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Li Yang, Yufeng Wu, Hong Tang, Jiuzhou Zhao, Dongdong Zhao, Sen Yang, Qiming Wang
Objective: The purpose of this article is to explore the targeted treatment of malignant myofibroblastoma and evaluate the role of neoplasm metabolite markers in the evaluation of efficacy after targeted therapy. Method: This report described a case of myofibroblastic sarcoma with rare mutation of ALK R401 in a 58-year-old man prescribed with crizotinib, to evaluate its curative effect by positron emission tomography coupled with computed tomography (PET-CT). After the progressive disease in the brain, bevacizumab combined with crizotinib was administered...
2018: OncoTargets and Therapy
Berna A Yildirim, Nese Torun, Ozan C Guler, Cem Onal
PURPOSE: The aim of this study was to evaluate the prognostic importance metabolic tumor volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) in patients with esophageal cancer treated with definitive chemoradiotherapy. PATIENTS AND METHODS: Seventy-two esophageal cancer patients treated with definitive chemoradiotherapy [57 (79%) patients] or definitive radiotherapy [15 (21%) patients] were retrospectively analyzed. The regions equal to or greater than SUV of 2...
April 17, 2018: Nuclear Medicine Communications
Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi, Shinji Uemoto
BACKGROUND: Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. This study aimed to identify clinical prognostic indicators by investigating the molecular profiles of ICC and evaluating the preoperative imaging data of 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET)...
April 11, 2018: Journal of Translational Medicine
Chen Wang, Xin Zhang, Xue Yang, Hui Li, Ruixue Cui, Wenmin Guan, Xin Li, Zhaohui Zhu, Yansong Lin
This work evaluated the use of the positron emission tomography/computed tomography (PET/CT) technique to assess the early therapeutic response and predict the prognosis of patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) who underwent apatinib therapy. Standardised uptake value (SUV), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), derived from 18FDG PET/CT and SUV from 68Ga-NOTA-PRGD2 PET/CT, were evaluated. Tumour response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) 1...
April 4, 2018: Endocrine-related Cancer
Yanping Ren, Yuxin Jiao, Weiqiang Ge, Libo Zhang, Yanqing Hua, Cheng Li, Weihao Zhai, Xi Tang, Wei He, Min Fang, Xiangpeng Zheng
OBJECTIVE: The objective of this study was to investigate the correlation between dual-energy computed tomography (DECT)-based iodine quantitation and fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for response evaluation of lung cancers to treatment. METHODS: In this prospective study, a total of 32 pairs of DECT and F-FDG PET/CT imaging acquired consecutively from 13 patients with primary or metastatic lung cancers receiving either radiotherapy alone or chemoradiotherapy were analyzed...
April 2, 2018: Journal of Computer Assisted Tomography
Maria A Velez, Darlene Veruttipong, Pin-Chieh Wang, Elliot Abemayor, Maie St John, Mindi TenNapel, Allen M Chen
OBJECTIVE: The utility of fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to predict outcome has been well-established for patients undergoing definitive radiation in the initial management of head and neck cancer. However, the usefulness of this modality in the recurrent setting remains uncertain. We sought to evaluate the prognostic value of metabolic tumor parameters measured on FDG-PET in patients treated by reirradiation for recurrent head and neck cancer. METHODS: Thirty-four tumors occurring in 29 patients were reirradiated and were evaluable...
March 24, 2018: Laryngoscope
Soichi Odawara, Kazuhiro Kitajima, Takayuki Katsuura, Yasunori Kurahashi, Hisashi Shinohara, Koichiro Yamakado
PURPOSE: We compared the response classification systems Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) 1.0 for assessment of response to neoadjuvant chemotherapy in patients with esophageal cancer. MATERIALS AND METHODS: Prior to planned surgical resection, 62 patients with esophageal cancer underwent fluorodeoxyglucose (FDG)-PET/CT and contrast-enhanced CT examinations before and after receiving neoadjuvant chemotherapy...
April 2018: European Journal of Radiology
Hongxi Wang, Guohua Shen, Chong Jiang, Li Li, Futao Cui, Rong Tian
METHODS: We searched the PubMed, EMBASE, Cochrane Library and Medline databases for eligible articles. SUVmax, MTV, and TLG on B-PET/CT, DS on I-PET/CT and DS on E-PET/CT were regarded as efficacy data. Combined hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were estimated using RevMan 5.3 software. RESULTS: Nine trials with a total of 535 ENKTL patients were included. SUVmax, MTV and TLG on B-PET/CT were significantly associated with PFS with HRs of 2...
