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JOURNAL ARTICLE
Guo-Qiang Zhang, Xiao-Xuan Wu, Bao-Yin Zhao, Meng-Yue Wang, Hong-Xia Zhang, Yong-Qiang Wang
Five-carbon (C5 ) units are the fundamental building blocks that constitute a multitude of natural products. Herein we report an unprecedented unusual C5 functionalization of indole regioselectively at the C-2-position enabled by a (2-pyridyl)sulfonyl-directing palladium-catalyzed dehydrogenative strategy with a bulk chemical 2-methyl-2-butene as a C5 source. Compared to typical C5 functionalization using pentenyl alcohols, carbonates, borates, or halides as the C5 source, the protocol not only has a low cost advantage but also is of atom and step economy...
April 23, 2024: Organic Letters
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J Christoph Katthagen, Michael J Raschke, Karen Fischhuber, Janette Iking, Ursula Marschall, Julia Sussiek, Andreas Faldum, Josef Stolberg-Stolberg, Jeanette Köppe
BACKGROUND: Little is known about the frequency and results of conservative treatment of proximal humerus fractures in older individuals. METHODS: Billing data of the BARMER health insurance carrier for all patients of age 65 and above with proximal humerus fractures in the years 2005-2021 were retrospectively analyzed with multivariable Cox regression models, taking account of the patients' age, sex, and comorbidity profiles. The defined primary endpoints were overall survival (OS), major adverse events (MAE), thromboembolic events (TE), and complications of surgery or of trauma...
June 28, 2024: Deutsches Ärzteblatt International
#3
EDITORIAL
Carolin V Schneider, Kai Markus Schneider, Rohit Loomba
No abstract text is available yet for this article.
May 2024: Alimentary Pharmacology & Therapeutics
#4
JOURNAL ARTICLE
Zhang Delong, Wang Fugui, Hu Xin, Lu Houqing
Thyroid storm is a rare but well-known life-threatening complication that occurs due to acute exacerbation of thyrotoxicosis with the increased levels of circulating thyroid hormones. Reports of metabolic encephalopathy associated with thyroid storm are scarce. We describe the case of a 23-year-old male patient with no previous history of abnormal thyroid function who had consumed excessive amounts of alcohol before disease onset. The patient was found unconscious and febrile on a roadside by a passerby and was admitted to our hospital's emergency department...
April 19, 2024: Archives of Endocrinology and Metabolism
#5
JOURNAL ARTICLE
Kayla Ford, Byron L Zamboanga, Amie R Newins, Margo C Hurlocker, Michael B Madson
OBJECTIVE: Underage drinking disengagement (UDD; cognitive restructuring/minimizing agency) measures attitudes about the acceptability and responsibility of drinking. We examined demographic correlates of UDD, as well as the moderating effects of legal drinking status on the association between UDD and drinking. PARTICIPANTS: College student drinkers ( n = 893; Mage = 19.48, range = 18-25; White = 74.1%; female = 68.1%) from a multi-site study. METHODS: An online confidential survey included the UDD Scale for College Students and the AUDIT-C...
April 23, 2024: Journal of American College Health: J of ACH
#6
JOURNAL ARTICLE
Dalnim Cho, Michael Roth, Susan K Peterson, Kristofer Jennings, Seokhun Kim, Shiao-Pei Weathers, Sairah Ahmed, J Andrew Livingston, Carlos Barcenas, Y Nancy You, Kathrin Milbury
BACKGROUND: Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in their developmental transitions. Cancer treatment can also cause adverse long-term effects, chronic conditions, psychological issues, and decreased quality of life (QoL) among young adults. Despite numerous health benefits of health behaviors (eg, physical activity, healthy eating, no smoking, no alcohol use, and quality sleep), young adult cancer survivors report poor health behavior profiles...
April 23, 2024: JMIR Research Protocols
#7
JOURNAL ARTICLE
Jing Zhao, Yongquan Dong, Eva Clark, Jose M Garcia, Donna L White, Jennifer R Kramer, Angela L Mazul, Christine Hartman, Elizabeth Y Chiao
OBJECTIVES: People living with HIV (PWH) may have an increased burden of penile cancer. We aimed to evaluate the risk of penile cancer in PWH compared to that of the general population. DESIGN: We conducted a nationwide retrospective matched cohort study of penile cancer incidence among veterans living with HIV (VWH) compared to veterans without HIV. METHODS: We compared penile cancer incidence rates in 44,173 VWH to those of veterans without Human Immunodeficiency virus (HIV) (N = 159,443; 4:1 matched in age...
