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pediatric experimental study

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https://www.readbyqxmd.com/read/28422949/heparin-binding-egf-like-growth-factor-promotes-neuronal-nitric-oxide-synthase-expression-and-protects-the-enteric-nervous-system-after-necrotizing-enterocolitis
#1
Yu Zhou, Yijie Wang, Jacob Olson, Jixin Yang, Gail E Besner
BACKGROUND: Neonatal necrotizing enterocolitis (NEC) is associated with alterations of the ENS, with loss of neuronal nitric oxide synthase (nNOS) expressing neurons in the intestine. The aims of this study were to investigate the roles of heparin binding EGF-like growth factor (HB-EGF) in neural stem cell (NSC) differentiation, nNOS expression, and effects on ENS integrity during experimental NEC. METHODS: The effects of HB-EGF on NSC differentiation and nNOS production were determined using cultured enteric NSC...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28409853/a-phase-1-study-of-the-cxcr4-antagonist-plerixafor-in-combination-with-high-dose-cytarabine-and-etoposide-in-children-with-relapsed-or-refractory-acute-leukemias-or-myelodysplastic-syndrome-a-pediatric-oncology-experimental-therapeutics-investigators-consortium
#2
Todd M Cooper, Edward Allan Racela Sison, Sharyn D Baker, Lie Li, Amina Ahmed, Tanya Trippett, Lia Gore, Margaret E Macy, Aru Narendran, Keith August, Michael J Absalon, Jessica Boklan, Jessica Pollard, Daniel Magoon, Patrick A Brown
BACKGROUND: Plerixafor, a reversible CXCR4 antagonist, inhibits interactions between leukemic blasts and the bone marrow stromal microenvironment and may enhance chemosensitivity. A phase 1 trial of plerixafor in combination with intensive chemotherapy in children and young adults with relapsed or refractory acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) was performed to determine a tolerable and biologically active dose. PROCEDURE: Plerixafor was administered daily for 5 days at four dose levels (6, 9, 12, and 15 mg/m(2) /dose) followed 4 hr later by high-dose cytarabine (every 12 hr) and etoposide (daily)...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28400860/multiple-etiologies-of-infectious-diarrhea-and-concurrent-infections-in-a-pediatric-outpatient-based-screening-study-in-odisha-india
#3
Arpit Kumar Shrivastava, Subrat Kumar, Nirmal Kumar Mohakud, Mrutyunjay Suar, Priyadarshi Soumyaranjan Sahu
BACKGROUND: There are multiple etiologies responsible for infectious gastroenteritis causing acute diarrhea which are often under diagnosed. Also acute diarrhea is one of the major causes of morbidity and mortality among children less than 5 years of age. METHODS: In our study, fecal samples (n = 130) were collected from children (<5 years) presenting with symptoms of acute diarrhea. Samples were screened for viral, bacterial, and parasitic etiologies. Rotavirus and Adenovirus were screened by immunochromatographic tests...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28395016/impact-of-commercial-computerized-provider-order-entry-cpoe-and-clinical-decision-support-systems-cdsss-on-medication-errors-length-of-stay-and-mortality-in-intensive-care-units-a-systematic-review-and-meta-analysis
#4
Mirela Prgomet, Ling Li, Zahra Niazkhani, Andrew Georgiou, Johanna I Westbrook
Objective: To conduct a systematic review and meta-analysis of the impact of commercial computerized provider order entry (CPOE) and clinical decision support systems (CDSSs) on medication errors, length of stay (LOS), and mortality in intensive care units (ICUs). Methods: We searched for English-language literature published between January 2000 and January 2016 using Medline, Embase, and CINAHL. Titles and abstracts of 586 unique citations were screened. Studies were included if they: (1) reported results for an ICU population; (2) evaluated the impact of CPOE or the addition of CDSSs to an existing CPOE system; (3) reported quantitative data on medication errors, ICU LOS, hospital LOS, ICU mortality, and/or hospital mortality; and (4) used a randomized controlled trial or quasi-experimental study design...
