Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
Nowshin Papri, Zhahirul Islam, Gulshan Ara, Tamal Saha, Sonja E Leonhard, Hubert P Endtz, Bart C Jacobs, Quazi D Mohammad
BACKGROUND AND AIMS: Considerable variation in clinical practice for management of Guillain-Barré syndrome (GBS) has been observed worldwide. Diagnosis and treatment are challenging in low- and middle-income countries (LMIC) due to lack of facilities and treatment availability. We aimed to evaluate current clinical practice and limitations and to provide recommendation for GBS management in low-resource settings. METHODS: We conducted an explanatory-sequential mixed-methods survey among neurologists and internists working in tertiary and secondary government hospitals in Bangladesh...
December 2023: Journal of the Peripheral Nervous System: JPNS
#22
JOURNAL ARTICLE
Laia Llucià-Carol, Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Miquel Lledós, Cristina Gallego-Fabrega, Jesús Martin-Campos, Joan Martí-Fàbregas, Ana Aguilera-Simón, Anna M Planas, Marta L DeDiego, Alicia de Felipe Mimbrera, Jaime Masjuan, Sebastián García-Madrona, Tomás Segura, Esther González-Villar, Gemma Serrano-Heras, Ana Domínguez Mayoral, Paloma Menéndez-Valladares, Joan Montaner, Isabelle Migeotte, Souad Rahmouni, Gilles Darcis, David Bernardo, Silvia Rojo, Eva C Schulte, Ulrike Protzer, Lisa Fricke, Christof Winter, Mari E K Niemi, Mattia Cordioli, Pilar Delgado, Israel Fernández-Cadenas
We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific aetiology of IS. We used SUPERGNOVA to identify genome regions that correlate between the IS-COV cohort (73 IS-COV cases vs. 701 population controls) and different aetiological subtypes. Polygenic risk scores (PRSs) for each subtype were generated and tested in the IS-COV cohort using PRSice-2 and PLINK to find genetic associations. Both analyses used the IS-COV cohort and GWAS from MEGASTROKE (67,162 stroke patients vs...
August 30, 2023: International Journal of Molecular Sciences
#23
REVIEW
Verónica Schiariti, Angela Shierk, Elaine E Stashinko, Theresa Sukal-Moulton, Robin S Feldman, Clara Aman, M Carolina Mendoza-Puccini, Joline E Brandenburg
AIM: This study describes the process of updating the cerebral palsy (CP) common data elements (CDEs), specifically identifying tools that capture the impact of chronic pain on children's functioning. METHOD: Through a partnership between the American Academy for Cerebral Palsy and Developmental Medicine and the National Institute of Neurological Disorders and Stroke (NINDS), the CP CDEs were developed as data standards for clinical research in neuroscience. Chronic pain was underrepresented in the NINDS CP CDEs version 1...
August 31, 2023: Developmental Medicine and Child Neurology
#24
JOURNAL ARTICLE
Stephanie N Blandford, Neva J Fudge, Craig S Moore
BACKGROUND: Cerebrospinal fluid (CSF) is an important sampling site for putative biomarkers and contains immune cells. CXCL10 is a multiple sclerosis (MS)-relevant chemokine that is present in the injured central nervous system and recruits CXCR3+ immune cells toward injured tissues. OBJECTIVE: Perform a comprehensive evaluation to determine a potential relationship between CXCL10 and various immune cell subsets in the CNS of MS and control cases. METHODS: In MS and control cases, CXCL10 was measured in the CSF and plasma by ELISA...
August 1, 2023: Biomolecules
#25
JOURNAL ARTICLE
Vikas Sharma, Rahul Kaushik, Krishan Kumar, Akanksha Gupta, Snigdha Srivastava, Rajan Kumar Kurmi
Epilepsy is the most general, extensive, and severe neurological disorder, affecting more than 50 million individuals globally. Initially, conventional medicines and simple salts like potassium bromide were employed as antiepileptic medication candidates. Nowadays, many anticonvulsant drugs have been discovered as first-generation and second-generation and newer drugs and are still in development phases. The pharmacophore-based drug design process includes pharmacophore modeling and validation, pharmacophore-based virtual screening, virtual hits profiling, and lead identification with special reference...
