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Mitsuru Toda

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https://www.readbyqxmd.com/read/27020040/differential-effects-of-adipose-tissue-stromal-cells-on-the-apoptosis-growth-and-invasion-of-bladder-urothelial-carcinoma-between-the-superficial-and-invasive-types
#1
Maki Kawasaki-Nanri, Shigehisa Aoki, Kazuyoshi Uchihashi, Mihoko Yamamoto, Kazuma Udo, Aki Nishijima-Matsunobu, Nahoko Kakihara, Mitsuru Noguchi, Jiro Uozumi, Shuji Toda
OBJECTIVES: To clarify the interaction between adipose tissue stromal cells and bladder cancer cells. METHODS: Superficial (RT4) and invasive (EJ) urothelial carcinoma cells were cultured on adipose tissue stromal cell-embedded or non-embedded collagen gel. Cells were analyzed by immunohistochemistry, western blot and real-time reverse transcription polymerase chain reaction. RESULTS: Adipose tissue stromal cells inhibited growth of RT4, while they promoted the apoptosis...
June 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/26981628/effectiveness-of-a-mobile-short-message-service-based-disease-outbreak-alert-system-in-kenya
#2
Mitsuru Toda, Ian Njeru, Dejan Zurovac, Shikanga O-Tipo, David Kareko, Matilu Mwau, Kouichi Morita
We conducted a randomized, controlled trial to test the effectiveness of a text-messaging system used for notification of disease outbreaks in Kenya. Health facilities that used the system had more timely notifications than those that did not (19.2% vs. 2.6%), indicating that technology can enhance disease surveillance in resource-limited settings.
April 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/26452625/the-affordable-medicines-facility-malaria-amfm-are-remote-areas-benefiting-from-the-intervention
#3
Yazoume Ye, Fred Arnold, Abdisalan Noor, Marilyn Wamukoya, John Amuasi, Samuel Blay, Blessing Mberu, Ruilin Ren, Catherine Kyobutungi, Frederick Wekesah, Hellen Gatakaa, Mitsuru Toda, Julius Njogu, Illah Evance, Kathryn O'Connell, Tanya Shewchuk, Sarah Thougher, Andrea Mann, Barbara Willey, Catherine Goodman, Kara Hanson
BACKGROUND: To assess the availability, price and market share of quality-assured artemisinin-based combination therapy (QAACT) in remote areas (RAs) compared with non-remote areas (nRAs) in Kenya and Ghana at end-line of the Affordable Medicines Facility-malaria (AMFm) intervention. METHODS: Areas were classified by remoteness using a composite index computed from estimated travel times to three levels of service centres. The index was used to five categories of remoteness, which were then grouped into two categories of remote and non-remote areas...
October 9, 2015: Malaria Journal
https://www.readbyqxmd.com/read/26325687/the-first-nationwide-survey-and-genetic-analyses-of-bardet-biedl-syndrome-in-japan
#4
Makito Hirano, Wataru Satake, Kenji Ihara, Ikuya Tsuge, Shuji Kondo, Ken Saida, Hiroyuki Betsui, Kazuhiro Okubo, Hikaru Sakamoto, Shuichi Ueno, Yasushi Ikuno, Ryu Ishihara, Hiromi Iwahashi, Mitsuru Ohishi, Toshiyuki Mano, Toshihide Yamashita, Yutaka Suzuki, Yusaku Nakamura, Susumu Kusunoki, Tatsushi Toda
Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder characterized by central obesity, mental impairment, rod-cone dystrophy, polydactyly, hypogonadism in males, and renal abnormalities. The causative genes have been identified as BBS1-19. In Western countries, this disease is often reported, but remains undiagnosed in many patients until later in life, while only a few patients with no mutations identified have been reported in Japan. We thus conducted the first nationwide survey of BBS in Japan by sending questionnaires to 2,166 clinical departments with board-certified specialists and found 7 patients with clinically definite BBS...
