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https://www.readbyqxmd.com/read/28817109/dysfunctional-natural-killer-cells-in-the-aftermath-of-cancer-surgery
#1
REVIEW
Leonard Angka, Sarwat T Khan, Marisa K Kilgour, Rebecca Xu, Michael A Kennedy, Rebecca C Auer
The physiological changes that occur immediately following cancer surgeries initiate a chain of events that ultimately result in a short pro-, followed by a prolonged anti-, inflammatory period. Natural Killer (NK) cells are severely affected during this period in the recovering cancer patient. NK cells play a crucial role in anti-tumour immunity because of their innate ability to differentiate between malignant versus normal cells. Therefore, an opportunity arises in the aftermath of cancer surgery for residual cancer cells, including distant metastases, to gain a foothold in the absence of NK cell surveillance...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28815548/persistent-increase-in-tnf-and-il-1-markers-in-severe-mental-disorders-suggests-trait-related-inflammation-a-one-year-follow-up-study
#2
R H Mørch, I Dieset, A Faerden, S Hope, M Aas, M Nerhus, E S Gardsjord, M Haram, R S Falk, I Joa, G Morken, I Agartz, P Aukrust, S Djurovic, I Melle, T Ueland, O A Andreassen
OBJECTIVE: We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. METHODS: Soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist (IL-1Ra), von Willebrand factor (VWF), and osteoprotegerin (OPG) were measured in schizophrenia (n = 69) and affective (n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls (HC) (n = 92) with analysis of covariance...
August 16, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28815301/keeping-brains-young-with-making-music
#3
Lars Rogenmoser, Julius Kernbach, Gottfried Schlaug, Christian Gaser
Music-making is a widespread leisure and professional activity that has garnered interest over the years due to its effect on brain and cognitive development and its potential as a rehabilitative and restorative therapy of brain dysfunctions. We investigated whether music-making has a potential age-protecting effect on the brain. For this, we studied anatomical magnetic resonance images obtained from three matched groups of subjects who differed in their lifetime dose of music-making activities (i.e., professional musicians, amateur musicians, and non-musicians)...
August 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28814475/developmental-pathway-genes-and-neural-plasticity-underlying-emotional-learning-and-stress-related-disorders
#4
Marissa E Maheu, Kerry J Ressler
The manipulation of neural plasticity as a means of intervening in the onset and progression of stress-related disorders retains its appeal for many researchers, despite our limited success in translating such interventions from the laboratory to the clinic. Given the challenges of identifying individual genetic variants that confer increased risk for illnesses like depression and post-traumatic stress disorder, some have turned their attention instead to focusing on so-called "master regulators" of plasticity that may provide a means of controlling these potentially impaired processes in psychiatric illnesses...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28813497/high-hydrostatic-pressure-induces-pro-osteoarthritic-changes-in-cartilage-precursor-cells-a-transcriptome-analysis
#5
Kevin Montagne, Yasuko Onuma, Yuzuru Ito, Yasuhiko Aiki, Katsuko S Furukawa, Takashi Ushida
Due to the high water content of cartilage, hydrostatic pressure is likely one of the main physical stimuli sensed by chondrocytes. Whereas, in the physiological range (0 to around 10 MPa), hydrostatic pressure exerts mostly pro-chondrogenic effects in chondrocyte models, excessive pressures have been reported to induce detrimental effects on cartilage, such as increased apoptosis and inflammation, and decreased cartilage marker expression. Though some genes modulated by high pressure have been identified, the effects of high pressure on the global gene expression pattern have still not been investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28813296/couple-conflict-insights-from-an-attachment-perspective
#6
REVIEW
Judith A Feeney, Gery C Karantzas
The experience of conflict is often cited as a highly stressful relational phenomenon by romantic couples, and can have negative implications for relationship satisfaction and for the longevity of romantic relationships. In this paper, we review extant research on couple conflict in romantic relationships from an attachment theory perspective. The research we review is underpinned by two central tenets: firstly, severe or persistent conflict activates the attachment system; secondly, responses to couple conflict involve complex attachment dynamics, shaped by partners' attachment anxiety and avoidance...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813015/transcriptional-responses-of-creeping-bentgrass-to-2-3-butanediol-a-bacterial-volatile-compound-bvc-analogue
#7
Yi Shi, Kuiju Niu, Bingru Huang, Wenhui Liu, Huiling Ma
Bacterial volatile compounds (BVCs) have been reported to enhance plant growth and elicit plant defenses against fungal infection and insect damage. The objective of this study was to determine transcriptomic changes in response to synthetic BVC that could be associated with plant resistance to Rhizoctonia solani in creeping bentgrass. The 2,3-butanediol (BD) (250 µM) was sprayed on creeping bentgrass leaves grown in jam jars. The result showed that synthetic BD induced plant defense against R. solani for creeping bentgrass...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28811913/burnout-and-psychiatric-morbidity-among-doctors-in-the-uk-a-systematic-literature-review-of-prevalence-and-associated-factors
