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JOURNAL ARTICLE
Akshay Bhamidipati, Nishit Mummareddy, Seoiyoung Ahn, Gabriel Bendfeldt, Alexander T Lyons, Surya Gangavarapu, Jeffrey Chen, Jacob Jo, Naveed Kamal, Steven G Roth, Michael T Froehler, Rohan V Chitale, Matthew R Fusco
BACKGROUND: Post-mechanical thrombectomy (MT) intracranial hemorrhage (ICH) is a major source of morbidity in treated acute ischemic stroke patients with large vessel occlusion. ICH expansion may further contribute to morbidity. We sought to identify factors associated with ICH expansion on imaging evaluation post-MT. METHODS: We performed a retrospective cohort study of patients undergoing MT at a single comprehensive stroke center. Per protocol, patients underwent dual-energy head CT (DEHCT) post-MT followed by a 24-h interval non-contrast enhanced MRI...
April 17, 2024: Interventional Neuroradiology
#2
JOURNAL ARTICLE
Maud Wang, Hans Henkes, Sherief Ghozy, James E Siegler, Hamza Shaikh, Jane Khalife, Mohamad Abdalkader, Piers Klein, Thanh N Nguyen, Jeremy J Heit, Ahmad Sweid, Kareem El Naamani, Robert W Regenhardt, Jose Danilo Bengzon Diestro, Nicole M Cancelliere, Abdelaziz Amllay, Lukas Meyer, Anne Dusart, Flavio Bellante, Géraud Forestier, Aymeric Rouchaud, Suzana Saleme, Charbel Mounayer, Jens Fiehler, Anna Luisa Kühn, Ajit S Puri, Christian Dyzmann, Peter T Kan, Marco Colasurdo, Gaultier Marnat, Jérôme Berge, Xavier Barreau, Igor Sibon, Simona Nedelcu, Nils Henninger, Charlotte Weyland, Thomas R Marotta, Christopher J Stapleton, James D Rabinov, Takahiro Ota, Shogo Dofuku, Leonard Ll Yeo, Benjamin Y Q Tan, Juan Carlos Martinez-Gutierrez, Sergio Salazar-Marioni, Sunil Sheth, Leonardo Renieri, Carolina Capirossi, Ashkan Mowla, Stavropoula I Tjoumakaris, Pascal Jabbour, Priyank Khandelwal, Arundhati Biswas, Frédéric Clarençon, Mahmoud Elhorany, Kevin Premat, Iacopo Valente, Alessandro Pedicelli, João Pedro Filipe, Ricardo Varela, Miguel Quintero-Consuegra, Nestor R Gonzalez, Markus A Möhlenbruch, Jessica Jesser, Vincent Costalat, Adrien Ter Schiphorst, Vivek Yedavalli, Pablo Harker, Lina M Chervak, Yasmin Aziz, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Ajith J Thomas, Cheng-Yang Hsieh, David S Liebeskind, Răzvan Alexandru Radu, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Aman B Patel, Vitor Mendes Pereira, Robert Fahed, Boris Lubicz, Adam A Dmytriw, Adrien Guenego
PURPOSE: Our purpose was to assess the efficacy and safety of the pRESET LITE stent retriever (Phenox, Bochum, Germany), designed for medium vessel occlusion (MeVO) in acute ischemic stroke (AIS) patients with a primary MeVO. METHODS: We performed a retrospective analysis of the MAD MT Consortium, an integration of prospectively maintained databases at 37 academic institutions in Europe, North America, and Asia, of AIS patients who underwent mechanical thrombectomy with the pRESET LITE stent retriever for a primary MeVO...
