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https://www.readbyqxmd.com/read/29208398/future-cancer-research-priorities-in-the-usa-a-lancet-oncology-commission
#1
REVIEW
Elizabeth M Jaffee, Chi Van Dang, David B Agus, Brian M Alexander, Kenneth C Anderson, Alan Ashworth, Anna D Barker, Roshan Bastani, Sangeeta Bhatia, Jeffrey A Bluestone, Otis Brawley, Atul J Butte, Daniel G Coit, Nancy E Davidson, Mark Davis, Ronald A DePinho, Robert B Diasio, Giulio Draetta, A Lindsay Frazier, Andrew Futreal, Sam S Gambhir, Patricia A Ganz, Levi Garraway, Stanton Gerson, Sumit Gupta, James Heath, Ruth I Hoffman, Cliff Hudis, Chanita Hughes-Halbert, Ramy Ibrahim, Hossein Jadvar, Brian Kavanagh, Rick Kittles, Quynh-Thu Le, Scott M Lippman, David Mankoff, Elaine R Mardis, Deborah K Mayer, Kelly McMasters, Neal J Meropol, Beverly Mitchell, Peter Naredi, Dean Ornish, Timothy M Pawlik, Jeffrey Peppercorn, Martin G Pomper, Derek Raghavan, Christine Ritchie, Sally W Schwarz, Richard Sullivan, Richard Wahl, Jedd D Wolchok, Sandra L Wong, Alfred Yung
We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment...
November 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29206742/the-authors-reply
#2
Joshua J Blinder, Michael S D Agus, Michael A Ferguson
No abstract text is available yet for this article.
December 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29203378/occurrence-of-acanthamoeba-genotypes-in-central-west-malaysian-environments
#3
Mohamad Hafiz Abdul Basher, Init Ithoi, Rohela Mahmud, Awatif Mohamed Abdulsalam, Agus Iwan Foead, Salwa Dawaki, Wahib Mohammed Mohsen Atroosh, Veeranoot Nissapatorn, Wan Omar Abdullah
Acanthamoeba species are ubiquitous free-living protozoa that can be found worldwide. Occasionally, it can become parasitic and the causative agent of acanthamoebic keratitis (AK) and Granulomatous Amoebic Encephalitis (GAE) in man. A total of 160 environmental samples and 225 naturally-infected animal corneal swabs were collected for Acanthamoeba cultivation. Acanthamoeba was found to be high in samples collected from environments (85%, 136/160) compared to infected animal corneas (24.89%, 56/225) by microscopic examination...
December 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29179744/levels-trends-and-correlates-of-unmet-need-for-family-planning-among-postpartum-women-in-indonesia-2007-2015
#4
Siswanto Agus Wilopo, Althaf Setyawan, Anggriyani Wahyu Pinandari, Titut Prihyugiarto, Flourisa Juliaan, Robert J Magnani
BACKGROUND: Although Indonesia has relatively high contraceptive prevalence, postpartum family planning (PP-FP) has not been a particular point of emphasis. This article reports the results of analyses undertaken in order to (1) better understand levels and trends in unmet need for family planning among postpartum women, (2) assess the extent to which unmet need is concentrated among particular population sub-groups, and (3) assess the policy priority that PP-FP should have in relation to other interventions...
