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https://www.readbyqxmd.com/read/28631213/the-constitutive-protease-release-by-primary-human-acute-myeloid-leukemia-cells
#1
Maria Honnemyr, Øystein Bruserud, Annette K Brenner
INTRODUCTION: Acute myeloid leukemia (AML) cells show constitutive release of matrix metalloproteases and their inhibitors. We now investigated this constitutive release of protease/protease regulators associated with carcinogenesis (ADAM12, uPA, cystatin B), angiogenesis (serpin E1, uPA, CD147), cancer cell migration (uPA, cystatin C), coagulation (ADAM TS13, serpin C1), inflammation (fetuin A, caspase 1, cystatin C), monocytic differentiation (CFD) or regulation of hematopoiesis (neutrophil elastase)...
June 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28620388/trichinella-spiralis-calreticulin-binds-human-complement-c1q-as-an-immune-evasion-strategy
#2
Limei Zhao, Shuai Shao, Yi Chen, Ximeng Sun, Ran Sun, Jingjing Huang, Bin Zhan, Xinping Zhu
As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood. Here, we identified that T. spiralis calreticulin (Ts-CRT), a Ca(2+)-binding protein, facilitated T. spiralis immune evasion by interacting with the first component of human classical complement pathway, C1q. In the present study, Ts-CRT was found to be expressed on the surface of different developmental stages of T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28614806/review-of-rosai-dorfman-disease-new-insights-into-the-pathogenesis-of-this-rare-disorder
#3
Yanan Cai, Zhangzhen Shi, Yuansong Bai
Rosai-Dorfman disease (RDD) is a rare histiocytosis typically with bilateral painless cervical lymphadenopathy. Laboratory data are nonspecific, and the presence of emperipolesis in large foamy S-100+ CD1a- histiocytes is the prominent histologic feature. The pathogenesis of RDD still remains elusive. According to published studies, we propose that RDD cells might represent intermediate recruiting monocytes with differentiation blockade. Both disturbance of homoeostasis and inherent genomic alterations could contribute to initiation of the disorder through signal transduction...
June 15, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28609832/pembrolizumab-induced-thyroiditis-comprehensive-clinical-review-and-insights-into-underlying-involved-mechanisms
#4
Danae A Delivanis, Michael P Gustafson, Svetlana Bornschlegl, Michele M Merten, Lisa Kottschade, Sarah Withers, Allan B Dietz, Mabel Ryder
Context: Thyroid immune-related adverse events (irAEs) in patients treated with programmed death receptor-1 (PD-1) blockade are increasingly recognized as one of the most common adverse effects. Our aim was to determine the incidence and examine the potential mechanisms of anti-PD-1 induced thyroid irAEs. Design: Single center, retrospective cohort study. Patients and Measurements: We studied 93 patients with advanced cancer (aged 24–82 years; 60% males) who received at least one infusion of pembrolizumab...
May 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28606987/the-fate-and-lifespan-of-human-monocyte-subsets-in-steady-state-and-systemic-inflammation
#5
Amit A Patel, Yan Zhang, James N Fullerton, Lies Boelen, Anthony Rongvaux, Alexander A Maini, Venetia Bigley, Richard A Flavell, Derek W Gilroy, Becca Asquith, Derek Macallan, Simon Yona
In humans, the monocyte pool comprises three subsets (classical, intermediate, and nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, differentiation, and disappearance are critical to understanding both steady-state homeostasis and inflammatory responses. Here, using human in vivo deuterium labeling, we demonstrate that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day. Subsequent labeling of intermediate and nonclassical monocytes is consistent with a model of sequential transition...
June 12, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28604383/pyruvate-controls-the-checkpoint-inhibitor-pd-l1-and-suppresses-t-cell-immunity
#6
Ryu Watanabe, Tsuyoshi Shirai, Hong Namkoong, Hui Zhang, Gerald J Berry, Barbara B Wallis, Benedikt Schaefgen, David G Harrison, Jennifer A Tremmel, John C Giacomini, Jörg J Goronzy, Cornelia M Weyand
Patients with coronary artery disease (CAD) are at high risk for reactivation of the varicella zoster virus (VZV) and development of herpes zoster (HZ). Here, we found that macrophages from patients with CAD actively suppress T cell activation and expansion, leading to defective VZV-specific T cell immunity. Monocyte-derived and plaque-infiltrating macrophages from patients with CAD spontaneously expressed high surface density of the immunoinhibitory ligand programmed death ligand-1 (PD-L1), thereby providing negative signals to programmed death-1+ (PD-1+) T cells...
