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https://www.readbyqxmd.com/read/29245042/is-the-diagnostic-threshold-for-bulimia-nervosa-clinically-meaningful
#1
Danielle A N Chapa, Brittany K Bohrer, Kelsie T Forbush
The DSM-5 differentiates full- and sub-threshold bulimia nervosa (BN) according to average weekly frequencies of binge eating and inappropriate compensatory behaviors. This study was the first to evaluate the modified frequency criterion for BN published in the DSM-5. The purpose of this study was to test whether community-recruited adults (N=125; 83.2% women) with current full-threshold (n=77) or sub-threshold BN (n=48) differed in comorbid psychopathology and eating disorder (ED) illness duration, symptom severity, and clinical impairment...
December 8, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/29244693/bilateral-simultaneous-femoral-neck-stress-fracture-despite-clinical-recovery-from-anorexia-nervosa-a-case-report
#2
Jacques Hernigou, Simon Koulischer, Renaud Maes
CASE: A 38-year-old woman who had returned to sports activity (running) after having clinically recovered from anorexia nervosa presented with a bilateral femoral neck stress fracture that was treated with bilateral hip osteosynthesis. CONCLUSION: Although exercise is usually considered to be beneficial for health, heavy exercise (such as running) after recovery from anorexia nervosa may be associated with an increased risk of fracture.
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244231/differences-in-regional-grey-matter-volumes-in-currently-ill-patients-with-anorexia-nervosa
#3
Andrea Phillipou, Susan Lee Rossell, Caroline Gurvich, David Jonathan Castle, Larry Allen Abel, Richard Grant Nibbs, Matthew Edward Hughes
Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty-six individuals with AN and 27 healthy controls underwent a T1-weighted magnetic resonance imaging (MRI) scan...
December 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29240508/medical-complications-of-bulimia-nervosa
#4
Philip S Mehler, Anne O'Melia, Carrie Brown, Dennis Gibson, Jeff Hollis, Patricia Westmoreland
Bulimia nervosa is a psychiatric disorder with many different medical sequelae. This article reviews the principal medical complications associated with bulimia nervosa, and emphasizes the importance of a timely approach to diagnosis and management.
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29239739/endophenotypes-a-conceptual-link-between-anorexia-nervosa-and-autism-spectrum-disorder
#5
Z C Zhou, D B McAdam, D R Donnelly
The paper, by translating the concept and the two models of endophenotype (EP), strengthens the hypothesis that there exists a linkage between anorexia nervosa (AN) and autism spectrum disorder (ASD). Specifically, the paper synthesizes empirical research that supported the idea that individuals with AN and individuals with ASD share similarities with respect to their neurocognitive EPs and temperament EPs. The paper then introduces an innovative structure to emphasize the subtle difference between neurocognitive EPs and temperament EPs in relation to AN and ASD...
November 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29235044/worse-survival-after-breast-cancer-in-women-with-anorexia-nervosa
#6
Annet Bens, Fotios C Papadopoulos, Eero Pukkala, Anders Ekbom, Mika Gissler, Lene Mellemkjær
PURPOSE: A history of anorexia nervosa has been associated with a reduced risk of developing breast cancer. We investigated survival after breast cancer among women with a prior anorexia nervosa diagnosis compared with women in a population comparison group. METHODS: This register-based study included combined data from Sweden, Denmark and Finland. A total of 76 and 1462 breast cancer cases identified among 22,654 women with anorexia nervosa and 224,619 women in a population comparison group, respectively, were included in the study...
December 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29231147/neuroendocrine-and-metabolic-disorders-in-bulimia-nervosa
#7
Walter Milano, Anna Capasso
BACKGROUND AND OBJECTIVE: Bulimia nervosa, is an eating disorder characterized by excessive influence of weight and body shape on the levels of self-esteem, with pervasive feelings of failure and inadequacy. The eating is characterized by the presence of episodes of uncontrolled eating (Binge), during which the person ingests mass wide variety of foods and the feeling of not being able to stop eating. This review focuses on the metabolic and hormonal alterations in the in bulimia nervosa...