April 23, 2024: AIDS
#8
JOURNAL ARTICLE
Patrick A Twohig, Thoetchai Bee Peeraphatdit, Kaeli Samson, Makayla Schissel, Lynette Smith, Allison Ashford, Laura Freese, Timothy McCashland
BACKGROUND: Over 50% of hospitalizations from hepatic encephalopathy (HE) are preventable, but patients often do not receive medical treatment. AIMS: To use a multimodal education intervention (MMEI) to increase HE treatment rates and to evaluate (1) trends in HE treatment, (2) predictors of receiving treatment, and (3) the impact of treatment on hospitalization outcomes. METHODS: Prospective single-center cohort study of patients hospitalized with HE from April 1, 2020-September 30, 2022...
April 23, 2024: Digestive Diseases and Sciences
#9
JOURNAL ARTICLE
Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder.
Erica N Grodin, Dylan Kirsch, Malia Belnap, Lara A Ray
BACKGROUND: Alcohol use disorder (AUD) and stress influence overlapping neural circuits in the brain. The literature is mixed regarding the presence of sex differences in the neural response to acute stressors, and this issue has not been examined in individuals with AUD. We validated a stress functional magnetic resonance imaging (fMRI) paradigm in individuals with AUD and tested for sex differences. METHODS: Twenty-five treatment-seeking individuals with AUD (15M/10F) were recruited to participate in the neuroimaging study linked to a clinical trial of ibudilast (NCT03594435)...
April 23, 2024: Alcohol Clin Exp Res (Hoboken)
#10
JOURNAL ARTICLE
Qizhen Cui, Qingqing Liu, Yutong Fan, Chenhe Wang, Yufei Li, Shuyuan Li, Jianguo Zhang, Guodong Rao
This study identified 16 pyridoxal phosphate-dependent decarboxylases in olive at the whole-genome level, conducted analyses on their physicochemical properties, evolutionary relationships and characterized their activity. Group II pyridoxal phosphate-dependent decarboxylases (PLP_deC II) mediate the biosynthesis of characteristic olive metabolites, such as oleuropein and hydroxytyrosol. However, there have been no report on the functional differentiation of this gene family at the whole-genome level. This study conducted an exploration of the family members of PLP_deC II at the whole-genome level, identified 16 PLP_deC II genes, and analyzed their gene structure, physicochemical properties, cis-acting elements, phylogenetic evolution, and gene expression patterns...
April 23, 2024: Plant Cell Reports
#11
JOURNAL ARTICLE
Hans-Joachim Trappe
BACKGROUND: Max Reger was an organist, university teacher and composer whose life, illnesses, death and dying are not or hardly known to many. OBJECTIVES: Which illnesses determined Reger's life and did his lifestyle and illnesses influence his compositional work? Could his early death have been avoided? From today's point of view, could modern intensive care medicine have helped him? MATERIAL AND METHODS: A detailed analysis of Reger's diseases was performed using scientific databases (medline, pubmed)...
April 23, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#12
JOURNAL ARTICLE
Akash Roy, Nipun Verma, Surabhi Jajodia, Usha Goenka, Awanish Tiwari, Nikhil Sonthalia, Mahesh Goenka
PURPOSE: Liver stiffness measurement (LSM) by transient elastography has been shown to underperform in high-risk varices (HRVs) prediction in obese non-alcoholic fatty liver disease (NAFLD) compensated cirrhosis (CC). LSM by magnetic resonance elastography (MRE) and acoustic force radiation impulse (ARFI) has been shown to be useful in prediction of oesophageal varices (EVs), but has limited evidence in obese NAFLD-CC. METHODS: Obese patients with NAFLD-CC who underwent MRE and ARFI for LSM and endoscopy for screening of varices were enrolled...
April 23, 2024: Abdominal Radiology
#13
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#14
JOURNAL ARTICLE
XiMei Wang, FangZheng Yang, Zhi Sun, GuangHui Zhao, Qian Pu, ChenChen Geng, Ke Dong, XiaoDong Zhang, ZiQian Liu, HaiYun Song
Na, K-ATPase interaction (NKAIN) is a transmembrane protein family, which can interact with Na, K-ATPase β1 subunit. NKAIN1 plays an important role in alcohol-dependent diseases such as endometrial and prostate cancers. However, the relationship between NKAIN1 and human breast cancer has not been studied. Hence, this study aimed to explore the relationship between NKAIN1 expression and breast cancer. Data used in this study were mainly from the Cancer Genome Atlas, including differential expression analysis, Kaplan-Meier survival analysis, receiver operating characteristic curve analysis, multiple Cox regression analysis, co-expression gene analysis, and gene set enrichment analysis...