June 12, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28596372/human-blood-monocyte-subsets-a-new-gating-strategy-defined-using-cell-surface-markers-identified-by-mass-cytometry
#7
Graham D Thomas, Anouk A J Hamers, Catherine Nakao, Paola Marcovecchio, Angela M Taylor, Chantel McSkimming, Anh Tram Nguyen, Coleen A McNamara, Catherine C Hedrick
OBJECTIVE: Human monocyte subsets are defined as classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(+)). Alterations in monocyte subset frequencies are associated with clinical outcomes, including cardiovascular disease, in which circulating intermediate monocytes independently predict cardiovascular events. However, delineating mechanisms of monocyte function is hampered by inconsistent results among studies. APPROACH AND RESULTS: We use cytometry by time-of-flight mass cytometry to profile human monocytes using a panel of 36 cell surface markers...
June 8, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28593077/alteration-in-leukocyte-subsets-and-expressions-of-fc%C3%AE-r-and-complement-receptors-among-female-ragpickers-in-eastern-india
#8
Nandan K Mondal, Shabana Siddique, Madhuchanda Banerjee, Sanghita Roychoudhury, Sayali Mukherjee, Mark S Slaughter, Twisha Lahiri, Manas R Ray
BACKGROUND: There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. METHODS: Seventy-four women ragpickers (median age, 30 years) and 65 age-matched control housemaids were enrolled. Flow cytometry was used to measure leukocyte subsets, and leukocyte expressions of Fcγ receptor I (CD64), FcγRIII (CD16), complement receptor 1 (CD35) and CR3 (CD11b/CD18), and CD14...
June 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28585214/the-interactions-between-kynurenine-folate-methionine-and-pteridine-pathways-in-obesity
#9
Ayse Basak Engin, Atilla Engin
Obesity activates both innate and adaptive immune responses in adipose tissue. Elevated levels of eosinophils with depression of monocyte and neutrophil indicate the deficiencies in the immune system of morbidly obese individuals. Actually, adipose tissue macrophages are functional antigen-presenting cells that promote the proliferation of interferon-gamma (IFN-gamma)-producing CD4+ T cells in adipose tissue of obese subjects. Eventually, diet-induced obesity is associated with the loss of tissue homeostasis and development of type 1 inflammatory responses in visceral adipose tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28583160/differential-expression-of-cathepsin-e-in-transthyretin-amyloidosis-from-neuropathology-to-the-immune-system
#10
Nádia Pereira Gonçalves, João Moreira, Diana Martins, Paulo Vieira, Laura Obici, Giampaolo Merlini, Margarida Saraiva, Maria João Saraiva
BACKGROUND: Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune cell infiltration is observed around pre-fibrillar or fibrillar amyloid deposits, with the underlying mechanism for this phenomenon remaining poorly understood. Cathepsin E (CtsE) is an important intermediate for antigen presentation and chemotaxis, but its role in the pathogenesis of FAP disease remains unknown...
June 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28578934/reprint-of-microrna-profiling-of-human-intermediate-monocytes
#11
Adam M Zawada, Lu Zhang, Insa E Emrich, Kyrill S Rogacev, Nicolas Krezdorn, Björn Rotter, Danilo Fliser, Yvan Devaux, Loems Ziegler-Heitbrock, Gunnar H Heine
Among the three human monocyte subsets, intermediate CD14++CD16+ monocytes have been characterized as particularly proinflammatory cells in experimental studies and as potential biomarkers of cardiovascular risk in clinical cohorts. To further substantiate the distinct role of intermediate monocytes within human monocyte heterogeneity, we assessed subset-specific expression of miRNAs as central epigenetic regulators of gene expression. We hypothesized that intermediate monocytes have a distinct miRNA profile compared to classical and non-classical monocytes...
