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https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#1
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29771870/hyperfibrinolysis-is-an-important-cause-of-early-hemorrhage-in-patients-with-acute-promyelocytic-leukemia
#2
Yu-Hua Song, Chun Qiao, Li-Chan Xiao, Run Zhang, Hua - Lu
BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with APL during induction treatment. RESULTS The early death (ED) rate in our study was 5.36% and the main cause was fetal hemorrhage. The presence of bleeding symptoms was significantly correlated with low platelet and fibrinogen levels...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29756268/does-rotational-thromboelastometry-accurately-predict-coagulation-status-in-patients-with-lupus-anticoagulant
#3
L Hensch, V Kostousov, K Bruzdoski, M Losos, M Pereira, M de Guzman, S Hui, J Teruya
INTRODUCTION: Rotational thromboelastometry (ROTEM) is increasingly used as a tool for monitoring coagulation status. However, ROTEM is susceptible to misinterpretation due to particular coagulation abnormalities. Here, we report the effects of lupus anticoagulant (LA) on ROTEM. METHODS: A prospective observational analysis was performed on 16 children with prior studies indicating the presence of LA or antiphospholipid antibodies. ROTEM analysis was performed, and samples were further analyzed by adding phospholipids (PL) to repeat ROTEM analysis if clotting time (CT) abnormalities were discovered with comparison to ROTEM using an equal volume of isotonic saline...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29741463/influence-of-needle-gauge-used-for-venipuncture-on-measures-of-hemostasis-in-cats
#4
Susanna Solbak, Steven E Epstein, Kate Hopper
Objectives The objective of this study was to evaluate the effect of different needle sizes used to obtain blood via jugular venipuncture in cats on routine measures of hemostasis. Methods This was a prospective, observational, randomized, clinical study carried out at a university teaching hospital. Twenty healthy, client-owned cats were used. Results Each cat had blood collected via direct venipuncture from both jugular veins. Sampling of the right and left jugular vein was randomized to be collected with either a 22 G or a 25 G needle, respectively, and routine coagulation variables and platelet count were performed on all samples...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29737836/intelligent-mno2-cu2-xs-for-multimode-imaging-diagnostic-and-advanced-single-laser-irradiated-photothermal-photodynamic-therapy
#5
Yu Cao, Xiangdan Meng, Dongdong Wang, Kai Zhang, Wenhao Dai, HaiFeng Dong, Xueji Zhang
Lately, photothermal therapy (PTT) and photodynamic therapy (PDT) dual-modal therapy has attracted much attention in cancer therapy as a synergistic therapeutic model. However, the integration of PDT and PTT in single nanoagent for cancer therapy is still a challenging task. Herein, an intelligent MnO2/Cu2-xS-siRNA nanoagent simultaneously overcoming inherent limitations of PDT and PTT with remarkable PTT/PDT therapeutic efficiency enabling multimode accurate tumor imaging diagnostic is designed. We first develop a general method to decorate Cu2-xS on the surface of MnO2 nanosheet (MnO2/Cu2-xS), then, it was loaded with heat shock protein (HSP) 70 siRNA to obtain MnO2/Cu2-xS-siRNA...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29730743/the-clinical-impact-of-edoxaban-for-the-patients-with-postoperative-anemia-after-total-hip-arthroplasty
#6
Yasuhisa Izushi, Naofumi Shiota, Tomonori Tetsunaga, Kenichi Shimada, Takashi Egawa, Tsukasa Kiuchi, Toru Sato, Ritsugi Takuma, Yoichiro Takami
BACKGROUND: Postoperative anemia is a common complication after total hip arthroplasty (THA). However, the effect of edoxaban on postoperative anemia after THA remains unclear. Here, we retrospectively evaluated the clinical assessment of postoperative anemia and the associated changes of coagulation parameters in patients undergoing thromboprophylaxis with edoxaban compared with fondaparinux as a conventional anticoagulant thromboprophylactic agent after THA. METHODS: One hundred and forty-nine patients who underwent THA from July 2010 to June 2012 were divided into two groups, according to whether they were operated on before or after the approval of edoxaban: the fondaparinux group (Group F: 86 patients) and the edoxaban group (Group E: 63 patients)...