2018: PloS One
B Serrano Falcón, M Megía Sánchez, A Ruiz de León, E Rey
BACKGROUND: Beer has been related to gastroesophageal reflux (GER) and dyspepsia, based on its alcohol and gas content. The aim of this study is to evaluate the association between moderate consumption of traditional and alcohol-free beer and upper digestive symptoms, gastric accommodation and GER. METHODS: Healthy adults without frequent gastrointestinal symptoms and GER disease were included. The intervention involved administration of traditional beer to 10 subjects (substudy 1) and alcohol-free beer to 20 (substudy 2); control intervention entailed administration of water...
March 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Mohamed A Hammoud, Stefanie Vaccher, Fengyi Jin, Adam Bourne, Bridget Haire, Lisa Maher, Toby Lea, Garrett Prestage
INTRODUCTION: Gay and bisexual men (GBM) often use illicit drugs to enhance sexual pleasure, commonly referred to as 'chemsex' or 'party n play'. In particular, the use of methamphetamine and Viagra™, and other erectile dysfunction medications, both together and separately are strongly predictive of subsequent HIV infection. Truvada™, as pre-exposure prophylaxis (PrEP), virtually eliminates HIV transmission during condomless anal intercourse (CLAI). HIV-negative GBM in intensive sex partying networks may be adding PrEP to their drug regimen to actively reduce the possibility of HIV transmission during chemsex...
March 8, 2018: International Journal on Drug Policy
Huazheng Shi, Zuguo Yuan, Zheng Yuan, Chunshan Yang, Jian Zhang, Yi Shou, Wenrui Zhang, Zhaofu Ping, Xin Gao, Shiyuan Liu
Objective: To assess clinical value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for differentiation of malignant from benign focal thyroid incidentaloma. Materials and Methods: This retrospective study included 99 patients with focal thyroid incidentaloma of 5216 non-thyroid cancer patients that had undergone PET/CT. PET/CT semi-quantitative parameters, volume-based functional parameters, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of thyroid incidentaloma were assessed...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Philippe Robin, David Bourhis, Brieuc Bernard, Ronan Abgral, Solène Querellou, Alexandra Le Duc-Pennec, Pierre-Yves Le Roux, Pierre-Yves Salaün
Objective: Respiratory motion in18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) induces blurred images, leading to errors in location and quantification for lung and abdominal lesions. Various methods have been developed to correct for these artifacts, and most of current PET/CT scanners are equipped with a respiratory gating system. However, they are not routinely performed because their use is time-consuming. The aim of this study is to assess the feasibility and quantitative impact of a systematic respiratory-gated acquisition in unselected patients referred for FDG PET/CT, without increasing acquisition time...
2018: Frontiers in Medicine
Soyoung Kim, Dongwoo Kim, Se Hoon Kim, Mi-Ae Park, Jong Hee Chang, Mijin Yun
PURPOSE: This prospective study aimed to evaluate the clinical values of11 C-acetate positron emission tomography/computed tomography (PET/CT) in predicting histologic grades and survival in patients with cerebral glioma. METHODS: Seventy-three patients with surgically confirmed cerebral gliomas (19 grade II, 21 grade III, and 33 grade IV) who underwent11 C-acetate PET/CT before surgery were included. Tumor-to-choroid plexus ratio (TCR), which was defined as the maximum standardized uptake value (SUV) of tumors to the mean SUV of choroid plexus, was compared between three World Health Organization (WHO) grade groups...
March 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Jeong-Won Lee, Jeong-Yeol Park, Hyun Ju Lee, Jong Jin Lee, Seung Hwan Moon, Seo Young Kang, Gi Jeong Cheon, Hyun Hoon Chung
PURPOSE: We investigated the prognostic value of the tumour heterogeneity index determined on preoperative [18 F]FDG PET/CT in patients with uterine leiomyosarcoma (LMS). METHODS: We retrospectively reviewed patients with uterine LMS who underwent preoperative [18 F]FDG PET/CT scans at three tertiary referral hospitals. The PET/CT parameters maximum standardized uptake value of the primary tumour (SUVmax ), metabolic tumour volume (MTV) and total lesion glycolysis were assessed...
