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https://www.readbyqxmd.com/read/29669818/changes-in-glomerular-filtration-rate-and-impact-on-long-term-survival-among-adults-after-hematopoietic-cell-transplantation-a-prospective-cohort-study
#1
Sangeeta Hingorani, Emily Pao, Phil Stevenson, Gary Schoch, Benjamin L Laskin, Ted Gooley, George B McDonald
BACKGROUND AND OBJECTIVES: Kidney injury is a significant complication for patients undergoing hematopoietic cell transplantation (HCT), but few studies have prospectively examined changes in GFR in long-term survivors of HCT. We described the association between changes in GFR and all-cause mortality in patients up to 10 years after HCT. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective, observational cohort study of adult patients undergoing HCT at the Fred Hutchinson Cancer Center in Seattle, Washington from 2003 to 2015...
April 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29668527/opioid-and-benzodiazepine-use-before-injury-among-workers-in-washington-state-2012-2015
#2
Esi W Nkyekyer, Deborah Fulton-Kehoe, June Spector, Gary Franklin
OBJECTIVE: To characterize pre-injury prescription opioid and benzodiazepine use and its relationship with post-injury use and missed work among workers. METHODS: 313,543 Washington State Department of Labor and Industries workers' compensation injury claims from 2012-2015 were linked with State Prescription Monitoring Program data. Pre-injury prevalence of opioid and benzodiazepine use were compared between compensable and non-compensable claims, and between workers with and without post-injury prescriptions, using the Pearson Chi-Square test...
April 17, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29665612/differences-in-segmental-speeds-as-a-function-of-maturation-in-youth-baseball-pitchers
#3
Jessica K Washington, Gabrielle G Gilmer, Jeff W Barfield, Sarah S Gascon, Michael G Saper, Jeffrey R Dugas, James R Andrews, Gretchen D Oliver
The purpose of this study was to determine how stride length, segmental sequencing of the pelvis, trunk, humerus, and forearm velocities and accelerations, and the timing of these values change as youth mature. Thirteen youth baseball pitchers participated at three consecutive time points: visit 1 (10.7±1.3 years; 151.8±10.7 cm; 45.0±9.65 kg), visit 2 (11.5±1.6 years; 155.5±11.1 cm; 50.4±10.0 kg), and visit 3 (12.4±1.7 years; 161.5±11.7 cm; 56.4±10.8 kg). Participants executed three pitches for a strike to a catcher...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29662130/application-of-improved-approach-to-evaluate-a-community-intervention-to-reduce-exposure-of-young-children-living-in-farmworker-households-to-organophosphate-pesticides
#4
William C Griffith, Eric M Vigoren, Marissa N Smith, Tomomi Workman, Beti Thompson, Gloria D Coronado, Elaine M Faustman
The take-home pathway is a significant source of organophosphate pesticide exposure for young children (3-5 years old) living with an adult farmworker. This avoidable exposure pathway is an important target for intervention. We selected 24 agricultural communities in the Yakima Valley of Washington State and randomly assigned them to receive an educational intervention (n = 12) to reduce children's pesticide exposure or usual care (n = 12). We assessed exposure to pesticides in nearly 200 adults and children during the pre and post-intervention periods by measuring metabolites in urine...
April 17, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29659893/temporal-mitogenomics-of-the-galapagos-giant-tortoise-from-pinz%C3%A3-n-reveals-potential-biases-in-population-genetic-inference
#5
Evelyn L Jensen, Joshua M Miller, Danielle L Edwards, Ryan C Garrick, Washington Tapia, Adalgisa Caccone, Michael A Russello
Empirical population genetic studies generally rely on sampling subsets of the population(s) of interest and of the nuclear or organellar genome targeted, assuming each are representative of the whole. Violations of these assumptions may impact population-level parameter estimation and lead to spurious inferences. Here we used targeted capture to sequence the full mitochondrial genome from 123 individuals of the Galapagos giant tortoise endemic to Pinzón Island (Chelonoidis duncanensis) sampled at two time points pre- and post-bottleneck (circa 1906 and 2014) to explicitly assess differences in diversity estimates and demographic reconstructions based on subsets of the mitochondrial genome versus the full sequences, and to evaluate potential biases associated with diversity estimates and demographic reconstructions from post-bottlenecked samples alone...