February 21, 2024: Neuroradiology
#3
JOURNAL ARTICLE
Alessandro Sgreccia, Jean-Philippe Desilles, Vincent Costalat, Cyril Dargazanli, Romain Bourcier, Guillaume Tessier, Aymeric Rouchaud, Suzana Saleme, Laurent Spelle, Jildaz Caroff, Gaultier Marnat, Xavier Barreau, Frédéric Clarençon, Eimad Shotar, François Eugene, Emmanuel Houdart, Benjamin Gory, François Zhu, Julien Labreuche, Michel Piotin, Bertrand Lapergue, Arturo Consoli
BACKGROUND: The aim of this study was to report the results of a subgroup analysis of the ASTER2 trial (Effect of Thrombectomy With Combined Contact Aspiration and Stent Retriever vs Stent Retriever Alone on Revascularization in Patients With Acute Ischemic Stroke and Large Vessel Occlusion) comparing the safety and efficacy of the combined technique (CoT) and stent retriever as a first-line approach in internal carotid artery (ICA) terminus±M1-middle cerebral artery (M1-MCA) and isolated M1-MCA occlusions...
December 21, 2023: Stroke; a Journal of Cerebral Circulation
#4
JOURNAL ARTICLE
Jennifer Sartor-Pfeiffer, Mirjam Lingel, Maria-Ioanna Stefanou, Markus Krumbholz, Florian Hennersdorf, Ulrike Ernemann, Sven Poli, Katharina Feil, Ulf Ziemann, Annerose Mengel
BACKGROUND: Over 50% of acute ischemic stroke (AIS) patients present with minor neurological deficits, and optimal treatment is still debated. The randomized PRISMS trial did not show beneficial effects of intravenous thrombolysis (IVT) in unselected patients with minor stroke and non-disabling neurological deficits. PURPOSE: The study aimed to evaluate if AIS patients with minor stroke may benefit from computed-tomography-perfusion (CTP)-guided IVT. The primary endpoint was good functional outcomes, defined as a modified Rankin Scale score of 0-2 at 90 days...
2023: Frontiers in Neurology
#5
JOURNAL ARTICLE
Mohamad Ezzeldin, Courtney Hill, Ali Kerro, Eryn Percenti, Adam Delora, Juan Santos, Hamzah Saei, Lisa Greco, Rime Ezzeldin, Mohammad El-Ghanem, Yazan Alderazi, Yana Kim, Cathleen Poitevint, Osman Mir
BACKGROUND AND PURPOSE: Tenecteplase is the thrombolytic drug of choice for acute ischemic stroke (AIS) as it has unique pharmacologic properties, along with results demonstrating its non-inferiority compared to alteplase. However, there are contradictory data concerning the risk of intracranial hemorrhage. The purpose of the study was to report the rate and patterns of symptomatic intracranial hemorrhage (sICH) in AIS patients after thrombolysis with tenecteplase compared to alteplase...
October 2023: Curēus
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JOURNAL ARTICLE
D M Murtazalieva, A R Zakaryaeva, T D Soshina, M A Zolotov, V A Parfenov
OBJECTIVE: To assess the efficacy and safety of thrombolytic therapy (TLT) with Revelisa in patients with ischemic stroke (IS). MATERIAL AND METHODS: The retrospective study included the data of 72 patients (mean age 64.0±17.1) with IS who were admitted to the Regional Vascular Center of the V.V. Veresaev City Clinical Hospital within the first 4.5 hours after the disease onset in the period August 2022 through February 2023. All patients underwent clinical, instrumental and laboratory examinations under the reperfusion therapy protocol...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#7
JOURNAL ARTICLE
