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https://www.readbyqxmd.com/read/27880044/tuberculosis-airway-obstruction-and-mortality-in-a-finnish-population
#1
Tiina Mattila, Markku Heliövaara, Harri Rissanen, Paul Knekt, Pauli Puukka, Tuula Vasankari
There is little long-term follow-up data concerning the association between past pulmonary tuberculosis (TB), airway obstruction and mortality. We aimed to analyse a national health examination survey data from 6701 adult Finns undergoing spirometry between 1978 and 1980 (follow-up through 2013). We identified TB either through a disease history or by a TB-indicative scar on a chest x-ray. We specified obstruction using the lower limit of normal (LLN) and classified severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-4...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/26885334/the-prevalence-of-pneumocystis-jirovecii-among-patients-with-different-chronic-pulmonary-disorders-in-ahvaz-iran
#2
Elham Aboualigalehdari, Ali Zarei Mahmoudabadi, Mahnaz Fatahinia, Esmaeil Idani
BACKGROUND AND OBJECTIVES: Pneumocystis jirovecii pneumonia (PJP) is a chronic fungal infection that caused by P. jirovecii. Disease is more prevalent among the HIV-infected patients. The colonization of pneumocystis in human respiratory system is associated with the airway inflammation and obstruction. The current study was conducted to identify the prevalence of P. jirovecii among the patients with chronic pulmonary disorders in Ahvaz, Iran. MATERIALS AND METHODS: In the present study, 115 bronchoalveolar lavage (BAL) specimens were collected from patients...
December 2015: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/26284920/multidrug-resistant-tuberculosis-in-patients-with-chronic-obstructive-pulmonary-disease-in-china
#3
Jiang-Nan Zhao, Xian-Xin Zhang, Xiao-Chun He, Guo-Ru Yang, Xiao-Qi Zhang, Wen-Gen Xin, Huai-Chen Li
BACKGROUND: Relatively little is known about the specific relationship and impact from chronic obstructive pulmonary disease (COPD) on multidrug-resistant tuberculsosis (MDR-TB). METHODS: We conducted a retrospective study included patients aged ≥40 years with a confirmed pulmonary TB at three tertiary hospitals (Shandong, China) between January 2011 and October 2014. Univariable and multivariable analyses were performed to identify the relationship of MDR-TB and COPD...
2015: PloS One
https://www.readbyqxmd.com/read/26221507/vitamin-d-status-and-distribution-in-patients-with-chronic-obstructive-pulmonary-disease-versus-healthy-controls
#4
Behzad Heidari, Yahya Javadian, Mahmoud Monadi, Yahya Dankob, Alireza Firouzjahi
BACKGROUND: Vitamin D has a potential to modulate inflammatory response against noxious particles in patients with chronic obstructive pulmonary disease (COPD). The present study was conducted to determine the status of serum vitamin D in COPD versus healthy group. METHODS: The patients presented to the outpatient pulmonary clinic of Ayatollah Rouhani Hospital, Babol Iran. Diagnosis of COPD was confirmed based on airflow limitation defined as FEV1/FVC ratio <70% and FEV1< 80% of predicted...
2015: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/25955625/hemoptysis-evaluation-and-management
#5
John Scott Earwood, Timothy Daniel Thompson
Hemoptysis is the expectoration of blood from the lung parenchyma or airways. The initial step in the evaluation is determining the origin of bleeding. Pseudohemoptysis is identified through the history and physical examination. In adults, acute respiratory tract infections (e.g., bronchitis, pneumonia), bronchiectasis, asthma, chronic obstructive pulmonary disease, and malignancy are the most common causes. Tuberculosis is a major cause of hemoptysis in endemic regions of the world. Although tuberculosis rates are low in the United States, they are increased in persons who are homeless or who were born in other countries; consideration for testing should be made on an individual basis...
