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https://www.readbyqxmd.com/read/28090332/long-term-effect-of-intensive-lifestyle-intervention-on-cardiovascular-risk-factors-in-patients-with-diabetes-in-real-world-clinical-practice-a-5-year-longitudinal-study
#1
Osama Hamdy, Adham Mottalib, Amr Morsi, Nuha El-Sayed, Ann Goebel-Fabbri, Gillian Arathuzik, Jacqueline Shahar, Amanda Kirpitch, John Zrebiec
OBJECTIVE: We evaluated long-term impact of sustained weight loss versus weight regain on cardiovascular risk factors in real-world clinical practice. METHODS: We evaluated 129 obese patients with diabetes enrolled in Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week clinical model of intensive lifestyle intervention. After 1 year, we divided participants into group A, who maintained <7% weight loss (47.3%) and group B (52.7%), who maintained ≥7% weight loss...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28089627/the-relationship-between-tamoxifen-associated-nonalcoholic-fatty-liver-disease-and-the-prognosis-of-patients-with-early-stage-breast-cancer
#2
Meiying Yan, Jingxuan Wang, Qijia Xuan, Tieying Dong, Juan He, Qingyuan Zhang
PURPOSE: To investigate the relationship between tamoxifen-associated nonalcoholic fatty liver disease (NAFLD) and survival outcomes in patients with breast cancer. METHODS: Patients with early-stage invasive breast cancer after curative resection from January 2009 to June 2011 were selected. A total of 646 patients who were treated with tamoxifen were included. Patients diagnosed with NAFLD on ultrasonography were classified into the NAFLD and non-NAFLD groups...
December 24, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28089571/normo-and-hyperandrogenic-women-with-polycystic-ovary-syndrome-exhibit-an-adverse-metabolic-profile-through-life
#3
Pekka Pinola, Katri Puukka, Terhi T Piltonen, Johanna Puurunen, Eszter Vanky, Inger Sundström-Poromaa, Elisabet Stener-Victorin, Angelica Lindén Hirschberg, Pernille Ravn, Marianne Skovsager Andersen, Dorte Glintborg, Jan Roar Mellembakken, Aimo Ruokonen, Juha S Tapanainen, Laure C Morin-Papunen
OBJECTIVE: To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. DESIGN: Case-control study. SETTING: Not applicable. PATIENT(S): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years)...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28088267/a-meta-analysis-of-three-identified-single-nucleotide-polymorphisms-at-1p13-3-and-1q41-and-their-associations-with-lipid-levels-and-coronary-artery-disease
#4
Qian-Chao He, Yu-Ying Hu, Qing-Ping Zhang, Lu-Lu Tan, Yong-Hui Liu, Tai Liu, Yue-Qiang Hu, Qing Li, Ni Liang
The aim of this meta-analysis was to detect whether three identified single nucleotide polymorphisms (SNPs) (rs646776, rs599839, and rs17465637) at 1p13.3 and 1q41 are associated with lipid levels and the risk of coronary artery disease (CAD). Databases of MEDLINE, EMBASE, the Cochrane Library, and BIOSIS were systematically searched. The pooled effects were expressed as odds ratio or standardized mean difference or mean difference with 95% confidence intervals. A total of 14 studies with 57,916 patients were included in the meta-analysis...
