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https://www.readbyqxmd.com/read/28367713/src-syk-targeted-anti-inflammatory-actions-of-triterpenoidal-saponins-from-gac-momordica-cochinchinensis-seeds
#1
Jae Sik Yu, Jun Ho Kim, Seulah Lee, Kiwon Jung, Ki Hyun Kim, Jae Youl Cho
Momordica cochinchinensis Spreng (family Cucurbitaceae), also known as gac, or red melon, is an edible Southeast Asian fruit valued for its nutritional and medicinal properties. Specifically, Momordicae Semen, the seeds of the gac fruit, is used in traditional Chinese medicine to treat boils, rheumatic pain, muscle spasm, hemorrhoids, and hemangiomas. In this study, a chemical investigation into a gac seed ethanol (EtOH) extract resulted in the identification of three triterpenoidal saponins (1-3), which were investigated for their anti-inflammatory effects...
April 2, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28367179/comparison-of-two-procedures-for-symptomatic-hemorrhoidal-disease-ligation-under-vision-and-ferguson-hemorrhoidectomy-a-retrospective-cohort-study
#2
Hakan Demir, Kerem Karaman, Metin Ercan, Havva Belma Kocer, Fehmi Celebi
OBJECTIVE: To compare Ligation under Vision (LUV) with Ferguson Hemorrhoidectomy (FH) in patients with Grade II, III and IV hemorrhoidal diseases according to their postoperative outcomes. METHODS: Between July 2008 and August 2014, 155 patients underwent FH and 120 patients LUV, in Sakarya University Teaching and Research Hospital. Our retrospective analysis focuses on postoperative complications, postoperative pain and rate of recurrence. In LUV procedure, submucosal tissue of the hemorrhoidal pile base was transfixed using absorbable sutures under direct vision through anoscope in the Jackknife position...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28365952/cell-free-dna-as-biomarker-and-source-for-mutation-detection-in-primary-colorectal-cancer
#3
Aleksandra Nikolic, Marina Vlajnic, Momcilo Ristanovic, Jelena Petrovic, Ivan Dimitrijevic, Zoran Krivokapic, Dragica Radojkovic
PURPOSE: To analyze if cell-free (cf)DNA levels and the presence of KRAS and BRAF mutations in serum could be used as diagnostic biomarkers in patients with primary colorectal cancer (CRC). METHODS: This study included 92 individuals who were operated due to primary CRC (N=52;study group) and to hemorrhoids (N=40;control group). Serum cfDNA levels were measured with real-time PCR (RT-PCR) using PicoGreen dsDNA quantitation reagent. Colorectal tissue and related blood and serum samples taken at the time of surgery were subjected to DNA extraction and analysis of KRAS and BRAF mutations based on multiplex SNaPshot assay and DNA sequencing...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28334584/delayed-workup-of-rectal-bleeding-in-adult-primary-care-examining-process-of-care-failures
#4
Saul N Weingart, Elena M Stoffel, Daniel C Chung, Thomas D Sequist, Ruth I Lederman, Stephen R Pelletier, Helen M Shields
BACKGROUND: Although delayed colorectal cancer diagnoses figure prominently in medical malpractice claims, little is known about the quality of primary care clinicians' workup of rectal bleeding. METHODS: In this study, 438 patients were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for rectal bleeding, hemorrhoids, and blood in the stool at 10 Boston adult primary care practices. Following nurse chart abstraction, physician reviewers assessed the overall quality of care and key care processes...
January 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28272246/association-of-chronic-obstructive-pulmonary-disease-and-hemorrhoids-a-nationwide-cohort-study
#5
Lih-Hwa Lin, Justin Ji-Yuen Siu, Po-Chi Liao, Jen-Huai Chiang, Pei-Chi Chou, Huey-Yi Chen, Tsung-Jung Ho, Ming-Yen Tsai, Yung-Hsiang Chen, Wen-Chi Chen
According to traditional Chinese medicine (TCM) theory, a specific physiological and pathological relationship exists between the lungs and the large intestine. The aim of this study is to delineate the association of chronic obstructive pulmonary disease (COPD) and hemorrhoids in order to verify the "interior-exterior" relationship between the lungs and the large intestine. A retrospective cohort study is conceived from the National Health Insurance Research Database, Taiwan. The 2 samples (COPD cohort and non-COPD cohort) were selected from the 2000 to 2003 beneficiaries of the NHI, representing patients age 20 and older in Taiwan, with the follow-up ending on December 31, 2011...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28270879/anal-neuroendocrine-tumor-masquerading-as-external-hemorrhoids-a-case-report
#6
Muhammad Khan, Ahmed Dirweesh, Chikezie Alvarez, Herbert Conaway, Robert Moser
Neuroendocrine tumors in gastrointestinal (GI) tract are a rare source of GI malignancy with an estimated incidence of 2.5 - 5 per 100,000 people per year and the prevalence of 35 per 100,000. In the GI tract, they are located in decreasing order of frequency in appendix, ileum, rectum, stomach, and colon. Those found in the anal region represent just 1% of all malignancies of the anal canal. Their clinical presentation can be widely varying, sometimes being found incidentally with metastatic disease and an unknown primary source...
