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Choline nutrition

Seu Ping Guiraud, Ivan Montoliu, Laeticia Da Silva, Loïc Dayon, Antonio Núñez Galindo, John Corthésy, Martin Kussmann, Francois-Pierre Martin
The methionine cycle is a key pathway contributing to the regulation of human health, with well-established involvement in cardiovascular diseases and cognitive function. Changes in one-carbon cycle metabolites have also been associated with mild cognitive decline, vascular dementia, and Alzheimer's disease. Today, there is no single analytical method to monitor both metabolites and co-factors of the methionine cycle. To address this limitation, we here report for the first time a new method for the simultaneous quantitation of 17 metabolites in the methionine cycle, which are homocysteic acid, taurine, serine, cysteine, glycine, homocysteine, riboflavin, methionine, pyridoxine, cystathionine, pyridoxamine, S-adenosylhomocysteine, S-adenosylmethionine, betaine, choline, dimethylglycine, and 5-methyltetrahydrofolic acid...
October 18, 2016: Analytical and Bioanalytical Chemistry
Jordi Mayneris-Perxachs, David T Bolick, Joy Leng, Greg L Medlock, Glynis L Kolling, Jason A Papin, Jonathan R Swann, Richard L Guerrant
BACKGROUND: Environmental enteropathy, which is linked to undernutrition and chronic infections, affects the physical and mental growth of children in developing areas worldwide. Key to understanding how these factors combine to shape developmental outcomes is to first understand the effects of nutritional deficiencies on the mammalian system including the effect on the gut microbiota. OBJECTIVE: We dissected the nutritional components of environmental enteropathy by analyzing the specific metabolic and gut-microbiota changes that occur in weaned-mouse models of zinc or protein deficiency compared with well-nourished controls...
October 12, 2016: American Journal of Clinical Nutrition
Yunfei Yuan, Yupeng Zhao, Jiali Yang, Yueming Jiang, Fei Lu, Yongxia Jia, Bao Yang
Banana is a tropical fruit widely accepted by people over the world. Its chemical composition is critical for its organoleptic properties and nutritional value. In this work, the metabolite changes during postharvest senescence were investigated using NMR spectroscopy. The 1D and 2D NMR spectroscopic information revealed the primary and secondary metabolites in banana fruit, including organic acids, amino acids, carbohydrates and phenolics. Bananas at five senescence stages showed similar chemical profiles, but the levels of the individual compounds varied to a large extent...
March 1, 2017: Food Chemistry
S K Jaiswal, K K Sukla, A Chauhan, A R Lakhotia, A Kumar, A K Rai
BACKGROUND/OBJECTIVES: Choline is an essential nutrient involved in one-carbon metabolism, but its role in mechanisms underlying meiotic non-disjunction is poorly known. The relationship between folate-homocysteine metabolic pathway gene polymorphism and Down syndrome (DS) risk has been widely analyzed, but there are limited reports on its correlation with choline metabolism. In the present case-control association study, we investigated the relationship of three single-nucleotide polymorphisms (SNPs) (phosphatidylethanolamine N-methyltransferase (PEMT) rs12325817, choline dehydrogenase (CHDH) rs12676 and homocysteine methyltransferase (BHMT) rs3733890) of choline metabolism with risk for DS...
September 28, 2016: European Journal of Clinical Nutrition
G Jayaprakash, M Sathiyabarathi, M Arokia Robert, T Tamilmani
Choline is a vitamin-like substance it has multi-function in animal production, reproduction, and health. The transition period is most crucial stage in lactation cycle of dairy cows due to its association with negative hormonal and energy balances. Unfortunately, unprotected choline easily degrades in the rumen; therefore, choline added to the diet in a rumen-protected form. The use of rumen-protected choline (RPC) is a preventive measurement for the fatty liver syndrome and ketosis; may improve milk production as well as milk composition and reproduction parameters...
August 2016: Veterinary World
Flaminia Cesare Marincola, Sara Corbu, Milena Lussu, Antonio Noto, Angelica Dessì, Stefania Longo, Elisa Civardi, Francesca Garofoli, Beatrice Grenci, Elisa Mongini, Andrea Budelli, Alessia Grinzato, Francesca Fasano, Vassilios Fanos, Mauro Stronati
NMR-based metabolomics was used to compare the metabolic urinary profiles of exclusively breast-fed term infants (n = 11) with those of a double-blinded controlled trial with 49 formula-fed term newborns randomized to receive either an infant formula enriched by functional ingredients (n = 24) or a standard formula (n = 25). Anthropometric measurements and urine samples were taken at enrollment (within the first month of life), at around 60 days of life, and at the end of study period (average age of 130 days)...
