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https://www.readbyqxmd.com/read/29033802/the-neurobiological-mechanism-of-chemical-aversion-emetic-therapy-for-alcohol-use-disorder-an-fmri-study
#1
Ralph L Elkins, Todd L Richards, Robert Nielsen, Richard Repass, Henriettae Stahlbrandt, Hunter G Hoffman
A recent NIH epidemiology study found the lifetime prevalence of alcohol use disorder in the United States to be 29%. Alcohol drinking behavior is strongly "learned" via pleasure center activation/reinforcement. Alcohol craving is a powerful desire to drink alcoholic beverages. Craving was added as one of the defining criteria for alcohol use disorder in DSM5, and craving reduction is becoming an increasingly important treatment goal. In the current study, patients with alcohol use disorder received 10 days of inpatient multi-modal treatments at Schick Shadel Hospital (SSH) of Seattle...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29030020/the-trajectory-of-positive-psychological-change-in-a-head-and-neck-cancer-population
#2
S A Harding
A stressful event may be sufficient to challenge a strongly held set of assumptions about the world and the self. In some people this may lead to post-traumatic stress disorder (PTSD) and in others to positive psychological change (PPC), whereby a person's reactions to the challenge are beneficial. Little research has investigated PPC in people who have had head and neck cancer (HNC). The aim of this study was to identify demographic, clinical, and psychological factors associated with PPC over time. A cross-sequential study collected data over 5 years...
October 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28967447/comfort%C3%A2-sm-communication-for-oncology-nurses-program-overview-and-preliminary-evaluation-of-a-nationwide-train-the-trainer-course
#3
Elaine Wittenberg, Betty Ferrell, Joy Goldsmith, Sandra L Ragan, Haley Buller
OBJECTIVE: The COMFORT Communication Course for Oncology Nurses is a train-the-trainer program funded by the National Cancer Institute (R25) that provides nationwide communication training to improve patient-centered communication in cancer care. The purpose of this article is to provide an overview of the program and present an evaluation of three courses. METHODS: The curriculum contains seven modules addressing palliative care communication. Pre-course survey of needs, post-course feedback, and follow-up at 6 and 12 months were used to evaluate the program...
September 22, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28943022/patient-reported-quality-of-life-outcomes-following-treatment-for-oral-cancer
#4
J Breeze, A Rennie, D Dawson, J Tipper, K-U Rehman, N Grew, N Pigadas
Patient-reported quality of life (QoL) outcomes have the potential to assist clinicians in providing individually tailored treatment decisions. QoL assessments were collected prospectively for 168 consecutive patients treated for oral cancer between 1 January 2010 and 31 December 2014 using the University of Washington Quality of Life Questionnaire. Patients were followed up for 18 months post-treatment. Sub-group analyses were performed using paired t-tests and analysis of variance (ANOVA) to compare the effects of adjunctive chemoradiotherapy, type of bone resection, and methods of soft and hard tissue flap reconstruction...
September 21, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28926727/early-pregnancy-intrauterine-fetal-exposure-to-maternal-smoking-and-impact-on-fetal-telomere-length
#5
Hooman Mirzakhani, Immaculata De Vivo, J Steven Leeder, Roger Gaedigk, Carrie A Vyhlidal, Scott T Weiss, Kelan Tantisira
BACKGROUND: Reduced telomere length, or its accelerated attrition, has been implicated in aging, mortality, and several human diseases, including respiratory diseases. Age dependent manifestation of telomere-mediated disease during life span indicates the role of developmental stage in these diseases and highlights the importance of fetal developmental process in utero and at earlier life stages. Environmental determinants during developmental and later stages of life could affect telomere length...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28886257/prevalence-and-causes-of-visual-impairment-in-fundong-district-north-west-cameroon-results-of-a-population-based-survey
#6
Joseph Oye, Islay Mactaggart, Sarah Polack, Elena Schmidt, Violet Tamo, Marvice Okwen, Hannah Kuper
PURPOSE: To estimate the prevalence and causes of visual impairment in Fundong Health District, North West Cameroon. METHODS: A total of 51 clusters of 80 people (all ages) were sampled with probability proportionate to size and compact segment sampling. Visual acuity (VA) was measured with a tumbling "E" chart. An ophthalmic nurse examined people with VA<6/18 in either eye. The presence of hearing and physical impairments were assessed using clinical examination, and self-reported visual problems using the Washington Group Short Set...
September 8, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28885557/evaluation-of-a-pilot-implementation-to-integrate-alcohol-related-care-within-primary-care
#7
Jennifer F Bobb, Amy K Lee, Gwen T Lapham, Malia Oliver, Evette Ludman, Carol Achtmeyer, Rebecca Parrish, Ryan M Caldeiro, Paula Lozano, Julie E Richards, Katharine A Bradley
Alcohol use is a major cause of disability and death worldwide. To improve prevention and treatment addressing unhealthy alcohol use, experts recommend that alcohol-related care be integrated into primary care (PC). However, few healthcare systems do so. To address this gap, implementation researchers and clinical leaders at Kaiser Permanente Washington partnered to design a high-quality Program of Sustained Patient-centered Alcohol-related Care (SPARC). Here, we describe the SPARC pilot implementation, evaluate its effectiveness within three large pilot sites, and describe the qualitative findings on barriers and facilitators...