February 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28268046/hemorrhoid-is-associated-with-increased-risk-of-peripheral-artery-occlusive-disease-a-nationwide-cohort-study
#7
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND: This study was conducted to evaluate the association between hemorrhoid and risk of incident peripheral artery occlusive disease (PAOD). METHODS: Using the Taiwanese Longitudinal Health Insurance Database 2000, we compared the incident PAOD risk between the hemorrhoid and the non-hemorrhoid cohorts. Both of these cohorts were followed up from the index date until the date of PAOD diagnosis, withdrawal from the National Health Insurance program, or the end of 2011...
March 3, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28263848/phaleria-macrocarpa-boerl-fruit-induce-g0-g1-and-g2-m-cell-cycle-arrest-and-apoptosis-through-mitochondria-mediated-pathway-in-mda-mb-231-human-breast-cancer-cell
#8
Nowroji Kavitha, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a well-known folk medicinal plant in Indonesia. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and hearth disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: The purpose of this study was to determine the in situ cytotoxicity effect P. macrocarpa fruit ethyl acetate fraction (PMEAF) and the underlying molecular mechanism of cell death...
March 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28163851/a-systematic-review-of-the-relationship-between-dystemprament-sue-mizaj-and-treatments-and-management-of-diseases-ilaj-and-eslah-e-mizaj
#9
REVIEW
Sepide Miraj, Samira Alesaeidi, Sara Kiani
BACKGROUND: Temperament refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for diseases as well as special types of management (avoidance). OBJECTIVE: The aim of this study was to overview the relationship between dystemprament and treatment and management of diseases. METHODS: A computerized search of published articles was performed using PubMed, Scopus, Web of Science, and Medline databases as well as local sources from 1965 to 2016...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28065527/iron-deficiency-anemia-despite-effective-gluten-free-diet-in-celiac-disease-diagnostic-role-of-small-bowel-capsule-endoscopy
#10
Konstantinos Efthymakis, Angelo Milano, Francesco Laterza, Mariaelena Serio, Matteo Neri
BACKGROUND & AIM: Iron deficiency anemia (IDA) is associated with celiac disease (CD). Although gluten-free diet (GFD) is an efficient treatment for CD, IDA remains an occasional finding during follow-up and correlates to inadequate gluten exclusion. Little is known regarding persistent IDA despite effective GFD. We aimed to evaluate the role of small bowel capsule endoscopy (SBCE) in this setting. METHODS: We prospectively included consecutive patients undergoing GFD for ≥24 months with persistent concomitant IDA...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27960130/is-the-severe-pain-after-milligan-morgan-hemorrhoidectomy-still-currently-remaining-a-major-postoperative-problem-despite-being-one-of-the-oldest-surgical-techniques-described-a-case-series-of-117-consecutive-patients
#11
Adrian Medina-Gallardo, Yuhamy Curbelo-Peña, Xavier De Castro, Pere Roura-Poch, Josep Roca-Closa, Enric De Caralt-Mestres
INTRODUCTION: Surgery is the only curative method of hemorrhoidal disease. Currently the Milligan-Morgan hemorrhoidectomy is still considered the "gold standard", since it is the best performing technique. However, postoperative pain remains a major problem. We analize the postoperative analgesic requirements for this procedure in 117 patients. PRESENTATION OF CASES: Between 2012 and 2013, 117 consecutive patients undergoing Milligan-Morgan hemorroidectomy, with an analysis of sex, age, total vascular anal cushions removed, hospital stay, complications, and relation with postoperative analgesic requirements...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27895678/prostate-brachytherapy-in-ghana-our-initial-experience
#12
James Edward Mensah, Joel Yarney, Verna Vanderpuye, Evans Akpakli, Samuel Tagoe, Evans Sasu
PURPOSE: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. MATERIAL AND METHODS: A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27865796/bletilla-striata-medicinal-uses-phytochemistry-and-pharmacological-activities
#13
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Zefeng Zhao, Linhong Huang, Hao Guo, Xiaohui Zheng
ETHNOPHARMACOLOGICAL RELEVANCE: Bletilla striata (Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: ), not only has been widely used for the treatment of hematemesis, hemoptysis, and traumatic bleeding due to the efficacy of arresting bleeding with astringent action, but also has been applied topically to overcome ulcers, sores, swellings, and chapped skin due to the efficacy of dispersing swelling and promoting tissue regeneration. Additional medical applications include the treatment of tuberculosis, malignant ulcers, hemorrhoids, anthrax, eye diseases, and silicosis...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27845307/laparoscopic-abdomino-perineal-resection-for-patients-with-anorectal-malignant-melanoma-a-report-of-4-cases
#14
Jun Han, Chuanbing Shi, Xiaogang Dong, Jie Wang, Hao Wen, Baolin Wang, Zhenyu He
Anorectal malignant melanoma is a very rare but lethal disease. Patients with anorectal malignant melanoma commonly complain for changes in bowel habits and rectal bleeding. Therefore, anorectal malignant melanoma is often misdiagnosed as hemorrhoids, polyp or rectal cancer. Surgery is the mainstay of treatment for patients with anorectal malignant melanoma. However, whether abdominoperineal resection or wide local excision is the most appropriate surgical approach is still a controversial issue. Recently, with the great development of laparoscopic techniques, more and more operations can be performed by laparoscopic techniques...