March 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28387491/-experimental-study-on-the-intolerance-of-uncertainty-and-cognitive-biases-in-parents-of-child-cancer-survivor
#5
M Vander Haegen, A M Etienne, C Piette
Studies in pediatric oncology describe a relative good quality of life in child cancer survivor. However, few studies were interested in the parents of a child cancer survivor. 61 parents are recruited in the Belgian hospitals. Three groups of parents are constituted : the parents whose child is in 4 years of survivorship (group 1), in 5 years of survivorship (group 2) and in 6 years of survivorship (group 3). Clinical scales and a Stroop emotion task are administered. Parents (of the 3 groups) present a low tolerance of uncertainty, have excessive worries about the evolution of the health of their child, and suffer from anxious symptoms...
March 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28382056/effect-of-implementation-of-continuous-care-model-on-mothers-anxiety-of-the-children-discharged-from-the-pediatric-surgical-unit
#6
Forogh Okhovat, Zahra Abdeyazdan, Mahboobeh Namnabati
INTRODUCTION: Child's hospitalization for surgery is a source of anxiety for the child and the family that persists for a long time after discharge. Therefore, it is necessary to provide appropriate solutions in this regard. This study aimed to investigate the effect of implementation of continuous care model on anxiety in mothers of children discharged from pediatric units of educational hospitals of Isfahan University of Medical Sciences in 2016. MATERIALS AND METHODS: In this quasi-experimental study, 64 mothers of children hospitalized in surgical units were categorized in two groups (experimental and control)...
January 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28377649/comparative-evaluation-of-clinical-and-radiographic-success-of-formocresol-propolis-turmeric-gel-and-calcium-hydroxide-on-pulpotomized-primary-molars-a-preliminary-study
#7
Shivayogi M Hugar, Pratibha Kukreja, Shweta S Hugar, Niraj Gokhale, Harsha Assudani
AIMS: Despite various advents in technology, the present era marks a shift to phytotherapeutics and alternative modalities to conventional endodontic treatments. Newer endodontic modalities have been developed inculcating the ancient system of medicine. The present study was done to compare and evaluate the clinical pulp response and radiographic signs after pulpotomy in four groups of primary molar teeth treated with formocresol (control), propolis extract, turmeric gel, and calcium hydroxide respectively...
January 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28372803/ultrasound-guided-dissection-and-ligation-of-the-internal-inguinal-ring-for-hernia-repair-in-pediatrics-an-experimental-animal-study
#8
Pedro Reino-Pires, José Miguel Pêgo, Alice Miranda, Catarina Barroso, Margarida España, Jorge Correia-Pinto
PURPOSE: We aimed to test the feasibility and reliability of ultrasound-guided percutaneous internal inguinal ring suture in rabbits, as a model for inguinal hernia repair in pediatric population. METHODS: Twenty-eight rabbits were divided in 2 groups: group I (female morphology) - persistence of the peritoneal-vaginal duct with gonads placed in intraperitoneal position; group II (male morphology) - persistence of the peritoneal-vaginal duct with gonads kept intact inside the duct...
March 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28361405/impact-of-safety-related-regulations-on-codeine-use-in-children-a-quasi-experimental-study-using-taiwan-s-national-health-insurance-research-database
#9
Chih-Wan Lin, Ching-Huan Wang, Wei-I Huang, Wei-Ming Ke, Pi-Hui Chao, Wen-Wen Chen, Fei-Yuan Hsiao
INTRODUCTION: Safety concerns regarding potential life-threatening adverse events associated with codeine have resulted in policy decisions to restrict its use in pediatrics. However, whether these drug safety communications have had an immediate and strong impact on codeine use remains in question. OBJECTIVE: We aimed to investigate the impact of the two implemented safety-related regulations (label changes and reimbursement regulations) on the use of codeine for upper respiratory infection (URI) or cough...