May 5, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29708302/congenital-dysfibrinogenaemia-assessed-by-whole-blood-thromboelastography
#7
A Wei, L Liao, L Xiang, J Yan, W Yang, G Nai, M Luo, D Deng, F Lin
INTRODUCTION: Congenital dysfibrinogenaemia (CD) is a rare hereditary blood disorder, and thromboelastography (TEG) can comprehensively assess the clotting function of patients. However, only few studies have focussed on the application of TEG in CD. We aim to investigate the clinical value of TEG in congenital CD. METHODS: We performed TEG and routine coagulation tests, including plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), functional fibrinogen (Fg) concentration (Clauss method) and Fg concentration (PT-derived method) tests, in 17 patients with CD (experimental group) and 28 healthy individuals (control group)...
April 30, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29688391/evaluating-a-mobile-application-for-improving-clinical-laboratory-test-ordering-and-diagnosis
#8
Ashley N D Meyer, Pamela J Thompson, Arushi Khanna, Samir Desai, Benji K Mathews, Elham Yousef, Anita V Kusnoor, Hardeep Singh
Objective: Mobile applications for improving diagnostic decision making often lack clinical evaluation. We evaluated if a mobile application improves generalist physicians' appropriate laboratory test ordering and diagnosis decisions and assessed if physicians perceive it as useful for learning. Methods: In an experimental, vignette study, physicians diagnosed 8 patient vignettes with normal prothrombin times (PT) and abnormal partial thromboplastin times (PTT)...
April 20, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29685415/preoperative-assessment-of-haemostasis-in-patients-undergoing-stereotactic-brain-biopsy
#9
Christopher Beynon, Shilai Wei, Alexander Radbruch, David Capper, Andreas W Unterberg, Karl L Kiening
Parenchymal hemorrhage is considered a major risk factor for perioperative morbidity in patients undergoing stereotactic brain biopsy. Studies on patients undergoing surgical procedures have suggested that evaluation of prothrombin time (PT) and activated partial thromboplastin time (aPTT) is of limited value with regard to prevention of haemorrhagic complications. However, this issue has not yet been addressed in patients undergoing stereotactic biopsy of intracranial lesions. We retrospectively analysed the medical records of 159 consecutive patients undergoing stereotactic biopsy of supratentorial intracranial lesions during a three-year period...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29669440/thrombin-generation-assay-detects-moderate-intensity-statin-induced-reduction-of-hypercoagulability-in-diabetes
#10
Hee Sue Park, Ja-Yoon Gu, Hyun Ju Yoo, Se Eun Han, Chan Ho Park, Young Il Kim, Il Sung Nam-Goong, Eun Sook Kim, Hyun Kyung Kim
Statins not only have a lipid-lowering effect but also reduce inflammation and have an antithrombotic effect. Since hypercoagulability assessed by thrombin generation assay (TGA) and increased formation of neutrophil extracellular traps (NET) were demonstrated in diabetes, we investigated whether statin therapy in diabetes modifies coagulation status and NET formation. Twenty-five consecutive patients with diabetes were recruited. Global coagulation assays (prothrombin time [PT], activated partial thromboplastin time [aPTT], and TGA) and NET markers (DNA-histone complex, cell-free DNA, and neutrophil elastase) were measured before and after 3-month moderate-intensity statin therapy...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29656962/treatment-of-platelet-concentrates-and-plasma-with-riboflavin-and-uv-light-impact-in-bacterial-reduction
#11
J M Bello-López, L Delgado-Balbuena, D Rojas-Huidobro, J Rojo-Medina
OBJECTIVES: Transfusion of hemocomponents is essential for clinical and surgical procedures and therefore their safety has increased. An option for pathogen reduction includes the combination of riboflavin and UV light. To our knowledge, there are no studies in Latin America that demonstrate the effectiveness of the pathogen reduction in hemocomponents. The objective of this work was to evaluate the efficiency of a pathogens reduction system in platelets concentrates (PC) and plasma. MATERIALS AND METHODS: PC and plasma were contaminated with Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes and Staphylococcus epidermidis at 104 to 106  CFU and subjected to bacterial reduction...