December 11, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29228517/cost-effectiveness-of-internet-based-cognitive-behavioral-treatment-for-bulimia-nervosa-results-of-a-randomized-controlled-trial
#8
Hunna J Watson, Nicole McLagan, Stephanie C Zerwas, Ross D Crosby, Michele D Levine, Cristin D Runfola, Christine M Peat, Markus Moessner, Benjamin Zimmer, Sara M Hofmeier, Robert M Hamer, Marsha D Marcus, Cynthia M Bulik, Scott J Crow
OBJECTIVE: To evaluate the cost-effectiveness of Internet-based cognitive-behavioral therapy for bulimia nervosa (CBT-BN) compared to face-to-face delivery of CBT-BN. METHODS: This study is a planned secondary analysis of data from a randomized clinical trial. Participants were 179 adults (98% female, mean age = 28 years) meeting DSM-IV criteria for bulimia nervosa who were randomized to group face-to-face or group Internet-based CBT-BN for 16 sessions during 20 weeks...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29223281/human-studies-on-hypothalamo-pituitary-adrenal-hpa-axis
#9
REVIEW
Kamani Liyanarachchi, Richard Ross, Miguel Debono
The daily rhythm of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by the central clock in the suprachiasmatic nucleus. Cortisol, a glucocorticoid, acts as a secondary messenger between the central clock and the peripheral tissues. Changes in clock time, as seen in shift workers, alters the HPA axis and results in metabolic disturbances associated with ill health. Depression, anorexia nervosa and obstructive sleep apnoea, are associated with cortisol rhythm phase shifts and increased cortisol exposure...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29219202/disturbance-of-gut-satiety-peptide-in-purging-disorder
#10
Pamela K Keel, Lisa A Eckel, Britny A Hildebrandt, Alissa A Haedt-Matt, Jonathan Appelbaum, David C Jimerson
OBJECTIVE: Little is known about biological factors that contribute to purging after normal amounts of food-the central feature of purging disorder (PD). This study comes from a series of nested studies examining ingestive behaviors in bulimic syndromes and specifically evaluated the satiety peptide YY (PYY) and the hunger peptide ghrelin in women with PD (n = 25), bulimia nervosa-purging (BNp) (n = 26), and controls (n = 26). Based on distinct subjective responses to a fixed meal in PD (Keel, Wolfe, Liddle, DeYoung, & Jimerson, ), we tested whether postprandial PYY response was significantly greater and ghrelin levels significantly lower in women with PD compared to controls and women with BNp...
December 8, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29218761/naturalistic-outcome-of-family-based-inpatient-treatment-for-adolescents-with-anorexia-nervosa
#11
Inger Halvorsen, Deborah Lynn Reas, Jan-Vegard Nilsen, Øyvind Rø
BACKGROUND: Outpatient family-based treatment (FBT) is the best-documented treatment for adolescent anorexia nervosa (AN), but research is scarce on FBT adapted to inpatient settings. AIM: The naturalistic outcome of inpatient FBT for adolescent AN was investigated. METHODS: Thirty-seven (65%) of 57 patients who received inpatient FBT at a tertiary adolescent eating disorders (ED) unit participated in a follow-up interview (mean 4.5 ± 1...
December 8, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29218756/weight-suppression-but-not-symptom-improvement-predicts-weight-gain-during-inpatient-treatment-for-bulimia-nervosa
#12
Johannes Baltasar Hessler, Alice Diedrich, Martin Greetfeld, Sandra Schlegl, Caroline Schwartz, Ulrich Voderholzer
OBJECTIVE: Fear of gaining weight is a common obstacle to seeking treatment for bulimia nervosa (BN). We investigated changes in body mass index (BMI) during inpatient treatment for BN in relation to treatment outcome and weight suppression (WS). METHODS: Female inpatients of a specialized eating disorders clinic were grouped as deteriorated/unchanged, reliably improved, and clinically significantly improved based on Eating Disorder Inventory-2 scores. Repeated measures ANOVA was employed to examine changes in BMI between admission and discharge depending on treatment outcome and WS...
December 8, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29215937/orthorexia-nervosa-a-review-of-the-literature
#13
Christine B Costa, Kholoud Hardan-Khalil, Kimberly Gibbs
BACKGROUND: The phenomenon of orthorexia nervosa (ON) has been noted by clinicians since 1996 and described in the scientific literature, and yet there is no formal recognition of ON as a psychiatric diagnosis. OBJECTIVE: Review the latest available literature regarding diagnoses similarities, presentation uniqueness, assessment/assessment tools, and suggested treatments of ON. METHOD/DESIGN: A literature search of four databases focusing on articles published between 2000 and 2016 was conducted to evaluate the status of the literature on Orthorexia...