March 30, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28359333/the-immune-regulating-effect-of-xiao-er-qixingcha-in-constipated-mice-induced-by-high-heat-and-high-protein-diet
#10
Chang Qu, Guang-Hua Yang, Rong-Bo Zheng, Xiu-Ting Yu, Shao-Zhong Peng, Jian-Hui Xie, Jian-Nan Chen, Xiu-Fen Wang, Zi-Ren Su, Xiao-Jun Zhang
BACKGROUND: Xiao'er Qixingcha (EXQ) has been extensively applied to relieve dyspepsia and constipation in children for hundreds of years in China. However, the therapeutic mechanism underlying its efficacy remained to be defined. The present study aimed to clarify the possible laxative and immune-regulating effects of EXQ on two models of experimental constipation in mice, which mimicked the pediatric constipation caused by high-heat and high-protein diet (HHPD). METHODS: The two models of constipated mice were induced by HHPD or HHPD + atropine respectively...
March 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28347627/simulation-guided-navigation-for-vector-control-in-pediatric-mandibular-distraction-osteogenesis
#11
Giovanni Badiali, Fabrizio Cutolo, Andrea Roncari, Claudio Marchetti, Alberto Bianchi
AIM: Navigation technology has given surgeons the capacity to know precisely where their instruments are during surgery, and simulation-guided navigation is a surgical method which is based on the use of navigation technology linked to 3D virtual surgery simulation. The aim of the present study was to evaluate the absolute accuracy of simulation-guided navigation as an aid to reproduce the planned position of the distraction device vector in pediatric mandibular distraction osteogenesis...
February 14, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28343636/interruptions-in-preanesthesia-nursing-workflow-a-pilot-study-of-pediatric-patient%C3%A2-safety
#12
Heidi M Filer, Brooke L Beringuel, Kathleen M Frato, Mary K Anthony, Pimpanitta Saenyakul
PURPOSE: Preanesthesia care is a high-risk system where interruptions during the preanesthesia assessment may jeopardize the quality of information obtained. The objective of this study was to (1) identify the number and nature of interruptions occurring during the nursing preanesthesia assessment, (2) evaluate effectiveness of a no interruption zone (NIZ) on the number and nature of interruptions experienced, and (3) determine the frequency with which nurses returned to their original task after interruption...
April 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28339377/stability-of-clindamycin-hydrochloride-in-pcca-base-suspendit
#13
Yashoda V Pramar, Richard A Graves, Grace A Ledet, Kelly V Phan, Levon A Bostanian, Tarun K Mandal
Clindamycin is an effective antibiotic in the treatment of infections caused by certain gram-positive and gram-negative anaerobic microorganisms. While manufactured forms of the drug for pediatric use are available, there are instances when a compounded liquid dosage form is essential to meet unique patient needs. The purpose of this study was to determine the chemical stability of clindamycin hydrochloride in the PCCA base SuspendIt, a sugar-free, paraben- free, dye-free, and gluten-free thixotropic vehicle containing a natural sweetener obtained from the monk fruit...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28328807/associations-of-il-4-il-6-and-il-12-levels-in-peripheral-blood-with-lung-function-cellular-immune-function-and-quality-of-life-in-children-with-moderate-to-severe-asthma
#14
Ai-Hua Cui, Jing Zhao, Shu-Xiang Liu, Ying-Shuang Hao
BACKGROUND: Pediatric asthma has gained increasing concerns with poorly understood pathogenesis. The purpose of this study was to explore the associations of interleukin-4 (IL-4), IL-6, and IL-12 levels in peripheral blood (PB) with lung function, cellular immune function, and children's quality of life (QOL) with moderate-to-severe asthma. METHODS: A total of 1158 children with moderate-to-severe asthma (the experimental group) and 1075 healthy children (the control group) were recruited for our study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28324682/gene-expression-analysis-in-untreated-absence-epilepsy-demonstrates-an-inconsistent-pattern
#15
Markus von Deimling, Robert Häsler, Verena Steinbach, Paul-Martin Holterhus, Sarah von Spiczak, Ulrich Stephani, Ingo Helbig, Hiltrud Muhle
OBJECTIVE: Childhood and Juvenile Absence Epilepsy account for 30% of all genetic generalized epilepsies with a strong genetic contribution. At the current state the genetic background remains to be resolved. The aim of this study was to identify disease associated transcripts pinpointing potential underlying disease mechanisms in patients with CAE and JAE. METHODS: We performed gene expression analysis from peripheral blood mononuclear cells (PBMCs) in 30 patients with newly-diagnosed absence epilepsy prior to initiating treatment and 30 healthy age - and gender-matched pediatric controls...
