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Perrine Truong, Gregoire P Millet, Boris Gojanovic
This study aimed to investigate the differences in maximal oxygen uptake (V̇O2max ) and submaximal thresholds between a standard graded exercise test (GXT) and a perceptually regulated graded exercise test (PRGXT) in trained runners. Eleven well-trained middle- to long-distance runners performed both tests in a randomized order. PRGXT used incremental "clamps" of rating of perceived exertion (RPE) over 10×1-min stages on an automated treadmill equipped with a sonar sensor allowing them to change their running speed instantly and in a natural way...
February 23, 2018: International Journal of Sports Medicine
Sandro Pasquali, Chiara Colombo, Sara Pizzamiglio, Paolo Verderio, Dario Callegaro, Silvia Stacchiotti, Javier Martin Broto, Antonio Lopez-Pousa, Stefano Ferrari, Andres Poveda, Antonino De Paoli, Vittorio Quagliuolo, Josefina Cruz Jurado, Alessandro Comandone, Giovanni Grignani, Rita De Sanctis, Elena Palassini, Antonio Llomboart-Bosch, Angelo Paolo Dei Tos, Paolo G Casali, Piero Picci, Alessandro Gronchi
BACKGROUND: Patients with extremity and trunk wall soft tissue sarcoma (STS) with high malignancy grade and size >5 cm are at high-risk of death. This risk varies depending also on other patient and tumour features, including histologic subtype. This study investigated whether a prognostic nomogram can improve risk assessment of these patients. METHODS: Data from high-risk STS patients enrolled in a randomised controlled trial investigating different perioperative chemotherapy regimens were analysed...
February 20, 2018: European Journal of Cancer
Emanuel Citgez, Maaike Zuur-Telgen, Job van der Palen, Paul van der Valk, Daiana Stolz, Marjolein Brusse-Keizer
BACKGROUND: Elevated levels of Midrange-proadrenomedullin (MR-proADM) is associated with worse outcome in different diseases among which COPD. The association of stable state MR-proADM with severe exacerbations of COPD requiring hospitalisation (severe AECOPD), or with community acquired pneumonia (CAP) in COPD patients has not been studied yet. AIMS AND OBJECTIVES: The aim of this study was to evaluate the association of stable state MR-proADM with severe AECOPD and CAP in COPD patients...
February 20, 2018: Chest
I P Munugoda, K Wills, F Cicuttini, S E Graves, M Lorimer, G Jones, M L Callisaya, D Aitken
OBJECTIVE: To examine the association between ambulatory activity (AA), body composition measures and hip or knee joint replacement (JR) due to osteoarthritis. DESIGN: At baseline, 1082 community-dwelling older-adults aged 50 - 80 years were studied. AA was measured objectively using pedometer and body composition by dual-energy x-ray absorptiometry. The incidence of primary (first-time) JR was determined by data linkage to the Australian Orthopaedic Association National Joint Replacement Registry...
February 20, 2018: Osteoarthritis and Cartilage
Jeppe V Rasmussen, Randi Hole, Trygve Metlie, Stig Brorson, Ville Äärimaa, Yilmaz Demir, Björn Salomonsson, Steen L Jensen
OBJECTIVE: To report the10-year survival rates of different shoulder arthroplasty types used for glenohumeral osteoarthritis. DESIGN: Data from 2004-2013 was prospectively collected by the national shoulder arthroplasty registers in Denmark, Norway and Sweden and merged into a harmonized dataset under the umbrella of the Nordic Arthroplasty Register Association. The common dataset included data that all three registers could deliver and where consensus regarding definitions could be made...
February 20, 2018: Osteoarthritis and Cartilage
Tsuyoshi Hamada, Natalia Khalaf, Chen Yuan, Vicente Morales-Oyarvide, Ana Babic, Jonathan A Nowak, Zhi Rong Qian, Kimmie Ng, Douglas A Rubinson, Peter Kraft, Edward L Giovannucci, Meir J Stampfer, Charles S Fuchs, Shuji Ogino, Brian M Wolpin
BACKGROUND & AIMS: Statin medications, most commonly prescribed to reduce lipid levels and prevent cardiovascular disease, may be associated with longer survival times of patients with cancer. However, the association of statins with outcomes of patients with pancreatic adenocarcinoma is not clear. METHODS: We analyzed the association of statin use before a diagnosis of pancreatic cancer with survival times of 648 participants in the Nurses' Health Study and Health Professionals Follow-up Study who were diagnosed with pancreatic adenocarcinoma from 2000 through 2013...
