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https://www.readbyqxmd.com/read/29334350/bespoke-automation-of-medical-workforce-rostering-using-google-s-free-cloud-applications
#1
Peter Benjamin Michael Thomas
BACKGROUND: Providing safe and consistent care requires optimal deployment of medical staff. Ensuring this happens is a significant administrative burden due to complex working patterns. OBJECTIVE: To describe a pilot feasibility study of the automation of medical duty rostering in a busy tertiary Ophthalmology department. METHODS: A cloud based web application was created using Google's free cloud services. Users access the system via a website which hosts live rosters, and use electronic forms to submit requests which are automatically handled by Google App Scripts...
December 11, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29334178/factors-associated-with-perceived-accuracy-of-the-undetectable%C3%A2-%C3%A2-untransmittable-slogan-among-men-who-have-sex-with-men-implications-for-messaging-scale-up-and-implementation
#2
H Jonathon Rendina, Jeffrey T Parsons
INTRODUCTION: Recent research has shown high efficacy of HIV treatment for reducing the risk of HIV transmission to sexual partners. As the efficacy of treatment as prevention (TasP) has proliferated, a new messaging campaign, Undetectable = Untransmittable, has been gaining popularity. The purpose of this paper was to assess factors associated with the perceived accuracy of this TasP messaging strategy among a large and diverse sample of gay, bisexual, and other men who have sex with men (GBMSM) in order to inform subsequent efforts at large-scale and implementation of the HIV prevention message...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29332037/increased-vulnerability-of-the-hippocampus-in-transgenic-mice-overexpressing-app-and-triple-repeat-tau
#3
Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissman
 Alzheimer's disease (AD) is the most common tauopathy, characterized by progressive accumulation of amyloid-β (Aβ) and hyperphosphorylated tau. While pathology associated with the 4-repeat (4R) tau isoform is more abundant in corticobasal degeneration and progressive supranuclear palsy, both 3R and 4R tau isoforms accumulate in AD. Many studies have investigated interactions between Aβ and 4R tau in double transgenic mice, but few, if any, have examined the effects of Aβ with 3R tau. To examine this relationship, we crossed our APP751 mutant line with our recently characterized 3R tau mutant model to create a bigenic line (hAPP-3RTau) to model AD neuropathology...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331693/disease-management-apps-and-technical-assistance-systems-for-bipolar-disorder-investigating-the-patients%C3%A2-point-of-view
#4
Henning Daus, Natalia Kislicyn, Stephan Heuer, Matthias Backenstrass
BACKGROUND: Smartphone-based disease management has become increasingly interesting for research in the field of bipolar disorders. This article investigates the attitudes of persons affected by this disorder towards the appropriation of mobile apps or assistance systems for the management of their disease. METHODS: We conducted two separate studies. Study 1 was an online survey with 88 participants. In study 2 we consulted 15 participants during a semi-structured interview...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29330081/optimization-of-a-technology-supported-physical-activity-intervention-for-breast-cancer-survivors-fit2thrive-study-protocol
#5
Siobhan M Phillips, Linda M Collins, Frank J Penedo, Kerry S Courneya, Whitney Welch, Alison Cottrell, Gillian R Lloyd, Kara Gavin, David Cella, Ronald T Ackermann, Juned Siddique, Bonnie Spring
Fit2Thrive is a theory-guided physical activity promotion trial using the Multiphase Optimization Strategy (MOST) to test efficacy for improving physical activity of five technology-supported physical activity promotion intervention components among breast cancer survivors. This trial will recruit 256 inactive breast cancer survivors nationwide. All participants will receive the core intervention which includes a Fitbit and standard self-monitoring Fit2Thrive smartphone application which will be downloaded to their personal phone...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29329530/design-and-evaluation-of-a-mobile-application-to-assist-the-self-monitoring-of-the-chronic-kidney-disease-in-developing-countries
#6
Alvaro Sobrinho, Leandro Dias da Silva, Angelo Perkusich, Maria Eliete Pinheiro, Paulo Cunha
BACKGROUND: The chronic kidney disease (CKD) is a worldwide critical problem, especially in developing countries. CKD patients usually begin their treatment in advanced stages, which requires dialysis and kidney transplantation, and consequently, affects mortality rates. This issue is faced by a mobile health (mHealth) application (app) that aims to assist the early diagnosis and self-monitoring of the disease progression. METHODS: A user-centered design (UCD) approach involving health professionals (nurse and nephrologists) and target users guided the development process of the app between 2012 and 2016...