September 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27819645/supradentate-transmucosal-hemorrhoidopexy-original-technical-variant
#15
Ștefan Voiculescu, Elena Gabriela Voiculescu, Răzvan Scăunaşu, Cristian Bălălău
Symptomatic hemorhoidal disease is a serious issue affecting the quality of life. The multiplicity of current interventional procedures reflects the failure of covering all pathological aspects, thus justifying the quest for other operative solutions. Any new operative procedure is challenged by the need for broad applicability and less invasive attributes and should fit inside the frame of reasonable costs, fair efficacy, low morbidity and recurrence rate based on a procedural technique that is simple enough, reproducible and easy-tolearn...
2016: Chirurgia
https://www.readbyqxmd.com/read/27813396/stapled-anopexy-versus-transanal-hemorrhoidal-dearterialization-for-hemorrhoidal-disease-a-three-year-follow-up-from-a-randomized-study
#16
Marco Venturi, Giovanni Salamina, Contardo Vergani
BACKGROUND: This randomized study compared the medium-term results of stapled anopexy (SA) and transanal hemorrhoidal dearterialization with anopexy (THD) in 4 homogeneous groups of patients, 2 with third- and 2 with fourth-degree hemorrhoids. METHODS: Forty patients with third-degree and 30 with fourth-degree hemorrhoids were randomly submitted to SA (N.=20+15) and THD (N.=20+15), respectively. Clinical controls were done every 6 months from 1 to 42 months after the operation, with incidence of recurrent hemorrhoids as primary outcome measure...
December 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27771095/transanal-hemorrhoid-dearterialization-is-a-safe-and-effective-outpatient-procedure-for-the-treatment-of-hemorrhoidal-disease
#17
Zoran Bjelanovic, Miroljub Draskovic, Milic Veljovic, Ivan Lekovic, Menelaos Karanikolas, Dusica Stamenkovic
INTRODUCTION: This prospective, observational study evaluated transanal dearterialization (THD) efficacy and safety in grade 2-4 hemorrhoids (HD). METHODS: THD was performed under sedation-locoregional anesthesia in 402 outpatients. Patients had follow-up evaluation 3 days, 2 weeks, 1, 6 and 12 months postoperatively. Postoperative complications and recurrence of symptoms at 12 months were analyzed. The relationship between the learning curve and the number of postoperative complications was studied...
December 2016: Cirugía Española
https://www.readbyqxmd.com/read/27760964/-a-case-of-early-anal-canal-cancer-with-pagetoid-spread-with-different-antitumor-effects-of-chemotherapy-on-different-metastatic-sites
#18
Kazuhiko Yoshimatsu, Gakuji Osawa, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Akiko Sakuma, Masaya Satake, Yasufumi Yamada, Shinichi Asaka, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
A 78-year-old man visited our hospital with a prolapsed hemorrhoid. He was referred to the dermatology unit due to the thickness and redness of the perianal skin. He was diagnosed as having extra mammary Paget's disease by skin biopsy. After a biopsy of the anal polyp was performed to investigate the primary site, he was diagnosed with early anal canal cancer with Pagetoid spread and underwent a radical operation. Abdominoperineal resection with skin(D2 prx D3 lymphadenectomy) was performed with perineal reconstruction using a gracilis muscle graft...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760093/-safety-of-use-of-micronized-diosmin-at-daily-doses-up-to-2000-mg-per-day
#19
Agnieszka Staniewska
Formulations of micronized diosmin (MPFF) are widely used in the treatment of chronic venous disease, hemorrhoidal disease and other indications. The usual recommended dose of micronized diosmin is 1000 mg once daily. Numerous studies confirm the superior efficacy and safety of higher doses of diosmin up to 2000 mg per day in a few months therapy. AIM: The aim of the study was to observe the efficacy and safety of micronized diosmine used in a daily dose of 1000 and 2000 mg for 4 months...
October 19, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27759778/long-term-results-after-stapled-hemorrhoidopexy-alone-and-complemented-by-excisional-hemorrhoidectomy-a-retrospective-cohort-study
#20
COMPARATIVE STUDY
Sergio Eduardo Alonso Araujo, Lucas de Araujo Horcel, Victor Edmond Seid, Alexandre Bruno Bertoncini, Sidney Klajner
Background: Stapled hemorrhoidopexy is associated with less postoperative pain and faster recovery. However, it may be associated with a greater risk of symptomatic recurrence. We hypothesized that undertaking a limited surgical excision of hemorrhoid disease after stapling may be a valid approach for selected patients. Aim: To compare long-term results after stapled hemorrhoidopexy with and without complementation with closed excisional technique. Method: In a retrospective uni-institutional cohort study, sixty-five (29 men) patients underwent stapled hemorrhoidopexy and 21 (13 men) underwent stapled hemorrhoidopexy with excision...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
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