February 20, 2018: Clinical Gastroenterology and Hepatology
Arghajit Pyne, Sangita Kundu, Pavel Banerjee, Nilmoni Sarkar
In this article, we have unveiled the aggregation behavior of a potent chemotherapeutic drug, doxorubicin hydrochloride (Dox) in a well known imidazolium based surface active ionic liquid (SAIL), 1-octyl-3-methylimidazolium chloride (C8mimCl). The aggregates formed by Dox in C8mimCl have been characterized using dynamic light scattering (DLS), fluorescence lifetime imaging microscopy (FLIM), high resolution transmission electron microscopy (HR-TEM), analytical transmission electron microscopy (analytical TEM), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and fourier-transform infrared spectroscopy (FTIR) measurements...
February 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Danila Coradini, Annalisa Orenti, Elisabetta Venturelli, Adalberto Cavalleri, Elia Biganzoli, Saro Oriana
Objective: To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI). Methods: We investigated 120 women with primary breast cancer and median follow-up of 138 months. Serum levels of TS and SHBG and patient's BMI were evaluated before surgery...
February 21, 2018: Japanese Journal of Clinical Oncology
Dietmar Enko, Andreas Meinitzer, Hubert Scharnagl, Tatjana Stojakovic, Marcus E Kleber, Graciela E Delgado, Sieglinde Zelzer, Christiane Drechsler, Bernhard K Krämer, Christoph Wanner, Winfried März, Rainer P Woitas
Background: Beta-trace protein (BTP) is a low-molecular-weight glycoprotein, which may serve as an endogenous biomarker of kidney function and cardiovascular risk. Methods: We examined cardiovascular and all-cause mortality according to BTP concentrations in 2962 individuals referred for coronary angiography from the Ludwigshafen Risk and Cardiovascular Health study and in 907 patients with Type 2 diabetes mellitus undergoing haemodialysis from the German Diabetes and Dialysis (4D) study...
February 20, 2018: Nephrology, Dialysis, Transplantation
Ben Kang, So Yoon Choi, Young Ok Choi, Min-Ji Kim, Kyunga Kim, Ji-Hyuk Lee, Yon Ho Choe
Background and aims: We aimed to investigate the outcome in paediatric-onset Crohn's disease patients who had discontinued infliximab after maintaining clinical remission with combined immunosuppression, and to determine factors associated with clinical relapse. Methods: We conducted a retrospective observational study of 63 paediatric-onset Crohn's disease patients who had stopped scheduled infliximab during sustained corticosteroid-free clinical remission for at least 1 year with infliximab and azathioprine, and were followed up for at least 1 year thereafter...
February 21, 2018: Journal of Crohn's & Colitis
Emmanouil Kalampokas, Judith Wilson, Mahalakshmi Gurumurthy, Margaret E Cruickshank
OBJECTIVE: In United Kingdom., test of cure after treatment of any grade of cervical intraepithelial neoplasia (CIN) incorporates high-risk human papillomavirus (Hr-HPV) test and cytology at 6-month follow-up. The aims of the study were to determine the rate of recurrent CIN in women who are Hr-HPV positive and cytology negative and to explore possible associated risk factors. METHODS: A retrospective observational cohort study was performed in women treated for any grade CIN between 2010 and 2015 from a regional population, who were Hr-HPV positive and cytology negative at first follow-up...
February 23, 2018: Journal of Lower Genital Tract Disease
Urtats Etxegarai, Ainhoa Insunza, Jon Larruskain, Jordan Santos-Concejero, Susana M Gil, Eva Portillo, Jon Irazusta
We investigated whether heart rate (HR)-derived parameters are accurate performance predictors in endurance recreational runners. One hundred thirty recreational athletes completed an incremental running test (4´running + 1´rest). After each stage, we recorded HR, % of maximum HR (%HRmax), and blood lactate. We also assessed HR after each recovery period, and calculated lactate and HR recovery thresholds and HR deflection point. We tested these parameters for associations with running performance, as measured by peak treadmill speed (PTS) and personal best International Association of Athletics Federations (IAAF) score...
February 23, 2018: Journal of Sports Sciences
Débora Wanderley, Andrea Lemos, Eduarda Moretti, Manuella Moraes Monteiro Barbosa Barros, Marcelo Moraes Valença, Daniella Araújo de Oliveira
The objective of this study was to evaluate the efficacy of proprioceptive neuromuscular facilitation (PNF) on range of motion (ROM) gain in young healthy adults. We performed a systematic review of randomized controlled trials and quasi-randomized trials, including young healthy adults. The interventions were: PNF compared with different PNF techniques, control, other muscle stretching exercises and musculoskeletal manipulations. The outcome measures were: articular ROM and adverse effects. The final number of included studies was 46, involving 1,864 adults...