June 2017: Immunobiology
https://www.readbyqxmd.com/read/28576352/reprint-of-alterations-of-trim21-mrna-expression-during-monocyte-maturation
#12
Marzena Lenart, Magdalena Rutkowska-Zapała, Rafał Szatanek, Kazimierz Węglarczyk, Małgorzata Stec, Karolina Bukowska-Strakova, Anna Gruca, Jarosław Czyż, Maciej Siedlar
Tripartite motif-containing protein 21 (TRIM21) play a dual role in the cytoplasm of the cells where it facilitates destruction of some antibody-coated viruses and some bacteria, and initiates synthesis of proinflammatory cytokines. Macrophages and CD16(+) monocyte subset can particularly participate in a proinflammatory response caused by viral infection, however, the molecular mechanisms underlying these processes are not fully understood. The aim of this study was to determine the level of TRIM21-mRNA expression in monocyte subsets including: classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)) and non-classical (CD14(+)CD16(++)) monocytes, as well as during in vitro differentiation of the isolated monocytes towards dendritic cells or macrophages...
June 2017: Immunobiology
https://www.readbyqxmd.com/read/28570862/monocyte-inflammatory-profile-is-specific-for-individuals-and-associated-with-altered-blood-lipid-levels
#13
Vyoma K Patel, Helen Williams, Stephen C H Li, John P Fletcher, Heather J Medbury
BACKGROUND AND AIMS: Atherogenesis is dependent upon monocyte influx into the vessel wall. In humans, three monocyte subsets exist, the number and function of which are significantly altered in cardiovascular disease (CVD). Whether such alterations arise in individuals with a perturbed lipid profile remains largely unanswered, but is important to delineate, as adoption of a pro-inflammatory state may promote plaque formation. Here, we compared the inflammatory status of monocyte subsets and determined whether monocyte inflammatory changes are evident in individuals with a perturbed lipid profile...
May 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28567553/plasma-levels-of-srankl-and-opg-are-associated-with-atherogenic-cytokines-in-patients-with-intermediate-cardiovascular-risk
#14
Dorette Raaz-Schrauder, Michael G Schrauder, Christian Stumpf, Piotr Lewczuk, Tobias Kilian, Barbara Dietel, Christoph D Garlichs, Christian Schlundt, Stephan Achenbach, Lutz Klinghammer
Osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) are regulators of bone remodeling, but are also considered to play important roles in coronary artery disease (CAD). This study evaluated potential associations of soluble (s) RANKL and OPG with atherosclerosis-relevant cytokines. Blood was collected from 414 individuals who presented to our hospital with intermediate likelihood for CAD for further examination. Plasma concentrations of total sRANKL, OPG, and 20 cytokines were measured using sandwich-type enzyme-linked immunoassays (ELISAs; OPG and sRANKL) and Luminex laser-based fluorescence analysis and correlated with each other...
May 31, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28566492/functional-evidence-for-derivation-of-systemic-histiocytic-neoplasms-from-hematopoietic-stem-progenitor-cells
#15
Benjamin H Durham, Damien Roos-Weil, Claude Baillou, Fleur Cohen-Aubart, Akihide Yoshimi, Makoto Miyara, Matthias Papo, Zofia Hélias-Rodzewicz, Nathalie Terrones, Neval Ozkaya, Ahmet Dogan, Raajit Rampal, Fanny Urbain, Lucie Le Fèvre, Eli L Diamond, Christopher Y Park, Thomas Papo, Frédéric Charlotte, Guy Gorochov, Valérie Taly, Olivier A Bernard, Zahir Amoura, Omar Abdel-Wahab, François M Lemoine, Julien Haroche, Jean-Francois Emile
Langerhans Cell Histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester Disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell-, or monocyte-derived cells in tissues driven by recurrent mutations activating MAP kinase signaling. Although recent data indicate that at least a proportion of LCH and ECD patients have detectable activating kinase mutations in circulating hematopoietic cells and bone marrow-based hematopoietic progenitors, functional evidence of the cell-of-origin of histiocytosis from actual patient materials has long been elusive...