October 7, 2016: Journal of Proteome Research
Anna C Croce, Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Valeria Maria Piccolini, Vittorio Bertone, Giovanni Bottiroli, Mariapia Vairetti
Liver tissue autofluorescence (AF) has been characterized in two models with a different potential to undergo disease progression to steatohepatitis: Wistar rats, administered with a methionine, choline deficient diet (MCD), and Zucker (fa/fa) rats, homozygous for a spontaneous mutation of leptin receptor. AF spectra were recorded from liver tissue cryostatic sections by microspectrofluorometry, under 366nm excitation. Curve fitting analysis was used to estimate the contribution of different endogenous fluorophores (EFs) to the overall AF emission: i) fluorescing fatty acids, a fraction of liver lipids up to now poorly considered and complicated to detect by conventional procedures; ii) lipofuscin-like lipopigments, biomarkers of oxidizing events; iii) NAD(P)H and flavins, biomarkers of energy metabolism and tissue redox state...
September 12, 2016: Journal of Photochemistry and Photobiology. B, Biology
Z Zhou, O Bulgari, M Vailati-Riboni, E Trevisi, M A Ballou, F C Cardoso, D N Luchini, J J Loor
The immunometabolic status of peripartal cows is altered due to changes in liver function, inflammation, and oxidative stress. Nutritional management during this physiological state can affect the biological components of immunometabolism. The objectives of this study were to measure concentrations of biomarkers in plasma, liver tissue, and milk, and also polymorphonuclear leukocyte function to assess the immunometabolic status of cows supplemented with rumen-protected methionine (MET) or choline (CHOL). Forty-eight multiparous Holstein cows were used in a randomized complete block design with 2 × 2 factorial arrangement of MET (Smartamine M, Adisseo NA) and CHOL (ReaShure, Balchem Inc...
August 31, 2016: Journal of Dairy Science
Matthew P Hanley, Krishna Kadaveru, Christine Perret, Charles Giardina, Daniel W Rosenberg
The role of folate one-carbon metabolism in colorectal cancer development is controversial, with nutritional intervention studies producing conflicting results. It has been reported that Apc(Min/+) mice maintained on a diet deficient in the methyl donors folic acid, methionine, choline, and vitamin B12, and supplemented with homocysteine, show a greater than 95% reduction in intestinal tumor development. The present study extends these findings and shows that tumor protection afforded by dietary methyl donor deficiency (MDD) is long-lasting...
October 2016: Cancer Prevention Research
Sara Pauwels, Radu Corneliu Duca, Roland Devlieger, Kathleen Freson, Dany Straetmans, Erik Van Herck, Inge Huybrechts, Gurdun Koppen, Lode Godderis
It is still unclear to which extent methyl-group intake during pregnancy can affect maternal global DNA (hydroxyl)methylation. Pregnancy methylation profiling and its link with methyl-group intake in a healthy population could enhance our understanding of the development of pregnancy related disorders. One hundred forty-eight women were enrolled in the MANOE (MAternal Nutrition and Offspring's Epigenome) study. Thiry-four women were enrolled before pregnancy and 116 during the first trimester of pregnancy. Global DNA (hydroxy)methylation in blood using LC-MS/MS and dietary methyl-group intake (methionine, folate, betaine, and choline) using a food-frequency questionnaire were estimated pre-pregnancy, during each trimester, and at delivery...
2016: Nutrients
Feifei Sun, Yangchun Cao, Chuanjiang Cai, Shengxiang Li, Chao Yu, Junhu Yao
This study investigated the effects of rumen-protected methionine (RPM) and rumen-protected choline (RPC) on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum...
2016: PloS One
Zhi Luo, Chuan-Chuan Wei, Han-Mei Ye, Hai-Ping Zhao, Yu-Feng Song, Kun Wu
The present experiment was conducted to determine the effect and mechanism of dietary choline levels on growth performance and lipid deposition of yellow catfish Pelteobagrus fulvidraco. Dietary choline was included at three levels of 239.2 (control (without extra choline addition), 1156.4 and 2273.6mg choline per kg diet, respectively) and fed to yellow catfish (mean initial weight: 3.45±0.02g. mean±standard errors of mean (SEM)) for 8weeks. Fish fed the diet containing 1156.4mgkg(-1) choline showed the higher weight gain (WG), specific growth rate (SGR) and feed intake (FI), but the lower feed conversion rate (FCR), than those in control and highest choline group...
July 27, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Tilman Kühn, Sabine Rohrmann, Disorn Sookthai, Theron Johnson, Verena Katzke, Rudolf Kaaks, Arnold von Eckardstein, Daniel Müller
BACKGROUND: Circulating trimethylamine-N-oxide (TMAO) has been implicated in the development of cardiovascular and chronic kidney diseases (CKD). However, while higher TMAO levels have been associated with increased risks of cardiovascular or renal events in first prospective studies, it remained unclear how much plasma TMAO concentrations vary over time. METHODS: We measured fasting plasma levels of TMAO and two of its precursors, betaine and choline by LC-MS, in two samples of 100 participants of the European Investigation into Cancer and Nutrition (EPIC)-Heidelberg study (age range: 47-80 years, 50% female) that were collected 1 year apart, and assessed their intra-individual variation by Spearman's correlation coefficients (ρ)...
