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https://www.readbyqxmd.com/read/28938561/preventive-effects-of-the-sodium-glucose-cotransporter-2-inhibitor-tofogliflozin-on-diethylnitrosamine-induced-liver-tumorigenesis-in-obese-and-diabetic-mice
#1
Koki Obara, Yohei Shirakami, Akinori Maruta, Takayasu Ideta, Tsuneyuki Miyazaki, Takahiro Kochi, Hiroyasu Sakai, Takuji Tanaka, Mitsuru Seishima, Masahito Shimizu
Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease. In this study, we investigated the effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on the development of non-alcoholic fatty liver disease-related liver tumorigenesis in C57BL/KsJ-+Lepr (db) /+Lepr (db) obese and diabetic mice. The direct effects of tofogliflozin on human liver cancer cell proliferation were also evaluated...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938455/bile-acid-alterations-are-associated-with-insulin-resistance-but-not-with-nash-in-obese-subjects
#2
Vanessa Legry, Sven Francque, Joel T Haas, An Verrijken, Sandrine Caron, Oscar Chávez-Talavera, Emmanuelle Vallez, Luisa Vonghia, Eveline Dirinck, Ann Verhaegen, Mostafa Kouach, Sophie Lestavel, Philippe Lefebvre, Luc Van Gaal, Anne Tailleux, Réjane Paumelle, Bart Staels
Context: Bile acids (BA) are signalling molecules controlling energy homeostasis which can be both toxic and protective for the liver. BA alterations have been reported in obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). However whether BA alterations contribute to NASH independently of the metabolic status is unclear. Objective: To assess BA alterations associated with NASH independently of BMI and IR. Design & Setting: Patients visiting the obesity clinic of the Antwerp University Hospital (a tertiary referral facility) were recruited from 2006 to 2014...
August 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938229/prevalence-and-correlates-of-comorbid-depression-in-a-nonclinical-online-sample-with-dsm-5-internet-gaming-disorder
#3
Hee Ryung Wang, Hyun Cho, Dai-Jin Kim
BACKGROUND: We investigated the prevalence and correlates of comorbid depression among patients with internet gaming disorder using the Internet Gaming Disorder scale (IGD-9) and the Patient Health Questionnaire-9 (PHQ-9) among nonclinical online survey respondents. METHODS: Korean adolescents and adults from 14 to 39 years of age were selected. We compared internet gaming use patterns and sociodemographic and clinical variables between patients with internet gaming disorder who had depression and those without depression...
August 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28938185/gradient-of-association-between-parenting-styles-and-patterns-of-drug-use-in-adolescence-a-latent-class-analysis
#4
Juliana Y Valente, Hugo Cogo-Moreira, Zila M Sanchez
BACKGROUND: To identify different patterns of drug use in adolescence and determine if these are associated with parenting styles and other sociodemographic factors. METHODS: A latent class analysis was conducted using baseline data collected in a sample (n=6381) from a randomized controlled trial conducted to evaluate the effectiveness of the #Tamojunto drug-use prevention program, carried out with 7th- and 8th-grade public school students in six Brazilian cities...
September 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938184/preliminary-evidence-that-reactivity-to-uncertain-threat-is-an-endophenotype-for-alcohol-use-disorder
#5
Stephanie M Gorka, Stewart A Shankman
BACKGROUND: Having an exaggerated reactivity to threats that are uncertain (U-threat) may facilitate the initiation and maintenance of excessive alcohol use in some individuals. This abnormality may not just be a concomitant for alcohol use disorder (AUD), but also an endophenotype for AUD. METHOD: The aim of the current study was therefore to provide a preliminary test of whether U-threat is an endophenotype for AUD using several of the endophenotype criteria outlined by Gottesman and Gould (2003)...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938183/age-trends-in-rates-of-substance-use-disorders-across-ages-18-90-differences-by-gender-and-race-ethnicity
#6
Sara A Vasilenko, Rebecca J Evans-Polce, Stephanie T Lanza
BACKGROUND: Although research has documented age differences in substance use, less is known about how prevalence of substance use disorders (SUDs) vary across age and differ by gender and race/ethnicity. METHODS: Time-varying effect models (TVEMs) were estimated on data from the National Epidemiologic Survey of Alcohol and Related Conditions-III (NESARC III; N=36,309), a nationally representative survey of the adult population. The sample was 44% male; 53% White, 21% Black, 19% Hispanic/Latino, 6% other race/ethnicity...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938182/the-genetic-epidemiology-of-substance-use-disorder-a-review
#7
REVIEW
Elizabeth C Prom-Wormley, Jane Ebejer, Danielle M Dick, M Scott Bowers
BACKGROUND: Substance use disorder (SUD) remains a significant public health issue. A greater understanding of how genes and environment interact to regulate phenotypes comprising SUD will facilitate directed treatments and prevention. METHODS: The literature studying the neurobiological correlates of SUD with a focus on the genetic and environmental influences underlying these mechanisms was reviewed. Results from twin/family, human genetic association, gene-environment interaction, epigenetic literature, phenome-wide association studies are summarized for alcohol, nicotine, cannabinoids, cocaine, and opioids...