January 12, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29328367/tumorigenic-proteins-upregulated-in-the-mycn-amplified-imr-32-human-neuroblastoma-cells-promote-proliferation-and-migration
#7
Hayat Zaatiti, Jad Abdallah, Zeina Nasr, George Khazen, Anthony Sandler, Tamara J Abou-Antoun
Childhood neuroblastoma is one of the most common types of extra-cranial cancer affecting children with a clinical spectrum ranging from spontaneous regression to malignant and fatal progression. In order to improve the clinical outcomes of children with high-risk neuroblastoma, it is crucial to understand the tumorigenic mechanisms that govern its malignant behaviors. MYCN proto-oncogene, bHLH transcription factor (MYCN) amplification has been implicated in the malignant, treatment-evasive nature of aggressive, high-risk neuroblastoma...
January 4, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29326184/assessing-the-effectiveness-of-a-patient-centred-computer-based-clinic-intervention-health-e-you-salud-itu-to-reduce-health-disparities-in-unintended-pregnancies-among-hispanic-adolescents-study-protocol-for-a-cluster-randomised-control-trial
#8
Kathleen P Tebb, Felicia Rodriguez, Lance M Pollack, Sang Leng Trieu, Loris Hwang, Maryjane Puffer, Sally Adams, Elizabeth M Ozer, Claire D Brindis
INTRODUCTION: Teen pregnancy rates in the USA remain higher than any other industrialised nation, and pregnancies among Hispanic adolescents are disproportionately high. Computer-based interventions represent a promising approach to address sexual health and contraceptive use disparities. Preliminary findings have demonstrated that the Health-E You/Salud iTu, computer application (app) is feasible to implement, acceptable to Latina adolescents and improves sexual health knowledge and interest in selecting an effective contraceptive method when used in conjunction with a healthcare visit...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29326098/cognitive-and-behavioral-skills-exercises-completed-by-patients-with-major-depression-during-smartphone-cognitive-behavioral-therapy-secondary-analysis-of-a-randomized-controlled-trial
#9
Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa
BACKGROUND: A strong and growing body of evidence has demonstrated the effectiveness of cognitive behavioral therapy (CBT), either face-to-face, in person, or as self-help via the Internet, for depression. However, CBT is a complex intervention consisting of several putatively effective components, and how each component may or may not contribute to the overall effectiveness of CBT is poorly understood. OBJECTIVE: The aim of this study was to investigate how the users of smartphone CBT use and benefit from various components of the program...
January 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29325505/the-relationship-between-cholesterol-level-and-alzheimer-s-disease-associated-app-proteolysis-a%C3%AE-metabolism
#10
Chaoqun Wang, Yikai Shou, Jie Pan, Yue Du, Cuiqing Liu, Huanhuan Wang
Globally, Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population, the hallmark of which is amyloid β (Aβ) peptide. Energy metabolism and AD pathogenesis are believed to influence one another. Different cholesterol levels are thought to influence various steps in neurotoxic Aβ generation, including amyloid precursor protein (APP) proteolysis and the corresponding activities of α-, β-, and γ-secretases. In addition, cholesterol has been proved to mediate Aβ metabolism, such as its fibrillation, transportation, degradation, and clearance processes...
