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https://www.readbyqxmd.com/read/28819409/a-retrospective-discussion-of-the-prognostic-value-of-combining-prothrombin-time-pt-and-fibrinogen-fbg-in-patients-with-hepatocellular-carcinoma
#1
Xue-Ping Wang, Min-Jie Mao, Zhong-Lian He, Lin Zhang, Pei-Dong Chi, Jia-Rui Su, Shu-Qin Dai, Wan-Li Liu
Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value of pretreatment plasma coagulation tests in hepatocellular carcinoma (HCC) patients. Patient and methods: A retrospective study was performed in 539 patients with HCC, and follow-up period was at least 60 months until recurrence or death. The prognostic significance of coagulation system tests (prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen) were determined by univariate and multivariate Cox hazard models...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28817760/association-between-hypercoagulability-and-severe-obstructive-sleep-apnea
#2
Seung-No Hong, Hee-Chul Yun, Joon Hyuk Yoo, Seung Hoon Lee
Importance: Obstructive sleep apnea (OSA) is related to the increased risk of cardiovascular disease. Although the pathogenesis of this association remains unclear, an alteration in coagulability is suspected as a link. Objective: To investigate the association between the severity of OSA and blood coagulability. Design, Setting, and Participants: A retrospective cohort study conducted at a tertiary care university hospital evaluated 146 patients with OSA from January 1, 2009, to July 31, 2015...
August 17, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28814943/comparison-of-different-laboratory-tests-in-the-evaluation-of-hemorrhagic-risk-of-patients-using-rivaroxaban-in-the-critical-care-setting-diagnostic-accuracy-study
#3
Marjorie Paris Colombini, Priscilla Bento Matos Cruz Derogis, Valdir Fernandes de Aranda, João Carlos de Campos Guerra, Nelson Hamerschlak, Cristóvão Luis Pitangueiras Mangueira
BACKGROUND: Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in the critical care setting. METHODS: This is a diagnostic accuracy study evaluating sensitivity and specificity of prothrombin time (PT), activated partial thromboplastin time (aPTT), and Dilute Russell viper venom time (dRVVT), to evaluate the hemorrhagic risk in patients taking rivaroxaban...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28805299/dissociation-between-the-pharmacokinetics-and-pharmacodynamics-of-once-daily-rivaroxaban-and-twice-daily-apixaban-a-randomized-crossover-study
#4
Reinhold Kreutz, Pontus B Persson, Dagmar Kubitza, Kirstin Thelen, Stefan Heitmeier, Stephan Schwers, Michael Becka, Melanie Hemmrich
BACKGROUND: The anticoagulant actions of the oral direct factor Xa inhibitors, rivaroxaban and apixaban, have not previously been directly compared. OBJECTIVES: To compare directly the steady-state pharmacokinetics and anticoagulant effects of rivaroxaban and apixaban at doses approved for stroke prevention in nonvalvular atrial fibrillation. METHODS: Twenty-four healthy Caucasian male volunteers were included in this open-label, two-period crossover, phase 1 study (EudraCT number: 2015-002612-32)...
August 14, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28783419/effects-of-safflower-injection-on-the-pharmacodynamics-and-pharmacokinetics-of-warfarin-in-rats
#5
Yan Liu, Shuang Liu, Yuan Shi, Mengnan Qin, Zhidan Sun, Gaofeng Liu
1. Safflower injection (SI) is extracted from Chinese herbal medicine safflower which comprises many active components. Warfarin is a common anticoagulant and has exhibited drug interactions with several herbal products. This study aimed to investigate the effects of SI on pharmacodynamics and pharmacokinetics of warfarin in rats. 2. Wistar rats were randomly divided into blank control group, SI group, warfarin control group, and SI+warfarin group, respectively. In SI and SI+warfarin groups, rats were injected with SI (1...
August 7, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28775134/emergency-coagulation-assessment-during-treatment-with-direct-oral-anticoagulants-limitations-and-solutions
#6
Matthias Ebner, Ingvild Birschmann, Andreas Peter, Florian Härtig, Charlotte Spencer, Joachim Kuhn, Gunnar Blumenstock, Christine S Zuern, Ulf Ziemann, Sven Poli
BACKGROUND AND PURPOSE: In patients receiving direct oral anticoagulants (DOACs), emergency treatment like thrombolysis for acute ischemic stroke is complicated by insufficient availability of DOAC-specific coagulation tests. Conflicting recommendations have been published concerning the use of global coagulation assays for ruling out relevant DOAC-induced anticoagulation. METHODS: Four hundred eighty-one samples from 96 DOAC-treated patients were tested using prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT), DOAC-specific assays (anti-Xa activity, diluted TT), and liquid chromatography-tandem mass spectrometry...
August 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28773912/highly-absorbent-antibacterial-hemostatic-dressing-for-healing-severe-hemorrhagic-wounds
#7
Ting-Ting Li, Ching-Wen Lou, An-Pang Chen, Mong-Chuan Lee, Tsing-Fen Ho, Yueh-Sheng Chen, Jia-Horng Lin
To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel(®)/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. This study is the first to investigate the wicking and water-absorbing properties of a nonwoven base by measuring the vertical wicking height and water absorption ratio. Moreover, blood agglutination and hemostatic second tests were conducted to evaluate the hemostatic performance of the resultant wound dressing...