Manuel Cappellari, Giovanni Pracucci, Valentina Saia, Enrico Fainardi, Ilaria Casetta, Fabrizio Sallustio, Maria Ruggiero, Marco Longoni, Luigi Simonetti, Andrea Zini, Guido Andrea Lazzarotti, Nicola Giannini, Valerio Da Ros, Marina Diomedi, Stefano Vallone, Guido Bigliardi, Nicola Limbucci, Patrizia Nencini, Daniele Ajello, Simona Marcheselli, Nicola Burdi, Giovanni Boero, Sandra Bracco, Rossana Tassi, Andrea Boghi, Andrea Naldi, Francesco Biraschi, Ettore Nicolini, Lucio Castellan, Massimo Del Sette, Luca Allegretti, Annalisa Sugo, Orazio Buonomo, Cristina Dell'Aera, Andrea Saletti, Alessandro De Vito, Elvis Lafe, Federico Mazzacane, Mauro Bergui, Paolo Cerrato, Paola Feraco, Silvio Piffer, Raffaele Augelli, Federica Vit, Roberto Gasparotti, Mauro Magoni, Simone Comelli, Maurizio Melis, Roberto Menozzi, Umberto Scoditti, Nicola Cavasin, Adriana Critelli, Francesco Causin, Claudio Baracchini, Giuseppe Guzzardi, Roberto Tarletti, Pietro Filauri, Berardino Orlandi, Andrea Giorgianni, Lucia Princiotta Cariddi, Mariangela Piano, Cristina Motto, Ivan Gallesio, Federica Nicoletta Sepe, Giuseppe Romano, Maria Federico Grasso, Alfredo Pauciulo, Annalisa Rizzo, Alessio Comai, Enrica Franchini, Luigi Sicurella, Gianluca Galvano, Marina Mannino, Salvatore Mangiafico, Danilo Toni, On Behalf Of The Iretas Group
INTRODUCTION: The aim of this study was to compare the outcomes of patients treated with intravenous thrombolysis (IVT) <4.5 h after symptom onset plus mechanical thrombectomy (MT) <6 h with those treated with IVT alone <4.5 h for minor stroke (NIHSS ≤5) with large vessel occlusion (LVO) in the anterior circulation. PATIENTS AND METHODS: Patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) and in the Italian centers included in the SITS-ISTR were analyzed...
July 17, 2023: Neurological Sciences
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MULTICENTER STUDY
Philipp Baumgartner, Lucas Kook, Valerian L Altersberger, Henrik Gensicke, Elena Ardila-Jurado, Georg Kägi, Alexander Salerno, Patrik Michel, Kiran M Gopisingh, Paul J Nederkoorn, Jan F Scheitz, Christian H Nolte, Mirjam R Heldner, Marcel Arnold, Charlotte Cordonnier, Lucie Della Schiava, Christian Hametner, Peter A Ringleb, Ronen R Leker, Hamza Jubran, Andreas R Luft, Stefan T Engelter, Susanne Wegener
BACKGROUND: Retinal artery occlusion (RAO) may lead to irreversible blindness. For acute RAO, intravenous thrombolysis (IVT) can be considered as treatment. However, due to the rarity of RAO, data about IVT safety and effectiveness is limited. METHODS: From the multicenter database ThRombolysis for Ischemic Stroke Patients (TRISP), we retrospectively analyzed visual acuity (VA) at baseline and within 3 months in IVT and non-IVT treated RAO patients. Primary outcome was difference of VA between baseline and follow up (∆VA)...
December 2023: European Stroke Journal
#9
JOURNAL ARTICLE
Seoiyoung Ahn, Steven G Roth, Nishit Mummareddy, Yeji Ko, Akshay Bhamidipati, Jacob Jo, Julie DiNitto, Matthew R Fusco, Rohan V Chitale, Michael T Froehler
OBJECTIVES: Dual-energy CT allows differentiation between blood and iodinated contrast. This study aims to determine the predictive value of contrast density and volume on post-thrombectomy dual-energy CT for delayed hemorrhagic transformation and its impact on 90-day outcomes. MATERIALS AND METHODS: A retrospective analysis was performed on patients who underwent thrombectomy for anterior circulation large-vessel occlusion at a comprehensive stroke center from 2018-2021...