August 22, 2023: Central Nervous System Agents in Medicinal Chemistry
#26
JOURNAL ARTICLE
Derek M Griffith, Amytis Towfighi, Spero M Manson, Erica L Littlejohn, Lesli E Skolarus
A National Institute of Neurological Disorders and Stroke working group developed the Determinants of Inequities in Neurological Disease, Health, and Well-being framework. Our goal was to guide and inspire a new generation of neurologic research that pushes the field to design and test new approaches in pursuit of health equity, population health, and social justice. We seek to expand the lens of those looking to reduce or eliminate racial, socioeconomic status, and other inequities in neurologic disease, health, and well-being to improve our collective ability to create research, programs, and policies that lead to larger, more impactful, and more sustainable change in neurologic disease patterns...
August 15, 2023: Neurology
#27
JOURNAL ARTICLE
David L Brody, Rebecca F Gottesman, Gerald Griffin, Zayd M Khaliq, Daniel T Lackland, Geoff Ling, Nimish Mohile
BACKGROUND AND OBJECTIVES: In 2020, the National Institute of Neurological Disorders and Stroke (NINDS) leadership asked its Advisory Council to review NINDS efforts in the domains of diversity, equity, inclusion, and health inequities. Part of these efforts involved a focus on health equity training and health equity research workforce diversification activities. The objective of this article was to summarize the findings and make recommendations regarding these training activities. METHODS: A subgroup of the National Advisory Neurological Disorders and Stroke Council Working Group for Health Disparities and Inequities in Neurological Disorders was engaged to advise NINDS leadership in the domain of diversity in health equity training...
August 15, 2023: Neurology
#28
JOURNAL ARTICLE
Sara Dodson, Shardell Spriggs, Ryan Calabrese, Stacey Chambers, Marguerite Matthews, Cheryse Sankar, Alisa Schaefer, Christine Swanson-Fischer, Devon Crawford, George Umanah, Richard T Benson
BACKGROUND AND OBJECTIVES: As detailed throughout this special issue, the National Institute of Neurological Disorders and Stroke (NINDS) recently undertook a strategic planning effort to guide the Institute's efforts and priorities in health disparities and health equity (HD/HE) research. One input into this effort was to conduct a 5-year longitudinal, in-depth analysis of NINDS-supported HD/HE research newly funded between the years 2016 and 2020. The goals of this analysis were to describe NINDS's portfolio according to consistent, contemporary definitions and HD/HE disciplinary theory...
August 15, 2023: Neurology
#29
JOURNAL ARTICLE
A Susana Ramírez, Stephanie M Mohl, Christin Veasley, Sameer A Sheth
Optimizing health care decisions relies critically on the availability of health-related information appropriate to the specific needs and circumstances of the individual. Abundant research has demonstrated that information relevant to health care decision-making reflects disparities along multiple axes of sex, race, socioeconomic status, geography, sexual orientation, and other factors. Compounding the problem is that mechanisms of access to information themselves, increasingly recognized as part of the social determinants of health, can perpetuate and even exacerbate these disparities...
August 15, 2023: Neurology
#30
JOURNAL ARTICLE
Erica L Littlejohn, Naomi E Booker, Stacey Chambers, Jemima A Akinsanya, Cheryse A Sankar, Richard T Benson
OBJECTIVES: The purpose of this study was to analyze the National Institute of Neurological Disorders and Stroke (NINDS) Request for Information (RFI) input from the public-including health care providers, researchers, patients, patient advocates, caregivers, advocacy organizations, professional societies, and private and academic stakeholders with an interest in health disparities (HDs) in neurologic disease. RFI questions were structured to solicit input on what stakeholders believe are neurologic disease HD research priorities, drivers of health inequity, and potential interventions...
August 15, 2023: Neurology
#31
Karen C Johnston, Edwin Trevathan
Neurologic mortality is increasing in the United States and is occurring in an inequitable manner. There is a major need for innovative research strategies to eliminate these inequities. In 2020, the National Institute of Neurological Disorders and Stroke (NINDS) embarked on a health equity strategic planning process, which culminated in a 3-day public workshop and research recommendations provided by a working group of its National Advisory Neurological Disorders and Stroke Council (NANDSC WG) to the NINDS...