April 6, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29619643/economic-impact-of-multisystemic-therapy-for-child-abuse-and-neglect
#6
Alex R Dopp, Cindy M Schaeffer, Cynthia Cupit Swenson, Jennifer S Powell
This study evaluated the economics of Multisystemic Therapy for Child Abuse and Neglect (MST-CAN) by applying the Washington State Institute for Public Policy (WSIPP) cost-benefit model to data from a randomized effectiveness trial with 86 families (Swenson et al. in JFP 24:497-507, 2010b). The net benefit of MST-CAN, versus enhanced outpatient treatment, was $26,655 per family at 16 months post-baseline. Stated differently, every dollar spent on MST-CAN recovered $3.31 in savings to participants, taxpayers, and society at large...
April 4, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29618365/apolipoprotein-e4-impairs-spontaneous-blood-brain-barrier-repair-following-traumatic-brain-injury
#7
Bevan S Main, Sonia Villapol, Stephanie S Sloley, David J Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S McCann, Patricia M Washington, Olga C Rodriguez, Mark P Burns
BACKGROUND: Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB) dysfunction is well documented in human TBI patients, yet the molecular mechanisms that underlie this neurovascular unit (NVU) pathology remains unclear. The apolipoprotein-E (apoE) protein has been implicated in controlling BBB integrity in an isoform dependent manner, via suppression of Cyclophilin A (CypA)-Matrix metallopeptidase-9 (MMP-9) signaling cascades, however the contribution of this pathway in TBI-induced BBB permeability is not fully investigated...
April 4, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29561173/evaluation-of-statin-eligibility-prescribing-practices-and-therapeutic-responses-using-atp-iii-acc-aha-and-nla-dyslipidemia-treatment-guidelines-in-a-large-urban-cohort-of-hiv-infected-outpatients
#8
Matthew E Levy, Alan E Greenberg, Manya Magnus, Naji Younes, Amanda Castel
Statin coverage has been examined among HIV-infected patients using Adult Treatment Panel III (ATP III) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines, although not with newer National Lipid Association (NLA) guidelines. We investigated statin eligibility, prescribing practices, and therapeutic responses using these three guidelines. Sociodemographic, clinical, and laboratory data were collected between 2011 and 2016 for HIV-infected outpatients enrolled in the DC Cohort, a multi-center, prospective, observational study in Washington, DC...
February 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29540763/fetal-extracellular-matrix-nerve-wraps-locally-improve-peripheral-nerve-remodeling-after-complete-transection-and-direct-repair-in-rat
#9
Tanchen Ren, Anne Faust, Yolandi van der Merwe, Bo Xiao, Scott Johnson, Apoorva Kandakatla, Vijay S Gorantla, Stephen F Badylak, Kia M Washington, Michael B Steketee
In peripheral nerve (PN) injuries requiring surgical repair, as in PN transection, cellular and ECM remodeling at PN epineurial repair sites is hypothesized to reduce PN functional outcomes by slowing, misdirecting, or preventing axons from regrowing appropriately across the repair site. Herein this study reports on deriving and analyzing fetal porcine urinary bladder extracellular matrix (fUB-ECM) by vacuum assisted decellularization, fabricating fUBM-ECM nerve wraps, and testing fUB-ECM nerve wrap biocompatibility and bioactivity in a trigeminal, infraorbital nerve (ION) branch transection and direct end-to-end repair model in rat...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540091/predictors-of-follow-up-visits-post-radical-prostatectomy
#10
Saira Khan, Veronica Hicks, Danielle Rancilio, Marvin Langston, Katina Richardson, Bettina F Drake
Long-term follow-up care among prostate cancer patients is important as biochemical recurrence can occur many years after diagnosis, with 20%-30% of men experiencing biochemical recurrence within 10 years of treatment. This study examined predictors of follow-up care among 1,158 radical prostatectomy patients, treated at the Washington University in St. Louis, within 6 months, 1 year, and 2 years post surgery. Predictors examined included age at surgery, race (Black vs. White), rural/urban status, education, marital status, and prostate cancer aggressiveness...
