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https://www.readbyqxmd.com/read/28822997/18f-fdg-pet-ct-in-solitary-plasmacytoma-metabolic-behavior-and-progression-to-multiple-myeloma
#1
Domenico Albano, Giovanni Bosio, Giorgio Treglia, Raffaele Giubbini, Francesco Bertagna
PURPOSE: Solitary plasmacytoma (SP) is a rare plasma-cell neoplasm, which can develop both in skeletal and/or soft tissue and frequently progresses to multiple myeloma (MM). Our aim was to study the metabolic behavior of SP and the role of 18F-FDG-PET/CT in predicting progression to MM. MATERIALS AND METHODS: Sixty-two patients with SP who underwent 18F-FDG-PET/CT before any treatment were included. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and compared with age, sex, site of primary disease, and tumor size...
August 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28816978/prognostic-value-of-18f-fdg-pet-ct-parameters-in-patients-with-pancreatic-carcinoma-a-systematic-review-and-meta-analysis
#2
Dongyong Zhu, Lisha Wang, Hanfei Zhang, Jie Chen, Yanfang Wang, Sama Byanju, Meiyan Liao
BACKGROUND: The identification of pancreatic carcinoma (PC) patients with poor prognosis is a priority in clinical oncology because of their high 5-year mortality. However, the prognostic value of pretreatment F-fluorodeoxyglucose (F-FDG)- positron emission tomography (PET)/computed tomography (CT) parameters in PC patients is controversial and no consensus exists as to its predictive capability. This meta-analysis was performed to comprehensively explore the prognostic significance of F-FDG-PET/CT parameters in patients with pancreatic carcinoma...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815452/-18-f-fdg-pet-radiomics-approaches-comparing-and-clustering-features-in-cervical-cancer
#3
Tetsuya Tsujikawa, Tasmiah Rahman, Makoto Yamamoto, Shizuka Yamada, Hideaki Tsuyoshi, Yasushi Kiyono, Hirohiko Kimura, Yoshio Yoshida, Hidehiko Okazawa
OBJECTIVES: The aims of our study were to find the textural features on (18)F-FDG PET/CT which reflect the different histological architectures between cervical cancer subtypes and to make a visual assessment of the association between (18)F-FDG PET textural features in cervical cancer. METHODS: Eighty-three cervical cancer patients [62 squamous cell carcinomas (SCCs) and 21 non-SCCs (NSCCs)] who had undergone pretreatment (18)F-FDG PET/CT were enrolled. A texture analysis was performed on PET/CT images, from which 18 PET radiomics features were extracted including first-order features such as standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), second- and high-order textural features using SUV histogram, normalized gray-level co-occurrence matrix (NGLCM), and neighborhood gray-tone difference matrix, respectively...
August 16, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28814387/effects-of-nk1-receptors-on-gastric-motor-functions-and-satiation-in-healthy-humans-results-from-a-controlled-trial-with-the-nk1-antagonist-aprepitant
#4
Deepti Jacob, Irene A Busciglio, Duane D Burton, Houssam Halawi, Ibironke Oduyebo, Deborah Rhoten, Michael Ryks, W Scott Harmsen, Michael Camilleri
Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. Effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect of aprepitant on gastrointestinal transit. Our aim was to compare, in a randomized, double-blind, placebo-controlled, parallel-group study (12 healthy volunteers per group), effects of aprepitant vs...
August 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28808732/individualized-risk-assessment-in-neuroblastoma-does-the-tumoral-metabolic-activity-on-123-i-mibg-spect-predict-the-outcome
#5
Julian M M Rogasch, Patrick Hundsdoerfer, Christian Furth, Florian Wedel, Frank Hofheinz, Paul-Christian Krüger, Holger Lode, Winfried Brenner, Angelika Eggert, Holger Amthauer, Imke Schatka
PURPOSE: Risk-adapted treatment in children with neuroblastoma (NB) is based on clinical and genetic factors. This study evaluated the metabolic tumour volume (MTV) and its asphericity (ASP) in pretherapeutic (123)I-MIBG SPECT for individualized image-based prediction of outcome. METHODS: This retrospective study included 23 children (11 girls, 12 boys; median age 1.8 years, range 0.3-6.8 years) with newly diagnosed NB consecutively examined with pretherapeutic (123)I-MIBG SPECT...
