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influenza A

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https://www.readbyqxmd.com/read/28231295/the-pathogens-profile-in-children-with-otitis-media-with-effusion-and-adenoid-hypertrophy
#1
G P Buzatto, E Tamashiro, J L Proenca-Modena, T H Saturno, M C Prates, T B Gagliardi, L R Carenzi, E T Massuda, M A Hyppolito, F C P Valera, E Arruda, W T Anselmo-Lima
OBJECTIVES: To evaluate the presence of viruses and bacteria in middle ear and adenoids of patients with and without otitis media with effusion (OME). METHODS: Adenoid samples and middle ear washes (MEW) were obtained from children with OME associated with adenoid hypertrophy undergoing adenoidectomy and tympanostomy, and compared to those obtained from patients undergoing cochlear implant surgery, as a control group. Specific DNA or RNA of 9 respiratory viruses (rhinovirus, influenza virus, picornavirus, syncytial respiratory virus, metapneumovirus, coronavirus, enterovirus, adenovirus and bocavirus) and 5 bacteria (S...
2017: PloS One
https://www.readbyqxmd.com/read/28231239/surveillance-for-health-care-access-and-health-services-use-adults-aged-18-64-years-behavioral-risk-factor-surveillance-system-united-states-2014
#2
Catherine A Okoro, Guixiang Zhao, Jared B Fox, Paul I Eke, Kurt J Greenlund, Machell Town
PROBLEM/CONDITION: As a result of the 2010 Patient Protection and Affordable Care Act, millions of U.S. adults attained health insurance coverage. However, millions of adults remain uninsured or underinsured. Compared with adults without barriers to health care, adults who lack health insurance coverage, have coverage gaps, or skip or delay care because of limited personal finances might face increased risk for poor physical and mental health and premature mortality. PERIOD COVERED: 2014...
February 24, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28231019/pro-inflammatory-cytokines-impair-vitamin-d-induced-host-defense-in-cultured-airway-epithelial-cells
#3
Jasmijn A Schrumpf, Gimano D Amatngalim, Joris B Veldkamp, Renate M Verhoosel, Dennis K Ninaber, Soledad R Ordonez, Anne M van der Does, Henk P Haagsman, Pieter S Hiemstra
Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37. Vitamin D deficiency is associated with chronic inflammatory lung diseases and respiratory infections. However, it is incompletely understood if and how (chronic) airway inflammation affects vitamin D metabolism and action. We hypothesized that long-term exposure of primary bronchial epithelial cells (PBEC) to pro-inflammatory cytokines alters their vitamin D metabolism, antibacterial activity and expression of hCAP18/LL-37...
February 23, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28230525/inference-and-forecast-of-h7n9-influenza-in-china-2013-to-2015
#4
Ruiyun Li, Yuqi Bai, Alex Heaney, Sasikiran Kandula, Jun Cai, Xuyi Zhao, Bing Xu, Jeffrey Shaman
The recent emergence of A(H7N9) avian influenza poses a significant challenge to public health in China and around the world; however, understanding of the transmission dynamics and progression of influenza A(H7N9) infection in domestic poultry, as well as spillover transmission to humans, remains limited. Here, we develop a mathematical model-Bayesian inference system which combines a simple epidemic model and data assimilation method, and use it in conjunction with data on observed human influenza A(H7N9) cases from 19 February 2013 to 19 September 2015 to estimate key epidemiological parameters and to forecast infection in both poultry and humans...
February 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28230524/early-2016-17-vaccine-effectiveness-estimates-against-influenza-a-h3n2-i-move-multicentre-case-control-studies-at-primary-care-and-hospital-levels-in-europe
#5
Esther Kissling, Marc Rondy
We measured early 2016/17 season influenza vaccine effectiveness (IVE) against influenza A(H3N2) in Europe using multicentre case control studies at primary care and hospital levels. IVE at primary care level was 44.1%, 46.9% and 23.4% among 0-14, 15-64 and ≥ 65 year-olds, and 25.7% in the influenza vaccination target group. At hospital level, IVE was 2.5%, 7.9% and 2.4% among ≥ 65, 65-79 and ≥ 80 year-olds. As in previous seasons, we observed suboptimal IVE against influenza A(H3N2).