December 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29215777/atypical-anorexia-nervosa-is-not-related-to-brain-structural-changes-in-newly-diagnosed-adolescent-patients
#14
Gaia Olivo, Linda Solstrand Dahlberg, Lyle Wiemerslage, Ingemar Swenne, Christina Zhukovsky, Helena Salonen-Ros, Elna-Marie Larsson, Santino Gaudio, Samantha J Brooks, Helgi B Schiöth
OBJECTIVE: Patients with atypical anorexia nervosa (AN) have many features overlapping with AN in terms of genetic risk, age of onset, psychopathology and prognosis of outcome, although the weight loss may not be a core factor. While brain structural alterations have been reported in AN, there are currently no data regarding atypical AN patients. METHOD: We investigated brain structure through a voxel-based morphometry analysis in 22 adolescent females newly-diagnosed with atypical AN, and 38 age- and sex-matched healthy controls (HC)...
December 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29215743/driven-exercise-in-the-absence-of-binge-eating-implications-for-purging-disorder
#15
Janet A Lydecker, Megan Shea, Carlos M Grilo
OBJECTIVE: Purging disorder (PD) is characterized by recurrent purging without objectively large binge-eating episodes. PD has received relatively little attention, and questions remain about the clinical significance of "purging" by exercise that is driven or compulsive (i.e., as extreme compensatory or weight-control behavior). The little available research suggests that individuals who use exercise as a compensatory behavior might have less eating-disorder psychopathology than those who purge by vomiting or laxatives, but those studies have had smaller sample sizes, defined PD using low-frequency thresholds, and defined exercise without weight-compensatory or driven elements...
December 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29214796/grey-matter-correlates-of-autistic-traits-in-women-with-anorexia-nervosa
#16
Malin Björnsdotter, Monika Davidovic, Louise Karjalainen, Göran Starck, Håkan Olausson, Elisabet Wentz
Background: Patients with anorexia nervosa exhibit higher levels of behaviours typically associated with autism-spectrum disorder (ASD), but the neural basis is unclear. We sought to determine whether elevated autistic traits in women with anorexia nervosa may be reflected in cortical morphology. Methods: We used voxel-based morphometry (VBM) to examine regional grey matter volumes in high-resolution MRI structural brain scans in women with anorexia nervosa and matched healthy controls...
December 7, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29214022/advancing-our-understanding-of-the-neurobiology-of-anorexia-nervosa-translation-into-treatment
#17
Lasse Bang, Janet Treasure, Øyvind Rø, Andreas Joos
A wealth of studies has investigated the neurobiological underpinnings of anorexia nervosa. In our letter to the editor, we point to a number of ways in which the advances in our understanding of the neurobiology of anorexia nervosa - focusing on neuroimaging studies of brain structure and function - can be translated into treatment. We point to how such advances can: inform psychological treatment, be implemented in psychoeducation, point to novel therapeutic targets, lead to the identification of biomarkers, and expand our vocabulary for how we think and talk about anorexia nervosa...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29211319/clinical-implications-of-bone-marrow-adiposity
#18
REVIEW
Annegreet G Veldhuis-Vlug, Clifford J Rosen
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone marrow in close contact to bone cells and hematopoietic cells. Marrow adipocytes arise from the mesenchymal stem cell and share their origin with the osteoblastst. Shifts in the lineage allocation of the mesenchymal stromal cell could potentially explain the association between increased MAT and increased fracture risk in diseases such as postmenopausal osteoporosis, anorexia nervosa and diabetes. Functionally, marrow adipocytes secrete adipokines, such as adiponectin, and cytokines, such as RANK-ligand and stem cell factor...
December 6, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29210607/detection-of-anorexia-nervosa-in-primary-care
#19
Ashley Higgins, Stacey Cahn
In the years preceding diagnosis, individuals with anorexia nervosa (AN) attend more primary care appointments than their peers. Primary care physicians (PCPs) may be uniquely situated to detect AN in early manifestations. In this study, a sample of physicians was recruited online. Videotaped vignettes of a primary care appointment were shown to these participants, who were asked to diagnose the patient and could make a referral. 61.2% of participants identified an eating disorder (ED) diagnosis. However, of those, only 40% intended to refer for therapy...
December 6, 2017: Eating Disorders
https://www.readbyqxmd.com/read/29209500/examining-a-staging-model-for-anorexia-nervosa-empirical-exploration-of-a-four-stage-model-of-severity
#20
Sarah Maguire, Lois J Surgenor, Daniel Le Grange, Hubert Lacey, Ross D Crosby, Scott G Engel, Kirsty M Fromholtz, Bryony Bamford, Stephen Touyz
Background: An illness staging model for anorexia nervosa (AN) has received increasing attention, but assessing the merits of this concept is dependent on empirically examining a model in clinical samples. Building on preliminary findings regarding the reliability and validity of the Clinician Administered Staging Instrument for Anorexia Nervosa (CASIAN), the current study explores operationalising CASIAN severity scores into stages and assesses their relationship with other clinical features...
2017: Journal of Eating Disorders
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