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https://www.readbyqxmd.com/read/28212997/differential-expression-and-prognostic-significance-of-glut1-according-to-histologic-type-of-non-small-cell-lung-cancer-and-its-association-with-volume-dependent-parameters
#1
Young Wha Koh, Su Jin Lee, Seong Yong Park
BACKGROUND: We evaluated glucose transporter type 1 (GLUT1) and carbonic anhydrase IX (CAIX) expression, together with volume-based(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) parameters, in non-small cell lung cancer (NSCLC) patients, and examined the prognostic significance of those parameters according to its histologic subtype. METHOD: A total of 269 patients, who underwent surgical resection for NSCLC, were reviewed retrospectively. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were measured by preoperative (18)F-fluorodeoxyglucose positron emission tomography computed tomography...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28195905/value-of-intratumoral-metabolic-heterogeneity-and-quantitative-18f-fdg-pet-ct-parameters-to-predict-prognosis-in-patients-with-hpv-positive-primary-oropharyngeal-squamous-cell-carcinoma
#2
Esther Mena, Mehdi Taghipour, Sara Sheikhbahaei, Abhinav K Jha, Arman Rahmim, Lilja Solnes, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: We retrospectively investigated 105 patients with HPV-positive OPSCC. SUVmax and metabolic tumor volume (MTV) were measured for the primary tumors and when available for the metastatic sites. Primary tumor intratumoral metabolic heterogeneity was calculated as the area under a cumulative SUV volume histograms curve (AUC-CSH)...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28188325/correlation-between-tumour-characteristics-suv-measurements-metabolic-tumour-volume-tlg-and-textural-features-assessed-with-18-f-fdg-pet-in-a-large-cohort-of-oestrogen-receptor-positive-breast-cancer-patients
#3
Charles Lemarignier, Antoine Martineau, Luis Teixeira, Laetitia Vercellino, Marc Espié, Pascal Merlet, David Groheux
PURPOSE: The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC). METHODS: 171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an (18)F-FDG PET examination before NAC...
February 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28179532/a-murine-herpesvirus-closely-related-to-ubiquitous-human-herpesviruses-causes-t-cell-depletion
#4
Swapneel J Patel, Guoyan Zhao, Vinay R Penna, Eugene Park, Elvin J Lauron, Ian B Harvey, Wandy L Beatty, Beatrice Plougastel-Douglas, Jennifer Poursine-Laurent, Daved H Fremont, David Wang, Wayne M Yokoyama
Mouse models of human herpesvirus infections The human roseoloviruses HHV6A, HHV6B, and HHV7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many diseases; however, it has been challenging to establish infections with Roseoloviruses as direct drivers of pathology because they are nearly ubiquitous and display species-specific tropism. Furthermore, controlled study of infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus has not been identified...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28178131/prognostic-value-of-18f-fdg-pet-ct-based-functional-parameters-in-patients-with-soft-tissue-sarcoma-a-meta-analysis
#5
Linyan Chen, Xin Wu, Xuelei Ma, Linghong Guo, Chenjing Zhu, Qingfang Li
BACKGROUND: Considering the clinical importance of high 5-year mortality, we performed a meta-analysis of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) from F-FDG PET-CT for overall survival (OS) and progression-free survival (PFS) in patients with soft tissue sarcoma. METHODS: The search and selection of eligible articles was conducted on PubMed and EMBASE. We applied hazard ratio (HR) and odd ratio (OR) to measure the correlation between SUVmax, MTV, and TLG with PFS and OS...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28161825/correlation-between-kras-mutation-and-18-f-fdg-uptake-in-stage-iv-colorectal-cancer
#6
Arthur Cho, Kwanhyeong Jo, Sang Hyun Hwang, Narae Lee, Minkyu Jung, Mijin Yun, Hee Sung Hwang
PURPOSE: The purpose of this study is to evaluate the correlation between KRAS mutation, (18)F-FDG uptake, and metastatic pattern in advanced stage colorectal cancer (CRC) patients. METHODS: Medical records of stage IV CRC patients who underwent (18)F-FDG PET/CT for staging and KRAS mutation analysis were selected. On PET scans, a volume of interest (VOI) was drawn on the primary lesion. (18)F-FDG indices (SUVmax, SUVmean, MTV, TLG) of the primary lesions were obtained and correlated with KRAS mutation of the primary lesion...
