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https://www.readbyqxmd.com/read/29353059/ask-family-kinases-are-required-for-optimal-nlrp3-inflammasome-priming
#1
David E Place, Parimal Samir, Rajendra Karki, Benoit Briard, Peter Vogel, Thirumala-Devi Kanneganti
Activation of the multimeric inflammasome complex leads to inflammatory responses to biotic and abiotic triggers. The inflammasome sensor, Nod-like receptor family Pyrin domain containing 3 (NLRP3), is activated by a range of stimuli and is tightly regulated to restrict excessive inflammation. Because NLRP3 responds broadly to cellular insults and regulates cell death similar to the stress-activated apoptosis signal-regulating kinases 1 and 2 (ASK1/2), we hypothesized that ASK1/2 may regulate NLRP3 activity...
January 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29352897/cost-utility-of-quadrivalent-versus-trivalent-influenza-vaccine-in-brazil-comparison-of-outcomes-from-different-static-model-types
#2
Laure-Anne Van Bellinghen, Alen Marijam, Gabriela Tannus Araujo, Jorge Gomez, Ilse Van Vlaenderen
BACKGROUND: Influenza burden in Brazil is considerable with 4.2-6.4 million cases in 2008 and influenza-like-illness responsible for 16.9% of hospitalizations. Cost-effectiveness of influenza vaccination may be assessed by different types of models, with limitations due to data availability, assumptions, and modelling approach. OBJECTIVE: To understand the impact of model complexity, the cost-utility of quadrivalent versus trivalent influenza vaccines (QIV versus TIV) in Brazil was estimated using three distinct models: a 1-year decision tree population model with three age groups (FLOU); a more detailed 1-year population model with five age groups (FLORA); and a more complex lifetime multi-cohort Markov model with nine age groups (FLORENCE)...
January 17, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29352811/single-nucleotide-polymorphisms-in-genes-encoding-penicillin-binding-proteins-in-%C3%AE-lactamase-negative-ampicillin-resistant-haemophilus-influenzae-in-japan
#3
Kazuhisa Misawa, Norihito Tarumoto, Shinsuke Tamura, Morichika Osa, Takaaki Hamamoto, Atsushi Yuki, Yuji Kouzaki, Kazuo Imai, Runtuwene Lucky Ronald, Toshiyuki Yamaguchi, Takashi Murakami, Shigefumi Maesaki, Yutaka Suzuki, Akihiko Kawana, Takuya Maeda
OBJECTIVE: β-Lactamase-negative ampicillin-resistant Haemophilus influenzae is a common opportunistic pathogen of hospital- and community-acquired infections, harboring multiple single nucleotide polymorphisms in the ftsI gene, which codes for penicillin-binding protein-3. The objectives of this study were to perform comprehensive genetic analyses of whole regions of the penicillin-binding proteins in H. influenzae and to identify additional single nucleotide polymorphisms related to antibiotic resistance, especially to ampicillin and other cephalosporins...
January 20, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29352631/we-could-learn-much-more-from-1918-pandemic-the-mis-fortune-of-research-relying-on-original-death-certificates
#4
Wladimir J Alonso, Francielle C Nascimento, Gerardo Chowell, Cynthia Schuck-Paim
PURPOSE: The analysis of historical death certificates has enormous potential for understanding how the health of populations was shaped by diseases and epidemics and by the implementation of specific interventions. In Brazil, the systematic archiving of mortality records was initiated only in 1944-hence the analysis of death registers before this time requires searching for these documents in public archives, notaries, parishes, and especially ancient cemeteries, which are often the only remaining source of information about these deaths...
January 9, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29352371/innate-and-adaptive-t-cells-in-influenza-disease
#5
REVIEW
Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H O Nguyen, Katherine Kedzierska
Influenza is a major global health problem, causing infections of the respiratory tract, often leading to acute pneumonia, life-threatening complications and even deaths. Over the last seven decades, vaccination strategies have been utilized to protect people from complications of influenza, especially groups at high risk of severe disease. While current vaccination regimens elicit strain-specific antibody responses, they fail to generate cross-protection against seasonal, pandemic and avian viruses. Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized...
