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pediatric experimental study

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https://www.readbyqxmd.com/read/28224606/single-subject-research-designs-in-pediatric-rehabilitation-a-valuable-step-towards-knowledge-translation
#1
REVIEW
Lynne Romeiser-Logan, Rebecca Slaughter, Robbin Hickman
Knowledge translation may be particularly challenging in pediatric rehabilitation, where study findings are often ambiguous owing to low statistical power or inconsistent responses to intervention. Disconnection between research protocols and clinical practicality, as well as variability of responsiveness in heterogeneous pediatric populations, may further impede integration of research findings into everyday practice. Use of single-subject research designs (SSRDs) may bridge the gap between research and practice, with robust design options that better identify and preserve patterns of responsiveness to specific interventions and offer protocols that are more readily implemented in practice settings than can be done in traditional randomized controlled trials...
February 22, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28209260/use-of-the-pasero-opioid-induced-sedation-scale-poss-in-pediatric-patients
#2
Ann Quinlan-Colwell, Gayle Thear, Emily Miller-Baldwin, Andrea Smith
The Pasero Opioid-induced Sedation Scale (POSS) is a valid, reliable tool used to assess sedation when administering opioid medications to manage pain. The POSS is endorsed by The Joint Commission and the American Society for Pain Management Nursing to help prevent adverse opioid-related respiratory events. Although the POSS is used to assess sedation in pediatric patients at some hospitals, prior to this study, it was not formally evaluated in the pediatric population. This study used a quasi-experimental design with a convenience sample of pediatric patients admitted to a large regional medical center in southeastern North Carolina...
February 10, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28184367/novel-immunotherapies-for-autoimmune-hepatitis
#3
REVIEW
Shamir Cassim, Marc Bilodeau, Catherine Vincent, Pascal Lapierre
Autoimmune hepatitis (AIH) is a multifactorial autoimmune disease of unknown pathogenesis, characterized by a loss of immunological tolerance against liver autoantigens resulting in the progressive destruction of the hepatic parenchyma. Current treatments are based on non-specific immunosuppressive drugs. Although tremendous progress has been made using specific biological agents in other inflammatory diseases, progress has been slow to come for AIH patients. While current treatments are successful in the majority of patients, treatment discontinuation is difficult to achieve, and relapses are frequent...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28183322/impact-of-a-pharmacist-led-medication-review-on-hospital-readmission-in-a-pediatric-and-elderly-population-study-protocol-for-a-randomized-open-label-controlled-trial
#4
Pierre Renaudin, Karine Baumstarck, Aurélie Daumas, Marie-Anne Esteve, Stéphane Gayet, Pascal Auquier, Michel Tsimaratos, Patrick Villani, Stéphane Honore
BACKGROUND: Early hospital readmission of patients after discharge is a public health problem. One major cause of hospital readmission is dysfunctions in integrated pathways between community and hospital care that can cause adverse drug events. Furthermore, the French ENEIS 2 study showed that 1.3% of hospital stays originated from serious adverse drug events in 2009. Pharmacy-led medication reviews at hospital transitions are an effective means of decreasing medication discrepancies when conducted at admission or discharge...
February 9, 2017: Trials
https://www.readbyqxmd.com/read/28177675/what-factors-contribute-to-the-elevation-of-serum-free-fatty-acids-ffa-in-newborns-in-the-cardiac-surgical-setting
#5
Carin Wittnich, Michael P Belanger
Elevations in serum free fatty acids (FFA) levels during heart surgery have been reported in humans and experimental animals, causing increased arrhythmias, decreased heart function, and contributing to mortality. Factors such as heparin administration, age, cardiopulmonary bypass (CPB) and cyanosis/hypoxia have been implicated but not proven. This study was designed to clarify the contribution of these factors using an experimental pig model as follows: a) adult (n=10) versus 3-day old piglets (n=18) had FFA levels assessed before and after heparin administration; b) 3 day old piglets, the additional effect of CPB (n=8) or just severe hypoxia (PaO2 = 20-25 mmHg; n=6) exposure on FFA levels...
January 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28161474/the-impact-of-parental-modeling-on-child-pain-responses-the-role-of-parent-and-child-sex
#6
Katelynn E Boerner, Christine T Chambers, Patrick J McGrath, Vincent LoLordo, Rudolf Uher
: Social modeling is a process by which pain behaviours are learned, and research has found parents act as models for their children's behaviour. Despite social learning theory predicting that same-sex models have greater impact, no experimental investigation to date has examined the role of sex of the model or observer in social learning of pediatric pain. The present study recruited 168 parent-child dyads (equal father-son, father-daughter, mother-son, and mother-daughter dyads) where children were generally healthy 6- to 8-year-olds...