November 28, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29172288/prevalence-of-abnormal-pap-smears-a-descriptive-study-from-a-cancer-center-in-a-low-prevalence-community
#5
Bayan Maraqa, Isam Lataifeh, Lian Otay, Osama Badran, Yasar Qutaiba Nouri, Ibtihal Issam, Maysa Al Hussaini
Background and aims: Cervical cancer is the fourth most common cancer in women worldwide and the 13th in Jordan. The cervical smear (Pap smear) is a simple approach to detect pre-cancerous cervical lesions. The aim of this study was to evaluate the prevalence of abnormal cervical smears in women seen at the Early Detection/Community Outreach clinic of King Hussein Cancer Center (KHCC). Materials and Methods: In this retrospective study, reports of routine cervical Pap smears performed in the pathology department at KHCC from January 2007 to December 2016, were reviewed...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29099002/adenocarcinoma-of-the-lung-with-positive-epidermal-growth-factor-receptor-mutation-in-pregnancy
#6
Gina Amanda, Agus Dwi Susanto, Dicky Soehardiman, Dianiati Kusumo Sutoyo, Yuyun Lisnawati, Boy Busmar, Andika Chandra Putra, Erlang Samoedro, Elisna Syahruddin
Lung cancer during pregnancy is a rare condition. We report a case of 28-year-old nonsmoker female, who was admitted to our hospital with massive left pleural effusion in the 21st week of gestation. Chest radiograph showed total left hemithorax opacity with contralateral mediastinal deviation. Pleural biopsy and cytological examination of pleural fluid revealed adenocarcinoma invasion with positive epidermal growth factor receptor mutation status. Cesarean section was performed at 32 weeks of pregnancy, and targeted therapy was given to this patient after delivery...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29093235/pollen-serum-specific-ige-sensitization-in-respiratory-allergic-patients-in-jakarta-indonesia
#7
Iris Rengganis, Agus Joko Susanto
BACKGROUND: pollens from trees or grasses in Indonesia have a perennial distribution due to the tropical climate. However, pollen allergy has not been well studied. This study aimed to evaluate the profile of pollen IgE sensitization in respiratory allergic patients in Jakarta. METHODS: this was a cross-sectional study in patients with a history of respiratory allergy in Jakarta, Indonesia between September and December 2016. Adult asthmatic patients aged 19-60 years were invited to undergo serum specific IgE testing at the Allergy and Immunology Clinic, Cipto Mangunkusumo Hospital, Jakarta...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29092589/auditory-memory-for-random-time-patterns
#8
HiJee Kang, Trevor R Agus, Daniel Pressnitzer
The acquisition of auditory memory for temporal patterns was investigated. The temporal patterns were random sequences of irregularly spaced clicks. Participants performed a task previously used to study auditory memory for noise [Agus, Thorpe, and Pressnitzer (2010). Neuron 66, 610-618]. The memory for temporal patterns displayed strong similarities with the memory for noise: temporal patterns were learnt rapidly, in an unsupervised manner, and could be distinguished from statistically matched patterns after learning...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29051633/rapid-test-for-the-determination-of-total-phenolic-content-in-brewed-filtered-coffee-using-colorimetric-paper
#9
Mochammad Amrun Hidayat, Nindya Puspitaningtyas, Agus Abdul Gani, Bambang Kuswandi
This work was aimed to develop a chemical sensor for the determination of total polyphenol content (TPC) of coffee samples. The polyphenol sensor was based on co-immobilization of NaIO4 and MBTH in paper as a test strip. The sensor showed sensitive response to chlorogenic acid by forming pink color adduct which can be scanned and quantified by Imagej program. The sensor had response time of 14 min and a linear range between 0.07 and 0.71 mM of chlorogenic acid with a detection limit at 0.002 mM toward chlorogenic acid...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29016331/determining-the-cause-of-death-mortality-surveillance-using-verbal-autopsy-in-indonesia
#10
Abdul Wahab, Ifta Choiriyyah, Siswanto Agus Wilopo
In the absence of a vital registration and health information systems, Indonesia does not have complete, accurate, and continuous data to summarize the mortality statistics of the population, nor determine the exact cause of death. Verbal autopsies performed in a community-based mortality surveillance have been used to provide information on the cause of deaths in such context. However, physician review of verbal autopsy can be expensive, time-consuming, and give inconsistent results, raising concern about its reliability...
