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Hemorrhoidal disease

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https://www.readbyqxmd.com/read/29432419/an-efficient-bayesian-meta-analysis-approach-for-studying-cross-phenotype-genetic-associations
#1
Arunabha Majumdar, Tanushree Haldar, Sourabh Bhattacharya, John S Witte
Simultaneous analysis of genetic associations with multiple phenotypes may reveal shared genetic susceptibility across traits (pleiotropy). For a locus exhibiting overall pleiotropy, it is important to identify which specific traits underlie this association. We propose a Bayesian meta-analysis approach (termed CPBayes) that uses summary-level data across multiple phenotypes to simultaneously measure the evidence of aggregate-level pleiotropic association and estimate an optimal subset of traits associated with the risk locus...
February 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29431977/hemorrhoids-diagnosis-and-treatment-options
#2
Timothy Mott, Kelly Latimer, Chad Edwards
Many Americans between 45 and 65 years of age experience hemorrhoids. Hemorrhoidal size, thrombosis, and location (i.e., proximal or distal to the dentate line) determine the extent of pain or discomfort. The history and physical examination must assess for risk factors and clinical signs indicating more concerning disease processes. Internal hemorrhoids are traditionally graded from I to IV based on the extent of prolapse. Other factors such as degree of discomfort, bleeding, comorbidities, and patient preference should help determine the order in which treatments are pursued...
February 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29228790/an-evidence-based-study-on-medicinal-plants-for-hemorrhoids-in-medieval-persia
#3
Mohammad Hashem Hashempur, Fatemeh Khademi, Maryam Rahmanifard, Mohammad M Zarshenas
Hemorrhoids is one of the most common gastrointestinal diseases. There are several therapeutic options associated with some complications. Therefore, researchers look for traditional medicines as a potential resource for introduction of new natural drugs. The current study reports an evidence-based review of herbal remedies for hemorrhoids in traditional Persian medicine. A comprehensive survey about hemorrhoids on the most important manuscripts of traditional Persian medicine was done. Then, scientific data banks were searched for possible related properties of each herb in the conventional medicine...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29186745/-laserhemorrhoidoplasty-with-1470%C3%A2-nm-diode-laser-in-the-treatment-of-second-to-fourth-degree-hemorrhoidal-disease-a-cohort-study-with-497-patients
#4
Guido Weyand, Claudia Susanne Theis, Aboubacar Nzambi Fofana, Felix Rüdiger, Thomas Gehrke
Background Laser haemorrhoidoplasty (LHP) with the 1470 nm diode laser in minimally invasive surgery for advanced haemorrhoid disease has been studied with respect to clinical variables, such as pain and complications, and intraoperative characteristics such as mucopexia, number of treated knots and energy consumed per patient. The study also included patient satisfaction, symptom relevance and cost effectiveness. Patients and Methods Between November 2010 and November 2016, 497 patients (age 55 ± 14 years) were submitted to laser haemorrhoidoplasty with a 1470 nm diode laser in the centre for minimally invasive proctology in Siegen District Hospital...
November 29, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29170839/transanal-hemorrhoidal-dearterialization-thd-for-hemorrhoidal-disease-a-single-center-study-on-1000-consecutive-cases-and-a-review-of-the-literature
#5
Carlo Ratto, Paola Campennì, Francesco Papeo, Lorenza Donisi, Francesco Litta, Angelo Parello
BACKGROUND: The transanal hemorrhoidal dearterialization (THD) Doppler procedure is a minimally invasive technique to treat symptomatic hemorrhoids. The aim of the study was to assess the clinical efficacy and the satisfaction of patients in a large series treated with THD and to review the relevant literature. METHODS: In this retrospective, single-institution, study consecutive patients with grade 2, 3, or 4 hemorrhoidal disease were treated with the THD Doppler procedure...
December 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29154802/microrna-profiling-in-mda-mb-231-human-breast-cancer-cell-exposed-to-the-phaleria-macrocarpa-boerl-fruit-ethyl-acetate-fraction-pmeaf-through-iilumina-hi-seq-technologies-and-various-in-silico-bioinformatics-tools
#6
Nowroji Kavitha, Soundararajan Vijayarathna, Shanmugapriya, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Vasu Punj, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a famous traditional medicinal plant which exhibited cytotoxicity against various cancerous cells. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and heart disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: Recent studies have demonstrated a potent anticancer potential of P...
November 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29131098/implementation-of-a-new-high-volume-circular-stapler-in-stapled-anopexy-for-hemorrhoidal-disease-is-patient-s-short-term-outcome-affected-by-a-higher-volume-of-resected-tissue
#7
Brechtje A Grotenhuis, Joost Nonner, Eelco J R de Graaf, Pascal G Doornebosch
BACKGROUND: Stapled anopexy is a safe technique for the treatment of hemorrhoids but carries a higher risk of recurrence, which might be caused due to the limited volume of resected tissue. In this study, we investigated the introduction of a high-volume circular stapling device; in particular whether an increased amount of resected tissue could affect patients' short-term postoperative outcome. METHODS: Between 2011 and 2015, stapled anopexy was performed for hemorrhoids and/or anal prolapse in 141 patients (n = 25 conventional PPH-3©-stapler versus n = 116 high-volume CHEX©-stapler)...
