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https://www.readbyqxmd.com/read/29752897/ajo-centennial-the-influence-of-early-ophthalmic-hospitals-on-the-journal
#1
Akhilesh S Pathipati, James C Tsai
PURPOSE: To consider the American Journal of Ophthalmology's role as not only a forum to describe clinical and scientific advances but also as a record of institutional histories. We used the New York Eye and Ear Infirmary of Mount Sinai, the Massachusetts Eye and Ear Infirmary, and the Wills Eye Hospital as case studies on the journal's role in documenting the people and organizations that have moved ophthalmology forward. DESIGN: Perspective METHODS: Using the ScienceDirect database, we conducted a literature search to gather all mentions of the three eye hospitals in the journal's archives from 1918 to 2018...
May 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29751992/the-impact-of-health-insurance-status-on-the-stage-of-cervical-cancer-diagnosis-at-a-tertiary-care-center-in-massachusetts
#2
Michelle Davis, Kyle Strickland, Sarah Rae Easter, Michael Worley, Colleen Feltmate, Michael Muto, Neil Horowitz, Ross Berkowitz, Sarah Feldman
OBJECTIVE: To evaluate the impact of insurance status on the stage of cervical cancer diagnosed and treated at a tertiary care center in Massachusetts and review the preceding screening history. METHODS: An IRB approved retrospective cohort study was conducted of patients with a diagnosis of cervical cancer treated at Brigham and Women's Hospital (BWH) between January 2011 and June 2016. Clinical and demographic data was extracted from the longitudinal medical record...
May 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29696750/angelman-syndrome-in-adolescence-and-adulthood-a-retrospective-chart-review-of-53-cases
#3
Ankita Prasad, Olivia Grocott, Kimberly Parkin, Anna Larson, Ronald L Thibert
Angelman syndrome is a neurogenetic disorder with varying clinical presentations and symptoms as the individual ages. The goal of this study was to characterize changes over time in the natural history of this syndrome in a large population. We reviewed the medical records of the 53 patients who were born prior to 2000 and seen at the Angelman Syndrome Clinic at Massachusetts General Hospital to assess neurological, sleep, behavioral, gastrointestinal, orthopedic, and ophthalmologic functioning. The average age of this cohort was 24 years...
April 25, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29622625/lipid-lowering-agents-and-high-hdl-high-density-lipoprotein-are-inversely-associated-with-intracranial-aneurysm-rupture
#4
Anil Can, Victor M Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
BACKGROUND AND PURPOSE: Growing evidence from experimental animal models and clinical studies suggests the protective effect of statin use against rupture of intracranial aneurysms; however, results from large studies detailing the relationship between intracranial aneurysm rupture and total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and lipid-lowering agent use are lacking. METHODS: The medical records of 4701 patients with 6411 intracranial aneurysms diagnosed at the Massachusetts General Hospital and the Brigham and Women's Hospital between 1990 and 2016 were reviewed and analyzed...
April 5, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29576042/a-generalizable-data-driven-approach-to-predict-daily-risk-of-clostridium-difficile-infection-at-two-large-academic-health-centers
#5
Jeeheh Oh, Maggie Makar, Christopher Fusco, Robert McCaffrey, Krishna Rao, Erin E Ryan, Laraine Washer, Lauren R West, Vincent B Young, John Guttag, David C Hooper, Erica S Shenoy, Jenna Wiens
OBJECTIVE An estimated 293,300 healthcare-associated cases of Clostridium difficile infection (CDI) occur annually in the United States. To date, research has focused on developing risk prediction models for CDI that work well across institutions. However, this one-size-fits-all approach ignores important hospital-specific factors. We focus on a generalizable method for building facility-specific models. We demonstrate the applicability of the approach using electronic health records (EHR) from the University of Michigan Hospitals (UM) and the Massachusetts General Hospital (MGH)...
April 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29565711/cancer-among-adolescents-and-young-adults-in-massachusetts-from-2004-to-2014
#6
Erin E Cook, Annie MacMillan, Susan T Gershman
This brief report describes the burden of cancer among adolescents and young adults (AYAs), aged 15-39 years, in Massachusetts from 2004 to 2014 using data from the Massachusetts Cancer Registry and Registry of Vital Records and Statistics. In Massachusetts, 4.6% of cancer cases and 1.3% of cancer deaths occurred among AYAs. The incidence rate of cancer among AYAs was 77.6 cases per 100,000 and the mortality rate was 8.0 deaths per 100,000. The incidence rates of melanoma and Hodgkin lymphoma have been decreasing annually...
March 22, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29497883/trends-of-two-hpv-associated-cancers-in-massachusetts-cervical-and-oropharyngeal-cancer
#7
Erin E Cook, Susan T Gershman, Jane J Kim, Rulla M Tamimi, R Monina Klevens, Michelle D Holmes
PURPOSE: To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts. METHODS: From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U...
