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John M Floberg, Kathryn J Fowler, Dominique Fuser, Todd A DeWees, Farrokh Dehdashti, Barry A Siegel, Richard L Wahl, Julie K Schwarz, Perry W Grigsby
BACKGROUND: This study investigated the spatial relationship of 2-deoxy-2-[18 F]-fluoro-D-glucose positron emission tomography ([18 F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derived from magnetic resonance (MR) diffusion imaging on a voxel level using simultaneously acquired PET/MR data. We performed an institutional retrospective analysis of patients with newly diagnosed cervical cancer who received a pre-treatment simultaneously acquired [18 F]FDG-PET/MR...
June 15, 2018: EJNMMI Research
Chelsea C Pinnix, Andrea K Ng, Bouthaina S Dabaja, Sarah A Milgrom, Jillian R Gunther, C David Fuller, Grace L Smith, Zeinab Abou Yehia, Wei Qiao, Christine F Wogan, Mani Akhtari, Osama Mawlawi, L Jeffrey Medeiros, Hubert H Chuang, William Martin-Doyle, Philippe Armand, Ann S LaCasce, Yasuhiro Oki, Michelle Fanale, Jason Westin, Sattva Neelapu, Loretta Nastoupil
Dose-adjusted rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-R-EPOCH) has produced good outcomes in primary mediastinal B-cell lymphoma (PMBCL), but predictors of resistance to this treatment are unclear. We investigated whether [18 F]fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) findings could identify patients with PMBCL who would not respond completely to DA-R-EPOCH. We performed a retrospective analysis of 65 patients with newly diagnosed stage I to IV PMBCL treated at 2 tertiary cancer centers who had PET-CT scans available before and after frontline therapy with DA-R-EPOCH...
June 12, 2018: Blood Advances
Julian C Hong, Yunfeng Cui, Bhavik N Patel, Christel N Rushing, Austin M Faught, Jared S Eng, Kyle Higgins, Fang-Fang Yin, Shiva Das, Brian G Czito, Christopher G Willett, Manisha Palta
PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study investigates the relationship between interim PET imaging during CRT for anal canal cancer and clinical outcome. METHODS AND MATERIALS: From June 2012 to August 2015, 30 patients with anal canal cancer were enrolled in a prospective clinical study of PET prior to and during CRT after ∼30 Gy...
May 4, 2018: International Journal of Radiation Oncology, Biology, Physics
Jasmin Mettler, Horst Müller, Conrad-Amadeus Voltin, Christian Baues, Bernd Klaeser, Alden Moccia, Peter Borchmann, Andreas Engert, Georg Kuhnert, Alexander E Drzezga, Markus Dietlein, Carsten Kobe
Rationale: (18 F)fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography (PET)/computed tomography (CT) for staging Hodgkin lymphoma may allow for accurate and reliable assessment of the metabolic tumour volume (MTV) as baseline risk factor. Our aim was to analyse the prognostic impact of MTV measurements, obtained by different means in advanced-stage Hodgkin lymphoma patients treated within the German Hodgkin Study Group HD18 trial. Methods: Within the German Hodgkin Study Group trial HD18, 310 patients underwent 18 F-FDG PET/CT scanning for staging which was available to the central review panel for quantitative analysis...
June 7, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Seo-Yeon Ahn, Seong Young Kwon, Sung-Hoon Jung, Jae-Sook Ahn, Su Woong Yoo, Jung-Joon Min, Hee-Seung Bom, So Yeon Ki, Hyeoung-Joon Kim, Je-Jung Lee, Sang Yun Song, Deok-Hwan Yang
PURPOSE: Primary central nervous system lymphoma (PCNSL) has a poor prognosis. There has been limited study evaluating the role of interim PET/CT in PCNSL. This prospective study investigated the interim response using sequential brain PET/CT with C-methionine (C-MET) to provide prognostic information during the treatment of PCNSL. MATERIALS AND METHODS: A total of 26 immunocompetent patients recently diagnosed with PCNSL were evaluated. Brain MRI and C-MET PET/CT were performed at the time of diagnosis and after 4 cycles of high-dose methotrexate-based induction chemotherapy...
June 5, 2018: Clinical Nuclear Medicine
E Incerti, S Broggi, A Fodor, M Cuzzocrea, A M Samanes Gajate, P Mapelli, C Fiorino, I Dell'Oca, M Pasetti, M Cattaneo, R Calandrino, L Gianolli, N Di Muzio, Maria Picchio
PURPOSE: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. METHODS: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max ), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%)...
June 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Weiyan Zhou, Jianbo Wen, Fengchun Hua, Weixingzi Xu, Xiuhong Lu, Bo Yin, Daoying Geng, Yihui Guan
OBJECTIVES: 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is useful for the detection of cancerous lesions, and FDG uptake is related to the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of extracranial tumors. The purpose of our study was to investigate the ability of FDG PET/CT in distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma multiforme (GBM) and to explore the relationship between 18 F-FDG uptake and the ADC in patients with PCNSL...
