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Hajira Ilyas, N George Mikhaeel, Joel T Dunn, Fareen Rahman, Henrik Møller, Daniel Smith, Sally F Barrington
PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into 'low' versus 'high' MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consecutive unselected patients with DLBCL, different software algorithms and published methods of MTV measurement using FDG PET. METHOD: Pretreatment MTV was measured on 147 patients treated at Guy's and St Thomas' Hospital...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
S Medina-Ornelas Sevastián, O García-Pérez Francisco, Y Hernández-Pedro Norma, E Arellano-Zarate Angélica, L Abúndiz-López Blanca
OBJECTIVE: To investigate the association between prostatic-specific antigen (PSA) levels and molecular tumor volume (MTV) measured in the68 Ga-PSMA PET/CT, both done in a short period of time, in prostate cancer patients with biochemical failure. METHODS: Eighty-four patients who underwent68 Ga-PSMA PET/CT and measurement of PSA levels in the same week (trigger-PSA) were studied in this retrospective analysis. MTV was calculated from the sum of the metastatic lesions...
February 14, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Su Yeon Ahn, Jin Mo Goo, Kyung Hee Lee, Seunggyun Ha, Jin Chul Paeng
OBJECTIVES: To determine whether the CKD-516 produces a significant change in vascular and metabolic parameters in PET/MRI. MATERIALS AND METHODS: With institutional Animal Care and Use Committee approval, 18 VX2 carcinoma tumors implanted in bilateral back muscles of 9 rabbits were evaluated. Serial PET/MRI were performed before, 4 hours after and 1-week after vascular disrupting agent, CKD-516 at a dose of 0.7 mg/kg (treated group, n = 10) or saline (control group, n = 8) administration...
2018: PloS One
Peiliang Zhang, Zengyun Li, Dongqing Wang, Fuling Ma, Ran Zhang, Wanhua Liang, Mingping Sun, Zheng Fu, Xiaorong Sun
The aim of the present study was to explore the value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in monitoring the early tumor response of esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). A total of 48 patients with pathologically proven ESCC were retrospectively analyzed. All patients underwent two serial 18F-FDG PET scans at baseline (pre-CRT) and 40 Gy/4 weeks of starting radiation therapy (inter-CRT). All patients received intensity-modulated radiotherapy (with a total radiation dose of 59...
February 2018: Oncology Letters
Jun Liang, Ya-Qiang Xie, Qiao Wu, Xiu-Yun Wang, Tao-Tao Liu, Hong-Fang Li, Yuan-Biao Huang, Rong Cao
The design and synthesis of metal-organic frameworks (MOFs) enclosed with multiple catalytic active sites is favorable for cooperative catalysis, but is is still challenging. Herein, we developed a sequential postsynthetic ionization and metalation strategy to prepare bifunctional multivariate Zr-MOFs incorporating zinc porphyrin and imidazolium functionalities. Using this facile strategy, tetratopic [5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]zinc(II) (ZnTCPP) ligands were successfully installed into the cationic Zr-MOF to obtain ZnTCPP⊂(Br-)Etim-UiO-66...
February 12, 2018: Inorganic Chemistry
Mitzy Gafos, Julie Chas, Gilles Pialoux
No abstract text is available yet for this article.
January 29, 2018: International Journal on Drug Policy
Hyung-Jun Im, Tyler Bradshaw, Meiyappan Solaiyappan, Steve Y Cho
Numerous methods to segment tumors using 18F-fluorodeoxyglucose positron emission tomography (FDG PET) have been introduced. Metabolic tumor volume (MTV) refers to the metabolically active volume of the tumor segmented using FDG PET, and has been shown to be useful in predicting patient outcome and in assessing treatment response. Also, tumor segmentation using FDG PET has useful applications in radiotherapy treatment planning. Despite extensive research on MTV showing promising results, MTV is not used in standard clinical practice yet, mainly because there is no consensus on the optimal method to segment tumors in FDG PET images...
