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Frédéric Fiteni, Sophie Paget-Bailly, Mathieu Messager, Thierry N'Guyen, Zaher Lakkis, Pierre Mathieu, Najib Lamfichekh, Alain Picard, Bilell Benzidane, Denis Cléau, Franck Bonnetain, Christophe Borg, Christophe Mariette, Stefano Kim
Docetaxel, cisplatin, and 5-fluorouracil (DCF) significantly improved overall survival in metastatic gastroesophageal adenocarcinoma (GEA). The aim of this study was to assess efficacy of DCF regimen as perioperative chemotherapy compared with surgery alone in patients with resectable GEA. We identified 789 patients who underwent surgery alone and 62 patients who received at least one cycle of DCF regimen consisting of docetaxel (75 mg/m(2) on day 1), cisplatin (75 mg/m(2) on day 1), and 5-fluorouracil (750 mg/m(2) /day on continuous perfusion on days 1 to 5), every 3 weeks...
October 11, 2016: Cancer Medicine
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
Georgios C Sotiropoulos, Nikolaos Machairas, Paraskevas Stamopoulos, Ioannis D Kostakis, Dimitrios Dimitroulis, Dimitrios Mantas, Gregory Kouraklis
BACKGROUND: Liver resection represents the treatment of choice for a small proportion of patients with hepatocellular carcinoma (HCC), amenable to surgery. The remarkable evolution in surgical techniques during the last decades introduced laparoscopic hepatectomy in the operative management of HCC, even in the presence of liver cirrhosis. No comparative study on laparoscopic or open liver resection for HCC has been conducted in Greece yet. METHODS: Patients undergoing liver resection for HCC by one senior hepatobiliary surgeon in our Institution during the period 11/2011-02/2016 were prospectively sampled and retrospectively analyzed for the purposes of this study...
October 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Vidyadhar V Upasani, Oliver Birke, Kevin E Klingele, Michael B Millis
BACKGROUND: The modified Dunn procedure facilitates femoral capital realignment for slipped capital femoral epiphysis (SCFE) through a surgical hip dislocation approach. Iatrogenic postoperative hip instability after this procedure has not been studied previously; however, we were concerned when we observed several instances of this serious complication, and we wished to study it further. QUESTIONS/PURPOSES: The purpose of this study was to evaluate the frequency, timing, and clinical presentation (including complications) associated with iatrogenic instability after the modified Dunn procedure for SCFE...
September 20, 2016: Clinical Orthopaedics and related Research
Julie Navez, Christophe Remue, Daniel Leonard, Radu Bachmann, Alex Kartheuser, Catherine Hubert, Laurent Coubeau, Mina Komuta, Marc Van den Eynde, Francis Zech, Nicolas Jabbour
BACKGROUND: Chemotherapeutic advances have enabled successful cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) expansion in treating metastatic colorectal cancer. OBJECTIVES: The aims of this study were to evaluate the safety of combining liver surgery (LS) with HIPEC and CRS (which remains controversial) and its impact on overall survival (OS) rates. METHODS: From 2007 to 2015, a total of 77 patients underwent CRS/HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer...
September 19, 2016: Annals of Surgical Oncology
A Doussot, C Lim, C Gómez Gavara, D Fuks, O Farges, J M Regimbeau, D Azoulay
BACKGROUND: The impact of morbidity on long-term outcomes following liver resection for intrahepatic cholangiocarcinoma is currently unclear. METHODS: This was a retrospective analysis of all consecutive patients who underwent liver resection for intrahepatic cholangiocarcinoma with curative intent in 24 university hospitals between 1989 and 2009. Severe morbidity was defined as any complication of Dindo-Clavien grade III or IV. Patients with severe morbidity were compared with those without in terms of demographics, pathology, management, morbidity, overall survival, disease-free survival and time to recurrence...
September 15, 2016: British Journal of Surgery
Riccardo Memeo, Vito de Blasi, René Adam, Diane Goéré, Daniel Azoulay, Ahmet Ayav, Emilie Gregoire, Reza Kianmanesh, Francis Navarro, Antonio Sa Cunha, Patrick Pessaux
OBJECTIVE: The aim of this study is to evaluate whether a parenchymal-sparing strategy provides similar results in terms of morbidity, mortality, and oncological outcome of non-PSH hepatectomies in a propensity score matched population (PSMP) in case of multiple (>3) bilobar colorectal liver metastases (CLM). BACKGROUND: The surgical treatment of bilobar liver metastasis is challenging due to the necessity to achieve complete resection margins and a sufficient future remnant liver...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Caitlin W Hicks, Katherine E Poruk, Pablo A Baltodano, Kevin C Soares, Said C Azoury, Carisa M Cooney, Peter Cornell, Frederic E Eckhauser
BACKGROUND: Sandwich ventral hernia repair (SVHR) may reduce ventral hernia recurrence rates, although with an increased risk of surgical site occurrences (SSOs) and surgical site infections (SSIs). Previously, we found that a modified negative pressure wound therapy (hybrid vacuum-assisted closure [HVAC]) system reduced SSOs and SSIs after ventral hernia repair. We aimed to describe our outcomes after SVHR paired with HVAC closure. METHODS: We conducted a 4-y retrospective review of all complex SVHRs (biologic mesh underlay and synthetic mesh overlay) with HVAC closure performed at our institution by a single surgeon...