January 20, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29352288/phospholipid-scramblase-1-interacts-with-influenza-a-virus-np-impairing-its-nuclear-import-and-thereby-suppressing-virus-replication
#6
Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP). As a major component of the vRNP complex, the viral nucleoprotein (NP) mediates the nuclear import of the vRNP complex via its nuclear localization signals (NLSs). Clearly, an effective way for the host to antagonize IAV infection would be by targeting vRNP nuclear import. Here, we identified phospholipid scramblase 1 (PLSCR1) as a binding partner of NP by using a yeast two-hybrid (Y2H) screen...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29352186/glycolysis-promotes-caspase-3-activation-in-lipid-rafts-in-t-cells
#7
Michael A Secinaro, Karen A Fortner, Oliver Dienz, Angela Logan, Michael P Murphy, Vikas Anathy, Jonathan E Boyson, Ralph C Budd
Resting T cells undergo a rapid metabolic shift to glycolysis upon activation in the presence of interleukin (IL)-2, in contrast to oxidative mitochondrial respiration with IL-15. Paralleling these different metabolic states are striking differences in susceptibility to restimulation-induced cell death (RICD); glycolytic effector T cells are highly sensitive to RICD, whereas non-glycolytic T cells are resistant. It is unclear whether the metabolic state of a T cell is linked to its susceptibility to RICD. Our findings reveal that IL-2-driven glycolysis promotes caspase-3 activity and increases sensitivity to RICD...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29352168/epigenetic-control-of-influenza-virus-role-of-h3k79-methylation-in-interferon-induced-antiviral-response
#8
Laura Marcos-Villar, Juan Díaz-Colunga, Juan Sandoval, Noelia Zamarreño, Sara Landeras-Bueno, Manel Esteller, Ana Falcón, Amelia Nieto
Influenza virus stablishes a network of virus-host functional interactions, which depends on chromatin dynamic and therefore on epigenetic modifications. Using an unbiased search, we analyzed the epigenetic changes at DNA methylation and post-translational histone modification levels induced by the infection. DNA methylation was unaltered, while we found a general decrease on histone acetylation, which correlates with transcriptional inactivation and may cooperate with the impairment of cellular transcription that causes influenza virus infection...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351447/cigarette-smoke-dampens-anti-viral-signaling-in-small-airway-epithelial-cells-by-disrupting-tlr3-cleavage
#9
Parker F Duffney, Claire E McCarthy, Aitor Nogales, Thomas H Thatcher, Luis Martinez-Sobrido, Richard P Phipps, Patricia J Sime
Cigarette smokers and people exposed to secondhand smoke are at an increased risk for pulmonary viral infections, yet the mechanism responsible for this heightened susceptibility is not understood. To understand the effect of cigarette smoke on susceptibility to viral infection we used an air-liquid interface culture system, and exposed primary human small airway epithelial cells (SAEC) to whole cigarette smoke followed by treatment with the viral mimetic polyinosinic polycytidylic acid (poly I:C) or influenza A virus (IAV)...
December 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29351330/use-of-influenza-antivirals-in-patients-hospitalized-in-hong-kong-2000-2015
#10
Benjamin J Cowling, Celine S L Chui, Wey Wen Lim, Peng Wu, Christopher K M Hui, J S Malik Peiris, Esther W Chan
OBJECTIVES: We aimed to describe patterns in the usage of antivirals to treat influenza virus infection in hospitals in Hong Kong from 2000 through 2015. METHODS: We analyzed centralized electronic health records that included dispensation information and diagnosis codes. Information collected on admissions included patient age, sex, admission year and month, and medications dispensed, and were matched with the first 15 discharge diagnosis codes. We divided monthly admission episodes by relevant population denominators to obtain admission rates, and stratified analyses by drug type, age group, and diagnosis codes...
2018: PloS One
https://www.readbyqxmd.com/read/29350887/species-specific-clinical-characteristics-of-human-coronavirus-infection-among-otherwise-healthy-adolescents-and-adults
#11
Monique Bouvier, Wei-Ju Chen, John C Arnold, Mary P Fairchok, Patrick J Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H Burgess, Eugene V Millar
Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multi-site, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350841/epidemiology-and-molecular-characterization-of-influenza-viruses-in-burkina-faso-sub-saharan-africa
#12
Armel M Sanou, Sampoko Carine M Wandaogo, Armel Poda, Laure Tamini, Anselme E Kyere, Tani Sagna, Macaire S Ouedraogo, Maude Pauly, Judith M Hübschen, Claude P Muller, Zekiba Tarnagda, Chantal J Snoeck
BACKGROUND: The importance of influenza viruses in respiratory infections in sub-Saharan Africa has been historically overlooked, including in Burkina Faso. This study therefore aimed at evaluating the prevalence and seasonal occurrence of influenza viruses in children under five years old, at risk of influenza-related complications, presenting with influenza-like illness (ILI) or severe acute respiratory infection (SARI). The study also aimed at identifying the periods with increased influenza transmission for vaccination recommendations in Burkina Faso...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350791/comparison-of-outpatient-medically-attended-and-community-level-influenza-like-illness-new-york-city-2013-2015