August 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938104/do-nurses-personal-health-behaviours-impact-on-their-health-promotion-practice-a-systematic-review
#8
REVIEW
Muireann Kelly, Jane Wills, Susie Sykes
BACKGROUND: There is a growing expectation in national and international policy and from professional bodies that nurses be role models for healthy behaviours, the rationale being that there is a relationship between nurses' personal health and the adoption of healthier behaviours by patients. This may be from patients being motivated by, and modelling, the visible healthy lifestyle of the nurse or that nurses are more willing to promote the health of their patients by offering public health or health promotion advice and referring the patient to support services...
August 23, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28937942/evaluating-the-effect-of-a-campus-wide-social-norms-marketing-intervention-on-alcohol-use-perceptions-consumption-and-blackouts
#9
Jinni Su, Linda Hancock, Amanda Wattenmaker McGann, Mariam Alshagra, Rhianna Ericson, Zackaria Niazi, Danielle M Dick, Amy Adkins
Objective To evaluate the effect of a campus-wide social norms marketing intervention on alcohol-use perceptions, consumption, and blackouts at a large, urban, public university. Participants 4,172 college students (1,208 freshmen, 1,159 sophomores, 953 juniors, 852 seniors) who completed surveys in Spring 2015 for the Spit for Science Study, a longitudinal study of students' substance use and emotional health. Methods Participants were emailed an online survey that queried campaign readership, perception of peer alcohol use, alcohol consumption, frequency of consumption and frequency of blackouts...
September 22, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28937921/internalizing-risk-factors-for-college-students-alcohol-use-a-combined-person-and-variable-centered-approach
#10
Stephanie E Wemm, Stephanie M Ernestus, Cathryn Glanton Holzhauer, Renata Vaysman, Edelgard Wulfert, Allen C Israel
BACKGROUND: Most studies that investigate internalizing problems (i.e., depression and anxiety symptoms) and alcohol use disorders use variable-centered approaches, losing important information about differences among individuals. OBJECTIVES: To group college students by different profiles of alcohol-use risk factors using a person-centered cluster analysis in two separate samples. METHODS: Questionnaires were used in both studies to assess positive expectancies regarding alcohol use, coping motives for alcohol use, and symptoms of depression and anxiety...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937912/postpartum-contraceptive-use-and-rapid-repeat-pregnancy-among-women-who-use-substances
#11
Amy M Loree, Aileen Gariepy, Jennifer Prah Ruger, Kimberly A Yonkers
BACKGROUND: Postpartum contraception is especially important for women who use alcohol and other substances, given the risk of possible rapid repeat pregnancy and prenatal substance exposure. However, little is known about postpartum contraceptive use among women with substance use histories. OBJECTIVE: To characterize postpartum contraceptive initiation, 24-month continuation, and rapid repeat pregnancy among women who used substances during pregnancy. METHODS: This is a secondary analysis of 161 pregnant women who enrolled in a randomized clinical trial to treat substance use in pregnancy and completed at least one follow-up assessment...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937874/can-a-label-help-me-drink-in-moderation-a-review-of-the-evidence-on-standard-drink-labelling
#12
Ashley Wettlaufer
INTRODUCTION: Understanding the concept of a standard drink (SD) is foundational knowledge to many public health policies aimed at reducing alcohol-related harms. These policies include adhering to low-risk drinking guidelines, screening brief intervention and referral activities, and counter alcohol-impaired driving initiatives. A lack of awareness of SDs might preclude the effectiveness of these interventions. A systematic review was conducted to review the evidence about how effective alcohol labels are in communicating SD information to the consumer...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937861/increased-suicides-during-new-year-but-not-during-christmas-in-sweden-analysis-of-cause-of-death-data-2006-2015
#13
Gergö Hadlaczky, Sebastian Hökby
BACKGROUND: Previous studies have investigated the impact of the Christmas and New Year holiday on suicide rates. However, no such data has yet been published on Swedish suicides. AIMS: To examine the occurrence of suicides on these dates in Sweden between 2006 and 2015. METHODS: The suicide count for each date between December 15th and January 15th was obtained from the Swedish cause of death registry. The observations were transformed to Z-scores to enable calculation of p-values...
September 22, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28937739/applications-of-iridium-catalyzed-asymmetric-allylic-substitution-reactions-in-target-oriented-synthesis
#14
Jianping Qu, Günter Helmchen
Metal catalyzed allylic substitution is a cornerstone of organometallic and synthetic chemistry. Enantioselective versions have been developed with catalysts derived from transition metals, most notably molybdenum, nickel, ruthenium, rhodium, iridium, palladium, and copper. The palladium- and the iridium-catalyzed versions have turned out to be particularly versatile in organic synthesis because of the very broad scope of the nucleophile and great functional group compatibility. Assets of the iridium-catalyzed reaction are the formation of branched, chiral products from simple monosubstituted allylic substrates, high degrees of regio- and enantioselectivity, and use of modular, readily available chiral ligands...
