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https://www.readbyqxmd.com/read/29149042/comparative-study-of-biological-activities-of-venom-from-colubrid-snakes-rhabdophis-tigrinus-yamakagashi-and-rhabdophis-lateralis
#1
Yumiko Komori, Toru Hifumi, Akihiko Yamamoto, Atsushi Sakai, Manabu Ato, Kyoko Sawabe, Toshiaki Nikai
Rhabdophis lateralis, a colubrid snake distributed throughout the continent of Asia, has recently undergone taxonomic revisions. Previously, Rhabdophis lateralis was classified as a subspecies of R. tigrinus (Yamakagashi) until 2012, when several genetic differences were discovered which classified this snake as its own species. To elucidate the toxicity of venom from this poorly studied colubrid, various biological activities were compared between the venom from the two snake species. The components of their venom were compared by the elution profiles of reversed-phase HPLC and SDS-PAGE, and gel filtrated fractions were tested for effects on blood coagulation...
November 17, 2017: Toxins
https://www.readbyqxmd.com/read/29145778/an-apparent-case-of-brodifacoum-toxicosis-in-a-whelping-dog
#2
Scott D Fitzgerald, Jennifer Martinez, John P Buchweitz
A 7-y-old Weimaraner bitch was presented to emergency service after 3 h of active labor with no puppies produced. Hemoabdomen and hemothorax were present at the time of surgery; prothrombin time (PT) and activated partial thromboplastin time (aPTT) were both found to be within normal ranges. Surgical cesarean section was performed; 4 dead puppies and 5 live puppies were delivered. Because hemostasis was difficult to achieve, a hysterectomy was performed; however, the dog died as the operation was being completed...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29139273/-comparative-study-on-promoting-blood-effects-of-danshen-honghua-herb-pair-with-different-preparations-based-on-chemometrics-and-multi-attribute-comprehensive-index-methods
#3
Cheng Qu, Yu-Ping Tang, Xu-Qin Shi, Gui-Sheng Zhou, Er-Xin Shang, Li-Li Shang, Jian-Ming Guo, Pei Liu, Jing Zhao, Bu-Chang Zhao, Jin-Ao Duan
To evaluate the promoting blood circulation and removing blood stasis effects of Danshen-Honghua(DH) herb pair with different preparations (alcohol, 50% alcohol and water) on blood rheology and coagulation functions in acute blood stasis rats, and optimize the best preparation method of DH based on principal component analysis(PCA), hierarchical cluster heatmap analysis and multi-attribute comprehensive index methods. Ice water bath and subcutaneous injection of adrenaline were both used to establish the acute blood stasis rat model...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29137047/massive-neonatal-intracranial-hemorrhage-caused-by-bromadiolone-a-case-report
#4
Mingsheng Ma, Mengqi Zhang, Xiaoyan Tang, Zhenghong Li
RATIONALE: Bromadiolone, often called a super-warfarin, is a potent rodenticide with long half-life. Skin and mucosal bleeding is the most common clinical manifestations of its intoxication. Bromadiolone intoxications in adults and children have been reported, but this phenomenon is rarely seen in fetuses. This paper presents a case of neonate with massive intracranial hemorrhage mediated by bromadiolone intoxication, highlighting that the bromadiolone is potentially lethal to the fetus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136561/calibrated-automated-thrombogram-values-in-infants-with-cardiac-surgery-before-and-after-cardiopulmonary-bypass
#5
Alessandra Rizza, Giovina Di Felice, Rosa Luciano, Ottavia Porzio, Ombretta Panizzon, Maurizio Muraca, Paola Cogo
INTRODUCTION: Impaired thrombin generation has been associated to increase bleeding after cardiac surgery with cardiopulmonary bypass (CPB), especially in children. The aim of this study was to evaluate standard coagulation assay, thrombin generation by calibrated automated thrombogram (CAT), thromboelastography (TEG) and procoagulant phospholipids (PPL) activity in infants undergoing cardiac surgery with CPB. MATERIALS AND METHODS: Prospective observational study performed in children aged <24months undergoing cardiac surgery with CPB...
