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https://www.readbyqxmd.com/read/28629055/a-novel-kind-of-polysulfone-material-with-excellent-biocompatibility-modified-by-the-sulfonated-hydroxypropyl-chitosan
#1
Tian-Ming Liu, Jing-Jie Xu, Yun-Ren Qiu
In order to ameliorate the biocompatibility of polysulfone (PSf), sulfonated hydroxypropyl chitosan (SHPCS) was grafted from PSf membrane material by Schiff-Base reaction. The original and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), water contact angle (WCA) measurement, tensile strength test and antibacterial test in vitro, and the results indicated that the PSf modified by SHPCS (PSf-SHPCS) was synthesized successfully, the hydrophilicity of PSf-SHPCS membrane was improved to a great extent, all the membranes possessed good stability in physiological condition and the PSf-SHPCS membrane had good antibacterial property...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28617530/effects-of-folic-acid-combined-with-vitamin-b12-on-dvt-in-patients-with-homocysteine-cerebral-infarction
#2
X-J Shu, Z-F Li, Y-W Chang, S-Y Liu, W-H Wang
OBJECTIVE: To investigate the effects of folic acid combined with vitamin B12 on deep vein thrombosis (DVT) in patients with homocysteine cerebral infarction. PATIENTS AND METHODS: 90 patients with homocysteine cerebral infarction with DVT that were admitted to our hospital from January to July 2015 were selected as study subjects. They were divided into 2 groups randomly, the treatment group (n=45) and the non-treatment group (n=45). The treatment group was administered folic acid and vitamin B12, while the non-treatment group wasn't administered folic acid and vitamin B12...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28605659/trimester-specific-coagulation-and-anticoagulation-reference-intervals-for-healthy-pregnancy
#3
Chanjuan Cui, Shuo Yang, Jie Zhang, Guojing Wang, Shengkai Huang, Aiwei Li, Yuncong Zhang, Rui Qiao
BACKGROUND: Due to the normal physiological need of pregnancy and childbirth, the haemostatic system of pregnant women is different from that of healthy non-pregnant women. The aim of this study was to establish trimester-specific reference intervals of coagulation screening tests and thrombophilia markers in pregnancies without complications of females with Han ethnicity from North China. METHODS: In total 744 Han healthy pregnant women (first trimester 207 cases, second trimester 222 cases and third trimester 315 cases) and 121 healthy non-pregnant women were recruited in North China...
May 24, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28599468/clinical-significance-of-coagulation-factors-in-operable-colorectal-cancer
#4
Suee Lee, Seok Jae Huh, Sung Yong Oh, Myeong Seok Koh, Sung-Hyun Kim, Ji Hyun Lee, Jin Young Han, Hong Jo Choi, Su Jin Kim, Hyo-Jin Kim
Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598242/antithrombotic-effect-of-fermented-ophiopogon-japonicus-in-thrombosis-induced-rat-models
#5
Yi-Lin Zhang, Mei-Zhu Xi, Young-Bin Choi, Bog-Hieu Lee
In this study, the antithrombotic and thrombolytic ability of second fermented extract of Ophiopogon japonicus (FEOJ) was verified in thrombosis-induced rats. Thrombosis was induced by oral administration of 2% carrageenan for 4 weeks. Five experimental groups (n = 9/group) involved in the study were control group, thrombosis group, low-dose FEOJ group (2 mL/kg, low-dose Ophiopogon japonicus [LOJ]), middle-dose FEOJ group (6 mL/kg, medium-dose Ophiopogon japonicus [MOJ]), and high-dose FEOJ group (12 mL/kg, high-dose Ophiopogon japonicus [HOJ])...
June 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28593923/the-effects-of-transport-by-a-car-on-coagulation-tests
#6
Merve Ergin, Serpil Erdogan, Onur Akturk, Ozcan Erel
BACKGROUND: This research investigated the effects of the transport of blood samples between centers/laboratories by car on coagulation tests. METHODS: Five tubes of blood samples were taken from 20 healthy volunteers. The samples consisted of a baseline (control) group, centrifuged and noncentrifuged transported samples; centrifuged and noncentrifuged untransported samples. The groups of centrifuged and noncentrifuged samples were transported by car for 2 h. The centrifuged and noncentrifuged untransported samples were incubated in the laboratory until the transported samples arrived...