September 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28845591/mitochondrial-degeneration-precedes-the-development-of-muscle-atrophy-in-progression-of-cancer-cachexia-in-tumour-bearing-mice
#8
Jacob L Brown, Megan E Rosa-Caldwell, David E Lee, Thomas A Blackwell, Lemuel A Brown, Richard A Perry, Wesley S Haynie, Justin P Hardee, James A Carson, Michael P Wiggs, Tyrone A Washington, Nicholas P Greene
BACKGROUND: Cancer cachexia is largely irreversible, at least via nutritional means, and responsible for 20-40% of cancer-related deaths. Therefore, preventive measures are of primary importance; however, little is known about muscle perturbations prior to onset of cachexia. Cancer cachexia is associated with mitochondrial degeneration; yet, it remains to be determined if mitochondrial degeneration precedes muscle wasting in cancer cachexia. Therefore, our purpose was to determine if mitochondrial degeneration precedes cancer-induced muscle wasting in tumour-bearing mice...
August 28, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28827206/relationship-between-gonadal-function-and-cardiometabolic-risk-in-young-men-with-chronic-spinal-cord-injury
#9
Shannon D Sullivan, Mark S Nash, Eshetu Tefara, Emily Tinsley, Suzanne Groah
BACKGROUND: We reported previously that young men with chronic spinal cord injury (SCI) have a greater prevalence of testosterone deficiency compared with an age-matched, healthy control population. Young men with SCI also are at increased risk for developing cardiometabolic dysfunction after injury. It is unclear whether testosterone deficiency is associated with heightened cardiometabolic risk in men with SCI. OBJECTIVE: To investigate associations among levels of testosterone in young men with chronic SCI and surrogate markers of cardiometabolic risk...
August 18, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28817335/killed-by-police-validity-of-media-based-data-and-misclassification-of-death-certificates-in-massachusetts-2004-2016
#10
Justin M Feldman, Sofia Gruskin, Brent A Coull, Nancy Krieger
OBJECTIVES: To assess the validity of demographic data reported in news media-based data sets for persons killed by police in Massachusetts (2004-2016) and to evaluate misclassification of these deaths in vital statistics mortality data. METHODS: We identified 84 deaths resulting from police intervention in 4 news media-based data sources (WGBH News, Fatal Encounters, The Guardian, and The Washington Post) and, via record linkage, conducted matched-pair analyses with the Massachusetts mortality data...
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28814328/building-capacity-for-dissemination-and-implementation-research-one-university-s-experience
#11
Ross C Brownson, Enola K Proctor, Douglas A Luke, Ana A Baumann, Mackenzie Staub, Matthew T Brown, Mallory Johnson
BACKGROUND: While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution...
August 16, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28797270/implementing-the-teen-marijuana-check-up-in-schools-a-study-protocol
#12
Bryan Hartzler, Aaron R Lyon, Denise D Walker, Lauren Matthews, Kevin M King, Kathryn E McCollister
BACKGROUND: Substance misuse is now encountered in settings beyond addiction specialty care, with schools a point-of-contact for student access to behavioral health services. Marijuana is a leading impetus for adolescent treatment admissions despite declining risk perception, for which the Teen Marijuana Check-Up (TMCU)-a tailored adaptation of motivational enhancement therapy-offers an efficacious service option. To bridge the knowledge gap concerning effective and affordable technical assistance strategies for implementing empirically supported services, the described trial will test such a strategy to facilitate school-based TMCU implementation...
August 10, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28776408/long-term-results-of-a-randomized-controlled-double-blind-study-of-low-level-laser-therapy-before-exercises-in-knee-osteoarthritis-laser-and-exercises-in-knee-osteoarthritis
#13
Patrícia Pereira Alfredo, Jan Magnus Bjordal, Washington Steagall Junior, Rodrigo Álvaro Brandão Lopes Martins, Martin B Stausholm, Raquel Aparecida Casarotto, Amélia Pasqual Marques, Jon Joensen
OBJECTIVES: To assess the long-term effects of low-level laser therapy (LLLT), in combination with strengthening exercises in patients with osteoarthritis of the knee. DESIGN: Follow-up results at three and six months in a previously published randomized, double-blind, placebo-controlled trial. SETTING: Specialist Rehabilitation Services. SUBJECTS: Forty participants of both genders, aged 50-75 years with knee osteoarthritis grade 2-4 on Kellgren-Lawrence scale...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28766984/long-term-effect-of-parasympathetic-or-sympathetic-denervation-on-intestinal-epithelial-cell-proliferation-and-apoptosis
#14
Elizabeth A Davis, Martha C Washington, Emily R Yaniz, Heidi Phillips, Ayman I Sayegh, Megan J Dailey
Intestinal epithelial tissue is constantly regenerated as a means to maintain proper tissue function. Previous studies have demonstrated that denervation of the parasympathetic or sympathetic nervous system to the intestine alters this process. However, results are inconsistent between studies, showing both increases and decreases in proliferation after denervation of the parasympathetic or sympathetic. The effect appears to correlate with (1) the timing post-denervation, (2) denervation-induced changes in food intake, (3) the denervation technique used, and (4) which intestinal segment is investigated...