August 15, 2023: Neurology
#32
Clinton B Wright, Francesca Bosetti, James I Koenig, L Scott Janis
No abstract text is available yet for this article.
August 2023: Stroke; a Journal of Cerebral Circulation
#33
JOURNAL ARTICLE
Manuel Cappellari, Giovanni Pracucci, Valentina Saia, Enrico Fainardi, Ilaria Casetta, Fabrizio Sallustio, Maria Ruggiero, Marco Longoni, Luigi Simonetti, Andrea Zini, Guido Andrea Lazzarotti, Nicola Giannini, Valerio Da Ros, Marina Diomedi, Stefano Vallone, Guido Bigliardi, Nicola Limbucci, Patrizia Nencini, Daniele Ajello, Simona Marcheselli, Nicola Burdi, Giovanni Boero, Sandra Bracco, Rossana Tassi, Andrea Boghi, Andrea Naldi, Francesco Biraschi, Ettore Nicolini, Lucio Castellan, Massimo Del Sette, Luca Allegretti, Annalisa Sugo, Orazio Buonomo, Cristina Dell'Aera, Andrea Saletti, Alessandro De Vito, Elvis Lafe, Federico Mazzacane, Mauro Bergui, Paolo Cerrato, Paola Feraco, Silvio Piffer, Raffaele Augelli, Federica Vit, Roberto Gasparotti, Mauro Magoni, Simone Comelli, Maurizio Melis, Roberto Menozzi, Umberto Scoditti, Nicola Cavasin, Adriana Critelli, Francesco Causin, Claudio Baracchini, Giuseppe Guzzardi, Roberto Tarletti, Pietro Filauri, Berardino Orlandi, Andrea Giorgianni, Lucia Princiotta Cariddi, Mariangela Piano, Cristina Motto, Ivan Gallesio, Federica Nicoletta Sepe, Giuseppe Romano, Maria Federico Grasso, Alfredo Pauciulo, Annalisa Rizzo, Alessio Comai, Enrica Franchini, Luigi Sicurella, Gianluca Galvano, Marina Mannino, Salvatore Mangiafico, Danilo Toni, On Behalf Of The Iretas Group
INTRODUCTION: The aim of this study was to compare the outcomes of patients treated with intravenous thrombolysis (IVT) <4.5 h after symptom onset plus mechanical thrombectomy (MT) <6 h with those treated with IVT alone <4.5 h for minor stroke (NIHSS ≤5) with large vessel occlusion (LVO) in the anterior circulation. PATIENTS AND METHODS: Patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) and in the Italian centers included in the SITS-ISTR were analyzed...
July 17, 2023: Neurological Sciences
#34
JOURNAL ARTICLE
Pietro Maggi, Colin Vanden Bulcke, Edoardo Pedrini, Céline Bugli, Amina Sellimi, Maxence Wynen, Anna Stölting, William A Mullins, Grigorios Kalaitzidis, Valentina Lolli, Gaetano Perrotta, Souraya El Sankari, Thierry Duprez, Xu Li, Peter A Calabresi, Vincent van Pesch, Daniel S Reich, Martina Absinta
BACKGROUND: Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed even in patients taking high-efficacy disease-modifying therapy, including B-cell depletion. Given that CAL are a major determinant of clinical progression, including progression independent of relapse activity (PIRA), understanding the predicted activity and real-world effects of targeting specific lymphocyte populations is critical for designing next-generation treatments to mitigate chronic inflammation in MS...
July 10, 2023: EBioMedicine
#35
JOURNAL ARTICLE
Ming Mao, Chaoqun Wang, Tingting Hou, Xiaolei Han, Rui Liu, Qi Han, Yi Dong, Jiafeng Wang, Cuicui Liu, Lin Cong, Yume Imahori, Davide Liborio Vetrano, Yongxiang Wang, Yifeng Du, Chengxuan Qiu
BACKGROUND: Evidence has emerged that altered ventricular electrocardiogram profiles are associated with dementia, but the neuropathological mechanisms underlying their associations are poorly understood. OBJECTIVE: To investigate the interrelationships of ventricular electrocardiogram profiles with dementia and plasma Alzheimer's disease (AD) biomarkers among older adults. METHODS: This population-based cross-sectional study included 5,153 participants (age ≥65 years; 57...