February 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28134692/prognostic-value-of-metabolic-tumor-volume-and-total-lesion-glycolysis-on-preoperative-18f-fdg-pet-ct-in-patients-with-renal-cell-carcinoma
#7
Reiko Nakajima, Yuka Matsuo, Tsunenori Kondo, Koichiro Abe, Shuji Sakai
PURPOSE: We evaluated the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured using pretreatment F-FDG PET/CT in patients with renal cell carcinoma (RCC). METHODS: A total of 139 patients with RCC who had undergone FDG PET/CT before tumor resection were retrospectively reviewed. We determined the SUVmax, MTV, and TLG and compared the results obtained with those required for a progression-free survival (PFS), which was defined as disease progression...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28118260/effect-of-different-segmentation-algorithms-on-metabolic-tumor-volume-measured-on-18f-fdg-pet-ct-of-cervical-primary-squamous-cell-carcinoma
#8
Weina Xu, Shupeng Yu, Ying Ma, Changping Liu, Jun Xin
BACKGROUND AND PURPOSE: It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation algorithms on the PET/CT-based MTV and their correlations with the gross tumor volumes (GTVs) of cervical primary squamous cell carcinoma. MATERIALS AND METHODS: Fifty-five patients with International Federation of Gynecology and Obstetrics stage Ia∼IIb and histologically proven cervical squamous cell carcinoma were enrolled...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28110346/prognostic-value-of-molecular-and-imaging-biomarkers-in-patients-with-supratentorial-glioma
#9
Egesta Lopci, Marco Riva, Laura Olivari, Fabio Raneri, Riccardo Soffietti, Arnoldo Piccardo, Alberto Bizzi, Pierina Navarria, Anna Maria Ascolese, Roberta Rudà, Bethania Fernandes, Federico Pessina, Marco Grimaldi, Matteo Simonelli, Marco Rossi, Tommaso Alfieri, Paolo Andrea Zucali, Marta Scorsetti, Lorenzo Bello, Arturo Chiti
PURPOSE: We evaluated the relationship between (11)C-methionine PET ((11)C-METH PET) findings and molecular biomarkers in patients with supratentorial glioma who underwent surgery. METHODS: A consecutive series of 109 patients with pathologically proven glioma (64 men, 45 women; median age 43 years) referred to our Institution from March 2012 to January 2015 for tumour resection and who underwent preoperative (11)C-METH PET were analysed. Semiquantitative evaluation of the (11)C-METH PET images included SUVmax, region of interest-to-normal brain SUV ratio (SUVratio) and metabolic tumour volume (MTV)...
January 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28072621/risk-stratification-of-pediatric-patients-with-neuroblastoma-using-volumetric-parameters-of-18f-fdg-and-18f-dopa-pet-ct
#10
Chia-Ju Liu, Meng-Yao Lu, Yen-Lin Liu, Chi-Lun Ko, Kuan-Yin Ko, Kai-Yuan Tzen, Hsiu-Hao Chang, Yung-Li Yang, Shiann-Tarng Jou, Wen-Ming Hsu, Ruoh-Fang Yen
PURPOSE: This study determined the prognostic value of volumetric parameters derived from pretreatment F-FDG and F-DOPA PET/CT of neuroblastoma and their correlation with clinical and histopathologic features. PATIENTS AND METHODS: A total of 25 children with neuroblastoma underwent pretreatment F-FDG and F-DOPA PET/CT within 4 weeks. The SUVmax of primary tumors on F-FDG and F-DOPA PET were recorded as SUVFDG and SUVDOPA, respectively. For volumetric parameters of primary tumors, 40% of SUVmax was used to generate volume of interest...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28068244/-18-f-fluorodeoxyglucose-positron-emission-tomography-predicts-patterns-of-failure-after-definitive-chemoradiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#11
Nitin Ohri, William R Bodner, Balazs Halmos, Haiying Cheng, Roman Perez-Soler, Steven M Keller, Shalom Kalnicki, Madhur Garg
