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Masahiro Hashizume

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https://www.readbyqxmd.com/read/29218768/relationships-between-serum-brain-derived-neurotrophic-factor-concentration-and-parameters-for-health-scores-in-community-dwelling-older-adults
#1
Mitsugu Hachisu, Masahiro Hashizume, Hisashi Kawai, Hirohiko Hirano, Motonaga Kojima, Yoshinori Fujiwara, Shuichi Obuchi, Kazushige Ihara
AIM: Brain-derived neurotrophic factor (BDNF) have been implicated in the progression of neuronal survival, phenotyping differentiation and maintenance of various neurons, as well as neurogenesis. We studied how BDNF affects health parameters of older adults by carrying out a health examination of community-dwelling older adults. METHODS: We measured the serum BDNF concentration of 898 older adults aged 65-84 years who participated in regional health examinations in the Tokyo area and also measured various parameters, such as the thickness of the quadriceps femoris, percentage of body fat, body mass index, grip strength, frequency of walking, and use of sleeping drugs and steroidal anti-inflammatory drugs...
December 8, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29097051/associations-between-mortality-and-prolonged-exposure-to-elevated-particulate-matter-concentrations-in-east-asia
#2
Satbyul Estella Kim, Michelle L Bell, Masahiro Hashizume, Yasushi Honda, Haidong Kan, Ho Kim
Previous epidemiological studies regarding mortality and particulate matter with an aerodynamic diameter of <10μm (PM10) have considered only absolute concentrations of PM10 as a risk factor. However, none have evaluated the durational effect of multi-day periods with high PM10 concentrations. To evaluate the durational effect (i.e., number of days) of high PM10 concentrations on mortality, we collected data regarding 3,662,749 deaths from 28 cities in Japan, South Korea, and China (1993-2009). Exposure was defined as consecutive days with daily PM10 concentrations ≥75μg/m(3)...
January 2018: Environment International
https://www.readbyqxmd.com/read/29089167/mortality-burden-of-diurnal-temperature-range-and-its-temporal-changes-a-multi-country-study
#3
Whanhee Lee, Michelle L Bell, Antonio Gasparrini, Ben G Armstrong, Francesco Sera, Sunghee Hwang, Eric Lavigne, Antonella Zanobetti, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Samuel Osorio, Aurelio Tobias, Ariana Zeka, Patrick G Goodman, Bertil Forsberg, Joacim Rocklöv, Masahiro Hashizume, Yasushi Honda, Yue-Liang Leon Guo, Xerxes Seposo, Do Van Dung, Tran Ngoc Dang, Shilu Tong, Yuming Guo, Ho Kim
Although diurnal temperature range (DTR) is a key index of climate change, few studies have reported the health burden of DTR and its temporal changes at a multi-country scale. Therefore, we assessed the attributable risk fraction of DTR on mortality and its temporal variations in a multi-country data set. We collected time-series data covering mortality and weather variables from 308 cities in 10 countries from 1972 to 2013. The temporal change in DTR-related mortality was estimated for each city with a time-varying distributed lag model...
January 2018: Environment International
https://www.readbyqxmd.com/read/29084393/longer-term-impact-of-high-and-low-temperature-on-mortality-an-international-study-to-clarify-length-of-mortality-displacement
#4
Ben Armstrong, Michelle L Bell, Micheline de Sousa Zanotti Stagliorio Coelho, Yue-Liang Leon Guo, Yuming Guo, Patrick Goodman, Masahiro Hashizume, Yasushi Honda, Ho Kim, Eric Lavigne, Paola Michelozzi, Paulo Hilario Nascimento Saldiva, Joel Schwartz, Matteo Scortichini, Francesco Sera, Aurelio Tobias, Shilu Tong, Chang-Fu Wu, Antonella Zanobetti, Ariana Zeka, Antonio Gasparrini
BACKGROUND: In many places, daily mortality has been shown to increase after days with particularly high or low temperatures, but such daily time-series studies cannot identify whether such increases reflect substantial life shortening or short-term displacement of deaths (harvesting). OBJECTIVES: To clarify this issue, we estimated the association between annual mortality and annual summaries of heat and cold in 278 locations from 12 countries. METHODS: Indices of annual heat and cold were used as predictors in regressions of annual mortality in each location, allowing for trends over time and clustering of annual count anomalies by country and pooling estimates using meta-regression...