#13
Kate E Russell, Ashley Fowlkes, Melissa S Stockwell, Celibell Y Vargas, Lisa Saiman, Elaine L Larson, Philip LaRussa, Steve Di Lonardo, Michael Popowich, Kirsten St George, Andrea Steffens, Carrie Reed
BACKGROUND: Surveillance of influenza-like illness (ILI) in the United States is primarily conducted through medical settings despite a significant burden of non-medically attended ILI. OBJECTIVES: To assess consistency between surveillance for respiratory viruses in outpatient and community settings using ILI surveillance from the Centers for Disease Control and Prevention Influenza Incidence Surveillance Project (IISP) and the Mobile Surveillance for Acute Respiratory Infections (ARI) and Influenza-Like Illness in the Community (MoSAIC) Study...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350169/containment-of-highly-pathogenic-avian-influenza-a-h5n1-virus-lebanon-20161
#14
Zeina E Farah, Omaya Khatib, Sahar Hamadeh, Khadija Ahmad, Bassel El Bazzal, Pierre Zalloua, Walid Ammar, Nada Ghosn
A preparedness plan for avian influenza A(H5N1) virus infection was activated in Lebanon in 2016 after reported cases in poultry. Exposed persons were given prophylaxis and monitored daily. A total of 185 exposed persons were identified: 180 received prophylaxis, 181 were monitored, and 41 suspected cases were reported. All collected specimens were negative for virus by PCR.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350143/adenovirus-type-4-respiratory-infections-among-civilian-adults-northeastern-united-states-2011-20151
#15
Adriana E Kajon, Daryl M Lamson, Camden R Bair, Xiaoyan Lu, Marie L Landry, Marilyn Menegus, Dean D Erdman, Kirsten St George
Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350140/co-circulation-of-influenza-a-h5-h7-and-h9-viruses-and-co-infected-poultry-in-live-bird-markets-cambodia
#16
Paul F Horwood, Srey Viseth Horm, Annika Suttie, Sopheak Thet, Phalla Y, Sareth Rith, San Sorn, Davun Holl, Sothyra Tum, Sowath Ly, Erik A Karlsson, Arnaud Tarantola, Philippe Dussart
Longitudinal surveillance of 2 live bird markets in Cambodia revealed year-round, high co-circulation of H5, H7, and H9 influenza viruses. We detected influenza A viruses in 51.3% of ducks and 39.6% of chickens, and co-infections, mainly by H5 and H9 viruses, in 0.8% of ducks and 4.5% of chickens.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350071/disclosing-respiratory-coinfections-a-broad-range-panel-assay-for-avian-respiratory-pathogens-on-a-nanofluidic-pcr-platform
#17
Guillaume Croville, Charlotte Foret, Pauline Heuillard, Alexis Senet, Mattias Delpont, Mohammed Mouahid, Mariette F Ducatez, Faouzi Kichou, Jean-Luc Guerin
Respiratory syndromes (RS) are among the most significant pathological conditions in food animals and are caused by complex coactions of pathogens and environmental factors. In poultry, low pathogenic avian Influenza A viruses, metapneumoviruses, infectious bronchitis virus, infectious laryngotracheitis virus, Mycoplasma spp. Escherichia coli and/or Ornithobacterium rhinotracheale (ORT) in turkeys, are considered as key co-infectious agents of respiratory syndromes. Aspergillus sp., Pasteurella multocida, Avibacterium paragallinarum or Chlamydia psittaci may also be involved in respiratory outbreaks...
January 19, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29349940/etiology-of-invasive-bacterial-infections-in-immunocompetent-children-in-korea-2006-2010-a-retrospective-multicenter-study
#18
Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo Kim, Su Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349270/breaking-down-the-monolith-understanding-flu-vaccine-uptake-among-african-americans
#19
Sandra Crouse Quinn, Amelia Jamison, Ji An, Vicki S Freimuth, Gregory R Hancock, Donald Musa
Black adults are significantly less likely to be immunized for seasonal influenza when compared to Whites. This persistent disparity contributes to increased influenza-related morbidity and mortality in the African American population. Most scholarship on vaccine disparities has compared Whites and Blacks. Employing Public Health Critical Race Praxis, this study seeks to shift the focus to explore differences within the Black population. Utilizing a nationally-representative 2015 survey of US Black adults (n = 806), we explore differences by gender, age, income, and education across vaccine-related measures (e...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29349092/cathepsin-b-plays-a-key-role-in-optimal-production-of-the-influenza-a-virus
#20
Macon D Coleman, Soon-Duck Ha, S M Mansour Haeryfar, Stephen Dominic Barr, Sung Ouk Kim
Background: Influenza A virus (IAV) is the etiologic agent of the febrile respiratory illness, commonly referred to as 'flu'. The lysosomal protease cathepsin B (CTSB) has shown to be involved in the lifecycle of various viruses. Here, we examined the role of CTSB in the IAV lifecycle. Methods: CTSB-deficient (CTSB-/-) macrophages and the human lung epithelial cell line A549 cells treated with CA-074Me were infected with the A/Puerto Rico/8/34 strain of IAV (IAV-PR8)...
2018: Journal of Virology & Antiviral Research
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