January 11, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29324783/sirt3-activator-honokiol-attenuates-%C3%AE-amyloid-by-modulating-amyloidogenic-pathway
#11
Sindhu Ramesh, Manoj Govindarajulu, Tyler Lynd, Gwyneth Briggs, Danielle Adamek, Ellery Jones, Jake Heiner, Mohammed Majrashi, Timothy Moore, Rajesh Amin, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran
Honokiol (poly-phenolic lignan from Magnolia grandiflora) is a Sirtuin-3 (SIRT3) activator which exhibit antioxidant activity and augment mitochondrial functions in several experimental models. Modern evidence suggests the critical role of SIRT3 in the progression of several metabolic and neurodegenerative diseases. Amyloid beta (Aβ), the precursor to extracellular senile plaques, accumulates in the brains of patients with Alzheimer's disease (AD) and is related to the development of cognitive impairment and neuronal cell death...
2018: PloS One
https://www.readbyqxmd.com/read/29323524/work-disability-in-soldiers-with-posttraumatic-stress-disorder-posttraumatic-embitterment-disorder-and-not-event-related-common-mental-disorders
#12
Beate Muschalla, Heinrich Rau, Gerd Dieter Willmund, Christine Knaevelsrud
OBJECTIVE: Posttraumatic mental disorders may occur with different affect qualities. Best known is posttraumatic stress disorder (PTSD), a conditioned anxiety reaction with intrusions. Another event-related mental disorder is posttraumatic embitterment (PTED), characterized by affect of embitterment and thoughts of revenge, occurring after an event deeply hurting basic beliefs. Knowing about associated disability is important for treatment and sociomedical decisions. This is the first study to explore work-disability in patients with PTSD, PTED, and not-event-related common mental disorder (CMD)...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29321124/hearing-tests-based-on-biologically-calibrated-mobile-devices-comparison-with-pure-tone-audiometry
#13
Marcin Masalski, Tomasz Grysiński, Tomasz Kręcicki
BACKGROUND: Hearing screening tests based on pure-tone audiometry may be conducted on mobile devices, provided that the devices are specially calibrated for the purpose. Calibration consists of determining the reference sound level and can be performed in relation to the hearing threshold of normal-hearing persons. In the case of devices provided by the manufacturer, together with bundled headphones, the reference sound level can be calculated once for all devices of the same model. OBJECTIVE: This study aimed to compare the hearing threshold measured by a mobile device that was calibrated using a model-specific, biologically determined reference sound level with the hearing threshold obtained in pure-tone audiometry...
January 10, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29321122/technology-assisted-behavioral-intervention-to-extend-sleep-duration-development-and-design-of-the-sleep-bunny-mobile-app
#14
Kelly Glazer Baron, Jennifer Duffecy, Kathryn Reid, Mark Begale, Lauren Caccamo
BACKGROUND: Despite the high prevalence of short sleep duration (29.2% of adults sleep <6 hours on weekdays), there are no existing theory-based behavioral interventions to extend sleep duration. The popularity of wearable sleep trackers provides an opportunity to engage users in interventions. OBJECTIVE: The objective of this study was to outline the theoretical foundation and iterative process of designing the "Sleep Bunny," a technology-assisted sleep extension intervention including a mobile phone app, wearable sleep tracker, and brief telephone coaching...
January 10, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29320530/the-amyloid-precursor-protein-derivative-app96-110-is-efficacious-following-intravenous-administration-after-traumatic-brain-injury
#15
Stephanie L Plummer, Frances Corrigan, Emma Thornton, Joshua A Woenig, Robert Vink, Roberto Cappai, Corinna Van Den Heuvel
Following traumatic brain injury (TBI) neurological damage is ongoing through a complex cascade of primary and secondary injury events in the ensuing minutes, days and weeks. The delayed nature of secondary injury provides a valuable window of opportunity to limit the consequences with a timely treatment. Recently, the amyloid precursor protein (APP) and its derivative APP96-110 have shown encouraging neuroprotective activity following TBI following an intracerebroventricular administration. Nevertheless, its broader clinical utility would be enhanced by an intravenous (IV) administration...