2015: PloS One
https://www.readbyqxmd.com/read/26318752/fluid-dwell-impact-induces-peritoneal-fibrosis-in-the-peritoneal-cavity-reconstructed-in-vitro
#5
Shigehisa Aoki, Mitsuru Noguchi, Toshiaki Takezawa, Satoshi Ikeda, Kazuyoshi Uchihashi, Hiroyuki Kuroyama, Tomoyuki Chimuro, Shuji Toda
Peritoneal fluid dwell impacts the peritoneum by creating an abnormal physiological microenvironment. Little is known about the precise effects of fluid dwell on the peritoneum, and no adequate in vitro models to analyze the impact of fluid dwell have been established. In this study, we developed a peritoneal fluid dwell model combined with an artificial peritoneal cavity and fluid stirring generation system to clarify the effects of different dwelling solutions on the peritoneum over time. To replicate the peritoneal cavity, we devised a reconstructed peritoneal cavity utilizing a mesothelial layer, endothelial layer, and collagen membrane chamber...
March 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/25708686/efficacy-and-safety-of-fosphenytoin-for-benign-convulsions-with-mild-gastroenteritis
#6
Mika Nakazawa, Soichiro Toda, Shinpei Abe, Mitsuru Ikeno, Ayuko Igarashi, Eri Nakahara, Shintaro Yamashita, Shinichi Niijima, Toshiaki Shimizu, Akihisa Okumura
OBJECTIVE: To clarify the efficacy and safety of fosphenytoin for seizures in children with benign convulsions and mild gastroenteritis. METHODS: Using the mailing list of the Annual Zao Conference on Pediatric Neurology, we recruited patients who met the following criteria: (1) clinical diagnosis of benign convulsions with mild gastroenteritis and (2) treatment with intravenous fosphenytoin. Benign convulsions with mild gastroenteritis were defined as a condition of (a) seizures associated with gastroenteritis without electrolyte imbalance, hypoglycemia, or dehydration in patients (b) between 6 months and 3 years of age with (c) no preexisting neurological disorders, (d) no impaired consciousness, and (e) a body temperature less than 38...
October 2015: Brain & Development
https://www.readbyqxmd.com/read/24837638/implementation-of-patient-charges-at-primary-care-facilities-in-kenya-implications-of-low-adherence-to-user-fee-policy-for-users-and-facility-revenue
#7
Antony Opwora, Evelyn Waweru, Mitsuru Toda, Abdisalan Noor, Tansy Edwards, Greg Fegan, Sassy Molyneux, Catherine Goodman
With user fees now seen as a major hindrance to universal health coverage, many countries have introduced fee reduction or elimination policies, but there is growing evidence that adherence to reduced fees is often highly imperfect. In 2004, Kenya adopted a reduced and uniform user fee policy providing fee exemptions to many groups. We present data on user fee implementation, revenue and expenditure from a nationally representative survey of Kenyan primary health facilities. Data were collected from 248 randomly selected public health centres and dispensaries in 2010, comprising an interview with the health worker in charge, exit interviews with curative outpatients, and a financial record review...
May 2015: Health Policy and Planning
https://www.readbyqxmd.com/read/24239596/transcription-analysis-of-two-eomesodermin-genes-in-lymphocyte-subsets-of-two-teleost-species
#8
Fumio Takizawa, Kyosuke Araki, Maki Ohtani, Hideaki Toda, Yasutaka Saito, Veronica Soto Lampe, Johannes Martinus Dijkstra, Mitsuru Ototake, Tadaaki Moritomo, Teruyuki Nakanishi, Uwe Fischer
Eomesodermin (Eomes), a T-box transcription factor, is a key molecule associated with function and differentiation of CD8(+) T cells and NK cells. Previously, two teleost Eomes genes (Eomes-a and -b), which are located on different chromosomes, were identified and shown to be expressed in zebrafish lymphocytes. For the present study, we identified these genes in rainbow trout and ginbuna crucian carp. Deduced Eomes-a and -b amino acid sequences in both fish species contain a highly conserved T-box DNA binding domain...