October 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29082297/distinct-pathogenesis-in-nonsystemic-vasculitic-neuropathy-and-microscopic-polyangiitis
#5
Mie Takahashi, Haruki Koike, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Atsushi Hashizume, Masahisa Katsuno, Gen Sobue
OBJECTIVE: To investigate the mechanisms of vasculitis in nonsystemic vasculitic neuropathy (NSVN) and microscopic polyangiitis (MPA), focusing on complement- and antineutrophil cytoplasmic antibody (ANCA)-associated pathogenesis. METHODS: Sural nerve biopsy specimens taken from twenty-four patients with NSVN and 37 with MPA-associated neuropathy (MPAN) were examined. Twenty-two patients in the MPAN group tested positive for ANCA. RESULTS: Immunostaining for complement component C3d deposition showed more frequent positive staining of epineurial small vessels in NSVN than in MPAN (p = 0...
November 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28983659/cardiac-and-peripheral-vasomotor-autonomic-functions-in-late-onset-transthyretin-val30met-familial-amyloid-polyneuropathy
#6
Haruki Koike, Tomohiko Nakamura, Atsushi Hashizume, Ryoji Nishi, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Masahisa Katsuno, Gen Sobue
The objective of this study was to systematically investigate cardiac and peripheral vasomotor autonomic functions in late-onset transthyretin Val30Met familial amyloid polyneuropathy (FAP ATTR Val30Met) patients from non-endemic areas. The coefficient of variation of R-R intervals (CVR-R), responses to the Valsalva manoeuvre, head-up tilt test with impedance cardiography, noradrenaline infusion test, and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy were assessed in eight patients. Although only four patients manifested orthostatic hypotension during the head-up tilt test, CVR-R, responses to the Valsalva manoeuvre, and myocardial MIBG uptake indicated a higher prevalence of cardiac sympathetic and parasympathetic dysfunction...
November 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28886602/heat-wave-and-mortality-a-multicountry-multicommunity-study
#7
Yuming Guo, Antonio Gasparrini, Ben G Armstrong, Benjawan Tawatsupa, Aurelio Tobias, Eric Lavigne, Micheline de Sousa Zanotti Stagliorio Coelho, Xiaochuan Pan, Ho Kim, Masahiro Hashizume, Yasushi Honda, Yue-Liang Leon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel D Schwartz, Michelle L Bell, Matteo Scortichini, Paola Michelozzi, Kornwipa Punnasiri, Shanshan Li, Linwei Tian, Samuel David Osorio Garcia, Xerxes Seposo, Ala Overcenco, Ariana Zeka, Patrick Goodman, Tran Ngoc Dang, Do Van Dung, Fatemeh Mayvaneh, Paulo Hilario Nascimento Saldiva, Gail Williams, Shilu Tong
BACKGROUND: Few studies have examined variation in the associations between heat waves and mortality in an international context. OBJECTIVES: We aimed to systematically examine the impacts of heat waves on mortality with lag effects internationally. METHODS: We collected daily data of temperature and mortality from 400 communities in 18 countries/regions and defined 12 types of heat waves by combining community-specific daily mean temperature ≥90th, 92...
August 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28717138/airborne-bacterial-communities-in-three-east-asian-cities-of-china-south-korea-and-japan
#8
Jae Young Lee, Eun Ha Park, Sunghee Lee, GwangPyo Ko, Yasushi Honda, Masahiro Hashizume, Furong Deng, Seung-Muk Yi, Ho Kim
The global diversity of airborne bacteria has not yet been studied, despite its importance in human health and climate change. Here, we focused on the diversity of airborne bacteria and their correlations with meteorological/environmental conditions in China, South Korea, and Japan. Beijing (China) had more diverse airborne bacteria, followed by Seoul (South Korea) and Nagasaki (Japan), and seasonal variations were observed. Beijing and Seoul had more diverse airborne bacteria during the winter, whereas Nagasaki showed greater diversity during the summer...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686555/heat-related-mortality-in-japan-after-the-2011-fukushima-disaster-an-analysis-of-potential-influence-of-reduced-electricity-consumption
#9
Yoonhee Kim, Antonio Gasparrini, Masahiro Hashizume, Yasushi Honda, Chris Fook Sheng Ng, Ben Armstrong
BACKGROUND: In March 2011, the Great East Japan Earthquake devastated several power stations and caused severe electricity shortages. This accident was followed by the implementation of policies to reduce summer electricity consumption in the affected areas, for example, by limiting air-conditioning (AC) use. This provided a natural experimental scenario to investigate if these policies were associated with an increase in heat-related mortality. OBJECTIVES: We examined whether the reduced electricity consumption in warm season modified heat-related mortality from 2008 to 2012...