February 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28319067/the-histone-demethylase-kdm3a-and-its-downstream-target-mcam-promote-ewing-sarcoma-cell-migration-and-metastasis
#16
M Sechler, J K Parrish, D K Birks, P Jedlicka
Ewing Sarcoma is the second most common solid pediatric malignant neoplasm of bone and soft tissue. Driven by EWS/Ets, or rarely variant, oncogenic fusions, Ewing Sarcoma is a biologically and clinically aggressive disease with a high propensity for metastasis. However, the mechanisms underpinning Ewing Sarcoma metastasis are currently not well understood. In the present study, we identify and characterize a novel metastasis-promotional pathway in Ewing Sarcoma, involving the histone demethylase KDM3A, previously identified by our laboratory as a new cancer-promoting gene in this disease...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28288145/rectal-temperature-in-the-first-five-hours-after-hypoxia-ischaemia-critically-affects-neuropathological-outcomes-in-neonatal-rats
#17
Thomas Wood, Catherine Hobbs, Mari Falck, Anne Charlotte Brun, Else Marit Løberg, Marianne Thoresen
BACKGROUND: Hyperthermia after hypoxia-ischaemia (HI) in newborn infants is associated with worse neurological outcomes. Loss of thermoregulation may also be associated with greater injury. METHODS: In the postnatal-day 7 (P7) rat, the effect of 5h of graded hyperthermia (38°C or 39°C) immediately after unilateral HI was compared to normothermia (NT, 37°C), and therapeutic hypothermia (TH, 32°C). Early (negative geotaxis) and late (staircase test) behavioural testing was performed, as well as neuropathology scoring in adulthood...
March 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28277380/update-on-developmental-anesthesia-neurotoxicity
#18
Laszlo Vutskits, Andrew Davidson
PURPOSE OF REVIEW: Adverse long-term impact of general anesthesia on the developing brain is a widely discussed and controversial issue with potential public health relevance. The goal of this article is to give insights into the most recent experimental and clinical observations aimed to advance our understanding in this field. RECENT FINDINGS: Recent investigations demonstrate long-term behavioral consequences of early-life anesthesia exposure in nonhuman primates under experimental conditions that are translationally relevant to human clinical practice...
March 8, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28264082/effects-of-advice-to-drink-8-cups-of-water-per-day-in-adolescents-with-overweight-or-obesity-a-randomized-clinical-trial
#19
Julia M W Wong, Cara B Ebbeling, Lisa Robinson, Henry A Feldman, David S Ludwig
Importance: Health care professionals commonly recommend increased water consumption, typically to 8 cups per day, as part of a weight-reducing diet. However, this recommendation is based on limited evidence and virtually no experimental data from the pediatric population. Objective: To compare 2 standardized weight-loss diets among adolescents with overweight or obesity, either with or without additional advice and behavioral support to increase habitual water intake to 8 cups per day...
March 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28261399/validity-and-reliability-of-a-tool-to-assess-quality-improvement-knowledge-and-skills-in-pediatrics-residents
#20
Stephanie K Doupnik, Sonja I Ziniel, Eric W Glissmeyer, James M Moses
BACKGROUND : Residency programs are expected to educate residents in quality improvement (QI). Effective assessments are needed to ensure residents gain QI knowledge and skills. Limitations of current tools include poor interrater reliability and requirement for scorer training. OBJECTIVE : To provide evidence for the validity of the Assessment of Quality Improvement Knowledge and Skills (AQIKS), which is a new tool that provides a summative assessment of pediatrics residents' ability to recall QI concepts and apply them to a clinical scenario...
February 2017: Journal of Graduate Medical Education
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