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https://www.readbyqxmd.com/read/29917326/replacement-and-desmoplastic-histopathological-growth-patterns-a-pilot-study-of-prediction-of-outcome-in-patients-with-uveal-melanoma-liver-metastases
#1
Raymond Barnhill, Peter Vermeulen, Sofie Daelemans, Pieter-Jan van Dam, Sergio Roman-Roman, Vincent Servois, Ilse Hurbain, Sophie Gardrat, Graça Raposa, Nicolas André, Rémi Dendale, Gaëlle Pierron, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
Up to 50% of uveal melanomas (UM) metastasize to the liver within 10 years of diagnosis, and these almost always prove rapidly fatal. Since histopathological growth patterns (HGP) of liver metastases of the replacement and desmoplastic type, particularly from colon and breast carcinoma, may import valuable biological and prognostic information, we have studied HGP in a series of 41 UM liver metastases originating from 41 patients from the period 2006-2017. Twenty patients underwent enucleation while 21 had radiation therapy...
June 19, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29917323/crispr-mediated-genome-editing-and-gene-repression-in-scheffersomyces-stipitis
#2
Mingfeng Cao, Meirong Gao, Deon Ploessl, Cunjiang Song, Zengyi Shao
Scheffersomyces stipitis, renowned for its native xylose-utilizing capacity, has recently demonstrated its potential in producing health-promoting shikimate pathway derivatives. However, its broader application is hampered by the low transformation efficiency and the lack of genetic engineering tools to enable sophisticated genomic manipulations. S. stipitis employees the predominant non-homologous end joining (NHEJ) mechanism for repairing DNA double-strand breaks (DSB), which is less desired due to its incompetence in achieving precise genome editing...
June 19, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29917301/prevalence-and-prognostic-impact-of-non-cardiac-co-morbidities-in-heart-failure-outpatients-with-preserved-and-reduced-ejection-fraction-a-community-based-study
#3
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29917246/protective-effect-of-tadalafil-and-verapamil-on-testicular-function-and-oxidative-stress-after-torsion-detorsion-in-adult-male-rat
#4
Mojtaba Ameli, Mohaddeseh Sadat Hashemi, Maryam Moghimian, Majid Shokoohi
OBJECTIVE: This study used a rat model to investigate the protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion. METHODS AND MATERIALS: Animals were randomly divided into five groups: G1, Sham group; G2, testicular torsion followed by detorsion (TD); G3, testicular torsion/detorsion received 0/4 mg/kg of tadalafil (TDT); G4, testicular torsion/detorsion received 0/1 mg/kg of verapamil (TDV); and G5, testicular torsion/detorsion received 0/1 mg/kg of verapamil and 0/4 mg/kg of tadalafil (TDTV)...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29917211/cardiocerebral-protective-effects-of-dexmedetomidine-as-anesthetic-in-colorectal-cancer-surgery
#5
X-L Yi, J-T Wang, C-Q Chu, Y-X Li, J-H Yin, S-L Liu
OBJECTIVE: To explore the cardiocerebral protective effect of dexmedetomidine as an anesthetic in colorectal cancer surgery. PATIENTS AND METHODS: A total of 246 colorectal cancer patients were enrolled in this retrospective analysis. Those patients were admitted to the Affiliated Hospital of Qingdao University and underwent surgery from July 2014 to July 2016. The patients were divided into observation group and control group according to the anesthetic used in surgery...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917140/predictive-biomarkers-for-endocrine-therapy-retrospective-study-in-tamoxifen-and-exemestane-adjuvant-multinational-team-trial
#6
Antonia K Roseweir, Lindsay Bennett, Ashley Dickson, Kelvin Cheng, Mary-Anne Quintayo, Jane Bayani, Donald C McMillan, Paul G Horgan, Cornelis J H van de Velde, Caroline Seynaeve, Annette Hasenburg, Dirk G Kieback, Christos Markopoulos, Luc Y Dirix, Daniel W Rea, Elizabeth A Mallon, John M S Bartlett, Joanne Edwards
Background: Aromatase inhibitors improve disease-free survival compared with tamoxifen in postmenopausal women with hormone receptor-positive breast cancer. The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial compared exemestane monotherapy with sequential therapy of tamoxifen followed by exemestane. The trial failed to show a statistically significant difference between treatment arms. A robust translational program was established to investigate predictive biomarkers. Methods: A tissue microarray was retrospectively constructed using a subset of patient tissues (n = 4631) from the TEAM trial (n = 9766)...