September 22, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28937693/genome-wide-association-study-of-alcohol-consumption-and-genetic-overlap-with-other-health-related-traits-in-uk-biobank-n-112%C3%A2-117
#15
T-K Clarke, M J Adams, G Davies, D M Howard, L S Hall, S Padmanabhan, A D Murray, B H Smith, A Campbell, C Hayward, D J Porteous, I J Deary, A M McIntosh
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals...
October 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28937625/one-pot-multi-enzymatic-synthesis-of-the-four-stereoisomers-of-4-methylheptan-3-ol
#16
Elisabetta Brenna, Michele Crotti, Francesco G Gatti, Daniela Monti, Fabio Parmeggiani, Andrea Pugliese
The use of pheromones in the integrated pest management of insects is currently considered a sustainable and environmentally benign alternative to hazardous insecticides. 4-Methylheptan-3-ol is an interesting example of an insect pheromone, because its stereoisomers are active towards different species. All four possible stereoisomers of this compound were prepared from 4-methylhept-4-en-3-one by a one-pot procedure in which the two stereogenic centres were created during two sequential reductions catalysed by an ene-reductase (ER) and an alcohol dehydrogenase (ADH), respectively...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937622/specificities-of-human-hepatocellular-carcinoma-developed-on-non-alcoholic-fatty-liver-disease-in-absence-of-cirrhosis-revealed-by-tissue-extracts-%C3%A2-h-nmr-spectroscopy
#17
Camille Teilhet, Daniel Morvan, Juliette Joubert-Zakeyh, Anne-Sophie Biesse, Bruno Pereira, Sylvie Massoulier, Pierre Dechelotte, Denis Pezet, Emmanuel Buc, Géraldine Lamblin, Michel Peoc'h, Jack Porcheron, Marie-Paule Vasson, Armando Abergel, Aicha Demidem
There is a rising incidence of non-alcoholic fatty liver disease (NAFLD) as well as of the frequency of Hepato-Cellular Carcinoma (HCC) associated with NAFLD. To seek for putative metabolic pathways specific of the NAFLD etiology, we performed comparative metabolomics between HCC associated with NAFLD and HCC associated with cirrhosis. The study included 28 pairs of HCC tissue versus distant Non-Tumoral Tissue (NTT) collected from patients undergoing hepatectomy. HCC was associated with cirrhosis (n = 9), normal liver (n = 6) and NAFLD (n = 13)...
September 22, 2017: Metabolites
https://www.readbyqxmd.com/read/28937617/comparison-of-patterns-of-use-of-unrecorded-and-recorded-spirits-survey-of-adult-drinkers-in-rural-central-china
#18
Shiqing Wei, Ping Yin, Ian M Newman, Ling Qian, Duane F Shell, Lok-Wa Yuen
About 70% of the beverage alcohol consumed in China annually is spirits. Recorded spirits make up most spirit consumption, but about 25% of total alcohol consumption (1.7 L pure alcohol per capita annually) is unrecorded spirits (bai jiu), either homemade or made in unregulated distilleries. In some parts of China, the consumption of unrecorded spirits is higher than average. This paper compares the patterns of use of unrecorded distilled spirits and recorded distilled spirits among rural residents in Central China...
September 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28937599/mediterranean-diet-and-multi-ingredient-based-interventions-for-the-management-of-non-alcoholic-fatty-liver-disease
#19
REVIEW
Manuel Suárez, Noemí Boqué, Josep M Del Bas, Jordi Mayneris-Perxachs, Lluís Arola, Antoni Caimari
Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical exercise. In this framework, there is increasing evidence that several food bioactives and dietary patterns are effective for reversing and preventing the onset of these pathologies...
September 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28937577/trajectories-of-musculoskeletal-pain-from-adolescence-to-middle-age-the-role-of-early-depressive-symptoms-a-27-year-follow-up-of-the-northern-swedish-cohort
#20
Päivi Leino-Arjas, Kristiina Rajaleid, Gashaw Mekuria, Tapio Nummi, Pekka Virtanen, Anne Hammarström
Depression and musculoskeletal pain are associated, but long-term follow-up studies are rare. We aimed to examine the relationship of early depressive symptoms with developmental patterns of musculoskeletal pain from adolescence to middle age. Adolescents ending compulsory school (age 16) in Luleå, Northern Sweden, in 1981 (n = 1083) were studied and followed up in 1986, 1995, and 2008 (age 43) for musculoskeletal pain. Attrition was very low. Indicators for any and severe pain were based on pain in the neck-shoulders, low back, and the extremities...
September 19, 2017: Pain
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