April 23, 2024: Molecular Carcinogenesis
#15
JOURNAL ARTICLE
Giovanna Coriale, Mauro Ceccanti, Marco Fiore, Francesca Tarani, Ginevra Micangeli, Michela Menghi, Adele Minutillo, Paolo Berretta, Giampiero Ferraguti, Angela Iannitelli, Giovanni Parlapiano, Roberto Paparella, Marisa Patrizia Messina, Mario Vitali, Daniela Fiorentino, Simona Pichini, Luigi Tarani
INTRODUCTION: Prenatal alcohol exposure causes a variety of impairments to the fetus called Fetal Alcohol Spectrum Disorders (FASD). Since it is very difficult to identify women that consume alcohol during pregnancy, different methods have been studied to evaluate alcohol exposure. Ethyl Glucuronide (EtG) and Fatty Acid Ethyl Esters (FAEEs) are commonly used to measure alcohol consumption in individuals at-risk for alcohol abuse, including pregnant women. MATERIALS AND METHODS: We conducted a study of two cohorts of 1...
2024: Rivista di Psichiatria
#16
JOURNAL ARTICLE
Axel Wester, Peter Jepsen, Hannes Hagström
BACKGROUND AND AIMS: Secondary prevention with statins improves clinical outcomes after myocardial infarction (MI). We aimed to compare odds of statin initiation after MI in patients with co-existing alcohol-related liver disease (ALD) to the general population, and the association between statin initiation and mortality in the patients with ALD. METHODS: All statin-naïve patients with ALD and a first-time MI between 2006 and 2020 were identified from Swedish healthcare registers and matched for age, sex, and year of MI with up to ten ALD-free general population controls with a first-time MI...
April 23, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#17
JOURNAL ARTICLE
Tugba Akkaya Hocagil, Louise M Ryan, Richard J Cook, Khue-Dung Dang, R Colin Carter, Gale A Richardson, Nancy L Day, Claire D Coles, Heather Carmichael Olson, Sandra W Jacobson, Joseph L Jacobson
While benchmark dose (BMD) methodology is well-established for settings with a single exposure, these methods cannot easily handle multidimensional exposures with nonlinear effects. We propose a framework for BMD analysis to characterize the joint effect of a two-dimensional exposure on a continuous outcome using a generalized additive model while adjusting for potential confounders via propensity scores. This leads to a dose-response surface which can be summarized in two dimensions by a contour plot in which combinations of exposures leading to the same expected effect are identified...
April 23, 2024: Risk Analysis: An Official Publication of the Society for Risk Analysis
#18
JOURNAL ARTICLE
Sebastiano Ortalli, Joseph Ford, Andrés A Trabanco, Matthew Tredwell, Véronique Gouverneur
Herein, we report a photoredox nucleophilic (radio)fluorination using TEMPO-derived alkoxyamines, a class of substrates accessible in a single step from a diversity of readily available carboxylic acids, halides, alkenes, alcohols, aldehydes, boron reagents, and C-H bonds. This mild and versatile one-electron pathway affords radiolabeled aliphatic fluorides that are typically inaccessible applying conventional nucleophilic substitution technologies due to insufficient reactivity and competitive elimination...
April 23, 2024: Journal of the American Chemical Society
#19
JOURNAL ARTICLE
Weikang Wang, Shaobin Mei, Shahid Khan, Yujue Hu, Lijuan Sun, Muhammad Adnan Qaiser, Chengzhang Zhu, Lele Wang, Qinqin Liu
Simultaneous utilization of photogenerated electrons and holes to achieve overall redox reactions is attractive but still far from practical application. The emerging step (S)-scheme mechanism has proven to be an ideal approach to inhibit charge recombination and supply photoinduced charges with highest redox potentials. Herein, a hierarchical phosphotungstic acid (H3PW12O40, HPW)@Znln2S4 (ZISW) heterojunction was prepared through one-pot hydrothermal method for simultaneous hydrogen (H2) evolution and benzyl alcohol upgrading...
April 23, 2024: ChemSusChem
#20
JOURNAL ARTICLE
Priyadarshini S Shettar, Murigendra B Hiremath
The aim of this study is to analyse the phytochemical composition, anti-oxidant activity, FT-IR and GC-MS analysis of Simarouba glauca leaf extracts. The chloroform extract exhibited highest T.P.C. (139.82 ± 0.06 mg/g GAE) and highest T.F.C. (41.95 ± 0.50 mg/g QE). The GC-MS analysis confirmed the presence of ten compounds in acetone extract and twenty-two compounds in methanol extract. The GC-MS analysis of acetone fraction showed the major peaks such as Glycerine (13...
April 23, 2024: Natural Product Research
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