2018: PloS One
https://www.readbyqxmd.com/read/29317385/development-and-evaluation-of-a-mobile-personalized-blood-glucose-prediction-system-for-patients-with-gestational-diabetes-mellitus
#16
Evgenii Pustozerov, Polina Popova, Aleksandra Tkachuk, Yana Bolotko, Zafar Yuldashev, Elena Grineva
BACKGROUND: Personalized blood glucose (BG) prediction for diabetes patients is an important goal that is pursued by many researchers worldwide. Despite many proposals, only a few projects are dedicated to the development of complete recommender system infrastructures that incorporate BG prediction algorithms for diabetes patients. The development and implementation of such a system aided by mobile technology is of particular interest to patients with gestational diabetes mellitus (GDM), especially considering the significant importance of quickly achieving adequate BG control for these patients in a short period (ie, during pregnancy) and a typically higher acceptance rate for mobile health (mHealth) solutions for short- to midterm usage...
January 9, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29317379/effect-of-a-gender-tailored-ehealth-weight-loss-program-on-the-depressive-symptoms-of-overweight-and-obese-men-pre-post-study
#17
Myles D Young, Philip J Morgan
BACKGROUND: Obesity and depression are of two of the largest contributors to the global burden of disease in men. Although lifestyle behavior change programs can improve participants' weight and depressive symptoms, the evidence is limited by a lack of male participants and a reliance on face-to-face treatment approaches, which are not accessible or appealing for many men. OBJECTIVE: This study examined the effect of a gender-tailored electronic health (eHealth) program on the depressive symptoms of a community sample of overweight and obese men with or without depression...
January 9, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29315574/palmitate-induced-c-ebp-homologous-protein-activation-leads-to-nf-%C3%AE%C2%BAb-mediated-increase-in-bace1-activity-and-amyloid-beta-genesis
#18
Gurdeep Marwarha, Jared Schommer, Jonah Lund, Trevor Schommer, Othman Ghribi
The etiology of Alzheimer's disease (AD) is egregiously comprehended, but epidemiological studies have posited that diets rich in the saturated fatty acid palmitic acid (palmitate) are a significant risk factor. The production and accumulation of Amyloid-beta peptide (Aβ) is considered the core pathological molecular event in the pathogenesis of AD. The rate limiting step in Aβ genesis from Amyloid-β precursor protein (AβPP) is catalyzed by the enzyme β-site APP cleaving enzyme 1 (BACE1), the expression and enzymatic activity of which is significantly upregulated in the AD brain...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29302204/metagenome-analysis-of-bodily-microbiota-in-a-mouse-model-of-alzheimer-disease-using-bacteria-derived-membrane-vesicles-in-blood
#19
Jin-Young Park, Juli Choi, Yunjin Lee, Jung-Eun Lee, Eun-Hwa Lee, Hye-Jin Kwon, Jinho Yang, Bo-Ri Jeong, Yoon-Keun Kim, Pyung-Lim Han
Emerging evidence has suggested that the gut microbiota contribute to brain dysfunction, including pathological symptoms of Alzheimer disease (AD). Microbiota secrete membrane vesicles, also called extracellular vesicles (EVs), which contain bacterial genomic DNA fragments and other molecules and are distributed throughout the host body, including blood. In the present study, we investigated whether bacteria-derived EVs in blood are useful for metagenome analysis in an AD mouse model. Sequence readings of variable regions of 16S rRNA genes prepared from blood EVs in Tg-APP/PS1 mice allowed us to identify over 3,200 operational taxonomic units corresponding to gut microbiota reported in previous studies...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29301737/privacy-policies-for-apps-targeted-toward-youth-descriptive-analysis-of-readability
#20
Gitanjali Das, Cynthia Cheung, Camille Nebeker, Matthew Bietz, Cinnamon Bloss
BACKGROUND: Due to the growing availability of consumer information, the protection of personal data is of increasing concern. OBJECTIVE: We assessed readability metrics of privacy policies for apps that are either available to or targeted toward youth to inform strategies to educate and protect youth from unintentional sharing of personal data. METHODS: We reviewed the 1200 highest ranked apps from the Apple and Google Play Stores and systematically selected apps geared toward youth...
January 4, 2018: JMIR MHealth and UHealth
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