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ultrasound AND contrast media

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https://www.readbyqxmd.com/read/28700167/-relevance-of-contrast-ultrasound-with-microbubbles-in-vascular-medecine
#1
Andreas Erdmann, Barbara Ney, Adriano Alatri, Luca Calanca, Lucia Mazzolai
Application of ultrasound contrast media has become a standard in diagnostic imaging in cardiology and in the characterization of focal lesions in multiple organs, especially of the liver. In the past years there was a growing body of evidence for their usefulness in vascular medicine. The development of contrast media, microbubbles with a stabilizing envelope and filled with gaz, small enough to pass through pulmonary capillaries made real-time imaging of organ perfusion possible. Ultrasound contrast media are rapidly eliminated by exhalation and can safely be administered to patients with renal failure...
December 7, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28692762/nanoscale-ultrasound-switchable-fret-based-liposomes-for-near-infrared-fluorescence-imaging-in-optically-turbid-media
#2
Qimei Zhang, Stephen P Morgan, Melissa L Mather
A new approach for fluorescence imaging in optically turbid media centered on the use of nanoscale ultrasound-switchable FRET-based liposome contrast agents is reported. Liposomes containing lipophilic carbocyanine dyes as FRET pairs with emission wavelengths located in the near-infrared window are prepared. The efficacy of FRET and self-quenching for liposomes with a range of fluorophore concentrations is first calculated from measurement of the liposome emission spectra. Exposure of the liposomes to ultrasound results in changes in the detected fluorescent signal, the nature of which depends on the fluorophores used, detection wavelength, and the fluorophore concentration...
July 10, 2017: Small
https://www.readbyqxmd.com/read/28683759/intravenous-neutralization-of-vascular-endothelial-growth-factor-reduces-vascular-function-permeability-of-the-ovary-and-prevents-development-of-ohss-like-symptoms-in-rhesus-monkeys
#3
C V Bishop, D M Lee, O D Slayden, X Li
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with elevated serum VEGFA following chorionic gonadotropin (hCG) exposure in controlled ovarian stimulation (COS) cycles in women. In this study, we tested the effect of intravenous VEGFA neutralization on OHSS-like symptoms and vascular function in rhesus macaques during COS cycles. METHODS: Monkeys (n = 8) were treated with 3 COS protocols and assigned randomly to groups as follows: 1) COS alone (Control, n = 5); 2) COS + VEGF mAb Avastin 19 ± 5 h before hCG (Avastin pre-hCG; n = 6); 3) COS + Avastin 3-4 days post-hCG (Avastin post-hCG; n = 4); 4) COS + Simulated Early Pregnancy (SEP n = 3); or 5) COS + SEP + Avastin (SEP + Avastin n = 3)...
July 6, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28655388/ultrasound-guided-percutaneous-endovascular-treatment-of-arteriovenous-fistula-graft
#4
Boštjan Leskovar, Tjaša Furlan, Simona Poznič, Maja Potisek, Anton Adamlje, Tomaž Ključevšek
BACKGROUND: Ultrasound-guided percutaneous endovascular treatment of arteriovenous fistula (AVF) or graft failure is an alternative to radiologically-guided angioplastic methods. Its main advantages are that it can be used with open or percutaneous access, using no contrast media and no radiation. The aim of this study was to analyze the results of ultrasound-guided endovascular treatment of arteriovenous access failure. MATERIAL AND METHODS: Preoperative ultrasound was used to determine the degree of stenosis and the size of balloon used in angioplasty...
June 28, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28629621/differential-effect-of-obesity-on-prevalence-of-cardiac-and-carotid-target-organ-damage-in-hypertension-the-campania-salute-network
#5
Costantino Mancusi, Eva Gerdts, Maria Angela Losi, Andrea D'Amato, Maria Virginia Manzi, Grazia Canciello, Valentina Trimarco, Nicola De Luca, Giovanni de Simone, Raffaele Izzo
BACKGROUND: Whether increasing body mass index (BMI) is independently associated with parallel increased prevalence of hypertensive vascular and cardiac target organ damage (TOD) needs further clarification. METHODS: We analyzed 8815 hypertensive patients without prevalent cardiovascular disease, participating in the Campania Salute Network, grouped into BMI classes (normal 20-24.9kg/m(2), overweight 25-29.9kg/m(2) and obese ≥30kg/m(2)). Vascular and cardiac TOD was defined as ultrasound plaque (intima-media thickness>1...