May 5, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28591967/-effects-of-blood-glucose-levels-on-liver-functions-in-sepsis-patients
#7
Zhi-Yun Tang, Yan Kang
OBJECTIVES: To explore the effects of blood glucose levels on liver functions in patients with sepsis treated in intensive care unit (ICU). METHODS: We performed a retrospective study on 93 patients with sepsis between March 2014 to January 2015. Patients were divided into two groups according to the initial blood glucose levels when admitted to ICU: high glucose group (blood glucose>10 mmol/L) and normal glucose group(blood glucose≤10 mmol/L). Routine blood test results, liver functions and coagulations function were compared between the two groups...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28583609/global-hemostasis-in-healthy-bitches-during-pregnancy-and-at-different-estrous-cycle-stages-evaluation-of-routine-hemostatic-tests-and-thromboelastometry
#8
Sigal Klainbart, Alexandra Slon, Efrat Kelmer, Tali Bdolah-Abram, Tal Raz, Gilad Segev, Itamar Aroch, Smadar Tal
This study assessed the global hemostasis (including prothrombin time [PT], activated partial thromboplastin time [aPTT], antithrombin activity [ATA], fibrinogen and d-Dimer concentrations, platelet count, plateletcrit and thromboelastometry) in healthy pregnant bitches, comparing the results with those of healthy bitches at different estrous cycle stages, and assessed whether hemostatic changes during pregnancy are associated with serum progesterone concentration or the presence of fetuses in utero. The results show that pregnant bitches have higher fibrinogen concentration, platelet count and platelatecrit, and that fibrin and global clot formations occur faster than in non-pregnant bitches at different estrous cycle stages...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28574019/k-time-maximum-amplitude-of-thromboelastogram-predict-post-central-venous-cannulation-bleeding-in-patients-with-cirrhosis-a-pilot-study
#9
Chandra K Pandey, Vandana Saluja, Kumar Gaurav, Manish Tandon, Vijay K Pandey, Ajeet S Bhadoria
BACKGROUND & OBJECTIVES: Coagulation and haemostasis are dynamic processes. The haemostatic changes in liver disease affect all aspects of coagulation. The prothrombin time (PT)/ international normalized ratio (INR) was developed to monitor oral anticoagulant therapy and the activated partial thromboplastin time to investigate inheritable single factor deficiencies. Viscoelastic tests such as thromboelastogram (TEG) give information about dynamics of clot formation (coagulation factor and anticoagulant activity), clot strength (platelets and fibrinogen) and clot stability (finbrinolysis and factor XIII)...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28561744/synthesis-and-thrombin-factor-xa-and-u46619-inhibitory-effects-of-non-amidino-and-amidino-n%C3%A2-thiophenecarbonyl-and-n%C3%A2-tosylanthranilamides
#10
Soo Hyun Lee, Wonhwa Lee, ThiHa Nguyen, Il Soo Um, Jong-Sup Bae, Eunsook Ma
Thrombin (factor IIa) and factor Xa (FXa) are key enzymes at the junction of the intrinsic and extrinsic coagulation pathways and are the most attractive pharmacological targets for the development of novel anticoagulants. Twenty non-amidino N²-thiophencarbonyl- and N²-tosyl anthranilamides 1-20 and six amidino N²-thiophencarbonyl- and N²-tosylanthranilamides 21-26 were synthesized to evaluate their activated partial thromboplastin time (aPTT) and prothrombin time (PT) using human plasma at a concentration of 30 µg/mL in vitro...
May 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28539856/natural-regulatory-anticoagulants-proteins-among-sudanese-patients-with-dengue-virus-infection
#11
Bashir Abdrhman Bashir, Osman Khalaf Allah Saeed
THE COAGULATION SYSTEM: Abnormalities in natural physiologic anticoagulants are observed in dengue infection. Laboratory values such as protein C (PC), protein S (PS), and antithrombin (AT) indicate this problem on the coagulation system in dengue. Recently, an interrelationship between dengue and the levels of natural anticoagulants has been observed. OBJECTIVE: The study conducted to find out the effect of dengue on the natural anticoagulant proteins. METHODS: A case-control study was conducted in Port Sudan Teaching Hospital from February 2013 to June 2014 for 334 cases of dengue caused by dengue virus, 217 (65%) males and 117 (35%) were females along with 101 cases of control 64 (63...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28537667/mechanism-of-the-high-coagulation-state-of-breast-cancer-tissue-factor
#12
X-K Mi, Q-R Liu, L Zhu, M-X Sang, L-R Guo, B-E Shan
OBJECTIVE: We conducted this study to analyze the mechanism behind the high coagulation state induced by circulating plasma microparticle tissue factor (MP-TF) in patients with breast cancer. PATIENTS AND METHODS: 87 cases of breast cancer patients (10 cases of TNM stage I, 16 cases of II, 32 cases of III, 29 cases of IV; 8 cases of pathological type in situ carcinoma, 15 cases of ductal carcinoma, 64 cases of invasive cancer) were used as the observation group and 20 cases of benign breast lesions were used as the control group to compare MP-TF levels of plasma and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer body (D-D) level and NF-κB signaling pathway index including P50, p65, TAK1 and IκBα levels...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28534370/research-on-the-coagulation-function-changes-in-non-small-cell-lung-cancer-patients-and-analysis-of-their-correlation-with-metastasis-and-survival
#13
Yongjun Qi, Jingwei Fu
PURPOSE: To investigate the relationship between coagulation function and prognosis of non-small cell lung cancer (NSCLC) patients. METHODS: 539 patients who were admitted to our hospital for the first time from December 2008 to December 2013 and pathologically diagnosed as NSCLC were enrolled in this study (study group), while 80 healthy persons served as controls (control group). Morning fasting venous blood samples were collected for coagulation function indexes, such as prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (Fib), D-dimer (D-D) and platelet count (PLT) and the coagulation function and survival rate were compared...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28527185/surface-heparinization-and-blood-compatibility-modification-of-small-intestinal-submucosa-sis-for-small-caliber-vascular-regeneration
#14
Bensong Han, Feng Xue, Cunyi Fan, Xiumei Mo
OBJECTIVES: This study aims to investigate the small intestinal submucosal (SIS) surface after heparinization with the hypothermia plasma technique, to improve the blood compatibility of SIS, and to explore the possibility of construction of small-caliber vascular grafts with modified SIS scaffolds in vivo. METHODS: SIS films prepared from jejunums of pigs were processed for surface treatment at different time periods with the argon plasma initiation technique under vacuum, and were then immediately immersed in 4% (m/v) heparin sodium solution for 24-h heparinization...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28504829/prediction-of-thrombophilia-in-patients-with-unexplained-recurrent-pregnancy-loss-using-a-statistical-model
#15
Tongfei Wang, Xiaomin Kang, Liying He, Zhilan Liu, Haijing Xu, Aimin Zhao
OBJECTIVE: To establish a statistical model to predict thrombophilia in patients with unexplained recurrent pregnancy loss (URPL). METHODS: A retrospective case-control study was conducted at Ren Ji Hospital, Shanghai, China, from March 2014 to October 2016. The levels of D-dimer (DD), fibrinogen degradation products (FDP), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (Fg), and platelet aggregation in response to arachidonic acid (AA) and adenosine diphosphate (ADP) were collected...