February 23, 2018: Physiotherapy Theory and Practice
Kieran J Rothnie, Hana Müllerová, Liam Smeeth, Jennifer K Quint
Rationale Acute exacerbations (AECOPD) are important adverse events in the natural history of COPD. Objectives To investigate the natural history of AECOPD over 10-years of follow-up. Methods and Results We identified 99,574 patients with COPD 01/Jan/04-31/March/15 from the UK Clinical Practice Research Datalink. We defined moderate AECOPD as those managed outside hospital and severe as those requiring hospitalisation. During the baseline period (first year of follow-up), patients were grouped according to the number and severity of AECOPD and then followed for a maximum of 10 years (mean 4...
February 23, 2018: American Journal of Respiratory and Critical Care Medicine
Luca Ferrero, Grisa Mocnik, Sergio Cogliati, Asta Gregoric, Roberto Colombo, Ezio Bolzacchini
Light Absorbing Aerosols (LAA) absorb sunlight and heat the atmosphere. This work presents a novel methodology to experimentally quantify the heating rate (HR) induced by LAA into an atmospheric layer. Multi-wavelength aerosol absorption measurements were coupled with spectral measurements of the direct, diffuse and surface reflected radiation to obtain highly-time resolved measurements of HR apportioned in the context of LAA species (Black Carbon, BC; Brown Carbon, BrC; dust), sources (fossil fuel, FF; and biomass burning, BB), and as a function of cloudiness...
February 23, 2018: Environmental Science & Technology
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
Katie S Murray, Emily A Vertosick, Massimiliano Spaliviero, Joseph W Mashni, Daniel D Sjoberg, Kaled M Alektiar, Harry W Herr, Paul Russo, Jonathan A Coleman
BACKGROUND AND OBJECTIVES: We evaluated the effect of re-resection with wide margins (undertaken because initial resection performed elsewhere was incomplete) on survival in patients with spermatic cord sarcoma (SCS). METHODS: After excluding those with metastatic disease and those not undergoing surgical intervention, the records of 72 consecutive patients treated for SCS between 1981 and 2011 at Memorial Sloan Kettering Cancer Center were reviewed. Recurrence-free survival (RFS) and cancer-specific survival were calculated using the Kaplan-Meier method for comparing between the 48 patients who underwent wide re-resection (WRR) within 5 months of diagnosis and the 24 who did not...
February 23, 2018: Journal of Surgical Oncology
Kazunari Sasaki, Junichi Shindoh, Yujiro Nishioka, Toshitaka Sugawara, Georgios A Margonis, Nikolaos Andreatos, Timothy M Pawlik, Masaji Hashimoto
BACKGROUND: Preoperative hepatitis C virus (HCV) viral load is known to predict long-term outcomes after hepatectomy for HCV-related hepatocellular carcinoma (HCC). This study sought to examine the hypothesis that postoperative and preoperative HCV viral-load have similar prognostic implications, as well as determine a target viral-load that will improve long-term postoperative outcomes. METHOD: One hundred and eighty-one patients who underwent curative hepatectomy for HCV-related HCC were divided into five groups according to time-weighted average viral load...
February 23, 2018: Journal of Surgical Oncology
Mohamed Farag, Wael M Abdel-Mageed, Omer Basudan, Ali El-Gamal
Salvadora persica L. is a popular chewing stick commonly known as "miswak". During our ongoing research activities on the chemical constituents of Salvadora persica roots, which is a new sulphur-containing imidazoline alkaloid 1,3-Dibenzyl-4-(1,2,3,4-tetrahydroxy-butyl)-1,3-dihydro-imidazole-2-thione, persicaline, ( 1 ) along with five known compounds ( 2 - 6 ) are identified. Compounds ( 2 , 3 ) were reported for the first time from the family Salvadoraeceae . The structure of the new compound was established by extensive spectroscopic data and HR-MS...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mahesh Raj Nepal, Youra Kang, Mi Jeong Kang, Doo Hyun Nam, Tae Cheon Jeong
Although the Organization for Economic Cooperation and Development (OECD) has adopted several in vitro methods with reasonable predictive capacity, alternative methods for identifying skin sensitizers and non-sensitizers with reliability and simplicity are still required for more efficient and economic prediction. The present study was to design an in vitro system with the use of a β-galactosidase-expressing E. coli culture for simpler but sufficiently accurate classification of skin sensitizers and non-sensitizers...
February 23, 2018: Journal of Toxicology and Environmental Health. Part A
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