July 22, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Daoyuan Ren, Yafei Liu, Yan Zhao, Xingbin Yang
The involvement of choline and its metabolite trimethylamine-N-oxide (TMAO) in endothelial dysfunction and atherosclerosis has been repeatedly confirmed. Phloretin, a dihydrochalcone flavonoid usually present in apples, possesses a variety of biological activities including vascular nutrition. This study was designed to investigate whether phloretin could alleviate or prevent high choline-induced vascular endothelial dysfunction and liver injury in mice. Mice were provided with 3% high choline water and given phloretin orally daily for 10 weeks...
August 2016: Food and Chemical Toxicology
Awais Ahmad, Salem S Alghamdi, Kaiser Mahmood, Muhammad Afzal
Fenugreek is one of the oldest medicinal plants with exceptional medicinal and nutritional profile. Fenugreek seeds contain a substantial amount of fiber, phospholipids, glycolipids, oleic acid, linolenic acid, linoleic acid, choline, vitamins A, B1, B2, C, nicotinic acid, niacin, and many other functional elements. It may grow well under diverse and a wide range of conditions; it is moderately tolerant to drought and salinity, and can even be grown on marginal lands in profitable way. Owing to these characteristics and heavy metal remediation potential, fenugreek may well fit several cropping systems...
March 2016: Saudi Journal of Biological Sciences
Xiu-Ju Zhao, Yu-Lian Chen, Bing Fu, Wen Zhang, Zhiguo Liu, Hexian Zhuo
BACKGROUND: Understanding the metabolic and transcription basis of pumpkin seed oil (PSO) intervention on metabolic disease (MD) is essential to daily nutrition and health. RESULTS: Here, we analyzed the liver metabolic variations from Wistar rats with normal diet (CON), high fat diet (HFD) and high fat plus PSO diet (PSO) to establish the relationship between the liver metabolite compositions/transcript profile and the effects of PSO on MD. By using proton nuclear magnetic resonance spectroscopy accompanied with multivariate data analysis, we found that compared with CON, the HFD rats showed clear dysfunctions of choline metabolism, glucose metabolism, nucleotide and amino acid metabolisms...
June 13, 2016: Journal of the Science of Food and Agriculture
Brodie A Parent, Max Seaton, Ravi F Sood, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Grant E O'Keefe
IMPORTANCE: Metabolomics is the broad and parallel study of metabolites within an organism and provides a contemporaneous snapshot of physiologic state. Use of metabolomics in the clinical setting may help achieve precision medicine for those who have experienced trauma, where diagnosis and treatment are tailored to the individual patient. OBJECTIVE: To examine whether metabolomics can (1) distinguish healthy volunteers from trauma patients and (2) quantify changes in catabolic metabolites over time after injury...
July 20, 2016: JAMA Surgery
Ulrik K Sundekilde, Eimear Downey, James A O'Mahony, Carol-Anne O'Shea, C Anthony Ryan, Alan L Kelly, Hanne C Bertram
Human milk is the ideal nutrition source for healthy infants during the first six months of life and a detailed characterisation of the composition of milk from mothers that deliver prematurely (<37 weeks gestation), and of how human milk changes during lactation, would benefit our understanding of the nutritional requirements of premature infants. Individual milk samples from mothers delivering prematurely and at term were collected. The human milk metabolome, established by nuclear magnetic resonance (NMR) spectroscopy, was influenced by gestational and lactation age...
2016: Nutrients
Richard D Semba, Michelle Shardell, Fayrouz A Sakr Ashour, Ruin Moaddel, Indi Trehan, Kenneth M Maleta, M Isabel Ordiz, Klaus Kraemer, Mohammed A Khadeer, Luigi Ferrucci, Mark J Manary
BACKGROUND: Stunting affects about one-quarter of children under five worldwide. The pathogenesis of stunting is poorly understood. Nutritional interventions have had only modest effects in reducing stunting. We hypothesized that insufficiency in essential amino acids may be limiting the linear growth of children. METHODS: We used a targeted metabolomics approach to measure serum amino acids, glycerophospholipids, sphingolipids, and other metabolites using liquid chromatography-tandem mass spectrometry in 313 children, aged 12-59months, from rural Malawi...
April 2016: EBioMedicine
Jason L Robinson, Robert F Bertolo
The metabolic demand for methionine is great in neonates. Indeed, methionine is the only indispensable sulfur amino acid and is required not only for protein synthesis and growth but is also partitioned to a greater extent to transsulfuration for cysteine and taurine synthesis and to >50 transmethylation reactions that serve to methylate DNA and synthesize metabolites, including creatine and phosphatidylcholine. Therefore, the pediatric methionine requirement must accommodate the demands of rapid protein turnover as well as vast nonprotein demands...
May 2016: Advances in Nutrition
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