January 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28087911/-aortic-stiffness-and-its-influencing-factors-in-patients-with-chronic-kidney-disease
#5
Binxian Ye, Li Zhao, Wei Shen, Yan Ren, Bo Lin, Maosheng Chen, Junda Tang, Xinxin Jiang, Yiwen Li, Qiang He
Objective: To investigate the changes of aortic stiffness and its influencing factors in patients with chronic kidney diseases (CKD). Methods: Eightyfour patients with CKD from Department of Nephrology, Zhejiang Provincial People's Hospital were divided into the dialysis group (CKD stage 5, n=48) and non-dialysis group (CKD stage 3-5, n=36). Clinical data, biochemical parameters and echocardiography findings were collected. SphygmoCor pulse wave analysis system was used to obtain pulse wave analysis (PWA) parameters including central aortic systolic blood pressure (CSP), central pulse pressure (CPP), augmented pressure (AP), augmentation index (AIX), and heart rate 75-adjusted augmentation index (HR75AIX)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28086813/information-exchange-networks-of-health-care-providers-and-evidence-based-cardiovascular-risk-management-an-observational-study
#6
Naomi Heijmans, Jan van Lieshout, Michel Wensing
BACKGROUND: Although a wide range of preventive and clinical interventions has targeted cardiovascular risk management (CVRM), outcomes remain suboptimal. Therefore, the question is what additional determinants of CVRM and outcomes can be identified and addressed to optimize CVRM. In this study, we aimed to identify new perspectives for improving healthcare delivery and explored associations between information exchange networks of health care providers and evidence-based CVRM. METHODS: This observational study was performed parallel to a randomized clinical trial which aimed to improve professional performance of practice nurses in the Netherlands...
January 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28081164/economic-evaluation-of-pcsk9-inhibitors-in-reducing-cardiovascular-risk-from-health-system-and-private-payer-perspectives
#7
Alejandro Arrieta, Timothy F Page, Emir Veledar, Khurram Nasir
The introduction of Proprotein covertase subtilisin/kexin type 9 (PCSK9) inhibitors has been heralded as a major advancement in reducing low-density lipoprotein cholesterol levels by nearly 50%. However, concerns have been raised on the added value to the health care system in terms of their costs and benefits. We assess the cost-effectiveness of PCSK9 inhibitors based on a decision-analytic model with existing clinical evidence. The model compares a lipid-lowering therapy based on statin plus PCSK9 inhibitor treatment with statin treatment only (standard therapy)...
2017: PloS One
https://www.readbyqxmd.com/read/28077384/predictors-of-nonuse-of-a-high-potency-statin-after-an-acute-coronary-syndrome-insights-from-the-stabilization-of-plaques-using-darapladib-thrombolysis-in-myocardial-infarction-52-solid-timi-52-trial
#8
Alon Eisen, Christopher P Cannon, Eugene Braunwald, Dylan L Steen, Jing Zhou, Erica L Goodrich, KyungAh Im, Anthony J Dalby, Jindrich Spinar, Shruti Daga, Mary Ann Lukas, Michelle L O'Donoghue
BACKGROUND: High-potency statins reduce cardiovascular events after acute coronary syndromes but remain underused in clinical practice. We examined predictors of nonuse of high-potency statins after acute coronary syndromes. METHODS AND RESULTS: The Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial enrolled patients after an acute coronary syndrome in 36 countries between 2009 and 2011. Statin use was strongly encouraged throughout the trial, and statin potency was at the discretion of the treating physician...
January 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28077112/prevalence-and-factors-associated-with-hypertension-in-burkina-faso-a-countrywide-cross-sectional-study
#9
Joseph Kouesyandé Soubeiga, Tieba Millogo, Brice W Bicaba, Boukare Doulougou, Séni Kouanda
BACKGROUND: High blood pressure (HBP) is an increasing public health issue for developing countries. HBP is an important contributing factor to many non-communicable diseases that were until very recently thought to be rare in developing countries. There is not enough evidence on its burden and risk factors in Africa. We report in this study on the prevalence and factors associated with HBP in the adult and active population of Burkina Faso from a nationally representative sample. METHODS: We conducted a secondary analysis of data from the World Health Organization (WHO) Stepwise approach to Surveillance(STEPS) survey on the prevalence of major risk factors for non-communicable diseases in Burkina Faso...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28077069/a-pilot-study-of-brisk-walking-in-sedentary-combination-antiretroviral-treatement-cart-treated-patients-benefit-on-soluble-and-cell-inflammatory-markers
#10
Matteo Bonato, Laura Galli, Laura Passeri, Valeria Longo, Gaspare Pavei, Simona Bossolasco, Cecilia Bertocchi, Massimo Cernuschi, Giuseppe Balconi, Giampiero Merati, Adriano Lazzarin, Antonio La Torre, Paola Cinque
BACKGROUND: Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. The objective was to assess the effects of moderate intensity exercise on metabolic and inflammatory markers in HIV-infected treated persons. METHODS: This was a pilot study enrolling cART-treated, sedentary persons with metabolic complications in a 12-week protocol, consisting of three sessions per week of 60 min brisk walking with (strength-walk group) or without (walk group) 30 min circuit-training...