January 2014: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/24197067/epithelial-to-mesenchymal-transition-and-slit-function-of-mesothelial-cells-are-regulated-by-the-cross-talk-between-mesothelial-cells-and-endothelial-cells
#9
Shigehisa Aoki, Toshiaki Takezawa, Ayumi Oshikata-Miyazaki, Satoshi Ikeda, Hiroyuki Kuroyama, Tomoyuki Chimuro, Yuji Oguchi, Mitsuru Noguchi, Yutaka Narisawa, Shuji Toda
Peritoneal dysfunction is a major factor leading to treatment failure of peritoneal dialysis (PD). However, the precise mechanism of the peritoneal diffusion changes related to PD remains to be elucidated. To this end, we have established a novel peritoneal diffusion model in vitro, which consists of a three-dimensional culture system using a collagen vitrigel membrane chamber and a fluid-stream generation system. This artificial peritoneal model revealed that high-glucose culture medium and fluid flow stress promoted the epithelial-mesenchymal transition (EMT) process of mesothelial cells and that endothelial cells inhibited this mesothelial EMT process...
January 1, 2014: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/24107094/are-health-facility-management-committees-in-kenya-ready-to-implement-financial-management-tasks-findings-from-a-nationally-representative-survey
#10
Evelyn Waweru, Antony Opwora, Mitsuru Toda, Greg Fegan, Tansy Edwards, Catherine Goodman, Sassy Molyneux
BACKGROUND: Community participation in peripheral public health facilities has in many countries focused on including community representatives in Health Facility Management Committees (HFMCs). In Kenya, HFMC roles are being expanded with the phased implementation of the Health Sector Services Fund (HSSF). Under HSSF, HFMCs manage facility funds which are dispersed directly from central level into facility bank accounts. We assessed how prepared HFMCs were to undertake this new role in advance of HSSF roll out, and considered the implications for Kenya and other similar settings...
October 10, 2013: BMC Health Services Research
https://www.readbyqxmd.com/read/23526130/adipose-tissue-behavior-is-distinctly-regulated-by-neighboring-cells-and-fluid-flow-stress-a-possible-role-of-adipose-tissue-in-peritoneal-fibrosis
#11
Shigehisa Aoki, Kazuma Udo, Hiroyuki Morimoto, Satoshi Ikeda, Toshiaki Takezawa, Kazuyoshi Uchihashi, Aki Nishijima-Matsunobu, Mitsuru Noguchi, Hajime Sugihara, Shuji Toda
Adipose tissue, together with the mesothelial layer and microvessels, is a major component of the mesenteric peritoneum, and the mesenterium is a target site for peritoneal fibrosis. Adipose tissue has been speculated to play a role in peritoneal dialysis (PD)-related fibrosis, but the precise cellular kinetics of adipose tissue during this process remain to be determined. To clarify this critical issue, we analyzed the kinetics of adipose tissue using a novel peritoneal reconstruction model in which the effects of mesothelial cells or endothelial cells could be identified...
September 2013: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/23236992/analyzing-the-equity-of-public-primary-care-provision-in-kenya-variation-in-facility-characteristics-by-local-poverty-level
#12
Mitsuru Toda, Antony Opwora, Evelyn Waweru, Abdisalan Noor, Tansy Edwards, Greg Fegan, Catherine Molyneux, Catherine Goodman
INTRODUCTION: Equitable access to health care is a key health systems goal, and is a particular concern in low-income countries. In Kenya, public facilities are an important resource for the poor, but little is known on the equity of service provision. This paper assesses whether poorer areas have poorer health services by investigating associations between public facility characteristics and the poverty level of the area in which the facility is located. METHODS: Data on facility characteristics were collected from a nationally representative sample of public health centers and dispensaries across all 8 provinces in Kenya...