May 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29482205/association-of-coprescription-of-triptan-antimigraine-drugs-and-selective-serotonin-reuptake-inhibitor-or-selective-norepinephrine-reuptake-inhibitor-antidepressants-with-serotonin-syndrome
#8
Yulia Orlova, Paul Rizzoli, Elizabeth Loder
Importance: In 2006, the US Food and Drug Administration (FDA) issued an advisory warning on the risk of serotonin syndrome with concomitant use of triptans and selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI) antidepressants, but the true risk of serotonin syndrome in these patients remains unknown. Objective: To assess the risk of serotonin syndrome with concomitant use of triptans and SSRI or SNRI antidepressants...
February 26, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29450453/the-association-of-age-with-clinical-presentation-and-comorbidities-of-pyoderma-gangrenosum
#9
Hovik J Ashchyan, Daniel C Butler, Caroline A Nelson, Megan H Noe, William G Tsiaras, Stephen J Lockwood, William D James, Robert G Micheletti, Misha Rosenbach, Arash Mostaghimi
Importance: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies. Objective: To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. Design, Setting, and Participants: This was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings...
April 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29333911/the-challenge-of-pediatric-uveitis-tertiary-referral-center-experience-in-the-united-states
#10
Mariantonia Ferrara, Laura Eggenschwiler, Andrew Stephenson, Alyssa Montieth, Nakhoul Nakhoul, Rafael Araùjo-Miranda, C Stephen Foster
PURPOSE: To describe the distribution, clinical findings, visual outcomes, treatment, and complications of children with uveitis at a tertiary referral ophthalmic center. METHODS: Retrospective cohort study. We reviewed the medical records of all patients ≤16 years with uveitis referred to Massachusetts Eye Research and Surgery Institution from March 2005 to July 2016. RESULTS: Of 286 included children, 62.24% were female. Mean age of onset was 8...
January 15, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29238798/association-between-hypercoagulable-conditions-and-calciphylaxis-in-patients-with-renal-disease-a-case-control-study
#11
Allison S Dobry, Lauren N Ko, Jessica St John, J Mark Sloan, Sagar Nigwekar, Daniela Kroshinsky
Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis. Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD...
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29195030/accuracy-of-birth-certificate-head-circumference-measurements-massachusetts-2012-2013
#12
Nicholas J Somerville, Xiaoli Chen, Dominique Heinke, Sarah L Stone, Cathleen Higgins, Susan E Manning, Sharon Pagnano, Mahsa M Yazdy, Marlene Anderka
BACKGROUND: Zika virus has recently emerged as a novel cause of microcephaly. CDC has asked states to rapidly ascertain and report cases of Zika-linked birth defects, including microcephaly. Massachusetts added head circumference to its birth certificate (BC) in 2011. The accuracy of head circumference measurements from state vital records data has not been reported. METHODS: We sought to assess the accuracy of Massachusetts BC head circumference measurements by comparing them to measurements for 2,217 infants born during 2012-2013 captured in the Massachusetts Birth Defects Monitoring Program (BDMP) data system...
March 15, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29120717/cataract-surgery-after-proton-beam-irradiation-for-uveal-tumors
#13
Zeba A Syed, Roberto Pineda
PURPOSE: To study the risks associated with cataract surgery in patients with previous proton-beam irradiation (PBI), focusing on preoperative risk factors, intraoperative findings, and postoperative complications. SETTING: Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA. DESIGN: Retrospective case series. METHODS: Electronic medical records of patients who had PBI and cataract surgery between January 1, 2006, and October 1, 2016, were reviewed...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28971925/outcomes-in-two-massachusetts-hospital-systems-give-reason-for-optimism-about-communication-and-resolution-programs
#14
Michelle M Mello, Allen Kachalia, Stephanie Roche, Melinda Van Niel, Lisa Buchsbaum, Suzanne Dodson, Patricia Folcarelli, Evan M Benjamin, Kenneth E Sands
Through communication-and-resolution programs, hospitals and liability insurers communicate with patients when adverse events occur; investigate and explain what happened; and, where appropriate, apologize and proactively offer compensation. Using data recorded by program staff members and from surveys of involved clinicians, we examined case outcomes of a program used by two academic medical centers and two of their community hospitals in Massachusetts in the period 2013-15. The hospitals demonstrated good adherence to the program protocol...
October 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28797530/factors-affecting-voice-therapy-completion-in-singers
#15
Michelle Adessa, Tara Stadelman-Cohen, Lauryn Zipse, A J Guarino, James T Heaton
OBJECTIVE: The purpose of this study was to determine (a) which factors may affect singers' completing voice therapy, and (b) develop predictive profiles to capture those singers at risk for dropping out of voice therapy. STUDY DESIGN: A case-control study was conducted comparing singers who completed voice therapy to singers who dropped out of voice therapy. METHODS: Six factors, including age, gender, diagnosis, length of time between laryngology referral and commencement of therapy, type of singer, and referral source were investigated in relation to voice therapy completion using the medical records of 409 singers in the Massachusetts General Hospital Voice Center database...