October 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28979565/protective-ventilation-with-veno-venous-lung-assist-in-respiratory-failure-a-protocol-for-a-multicentre-randomised-controlled-trial-of-extracorporeal-carbon-dioxide-removal-in-patients-with-acute-hypoxaemic-respiratory-failure
#11
J J McNamee, M A Gillies, N A Barrett, A M Agus, R Beale, A Bentley, A Bodenham, S J Brett, D Brodie, S J Finney, A J Gordon, M Griffiths, D Harrison, C Jackson, C McDowell, C McNally, G D Perkins, W Tunnicliffe, A Vuylsteke, T S Walsh, M P Wise, D Young, D F McAuley
One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2R) can facilitate reducing tidal volumes. pRotective vEntilation with veno-venouS lung assisT (REST) is a randomised, allocation concealed, controlled, open, multicentre pragmatic trial to determine the clinical and cost-effectiveness of lower tidal volume mechanical ventilation facilitated by vv-ECCO2R in patients with acute hypoxaemic respiratory failure...
May 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/28974976/protective-effect-of-curcumin-on-lead-acetate-induced-testicular-toxicity-in-wistar-rats
#12
Sri Agus Sudjarwo, Giftania Wardani Sudjarwo, Koerniasari
In recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Curcumin has been reported to have a strong antioxidant activity. In this study, we investigated the protective effects of curcumin on lead acetate-induced testicular damage in rats. The sample used 40 male rats divided into 5 groups: negative control (rats were given daily with corn oil); positive control (rats were given daily with lead acetate 50 mg/kg BW orally once in a day for 35 days); and the treatment group (rats were given the curcumin 100 mg, 200 mg, and 400 mg/kg BW orally once in a day for 40 days, and on the 5(th) day, were given lead acetate 50 mg/kg BW one h after the curcumin administration)...
October 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28965537/strengthening-the-primary-care-workforce-to-deliver-community-case-management-for-child-health-in-rural-indonesia
#13
Agus Setiawan, Angela Dawson
Objectives The aim of the present study was to report on the implementation of community case management (CCM) to reduce infant mortality in a rural district, namely Kutai Timur, Kalimantan Indonesia.Methods An interpretive qualitative methodology was used. In-depth interviews were conducted with 18 primary healthcare workers (PHCWs), and PHCWs were observed during a consultation with mothers to gain insight into the delivery of the new protocol and workforce issues. The field notes and interview transcripts were analysed thematically...
October 2, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28947902/demineralized-freeze-dried-bovine-cortical-bone-its-potential-for-guided-bone-regeneration-membrane
#14
David B Kamadjaja, Achmad Harijadi, Pratiwi Soesilawati, Eny Wahyuni, Nurul Maulidah, Akhsanal Fauzi, Fika Rah Ayu, Roberto Simanjuntak, R Soesanto, Djodi Asmara, Andra Rizqiawan, Peter Agus, Coen Pramono
BACKGROUND: Bovine pericardium collagen membrane (BPCM) had been widely used in guided bone regeneration (GBR) whose manufacturing process usually required chemical cross-linking to prolong its biodegradation. However, cross-linking of collagen fibrils was associated with poorer tissue integration and delayed vascular invasion. OBJECTIVE: This study evaluated the potential of bovine cortical bone collagen membrane for GBR by evaluating its antigenicity potential, cytotoxicity, immune and tissue response, and biodegradation behaviors...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28918171/the-association-between-delirium-and-sarcopenia-in-older-adult-patients-admitted-to-acute-geriatrics-units-results-from-the-glisten-multicenter-observational-study
#15
Giuseppe Bellelli, Antonella Zambon, Stefano Volpato, Pasquale Abete, Lara Bianchi, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Andrea Rossi, Francesco Landi
BACKGROUND & AIMS: To date, studies assessing the relationship between sarcopenia and delirium, two of the most common geriatric syndromes, are lacking. We sought to explore this association by investigating the co-occurrence of these two conditions and the independent association between them in a population of hospitalized older adults. METHODS: Cross-sectional multicenter analysis of older adults consecutively admitted to 12 acute geriatric units (AGUs). Sarcopenia was assessed upon admission by evaluating the presence of low skeletal mass index (kg/m(2)), and either low handgrip strength or low walking speed (European Working Group on Sarcopenia in Older People, EWGSOP criteria)...
