Melanie Schirmer, Martin Stražar, Julian Avila-Pacheco, Daniel F Rojas-Tapias, Eric M Brown, Emily Temple, Amy Deik, Kevin Bullock, Sarah Jeanfavre, Kerry Pierce, Shen Jin, Rachele Invernizzi, Marie-Madlen Pust, Zach Costliow, David R Mack, Anne M Griffiths, Thomas Walters, Brendan M Boyle, Subra Kugathasan, Hera Vlamakis, Jeffrey Hyams, Lee Denson, Clary B Clish, Ramnik J Xavier
Understanding the role of the microbiome in inflammatory diseases requires the identification of microbial effector molecules. We established an approach to link disease-associated microbes to microbial metabolites by integrating paired metagenomics, stool and plasma metabolomics, and culturomics. We identified host-microbial interactions correlated with disease activity, inflammation, and the clinical course of ulcerative colitis (UC) in the Predicting Response to Standardized Colitis Therapy (PROTECT) pediatric inception cohort...
January 4, 2024: Cell Host & Microbe