August 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28790258/-i-prognostic-value-of-metabolic-tumor-volume-mtv-in-patients-with-laryngeal-carcinoma
#6
Kenichiro Yabuki
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28774870/relationship-of-gastric-emptying-or-accommodation-with-satiation-satiety-and-postprandial-symptoms-in-health
#7
Houssam Halawi, Michael Camilleri, Andres Acosta, Maria I Vazquez-Roque, Ibironke Oduyebo, Duane D Burton, Irene A Busciglio, Alan R Zinsmeister
The contributions of gastric emptying (GE) and gastric accommodation (GA) to satiation, satiety, and postprandial symptoms remain unclear. We aimed to evaluate the relationships between GA or GE with satiation, satiety, and postprandial symptoms in healthy overweight or obese volunteers (total n=285, 73% females, mean BMI 33.5kg/m2): 26 prospectively studied obese, otherwise healthy participants and 259 healthy subjects with previous similar GI testing. We assessed GE of solids, gastric volumes, calorie intake at buffet meal, satiation by measuring volume to comfortable fullness (VTF) and maximum tolerated volume (MTV) using Ensure® nutrient drink test (30mL/min), and symptoms 30 minutes after MTV...
August 3, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28767583/percentage-change-of-primary-tumor-on-18f-fdg-pet-ct-as-a-prognostic-factor-for-invasive-ductal-breast-cancer-with-axillary-lymph-node-metastasis-comparison-with-mri
#8
Jang Yoo, Bom Sahn Kim, Jin Chung, Hai-Jeon Yoon
We evaluated the prognostic value of quantitative parameters using dual time point (DTP) F-FDG PET/CT (PET/CT) in invasive ductal breast cancer (IDC) with metastatic axillary lymph nodes (ALN) as compared with dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI.Seventy patients with IDC and metastatic ALN were retrospectively registered. Static PET parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of primary tumor, SUVmax of ALN (SUVALN), and percentage changes (Δ%) in those parameters were measured with DTP PET/CT...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28740918/impact-of-moving-target-on-measurement-accuracy-in-3d-and-4d-pet-imaging-a-phantom-study
#9
Yunfeng Cui, James Bowsher, Jing Cai, Fang-Fang Yin
PURPOSE: The purpose of this study was to evaluate the impact of tumor motion on maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) measurements in both 3-dimensional and respiratory-correlated, 4-dimensional positron emission tomography (PET) imaging. We also evaluated the effect of implementing different attenuation correction methods in 4-dimensional PET image reconstruction on SUVmax and MTV. METHODS AND MATERIALS: An anthropomorphic thorax phantom with a spherical ball as a surrogate for a tumor was used...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28733185/fdg-pet-parameters-as-predictors-of-pathologic-response-and-nodal-clearance-in-patients-with-stage-iii-non-small-cell-lung-cancer-receiving-neoadjuvant-chemoradiation-and-surgery
#10
Andrea L Arnett, Ann T Packard, Kristin Mara, Aaron S Mansfield, Dennis A Wigle, Michael G Haddock, Sean S Park, Kenneth R Olivier, Yolanda I Garces, Kenneth W Merrell
OBJECTIVE: Pathologic complete response (pCR) following neoadjuvant chemoradiation (CRT) is associated with improved outcomes in stage III non-small cell lung cancer. Conflicting results exist regarding the value of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pCR. This study evaluated the association between post-CRT FDG-PET and pCR using novel FDG-PET parameters. METHODS AND MATERIALS: This retrospective study included patients treated with CRT and resection...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28733137/can-metabolic-tumour-parameters-on-primary-staging-18-f-fdg-pet-ct-contribute-to-risk-stratification-of-primary-central-nervous-system-lymphomas-for-patient-management-as-a-prognostic-model
#11
K Okuyucu, E Alagoz, S Ince, S Ozaydin, N Arslan
OBJECTIVE: Primary central nervous system (CNS) lymphoma is an aggressive and fatal extranodal non-Hodgkin lymphoma (NHL) jailed in CNS at initial diagnosis. Its prognosis is poor and the disease has a fatal outcome when compared with systemic NHL. A few baseline risk stratification scoring systems have been suggested to estimate the prognosis mainly based on serum lactate dehydrogenase (LDH) level, age, Karnofsky performance score (KPS), involvement of deep brain structures (DBS) and cerebrospinal fluid protein concentration...
