pinnix, Jay P Reddy, Wenli Dong, Grace L Smith, Osama Mawlawi, Zeinab Abou Yehia, Jillian Gunther, Eleanor M Osborne, Therese Y Andraos, Christine F Wogan, Eric Rohren, Naveen Garg, Hubert Chuang, Joseph D Khoury, Yasuhiro Oki, Michelle Fanale, Bouthaina S Dabaja
The presence of bulky disease in Hodgkin lymphoma (HL), traditionally defined with a 1-dimensional measurement, can change a patient's risk grouping and thus the treatment approach. We hypothesized that 3-dimensional measurements of disease burden obtained from baseline (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), would more accurately risk stratify patients. To test this hypothesis, we reviewed pretreatment PET-CT scans of patients with stage I-II HL treated at our institution between 2003-2013...
October 16, 2017: Blood
https://www.readbyqxmd.com/read/29036692/clinical-utility-of-texture-analysis-of-18f-fdg-pet-ct-in-patients-with-stage-i-lung-cancer-treated-with-stereotactic-body-radiotherapy
#3
Kazuya Takeda, Kentaro Takanami, Yuko Shirata, Takaya Yamamoto, Noriyoshi Takahashi, Kengo Ito, Kei Takase, Keiichi Jingu
We evaluated the reproducibility and predictive value of texture parameters and existing parameters of 18F-FDG PET/CT images in Stage I non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT). Twenty-six patients with Stage I NSCLC (T1-2N0M0) were retrospectively analyzed. All of the patients underwent an 18F-FDG PET/CT scan before treatment and were treated with SBRT. Each tumor was delineated using PET Edge (MIM Software Inc., Cleveland, OH), and texture parameters were calculated using open-source code CGITA...
September 21, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29030021/hypoxic-volume-evaluated-by-18-f-fluoromisonidazole-positron-emission-tomography-fmiso-pet-may-be-a-prognostic-factor-in-patients-with-oral-squamous-cell-carcinoma-preliminary-analyses
#4
J Sato, Y Kitagawa, S Watanabe, T Asaka, N Ohga, K Hirata, T Shiga, A Satoh, N Tamaki
Tumour hypoxia can be detected by (18)F-fluoromisonidazole positron emission tomography (FMISO-PET). Few studies have assessed the relationships of new PET parameters, including hypoxic volume (HV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG), with 5-year survival of patients treated surgically for oral squamous cell carcinoma (OSCC). This study evaluated the relationships between these PET parameters and 5-year survival in OSCC patients. Twenty-three patients (age 42-84 years; 15 male, eight female) with OSCC underwent FMISO- and (18)F-fluoro-2-deoxyglucose (FDG)-PET computed tomography before surgery...
October 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29026950/the-prognostic-value-of-18-f-fdg-pet-ct-prior-to-liver-transplantation-for-nonresectable-colorectal-liver-metastases
#5
Harald Grut, Svein Dueland, Pål Dag Line, Mona Elisabeth Revheim
PURPOSE: The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28976330/uptake-patterns-of-untreated-primary-gastrointestinal-extranodal-lymphomas-on-initial-staging-18-f-fdg-pet-ct-and-metabolic-tumor-parameters
#6
Engin Alagöz, Kürşat Okuyucu, Semra İnce, Murat Kantarcıoğlu, Şükrü Özaydın, Cumhur Heper, Türker Türker, Nuri Arslan
OBJECTIVE: Non-Hodgkin's lymphomas arising from tissues other than primary lymphatic sites are classified as primary extranodal lymphomas (PEL). PELs of the gastrointestinal system (PGISL) originate from the lymphatic tissues within the gastrointestinal tract. The prognostic value of (18)F-FDG PET/CT in lymphomas is high in terms of both overall survival (OS) and disease-free survival (DFS). Our aim was to investigate the uptake patterns and properties of low-grade and high-grade PGISL on primary staging (18)F-FDG PET/CT, as well as the prognostic significance of metabolic tumor parameters in high grade PGISL...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28950040/fecal-incontinence-in-patients-with-spina-bifida-the-target-is-the-rectum
#7
Charlène Brochard, Alain Ropert, Benoît Peyronnet, Hélène Ménard, Andréa Manunta, Michel Neunlist, Guillaume Bouguen, Laurent Siproudhis
AIMS: The prevalence rate of severe fecal incontinence (FI) in adults with spina bifida (SB) is high. The physiological basis of FI in SB has not been clearly established, which contributes to inadequate care. The aim was to better characterize a large cohort of adults with special consideration of anorectal physiology. METHODS: A multidisciplinary team from a French referral centre for SB prospectively collected data on patients who had an anorectal manometry. Factors associated with severe FI (Cleveland clinical incontinence score ≥ 9) were assessed in a multivariate analysis model...