February 2018: Nuclear Medicine and Molecular Imaging
Xiao-Yi Wang, Yan-Feng Zhao, Ying Liu, Yi-Kun Yang, Zheng Zhu, Ning Wu
The aim of the study was to investigate the suitable segmentation method in small, low uptake and heterogeneous nodules of stage I lung adenocarcinoma.133 stage I lung adenocarcinoma patients with F-FDG PET/CT scans were enrolled in this retrospective study. All lesions were divided into different groups according to nodule density, nodule size, and the maximum standard uptake value (SUVmax) level. Four different PET segmentation methods were performed, including percentage threshold of SUVmax (T42% and T42% × RC), gradient-based threshold (adaptive iterative algorithm, AT-AIA), and background-related threshold (adaptive thresholding at 40% SUVmax, AT40%) approaches...
December 2017: Medicine (Baltimore)
Ying Liang, Xiaomeng Li, Huan Wan, Yan Fang, Rong Zheng, Wenjie Zhang, Ying Liu, Cong Chen, Ning Wu
OBJECTIVE: The aim of the study was to assess the prognostic impact of volume-based metabolic F-fluorodeoxyglucose-positron emission tomography/ computed tomography (F-FDG-PET/CT) parameters in patients with stage IB-IVA squamous cell cervical carcinoma (SCCC). MATERIALS AND METHODS: We reviewed the pretreatment F-FDG-PET/CT records of 67 patients with stage IB-IVA SCCC. The maximum standardized uptake value (SUVmax) of the primary tumor (PSUVmax), highest SUVmax of the whole malignant lesions (WSUVmax), metabolic tumor volume (MTV) of the primary tumor (PMTV), MTV of the whole malignant lesion (WMTV), total lesion glycolysis (TLG) of primary tumor (PTLG), and TLG of the whole malignant lesion (WTLG) were obtained...
January 24, 2018: Journal of Computer Assisted Tomography
Eden Lowe, John Britton, Jo Cranwell
Aim: To quantify the occurrence of alcohol content, including alcohol branding, in the popular primetime television UK Reality TV show 'Geordie Shore' Series 11. Methods: A 1-min interval coding content analysis of alcohol content in the entire DVD Series 11 of 'Geordie Shore' (10 episodes). Occurrence of alcohol use, implied use, other alcohol reference/paraphernalia or branding was recorded. Results: All categories of alcohol were present in all episodes...
January 21, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
Wenbin Jiang, Hongwei Xue, Qinqin Wang, Xiaojuan Zhang, Zhenguang Wang, Cheng Zhao
OBJECTIVE: The aim of the study was to evaluate clinical value of contrast-enhanced ultrasonography (CEUS) and PET/CT for assessment of extramedullary lymphoma, using histopathology as reference standard. METHOD: A total of 63 patients with histopathologically-confirmed extramedullary lymphoma who had underwent CEUS and PET/CT examinations of suspicious lymph nodes included in the study. CEUS patterns and parameters (arrival time, peak time and intensity, base intensity, area under the time-intensity curve, ascending and descending slopes) and PET/CT parameters including maximum standardized uptake value, mean standardized uptake value, and metabolic tumor volume (MTV) were evaluated...
February 2018: European Journal of Radiology
Won Sub Lim, Jungsu S Oh, Jong-Lyel Roh, Jae Seung Kim, Soo-Jong Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: Adenoid cystic carcinoma (AdCC) in the salivary gland shows a high rate of distant metastasis, which is related to the resulting poor prognosis. We therefore examined the role of pretreatment 18F-FDG PET/CT for prediction of distant metastasis, recurrence/progression, and survival in AdCC. METHODS: This study included 52 patients who underwent pretreatment 18F-FDG PET/CT scanning and subsequent treatments for AdCC. Maximum, mean, and peak standardized uptake value (SUVmax, SUVmean, and SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured on 18F-FDG PET/CT...
February 2018: Oral Oncology
Hyung-Jun Im, Yi Zhang, Huiyun Wu, Jianrong Wu, Najat C Daw, Fariba Navid, Barry L Shulkin, Steve Y Cho
Purpose To preliminarily assess the potential prognostic value of various fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) parameters before, during, and after neoadjuvant chemotherapy (NCT). Materials and Methods Thirty-four patients with osteosarcoma were enrolled prospectively from 2008 to 2012 and underwent FDG PET/computed tomography (CT) imaging before (baseline scan), during (interim scan) and after NCT (posttherapy scan). The study was approved by the institutional review board and informed consent was received from patients...