June 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29916985/impact-of-the-current-versus-the-previous-diagnostic-threshold-on-the-outcome-of-patients-with-borderline-changes-suspicious-for-t-cell-mediated-rejection-diagnosed-on-indication-biopsies
#7
Michael McRae, François Bouchard-Boivin, Stéphanie Béland, Réal Noël, Isabelle Côté, Isabelle Lapointe, Julie Lesage, Eva Latulippe, Julie Riopel, Dominick Santoriello, Syed A Husain, Olivier Désy, Isabelle Houde, Ibrahim Batal, Sacha A De Serres
BACKGROUND: Since the borderline changes suspicious for acute T-cell-mediated rejection (BL) category was broadened, there has been a debate regarding the right threshold for tubulitis (t) and interstitial inflammation (i) scores. METHODS: We studied a first cohort of 111 patients with BL found on an indication biopsy between 2006 and 2016 and compared those with scores of t1i0 (BLt1i0) to those with higher scores (BL≥t1i1). A second cohort of 56 patients with BL was used for external validation...
June 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29916927/laboratory-tests-for-diagnosis-of-chronic-periprosthetic-joint-infection-can-help-predict-outcomes-of-two-stage-exchange
#8
Maureen K Dwyer, Christopher Damsgaard, Jason Wadibia, Gordon Wong, Damien Lazar, Eric Smith, Carl Talmo, Hany Bedair
BACKGROUND: Although 2-stage exchange arthroplasty is the most effective treatment among available strategies for managing chronic periprosthetic joint infection (PJI), rates of its success vary greatly. The purpose of our study was to examine whether objective measurements collected at the time of the diagnosis of PJI could be used to identify patients at risk of failure of 2-stage exchange. METHODS: We identified 205 patients across 4 institutions who underwent 2-stage exchange arthroplasty for the treatment of PJI following total hip or total knee arthroplasty...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916857/serum-lactate-level-accurately-predicts-mortality-in-critically-ill-patients-with-cirrhosis-with-acute-kidney-injury
#9
Dan-Qin Sun, Chen-Fei Zheng, Feng-Bin Lu, Sven Van Poucke, Xiao-Ming Chen, Yong-Ping Chen, Lai Zhang, Ming-Hua Zheng
BACKGROUND AND AIM: Serum lactate levels are routinely measured in critically ill patients with cirrhosis, and hyperlactatemia is a common finding, but its prognostic value remains controversial. Our aim was to examine whether serum lactate level could be used as a predictor of outcome in critically ill patients with cirrhosis (CICP) with acute kidney injury (AKI). PATIENTS AND METHODS: In this study, we included 480 consecutive patients with cirrhosis admitted to ICU, complicated with AKI, and were followed up for 365 days...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29916753/infective-endocarditis-in-western-norway-a-20-year-retrospective-survey
#10
Stina Jordal, Bård Reiakvam Kittang, Pirjo-Riitta Salminen, Geir Egil Eide, Øyvind Kommedal, Øystein Wendelbo, Rune Haaverstad, Haakon Sjursen
BACKGROUND: To investigate epidemiological trends of infective endocarditis (IE) in western Norway a retrospective study was performed. METHODS: Characteristics of 706 IE admissions from 1996 to 2005 and 2006 to 2015 were analysed and compared using the Chi-square test for categorical variables and the t-test for age. Survival was analysed by multiple Cox regression and reported by the hazard ratio (HR). RESULTS: Mean annual incidence rates increased from 4...