December 13, 2012: International Journal for Equity in Health
https://www.readbyqxmd.com/read/23079589/helium-cooling-and-spinning-dynamic-nuclear-polarization-for-sensitivity-enhanced-solid-state-nmr-at-14-t-and-30-k
#13
Yoh Matsuki, Keisuke Ueda, Toshitaka Idehara, Ryosuke Ikeda, Isamu Ogawa, Shinji Nakamura, Mitsuru Toda, Takahiro Anai, Toshimichi Fujiwara
We describe a (1)H polarization enhancement via dynamic nuclear polarization (DNP) at very low sample temperature T≈30 K under magic-angle spinning (MAS) conditions for sensitivity-enhanced solid-state NMR measurement. Experiments were conducted at a high external field strength of 14.1 T. For MAS DNP experiments at T<90 K, a new probe system using cold helium gas for both sample-cooling and -spinning was developed. The novel system can sustain a low sample temperature between 30 and 90K for a period of time >10 h under MAS at ν(R)≈3 kHz with liquid He consumption of ≈6 L/h...
December 2012: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/22927782/the-effectiveness-of-liraglutide-in-nonalcoholic-fatty-liver-disease-patients-with-type-2-diabetes-mellitus-compared-to-sitagliptin-and-pioglitazone
#14
COMPARATIVE STUDY
Takamasa Ohki, Akihiro Isogawa, Masahiko Iwamoto, Mitsuru Ohsugi, Haruhiko Yoshida, Nobuo Toda, Kazumi Tagawa, Masao Omata, Kazuhiko Koike
BACKGROUND. Liraglutide leading to improve not only glycaemic control but also liver inflammation in non-alcoholic fatty liver disease (NAFLD) patients. AIMS. The aim of this study is to elucidate the effectiveness of liraglutide in NAFLD patients with type 2 diabetes mellitus (T2DM) compared to sitagliptin and pioglitazone. METHODS. We retrospectively enrolled 82 Japanese NAFLD patients with T2DM and divided into three groups (liraglutide: N = 26, sitagliptin; N = 36, pioglitazone; N = 20). We compared the baseline characteristics, changes of laboratory data and body weight...
2012: TheScientificWorldJournal
https://www.readbyqxmd.com/read/22849990/-remission-of-lymphomatosis-cerebri-induced-by-corticosteroid-and-high-doses-intravenous-methotrexate
#15
Mitsuru Watanabe, Hitoshi Satoi, Yuki Takahashi, Namiko Nishida, Hiroki Toda, Sadayuki Matsumoto
Lymphomatosis cerebri (LC) is a rare form of primary central nervous system lymphoma characterized by subacute progressive dementia and unsteady gait. MRI study of LC typically reveals diffuse leukoencephalopathy without contrast enhancement. The clinical presentation and MRI features of LC can resemble infectious, inflammatory, toxic or vascular leukoencephalopathy. Hence diagnosis of LC is easily mistaken for other, more common diseases. In this report, we present a case of a 55-year-old man presenting with subacute progressive dementia and ataxic gait...
2012: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/22120632/prolonged-effect-of-fluid-flow-stress-on-the-proliferative-activity-of-mesothelial-cells-after-abrupt-discontinuation-of-fluid-streaming
#16
Shigehisa Aoki, Satoshi Ikeda, Toshiaki Takezawa, Tomoya Kishi, Junichi Makino, Kazuyoshi Uchihashi, Aki Matsunobu, Mitsuru Noguchi, Hajime Sugihara, Shuji Toda
Encapsulating peritoneal sclerosis (EPS) often develops after transfer to hemodialysis and transplantation. Both termination of peritoneal dialysis (PD) and transplantation-related factors are risks implicated in post-PD development of EPS, but the precise mechanism of this late-onset peritoneal fibrosis remains to be elucidated. We previously demonstrated that fluid flow stress induced mesothelial proliferation and epithelial-mesenchymal transition via mitogen-activated protein kinase (MAPK) signaling. Therefore, we speculated that the prolonged bioactive effect of fluid flow stress may affect mesothelial cell kinetics after cessation of fluid streaming...