July 18, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28728300/-evaluate-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-mutationsin-epidermal-growth-factor-receptor-in-lung-adenocarcinoma
#12
C Y Ding, W P Yang, Z Guo, J Sun, Y Y Li, T R Li
Objective: To investigate the value of maximum Standardized Uptake Value(SUVmax), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG) calculated from (18)F-FDG PET-CT in predicting the presence of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma. Methods: We retrospectively reviewed 137 lung adenocarcinoma patients with EGFR mutations testing and pretreatment (18)F-FDG PET-CT. Receiver Operating Characteristic (ROC) curve analysis was performed to quantify the predictive value of SUVmax、MTV、TLG...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28716214/early-68-ga-psma-pet-mri-acquisition-assessment-of-lesion-detectability-and-pet-metrics-in-patients-with-prostate-cancer-undergoing-same-day-late-pet-ct
#13
L Domachevsky, H Bernstine, N Goldberg, M Nidam, D Stern, J Sosna, D Groshar
AIM: To compare lesion detectability and positron-emission tomography (PET) metric measurements between early-PET/magnetic resonance imaging (MRI) acquisition and same-day PET/computed tomography (CT). MATERIALS AND METHODS: The study was approved by the institutional review board and written informed consent was obtained from all patients. Twenty-one patients underwent non-time-of-flight (TOF) PET/MRI immediately following (68)GA-prostate-specific membrane antigen (PSMA) tracer injection in two steps: firstly, early prostate PET/MRI (pPET/MRI) and early whole-body (WB) PET/MRI (wbPET/MR) followed by WB TOF PET/CT (wbPET/CT)...
July 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28712692/volumetric-parameters-of-2-deoxy-2-18f-fluoro-d-glucose-positron-emission-tomography-computed-tomography-can-predict-histopathologic-treatment-response-after-neoadjuvant-chemoradiotherapy-in-pancreatic-adenocarcinoma
#14
Makoto Sakane, Mitsuaki Tatsumi, Masatoshi Hori, Hiromitsu Onishi, Takahiro Tsuboyama, Atsushi Nakamoto, Takashi Ota, Hidetoshi Eguchi, Kenichi Wakasa, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: The purpose of this study was to investigate the clinical potential of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography (FDG PET/CT) to evaluate histopathologic effects of preoperative chemoradiotherapy (CRT) in pancreatic adenocarcinoma, with particular focus on volumetric PET/CT parameters. MATERIAL AND METHODS: This study included 25 patients with pancreatic adenocarcinoma who underwent radical surgery after gemcitabine- and S-1-based preoperative-CRT...
June 23, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28711994/-18-f-fdg-pet-ct-features-for-the-molecular-characterization-of-primary-breast-tumors
#15
Lidija Antunovic, Francesca Gallivanone, Martina Sollini, Andrea Sagona, Alessandra Invento, Giulia Manfrinato, Margarita Kirienko, Corrado Tinterri, Arturo Chiti, Isabella Castiglioni
PURPOSE: The aim of this study was to evaluate the role of imaging features derived from [(18)F]FDG-PET/CT to provide in vivo characterization of breast cancer (BC). METHODS: Images from 43 patients with a first diagnosis of BC were reviewed. Images were acquired before any treatment. Histological data were derived from pretreatment biopsy or surgical histological specimen; these included tumor type, grade, ER and PgR receptor status, lymphovascular invasion, Ki67 index, HER2 status, and molecular subtype...