June 19, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29916580/-guidelines-for-occupational-exposures-to-mechanical-vibration
#11
Massimo Bovenzi, Marcella Mauro
OBJECTIVES: In this study, the daily exposure action values (EAV) and the daily exposure limit values (ELV) for hand-transmitted vibration (HTV) and whole-body vibration (WBV), established by the EU Directive 2002/44/EC and the Italian Decree 81/2008, and expressed in terms of 8-hr frequency weighted r.m.s. acceleration magnitude, are discussed upon consideration of the findings of experimental and epidemiological studies. METHODS: There is some epidemiological support for the EAV A(8) of 2...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916558/increased-right-atrial-volume-measured-with-cardiac-magnetic-resonance-is-associated-with-worse-clinical-outcome-in-patients-with-pre-capillary-pulmonary-hypertension
#12
Anna Bredfelt, Göran Rådegran, Roger Hesselstrand, Håkan Arheden, Ellen Ostenfeld
AIMS: Pre-capillary pulmonary hypertension (PHpre-cap ) has a poor prognosis, especially when caused by pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-PAH). Whether cardiac magnetic resonance (CMR)-based quantification of atrial volumes in PHpre-cap is beneficial in risk assessment is unknown. The aims were to investigate if (i) atrial volumes using CMR are associated with death or lung transplantation in PHpre-cap , (ii) atrial volumes differ among four unmatched major PHpre-cap subgroups, and (iii) atrial volumes differ between SSc-PAH and idiopathic/familial PAH (IPAH/FPAH) when matched for pulmonary vascular resistance (PVR)...
June 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29916140/statin-use-is-not-associated-with-future-long-term-care-admission-extended-follow-up-of-two-randomised-controlled-trials
#13
Jennifer K Burton, Richard Papworth, Caroline Haig, Colin McCowan, Ian Ford, David J Stott, Terence J Quinn
BACKGROUND: Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe associations between long-term care admission and other clinical and demographic factors. METHODS: We used extended follow-up of two randomised trial populations, using national data to assign the long-term care admission outcome, and included individuals screened or recruited to two large randomised trials of pravastatin 40 mg daily-the West of Scotland Coronary Prevention Study (WOSCOPS) and the pravastatin in elderly individuals at risk of vascular disease (PROSPER) study...
June 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29915957/transcriptional-analysis-of-immune-genes-in-epstein-barr-virus-associated-gastric-cancer-and-association-with-clinical-outcomes
#14
Raghav Sundar, Aditi Qamra, Angie Lay Keng Tan, Shenli Zhang, Cedric Chuan Young Ng, Bin Tean Teh, Jeeyun Lee, Kyoung-Mee Kim, Patrick Tan
BACKGROUND: Epstein-Barr virus-associated gastric cancer (EBVaGC) has traditionally been associated with high expression of PD-L1 and immune infiltration. Correlations between PD-L1 and other immune-related gene (IRG) expressions in EBVaGC have not been previously described. METHODS: We performed NanoString® transcriptomic profiling and PD-L1 immunohistochemistry (IHC) (using the FDA approved Dako PD-L1 IHC 22C3) on EBVaGC samples from gastric cancer patients undergoing primary tumor resections at Samsung Medical Centre, South Korea...
June 18, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29915951/prediction-of-survival-with-multi-scale-radiomic-analysis-in-glioblastoma-patients
#15
Ahmad Chaddad, Siham Sabri, Tamim Niazi, Bassam Abdulkarim
We propose a multiscale texture features based on Laplacian-of Gaussian (LoG) filter to predict progression free (PFS) and overall survival (OS) in patients newly diagnosed with glioblastoma (GBM). Experiments use the extracted features derived from 40 patients of GBM with T1-weighted imaging (T1-WI) and Fluid-attenuated inversion recovery (FLAIR) images that were segmented manually into areas of active tumor, necrosis, and edema. Multiscale texture features were extracted locally from each of these areas of interest using a LoG filter and the relation between features to OS and PFS was investigated using univariate (i...