December 16, 2011: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/21272597/conservation-of-characteristics-and-functions-of-cd4-positive-lymphocytes-in-a-teleost-fish
#17
Hideaki Toda, Yasutaka Saito, Takuhito Koike, Fumio Takizawa, Kyosuke Araki, Takeshi Yabu, Tomonori Somamoto, Hiroaki Suetake, Yuzuru Suzuki, Mitsuru Ototake, Tadaaki Moritomo, Teruyuki Nakanishi
The presence of helper and cytotoxic T cells in fish has been suggested, although T cell subsets have yet to be identified at the cellular level. In order to investigate the functions of CD4 and CD8α positive T cells we attempted to produce and characterize monoclonal antibodies (mAbs) against teleost CD4 and CD8α. Here we report the successful production of mAbs against CD4 and CD8α in clonal ginbuna crucian carp Carassius auratus langsdorfii and the function of CD4 positive T cells. In this study we demonstrate the presence of teleost CD4- and CD8α-positive T cell subsets with morphology, tissue distribution and gene expression similar to those of mammalian CD4- and CD8-positive T lymphocytes...
June 2011: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/20518128/dynamic-nuclear-polarization-experiments-at-14-1-t-for-solid-state-nmr
#18
Yoh Matsuki, Hiroki Takahashi, Keisuke Ueda, Toshitaka Idehara, Isamu Ogawa, Mitsuru Toda, Hideo Akutsu, Toshimichi Fujiwara
Instrumentation for high-field dynamic nuclear polarization (DNP) at 14.1 T was developed to enhance the nuclear polarization for NMR of solids. The gyrotron generated 394.5 GHz submillimeter (sub-mm) wave with a power of 40 W in the second harmonic TE(0,6) mode. The sub-mm wave with a power of 0.5-3 W was transmitted to the sample in a low-temperature DNP-NMR probe with a smooth-wall circular waveguide system. The (1)H polarization enhancement factor of up to about 10 was observed for a (13)C-labeled compound with nitroxyl biradical TOTAPOL...
June 14, 2010: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/19848248/usefulness-of-curry-odorant-of-odor-stick-identification-test-for-japanese-in-olfactory-impairment-screening
#19
Hideaki Shiga, Hideki Toda, Tatsu Kobayakawa, Sachiko Saito, Kyoko Hirota, Toshiaki Tsukatani, Mitsuru Furukawa, Takaki Miwa
CONCLUSION: The curry odorant of the odor stick identification test for Japanese (OSIT-J) is useful in screening for olfactory impairment in Japanese subjects. OBJECTIVE: The present study was designed to determine the most useful odorant of the OSIT-J in screening for olfactory impairment in Japanese subjects. SUBJECTS AND METHODS: We studied olfactory impairment screening with the OSIT-J in 83 participants (49 male, 34 female; average age 50 years) in an executive check-up at NTT West Kanazawa Hospital...
June 2009: Acta Oto-laryngologica. Supplementum
https://www.readbyqxmd.com/read/19073209/alloantigen-specific-killing-is-mediated-by-cd8-positive-t-cells-in-fish
#20
Hideaki Toda, Yasuhiro Shibasaki, Takuhito Koike, Maki Ohtani, Fumio Takizawa, Mitsuru Ototake, Tadaaki Moritomo, Teruyuki Nakanishi
CD8-positive (CD8(+)) cytotoxic T lymphocytes (CTL) have antigen-specific cytotoxic activity. In fish, however, CTL expressing CD8 on their cell surface have not been identified. In order to characterize the cells involved in specific cell-mediated cytotoxicity in teleosts, we separated and sorted ginbuna kidney leucocytes into CD8alpha(+), CD4(+) and surface IgM (sIgM)(+) cells by magnetic activated cell sorting using monoclonal antibodies and examined their cytotoxic activities. Effector donor ginbuna (OB1 clone) were sensitized by allografting scales from S3N clone fish followed by injection of an allogeneic cell line (CFS) derived from S3N fish...
April 2009: Developmental and Comparative Immunology
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