July 5, 2023: Journal of Alzheimer's Disease: JAD
#36
JOURNAL ARTICLE
Jonás A Aguirre-Liguori, Abraham Morales-Cruz, Brandon S Gaut, Santiago Ramírez-Barahona
Genomic data and machine learning approaches have gained interest due to their potential to identify adaptive genetic variation across populations and to assess species vulnerability to climate change. By identifying gene-environment associations for putatively adaptive loci, these approaches project changes to adaptive genetic composition as a function of future climate change (genetic offsets), which are interpreted as measuring the future maladaptation of populations due to climate change. In principle, higher genetic offsets relate to increased population vulnerability and therefore can be used to set priorities for conservation and management...
June 30, 2023: Molecular Ecology Resources
#37
JOURNAL ARTICLE
Lu-Chen Weng, Shaan Khurshid, Sophia Gunn, Ludovic Trinquart, Kathryn L Lunetta, Huichun Xu, Emelia J Benjamin, Patrick T Ellinor, Christopher D Anderson, Steven A Lubitz
BACKGROUND: Stroke is a leading cause of death and disability worldwide. Atrial fibrillation (AF) is a common cause of stroke but may not be detectable at the time of stroke. We hypothesized that an AF polygenic risk score (PRS) can discriminate between cardioembolic stroke and noncardioembolic strokes. METHODS: We evaluated AF and stroke risk in 26 145 individuals of European descent from the Stroke Genetics Network case-control study. AF genetic risk was estimated using 3 recently developed PRS methods (LDpred-funct-inf, sBayesR, and PRS-CS) and 2 previously validated PRSs...
July 2023: Stroke; a Journal of Cerebral Circulation
#38
JOURNAL ARTICLE
Hedda Luise Verhasselt, Elakiya Ramakrishnan, Melina Schlag, Julian R Marchesi, Jan Buer, Christoph Kleinschnitz, Tim Hagenacker, Andreas Totzeck
An altered gut microbiota is a possible contributing pathogenic factor in myasthenia gravis (MG), an autoimmune neuromuscular disease. However, the significance of the fungal microbiome is an understudied and neglected part of the intestinal microbiome in MG. We performed a sub-analysis of the MYBIOM study including faecal samples from patients with MG ( n = 41), non-inflammatory neurological disorder (NIND, n = 18), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP, n = 6) and healthy volunteers (n = 12) by sequencing the internal transcribed spacer 2 (ITS2)...
May 13, 2023: Journal of Fungi (Basel, Switzerland)
#39
JOURNAL ARTICLE
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee, David Z Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N Benhammou, Martin Wabitsch, Joseph R Pisegna, Ville Männistö, Kirsi H Pietiläinen, Markku Laakso, Janet S Sinsheimer, Minna U Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat accumulation into the liver. METHODS: To identify adipose-based mechanisms and potential serum biomarker candidates (SBCs) for NAFLD, we utilise dual-tissue RNA-sequencing (RNA-seq) data in adipose tissue and liver, paired with histology-based NAFLD diagnosis, from the same individuals in a cohort of obese individuals...
June 2023: EBioMedicine
#40
Barbara Stussman, Brice Calco, Gina Norato, Angelique Gavin, Snigdha Chigurupati, Avindra Nath, Brian Walitt
BACKGROUND: A central feature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is post exertional malaise (PEM), which is an acute worsening of symptoms after a physical, emotional and/or mental exertion. PEM is also a feature of Long COVID. Dynamic measures of PEM have historically included scaled questionnaires which have not been validated in ME/CFS. To enhance our understanding of PEM and how best to measure it, we conducted semi-structured qualitative interviews (QIs) at the same intervals as Visual Analog Scale (VAS) measures after a Cardiopulmonary Exercise Test (CPET)...
April 26, 2023: medRxiv
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