February 15, 2015: American Family Physician
https://www.readbyqxmd.com/read/25914322/complicated-silicotuberculosis-in-a-south-african-gold-miner-a-case-report
#6
Tolu Oni, Rodney Ehrlich
We present a case of complicated silicotuberculosis in a former gold miner with a sufficiently heavy silica dust exposure to cause International Labor Organization grade 2/2 silicosis after a cumulative exposure duration of 11 years. We describe a cascade of complications-active pulmonary tuberculosis despite recent isoniazid prophylactic therapy, non-tuberculous mycobacterial disease, chronic airways obstruction, and spontaneous pneumothorax-and the difficulties, which arose, in diagnosis and management of such combined disease...
June 2015: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/25334853/hemoptysis-as-the-initial-presentation-of-broncholithiasis-a-case-report
#7
Bimaje Akpa, Jeffrey Shehane, Calvin Smith, Jason Martin
SESSION TITLE: Bronchology/Interventional Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: A broncholith is a calcified material in the bronchus. As a result of the relatively low incidence of this disease, broncholithiasis has often been neglected in the differential diagnosis of hemoptysis. As a result, patients have been wrongly tagged with more common diseases causing bronchial obstruction, thereby losing the benefit of prompt diagnosis and therapy...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25161190/dectin-1-is-expressed-in-human-lung-and-mediates-the-proinflammatory-immune-response-to-nontypeable-haemophilus-influenzae
#8
Kerstin A Heyl, Tilman E Klassert, Annina Heinrich, Mario M Müller, Esther Klaile, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B Singer, Hortense Slevogt
UNLABELLED: The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the respiratory tract. Therefore, we analyzed the expression pattern of Dectin-1 in the human lung. Immunohistochemically stained human lung sections from 17 out of 19 individuals were positive for Dectin-1, which was expressed mainly apically on bronchial and alveolar epithelium...
2014: MBio
https://www.readbyqxmd.com/read/25151366/fungal-culture-and-sensitisation-in-asthma-cystic-fibrosis-and-chronic-obstructive-pulmonary-disorder-what-does-it-tell-us
#9
REVIEW
Catherine H Pashley
Collectively asthma, chronic obstructive pulmonary disorder (COPD) and cystic fibrosis (CF) are very common, important causes of disease and ill health. Filamentous fungal colonisation of the airways can occur in all three disease groups, although the clinical relevance is unclear. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised severe complication of airway colonisation associated primarily with Aspergillus fumigatus. Fungal colonisation may have a deleterious effect without fulfilling all the diagnostic criteria of ABPA; however, a lack of standardisation in processing respiratory samples hampers comparisons...
December 2014: Mycopathologia
https://www.readbyqxmd.com/read/24902565/prevalence-of-aspergillus-sensitisation-in-pulmonary-tuberculosis-related-fibrocavitary-disease
#10
S Dhooria, P Kumar, B Saikia, A N Aggarwal, D Gupta, D Behera, A Chakrabarti, R Agarwal
SETTING: Aspergillus complicates the course of healed pulmonary tuberculosis (PTB), causing aspergilloma and chronic pulmonary aspergillosis. Whether Aspergillus also causes allergic sensitisation in PTB-related fibrocavitary disease and bronchiectasis remains unknown. OBJECTIVE: To investigate the prevalence of Aspergillus sensitisation in healed fibrocavitary PTB. DESIGN: In a case-control design, consecutive symptomatic new referrals with PTB-related fibrocavitary disease underwent spirometry, Aspergillus skin test and computed tomography of the chest, determination of serum IgE levels (total and Aspergillus fumigatus-specific), serum precipitins against A...
July 2014: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/24678708/nanocarriers-for-respiratory-diseases-treatment-recent-advances-and-current-challenges
#11
REVIEW
Adriana Trapani, Sante Di Gioia, Stefano Castellani, Annalucia Carbone, Gennara Cavallaro, Giuseppe Trapani, Massimo Conese
Pulmonary delivery of locally-acting drugs encapsulated in nanocarriers provides several advantages for the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary diseases, cystic fibrosis, tuberculosis and lung cancer. These advantages include, among others, sustained drug delivery to the lungs, reduced therapeutic dose and improved patient compliance. The aim of this review is to give an updated overview on recent advances recorded in the last few years in this field as well as on the major challenges still existing and that remain to be overcome before any clinical application...