August 7, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28752411/alcohol-consumption-and-aneurysmal-subarachnoid-hemorrhage
#16
Anil Can, Victor M Castro, Yildirim H Ozdemir, Sarajune Dagen, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
Alcohol consumption may be a modifiable risk factor for rupture of intracranial aneurysms. Our aim is to evaluate the association between ruptured aneurysms and alcohol consumption, intensity, and cessation. The medical records of 4701 patients with 6411 radiographically confirmed intracranial aneurysms diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed. Individuals were divided into cases with ruptured aneurysms and controls with unruptured aneurysms...
February 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/28648912/minor-salivary-gland-biopsy-an-important-contributor-to-the-diagnosis-of-sj%C3%A3-gren-syndrome
#17
Sarah Wicheta, Troy Van der Groen, William C Faquin, Meredith August
PURPOSE: Sjögren syndrome (SS), although commonly associated with xerostomia and xerophthalmia, can present with extraglandular manifestations that make definitive diagnosis difficult. The 2 leading diagnostic classification systems include a positive minor salivary gland biopsy (MSGB) result as a major inclusion criterion. The purpose of this study was to better define the role of the MSGB in establishing a diagnosis of SS in a cohort of referred patients. MATERIALS AND METHODS: This is a retrospective cohort study of patients referred to the Massachusetts General Hospital Department of Oral and Maxillofacial Surgery (Boston, MA) over a 5-year period to establish a diagnosis of SS...
December 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28253231/baseline-prevalence-of-birth-defects-associated-with-congenital-zika-virus-infection-massachusetts-north-carolina-and-atlanta-georgia-2013-2014
#18
Janet D Cragan, Cara T Mai, Emily E Petersen, Rebecca F Liberman, Nina E Forestieri, Alissa C Stevens, Augustina Delaney, April L Dawson, Sascha R Ellington, Carrie K Shapiro-Mendoza, Julie E Dunn, Cathleen A Higgins, Robert E Meyer, Tonya Williams, Kara N D Polen, Kim Newsome, Megan Reynolds, Jennifer Isenburg, Suzanne M Gilboa, Dana M Meaney-Delman, Cynthia A Moore, Coleen A Boyle, Margaret A Honein
Zika virus infection during pregnancy can cause serious brain abnormalities, but the full range of adverse outcomes is unknown (1). To better understand the impact of birth defects resulting from Zika virus infection, the CDC surveillance case definition established in 2016 for birth defects potentially related to Zika virus infection* (2) was retrospectively applied to population-based birth defects surveillance data collected during 2013-2014 in three areas before the introduction of Zika virus (the pre-Zika years) into the World Health Organization's Region of the Americas (Americas) (3)...
March 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28238953/cost-effectiveness-of-screening-patients-with-gastroesophageal-reflux-disease-for-barrett-s-esophagus-with-a-minimally-invasive-cell-sampling-device
#19
Curtis R Heberle, Amir-Houshang Omidvari, Ayman Ali, Sonja Kroep, Chung Yin Kong, John M Inadomi, Joel H Rubenstein, Angela C Tramontano, Emily C Dowling, William D Hazelton, E Georg Luebeck, Iris Lansdorp-Vogelaar, Chin Hur
BACKGROUND & AIMS: It is important to identify patients with Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with BE usually are identified by endoscopy, which is expensive. The Cytosponge, which collects tissue from the esophagus noninvasively, could be a cost-effective tool for screening individuals with gastroesophageal reflux disease (GERD) who are at increased risk for BE. We developed a model to analyze the cost effectiveness of using the Cytosponge in first-line screening of patients with GERD for BE with endoscopic confirmation, compared with endoscopy screening only...
September 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28214219/perpetuating-stigma-or-reducing-risk-perspectives-from-naloxone-consumers-and-pharmacists-on-pharmacy-based-naloxone-in-2-states
#20
Traci C Green, Patricia Case, Haley Fiske, Janette Baird, Shachan Cabral, Dina Burstein, Victoriana Schwartz, Nathan Potter, Alexander Y Walley, Jeffrey Bratberg
OBJECTIVES: Little is known about attitudes of pharmacists and consumers to pharmacy naloxone. We examined perceptions and experiences of pharmacy naloxone from people with opioid use disorder, patients taking chronic opioids for pain, caregivers of opioid users, and pharmacists from 2 early pharmacy naloxone adopter states: Massachusetts and Rhode Island. DESIGN: Eight focus groups (4 per state) were held in October to December 2015. SETTING AND PARTICIPANTS: Participants were recruited from pharmacies, health clinics, and community organizations; pharmacists were recruited from professional organizations and pharmacy colleges...
March 2017: Journal of the American Pharmacists Association: JAPhA
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