June 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28618826/a-marchenko-equation-for-acoustic-inverse-source-problems
#6
Joost van der Neut, Jami L Johnson, Kasper van Wijk, Satyan Singh, Evert Slob, Kees Wapenaar
From acoustics to medical imaging and seismology, one strives to make inferences about the structure of complex media from acoustic wave observations. This study proposes a solution that is derived from the multidimensional Marchenko equation, to learn about the acoustic source distribution inside a volume, given a set of observations outside the volume. Traditionally, this problem has been solved by backpropagation of the recorded signals. However, to achieve accurate results through backpropagation, a detailed model of the medium should be known and observations should be collected along a boundary that completely encloses the volume of excitation...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28616535/effect-of-intravenous-infusion-of-iodinated-contrast-media-on-the-coronary-blood-flow-in-dogs
#7
Thura T Abd, Asim I Shafique, Hayder S Yasir, Jung-Hee Seo, Richard T George, Rajat Mittal, Albert C Lardo
BACKGROUND: Coronary computed tomography angiography (CCTA) is obtained using peripheral intravenous iodinated contrast agents (ICA) injection. There is continuing attempts to derive coronary physiological information like coronary blood flow (CBF) and/or fractional flow reserve from CCTA images. However, no data is available regarding the effect of peripheral intravenous injection of ICA on CBF. METHODS: A series of 4 experiments was performed using healthy mongrel dogs...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28587488/running-multiple-marathons-is-not-a-risk-factor-for-premature-subclinical-vascular-impairment
#8
Axel Pressler, Christiane Suchy, Tasja Friedrichs, Sophia Dallinger, Viola Grabs, Bernhard Haller, Martin Halle, Johannes Scherr
Background In contrast to the well-accepted benefits of moderate exercise, recent research has suggested potential deleterious effects of repeated marathon running on the cardiovascular system. We thus performed a comprehensive analysis of markers of subclinical vascular damage in a cohort of runners having finished multiple marathon races successfully. Design This was a prospective, observational study. Methods A total of 97 healthy male Munich marathon participants (mean age 44 ± 10 years) underwent detailed training history, cardiopulmonary exercise testing for assessment of peak oxygen uptake, ultrasound for assessment of intima-media-thickness as well as non-invasive assessments of ankle-brachial index, augmentation index, pulse wave velocity and reactive hyperaemia index...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28515407/comparison-of-the-outback-%C3%A2-elite-reentry-catheter-and-the-bi-directional-approach-after-failed-antegrade-approach-for-femoro-popliteal-occlusive-disease
#9
Daizo Kawasaki, Masashi Fukunaga, Tsuyoshi Nakata, Masaaki Kato, Nobukazu Ohkubo
AIM: A successful antegrade wire crossing for femoro-popliteal chronic total occlusion (FP-CTO) is still a technical challenge. We attempted to demonstrate the safety and feasibility of the OUTBACK(®) Elite reentry catheter and the bi-directional approach for failed FP-CTO cases with the antegrade approach. METHODS: Endovascular therapy for FP-CTO was performed in 219 lesions from May 2013 to December 2016 at Morinomiya Hospital. We retrospectively analyzed the data of 43 consecutive lesions which underwent endovascular therapy using the bi-directional approach with distal access and the mono-directional approach with the OUTBACK(®) Elite reentry catheter for FP-CTO lesions...
May 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28511219/-innovative-ultrasound-contrast-enhanced-ultrasound-of-the-kidneys
#10
Konrad Stock, Herbert Kübler, Tobias Maurer, Daniel Weiss, Hans-Peter Weskott, Uwe Heemann
Ultrasound examination of the kidneys with grey-scale imaging and colour Doppler ultrasound is the most common renal imaging modality. A few years ago, contrast-enhanced ultrasound (CEUS) emerged as a non-invasive perfusion imaging modality to evaluate the renal vessels and microvascularisation. These contrast media contain intravenous microbubbles (sulfur hexafluoride), which have no deleterious effect on renal function. Being free of iodine, they also pose no risk for the thyroid gland. CEUS of the kidneys is mainly used for the evaluation of renal cysts and the analysis of renal lesions suspicious for malignancy...