September 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29126301/coagulation-testing-in-the-core-laboratory
#6
William E Winter, Sherri D Flax, Neil S Harris
Primary hemostasis begins with endothelial injury. VWF, produced by endothelial cells, binds to platelets and links them to subendothelial collagen. Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation. Secondary hemostasis is initiated with the binding of factor VII to extravascular tissue factor (TF). Factors II, VII, IX and X are vitamin K-dependent factors. The role of vitamin K is to assist in the addition of gamma carboxylate groups to glutamic acids in the "GLA" domains of these factors...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29109796/investigating-the-effect-of-chemical-structure-of-semiconducting-polymer-nanoparticle-on-photothermal-therapy-and-photoacoustic-imaging
#7
Dongdong Li, Guobing Zhang, Weiguo Xu, Junxia Wang, Yucai Wang, Longzhen Qiu, Jianxun Ding, Xianzhu Yang
The donor-acceptor semiconducting polymers (SPs) have robust absorbance in near-infrared (NIR) region, great photostability, high photothermal conversion efficiency, and good biocompatibility. Thus, the SPs exhibit great potentials for photothermal therapy (PTT) and photoacoustic imaging (PAI). However, poor understanding of the underlying mechanisms and the correlation between the SP polymer chemical structures and their performances of PTT and PAI have significantly hindered their biomedical application. Herein, a series of acceptor-π-acceptor type (A1-π-A2) type SPs were synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29102986/association-between-coagulation-function-and-patients-with-primary-angle-closure-glaucoma-a-5-year-retrospective-case-control-study
#8
Shengjie Li, Yanting Gao, Mingxi Shao, Binghua Tang, Wenjun Cao, Xinghuai Sun
OBJECTIVE: To evaluate the association between coagulation function and patients with primary angle closure glaucoma (PACG). DESIGN: A retrospective, hospital-based, case-control study. SETTING: Shanghai, China. PARTICIPANTS: A total of 1778 subjects were recruited from the Eye & ENT Hospital of Fudan University from January 2010 to December 2015, including patients with PACG (male=296; female=569) and control subjects (male=290; female=623)...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29091109/surface-thermal-and-hemocompatible-properties-of-novel-single-stage-electrospun-nanocomposites-comprising-polyurethane-blended-with-bio-oiltm
#9
Manikandan Ayyar, Mohan Prasath Mani, Saravana Kumar Jaganathan, Rajasekar Rathinasamy, Ahmad Zahran Khudzari, Navaneetha Pandiyaraj Krishnasamy
In this work, the physicochemical and blood compatibility properties of prepared PU/Bio oil nanocomposites were investigated. Scanning electron microscope (SEM) studies revealed the reduction of mean fiber diameter (709 ± 211 nm) compared to the pristine PU (969 nm ± 217 nm). Fourier transform infrared spectroscopy (FTIR) analysis exposed the characteristic peaks of pristine PU. Composite peak intensities were decreased insinuating the interaction of the bio oilTM with the PU. Contact angle analysis portrayed the hydrophobic nature of the fabricated patch compared to pristine PU...
October 26, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29079209/2-methoxyethylacrylate-modified-polyurethane-membrane-and-its-blood-compatibility
#10
REVIEW
Xin Tian, Yun-Ren Qiu
Hydrophilic material 2-methoxyethylacrylate (MEA) was grafted onto polyurethane (PU) membrane via Michael addition reaction. Fourier transform infrared spectroscope (FTIR) and X-ray photoelectron spectroscopy (XPS) characterizations of the modified membrane proved that MEA had been successfully grafted onto PU membrane surface. The water contact angle of membrane materials was tested. The results showed that the water contact angle changed from 86° to 48°, which means that the hydrophilicity of the modified membrane was greatly improved...