August 2016: Journal of Surgical Research
M Knaak, N Goldaracena, A Doyle, M S Cattral, P D Greig, L Lilly, I D McGilvray, G A Levy, A Ghanekar, E L Renner, D R Grant, M Selzner, N Selzner
The increased prevalence of obesity worldwide threatens the pool of living liver donors. While the negative effects of graft steatosis on liver donation and transplantation is well known, the impact of obesity in the absence of hepatic steatosis on outcome of living donor liver transplantation (LDLT) is unknown. Therefore, we compared the outcome of LDLT using donors with a BMI<30kg/m(2) vs donors with a BMI ≥30kg/m(2) . Between April 2000-May 2014, 105 patients received a right lobe liver graft from donors with BMI ≥30kg/m(2) , while 364 recipients were transplanted with grafts from donors with BMI<30kg/m(2) ...
August 22, 2016: American Journal of Transplantation
T Grochowiecki, K Madej, Z Gałązka, T Jakimowicz, M Jędrasik, P Świercz, K Łukawski, L Pączek, M Durlik, S Nazarewski, J Szmidt
OBJECTIVE: Simultaneous pancreas and kidney transplantation (spktx) is the multiorgan transplantation. Thus various complications originated from transplanted organs and the complications that are not directly related to pancreatic or renal grafts could be developed at the same recipient. AIM: The aim of this study is to explore whether there is a correlation between the severity of complications originated from transplanted pancreas, transplanted kidney and general surgical complication developed at the same spktx recipient...
June 2016: Transplantation Proceedings
Paulo Herman, Felipe de Lucena Moreira Lopes, Jaime Arthur Pirola Kruger, Gilton Marques Fonseca, Vagner Birk Jeismann, Fabricio Ferreira Coelho
BACKGROUND: - Liver resection for hepatocellular carcinoma is a potentially curative therapeutic procedure that can be performed readily after its indication, without the need of a long waiting time and lower costs when compared to liver transplantation, being a good alternative in patients with preserved/good liver function. OBJECTIVE: - Evaluate long-term results of liver resection from a high volume single center for selected patients with hepatocellular carcinoma in a context of a long waiting list for liver transplant...
July 2016: Arquivos de Gastroenterologia
Markus Selzner, Nicolas Goldaracena, Juan Echeverri, Johan M Kaths, Ivan Linares, Nazia Selzner, Cyril Serrick, Max Marquez, Gonzalo Sapisochin, Eberhard L Renner, Mamatha Bhat, Ian D McGilvray, Leslie Lilly, Paul D Greig, Cynthia Tsien, Mark S Cattral, Anand Ghanekar, David R Grant
: The European trial investigating normothermic ex vivo liver perfusion (NEVLP) as a preservation technique for liver transplantation (LT) uses Gelofusine(TM) , a non-FDA approved bovine derived gelatin-based perfusion solution. We report a safety and feasibility clinical NEVLP trial with human albumin based Steen solution. METHODS: Transplant outcomes of 10 human liver grafts that were perfused on the Metra(TM) device at 37°C with Steen solution, plus 3 units of erythrocytes were compared to a matched historical control group of 30 grafts using cold storage (CS) as the preservation technique...
June 24, 2016: Liver Transplantation
Leila Meghelli, Fabrice Narducci, Christophe Mariette, Guillaume Piessen, Marie Vanseymortier, Eric Leblanc, Pierre Collinet, Alain Duhamel, Nicolas Penel
BACKGROUND: Few reports describe how adverse events (AEs) are reported in cancer surgery trials. MATERIALS AND METHODS: We systematically reviewed 179 consecutive study reports issued between January 1, 1990 and November 15, 2014, which investigated surgery in oesophago-gastric (OG) or gynecologic (GY) cancer patients. Based on the reviewed reports, we assessed how AEs were reported according to CONSORT statement. RESULTS: Morbidity assessment was the primary objective of 56 studies (31...