#8
REVIEW
Udemezue O Imo
Aims and method To systematically review the prevalence and associated factors of burnout and stress-related psychiatric disorders among UK doctors. An extensive search was conducted of PubMed, EBSCOhost and British medical journals for studies published over a 20-year span measuring the prevalence of psychiatric morbidity (using the General Health Questionnaire) and burnout (using the Maslach Burnout Inventory). Results Prevalence of psychiatric morbidity ranged from 17 to 52%. Burnout scores for emotional exhaustion ranged from 31 to 54...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811864/identification-of-four-oxidative-stress-responsive-micrornas-mir-34a-5p-mir-1915-3p-mir-638-and-mir-150-3p-in-hepatocellular-carcinoma
#9
Yong Wan, Ruixia Cui, Jingxian Gu, Xing Zhang, Xiaohong Xiang, Chang Liu, Kai Qu, Ting Lin
Increasing evidence suggests that oxidative stress plays an essential role during carcinogenesis. However, the underlying mechanism between oxidative stress and carcinogenesis remains unknown. Recently, microRNAs (miRNAs) are revealed to be involved in oxidative stress response and carcinogenesis. This study aims to identify miRNAs in hepatocellular carcinoma (HCC) cells which might involve in oxidative stress response. An integrated analysis of miRNA expression signature was performed by employing robust rank aggregation (RRA) method, and four miRNAs (miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p) were identified as the oxidative stress-responsive miRNAs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28811603/2-4-6-trinitrotoluene-induces-apoptosis-via-ros-regulated-mitochondrial-dysfunction-and-endoplasmic-reticulum-stress-in-hepg2-and-hep3b-cells
#10
Hung-Yu Liao, Chih-Ming Kao, Chao-Ling Yao, Po-Wei Chiu, Chun-Chen Yao, Ssu-Ching Chen
2,4,6-trinitrotoluene (TNT) has been reported to cause numerous adverse effects. However, the detailed molecular mechanisms underlying TNT-induced liver toxicity need to be elucidated. In this study, we used HepG2 (p53wt) and Hep3B (p53null) cell lines to investigate the cytotoxic effects of TNT. At first, we found that TNT significantly decreased cell viability and induced DNA damage. Thereafter, through transcriptomic analysis, we observed that the diverse biological functions affected included mitochondrial dysfunction and endoplasmic reticulum (ER) stress...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810987/deployment-length-inflammatory-markers-and-ambulatory-blood-pressure-in-military-couples
#11
Stephanie Brooks Holliday, Amy DeSantis, Anne Germain, Daniel J Buysse, Karen A Matthews, Wendy M Troxel
INTRODUCTION: Changes in the frequency, duration, and nature of military deployments over the past 14 years have spurred efforts to understand the effects of deployment on the health of military service members and their spouses. However, few studies have examined the impact of deployments on health outcomes in both veterans and their partners. This study aims to examine the association between deployment length and health, including ambulatory blood pressure (BP) and stress-related markers of inflammation, in military veterans and their spouses...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810969/a-review-of-the-effectiveness-of-a-combat-and-operational-stress-control-restoration-center-in-afghanistan
#12
Jason L Judkins, Devvon L Bradley
BACKGROUND: The management of Combat and Operational Stress Reactions (COSR) within an operational environment is a multidimensional process. The aim is to help prevent behavioral health problems, preserve combat power, and increase return to duty rates for combat stress related casualties. In some COSR cases, enhanced services are required and the Combat and Operational Stress Control (COSC) Clinic refers Service Members (SMs) to the Freedom Restoration Clinic (FRC). The purpose was to describe a deployed restoration center in Afghanistan and examine the long-term effectiveness of those services...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808909/oxytocin-and-anxiety-disorders-translational-and-therapeutic-aspects
#13
REVIEW
Wadih Jean Naja, Michaelangelo Pietro Aoun
PURPOSE OF REVIEW: This review aims to evaluate the most recent literature examining the oxytocin (OXT) system's role in human anxiety by surveying various fields of preclinical and clinical research supporting this role, and queries whether the OXT system might be a target for novel anxiolytics. RECENT FINDINGS: Evidence from the diverse body of literature presented here, from translational research, genetic and neuroimaging studies, to clinical trials of intranasal (IN) OXT reveals a positive association...
August 15, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28806956/mirnas-regulate-oxidative-stress-related-genes-via-binding-to-the-3-utr-and-tata-box-regions-a-new-hypothesis-for-cataract-pathogenesis
#14
Changrui Wu, Zhao Liu, Le Ma, Cheng Pei, Li Qin, Ning Gao, Jun Li, Yue Yin
BACKGROUND: Age-related cataracts are related to oxidative stress. However, the genome-wide screening of cataract related oxidative stress related genes are not thoroughly investigated. Our study aims to identify cataract regulated miRNA target genes that are related to oxidative stress and to propose a new possible mechanism for cataract formation. METHODS: Microarrays were used to determine the mRNA expression profiles of both transparent and cataractous lenses...