October 24, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29077118/cis-platinum-pro-drug-attached-cufes2-nanoplates-for-in-vivo-photothermal-photoacoustic-imaging-and-chemotherapy-photothermal-therapy-of-cancer
#11
Binbin Ding, Chang Yu, Chunxia Li, Xiaoran Deng, Jianxun Ding, Ziyong Cheng, Bengang Xing, Ping'an Ma, Jun Lin
Photothermal therapy (PTT) has attracted considerable attention in cancer treatment. Herein, the facile synthesis of copper iron sulfide (chalcopyrite, CuFeS2) nanoplates (NPs) with well-defined shape was achieved by a template-mediated method. Chitosan (CS), a linear cationic polysaccharide, was used to improve the physiological stability and biocompatibility. CuFeS2 NPs with strong near-infrared (NIR) absorbance enabled contrasts in photothermal and photoacoustic (PA) imaging. In vitro and in vivo tumor ablation studies further demonstrated that CS-functionalized CuFeS2 (CuFeS2-CS) NPs could convert 808 nm NIR light into heat for PTT with a photothermal conversion efficiency up to 30...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29075072/evaluation-of-coagulation-profile-in-children-with-type-1-diabetes-mellitus-using-rotational-thromboelastometry
#12
Cigdem Binay, Ayse Bozkurt Turhan, Enver Simsek, Ozcan Bor, Olga Meltem Akay
The prothrombotic state in type 1 diabetes mellitus (T1DM) has been reported as a plausible cause of vascular complications. Rotational thromboelastometry (ROTEM) assay enables the global assessment of coagulation status. This study aimed to assess hypercoagulability in children with T1DM using ROTEM. A total of 43 T1DM children (20 females and 23 males) aged 2-18 years and age- and sex-matched 30 healthy control subjects were enrolled in the study group. ROTEM assays [intrinsic TEM (INTEM) and extrinsic TEM (EXTEM)] were used to measure and analyze coagulation time (CT), clot formation time, maximum clot firmness (MCF)...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29072238/prevalence-of-lupus-anticoagulant-in-women-with-spontaneous-abortion-in-zaria
#13
I N Ibrahim, A I Mamman, S E Adaji, A Hassan, A A Babadoko
INTRODUCTION: Spontaneous abortion (SA) is a common complication of pregnancy. Presence of lupus anticoagulant (LA), one of the antiphospholipid antibodies, has been associated with SA in many studies, especially in Caucasians. This study was carried out to determine the prevalence of LA in women with SA in ABUTH, Zaria. MATERIALS AND METHODS: A cohort of 100 consecutive women presenting with SA with no history of thrombotic episodes were enrolled into the study...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29070135/-genetic-analysis-of-a-case-of-congenital-dysfibrinogenemia-caused-by-arg16his-mutation-in-exon-2-of-fga
#14
Yong-Lu Zhang, Shu-Yuan Liu, Zhang-Lin Zhang, Xiao-Yan Tao, Xiao-Xiao Peng, Yun-Yuan Kong
OBJECTIVE: To analyze the phenotype and genotype of a family with congenital dysfibrinogenemia. METHODS: Assays of coagulation, including activated partial thromboplastin time(APTT), pro-thrombin time(PT)and thrombin time(TT) were carried out with Sysmex CA-7000 in the proband and his family members. The quality and quantity of fibrinogen in plasma were determined by Clauss and electrophoresis, respectively. Fibrinogen and inconstituent were analyzed by Native-PAGE...
October 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29065860/assessment-of-haemostasis-in-patients-undergoing-emergent-neurosurgery-by-rotational-elastometry-and-standard-coagulation-tests-a-prospective-observational-study
#15
Christoph Ellenberger, Najia Garofano, Gleicy Barcelos, John Diaper, Gordana Pavlovic, Marc Licker
BACKGROUND: Rotational elastometry (ROTEM) has been shown useful to monitor coagulation in trauma patients and in major elective surgery. In this study, we aimed to evaluate the utility of ROTEM to identify hemostatic disturbances and to predict the need for transfusion, compared with standard coagulation tests (SCTs) in patients undergoing emergent neurosurgery. METHODS: Over a four-year period, adult patients who met criteria for emergent neurosurgery lasting more than 90 min were included in the study...