September 21, 2016: Materials
https://www.readbyqxmd.com/read/28766891/influences-of-argatroban-on-five-fibrinogen-assays
#8
L Zhang, J Yang, X Zheng, Q Fan, Z Zhang
INTRODUCTION: Argatroban, as a direct thrombin inhibitor, prolongs the clotting time. However, detection of clotting time is the base of routine fibrinogen assays, including Clauss method and derived method. The influences of argatroban on fibrinogen assays are still unclear. METHODS: Normal pooled plasma (NPP) from 20 healthy subjects was spiked with increasing argatroban concentrations (0-3.2 μg/mL). Then the NPP samples were analyzed by five fibrinogen assays: HemosIL Fibrinogen-C XL reagent (Clauss method) on ACL-TOP; STA-Fibrinogen reagent (Clauss method) on STA-R Evolution; Siemens Thrombin reagent (Clauss method) on CS-5100; SynthASil RecombiPlasTin 2G reagent (PT-derived method) on ACL-TOP; and N Antiserum to Human Fibrinogen reagent (NAHF, Immunoassay) on BN2 nephelometer analyzer...
August 2, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28764891/2-methoxyethylacrylate-modified-polysulfone-membrane-and-its-blood-compatibility
#9
Xin Tian, Yun-Ren Qiu
Hydrophilic material of 2-methoxyethylacrylate (MEA) was grafted from polysulfone (PSF) membrane via Michael addition reaction. The (1)H-nuclear magnetic resonance ((1)H NMR) and X-ray photoelectron spectroscopy (XPS) characterizations of the modified membrane showed that MEA had been successfully grafted onto PSF membrane surface. The water contact angle of the membrane surface was tested. The results showed that the water contact angle changed from 76° to 59.5°, it means that the hydrophilicity of the modified membrane was improved...
July 29, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28761529/severity-of-anemia-and-hemostatic-parameters-are-strong-predictors-of-outcome-in-postoperative-neurosurgical-patients
#10
Mrinalini Kotru, Satya Shiv Munjal, Deepti Mutreja, Guresh Kumar, Manmohan Singh, Tullika Seth, Hara Prasad Pati
OBJECTIVE: Post-operative neurosurgical patients are commonly associated with haemostatic derangements; many a times leading to development of overt disseminated intravascular coagulation (DIC) and eventually death in some of them. The present study has analysed the factors that would predict the outcome in post operative neurosurgical patients with deranged haemostatic parameters. METHODS: This is a prospective, descriptive study over a period of 15 months on 115 post operative neurosurgical patients who were clinically suspected to have DIC and investigated for the haemostatic parameters...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28747575/d-dimer-levels-are-correlated-with-disease-activity-in-crohn-s-patients
#11
Junwu Zhang, Zhen Guo, Wei Yang, Zhongliang Zhu, Wanzhong Kong, Sujie Zheng, Lei Jiang, Xianming Fei, Yanxia Chen, Jinlin Liu
Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28740434/a-global-quantitative-survey-of-hemostatic-assessment-in-postpartum-hemorrhage-and-experience-with-associated-bleeding-disorders
#12
Andra H James, David L Cooper, Michael J Paidas
PURPOSE: Coagulopathy may be a serious complicating or contributing factor to postpartum hemorrhage (PPH), and should be promptly recognized to ensure proper bleeding management. This study aims to evaluate the approaches of obstetrician-gynecologists worldwide towards assessing massive PPH caused by underlying bleeding disorders. METHODS: A quantitative survey was completed by 302 obstetrician-gynecologists from 6 countries (the UK, France, Germany, Italy, Spain, and Japan)...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28734664/ph-responsive-biodegradable-nanogels-for-sustained-release-of-bleomycin
#13
Prashant Sahu, Sushil K Kashaw, Varun Kushwah, Samaresh Sau, Sanyog Jain, Arun K Iyer
Site specific drug delivery with desired therapeutic effect still remains challenging task due to suboptimal release, tissue toxicity, low selectivity and meager therapeutic efficacy in skin cancers. The aim of the current study was to fabricate pH responsive, self-assembled, chemically cross-linked biodegradable chitosan nanogel loaded with bleomycin to target the dermal area of the skin. The nanogel synthesized by ion gelation technique and was characterized for drug loading, swelling and thermal stability followed by in vitro analysis...