July 2018: European Journal of Radiology
Joon Ho Choi, Ilhan Lim, Woo Chul Noh, Hyun-Ah Kim, Min-Ki Seong, Seonah Jang, Hyesil Seol, Hansol Moon, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
OBJECTIVE: The aim of this study is to assess tumor differentiation using parameters from sequential positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) in patients with breast cancer. METHODS: This retrospective study included 78 patients with breast cancer. All patients underwent sequential PET/CT and MRI. For fluorodeoxyglucose (FDG)-PET image analysis, the maximum standardized uptake value (SUVmax ) of FDG was assessed at both 1 and 2 h and metabolic tumor volume (MTV) and total lesion glycolysis (TLG)...
May 23, 2018: Annals of Nuclear Medicine
Isabella Raccagni, Sara Belloli, Silvia Valtorta, Alessandro Stefano, Luca Presotto, Claudio Pascali, Anna Bogni, Monica Tortoreto, Nadia Zaffaroni, Maria Grazia Daidone, Giorgio Russo, Emilio Bombardieri, Rosa Maria Moresco
RATIONALE: Pathological response to neo-adjuvant chemotherapy (NAC) represents a commonly used predictor of survival in triple negative breast cancer (TNBC) and the need to identify markers that predict response to NAC is constantly increasing. Aim of this study was to evaluate the potential usefulness of PET imaging with [18F]FDG and [18F]FLT for the discrimination of TNBC responders to Paclitaxel (PTX) therapy compared to the response assessed by an adapted Response Evaluation Criteria In Solid Tumors (RECIST) criteria based on tumor volume (Tumor Volume Response)...
2018: PloS One
Shuai Liu, Zheng Feng, Zhaoxia Jiang, Hao Wen, Junyan Xu, Herong Pan, Yu Deng, Lei Zhang, Xingzhu Ju, Xiaojun Chen, Xiaohua Wu
OBJECTIVE: This study aimed to explore the clinical and prognostic significance of pretreatment positron-emission tomography/computed tomography (PET/CT) parameters, especially 2-deoxy-2-(F)fluoro-D-glucose-based heterogeneity, in high-grade serous ovarian cancer (HGSC). MATERIALS AND METHODS: We retrospectively investigated 56 patients with HGSC who underwent PET/CT before primary surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy...
May 16, 2018: Nuclear Medicine Communications
M Wuehr, C Schlick, K Möhwald, R Schniepp
INTRODUCTION: Primary orthostatic tremor (OT) is characterized by high-frequency lower limb muscle contractions and a disabling sense of unsteadiness while standing. To date, therapeutic options for OT are limited. Here, we examined the effects of proprioceptive leg muscle stimulation via muscle tendon vibration (MTV) on tremor and balance control in patients with primary OT. METHODS: Tremor in nine patients with primary OT was examined during four conditions: standing (1), standing with MTV on the bilateral soleus muscles (2), lying (3), and lying with MTV (4)...
May 16, 2018: Journal of Neurology
Lotte Nygård, Marianne C Aznar, Barbara M Fischer, Gitte F Persson, Charlotte B Christensen, Flemming L Andersen, Mirjana Josipovic, Seppo W Langer, Andreas Kjær, Ivan R Vogelius, Søren M Bentzen
We measured the repeatability of FDG PET/CT uptake metrics when acquiring scans in free breathing (FB) conditions compared with deep inspiration breath hold (DIBH) for locally advanced lung cancer. Twenty patients were enrolled in this prospective study. Two FDG PET/CT scans per patient were conducted few days apart and in two breathing conditions (FB and DIBH). This resulted in four scans per patient. Up to four FDG PET avid lesions per patient were contoured. The following FDG metrics were measured in all lesions and in all four scans: Standardized uptake value (SUV)peak , SUVmax , SUVmean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG), based on an isocontur of 50% of SUVmax ...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Aatif Parvez, Noam Tau, Douglas Hussey, Manjula Maganti, Ur Metser
PURPOSE: To determine whether metabolic tumor parameters and radiomic features extracted from 18 F-FDG PET/CT (PET) can predict response to therapy and outcome in patients with aggressive B-cell lymphoma. METHODS: This institutional ethics board-approved retrospective study included 82 patients undergoing PET for aggressive B-cell lymphoma staging. Whole-body metabolic tumor volume (MTV) using various thresholds and tumor radiomic features were assessed on representative tumor sites...
May 12, 2018: Annals of Nuclear Medicine
Rosario Mazzola, Sergio Fersino, Pierpaolo Alongi, Gioacchino Di Paola, Fabiana Gregucci, Dario Aiello, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVE: To investigate metabolic parameters as predictive of local response after stereotactic body radiation therapy (SBRT) for liver-oligometastases. METHODS: Inclusion criteria of the present retrospective study were: (a) liver oligometastases with controlled primary tumor; (b) absence of progressive disease ≥6 months; (c) metastases ≤ 3; (d) evaluation of SBRT-response by means of 18-fludeoxyglucose-PET/CT for at least two subsequent evaluations; (e) Karnofsky performance status >80; (f) life-expectancy >6 months...