July 6, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28670335/clinical-features-of-outpatients-with-somatization-symptoms-treated-at-a-japanese-psychosomatic-medicine-clinic
#10
Yuzo Nakamura, Takeaki Takeuchi, Kazuaki Hashimoto, Masahiro Hashizume
BACKGROUND: Somatization is produced due to the summation of psychological factors, irrespective of the presence or absence of physical factors. A group of diseases with severe pain and other disorders exhibit so-called Medically Unexplained Symptoms (MUS), and the characteristics of patients with MUS are largely unexplained. In this paper, the characteristics of a series of new patients with somatization treated in a Japanese university hospital are discussed. METHOD: The subjects were 871 patients who newly visited the Department of Psychosomatic Medicine, Toho University Omori Medical Center between January and December of 2015...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28650648/indian-ocean-dipole-and-cryptosporidiosis-in-australia-short-term-and-nonlinear-associations
#11
Aparna Lal, Masahiro Hashizume, Simon Hales
The Indian Ocean Dipole (IOD) is a global climate phenomenon that influences the spread of human infectious diseases through climate extremes including droughts and floods. The Dipole Mode Index (DMI), which measures the strength of the IOD, is one of the main indicators of rainfall variability across Australia. Using an ecological, time-series approach we examined the short-term and nonlinear relationship between the DMI and weekly cryptosporidiosis reported from 2001 to 2012 across the temperate, subtropical, and tropical climate zones in Australia, controlling for season, long-term trends, and cryptosporidiosis counts from the past week...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28555071/seasonally-lagged-effects-of-climatic-factors-on-malaria-incidence-in-south-africa
#12
Takayoshi Ikeda, Swadhin K Behera, Yushi Morioka, Noboru Minakawa, Masahiro Hashizume, Ataru Tsuzuki, Rajendra Maharaj, Philip Kruger
Globally, malaria cases have drastically dropped in recent years. However, a high incidence of malaria remains in some sub-Saharan African countries. South Africa is mostly malaria-free, but northeastern provinces continue to experience seasonal outbreaks. Here we investigate the association between malaria incidence and spatio-temporal climate variations in Limpopo. First, dominant spatial patterns in malaria incidence anomalies were identified using self-organizing maps. Composite analysis found significant associations among incidence anomalies and climate patterns...
May 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28444109/temporal-changes-in-mortality-related-to-extreme-temperatures-for-15-cities-in-northeast-asia-adaptation-to-heat-and-maladaptation-to-cold
#13
Yeonseung Chung, Heesang Noh, Yasushi Honda, Masahiro Hashizume, Michelle L Bell, Yue-Liang Leon Guo, Ho Kim
Understanding how the temperature-mortality association worldwide changes over time is crucial to addressing questions of human adaptation under climate change. Previous studies investigated the temporal changes in the association over a few discrete time frames or assumed a linear change. Also, most studies focused on attenuation of heat-related mortality and studied the United States or Europe. This research examined continuous temporal changes (potentially nonlinear) in mortality related to extreme temperature (both heat and cold) for 15 cities in Northeast Asia (1972-2009)...
May 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28406248/sensory-defects-and-developmental-delay-among-children-with-congenital-rubella-syndrome
#14
Michiko Toizumi, Giang Thi Huong Nguyen, Hideki Motomura, Thanh Huu Nguyen, Enga Pham, Ken-Ichi Kaneko, Masafumi Uematsu, Hien Anh Thi Nguyen, Duc Anh Dang, Masahiro Hashizume, Lay-Myint Yoshida, Hiroyuki Moriuchi
This study investigated the features of developmental difficulties combined with sensory defects in children with congenital rubella syndrome (CRS). Following a large rubella outbreak in Khanh Hoa Province, Vietnam, in 2011, we enrolled 41 children with CRS from September 2011 through May 2013. Fourteen participants died and six became untraceable by October 2013; the remaining 21 children were followed up from 2013 to 2015. Thirteen and seven participants had hearing and functional ophthalmological impairment, respectively...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28003673/shortening-oblique-osteotomy-with-screw-fixation-for-correction-of-the-lesser-metatarsophalangeal-joints-of-rheumatoid-forefoot
#15
Keiichiro Nishida, Takahiro Machida, Masahiro Horita, Kenzo Hashizume, Ryuichi Nakahara, Yoshihisa Nasu, Hideki Ohashi, Kenta Saiga, Toshifumi Ozaki
The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59...