BACKGROUND: We previously reported that pretreatment positron emission tomography (PET) identifies lesions at high risk for progression after concurrent chemoradiation therapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). Here we validate those findings and generate tumor control probability (TCP) models. METHODS: We identified patients treated with definitive, concurrent CRT for locally advanced NSCLC who underwent staging (18)F-fluorodeoxyglucose/PET/computed tomography...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28048805/su-f-r-42-association-of-radiomic-and-metabolic-tumor-volumes-in-radiation-treatment-of-glioblastoma-multiforme
#12
C Lopez, N Nagornaya, N Parra, D Kwon, F Ishkanian, A Markoe, A Maudsley, R Stoyanova
PURPOSE: High-throughput extraction of imaging and metabolomic quantitative features from MRI and MR Spectroscopy Imaging (MRSI) of Glioblastoma Multiforme (GBM) results in tens of variables per patient. In radiotherapy (RT) of GBM, the relevant metabolic tumor volumes (MTVs) are related to aberrant levels of N-acetyl Aspartate (NAA) and Choline (Cho). Corresponding Clinical Target Volumes (CTVs) for RT planning are based on Contrast Enhancing T1-weighted MRI (CE-T1w) and T2-weighted/Fluid Attenuated Inversion Recovery (FLAIR) MRI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048737/mo-de-207b-01-jack-fowler-junior-investigator-competition-winner-between-somatic-mutations-and-pet-based-radiomic-features-in-non-small-cell-lung-cancer
#13
S Yip, J Kim, T Coroller, E Rios Velazquez, C Parmar, R Mak, H Aerts
PURPOSE: Although PET-based radiomic features have been proposed to quantify tumor heterogeneity and shown promise in outcome prediction, little is known about their relationship with tumor genetics. This study assessed the association of [(18) F]fluorodeoxyglucose (FDG)-PET-based radiomic features with non-small cell lung cancer (NSCLC) mutations. METHODS: 348 NSCLC patients underwent FDG-PET/CT scans before treatment and were tested for genetic mutations. 13% (44/348) and 28% (96/348) patients were found to harbor EGFR (EGFR+) and KRAS (KRAS+) mutations, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047401/tu-ab-202-07-a-novel-method-for-registration-of-mid-treatment-pet-ct-images-under-conditions-of-tumor-regression-for-patients-with-locally-advanced-lung-cancers
#14
Hoda Sharifi, Hong Zhang, Jian-Yyue Jin, Feng-Ming Kong, Indrin J Chetty, Hualiang Zhong
PURPOSE: In PET-guided adaptive radiotherapy (RT), changes in the metabolic activity at individual voxels cannot be derived until the duringtreatment CT images are appropriately registered to pre-treatment CT images. However, deformable image registration (DIR) usually does not preserve tumor volume. This may induce errors when comparing to the target. The aim of this study was to develop a DIR-integrated mechanical modeling technique to track radiation-induced metabolic changes on PET images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035580/simultaneous-pet-mri-assessment-of-response-to-cytotoxic-and-hormone-neo-adjuvant-chemotherapy-in-breast-cancer-a-preliminary-report
#15
Valeria Romeo, Massimiliano D'Aiuto, Giuseppe Frasci, Massimo Imbriaco, Emanuele Nicolai
The aim of this study was to assess the response to cytotoxic and hormone neo-adjuvant chemotherapy in four patients with locally advanced breast cancer by simultaneous PET/MRI. Four patients with locally advanced breast cancer underwent simultaneous PET/MRI of the breast using a 3 T Biograph mMR before and after neo-adjuvant chemotherapy (two patients were treated with hormone-therapy and two patients were treated with cytotoxic chemotherapy). Morpho-structural tumoral features and tumor size were assessed; area value, metabolic (SUV and MTV) and functional (ADC, K trans, V e, k ep and iAUC) data were obtained by positioning regions of interest...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28027744/prognostic-value-of-pretreatment-volume-based-quantitative-18-f-fdg-pet-ct-parameters-in-patients-with-malignant-pleural-mesothelioma
#16
Kazuhiro Kitajima, Hiroshi Doi, Kozo Kuribayashi, Masaki Hashimoto, Tatsuya Tsuchitani, Masao Tanooka, Kazuhito Fukushima, Takashi Nakano, Seiki Hasegawa, Shozo Hirota