August 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28806609/sleep-disturbances-in-young-and-middle-aged-adults-empirical-patterns-and-related-factors-from-an-epidemiological-survey
#15
Wulf Rössler, Vladeta AjdacicGross, Nick Glozier, Stephanie Rodgers, Helene Haker, Mario Müller
BACKGROUND: Previous research suggests that sleep disorders are highly associated with other mental health problems. However, sleep problems even below the diagnostic threshold of sleep disorders are very common in the general population, which highly affects wellbeing and functioning. In order to broaden the focus beyond those severe cases we explored empirical patterns across the whole spectrum of sleep problems as well as associated clinical and other factors. METHOD: A representative community sample of N=1274 residents from the canton of Zurich was interviewed for sleep problems and diagnostic criteria for mental disorders as well as was given a number of mental health-related psychometrical checklists...
July 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28806607/dissociation-in-patients-with-borderline-personality-disorder-in-acute-inpatient-care-a-latent-profile-analysis
#16
Susanne Jaeger, Tilman Steinert, Carmen Uhlmann, Erich Flammer, Dana Bichescu-Burian, Stefan Tschöke
PURPOSE: Dissociation is a common symptom in Borderline Personality disorder (BPD) and its consideration is important for the therapeutic outcome. The aim of this cross-sectional study was to scrutinize the co-occurrence of BPD symptoms and dissociative experiences. In particular, we were interested in the occurrence of specific symptom clusters characterizing qualitatively different patient groups in a clinical sample of BPD patients. BASIC PROCEDURES: We analyzed the data of 103 patients in a specialized acute inpatient care crisis intervention unit...
July 20, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28805696/licochalcone-a-inhibits-the-proliferation-of-human-lung-cancer-cell-lines-a549-and-h460-by-inducing-g2-m-cell-cycle-arrest-and-er-stress
#17
Chenyu Qiu, Tingting Zhang, Wenxin Zhang, Lina Zhou, Bin Yu, Wei Wang, Zhihong Yang, Zhiguo Liu, Peng Zou, Guang Liang
Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, has wide spectrum of pharmacological activities. In this study, the anti-cancer effects and potential mechanisms of LicA in non-small cell lung cancer (NSCLC) cells were studied. LicA decreased cell viability and induced apoptosis in a dose-dependent manner in NSCLC cells. LicA inhibited lung cancer cells growth by blocking cell cycle progression at the G2/M transition and inducing apoptosis. LicA treatment decreased the expression of MDM2, Cyclin B1, Cdc2 and Cdc25C in H460 and A549 cancer cell lines...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804950/non-invasive-assessment-of-adrenocortical-function-as-a-measure-of-stress-in-the-endangered-golden-langur
#18
Jatin Sarmah, Chaya R Hazarika, Elizabeth V Berkeley, Stefanie B Ganswindt, Andre Ganswindt
The golden langur (Trachypithecus geei) is an endangered primate endemic to northern India and Bhutan. The main stressors to the species are habitat degradation and fragmentation. Non-invasive fecal glucocorticoid metabolite (fGCM) analysis is a powerful tool for assessing stress associated with environmental disturbances in wildlife. However, interspecific differences in glucocorticoid metabolism require careful selection of the antibody used in their quantification. The goals of this study were to: 1) validate an enzyme immunoassay (EIA) to determine fecal GC metabolite (fGCM) concentrations in the golden langur and 2) compare fGCM concentrations between golden langurs living under different environmental conditions...
July 2017: Zoo Biology
https://www.readbyqxmd.com/read/28804535/hongjingtian-injection-attenuates-myocardial-oxidative-damage-via-promoting-autophagy-and-inhibiting-apoptosis
#19
Shujing Zhang, Ling Zhang, Han Zhang, Guanwei Fan, Jiuwen Qiu, Zongbao Fang, Haibo Wu, Yi Wang, Xiaoping Zhao
Natural products with antioxidative activities are widely applied to prevent and treat various oxidative stress related diseases, including ischemic heart disease. However, the cellular and molecular mechanisms of those therapies are still needed to be illustrated. In this study, we characterized the cardioprotective effects of Hongjingtian Injection (HJT), an extensively used botanical drug for treating coronary heart disease. The H/R-induced profound elevation of oxidative stress was suppressed by HJT. HJT also attenuates oxidative injury by promoting cell viability, intracellular ATP contents, and mitochondrial oxygen consumption...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28804508/a-psychology-of-the-human-brain-gut-microbiome-axis
#20
Andrew P Allen, Timothy G Dinan, Gerard Clarke, John F Cryan
In recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems: the brain-gut-microbiome axis. Although research has demonstrated that the gut microbiota can impact upon cognition and a variety of stress-related behaviours, including those relevant to anxiety and depression, we still do not know how this occurs. A deeper understanding of how psychological development as well as social and cultural factors impact upon the brain-gut-microbiome axis will contextualise the role of the axis in humans and inform psychological interventions that improve health within the brain-gut-microbiome axis...
April 2017: Social and Personality Psychology Compass
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