May 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28498944/assessment-of-standard-laboratory-tests-and-rotational-thromboelastometry-for-the-prediction-of-postoperative-bleeding-in-liver-transplantation
#16
T M Dötsch, D Dirkmann, D Bezinover, M Hartmann, J W Treckmann, A Paul, F H Saner
Background.: Perioperative bleeding remains a major challenge in liver transplantation. We aimed to compare standard laboratory tests with thromboelastometry (ROTEM ® ) with regard to their ability to predict postoperative non-surgical bleeding. Methods.: Data from 243 adult liver transplant recipients from January 2012 to May 2014 were evaluated retrospectively. Upon admission to the intensive care unit, coagulation status was assessed using standard laboratory tests [prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen concentration, and platelet count] and ROTEM ® whole blood coagulation assays...
May 12, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28488785/is-it-acceptable-to-use-coagulation-plasma-samples-stored-at-room-temperature-and-4%C3%A2-c-for-24%C3%A2-hours-for-additional-prothrombin-time-activated-partial-thromboplastin-time-fibrinogen-antithrombin-and-d-dimer-testing
#17
V Rimac, D Coen Herk
INTRODUCTION: Coagulation laboratories are faced on daily basis with requests for additional testing in already analyzed fresh plasma samples. This prompted us to examine whether plasma samples stored at room temperature (RT), and 4°C for 24 hours can be accepted for additional prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen (Fbg), antithrombin (AT), and D-dimer testing. METHODS: We measured PT, aPTT, Fbg in 50 and AT in 30 plasma samples with normal and pathological values, within 4 hours of blood collection (baseline results) and after 24-hours storage at RT (primary tubes), and 4°C (aliquots)...
May 10, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28485425/antithrombotic-effect-and-mechanism-of-rubus-spp-blackberry
#18
Pingyao Xie, Yong Zhang, Xuebiao Wang, Jinfeng Wei, Wenyi Kang
The compounds of Rubus spp. Blackberry (RSB) were isolated and identified by a bioassay-guided method, and their antithrombotic effects and mechanism were investigated with the acute blood stasis rat model. The RSB extract was evaluated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) assays in vitro. Results indicated that RSB extract exhibited anticoagulant activity. In addition to compounds 1 and 6, the other compounds also exhibited anticoagulant activity in vitro...
May 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28482536/influences-of-mesoporous-zinc-calcium-silicate-on-water-absorption-degradability-antibacterial-efficacy-hemostatic-performances-and-cell-viability-to-microporous-starch-based-hemostat
#19
Yu Hou, Yan Xia, Yongkang Pan, Songchao Tang, Xiaofei Sun, Yang Xie, Han Guo, Jie Wei
Efficacious hemostatic agents have significant potential application in visceral organ or large vessel arterial injure. In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content. Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481034/impact-of-different-storage-times-at-room-temperature-of-unspun-citrated-blood-samples-on-routine-coagulation-tests-results-results-of-a-bicenter-study-and-review-of-the-literature
#20
P Toulon, S Metge, M Hangard, S Zwahlen, S Piaulenne, V Besson
INTRODUCTION: A maximum delay between blood collection and coagulation testing of 4 hours is recommended by most guidelines. As information on optimal storage times is limited, we investigated the potential effect of different storage times of unspun tubes, that is, ≤2, 4, 6, and 8 hours, on routine coagulation test results. METHODS: Four evacuated polymer tubes containing 0.109 mol/L tri-Na citrate were drawn from 144 patients, including 39 patients on vitamin K-antagonists...
May 8, 2017: International Journal of Laboratory Hematology
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