April 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28380969/photoacoustics-and-speed-of-sound-dual-mode-imaging-with-a-long-depth-of-field-by-using-annular-ultrasound-array
#11
Qiuning Ding, Chao Tao, Xiaojun Liu
Speed-of-sound and optical absorption reflect the structure and function of tissues from different aspects. A dual-mode microscopy system based on a concentric annular ultrasound array is proposed to simultaneously acquire the long depth-of-field images of speed-of-sound and optical absorption of inhomogeneous samples. First, speed-of-sound is decoded from the signal delay between each element of the annular array. The measured speed-of-sound could not only be used as an image contrast, but also improve the resolution and accuracy of spatial location of photoacoustic image in inhomogeneous acoustic media...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28317160/contrast-enhanced-ultrasonography-vs-b-mode-ultrasound-for-visualization-of-intima-media-thickness-and-detection-of-plaques-in-human-carotid-arteries
#12
Benoy N Shah, Navtej S Chahal, Jaspal S Kooner, Roxy Senior
BACKGROUND: Carotid intima-media thickness (IMT) and plaque are recognized markers of increased risk for cerebrovascular events. Accurate visualization of the IMT and plaques is dependent upon image quality. Ultrasound contrast agents improve image quality during echocardiography-this study assessed whether contrast-enhanced ultrasound (CEUS) improves carotid IMT visualization and plaque detection in an asymptomatic population. METHODS & RESULTS: Individuals free from known cardiovascular disease, enrolled in a community study, underwent B-mode and CEUS carotid imaging...
May 2017: Echocardiography
https://www.readbyqxmd.com/read/28273102/age-related-differences-in-skeletal-muscle-microvascular-response-to-exercise-as-detected-by-contrast-enhanced-ultrasound-ceus
#13
Wulf Hildebrandt, Hans Schwarzbach, Anita Pardun, Lena Hannemann, Björn Bogs, Alexander M König, Andreas H Mahnken, Olaf Hildebrandt, Ulrich Koehler, Ralf Kinscherf
BACKGROUND: Aging involves reductions in exercise total limb blood flow and exercise capacity. We hypothesized that this may involve early age-related impairments of skeletal muscle microvascular responsiveness as previously reported for insulin but not for exercise stimuli in humans. METHODS: Using an isometric exercise model, we studied the effect of age on contrast-enhanced ultrasound (CEUS) parameters, i.e. microvascular blood volume (MBV), flow velocity (MFV) and blood flow (MBF) calculated from replenishment of Sonovue contrast-agent microbubbles after their destruction...
2017: PloS One
https://www.readbyqxmd.com/read/28266925/an-iterative-fullwave-simulation-approach-to-multiple-scattering-in-media-with-randomly-distributed-microbubbles
#14
Aditya Joshi, Brooks D Lindsey, Paul A Dayton, Gianmarco Pinton, Marie Muller
Ultrasound contrast agents (UCA), such as microbubbles, enhance the scattering properties of blood, which is otherwise hypoechoic. The multiple scattering interactions of the acoustic field with UCA are poorly understood due to the complexity of the multiple scattering theories and the nonlinear microbubble response. The majority of bubble models describe the behavior of UCA as single, isolated microbubbles suspended in infinite medium. Multiple scattering models such as the independent scattering approximation can approximate phase velocity and attenuation for low scatterer volume fractions...
May 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28258771/acoustic-behavior-of-halobacterium-salinarum-gas-vesicles-in-the-high-frequency-range-experiments-and-modeling
#15
Emmanuel Cherin, Johan M Melis, Raymond W Bourdeau, Melissa Yin, Dennis M Kochmann, F Stuart Foster, Mikhail G Shapiro
Gas vesicles (GVs) are a new and unique class of biologically derived ultrasound contrast agents with sub-micron size whose acoustic properties have not been fully elucidated. In this study, we investigated the acoustic collapse pressure and behavior of Halobacterium salinarum gas vesicles at transmit center frequencies ranging from 12.5 to 27.5 MHz. The acoustic collapse pressure was found to be above 550 kPa at all frequencies, nine-fold higher than the critical pressure observed under hydrostatic conditions...