January 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28076633/statins-for-aortic-valve-stenosis
#11
Luciana Thiago, Selma Rumiko Tsuji, Jonathan Nyong, Maria Eduarda Dos Santos Puga, Aécio Flávio Teixeira de Góis, Cristiane Rufino Macedo, Orsine Valente, Álvaro Nagib Atallah
BACKGROUND: Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease. Some studies have evaluated statins for aortic valve stenosis. OBJECTIVES: To evaluate the effectiveness and safety of statins in aortic valve stenosis. METHODS: Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, LILACS - IBECS, Web of Science and CINAHL Plus...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#12
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28071756/association-between-reductions-in-low-density-lipoprotein-cholesterol-with-statin-therapy-and-the-risk-of-new-onset-diabetes-a-meta-analysis
#13
Shaohua Wang, Rongrong Cai, Yang Yuan, Zac Varghese, John Moorhead, Xiong Z Ruan
A recent meta-analysis demonstrated that statin therapy was associated with a risk of diabetes. The present study investigated whether the relative reduction in low-density lipoprotein cholesterol (LDL-c) was a good indicator of the risk of new-onset diabetes. We searched the PubMed, Embase, Cochrane Central Register, Lilacs, Food and Drug Administration, and European Medicines Agency databases for randomized controlled trials of statins. Fourteen trials were included in the study. Eight trials with target LDL-c levels ≤100 mg/dL (2...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071023/effect-of-food-processing-on-the-physicochemical-properties-of-dietary-fibre
#14
Vasfiye Hazal Ozyurt, Semih Ötles
Products derived from the manufacturing or processing of plant based foods: cereals, fruits, vegetables, as well as algae, are sources of abundant dietary fibre. Diets high in dietary fibre have been associated with the reduced risk of cardiovascular disease, diabetes, hypertension, obesity, and gastrointestinal disorders. These fibre-rich products and byproducts can also fortify foods, increase their dietary fibre content and result in healthy products, low in calories, cholesterol and fat. Traditionally, consumers have chosen foods such as whole grains, fruits and vegetables as sources of dietary fibre...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28070463/impact-of-birth-weight-and-postnatal-diet-on-the-gut-microbiota-of-young-adult-guinea-pigs
#15
Kait Al, Ousseynou Sarr, Kristyn Dunlop, Gregory B Gloor, Gregor Reid, Jeremy Burton, Timothy R H Regnault
BACKGROUND: The gastrointestinal tract (GIT) microbiota is essential to metabolic health, and the prevalence of the Western diet (WD) high in fat and sugar is increasing, with evidence highlighting a negative interaction between the GIT and WD, resulting in liver dysfunction. Additionally, an adverse in utero environment such as placental insufficiency resulting in low birth weight (LBW) offspring, contributes to an increased risk of metabolic diseases such as fatty liver infiltration and liver dysfunction in later life...