February 28, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Marius E Mayerhoefer, Markus Raderer, Ulrich Jaeger, Philipp Staber, Barbara Kiesewetter, Daniela Senn, Ferdia A Gallagher, Kevin Brindle, Edit Porpaczy, Michael Weber, Dominik Berzaczy, Ingrid Simonitsch-Klupp, Christian Sillaber, Cathrin Skrabs, Alexander Haug
PURPOSE: To determine whether, in patients with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL), [18 F]FDG PET/MR can capture treatment effects within the first week after treatment initiation, and whether changes in glucose metabolism and cell density occur simultaneously. METHODS: Patients with histologically proven HL or NHL were included in this prospective IRB-approved study. Patients underwent [18 F]FDG PET/MR before, and then 48-72 h after (follow-up 1, FU-1) and 1 week after (FU-2) initiation of the first cycle of their respective standard chemotherapy (for HL) or immunochemotherapy (for NHL)...
February 26, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Tuulia Vallius, Johanna Hynninen, Jukka Kemppainen, Victor Alves, Kari Auranen, Jaakko Matomäki, Sinikka Oksa, Johanna Virtanen, Seija Grénman, Annika Auranen, Marko Seppänen
OBJECTIVE: To evaluate the predictive potential of total metabolic tumor volume (MTV) reduction during neoadjuvant chemotherapy (NACT) with18 F-FDG-PET/CT in an advanced FIGO stage III/IV epithelial ovarian cancer (EOC) patient cohort. METHODS: Twenty-nine primarily inoperable EOC patients underwent18 F-FDG-PET/CT before and after NACT. The pre- and post-NACT total MTV, in addition to the percentage MTV reduction during NACT, were compared with primary therapy outcome and progression-free survival (PFS)...
February 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Baderaldeen A Altazi, Daniel C Fernandez, Geoffrey G Zhang, Samuel Hawkins, Syeda M Naqvi, Youngchul Kim, Dylan Hunt, Kujtim Latifi, Matthew Biagioli, Puja Venkat, Eduardo G Moros
Quantitative image features, also known as radiomic features, have shown potential for predicting treatment outcomes in several body sites. We quantitatively analyzed18 Fluorine-fluorodeoxyglucose (18 F-FDG) Positron Emission Tomography (PET) uptake heterogeneity in the Metabolic Tumor Volume (MTV) of eighty cervical cancer patients to investigate the predictive performance of radiomic features for two treatment outcomes: the development of distant metastases (DM) and loco-regional recurrent disease (LRR). We aimed to fit the highest predictive features in multiple logistic regression models (MLRs)...
February 20, 2018: Physica Medica: PM
Hajira Ilyas, N George Mikhaeel, Joel T Dunn, Fareen Rahman, Henrik Møller, Daniel Smith, Sally F Barrington
PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into 'low' versus 'high' MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consecutive unselected patients with DLBCL, different software algorithms and published methods of MTV measurement using FDG PET. METHOD: Pretreatment MTV was measured on 147 patients treated at Guy's and St Thomas' Hospital...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
S Medina-Ornelas Sevastián, O García-Pérez Francisco, Y Hernández-Pedro Norma, E Arellano-Zarate Angélica, L Abúndiz-López Blanca
OBJECTIVE: To investigate the association between prostatic-specific antigen (PSA) levels and molecular tumor volume (MTV) measured in the68 Ga-PSMA PET/CT, both done in a short period of time, in prostate cancer patients with biochemical failure. METHODS: Eighty-four patients who underwent68 Ga-PSMA PET/CT and measurement of PSA levels in the same week (trigger-PSA) were studied in this retrospective analysis. MTV was calculated from the sum of the metastatic lesions...
February 14, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Su Yeon Ahn, Jin Mo Goo, Kyung Hee Lee, Seunggyun Ha, Jin Chul Paeng
OBJECTIVES: To determine whether the CKD-516 produces a significant change in vascular and metabolic parameters in PET/MRI. MATERIALS AND METHODS: With institutional Animal Care and Use Committee approval, 18 VX2 carcinoma tumors implanted in bilateral back muscles of 9 rabbits were evaluated. Serial PET/MRI were performed before, 4 hours after and 1-week after vascular disrupting agent, CKD-516 at a dose of 0.7 mg/kg (treated group, n = 10) or saline (control group, n = 8) administration...
2018: PloS One
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