May 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28255790/-contrast-enhanced-ultrasound-ceus-of-the-liver-critical-evaluation-of-use-in-clinical-routine-diagnostics
#16
K Müller-Peltzer, J Rübenthaler, M Reiser, D-A Clevert
CLINICAL/METHODICAL ISSUE: Focal liver lesions are common incidental findings in abdominal ultrasound diagnostics. STANDARD RADIOLOGICAL METHODS: Characterization of focal liver lesions solely based on b‑mode and color duplex is not feasible in all cases. METHODICAL INNOVATIONS: Using contrast-enhanced ultrasound (CEUS) it is possible to dynamically visualize the vascularization of focal liver lesions, which enables the characterization of benign and malignant liver tumors...
March 2, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28248380/selection-of-the-tagged-photons-by-off-axis-heterodyne-holography-in-ultrasound-modulated-optical-tomography
#17
M Gross
Ultrasound-modulated optical tomography (UOT) is a technique that images optical contrast deep inside scattering media. Heterodyne holography is a promising tool that is able to detect UOT-tagged photons with high efficiency. In this work, we describe theoretically the detection of the tagged photon in heterodyne holography-based UOT, show how to filter the untagged photon, and discuss the effect of shot noise. The discussion also considers speckle decorrelation. We show that optimal detection sensitivity can be reached, if the frame exposure time of the camera used to perform the holographic detection is on the order of the decorrelation time...
March 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28121732/icnirp-statement-on-diagnostic-devices-using-non-ionizing-radiation-existing-regulations-and-potential-health-risks
#18
(no author information available yet)
Use of non-ionizing radiation (NIR) for diagnostic purposes allows non-invasive assessment of the structure and function of the human body and is widely employed in medical care. ICNIRP has published previous statements about the protection of patients during medical magnetic resonance imaging (MRI), but diagnostic methods using other forms of NIR have not been considered. This statement reviews the range of diagnostic NIR devices currently used in clinical settings; documents the relevant regulations and policies covering patients and health care workers; reviews the evidence around potential health risks to patients and health care workers exposed to diagnostic NIR; and identifies situations of high NIR exposure from diagnostic devices in which patients or health care workers might not be adequately protected by current regulations...
2017: Health Physics
https://www.readbyqxmd.com/read/28039821/selecting-the-best-aop-for-isoxazolyl-penicillins-degradation-as-a-function-of-water-characteristics-effects-of-ph-chemical-nature-of-additives-and-pollutant-concentration
#19
Paola Villegas-Guzman, Javier Silva-Agredo, Oscar Florez, Ana L Giraldo-Aguirre, Cesar Pulgarin, Ricardo A Torres-Palma
To provide new insights toward the selection of the most suitable AOP for isoxazolyl penicillins elimination, the degradation of dicloxacillin, a isoxazolyl penicillin model, was studied using different advanced oxidation processes (AOPs): ultrasound (US), photo-Fenton (UV/H2O2/Fe(2+)) and TiO2 photocatalysis (UV/TiO2). Although all processes achieved total removal of the antibiotic and antimicrobial activity, and increased the biodegradability level of the solutions, significant differences concerning the mineralization extend, the pH of the solution, the pollutant concentration and the chemical nature of additives were found...
April 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28017911/apelin-concentrations-are-associated-with-altered-atherosclerotic-plaque-stability-mediator-levels-and-atherosclerosis-in-rheumatoid-arthritis
#20
Sule Gunter, Ahmed Solomon, Linda Tsang, Angela J Woodiwiss, Chanel Robinson, Aletta M E Millen, Gavin R Norton, Patrick H Dessein
BACKGROUND AND AIMS: Apelin-APJ signaling reduces cardiovascular disease (CVD) risk. In rheumatoid arthritis (RA), the atherosclerosis burden and plaque vulnerability to rupture are increased. We explored relationships between apelin concentrations and subclinical CVD in RA. METHODS: Apelin levels were measured in 235 (114 black, 121 white) RA patients. Associations between apelin concentrations and ultrasound determined carotid artery intima-media thickness (cIMT) and plaque, and levels of matrix metalloproteinase (MMP)-2 and -9 that mediate plaque stability and vulnerability respectively, were identified in confounder adjusted multivariate regression analysis...
January 2017: Atherosclerosis
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