June 19, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29915948/thyroid-hormone-receptor-beta-1-expression-in-early-breast-cancer-a-validation-study
#16
K J Jerzak, J G Cockburn, S K Dhesy-Thind, G R Pond, K I Pritchard, S Nofech-Mozes, P Sun, S A Narod, A Bane
PURPOSE: Preliminary data suggest that high expression of the TRβ1 tumor suppressor is associated with longer survival among women with early breast cancer. We undertook this study to validate these findings. METHODS: In this prospective cohort study, we analyzed the prognostic significance of TRβ1 protein expression in the breast tumors of 796 women who had undergone breast surgery in the Henrietta Banting Breast Cancer database. All women were recruited after undergoing primary surgical therapy at Women's College Hospital (Toronto, ON, Canada) between January 1987 and December 2000...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915946/impact-of-change-in-body-mass-index-during-neoadjuvant-chemotherapy-and-survival-among-breast-cancer-subtypes
#17
Takahiro Kogawa, Takeo Fujii, Tamer M Fouad, Diane D Liu, Kenichi Harano, Hiroko Masuda, Toshiaki Iwase, Chad Barnett, Young Sam Park, Bora Lim, Debu Tripathy, Jennifer K Litton, Naoto T Ueno
PURPOSE: We hypothesized that an increase in BMI category during neoadjuvant chemotherapy (NAC) would be associated with pathological complete response (pCR) rate and worse survival outcomes in primary breast cancer patients. METHODS: We reviewed the records of 4029 patients with stage I-III breast cancer who had undergone NAC and definitive surgery at our institution between May 1, 1990 and April 30, 2013. BMI values at baseline and after NAC were recorded, and the corresponding BMI category was assessed with the WHO classification...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915904/the-influence-of-tumour-site-on-prognosis-in-metastatic-colorectal-carcinomas-with-primary-tumour-resection
#18
Susanne Merkel, Vera S Schellerer, Axel Wein, Sabine Semrau, Carol Geppert, Jonas Göhl, Werner Hohenberger, Klaus Weber, Robert Grützmann
PURPOSE: The aim of our study was to compare the characteristics and prognosis between right- and left-sided metastatic colorectal carcinomas. METHODS: Data from 937 patients with stage IV colorectal carcinomas (synchronous distant metastasis) who had a resection of the primary tumour between 1985 and 2014 were analysed. Carcinomas in the caecum to transverse colon were defined as right-sided (n = 250; 26.7%). They were compared to tumours located from the splenic flexure to the rectum categorised as left-sided (n = 687; 73...
June 18, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29915882/androgen-receptor-and-ki67-expression-and-survival-outcomes-in-non-small-cell-lung-cancer
#19
Laurel Grant, Shantanu Banerji, Leigh Murphy, David E Dawe, Craig Harlos, Yvonne Myal, Zoann Nugent, Anne Blanchard, Carla R Penner, Gefei Qing, Marshall W Pitz
Lung cancer is the most common cause of cancer-related deaths worldwide with non-small cell lung cancer (NSCLC) making up most of these cases. Males have poorer overall survival compared to women following a lung cancer diagnosis. Many studies have focused on the effects of estrogen to explain higher survival rates among women, but few have looked at the effects of androgens. We describe the expression of the androgen receptor (AR) and Ki67 in lung cancer specimens in the Manitoba Tumor Bank (MTB) and correlate these factors with patient outcome...
June 18, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29915641/effects-of-educational-messaging-on-urgent-and-emergent-care-seeking-behaviors-among-publicly-insured-populations
#20
Jesse Cambon, Tristan Cordier, Elizabeth L Munnich, Andrew Renda, Bobby Kapur, Shkelzen Hoxhaj, Meredith Williams
Background: The impact of messaging campaigns on influencing urgent care- and emergent care-seeking behaviors, including the use of in-network providers, is not well-understood. Although out-of-network healthcare utilization can have negative financial consequences for patients in narrow network Affordable Care Act plans, individuals with time-sensitive medical conditions, and especially patients visiting the emergency department, may not think about out-of-network issues. Inappropriate or avoidable emergency department visits can also create unnecessary costs for patients...
April 2018: American Health & Drug Benefits
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