December 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27893089/photoacoustic-mammography-capable-of-simultaneously-acquiring-photoacoustic-and-ultrasound-images
#16
Yasufumi Asao, Yohei Hashizume, Takahiro Suita, Ken-Ichi Nagae, Kazuhiko Fukutani, Yoshiaki Sudo, Toshikazu Matsushita, Shuichi Kobayashi, Mariko Tokiwa, Iku Yamaga, Elham Fakhrejahani, Masae Torii, Masahiro Kawashima, Masahiro Takada, Shotaro Kanao, Masako Kataoka, Tsuyoshi Shiina, Masakazu Toi
We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis...
November 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27833062/seasonal-analysis-of-the-short-term-effects-of-air-pollution-on-daily-mortality-in-northeast-asia
#17
Satbyul Estella Kim, Yasushi Honda, Masahiro Hashizume, Haidong Kan, Youn-Hee Lim, Hyewon Lee, Clara Tammy Kim, Seung-Muk Yi, Ho Kim
The constituents and concentrations of pollutants, individual exposures, and biologic responses to air pollution may vary by season and meteorological conditions. However, evidence regarding seasonality of the acute effects of air pollution on mortality is limited and inconsistent. Herein, we examined seasonal patterns in the short-term associations of particulate matter (PM) smaller than 10μm (PM10) with daily mortality in 29 cities of three northeast Asian countries. Stratified time-series models were used to determine whether season altered the effect of PM10 on mortality...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27771246/protective-effects-of-estrogen-against-vascular-calcification-via-estrogen-receptor-%C3%AE-dependent-growth-arrest-specific-gene-6-transactivation
#18
Michiko Nanao-Hamai, Bo-Kyung Son, Tsuyoshi Hashizume, Sumito Ogawa, Masahiro Akishita
Vascular calcification is one of the major complications of cardiovascular disease and is an independent risk factor for myocardial infarction and cardiac death. Postmenopausal women have a higher prevalence of vascular calcification compared with premenopausal women, suggesting protective effects of estrogen (E2). However, the underlying mechanisms of its beneficial effects remain unclear. In the present study, we examined the inhibitory effects of E2 on vascular smooth muscle cell (VSMC) calcification, and found that growth arrest-specific gene 6 (Gas6), a crucial molecule in vascular calcification, is transactivated by estrogen receptor α (ERα) in response to E2...
November 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27746294/molecular-evolution-of-respiratory-syncytial-virus-subgroup-a-genotype-na1-and-on1-attachment-glycoprotein-g-gene-in-central-vietnam
#19
Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, Hien Anh Nguyen, Michiko Toizumi, Hiroyuki Moriuchi, Masahiro Hashizume, Koya Ariyoshi, Duc Anh Dang, Hirokazu Kimura, Lay-Myint Yoshida
We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains...
November 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27628555/-a-case-of-her2-positive-stage-iv-advanced-gastric-cancer-treated-with-chemotherapy-combined-with-trastuzumab
#20
Kai Takaya, Ryosuke Takahashi, Satoru Honma, Shinichiro Horii, Hirokazu Takahashi, Motohisa Hagiwara, Masahiro Chin, Eiji Hashizume
We report a case of human epidermal growth factor receptor(HER)2 positive stage IV advanced gastric cancer successfully treated with chemotherapy combined with trastuzumab. A 50-year-old man was diagnosed with type 3 gastric cancer complicated by liver and lymph node metastases. Owing to a HER2 immunohistochemistry tumor score of 3+, we initiated capecitabine plus CDDP plus trastuzumab chemotherapy. After 6 chemotherapy courses, computed tomography showed the liver metastasis had disappeared and the paraaortic lymph nodes had shrunk...
September 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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