November 2, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29124622/medicinal-plants-with-antithrombotic-property-in-persian-medicine-a-mechanistic-review
#8
REVIEW
Zahra Memariani, Reihaneh Moeini, Shokooh Sadat Hamedi, Narjes Gorji, Seyyed Ali Mozaffarpur
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties...
November 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29076869/hemorrhoids-what-are-the-options-in-2018
#9
Danny O Jacobs
PURPOSE OF REVIEW: Efforts continue to improve the treatment of patients with symptomatic hemorrhoidal disease by interventions designed to improve efficiency and effectiveness, including by reducing intraoperative and postoperative pain, decreasing operating times, minimizing blood loss and controlling symptoms and recurrence rates. Simultaneously, there are also renewed efforts to minimize the number of patients who will require procedural intervention by focusing on conservative measures that encourage better bowel regulation and habits...
January 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29071068/the-ligament-of-parks-as-a-key-anatomical-structure-for-safer-hemorrhoidectomy-anatomic-study-and-a-simple-surgical-note
#10
Menelaos Zoulamoglou, Ioannis Kaklamanos, Maria Zarokosta, Ioannis Flessas, Vasileios Bonatsos, Theodoros Piperos, Panagiotis Theodoropoulos, Georgia Barla, Ioanna Stathopoulou, Theodoros Mariolis-Sapsakos
Hemorrhoids are a common anal disorder which affects both men and women of all ages. One out of ten patients with hemorrhoidal disease, requires surgical treatment. Unfortunately though, hemorrhoidectomy is closely related to complications that can be present early or late postoperatively. In the present manuscript, the safe surgical technique which emphasizes to the identification of the key anatomical structure of the ligament of Parks (Trietz's muscle) is adequately described. A total of 200 patients with grades III and IV hemorrhoids, underwent Milligan-Morgan or Ferguson's hemorrhoidectomy...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29051401/symptomatic-pile-tailored-procedure-a-new-perspective-for-hemorrhoidal-disease-treatment
#11
Claudio Elbetti, Iacopo Giani, Eugenio Novelli, Jacopo Martellucci, Francesco Feroci
AIM: Aim of the present paper was to evaluate the role of tailored different single pile treatment in the clinical outcome of hemorrhoids. MATERIAL OF STUDY: The surgical strategy considered to treat only pathological piles with different procedure according to each pathological Goligher's degree, presence of fibrous, inelastic redundant internal pile(F) and presence of external pathological pile (external pile congestion or subversion of dental line (E) and skin tag not tolerated from the patient (S))...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28944332/the-whitehead-operation-procedure-is-it-a-useful-technique
#12
Kenan Erzurumlu, Kağan Karabulut, Gökhan Selçuk Özbalcı, İsmail Alper Tarım, Gökhan Lap, Bülent Güngör
OBJECTIVE: Hemorrhoidal disease is a very common entity in the general population; however, the therapeutic approaches to hemorrhoids remain controversial. The choice of treatment method depends on the grade of the hemorrhoid as well as the experience of the surgeon. The Whitehead hemorrhoidectomy procedure is often applied for grade IV hemorrhoids. MATERIAL AND METHODS: We studied 49 patients who underwent surgery between December 1982 and January 2013. The indications for the Whitehead procedure in all patients were grade IV hemorrhoidal disease...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/28943492/comparison-of-clinical-outcomes-of-multi-point-umbrella-suturing-and-single-purse-suturing-with-two-point-traction-after-procedure-for-prolapse-and-hemorrhoids-pph-surgery
#13
Huiyong Jiang, Xiuyan Hao, Ying Xin, Youzhen Pan
OBJECTIVES: To compare the clinical outcomes of multipoint umbrella suture and single-purse suture with two-point traction after procedure for prolapse and hemorrhoids surgery (PPH) for the treatment of mixed hemorrhoids. METHODS: Ninety patients were randomly divided into a PPH plus single-purse suture group (Group A) and a PPH plus multipoint umbrella suture (Group B). All operations were performed by an experienced surgeon. Operation time, width of the specimen, hemorrhoids retraction extent, postoperative pain, postoperative bleeding, and length of hospitalization were recorded and compared...
