Kaiwen Bao, Yanhui Ma, Yuan Li, Xilin Shen, Jiao Zhao, Shanshan Tian, Chunyong Zhang, Can Liang, Ziyan Zhao, Ying Yang, Kai Zhang, Na Yang, Fei-Long Meng, Jihui Hao, Jie Yang, Tao Liu, Zhi Yao, Ding Ai, Lei Shi
Appropriate DNA end synapsis, regulated by core components of the synaptic complex including KU70-KU80, LIG4, XRCC4, and XLF, is central to non-homologous end joining (NHEJ) repair of chromatinized DNA double-strand breaks (DSBs). However, it remains enigmatic whether chromatin modifications can influence the formation of NHEJ synaptic complex at DNA ends, and if so, how this is achieved. Here, we report that the mitotic deacetylase complex (MiDAC) serves as a key regulator of DNA end synapsis during NHEJ repair in mammalian cells...
February 21, 2024: Molecular Cell