September 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28940101/the-role-of-interim-fdg-pet-ct-after-induction-chemotherapy-as-a-predictor-of-concurrent-chemoradiotherapy-efficacy-and-prognosis-for-head-and-neck-cancer
#8
Ka-Rham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Sang-Hee Cho, Ik-Joo Chung, Ki Seong Park, Sae-Ryung Kang, Seong Young Kwon, Woong-Ki Chung, Woo Kyun Bae
PURPOSE: Induction chemotherapy (ICT) with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by concurrent chemoradiotherapy (CCRT) has the advantages of organ preservation and systemic control in head and neck cancer (HNC). Early prediction of CCRT efficacy may help identify patients who will benefit more from surgery than from CCRT. We investigated the role of interim 18-fluoro-2-deoxy-glucose positron emission tomography computed tomography (FDG PET-CT) after ICT to predict the efficacy of CCRT and clinical outcomes...
September 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28939071/intraindividual-homogeneity-of-18-f-fdg-pet-ct-parameters-in-hpv-positive-opscc
#9
Shachi Jenny Sharma, Claus Wittekindt, Jennifer Knuth, Dagmar Steiner, Nora Wuerdemann, Maren Laur, Tobias Kroll, Steffen Wagner, Jens Peter Klussmann
OBJECTIVES: (18)F-FDG PET/CT is widely used in clinical oncology. Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in clinical behavior and tumour biology. In these tumours, HPV-oncogenes might lead to distinct alterations in metabolic pathways. Therefore, we compared metabolic parameters using (18)F-FDG PET/CT in HPV-positive and HPV-negative OPSCC in relation to histopathological findings...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28921170/comparison-of-novel-multi-level-otsu-mo-pet-and-conventional-pet-segmentation-methods-for-measuring-fdg-metabolic-tumor-volume-in-patients-with-soft-tissue-sarcoma
#10
Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan, Steve Y Cho
BACKGROUND: We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conventional PET segmentation methods for measuring (18)F-FDG (FDG) PET metabolic tumor volume (MTV) in patients with soft tissue sarcoma (STS). Clinical and imaging data were obtained from the Cancer Imaging Archive. Forty-eight STS patients with FDG PET/CT and MR prior to therapy were analyzed...
September 18, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28918451/quantitative-18-f-dopa-pet-ct-in-pheochromocytoma-the-relationship-between-tumor-secretion-and-its-biochemical-phenotype
#11
Vincent Amodru, Carole Guerin, Sarkis Delcourt, Pauline Romanet, Anderson Loundou, Bruna Viana, Thierry Brue, Frédéric Castinetti, Frédéric Sebag, Karel Pacak, David Taïeb
INTRODUCTION: (18)F-FDOPA illustrates the properties of uptake and storage of catecholamines in pheochromocytomas (PHEOs). Until now, the relationship between (18)F-FDOPA quantitative parameters and a PHEO secretory profile has not been specifically evaluated. MATERIALS AND METHODS: Fifty-six patients (56% females, median age: 47.5 yrs) with non-metastatic PHEO, evaluated by (18)F-FDOPA PET/CT, were included in this retrospective study. Forty-five patients had negative genetic testing (80...