July 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28697193/the-value-of-18-fdg-pet-ct-parameters-hematological-parameters-and-tumor-markers-in-predicting-kras-oncogene-mutation-in-colorectal-cancer
#16
Ali Ozan Oner, Evrim Surer Budak, Senay Yıldırım, Funda Aydın, Cem Sezer
OBJECTIVE: In this study we investigated the predictive value of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), neutrophils/lymphocytes ratio (NLR), platelets/lymphocytes ratio (PLR), carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in the prediction of KRAS gene mutation which plays an important role in the choice of treatment in colorectal cancer patients. SUBJECTS AND METHODS: A total of 55 cases with untreated colorectal cancer who had undergone both PET/CT examinations for initial staging and also mutation analysis of KRAS oncogene were studied...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28695236/volumetric-parameters-on-fdg-pet-can-predict-early-intrahepatic-recurrence-free-survival-in-patients-with-hepatocellular-carcinoma-after-curative-surgical-resection
#17
Jeong Won Lee, Sang Hyun Hwang, Hyun Jeong Kim, Dongwoo Kim, Arthur Cho, Mijin Yun
PURPOSE: This study assessed the prognostic values of volumetric parameters on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting early intrahepatic recurrence-free survival (RFS) after curative resection in patients with hepatocellular carcinoma (HCC). METHODS: A retrospective analysis was performed on 242 patients with HCC who underwent staging FDG PET and subsequent curative surgical resection. The tumor-to-non-tumorous liver uptake ratio, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the HCC lesions on PET were measured...
July 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28690012/prognostic-value-of-metabolic-parameters-of-metastatic-lymph-nodes-on-18-f-fdg-pet-ct-in-patients-with-limited-stage-small-cell-lung-cancer-with-lymph-node-involvement
#18
Feng Jin, Bo Qu, Zheng Fu, Yan Zhang, Anqin Han, Li Kong, Jinming Yu
INTRODUCTION: We assessed the prognostic value of the metabolic parameters of different lesions, including primary tumors and metastatic lymph nodes (LNs), measured by fluorine-18 fluorodeoxyglucose positron emission tomography (PET)/computed tomography in patients with limited-stage small-cell lung cancer (LS-SCLC) with LN metastasis. MATERIALS AND METHODS: The present retrospective study included 46 patients with clinical stage II-III N1-N2 LS-SCLC who had undergone pretreatment fluorine-18 fluorodeoxyglucose PET/computed tomography scanning from January 2011 to December 2014...
June 22, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28689281/optimal-fdg-pet-ct-volumetric-parameters-for-risk-stratification-in-patients-with-locally-advanced-non-small-cell-lung-cancer-results-from-the-acrin-6668-rtog-0235-trial
#19
Ali Salavati, Fenghai Duan, Bradley S Snyder, Bo Wei, Sina Houshmand, Benjapa Khiewvan, Adam Opanowski, Charles B Simone, Barry A Siegel, Mitchell Machtay, Abass Alavi
PURPOSE: In recent years, multiple studies have demonstrated the value of volumetric FDG-PET/CT parameters as independent prognostic factors in patients with non-small cell lung cancer (NSCLC). We aimed to determine the optimal cut-off points of pretreatment volumetric FDG-PET/CT parameters in predicting overall survival (OS) in patients with locally advanced NSCLC and to recommend imaging biomarkers appropriate for routine clinical applications. METHODS: Patients with inoperable stage IIB/III NSCLC enrolled in ACRIN 6668/RTOG 0235 were included...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28685320/can-laws-be-a-potential-pet-image-texture-analysis-approach-for-evaluation-of-tumor-heterogeneity-and-histopathological-characteristics-in-nsclc
#20
Seyhan Karacavus, Bülent Yılmaz, Arzu Tasdemir, Ömer Kayaaltı, Eser Kaya, Semra İçer, Oguzhan Ayyıldız
We investigated the association between the textural features obtained from (18)F-FDG images, metabolic parameters (SUVmax, SUVmean, MTV, TLG), and tumor histopathological characteristics (stage and Ki-67 proliferation index) in non-small cell lung cancer (NSCLC). The FDG-PET images of 67 patients with NSCLC were evaluated. MATLAB technical computing language was employed in the extraction of 137 features by using first order statistics (FOS), gray-level co-occurrence matrix (GLCM), gray-level run length matrix (GLRLM), and Laws' texture filters...
July 6, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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