August 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#10
JOURNAL ARTICLE
Manuel Cappellari, Valentina Saia, Giovanni Pracucci, Ilaria Casetta, Enrico Fainardi, Fabrizio Sallustio, Maria Ruggiero, Michele Romoli, Luigi Simonetti, Andrea Zini, Guido Andrea Lazzarotti, Giovanni Orlandi, Stefano Vallone, Guido Bigliardi, Leonardo Renieri, Patrizia Nencini, Vittorio Semeraro, Giovanni Boero, Sandra Bracco, Rossana Tassi, Davide Castellano, Andrea Naldi, Francesco Biraschi, Ettore Nicolini, Bruno Del Sette, Laura Malfatto, Luca Allegretti, Tiziana Tassinari, Agostino Tessitore, Ludovica Ferraù, Andrea Saletti, Alessandro De Vito, Elvis Lafe, Anna Cavallini, Mauro Bergui, Giovanni Bosco, Paola Feraco, Valeria Bignamini, Nicolò Mandruzzato, Federica Vit, Dikran Mardighian, Mauro Magoni, Simone Comelli, Maurizio Melis, Roberto Menozzi, Umberto Scoditti, Giacomo Cester, Federica Viario, Alessandro Stecco, Thomas Fleetwood, Pietro Filauri, Simona Sacco, Andrea Giorgianni, Lucia Princiotta Cariddi, Mariangela Piano, Cristina Motto, Ivan Gallesio, Federica Sepe, Giuseppe Romano, Maria Federica Grasso, Emilio Lozupone, Antonio Fasano, Alessio Comai, Erica Franchini, Stefano Bruni, Mauro Silvestrini, Luigi Chiumarulo, Marco Petruzzelli, Marco Pavia, Paolo Invernizzi, Edoardo Puglielli, Alfonsina Casalena, Alessandro Pedicelli, Giovanni Frisullo, Pietro Amistà, Monia Russo, Massimiliano Allegritti, Stefano Caproni, Salvatore Mangiafico, Danilo Toni
Efficacy and safety of mechanical thrombectomy (MT) for stroke with posterior circulation large vessel occlusion (LVO) is still under debate. We aimed to compare the outcomes of stroke patients with posterior circulation LVO treated with intravenous thrombolysis (IVT) (< 4.5 h after symptom onset) plus MT < 6 h after symptom onset with those treated with IVT alone (< 4.5 h after symptom onset). Patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) and in the Italian centers included in the SITS-ISTR were analysed...
June 28, 2023: Journal of Thrombosis and Thrombolysis
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JOURNAL ARTICLE
Xinmao Wu, Wendan Tao, Yanan Wang, Qian Wu, Chen Ye, Xindi Song, Xiaonan Guo, Junfeng Liu
Introduction Previous preclinical studies reported that the level of serum EphrinA1 was associated with blood-brain barrier (BBB) disruption, while its role in predicting parenchymal hematoma (PH) after ischemic stroke has not been investigated. We aimed to explore the association between the level of serum EphrinA1 and PH in patients with ischemic stroke. Methods Patients with ischemic stroke within 24 hours after onset from West China hospital, Sichuan University, were prospectively enrolled between January 2017 and December 2019...
April 27, 2023: Cerebrovascular Diseases
#12
JOURNAL ARTICLE
Elyar Sadeghi-Hokmabadi, Farhad Mirzaei, Mohammad Yazdchi, Javad Jalili, Yalda Sadeghpour, Behzad Nemati-Anari, Mehdi Farhoudi, Pouneh HamianRoumiani
INTRODUCTION: The optimal timing for decompressive hemicraniectomy (DHC) after intravenous thrombolysis (IVT) remains unclear. This study in patients with acute ischemic stroke treated with IVT aimed to assess the safety of DHC and patient outcome. METHODS: Data was extracted from the Tabriz stroke registry from June 2011 up to September 2020. In all, 881 patients were treated with IVT. Among these, 23 patients underwent DH. Six patients were excluded due to symptomatic intracranial hemorrhage (parenchymal hematoma type 2 based on SITS-MOST definition) after IVT, but other types of bleeding after venous thrombolysis, including HI1, HI2, and PH1 were not excluded; so the remaining 17 patients were enrolled in the study...