August 2016: Critical Reviews in Oncology/hematology
Keitaro Sofue, Yoshito Takeuchi, Masakatsu Tsurusaki, Kentaro Shibamoto, Noriaki Sakamoto, Kazuhiro Kitajima, Miyuki Sone, Kazuro Sugimura, Yasuaki Arai
BACKGROUND: Nutritional management is important throughout the treatment period for esophageal cancer patients. This study aimed to evaluate the feasibility of percutaneous radiologic gastrostomy (PRG) and to investigate whether PRG can be applied for patients with advanced esophageal cancer. METHODS: In this study, 89 patients (74 men and 15 women) with advanced esophageal cancer underwent PRG using computed tomography and fluoroscopic guidance. These patients were unsuitable candidates for endoscopic intervention because of esophageal stricture...
October 2016: Annals of Surgical Oncology
Ido Nachmany, Niv Pencovich, Amir Ben-Yehuda, Guy Lahat, Richard Nakache, Yaacov Goykhman, Nir Lubezky, Joseph M Klausner
BACKGROUND: Although laparoscopic distal pancreatectomy (LDP) is gradually recognized as a safe and effective alternative to open distal pancreatectomy (ODP), it is not yet widely accepted. OBJECTIVE: We describe our experience, with emphasis on the learning curve of LDP. METHODS: Patients who underwent distal pancreatectomy (DP) between January 2011 and August 2014 were included. Operative and postoperative parameters, as well as pathology reports were evaluated...
June 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hugo Teixeira Farinha, Emmanuel Melloul, Dieter Hahnloser, Nicolas Demartines, Martin Hübner
BACKGROUND: Primary anastomosis is considered the standard strategy after right emergency colectomy. The present study aimed to evaluate alternative treatment strategies when primary anastomosis is not possible to prevent definitive ostomy. METHODS: This retrospective study included all consecutive patients who underwent right emergency colectomy between July 2006 and June 2013. Demographics, surgical data, and postoperative outcomes were entered in an anonymized database...
2016: World Journal of Emergency Surgery: WJES
Jiansong Ji, Jun Gao, Lizhen Zhao, Jianfei Tu, Jingjing Song, Wenbing Sun
The aim of the study was to evaluate the feasibility, safety, and efficacy of computed tomography (CT)-guided radiofrequency (RF) ablation combined with transcatheter arterial embolization (TAE) to treat large (≥10 cm) hepatic hemangiomas. We retrospectively reviewed our sequential experience with 15 large hepatic hemangiomas in 15 patients. The mean diameter of the 15 hemangiomas was 13.0 ± 2.2 cm (10.0-16.0 cm). RF ablation combined with TAE treatment was performed successfully in all patients...
April 2016: Medicine (Baltimore)
Takeo Nomi, David Fuks, Christophe Louvet, Yoshiyuki Nakajima, Brice Gayet
BACKGROUND: Despite the expansion of laparoscopic approach in the treatment of liver tumors, limited data have been reported regarding large colorectal liver metastases (CRLMs). This study aimed at assessing the short- and long-term outcomes after laparoscopic liver resection (LLR) for large (≥5 cm) CRLMs. METHODS: This was a case-matched study (1:2) comparing patients with large (group L; ≥5 cm) and small (group S; <5 cm) CRLMs using demographic, tumor, and surgical characteristics as matching variables...
July 2016: World Journal of Surgery
C Codony, S López-Ben, M Albiol, L Falgueras, E Castro, A Codina-Barreras, M Casellas, J Gil, A Codina-Cazador, J Figueras
OBJECTIVE: Analyze the characteristics, surgical technique, morbidity and survival of patients treated with extreme liver surgery. MATERIALS AND METHODS: We present a series of consecutive patients with malignant liver tumors in hepatocaval confluence treated in a single center with extreme liver surgery (April 2008-March 2015). Data were collected prospectively and analyzed with SPSS 21.0. RESULTS: 12 patients were included. 50 % were male and 50 % were female with a mean age of 59 ± 10 years old...
March 10, 2016: Clinical & Translational Oncology
Jun Gao, Jian-Song Ji, Xue-Mei Ding, Shan Ke, Zong-Hai Xin, Chun-Min Ning, Shi-Gang Guo, Xiao-Long Li, Yong-Hong Dong, Wen-Bing Sun
OBJECTIVES: The aim of this study was to evaluate the technical and clinical outcomes of using laparoscopic radiofrequency (RF) ablation for treating large subcapsular hepatic hemangiomas. METHODS: We retrospectively reviewed our sequential experience of treating 124 large subcapsular hepatic hemangiomas in 121 patients with laparoscopic RF ablation. RESULTS: The mean diameter of the 124 hemangiomas was 9.1 ± 3.2 cm (5.0-16.0 cm). RF ablation was performed successfully in all patients...
2016: PloS One
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