September 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28906411/prognostic-value-of-maximum-standard-uptake-value-metabolic-tumor-volume-and-total-lesion-glycolysis-of-positron-emission-tomography-computed-tomography-in-patients-with-nasopharyngeal-carcinoma-a-systematic-review-and-meta-analysis
#12
REVIEW
Qingfang Li, Jing Zhang, Wei Cheng, Chenjing Zhu, Linyan Chen, Fan Xia, Manni Wang, Fuyao Yang, Xuelei Ma
BACKGROUND: The maximal standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC) perform as new prognostic factors, but the outcomes of the published articles were inconclusive. In this meta-analysis, we evaluated the prognostic value of SUVmax, MTV, and TLG of PET/CT in patients with NPC. METHODS: Relevant English articles were searched in PubMed and EMBASE...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28891217/reproducibility-of-f18-fdg-pet-radiomic-features-for-different-cervical-tumor-segmentation-methods-gray-level-discretization-and-reconstruction-algorithms
#13
Baderaldeen A Altazi, Geoffrey G Zhang, Daniel C Fernandez, Michael E Montejo, Dylan Hunt, Joan Werner, Matthew C Biagioli, Eduardo G Moros
Site-specific investigations of the role of radiomics in cancer diagnosis and therapy are emerging. We evaluated the reproducibility of radiomic features extracted from (18) Flourine-fluorodeoxyglucose ((18) F-FDG) PET images for three parameters: manual versus computer-aided segmentation methods, gray-level discretization, and PET image reconstruction algorithms. Our cohort consisted of pretreatment PET/CT scans from 88 cervical cancer patients. Two board-certified radiation oncologists manually segmented the metabolic tumor volume (MTV1 and MTV2 ) for each patient...
September 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28887761/textural-features-and-suv-based-variables-assessed-by-dual-time-point-18f-fdg-pet-ct-in-locally-advanced-breast-cancer
#14
Ana María Garcia-Vicente, David Molina, Julián Pérez-Beteta, Mariano Amo-Salas, Alicia Martínez-González, Gloria Bueno, María Jesús Tello-Galán, Ángel Soriano-Castrejón
AIM: To study the influence of dual time point 18F-FDG PET/CT in textural features and SUV-based variables and their relation among them. METHODS: Fifty-six patients with locally advanced breast cancer (LABC) were prospectively included. All of them underwent a standard 18F-FDG PET/CT (PET-1) and a delayed acquisition (PET-2). After segmentation, SUV variables (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained...
September 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28878849/prognostic-value-of-tumor-to-blood-standardized-uptake-ratio-in-patients-with-resectable-non-small-cell-lung-cancer
#15
Seunghyeon Shin, Kyoungjune Pak, In Joo Kim, Bum Soo Kim, Seong Jang Kim
OBJECTIVES: Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery. METHODS: Seventy-seven patients who underwent curative resection for NSCLC between January 2010 to December 2013 were enrolled in this study...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28874350/prognostic-significance-of-baseline-metabolic-tumor-volume-in-relapsed-and-refractory-hodgkin-lymphoma
#16
Alison J Moskowitz, Heiko Schöder, Somali Gavane, Katie L Thoren, Martin Fleisher, Joachim Yahalom, Susan J McCall, Briana R Cadzin, Stephanie Y Fox, John Gerecitano, Ravinder Grewal, Paul A Hamlin, Steven M Horwitz, Anita Kumar, Matthew Matasar, Andy Ni, Ariela Noy, M Lia Palomba, Miguel-Angel Perales, Carol S Portlock, Craig Sauter, David Straus, Anas Younes, Andrew D Zelenetz, Craig H Moskowitz
Identification of prognostic factors for patients with relapsed or refractory (rel/ref) Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted approaches. In our phase II study of PET-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifosfamide, carboplatin, etoposide (augICE) we assessed clinical factors, quantitative PET assessments, and cytokines/chemokine values. Transplant-eligible patients with rel/ref HL received 2 (cohort 1) or 3 (cohort 2) cycles of weekly BV; PET-negative (Deauville ≤ 2) patients proceeded to autologous stem cell transplant (ASCT) while PET-positive patients received augICE before ASCT...