September 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28912437/voice-selectivity-in-the-temporal-voice-area-despite-matched-low-level-acoustic-cues
#16
Trevor R Agus, Sébastien Paquette, Clara Suied, Daniel Pressnitzer, Pascal Belin
In human listeners, the temporal voice areas (TVAs) are regions of the superior temporal gyrus and sulcus that respond more to vocal sounds than a range of nonvocal control sounds, including scrambled voices, environmental noises, and animal cries. One interpretation of the TVA's selectivity is based on low-level acoustic cues: compared to control sounds, vocal sounds may have stronger harmonic content or greater spectrotemporal complexity. Here, we show that the right TVA remains selective to the human voice even when accounting for a variety of acoustical cues...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890757/populations-of-rice-grain-bug-paraeuscosmetus-pallicomis-hemiptera-lygaeidae-in-weed-free-paddy-field-weedy-paddy-field-and-paddy-dykes
#17
Tamrin Abdullah, Andi Nasruddin, Nurariaty Agus
Research on the populations of rice grain bug Paraeuscosmetus pallicomis Dallas (Hemiptera: Lygaeidae) in paddy field ecosystems was performed with the aim to determine the populations of rice grain bug in weed-free paddy field, weedy paddy field, and paddy dykes. Experiment was carried out in the village of Paccellekang in the district of Patallasang of Gowa Regency in South Sulawesi, Indonesia. Observations were performed during the milky grain stage (85 days after planting), the mature grain stage (105 days after planting), and one day after harvest (115 days after transplanting)...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28868190/upward-migration-and-peroral-extrusion-of-a-peritoneal-shunt-catheter-case-report-and-review-of-the-literature
#18
Asra Al Fauzi, Wihasto Suryaningtyas, Joni Wahyuhadi, M Arifin Parenrengi, Agus Turchan, Maria C Wijaya, Michael Jonatan, Mahyudanil, Hanis Setyono
BACKGROUND: Various complications after ventriculoperitoneal (VP) shunt surgery have been reported, but peroral extrusion of peritoneal catheter is an extremely rare complication, and only 20 cases have been reported since 1987. The pathophysiology still remains unclear and the management is challenging. CASE DESCRIPTION: A 5-year-old boy presented with a catheter coming out of his mouth. The boy had a posterior fossa tumor surgery and had VP shunt insertion 1 year earlier...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28866532/sparseleap-efficient-empty-space-skipping-for-large-scale-volume-rendering
#19
Markus Hadwiger, Ali K Al-Awami, Johanna Beyer, Marco Agus, Hanspeter Pfister
Recent advances in data acquisition produce volume data of very high resolution and large size, such as terabyte-sized microscopy volumes. These data often contain many fine and intricate structures, which pose huge challenges for volume rendering, and make it particularly important to efficiently skip empty space. This paper addresses two major challenges: (1) The complexity of large volumes containing fine structures often leads to highly fragmented space subdivisions that make empty regions hard to skip efficiently...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28827971/the-potency-of-red-seaweed-eucheuma-cottonii-extracts-as-hepatoprotector-on-lead-acetate-induced-hepatotoxicity-in-mice
#20
Giftania Wardani, Nuraini Farida, Rina Andayani, Mahmiah Kuntoro, Sri Agus Sudjarwo
BACKGROUND: Lead is one of the most toxic metals, producing severe organ damage in animals and humans. Oxidative stress is reported to play an important role in lead acetate-induced liver injury. AIM: This study was carried out to investigate the role of ethanol extract of Eucheuma cottonii in protecting against lead acetate-induced hepatotoxicity in male mice. MATERIALS AND METHODS: The sample used fifty male mice which were divided into five groups: negative control (mice were given daily with Aquadest); positive control (mice were given daily with lead acetate 20 mg/kg body weight (BW) orally once in a day for 21 days); and the treatment group (mice were given E...
July 2017: Pharmacognosy Research
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