November 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28932913/a-prospective-randomized-controlled-trial-evaluating-the-short-term-outcomes-of-transanal-hemorrhoidal-dearterialization-versus-tissue-selecting-technique
#14
A L H Leung, T P P Cheung, K Tung, Y P Tsang, H Cheung, C W Lau, C N Tang
BACKGROUND: Tissue-selecting technique (TST) is a novel stapled hemorrhoidectomy technique which targets the hemorrhoids, leaving uninvolved mucosal bridges intact and avoiding circumferential circular stapling. The aim of this study was to compare the short-term outcomes of TST and transanal hemorrhoidal dearterialization (THD). METHODS: Patients presenting with symptomatic hemorrhoids were recruited. Patients were randomized into two groups: (1) TST and (2) THD...
September 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28919630/deep-vein-thrombosis-in-a-post-coronary-artery-bypass-grafting-patient-successful-conservative-management
#15
S H Sarker, A K Miraj, M A Hossain, M Aftabuddin
Deep vein thrombosis is an alarming medical emergency. Deep vein thrombosis or deep venous thrombosis (DVT) is the formation of a blood clot (thrombus) within a deep vein predominantly in the legs. Post-Coronary Artery Bypass Grafting deep vein thrombosis is a very rare medical condition relatively in Asian. Approximately 80% of deep vein thrombosis (DVTs) is clinically asymptomatic, 20% of those that actually demonstrate signs and symptoms can be easily confused with symptoms of other commonly presenting musculoskeletal disorders...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28890058/reversal-of-acute-mesenteric-ischemia-by-salvation-of-the-meandering-mesenteric-artery-with-stenting-of-the-left-internal-iliac%C3%A2-artery
#16
Thomas Kotsis, Panagitsa Christoforou, Constantinos Nastos, Achilles Chatziioannou, Theodosios Theodosopoulos
The presence of the meandering mesenteric artery, which is a nonconstant tortuous arterial component unifying the peripheral intestinal circulation, is evidence of chronic occlusive disease of the main intestinal arteries. This collateral intestinal arterial pathway, when present, must be preserved in any abdominal intervention, as it is often the only remaining arterial supply of the intestine; its ligation can be accompanied by intestinal ischemia. We present herein, the case of a 42-year-old man, heavy smoker, who had chronic mesenteric ischemia without particular clinical manifestations till the hospitalization for acute myocardial infarction for which he underwent balloon angioplasty and stenting of the left circumflex coronary artery...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28884323/-proctology-for-internists
#17
J Feisthammel, J Mössner
In proctology patients can often be helped with very little effort. With knowledge of the most common disease symptoms the treating physician can in many cases correctly recognize the cause of the complaints and initiate the appropriate therapy or arrange referral to a proctological institution. This article aims to briefly and succinctly present the most common diseases in proctology (e.g. mariscae, hemorrhoids, anal fissures, perianal venous thrombosis, abscesses and fistulas, condyloma acuminatum and anal carcinoma) and to provide the treating internist, even outside of gastroenterology, assistance with the management of proctological symptoms...
October 2017: Der Internist
https://www.readbyqxmd.com/read/28873483/a-rare-case-of-amelanotic-anorectal-melanoma
#18
Nicole A Negbenebor, Edward Feller
We report an exceedingly rare case of amelanotic anorectal melanoma misdiagnosed as hemorrhoids. A 74-year-old man presented with a week's history of "blood on toilet tissue" without bowel complaints or history of cutaneous melanoma. Skin evaluation was normal. Rectal exam was negative for blood, but revealed an anal nodule, interpreted as a hemorrhoid. Hemoglobin was normal; bleeding persisted. After one month, colonoscopy detected a non-pigmented anal lesion. Biopsy showed melanoma. Noncutaneous mucosal melanoma represents 0...
September 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28872683/phytochemistry-and-pharmacological-potential-of-cassia-absus-a-review
#19
REVIEW
Saeed Ahmad, Ayesha Hassan, Waheed Mumtaz Abbasi, Tayyeba Rehman
OBJECTIVES: Cassia absus is a plant of the family fabaceae with Ayurvedic ethnomedical records. It is used in traditional medicine for the treatment of bronchitis, asthma, cough, conjunctivitis, leucoderma, renal and hepatic diseases, constipation, tumors, venereal ulcer, headache, hemorrhoids and wound healing. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its use. This review aims to summarize reported pharmacognosy, traditional uses, phytochemistry and pharmacological potential of C...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28871380/mri-of-anal-canal-common-anal-and-perianal-disorders-beyond-fistulas-part-2
#20
REVIEW
Ayşe Erden
A broad spectrum of disease, from benign processes to life-threatening pathologies, can cause anal pain. MR imaging (MRI) has become increasingly widely used method over the past two decades for the evaluation of individuals with anorectal symptoms. Although imaging is rarely necessary to determine the etiology of the majority of cases, MRI is particularly useful as a noninvasive method of excluding severe neoplastic conditions. In this article, MRI findings of a number of pathologies such as anal and perianal neoplasms, hemorrhoidal disease, arteriovenous malformation of the perianal region, and anal sphincter lesions (defects, scarring, atrophy) which may lead to fecal incontinence are presented...
September 4, 2017: Abdominal Radiology
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