March 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29527296/management-of-eight-labor-and-delivery-patients-dependent-on-buprenorphine-subutex%C3%A2-a-retrospective-chart-review
#11
Solina Tith, Garinder Bining, Laurent Bollag
Background : Opioid use during pregnancy is a growing concern in the United States. Buprenorphine has been recommended by "The American College of Obstetrics and Gynecology" as an alternative to methadone to decrease risks associated with the use of illicit opioids during pregnancy. The partial μ-opioid agonists' unique pharmacology, including its long half time and high affinity to the μ-opioid receptor, complicates patient management in a highly kinetic, and often urgent field like obstetric anesthesia...
2018: F1000Research
https://www.readbyqxmd.com/read/29514910/depletion-of-the-insulator-protein-ctcf-results-in-hsv-1-reactivation-in-vivo
#12
Shannan D Washington, Samantha I Edenfield, Caroline Lieux, Zachary L Watson, Sean M Taasan, Adit Dhummakupt, David C Bloom, Donna M Neumann
Herpes Simplex Virus 1 (HSV-1) establishes a lifelong latent infection in host peripheral neurons including the neurons of the trigeminal ganglia (TG). HSV-1 can reactivate from neurons to cause recurrent infection. During latency, the insulator protein CTCF occupies DNA binding sites on the HSV-1 genome and these sites have been previously characterized as functional enhancer-blocking insulators. Previously, CTCF was found to be dissociated from wild type virus post-reactivation but not in mutants that do not reactivate, indicating that CTCF eviction may also be an important component of reactivation...
March 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29513914/aftermath-of-terror-a-nationwide-longitudinal-study-of-posttraumatic-stress-and-worry-across-the-decade-following-the-september-11-2001-terrorist-attacks
#13
Dana Rose Garfin, Michael J Poulin, Scott Blum, Roxane Cohen Silver
Research conducted in the early years after the September 11, 2001 (9/11) terrorist attacks in New York, Pennsylvania, and Washington, DC demonstrated adverse psychological outcomes among residents of the United States who were exposed to the attacks both directly and indirectly via the media. However, less is known about the impact of this collective trauma over time. Beginning at the end of December 2006, a longitudinal study of a nationally representative sample of U.S. residents (Cohort 2, N = 1,613) examined the long-term effects of 9/11, with annual assessments administered every year for 3 years...
February 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29485302/psychosocial-factors-that-shape-substance-abuse-and-related-mental-health-of-women-military-veterans-who-use-community-based-services
#14
Elizabeth A Evans, Dawn L Glover, Donna L Washington, Alison B Hamilton
BACKGROUND: Women Veterans who use the Veterans Health Administration (VA) have high rates of substance abuse and poorer health than non-Veteran women. Less is known about the psychosocial needs of women Veterans who seek care in non-VA settings. OBJECTIVES: We provide a grounded description of factors that impact substance abuse, mental health, and related quality of life of women Veterans who use non-VA community-based health and social services. METHODS: Utilizing a mixed methods design, we conducted semi-structured in-person interviews with 22 women Veterans in Los Angeles in 2013-2015...