2014: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/23910833/fatal-case-of-retropharyngeal-abscess-associated-with-pott-s-disease
#12
Basappa S Hugar, Y P Girish Chandra, P R Sreenivasa Babu, S H Jayanth, J Vinay
Retropharyngeal abscess is a rare, deep seated infection of the neck that usually affects young children. Chronic retropharyngeal abscess is rare and results from tuberculosis of the spine. Such swelling in the neck gradually increases in size and is detected during the routine radiological screening for symptoms like pain, dysphagia, fever, dyspnoea, progressive inspiratory stridor (from laryngeal obstruction), neck hyperextension etc, but rarely leads to sudden death due to airway obstruction. Thus the forensic pathologist rarely comes across such type of cases...
August 2013: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/23782483/the-challenge-of-chronic-lung-disease-in-hiv-infected-children-and-adolescents
#13
REVIEW
Heinrich C Weber, Robert P Gie, Mark F Cotton
Until recently, little attention has been given to chronic lung disease (CLD) in HIV-infected children. As the HIV epidemic matures in sub-Saharan Africa, adolescents who acquired HIV by vertical transmission are presenting to health services with chronic diseases. The most common is CLD, which is often debilitating. This review summarizes the limited data available on the epidemiology, pathophysiology, clinical picture, special investigations and management of CLD in HIV-infected adolescents. A number of associated conditions: lymphocytic interstitial pneumonitis, tuberculosis and bronchiectasis are well described...
2013: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/23631563/risk-factors-for-pulmonary-tuberculosis-in-patients-with-chronic-obstructive-airway-disease-in-taiwan-a-nationwide-cohort-study
#14
Chih-Hsin Lee, Ming-Chia Lee, Chin-Chung Shu, Chor-Shen Lim, Jann-Yuan Wang, Li-Na Lee, Kun-Mao Chao
BACKGROUND: An association between chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) has been described, mainly due to smoking and corticosteroid use. Whether inhaled corticosteroid (ICS) therapy is associated with an increased risk of TB remains unclear. METHODS: We selected COPD cases by using six diagnostic scenarios and control subjects from a nationwide health insurance database, and applied time-dependent Cox regression analysis to identify the risk factors for TB...
2013: BMC Infectious Diseases
https://www.readbyqxmd.com/read/23333920/synergy-of-il-27-and-tnf-%C3%AE-in-regulating-cxcl10-expression-in-lung-fibroblasts
#15
Shanshan Dong, Xuemei Zhang, Yujuan He, Fang Xu, Dairong Li, WenChun Xu, Hong Wang, Yibing Yin, Ju Cao
IL-27 is involved in inflammatory reactions. CXCL10 is an important chemokine contributing to airway inflammatory disease. In this study, we investigated whether IL-27 modulated the synthesis of CXCL10 in primary human lung fibroblasts (HLFs). HLFs were activated by IL-27 alone, or in combination with other cytokines. CXCL10 synthesis was measured by real-time PCR and ELISA. An examination of transcriptional regulation was performed via the transient transfection of promoter constructs, whereas mRNA stability was assessed by actinomycin D chase and real-time PCR...