March 28, 2023: BMC Neurology
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JOURNAL ARTICLE
Giordano Lacidogna, Francesca Pitocchi, Alfredo Paolo Mascolo, Federico Marrama, Federica D'Agostino, Alessandro Rocco, Francesco Mori, Ilaria Maestrini, Federico Sabuzi, Armando Cavallo, Daniele Morosetti, Francesco Garaci, Francesca Di Giuliano, Roberto Floris, Fabrizio Sallustio, Marina Diomedi, Valerio Da Ros
BACKGROUND: CT perfusion (CTP) is used in patients with anterior circulation acute ischemic stroke (AIS) for predicting the final infarct volume (FIV). Tandem occlusion (TO), involving both intracranial large vessels and the ipsilateral cervical internal carotid artery could generate hemodynamic changes altering perfusion parameters. Our aim is to evaluate the accuracy of CTP in the prediction of the FIV in TOs. METHODS: consecutive patients with AIS due to middle cerebral artery occlusion, referred to a tertiary stroke center between March 2019 and January 2021, with an automated CTP and successful recanalization (mTICI = 2b - 3) after endovascular treatment were retrospectively included in the tandem group (TG) or in the control group (CG)...
February 16, 2023: Journal of Personalized Medicine
#14
JOURNAL ARTICLE
Natasha Ironside, Ching-Jen Chen, Reda M Chalhoub, Ryan T Kellogg, Dale Ding, Ilko Maier, Sami Al Kasab, Pascal Jabbour, Joon-Tae Kim, Stacey Q Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Adam S Arthur, Shinichi Yoshimura, Jonathan A Grossberg, Ali Alawieh, Isabel Fragata, Adam J Polifka, Justin R Mascitelli, Joshua W Osbun, Charles Matouk, Michael R Levitt, Travis M Dumont, Hugo H Cuellar-Saenz, Richard Williamson, Daniele G Romano, Roberto Javier Crosa, Benjamin Gory, Maxim Mokin, Mark Moss, Kaustubh Limaye, Peter Kan, Alejandro M Spiotta, Min S Park
BACKGROUND: Reducing intracranial hemorrhage (ICH) can improve patient outcome in acute ischemic stroke (AIS) intervention. We sought to identify ICH risk factors after AIS thrombectomy. METHODS: This is a retrospective review of the Stroke Thrombectomy and Aneurysm Registry (STAR) database. All patients who underwent AIS thrombectomy with available ICH data were included. Multivariable regression models were developed to identify predictors of ICH after thrombectomy...
February 1, 2023: Journal of Neurointerventional Surgery
#15
JOURNAL ARTICLE
M A Soldatov, L V Klimov, A P Tolmachev, T V Kiseleva, O V Androfagina, E M Beketova, S N Belkina, D N Borisov, D Yu Karpov, M S Krasyuk, M V Kucheryavaya, Yu D Minina, D G Novikov, N V Rogozhnikova, S V Tabakman, Yu A Teliatnik, K V Tretyakov, A S Fadeeva, D S Khan, A N Chirkov, N A Marskaya, N A Shamalov
OBJECTIVE: Evaluation of the safety and effectiveness of thrombolytic therapy (TLT) with the drug Revelisa (alteplase) in patients with ischemic stroke (AI) in real clinical practice. MATERIAL AND METHODS: An open prospective multicenter non-interventional register study was conducted, which included 550 patients with AI - 259 (47.1%) women and 291 (52.9%) men; average age 67.7±12.6 years. All included patients underwent TLT with the drug Revelisa within 4...
2022: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#16
JOURNAL ARTICLE
Soumya Krishnamoorthy, P N Sylaja, Sapna Erat Sreedharan, Gurpreet Singh, Deepa Damayanthi, Srinivas Gopala, U K Madhusoodanan, Harikrishnan Ramachandran
OBJECTIVES: Hemorrhagic transformation (HT) is a complication occurring in patients with acute ischemic stroke (AIS) either spontaneously or post-thrombolysis leading to significant morbidity and mortality. We assessed circulating matrix metalloproteinase-9 (MMP-9), Claudin-5, and soluble serum stimulation-2 (sST2) in HT and stroke severity in AIS based on their temporal distribution. MATERIALS AND METHODS: We prospectively enrolled 111 AIS patients within 12 h from onset...