February 27, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29484197/feasibility-and-assessment-of-outcome-measures-for-yoga-as-self-care-for-minorities-with-arthritis-a-pilot-study
#15
Kimberly R Middleton, Michael M Ward, Steffany Haaz Moonaz, Miriam Magaña López, Gladys Tataw-Ayuketah, Li Yang, Ana T Acevedo, Zavera Brandon, Gwenyth R Wallen
Background: While there is a growing interest in the therapeutic benefits of yoga, minority populations with arthritis tend to be under-represented in the research. Additionally, there is an absence of guidance in the literature regarding the use of multicultural teams and sociocultural health beliefs, when designing yoga studies for a racially diverse population with arthritis. This pilot study examined the feasibility of offering yoga as a self-care modality to an urban, bilingual, minority population with osteoarthritis (OA) or rheumatoid arthritis (RA), in the Washington, DC area...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29471924/employment-after-beginning-treatment-for-substance-use-disorders-the-impact-of-race-ethnicity-and-client-community-of-residence
#16
Andrea Acevedo, Jennifer Miles, Deborah W Garnick, Lee Panas, Grant Ritter, Kevin Campbell, Dolores Acevedo-Garcia
Employment is an important substance use treatment outcome, frequently used to assess individual progress during and after treatment. This study examined whether racial/ethnic disparities exist in employment after beginning treatment. It also examined the extent to which characteristics of clients' communities account for such disparities. Analyses are based on data that linked individual treatment information from Washington State's Behavioral Health Administration with employment data from the state's Employment Security Department...
April 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29465673/healthcare-provider-perceptions-of-a-sexually-transmitted-infection-self-testing-program-in-an-hiv-care-clinic
#17
Susana Tat, Shireesha Dhanireddy, Jeanne M Marrazzo, Lindley A Barbee
BACKGROUND: Sexually transmitted infections (STI) disproportionately affect men who have sex with men (MSM). While clinical practice guidelines recommend routine STI screening of MSM who have high-risk behaviors, extragenital STI testing rates have been low in HIV clinics across the nation. The University of Washington STD Prevention Training Center implemented an STI self-testing program at a large HIV primary care clinic in Seattle, WA to facilitate extragenital STI testing. METHODS: We performed a mixed-methods program evaluation to assess healthcare provider acceptability of the program at nine months post implementation...
November 29, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29422165/evaluating-the-effectiveness-of-pre-operative-platelet-inhibition-testing-to-reduce-costs-and-pre-operative-length-of-stay
#18
Jennifer Bobbitt, Kathleen Petro, Michael Martin
This was a retrospective study to assess the effectiveness of Society of Thoracic Surgeons (STS) Guidelines in reducing resource utilization at Washington Adventist Hospital, Takoma Park, Maryland. Pre and post operative stay (days), platelets and other blood product use, along with hospital costs were compared in elective Cardiac Surgical patients receiving P2Y12 inhibitors in the year prior to and year following the implementation of the STS guidelines of preoperative monitoring of platelet inhibition with VerifyNow...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29410142/a-randomized-multi-center-study-assessing-the-educational-impact-of-a-computerized-interactive-hysterectomy-trainer-on-gynecology-residents
#19
Allan S Lichtman, William Parker, Barbara Goff, Neeraj Mehra, Eliane M Shore, Guylaine Lefebvre, Alexander Chiang, John Lenihan, Henk W R Schreuder
STUDY OBJECTIVE: To assess improvement of cognitive surgical knowledge of laparoscopic hysterectomy in post-graduate year (PGY) 1 and 2 gynecology residents who used an interactive computer-based Laparoscopic Hysterectomy Trainer. DESIGN: Multicenter prospective, randomized, controlled study (Canadian Taskforce Classification I). SETTING: Five Departments of Obstetrics and Gynecology: Keck School of Medicine of USC; University of California-Los Angeles; University of Washington; University of British Columbia; University of Toronto...
February 1, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29409555/seattle-s-minimum-wage-ordinance-did-not-affect-supermarket-food-prices-by-food-processing-category
#20
Amanda L Spoden, James H Buszkiewicz, Adam Drewnowski, Mark C Long, Jennifer J Otten
OBJECTIVE: To examine the impacts of Seattle's minimum wage ordinance on food prices by food processing category. DESIGN: Supermarket food prices were collected for 106 items using a University of Washington Center for Public Health Nutrition market basket at affected and unaffected supermarket chain stores at three times: March 2015 (1-month pre-policy enactment), May 2015 (1-month post-policy enactment) and May 2016 (1-year post-policy enactment). Food items were categorized into four food processing groups, from minimally to ultra-processed...
February 7, 2018: Public Health Nutrition
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