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ARI AND berberine

Hong-Zhou Yang, Ming-Mei Zhou, Ai-Hua Zhao, Shu-Ning Xing, Zi-Quan Fan, Wei Jia
OBJECTIVE: To observe the activities of baicalin, berberine and Astragalus polysaccharides and their combinative effects on aldose reductase (AR) by a screening model of aldose reductase inhibitor (ARI) in vitro. METHODS: The inhibition of AR by baicalin, berberine and Astragalus polysaccharides and positive drug (Epalrestat) in different concentrations were evaluated, and their combinative effects were studied according to orthogonal t design. RESULTS: Baicalin and berberine had remarkable inhibitory effects on AR, the inhibitory rates were (88...
August 2009: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
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