January 19, 2018: Radiology
Huong Nguyen-Thu, Hirofumi Hanaoka, Takahito Nakajima, Aiko Yamaguchi, Tien Nguyen-Cong, A Adhipatria P Kartamihardja, Yoshito Tsushima
BACKGROUND: We evaluated the potential of diffusion-weighted MRI (DW-MRI) and 18F-FDG-PET for the early prediction of a triple negative breast cancer (TNBC) response to cisplatin. METHODS: Cisplatin-treated TNBC tumor-bearing mice were categorized as responders or non-responders based on the tumor growth rate. DW-MRI and 18F-FDG-PET were performed before and after treatment (day 0 and days 3 and 7, respectively). The average apparent diffusion coefficient value (ADCmean), the highest standardized uptake value (SUVmax), and the metabolic tumor volume (MTV) were measured...
January 22, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Erik Rud, Lien Diep, Eduard Baco
OBJECTIVE: The aim of this study was to evaluate three indirect MRI signs for predicting extraprostatic disease in patients referred to radical prostatectomy: index tumor volume (MTV), apparent diffusion coefficient (ADC) and tumor contact length (TCL). MATERIALS AND METHODS: This prospective study included 183 patients with biopsy proven prostate cancer. In all patients the MTV (ml), ADC (× 10-5 mm2/s) and TCL (mm) of the index tumor were registered at the preoperative MRI...
January 18, 2018: World Journal of Urology
Liang Feng, Shuai Yuan, Liang-Liang Zhang, Kui Tan, Jia-Luo Li, Angelo Kirchon, Ling-Mei Liu, Peng Zhang, Yu Han, Yves J Chabal, Hong-Cai Zhou
Sufficient pore size, appropriate stability and hierarchical porosity are three prerequisites for open frameworks designed for drug delivery, enzyme immobilization and catalysis involving large molecules. Herein, we report a powerful and general strate-gy, linker thermolysis, to construct ultra-stable hierarchically porous metal-organic frameworks (HP-MOFs) with tunable pore size distribution. Linker instability, usually an undesirable trait of MOFs, was exploited to create mesopores by generating crystal defects throughout a microporous MOF crystal via thermolysis...
January 18, 2018: Journal of the American Chemical Society
Adam J Greteman, Sam Stiegler
In this article, Greteman and Stiegler explore the work of becoming queer within the Millennial generation. Collaborative in nature, their investigation turns to three key popular culture texts of the 1990s - Will and Grace, Rent, and MTV's Spring Break - that were central to their then emerging sense of self. Staged as an intragenerational conversation, the authors look to create space to unpack the connections, anecdotal by design, between popular texts and changing ideas of queer identity and community. Since neither author grew up within the confines of a gay ghetto - Boystown of Chicago, the Castro of San Francisco, the East Village of New York City - where they may have encountered and been enamored by the avant-garde queer subcultures so often praised in queer scholarship (for important reasons), they turn instead to experiences with popular culture that opened up lessons in becoming gay, in rural and Midwestern locales where queerness operated and emerged differently...
January 16, 2018: Journal of Homosexuality
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
Chin-Chuan Chang, Shih-Feng Cho, Ya-Wen Chuang, Chia-Yang Lin, Shu-Min Chang, Wen-Ling Hsu, Ying-Fong Huang
Purpose: The purpose of this study was to determine the prognostic significance of metabolic parameters on pre-treatment 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG PET/CT), in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-containing therapy. Materials and Methods: From September 2009 to December 2014, DLBCL patients who had received FDG PET/CT scans for staging were enrolled. The maximal standardized uptake value of tumor (SUVt) was recorded...
November 21, 2017: Oncotarget
Do Hyoung Lim, Jai Hyuen Lee
Purpose: This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods: The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL...
December 2017: Nuclear Medicine and Molecular Imaging
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