May 23, 2018: British Journal of Radiology
Bert-Ram Sah, Christian A Leissing, Gaspar Delso, Edwin E Ter Voert, Stefan Krieg, Sebastian Leibl, Paul M Schneider, Cäcilia S Reiner, Martin W Hüllner, Patrick Veit-Haibach
BACKGROUND: Positron emission tomography (PET) / computed tomography (CT) is among the most frequently used imaging modalities for initial staging of gastro-oesophageal (GE) cancer, whereas CT-perfusion (CTP) provides different multiparametric information. This proof of concept study compares CTP- and PET-parameters in patients with GE cancer to evaluate correlations and a possible prognostic value of a combined PET/CTP imaging procedure. METHODS: A total of 31 patients with F-18-FDG-PET/CT and CTP studies were prospectively analysed...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Yasunori Masuike, Mitsuaki Tatsumi, Masaaki Motoori, Yutaka Kimura, Jun Hatazawa, Masaki Mori, Yuichiro Doki
OBJECTIVE: Here, we assess the ability of metabolic tumor volume (MTV) as measured by F-fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) to evaluate neoadjuvant chemotherapy response for patients with locally advanced esophageal cancer (EC). BACKGROUND: Optimal methods to evaluate treatment response for EC patients have not yet been established. Although previous studies have reported the value of standardized uptake value (SUV), the accuracy of predicting histological response or long-term survival in EC is limited...
May 1, 2018: Annals of Surgery
Julian M M Rogasch, Patrick Hundsdoerfer, Frank Hofheinz, Florian Wedel, Imke Schatka, Holger Amthauer, Christian Furth
BACKGROUND: Standardized treatment in pediatric patients with Hodgkin's lymphoma (HL) follows risk stratification by tumor stage, erythrocyte sedimentation rate and tumor bulk. We aimed to identify quantitative parameters from pretherapeutic FDG-PET to assist prediction of response to induction chemotherapy. METHODS: Retrospective analysis in 50 children with HL (f:18; m:32; median age, 14.8 [4-18] a) consecutively treated according to EuroNet-PHL-C1 (n = 42) or -C2 treatment protocol (n = 8)...
May 3, 2018: BMC Cancer
Luca Ceriani, Lisa Milan, Maurizio Martelli, Andrés J M Ferreri, Luciano Cascione, Pier Luigi Zinzani, Alice Di Rocco, Annarita Conconi, Anastasios Stathis, Franco Cavalli, Monica Bellei, Kelly Cozens, Elena Porro, Luca Giovanella, Peter W Johnson, Emanuele Zucca
An important unmet need in the management of primary mediastinal B-cell lymphoma (PMBCL) is to identify the patients for whom first line therapy will fail, in order to intervene before the lymphoma becomes refractory. High heterogeneity of intratumoral 18F-fluorodeoxyglucose (18FDG) uptake distribution on positron emission tomography/computed tomography (PET/CT) scans has been suggested as a possible marker of chemo-resistance in solid tumors. In the present study, we investigated the prognostic value of metabolic heterogeneity (MH) in 103 PMBCL patients prospectively enrolled in the International Extranodal Lymphoma Study Group (IELSG) 26 study, aimed at clarifying the role of PET in this lymphoma subtype...
May 2, 2018: Blood
Emi Yamaga, Akira Toriihara, Shin Nakamura, Sakurako Asai, Tomoyuki Fujioka, Ryoichi Yoshimura, Yasuyuki Michi, Hiroyuki Harada, Ukihide Tateishi
Background: Positron emission tomography with 2-deoxy-2-[18F] fluoro-d-glucose integrated with computed tomography (FDG-PET/CT) is a useful method to evaluate patients with oral squamous cell carcinoma (OSCC). However, the prognostic significance of FDG-PET/CT for assessing early OSCC remains unclear. Methods: Pretreatment FDG-PET/CT of 205 consecutive patients (125 men, 80 women, mean age 59.7 year old) with early OSCC (cT1-2N0M0) between June 2010 and December 2014 were retrospectively analyzed...
April 28, 2018: Japanese Journal of Clinical Oncology
Kempland C Walley, Tyler A Gonzalez, Ryan Callahan, Aubree Fairfull, Evan Roush, Kaitlin L Saloky, Paul J Juliano, Gregory S Lewis, Michael C Aynardi
BACKGROUND: Evaluation and management of osteochondral lesions of the talus (OLTs) often warrant advanced imaging studies, especially in revision or cases with cystic defects. It is possible that orthopedic surgeons may overestimate the size and misinterpret the morphology of OLT from conventional computed tomography (CT), thereby influencing treatment strategies. The purpose of this study was to determine the utility of a novel means to estimate the true-volume of OLTs using 3D reconstructed images and volume analysis...
April 1, 2018: Foot & Ankle International
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