May 31, 2017: Blood
https://www.readbyqxmd.com/read/28566450/monocyte-subtypes-and-the-ccr2-chemokine-receptor-in-cardiovascular-disease
#16
REVIEW
Carolina N França, Maria C O Izar, Marinella N S Hortêncio, Jônatas B do Amaral, Carlos E S Ferreira, Izabela D Tuleta, Francisco A H Fonseca
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14(++)CD16(-)CCR2(++) cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14(++)CD16(+)CCR2(+)) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β)...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28555251/post-resistance-exercise-ingestion-of-milk-protein-attenuates-plasma-tnf%C3%AE-and-tnfr1-expression-on-monocyte-subpopulations
#17
Adam J Wells, Adam R Jajtner, Alyssa N Varanoske, David D Church, Adam M Gonzalez, Jeremy R Townsend, Carleigh H Boone, Kayla M Baker, Kyle S Beyer, Gerald T Mangine, Leonardo P Oliveira, David H Fukuda, Jeffrey R Stout, Jay R Hoffman
Attenuating TNFα/TNFr1 signaling in monocytes has been proposed as a means of mitigating inflammation. The purpose of this study was to examine the effects of a milk protein supplement on TNFα and monocyte TNFr1 expression. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) ingested supplement (SUPP) or placebo (PL) immediately post-exercise in a randomized, cross-over design. Blood samples were obtained at baseline (BL), immediately (IP), 30-min (30P), 1-h (1H), 2-h (2H), and 5-h (5H) post-exercise to assess plasma concentrations of myoglobin; tumor necrosis factor-alpha (TNFα); and expression of tumor necrosis factor receptor 1 (TNFr1) on classical, intermediate, and non-classical monocytes...
May 29, 2017: Amino Acids
https://www.readbyqxmd.com/read/28552694/mesna-2-mercaptoethane-sodium-sulfonate-functions-as-a-regulator-of-myeloperoxidase
#18
Roohi Jeelani, Seyedehameneh Jahanbakhsh, Hamid-Reza Kohan-Ghadr, Mili Thakur, Sana Khan, Sarah R Aldhaheri, Zhe Yang, Peter Andreana, Robert Morris, Husam M Abu-Soud
Myeloperoxidase (MPO), an abundant protein in neutrophils, monocytes, and macrophages, is thought to play a critical role in the pathogenesis of various disorders ranging from cardiovascular diseases to cancer. We show that mesna (2-mercaptoethanesulfonic acid sodium salt), a detoxifying agent, which inhibits side effects of oxazaphosphorine chemotherapy, functions as a potent inhibitor of MPO; modulating its catalytic activity and function. Using rapid kinetic methods, we examined the interactions of mesna with MPO compounds I and II and ferric forms in the presence and absence of chloride (Cl(-)), the preferred substrate of MPO...
May 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28551623/the-immunological-roles-of-periostin-tumor-associated-macrophage-axis-in-development-of-dermatofibrosarcoma-protuberans
#19
Taku Fujimura, Aya Kakizaki, Yota Sato, Kayo Tanita, Sadanori Furudate, Setsuya Aiba
BACKGROUND/AIM: Dermatofibrosarcoma protuberance (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by slow infiltrative growth and a high tendency to recur locally. Periostin is involved in modulating cell function and inducing the production of proinflammatory cytokines, chemokines, and matrix metalloproteinases (MMPs) from tumor-associated macrophages (TAMs) to promote fibrosis and tumor growth. This study aimed to examine the cancer stroma of DFSP, focusing on TAMs-related proteins and MMPs...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28536942/lrrc25-plays-a-key-role-in-all-trans-retinoic-acid-induced-granulocytic-differentiation-as-a-novel-potential-leukocyte-differentiation-antigen
#20
Weili Liu, Ting Li, Pingzhang Wang, Wanchang Liu, Fujun Liu, Xiaoning Mo, Zhengyang Liu, Quansheng Song, Ping Lv, Guorui Ruan, Wenling Han
Leukocyte differentiation antigens (LDAs) play important roles in the immune system, by serving as surface markers and participating in multiple biological activities, such as recognizing pathogens, mediating membrane signals, interacting with other cells or systems, and regulating cell differentiation and activation. Data mining is a powerful tool used to identify novel LDAs from whole genome. LRRC25 (leucine rich repeat-containing 25) was predicted to have a role in the function of myeloid cells by a large-scale "omics" data analysis...
May 23, 2017: Protein & Cell
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