November 14, 2022: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#17
MULTICENTER STUDY
Valerian L Altersberger, Norman Rusche, Nicolas Martinez-Majander, Christian Hametner, Jan F Scheitz, Hilde Henon, Maria Luisa Dell'Acqua, Davide Strambo, Jeffrey Stolp, Mirjam R Heldner, Ilaria Grisendi, Dejana R Jovanovic, Yannick Bejot, Alessandro Pezzini, Ronen R Leker, Georg Kägi, Susanne Wegener, Carlo W Cereda, Erik Lindgren, George Ntaios, Ines Piot, Alexandros A Polymeris, Philippe A Lyrer, Silja Räty, Gerli Sibolt, Marjaana Tiainen, Miriam Heyse, Hebun Erdur, Olfa Kaaouana, Visnja Padjen, Marialuisa Zedde, Marcel Arnold, Paul J Nederkoorn, Patrik Michel, Guido Bigliardi, Andrea Zini, Charlotte Cordonnier, Christian H Nolte, Peter A Ringleb, Sami Curtze, Stefan T Engelter, Henrik Gensicke
BACKGROUND: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely influence individual IVT treatment decisions. Using data from a large IVT registry, we aimed to provide more evidence on safety of IVT in the very elderly. METHODS: In this prospective multicenter study from the TRISP (Thrombolysis in Ischemic Stroke Patients) registry, we compared patients ≥90 years with those <90 years using symptomatic intracranial hemorrhage (ECASS [European Cooperative Acute Stroke Study]-II criteria), death, and poor functional outcome in survivors (modified Rankin Scale score 3-5 for patients with prestroke modified Rankin Scale score ≤2 and modified Rankin Scale score 4-5 for patients prestroke modified Rankin Scale ≥3) at 3 months as outcomes...
December 2022: Stroke; a Journal of Cerebral Circulation
#18
JOURNAL ARTICLE
Xinwei He, Baomei Lin, Taotao Tao, Qiuyue Chen, Jinhua Wang, Jiaolei Jin
BACKGROUND: Serum calcium abnormalities have been determined to be associated with the risk and outcome of stroke. The aim of the present study was to examine the associations of serum calcium with vascular recanalization, symptomatic intracranial haemorrhage and functional outcome in stroke patients after mechanical thrombectomy. METHODS: A total of 192 patients treated with mechanical thrombectomy for anterior circulation large vessel occlusion were consecutively included from August 2017 to June 2021...
September 2, 2022: BMC Neurology
#19
JOURNAL ARTICLE
Jean-Marc Olivot, Stephanos Finitsis, Bertrand Lapergue, Gaultier Marnat, Igor Sibon, Sebastien Richard, Alain Viguier, Christophe Cognard, Mikael Mazighi, Benjamin Gory
OBJECTIVE: Despite a 90% reperfusion rate, only 50% of patients with anterior circulation large vessel occlusion-related acute ischemic stroke (LVO-AIS) have a functional recovery at 3 months. Parenchymal hematoma (PH) is a predictor of poor outcome after endovascular treatment (EVT). We aim to investigate the relationship between the delay from onset to reperfusion, the occurrence of PH, and functional outcome. METHODS: The Endovascular Treatment in Ischemic Stroke (ETIS) registry is an ongoing prospective observational study...
November 2022: Annals of Neurology
#20
JOURNAL ARTICLE
Lulu Chen, Ziqi Xu, Chen Zhang, Yachen Ji, Xianjun Huang, Weimin Yang, Zhiming Zhou, Shuiping Wang, Kai Wang, Benyan Luo, Jingye Wang
Background and Purpose: Almost half of the patients exhibit futile recanalization after thrombectomy; however, the early postoperative predictors of futile recanalization remain unclear. We analyzed the relationship of post-thrombectomy ASPECTS (Post-ASPECTS) with 90-day prognosis and hemorrhagic transformation (HT). Methods: We collected data from patients with acute ischemic stroke (AIS) with anterior-circulation large vessel occlusion (ACLVO) who were treated via thrombectomy within 10 h in 3 hospitals...
2022: Frontiers in Neurology
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