February 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28146013/a-practice-guideline-for-postreduction-management-of-intussusception-of-children-in-the-emergency-department
#7
Hyuksool Kwon, Jin Hee Lee, Jin Hee Jeong, Hye Ran Yang, Young Ho Kwak, Do Kyun Kim, Kyuseok Kim
OBJECTIVES: The aim of this study was to evaluate the effects of a practice guideline of postreduction management of intussusception in children on the length of stay (LOS) from reduction in the pediatric emergency department (PED) and on the incidence of recurrence. METHODS: We developed a practice guideline of postreduction management of intussusception in the PED. The practice guideline involved feeding 2 hours after reduction and discharge 2 hours after successful feeding...
January 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28130195/minimizing-noise-in-pediatric-task-based-functional-mri-adolescents-with-developmental-disabilities-and-typical-development
#8
Catherine Fassbender, Prerona Mukherjee, Julie B Schweitzer
Functional Magnetic Resonance Imaging (fMRI) represents a powerful tool with which to examine brain functioning and development in typically developing pediatric groups as well as children and adolescents with clinical disorders. However, fMRI data can be highly susceptible to misinterpretation due to the effects of excessive levels of noise, often related to head motion. Imaging children, especially with developmental disorders, requires extra considerations related to hyperactivity, anxiety and the ability to perform and maintain attention to the fMRI paradigm...
January 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28125932/brief-cognitive-behavioral-intervention-for-children-and-adolescents-with-persistent-post-concussive-symptoms-a-pilot-study
#9
Kelly A McNally, Kristina E Patrick, Jacob E LaFleur, Jana B Dykstra, Kerry Monahan, Kristen R Hoskinson
This study aims to evaluate the efficacy of a brief cognitive behavioral intervention program for children and adolescents experiencing persistent post-concussion symptoms. A total of 31 patients aged 10 to 18 years participated in the intervention. The median time since injury at treatment onset was 95 days though the range was large (23-720 days). Treatment was on average four sessions in duration. Sessions included concussion education, activity scheduling, sleep hygiene relaxation training, and cognitive restructuring...
January 26, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28119350/a-systematic-review-of-management-strategies-for-children-s-mental-health-care-in-the-emergency-department-update-on-evidence-and-recommendations-for-clinical-practice-and-research
#10
Amanda S Newton, Lisa Hartling, Amir Soleimani, Scott Kirkland, Michele P Dyson, Mario Cappelli
OBJECTIVE: Children with mental health crises require access to specialised resources and services which are not yet standard in general and paediatric EDs. In 2010, we published a systematic review that provided some evidence to support the use of specialised care models to reduce hospitalisation, return ED visits and length of ED stay. We perform a systematic review to update the evidence base and inform current policy statements. METHODS: Twelve databases and the grey literature were searched up to January 2015...
January 24, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28109735/implementation-and-evaluation-of-two-educational-strategies-to-improve-screening-for-eating-disorders-in-pediatric-primary-care
#11
Holly C Gooding, Elizabeth Cheever, Sara F Forman, Jonathan Hatoun, Farah Jooma, Currie Touloumtzis, Louis Vernacchio
PURPOSE: Routine screening for disordered eating or body image concerns is recommended by the American Academy of Pediatrics. We evaluated the ability of two educational interventions to increase screening for eating disorders in pediatric primary care practice, predicting that the "active-learning" group would have an increase in documented screening after intervention. METHODS: We studied 303 practitioners in a large independent practice association located in the northeastern United States...
January 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28105858/hplc-ms-ms-method-for-dexmedetomidine-quantification-with-design-of-experiments-approach-application-to-pediatric-pharmacokinetic-study
#12
Oliwia Szerkus, Wiktoria Struck-Lewicka, Marta Kordalewska, Ewa Bartosińska, Renata Bujak, Agnieszka Borsuk, Agnieszka Bienert, Alicja Bartkowska-Śniatkowska, Justyna Warzybok, Paweł Wiczling, Antoni Nasal, Roman Kaliszan, Michał Jan Markuszewski, Danuta Siluk
AIM: The purpose of this work was to develop and validate a rapid and robust LC-MS/MS method for the determination of dexmedetomidine (DEX) in plasma, suitable for analysis of a large number of samples. METHOD: Systematic approach, Design of Experiments, was applied to optimize ESI source parameters and to evaluate method robustness, therefore, a rapid, stable and cost-effective assay was developed. The method was validated according to US FDA guidelines. LLOQ was determined at 5 pg/ml...