2017: PeerJ
https://www.readbyqxmd.com/read/28068529/impact-of-high-dose-statins-on-vitamin-d-levels-and-platelet-function-in-patients-with-coronary-artery-disease
#16
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Alon Schaffer, Lucia Barbieri, Veronica Daffara, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Statins represent a pivotal treatment in coronary artery disease, offering a reduction in cardiovascular risk even beyond their lipid-lowering action. However, the mechanism of these "pleiotropic" benefits of statins is poorly understood. Vitamin D has been suggested as a potential mediator of the anti-inflammatory, anti-thrombotic and vascular protecting effects of statins. Aim of present study was to assess the impact of a high-intensity statin therapy on vitamin D levels and platelet function in patients with coronary artery disease...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28067456/type-2-diabetes-mellitus-associated-with-the-interaction-of-lrp5-polymorphism-and-overweight-and-obesity-in-rural-chinese-adults
#17
Zhang Lu, Wang Jinjin, Zhang Ming, Wang Guo'an, Shen Yanxia, Wu Dongting, Wang Chongjian, Li Linlin, Ren Yongcheng, Wang Bingyuan, Zhang Hongyan, Yang Xiangyu, Zhao Yang, Han Chengyi, Zhou Junmei, Pang Chao, Yin Lei, Zhao Jingzhi, Luo Xinping, Hu Dongsheng
BACKGROUND: Low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in glucose and cholesterol metabolism, so a cohort study was used to evaluate the association of LRP5 variants and incidence of type 2 diabetes mellitus (T2DM) in a rural adult Chinese population. METHODS: A total of 7751 subjects ≥18 years old and without T2DM underwent genotyping at baseline; 6326 subjects (81.62%) were followed-up, with 5511 eligible for this analysis...
January 9, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28065951/the-association-of-age-with-glycaemic-and-cholesterol-control-in-patients-with-type-2-diabetes-mellitus
#18
Raheela Yasmin, Asifa Majeed, Amir Rashid, Suhail Razak
OBJECTIVE: To find the risk of dyslipidaemia in diabetic patients of different age groups. METHODS: This cross-sectional study was conducted at Holy Family Hospital, Rawalpindi, and Pakistan Ordnance Factories Hospital, Wah Cantonment, Pakistan, from February to July 2014, and comprised type 2 diabetic patients. Patients' body mass index was calculated and biochemical tests were performed for high-density lipoprotein, total cholesterol, low-density lipoprotein, triglyceride and glucose...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28065900/exploring-the-predictive-power-of-polygenic-scores-derived-from-genome-wide-association-studies-a-study-of-10-complex-traits
#19
Hon-Cheong So, Pak C Sham
MOTIVATION: It is hoped that advances in our knowledge in disease genomics will contribute to personalized medicine such as individualized preventive strategies or early diagnoses of diseases. With the growth of genome-wide association studies (GWAS) in the past decade, how far have we reached this goal? In this study we explored the predictive ability of polygenic risk scores (PRSs) derived from GWAS for a range of complex disease and traits. RESULTS: We first proposed a new approach to evaluate predictive performances of PRS at arbitrary P-value thresholds...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28065479/interaction-between-a-variant-of-cdkn2a-b-gene-with-lifestyle-factors-in-determining-dyslipidemia-and-estimated-cardiovascular-risk-a-step-toward-personalized-nutrition
#20
Mehrane Mehramiz, Faeze Ghasemi, Habibollah Esmaily, Maryam Tayefi, Seyed Mahdi Hassanian, Mahsa Sadeghzade, Fatemeh Sadabadi, Mohsen Moohebati, Mahmoud Reza Azarpazhooh, Seyed Mohammad Reza Parizadeh, Alireza Heidari-Bakavoli, Mohammad Safarian, Mohsen Nematy, Mahmoud Ebrahimi, Mikhail Ryzhikov, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
BACKGROUND & AIMS: Several genome-wide-association-studies have identified genetic variants in a region on chromosome 9p21 that are associated with an increased risk of Cardiovascular disease (CVD) and diabetes. Here we have explored the interaction of a genetic variant of the CDKN2A/B-rs10811661 gene locus with cardiovascular risk factors and environmental-exposures (e.g., diet and physical activity) in 1165 individuals recruited from the Mashhad-Stroke and Heart-Atherosclerotic-Disorders cohort...
December 28, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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