April 12, 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29652992/-phenotypic-and-mutational-analysis-of-a-pedigree-affected-with-hereditary-coagulation-factor-%C3%A2-deficiency
#12
Mengcha Tian, Hong Xia, Zhishan Zhang, Yanhui Jin, Kankan Su, Mingshan Wang
OBJECTIVE: To explore the molecular pathogenesis for a pedigree affected with coagulation factor Ⅴ (FⅤ) deficiency. METHODS: Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), coagulation factor Ⅱ activity (FⅡ: C), FⅤ activity (FⅤ: C), coagulation factor Ⅶ activity (FⅦ: C), and coagulation factor Ⅹ activity (FⅩ: C) were determined with a STAGO automatic coagulometer. FⅤ antigen (FⅤ: Ag) was detected with enzyme linked immunosorbent assay (ELISA)...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652987/-analysis-of-a-pedigree-affected-with-congenital-hypofibrinogenemia-due-to-heterozygous-ser313ile-mutation-of-fibrinogen-%C3%AE-chain-gene
#13
Liqing Zhu, Misheng Zhao, Xiaoli Cheng, Dandan Yu, Xiaolong Li, Fei Xu, Jinguo Wang, Mingshan Wang
OBJECTIVE: To explore the genetic basis for a Chinese pedigree affected with congenital hypofibrinogenamia. METHODS: Peripheral blood samples were collected from 9 members from the pedigree. Routine coagulation tests including activated partial thromboplastin time (APTT), thrombin time (TT), the prothrombin time (PT) were carried out. The activity of fibrinogen (Fg: C) was measured using Clauss method, and fibrinogen antigen (Fg: Ag) was measured with immunoturbidimetry...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29648994/within-subject-biological-variation-of-activated-partial-thromboplastin-time-prothrombin-time-fibrinogen-factor-viii-and-von-willebrand-factor-in-pregnant-women
#14
Ann Helen Kristoffersen, Per Hyltoft Petersen, Line Bjørge, Thomas Røraas, Sverre Sandberg
BACKGROUND: During pregnancy, interpretation of results from coagulation parameters can be difficult as the physiological changes that occur may affect the biochemical parameters. The aim of this study was to describe the normal course of five coagulation parameters in healthy pregnancies, and to estimate the within-subject biological variation (CVI). METHODS: Blood samples were obtained every 4th week during pregnancy and three samples after delivery in 20 healthy women and every 4th week during a 40-week period in 19 healthy non-pregnant women...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29643709/delayed-formation-of-hematomas-with-ethanol-preconditioning-in-experimental-intracerebral-hemorrhage-rats
#15
Hung-Yu Cheng, Li-Chuan Huang, Hsiao-Fen Peng, Jon-Son Kuo, Hock-Kean Liew, Cheng-Yoong Pang
Objective: Spontaneous intracerebral hemorrhage (ICH) accounts for 10%-15% of all strokes and causes high mortality and morbidity. In the previous study, we demonstrated that ethanol could aggravate the severity of brain injury after ICH by increasing neuroinflammation and oxidative stress. In this study, we further investigate the acute effects of ethanol on brain injury within 24 h after ICH. Materials and Methods: Totally, 66 male Sprague-Dawley rats were assigned randomly into two groups: saline pretreatment before ICH (saline + ICH), and ethanol pretreatment before ICH (ethanol + ICH)...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29626437/dynamic-reference-intervals-for-coagulation-parameters-from-infancy-to-adolescence
#16
Christina Weidhofer, Meyer Elias, Ristl Robin, Helmut Wiedemann, Janne Cadamuro, Kipman Ulrike, Jakob Zierk, Christoph Male, Peter Quehenberger, Elisabeth Haschke-Becher, Elisa Einwallner
INTRODUCTION: Practical and ethical challenges as well as time and costs have restricted the generation of pediatric reference intervals. Therefore, pediatric reference intervals on coagulation parameters based on solid evidence are still scarce. Furthermore, reference intervals by age-group cannot reflect the dynamics of age and sex specific coagulation values during childhood. This study is the first to close this gap and provide continuous age and sex dependent reference intervals during childhood in hemostasis...