February 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28230523/combined-effectiveness-of-prior-and-current-season-influenza-vaccination-in-northern-spain-2016-17-mid-season-analysis
#6
Jesús Castilla, Ana Navascués, Itziar Casado, Jorge Díaz-González, Alejandra Pérez-García, Leticia Fernandino, Iván Martínez-Baz, Aitziber Aguinaga, Francisco Pozo, Carmen Ezpeleta
The 2016/17 mid-season vaccine effectiveness estimate against influenza A(H3N2) was 15% (95% confidence interval: -11 to 35) in Navarre. Comparing to individuals unvaccinated in the current and four prior seasons, effectiveness was 24% for current and 3-4 prior doses, 61% for current and 1-2 prior doses, 42% for only current vaccination, and 58% for 3-4 prior doses. This suggests moderate effectiveness for different combinations of vaccination in the current and prior seasons.
February 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28230493/using-correlative-light-and-electron-microscopy-to-understand-influenza-a-viral-assembly
#7
Ana Laura Sousa, Sílvia Vale-Costa, Maria João Amorim, Erin M Tranfield
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230273/comparison-of-pathogen-eradication-rate-and-safety-of-anti-bacterial-agents-for-bronchitis-a-network-meta-analysis
#8
Jinghua Wang, Haiyang Xu, Dunwei Wang, Mingxian Li
OBJECTIVE: A large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. Although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. We are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28229066/a-case-of-influenza-a-h3n2-complicated-by-community-acquired-pneumonia-and-death-in-a-young-healthy-adult-during-the-2013-2014-season
#9
Lauren F Collins, Benjamin D Anderson, Gregory C Gray
With multiple available vaccines and antivirals, seasonal influenza A is typically a self-limited acutely debilitating illness in young healthy adults. Here, we illustrate unexpected morbidity and mortality in a relatively young and healthy patient seen at a large tertiary care academic medical center for seasonal influenza A (H3N2) complicated by community-acquired pneumonia, hypoxic respiratory failure, septic shock, and death.
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28228559/targeting-influenza-virus-hemagglutinin-to-xcr1-dendritic-cells-in-the-absence-of-receptor-mediated-endocytosis-enhances-protective-antibody-responses
#10
Arnar Gudjonsson, Anna Lysén, Sreekumar Balan, Vibeke Sundvold-Gjerstad, Catharina Arnold-Schrauf, Lisa Richter, Espen S Bækkevold, Marc Dalod, Bjarne Bogen, Even Fossum
Targeting Ags to conventional dendritic cells can enhance Ag-specific immune responses. Although most studies have focused on the induction of T cell responses, the mechanisms by which targeting improves Ab responses are poorly understood. In this study we present data on the use of human XCL1 (hXCL1) and hXCL2 fusion vaccines in a murine model. We show that the human chemokines bound type 1 conventional dendritic cells (cDC1), and that immunization with influenza virus hemagglutinin fused to hXCL1 or hXCL2 induced full protection against influenza challenge...
February 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28228302/influenza-vaccination-in-north-indian-patients-with-heart-failure
#11
Parvaiz A Koul, Saima Ali, Hyder Mir, Syed J Ahmad, Shabir Akram Bhat, Muneer A Bhat
BACKGROUND: No data exists regarding the uptake of influenza vaccination in patients with heart failure (HF) in India. The present study was designed to assess the uptake, knowledge, attitude and practices of the Indian HF patients towards influenza vaccination. METHODS AND RESULTS: Five-hundred patients with acute/chronic HF were approached for a personal interview and responses to an interview recorded in a pre-defined questionnaire depicting their knowledge, attitudes and practice regarding influenza vaccination...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228112/three-case-reports-of-post-immunization-and-post-viral-bullous-pemphigoid-looking-for-the-right-trigger
#12
Luca Baroero, Paola Coppo, Laura Bertolino, Stefano Maccario, Francesco Savino
BACKGROUND: Bullous pemphigoid (BP) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. CASE PRESENTATION: Here we describe three cases of BP which were referred to our department in the last 15 years. Two of them developed an eruption of bullous lesions just a few days after vaccination for diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B and Haemophilus influenzae B. The third patient developed the same blistering lesions shortly after herpetic stomatitis...