June 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28730779/a-comparative-study-on-postoperative-mortality-prediction-of-sfli-scoring-system-and-child-pugh-classification-in-patients-with-hepatocellular-carcinoma
#14
Jun Zheng, Rong-Chun Xing, Wei-Hong Zheng, Wei Liu, Ru-Cheng Yao, Xiao-Song Li, Jian-Ping Du, Lin Li
PURPOSE: In our previous study, we have established the clinical significance of the SFLI (scoring formula of liver injury), the purpose of this study was to compare the SFLI system and the Child-Pugh grading system in the prediction of postoperative mortality in patients with hepatocellular carcinoma (HCC). METHODS: 114 patients with HCC who underwent surgical treatment were enrolled. According to the requirement of the indicators for the Child-Pugh classification, various indices (including albumin [ALB], total bilirubin [TBIL], prothrombin time [PT], ascites, and hepatic encephalopathy) were considered in these patients before surgery, and then Child-Pugh grading was performed...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28717372/comparison-of-platelet-number-and-function-between-nonalcoholic-fatty-liver-disease-and-normal-individuals
#15
Zeinab Saremi, Mahboobe Rastgoo, Mahyar Mohammadifard, Bita Bijari, Ehsan Akbari
BACKGROUND: There is interest about the role of platelet (PLT) number and function in nonalcoholic fatty liver disease (NAFLD). NAFLD patients have abnormalities of PLT number and function, especially mean platelet volume (MPV) which is known as a novel biomarker for atherosclerosis. We decided to compare PLT number and function between NAFLD and healthy participants. MATERIALS AND METHODS: In this case-control study, two groups of patients (65 cases with NAFLD and 65 cases without NAFLD) were included consecutively...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28698348/determinants-of-mortality-and-prolonged-hospital-stay-among-dengue-patients-attending-tertiary-care-hospital-a-cross-sectional-retrospective-analysis
#16
Tauqeer Hussain Mallhi, Amer Hayat Khan, Azmi Sarriff, Azreen Syazril Adnan, Yusra Habib Khan
OBJECTIVES: Dengue imposes substantial economic, societal and personal burden in terms of hospital stay, morbidity and mortality. Early identification of dengue cases with high propensity of increased hospital stay and death could be of value in isolating patients in need of early interventions. The current study was aimed to determine the significant factors associated with dengue-related prolonged hospitalisation and death. DESIGN: Cross-sectional retrospective study...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28681428/routine-coagulation-tests-on-icu-admission-are-associated-with-mortality-in-sepsis-an-observational-study
#17
S Benediktsson, A Frigyesi, T Kander
BACKGROUND: Low platelet count on admission to an intensive care unit (ICU) is associated with increased mortality and is thus included in some severity scoring systems such as the simplified acute physiologic score 3 (SAPS 3); however it is unclear whether other routine coagulation tests also predict mortality. The purpose of this retrospective single-centre study was to investigate whether activated partial thromboplastin time (APTT) or prothrombin time - international normalized ratio (PT-INR) measured on admission to the ICU in patients with severe sepsis or septic shock may be associated with mortality independent of SAPS 3 score...
August 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28678733/preparation-characterization-and-blood-compatibility-assessment-of-a-novel-electrospun-nanocomposite-comprising-polyurethane-and-ayurvedic-indhulekha-oil-for-tissue-engineering-applications
#18
Manikandan Ayyar, Mohan Prasath Mani, Saravana Kumar Jaganathan, Rajasekar Rathanasamy
Electrospun polyurethane based nanocomposite scaffolds were fabricated by mixing with indhulekha oil. Scanning electron microscope (SEM) portrayed the nanofibrous nature of the composite and the average diameters of the composite scaffold were smaller than the pristine scaffolds. The fabricated scaffold was found to be hydrophobic (114°) due to the inclusion of indhulekha oil, which was displayed in contact angle measurement analysis. The fourier transform infrared spectroscopy (FTIR) results indicated that the indhulekha oil was dispersed in PU matrix identified by formation of hydrogen bond and peak shifting of CH group...
July 5, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28671072/anticoagulant-activity-of-oral-rivaroxaban-in-healthy-dogs
#19
B Conversy, M C Blais, M Dunn, C Gara-Boivin, J R E Del Castillo
Rivaroxaban is an oral, direct factor Xa inhibitor used in human thrombotic disorders. In view of the in vitro concentration dependent anticoagulant effects of rivaroxaban in dogs, the time course of its anticoagulant effects was characterized in healthy dogs. Twenty-four healthy Beagles were randomized into three groups (n = 8 per group) and received orally either a placebo or 20 mg rivaroxaban once or twice at an 8 h interval. Fifteen blood samples were collected over a 30 h period, and blindly assayed for prothrombin time (PT), activated partial thromboplastin time (aPTT), tissue factor induced thrombin generation (TG) and anti-factor Xa activity...
May 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28660462/fabrication-and-characterization-of-chitosan-nanoparticles-and-collagen-loaded-polyurethane-nanocomposite-membrane-coated-with-heparin-for-atrial-septal-defect-asd-closure
#20
Eva Kaiser, Saravana Kumar Jaganathan, Eko Supriyanto, Manikandan Ayyar
Atrial septal defect (ASD) constitutes 30-40% of all congenital heart diseases in adults. The most common complications in the treatment of ASD are embolization of the device and thrombosis formation. In this research, an occluding patch was developed for ASD treatment using a well-known textile technology called electrospinning. For the first time, a cardiovascular occluding patch was fabricated using medical grade polyurethane (PU) loaded with bioactive agents namely chitosan nanoparticles (Cn) and collagen (Co) which is then coated with heparin (Hp)...
July 2017: 3 Biotech
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