April 4, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29623883/evaluation-of-the-coagulometer-sta-r-max-%C3%A2-stago-for-routine-coagulation-parameters
#17
Justine Brulé, Thomas Sinegre, Bruno Pereira, Marc G Berger, Anne-Françoise Serre-Sapin, Aurélien Lebreton
The STA R Max® is a fully automated multiparameter coagulometer using clotting (viscosity-based detection system), chromogenic and immunologic assays. STA R Max® is equipped with an innovative software (STA Coag Expert® ) designed to assist laboratory in accreditation. The aim of this study was to evaluate its performances for the certification according to ISO 15189 quality standard in the haemostasis unit of our university hospital. The following tests were evaluated: prothrombin time (PT), activated partial thromboplastin time (aPTT), kaolin cephalin clotting time (KCCT), fibrinogen, anti-Xa assay and D-dimers...
April 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29622820/high-risk-of-coagulopathy-among-type-2-diabetes-mellitus-clients-at-a-municipal-hospital-in-ghana
#18
Richard Kd Ephraim, Yaw A Awuku, Patrick Adu, Lord Tw Ampomah, Prince Adoba, Solomon Panford, Jerry Pk Ninnoni, Hope Agbodzakey
Background: Persistent hyperglycaemia in diabetes mellitus causes coagulopathies due to glycation of haemoglobin, prothrombin, fibrinogen and other proteins involved in the clotting mechanism. Shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) reflect hypercoagulable state, which is associated with an increased thrombotic risk and adverse cardiovascular effects. This study assessed the coagulation profile of type 2 diabetes mellitus (T2DM) clients at a municipal hospital in Ghana...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29611057/a-discrepancy-between-prothrombin-time-and-normotest-hepaplastintest-results-is-useful-for-diagnosis-of-acquired-factor-v-inhibitors
#19
Yasuko Kadohira, Shinya Yamada, Tomoe Hayashi, Eriko Morishita, Hidesaku Asakura, Akitada Ichinose
Acquired coagulation factor inhibitors are rare. Among them, coagulation factor V (FV) inhibitor is particularly uncommon and presents with variable clinical manifestations. Certain acquired FV inhibitor patients have only mild bleeding or, in select cases, no symptoms at all, leading to spontaneous recovery. Others have life-threatening bleeding that requires medical attention. Thus, a prompt decision regarding diagnosis and clinical intervention is crucial for such patients. In five acquired FV inhibitor cases treated in our facility, each patient had a malignancy as an underlying disease and all unexpectedly showed prolongation of both prothrombin time (PT) and activated partial thromboplastin time (APTT)...
April 2, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29605959/heparin-induced-thrombocytopenia-in-infants-after-heart-surgery
#20
Juma N Abdillah, Qinghua Hu, Xuliang Chen, Xing Chen, Wu Zhou, Wanjun Luo, Lingjin Huang
BACKGROUND:  Heparin-induced thrombocytopenia (HIT) in infants is a rare disorder, and the diagnosis and management of HIT still remains challenging. Argatroban is a synthetic direct thrombin inhibitor (DTI) that is widely used for treating HIT. However, little is known about the efficacy of the activated clotting time (ACT) test in monitoring DTI treatment as an alternative to the routinely used activated partial thromboplastin time (aPTT). METHODS:  Between July 2013 and January 2015, four infants were diagnosed with HIT after surgical correction of congenital anomalies...
April 1, 2018: Thoracic and Cardiovascular Surgeon
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