February 23, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28225904/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#13
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28225898/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#14
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
February 16, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28224774/comparison-of-luminex-nxtag-respiratory-pathogen-panel-and-xtag-respiratory-viral-panel-fast-version-2-for-the-detection-of-respiratory-viruses
#15
Chun Kiat Lee, Hong Kai Lee, Christopher Wei Siong Ng, Lily Chiu, Julian Wei Tze Tang, Tze Ping Loh, Evelyn Siew Chuan Koay
Owing to advancements in molecular diagnostics, recent years have seen an increasing number of laboratories adopting respiratory viral panels to detect respiratory pathogens. In December 2015, the NxTAG respiratory pathogen panel (NxTAG RPP) was approved by the United States Food and Drug Administration. We compared the clinical performance of this new assay with that of the xTAG respiratory viral panel (xTAG RVP) FAST v2 using 142 clinical samples and 12 external quality assessment samples. Discordant results were resolved by using a laboratory-developed respiratory viral panel...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28224114/ha-triggers-the-switch-from-mek1-sumoylation-to-phosphorylation-of-the-erk-pathway-in-influenza-a-virus-infected-cells-and-facilitates-its-infection
#16
Chengmin Wang, Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao, Shelan Liu, Li Xie, Yaxiong Jia, Hua Ding, Xiufeng Wan, Hongxuan He
Several post-translational modifications in host cells are hijacked by pathogens to facilitate their propagation. A number of components of the influenza virus have been reported to be modified by small ubiquitin-like modifier (SUMO) proteins during infection. We hypothesized that the MAPK/ERK pathway could be modified by SUMO1 because the SUMOylation of MEK1 was quickly eliminated after influenza A virus infection. We identified host cell MEK1 as a target of SUMO1 through LC/MS/MS, and enhanced MEK1 SUMOylation inhibited the infection of the virus, while inhibition of host cell MEK1 SUMOylation facilitated virus propagation...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28223865/knowledge-attitudes-beliefs-and-barriers-associated-with-the-uptake-of-influenza-vaccine-among-pregnant-women
#17
Ahmed Y Mayet, Ghadeer K Al-Shaikh, Hazem M Al-Mandeel, Nada A Alsaleh, Amani F Hamad
Objective: The purpose of the study was to assess the knowledge, attitudes, beliefs, and factors associated with the uptake of the influenza (flu) vaccination in women within Saudi Arabia during their pregnancy period. Methods: A cross-sectional prospective survey was conducted on 1085 pregnant women at the antenatal clinic over a period of 6 weeks with the provision of influenza vaccination. The questionnaire collected demographic and other data; it included 12 questions on their general knowledge and assessed their attitude toward influenza vaccination, and their awareness of vaccine risk and the potential benefits during pregnancy...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28223682/environmental-surfaces-used-in-entry-day-corralling-likely-contribute-to-the-spread-of-influenza-a-virus-in-swine-at-agricultural-fairs
#18
Sarah E Lauterbach, Michele M Zentkovich, Sarah W Nelson, Jacqueline M Nolting, Andrew S Bowman
No abstract text is available yet for this article.
February 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28223680/uncomplicated-cystitis-in-an-adult-male-following-influenza-b-virus-infection
#19
Robert J Allen, Marios Koutsakos, Aeron C Hurt, Katherine Kedzierska
BACKGROUND Influenza B viruses cause seasonal epidemics of respiratory illness, circulating concurrently with influenza A viruses. However, virological and clinical knowledge of influenza B viruses is less well advanced than for influenza A, and in particular, complications associated with influenza B infection are not as commonly reported. Complications of influenza B infection predominantly include neurological and musculoskeletal pathologies, while a review of the literature shows that bacterial infections associated with influenza B viruses often involve Gram-positive organisms, with a smaller subset featuring Gram-negative species...
February 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28223386/surveillance-of-omadacycline-activity-tested-against-clinical-isolates-from-a-global-north-america-europe-latin-america-and-asia-western-pacific-collection-2010-2011
#20
Michael A Pfaller, Michael D Huband, Paul R Rhomberg, Robert K Flamm
Omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. In this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in Asia-Pacific (11,397 isolates), Europe (23,490 isolates), Latin America (8,038 isolates) and North America (26,321 isolates)...
February 21, 2017: Antimicrobial Agents and Chemotherapy
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