February 2017: Bioanalysis
https://www.readbyqxmd.com/read/28099351/effectiveness-of-a-radiation-reduction-campaign-targeting-children-with-gastrointestinal-symptoms-in-a-pediatric-emergency-department
#13
Hyuksool Kwon, Jae Yun Jung
Children feature more active cellular division and a smaller body area, which leads to a greater radiation dosage accumulation. We tried to reduce radiation hazards by reducing unnecessary radiological studies in a pediatric emergency department (PED) through the radiation reduction campaign.Our campaign involved a reduction from 2 (erect and supine) to 1 ordered abdominal plain radiograph (erect). This quasi-experimental, uncontrolled before-and-after study aimed to evaluate the campaign effect. We compared simple radiograph orders, length of stay (LOS) in PED, and return visit (RV) to PED between the before period (June 1, 2011-May 30, 2014) and the after period (June 1, 2014-May 30, 2015)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098954/use-of-play-therapy-in-nursing-process-a-prospective-randomized-controlled-study
#14
Emel Sezici, Ayse Ferda Ocakci, Hasibe Kadioglu
PURPOSE: Play therapy is a nursing intervention employed in multidisciplinary approaches to develop the social, emotional, and behavioral skills of children. In this study, we aim to determine the effects of play therapy on the social, emotional, and behavioral skills of pre-school children through the nursing process. DESIGN: A single-blind, prospective, randomized controlled study was undertaken. The design, conduct, and reporting of this study adhere to the Consolidated Standards of Reporting Trials (CONSORT) guidelines...
January 18, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28095378/advanced-neuroimaging-techniques-in-pediatric-hydrocephalus
#15
Smruti K Patel, Weihong Yuan, Francesco T Mangano
From the early days of pneumoencephalography and ventriculography to the emerging technology of magnetic resonance diffusion tensor imaging (DTI) of the present day, neuroimaging has always been a critical tool in the diagnosis and treatment of pediatric hydrocephalus. There is accumulating evidence from both human and animal research suggesting that one of the major pathophysiological mechanisms underlying poor outcomes in these children is damage to vulnerable white matter (WM) structures in the brain as a result of ventricular enlargement and increased intracranial pressure...
January 18, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28079793/oral-health-related-quality-of-life-in-pediatric-patients-under-general-anesthesia-a-prospective-study
#16
Lanlan Li, Hongwei Wang, Xueping Han
Our goal was to evaluate how dental treatments under general anesthesia (GA) affect the quality of life by a prospective pair-matched design. Pediatric patients, who had received dental treatments under GA, were enrolled and were asked to complete the Early Childhood Oral Health Impact Scale (ECOHIS) before the treatment and 1 month after the treatment. To shield the observed impacts, a pair-matched control group was performed. Patients in the control group were also required to complete the ECOHIS at these different points in time...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072667/does-the-use-of-a-vein-visualization-device-for-peripheral-venous-catheter-placement-increase-success-rate-in-pediatric-patients
#17
Duygu Demir, Sevil Inal
BACKGROUND: Peripheral intravenous catheterization is one of the most frequently encountered medical procedures for hospitalized children and is one that can often be painful. Pediatric nurses should therefore use techniques that increase the success rate or shorten the duration of peripheral intravenous catheterization. OBJECTIVES: This study was performed with the objective of determining the effect of using a vein visualization device on the success of the procedure...
February 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28070685/porcine-spine-finite-element-model-a-complementary-tool-to-experimental-scoliosis-fusionless-instrumentation
#18
Bahe Hachem, Carl-Eric Aubin, Stefan Parent
PURPOSE: Developing fusionless devices to treat pediatric scoliosis necessitates lengthy and expensive animal trials. The objective was to develop and validate a porcine spine numerical model as an alternative platform to assess fusionless devices. METHODS: A parametric finite element model (FEM) of an osseoligamentous porcine spine and rib cage, including the epiphyseal growth plates, was developed. A follower-type load replicated physiological and gravitational loads...
January 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28048636/tu-fg-brb-04-a-new-optimization-method-for-pre-treatment-patient-specific-stopping-power-by-combining-proton-radiography-and-x-ray-ct
#19
C Collins-Fekete, R Schulte, L Beaulieu, J Seco
PURPOSE: The relative stopping power (RSP) uncertainty is the largest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate patient specific RSPs by combining pre-treatment X-ray CT and daily proton radiography. METHODS: The method is formulated as a penalized least squares optimization (PLSO) problem min(|Ax-B|). The matrix A represents the cumulative path-length crossed in each material computed by calculating proton trajectories through the X-ray CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048468/su-d-209-06-study-on-the-dose-conversion-coefficients-in-pediatric-radiography-with-the-development-of-children-voxel-phantoms
#20
Q Liu, W Zhuo, H Liu, Y Liu, T Chen
PURPOSE: Conversion coefficients of organ dose normalized to entrance skin dose (ESD) are widely used to evaluate the organ doses directly using ESD without time-consuming dose measurement, this work aims to investigate the dose conversion coefficients in pediatric chest and abdomen radiography with the development of 5 years and 10 years old children voxel phantoms. METHODS: After segmentation of organs and tissues from CT slice images of ATOM tissue-equivalent phantoms, a 5-year-old and a 10-year-old children computational voxel phantoms were developed for Monte Carlo simulation...
June 2016: Medical Physics
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