April 2013: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/23333101/clinical-significance-of-pneumocystis-jiroveci-in-patients-with-active-tuberculosis
#16
Kelvin K W To, Ivan F N Hung, Ting Xu, Rosana W S Poon, Whitney C T Ip, Patrick T W Li, Clara P Y Li, Susanna K P Lau, Wing-Cheong Yam, Kwok-Hung Chan, Kwok-Yung Yuen
Pneumocystis colonization has been associated with airway inflammation and obstruction. We conducted a retrospective cohort study to investigate the clinical significance of Pneumocystis in the airway of patients with active tuberculosis. Of the 108 respiratory specimens tested positive for M. tuberculosis by polymerase chain reaction (PCR), 11 (10.2%) were also positive for Pneumocystis by PCR. Compared with patients tested negative for Pneumocystis, those with Pneumocystis had a higher serum alanine transaminase level, a greater likelihood of requiring oxygen supplementation, and a worse 30-day mortality...
March 2013: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/23285237/airway-epithelial-nf-%C3%AE%C2%BAb-activation-promotes-mycoplasma-pneumoniae-clearance-in-mice
#17
Di Jiang, Mark L Nelson, Fabienne Gally, Sean Smith, Qun Wu, Maisha Minor, Stephanie Case, Jyoti Thaikoottathil, Hong Wei Chu
BACKGROUND/OBJECTIVE: Respiratory infections including atypical bacteria Mycoplasma pneumoniae (Mp) contribute to the pathobiology of asthma and chronic obstructive pulmonary disease (COPD). Mp infection mainly targets airway epithelium and activates various signaling pathways such as nuclear factor κB (NF-κB). We have shown that short palate, lung, and nasal epithelium clone 1 (SPLUNC1) serves as a novel host defense protein and is up-regulated upon Mp infection through NF-κB activation in cultured human and mouse primary airway epithelial cells...
2012: PloS One
https://www.readbyqxmd.com/read/23029844/evaluation-of-respiratory-manifestations-in-systemic-lupus-erythematosus-with-special-reference-to-pulmonary-interstitial-involvement
#18
Asutosh Ghosh, Tapas Das, Alokendu Ghosh, Parthasarathi Karmakar, Jyotirmoy Pal
Different respiratory manifestations in systemic lupus erythematosus (SLE) are not uncommon. We lack sufficient Indian data in this regard. Forty diagnosed cases of SLE were evaluated, to find out the prevalence of respiratory manifestations in SLE, as also to correlate the findings as observed by different diagnostic methods. It was a single centre cross-sectional observational study conducted at rheumatology clinic, IPGME&R, Kolkata. Patients suffering from chronic airways obstruction, upper airway diseases, left ventricular failure and lung cancer were all excluded from the study...
February 2012: Journal of the Indian Medical Association
https://www.readbyqxmd.com/read/23006581/intrinsic-endobronchial-obstructions-in-children-from-turkey-evaluation-of-2-555-flexible-bronchoscopic-procedures
#19
MULTICENTER STUDY
Arif Kut, Erkan Cakir, Yasemin Gokdemir, Levent Midyat, Refika Ersu, Ela Erdem, Bulent Karadag, Fazilet Karakoc
BACKGROUND: Endobronchial obstructions are rarely seen in children and are often misdiagnosed resulting in delay of definitive treatment. A variety of diseases can cause endobronchial obstructions in childhood, but data is limited as to the frequency, distribution and clinical characteristics of endobronchial obstructions diagnosed with flexible bronchoscopy (FB). OBJECTIVE: To document endobronchial obstructions detected by FB. METHODS: FB results from three pediatric pulmonology centers in Istanbul were evaluated...
2013: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/22973562/pharmaceutical-aerosols-for-the-treatment-and-prevention-of-tuberculosis
#20
REVIEW
Shumaila N M Hanif, Lucila Garcia-Contreras
Historically, pharmaceutical aerosols have been employed for the treatment of obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease, but in the past decades their use has been expanded to treat lung infections associated with cystic fibrosis and other respiratory diseases. Tuberculosis (TB) is acquired after inhalation of aerosol droplets containing the bacilli from the cough of infected individuals. Even though TB affects other organs, the lungs are the primary site of infection, which makes the pulmonary route an ideal alternative route to administer vaccines or drug treatments...
2012: Frontiers in Cellular and Infection Microbiology
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