PURPOSE: To investigate the relationships between pretreatment volume-based quantitative (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters and overall survival (OS) in patients with malignant pleural mesothelioma (MPM). MATERIALS AND METHODS: We retrospectively reviewed data from 201 MPM patients, of whom 38 underwent surgical resection, and calculated the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), including primary tumors and nodal or distant metastatic lesions, on pretreatment (18)F-FDG PET/CT...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28011044/association-of-radiomics-and-metabolic-tumor-volumes-in-radiation-treatment-of-glioblastoma-multiforme
#17
Christopher J Lopez, Natalya Nagornaya, Nestor A Parra, Deukwoo Kwon, Fazilat Ishkanian, Arnold M Markoe, Andrew Maudsley, Radka Stoyanova
PURPOSE: To build a framework for investigation of the associations between imaging, clinical target volumes (CTVs), and metabolic tumor volumes (MTVs) features for better understanding of the underlying information in the CTVs and dependencies between these volumes. High-throughput extraction of imaging and metabolomic quantitative features from magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging of glioblastoma multiforme (GBM) results in tens of variables per patient...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28008776/lymph-node-standardized-uptake-values-at-pretreatment-18-f-fluorodeoxyglucose-positron-emission-tomography-as-a-valuable-prognostic-factor-for-distant-metastasis-in-nasopharyngeal-carcinoma
#18
Yuri Jeong, Seunghee Baek, Jae Won Park, Ji Hyeon Joo, Jae Seung Kim, Sang-Wook Lee
OBJECTIVE: The aim of the present study was to evaluate prognostic values of pretreatment (18)F-FDG PET parameters for predicting distant metastasis (DM) of nasopharyngeal cancer. METHODS: Seventy-three patients diagnosed with nasopharyngeal cancer with regional lymph node (LN) involvement who underwent pretreatment (18)F-FDG PET evaluation between January 2005 and December 2012 were retrospectively reviewed. We assessed the (18)F-FDG PET parameters of the primary tumors (T-) and regional LNs (N-)...
December 23, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/28004135/nodal-parameters-of-fdg-pet-ct-performed-during-radiotherapy-for-locally-advanced-mucosal-primary-head-and-neck-squamous-cell-carcinoma-can-predict-treatment-outcomes-suvmean-and-response-rate-are-useful-imaging-biomarkers
#19
Peter Lin, Myo Min, Mark Lee, Lois Holloway, Dion Forstner, Victoria Bray, Allan Fowler
PURPOSE: To evaluate the prognostic utility of nodal metabolic parameters derived from FDG PET/CT performed before radiotherapy (prePET) and during the third week of radiotherapy (iPET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC). METHODS: This analysis included 75 patients with newly diagnosed locally advanced node-positive MPHNSCC treated with radical radiotherapy and concurrent systemic therapy who underwent prePET and iPET: N1 11 patients, N2a 38, N2b 12, N2c 9, N3 5...
December 21, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27984537/18f-fcho-pet-and-mri-for-the-prediction-of-response-in-glioblastoma-patients-according-to-the-rano-criteria
#20
Julie Bolcaen, Marjan Acou, Tom Boterberg, Christian Vanhove, Filip De Vos, Caroline Van den Broecke, Roel Van Holen, Karel Deblaere, Ingeborg Goethals
PURPOSE: In this study, we investigated fluorine-18 fluoromethylcholine (F-FCho) PET and contrast-enhanced MRI for predicting therapy response in glioblastoma (GB) patients according to the Response Assessment in Neuro-Oncology criteria. Our second aim was to investigate which imaging modality enabled prediction of treatment response first. MATERIALS AND METHODS: Eleven GB patients who underwent no surgery or debulking only and received concomitant radiation therapy (RT) and temozolomide were included...
March 2017: Nuclear Medicine Communications
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