September 5, 2017: Blood
https://www.readbyqxmd.com/read/28871162/cervical-nodal-volume-for-prognostication-and-risk-stratification-of-patients-with-nasopharyngeal-carcinoma-and-implications-on-the-tnm-staging-system
#17
Hui Yuan, Qi-Yong Ai, Dora Lai-Wan Kwong, Daniel Yee-Tak Fong, Ann D King, Varut Vardhanabhuti, Victor Ho-Fun Lee, Pek-Lan Khong
We aim to evaluate the quantitative parameters of (18)F-FDG PET/CT (metabolic parameters) and MRI (morphologic parameters) for prognostication and risk stratification in nasopharyngeal carcinoma (NPC). 200 (147 males, aged 50 ± 13 years-old, mean ± S.D.) newly diagnosed patients with NPC (TxNxM0) were prospectively recruited. Primary tumor and nodal lesions were identified and segmented for both morphologic (volume, VOL) and metabolic (SUV and MTV) quantification. Independent predictive factors for recurrence free survival (RFS) and overall survival (OS) were morphologic nodal volume (VOL_N, p < 0...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869177/correlation-of-18-f-fdg-uptake-on-pet-ct-with-ki67-immunohistochemistry-in-pre-treatment-epithelial-ovarian-cancer
#18
M Mayoral, P Paredes, A Saco, P Fusté, P Perlaza, A Tapias, A Fernandez-Martinez, L Vidal, J Ordi, J Pavia, S Martinez-Roman, F Lomeña
OBJECTIVE: Standardized uptake value (SUV) and volumetric parameters such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are useful criteria for disease prognosis in pre-operative and post-treatment epithelial ovarian cancer (EOC). Ki67 is another prognostic biomarker in EOC, associated with tumour aggressiveness. The aim of this study is to evaluate the association between (18)F-FDG PET/CT measurements and Ki67 in pre-treatment EOC to determine if PET/CT parameters could non-invasively predict tumour aggressiveness...
August 28, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28858121/prognostic-value-of-metabolic-variables-of-18f-fdg-pet-ct-in-surgically-resected-stage-i-lung-adenocarcinoma
#19
Xiao-Yi Wang, Yan-Feng Zhao, Ying Liu, Yi-Kun Yang, Ning Wu
The objective of this study was to assess the prognostic value of metabolic tumor burden measured by positron emission tomography/computed tomography (PET/CT) in patients with stage I lung adenocarcinoma.We reviewed 127 consecutive patients with pathologically proven stage I lung adenocarcinoma who underwent pretreatment [18F]FDG PET/CT scans in our hospital from 2005 June to 2012 June. The maximum, mean, and peak standardized uptake value (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and computed tomography volume (CTV) were measured...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28852650/metabolic-tumor-volume-by-18-f-fdg-pet-ct-can-predict-the-clinical-outcome-of-primary-malignant-spine-spinal-tumors
#20
Yoshihiro Matsumoto, Shingo Baba, Makoto Endo, Nokitaka Setsu, Keiichiro Iida, Jun-Ichi Fukushi, Kenichi Kawaguchi, Seiji Okada, Hirofumi Bekki, Takuro Isoda, Yoshiyuki Kitamura, Hiroshi Honda, Yasuharu Nakashima
BACKGROUND AND PURPOSE: Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based (18)F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. MATERIALS AND METHODS: We retrospectively reviewed 27 patients with PMSTs and calculated SUVmax, MTV, and total lesion glycolysis (TLG) to compare their accuracy in predicting progression-free survival (PFS) and overall survival (OS) by receiver operating characteristic (ROC) curve analysis...
2017: BioMed Research International
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