October 24, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29065752/is-blood-transfusion-necessary-in-all-patients-with-disseminated-intravascular-coagulation-associated-postpartum-hemorrhage
#16
Hale Goksever Celik, Engin Celik, Ismail Ozdemir, Ayse Ozge Savkli, Kamuran Sanli, Husnu Gorgen
OBJECTIVE: The diagnosis of disseminated intravascular coagulation (DIC) in obstetrics is complicated owing to physiological changes, particularly during late pregnancy and the postpartum period. Therefore, a pregnancy-modified DIC score that includes only three components of the International Society on Thrombosis and Hemostasis (ISTH) DIC score has been constructed. Our aim was to determine how many blood-transfused postpartum women actually had the diagnosis of overt DIC according to the modified ISTH score and had the correct indications for blood transfusion...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29062459/comparison-of-the-effects-of-spinal-epidural-and-general-anesthesia-on-coagulation-and-fibrinolysis-in-laparoscopic-cholecystectomy-a-randomized-controlled-trial-vsj-competition-2-nd-place
#17
Suleyman Demiryas, Turgut Donmez, Vuslat Muslu Erdem, Duygu Ayfer Erdem, Engin Hatipoglu, Sina Ferahman, Oguzhan Sunamak, Lale Yoldas Zengin, Ahmet Kocakusak
INTRODUCTION: Laparoscopic cholecystectomy (LC) is usually performed under general anesthesia. Recently, laparoscopic cholecystectomy under regional anesthesia has become popular, but this creates a serious risk of thromboembolism because of pneumoperitoneum, anesthesia technique, operative positioning, and patient-specific risk factors. AIM: This randomized controlled trial compares the effects of two different anesthesia techniques in laparoscopic cholecystectomy on coagulation and fibrinolysis...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29056892/antithrombotic-mechanism-of-polysaccharides-in-blackberry-rubus-spp-seeds
#18
Jinmei Wang, Pengli Lian, Qi Yu, Jinfeng Wei, Wenyi Kang
The blackberry seed was typically removed as a byproduct and waste from blackberry fruits for juices. Developing value-added utilization of berry seeds will significantly expand the market for berry products as well as improve benefit to berry producers. However, the research on blackberry seed is limited. The objective of this paper was to research antithrombotic mechanism of polysaccharides in blackberry seeds. Polysaccharides in blackberry seeds were extracted, purified and identified by high-performance gel permeation chromatography (HPSEC), gas chromatography (GC), fourier transform infrared (FT-IR) spectrometer and nuclear magnetic resonance spectra (NMR)...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29050713/is-preoperative-fibrinogen-testing-associated-with-total-blood-loss-in-adolescent-idiopathic-scoliosis-correction
#19
Matthew J Geck, Devender Singh, Holly Gunn, John K Stokes, Eeric Truumees
STUDY DESIGN: Retrospective analysis. OBJECTIVE: This study sought to investigate the potential association between preoperative fibrinogen, bleeding, and transfusion requirements in adolescent idiopathic scoliosis (AIS) corrections. SUMMARY OF BACKGROUND DATA: Blood loss after major spinal reconstruction increases the risks and costs of surgery. Preoperative fibrinogen levels may predict intra- and postoperative blood loss. METHODS: Data were collected from clinic charts and hospital medical records of all 110 of a single surgeon's consecutive AIS patients undergoing greater than three-level deformity correction surgeries from January 2011 to December 2013...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29034090/pre-to-postoperative-coagulation-profile-of-307-patients-undergoing-oesophageal-resection-with-epidural-blockade-over-a-10-year-period-in-a-single-hospital-implications-for-the-risk-of-spinal-haematoma
#20
Owain Thomas, Emanuel Lybeck, Per Flisberg, Ulf Schött
BACKGROUND: Epidural anaesthesia and analgesia are indicated for oesophageal surgery. A rare but serious complication is spinal haematoma, which can occur on insertion, manipulation or withdrawal of catheters. Evidence and guidelines are vague regarding which tests are appropriate and how to interpret their results. We aimed to describe how routine coagulation test results change during oesophagectomy's perioperative course. METHODS: Following ethical approval, we retrospectively identified patients who had undergone oesophagectomy between 2002 and 2012...
2017: Perioperative Medicine
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