September 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28728989/caution-with-use-of-the-expanded-prostate-cancer-index-composite-50-urinary-bother-scale-how-voiding-dysfunction-modifies-its-performance
#15
Lin Yang, Adam S Kibel, Graham A Colditz, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Robert L Grubb, Kathleen Y Wolin, Siobhan Sutcliffe
PURPOSE: We evaluated the agreement between patient-reported urinary function and bother, and sexual function and bother in radical prostatectomy (RP) patients to help inform possible non-functional, modifiable mechanisms for patient bother. METHODS: Patients were recruited from 2011-2014 at Washington University and Brigham & Women's Hospital. Urinary and sexual outcomes were assessed by the Expanded Prostate Cancer Index Composite-50 (EPIC-50) before, five weeks, and 12 months after RP...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28715105/a-simulation-based-approach-to-measuring-team-situational-awareness-in-emergency-medicine-a-multicenter-observational-study
#16
Elizabeth D Rosenman, Aurora J Dixon, Jessica M Webb, Sarah Brolliar, Simon J Golden, Kerin A Jones, Sachita Shah, James A Grand, Steve W J Kozlowski, Georgia T Chao, Rosemarie Fernandez
OBJECTIVES: Team situational awareness (TSA) is critical for effective teamwork and supports dynamic decision making in unpredictable, time-pressured situations. Simulation provides a platform for developing and assessing TSA, but these efforts are limited by suboptimal measurement approaches. The objective of this study was to develop and evaluate a novel approach to TSA measurement in interprofessional emergency medicine (EM) teams. METHODS: We performed a multicenter, prospective, simulation-based observational study to evaluate an approach to TSA measurement...
July 17, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28698343/protocol-for-an-observational-study-of-delirium-in-the-post-anaesthesia-care-unit-pacu-as-a-potential-predictor-of-subsequent-postoperative-delirium
#17
Victoria Cui, Catherine M Tedeschi, Vanessa L Kronzer, Sherry L McKinnon, Michael S Avidan
INTRODUCTION: Postoperative delirium can be a serious consequence of major surgery, associated with longer hospital stays, readmission, cognitive and functional deterioration and mortality. Delirium is an acute, reversible disorder characterised by fluctuating course, inattention, disorganised thinking and altered level of consciousness. Delirium occurring in the hours immediately following anaesthesia and delirium occurring in the postoperative period of 1-5 days have been described as distinct clinical entities...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28640679/crash-fatality-rates-after-recreational-marijuana-legalization-in-washington-and-colorado
#18
Jayson D Aydelotte, Lawrence H Brown, Kevin M Luftman, Alexandra L Mardock, Pedro G R Teixeira, Ben Coopwood, Carlos V R Brown
OBJECTIVES: To evaluate motor vehicle crash fatality rates in the first 2 states with recreational marijuana legalization and compare them with motor vehicle crash fatality rates in similar states without recreational marijuana legalization. METHODS: We used the US Fatality Analysis Reporting System to determine the annual numbers of motor vehicle crash fatalities between 2009 and 2015 in Washington, Colorado, and 8 control states. We compared year-over-year changes in motor vehicle crash fatality rates (per billion vehicle miles traveled) before and after recreational marijuana legalization with a difference-in-differences approach that controlled for underlying time trends and state-specific population, economic, and traffic characteristics...
August 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28631870/thalamic-deep-brain-stimulation-for-neuropathic-pain-efficacy-at-three-years-follow-up
#19
Vasco Abreu, Rui Vaz, Virgínia Rebelo, Maria José Rosas, Clara Chamadoira, Martin J Gillies, Tipu Z Aziz, Erlick A C Pereira
OBJECT: Chronic neuropathic pain is estimated to affect 3-4.5% of the worldwide population, posing a serious burden to society. Deep Brain Stimulation (DBS) is already established for movement disorders and also used to treat some "off-label" conditions. However, DBS for the treatment of chronic, drug refractory, neuropathic pain, has shown variable outcomes with few studies performed in the last decade. Thus, this procedure has consensus approval in parts of Europe but not the USA. This study prospectively evaluated the efficacy at three years of DBS for neuropathic pain...
July 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28621924/revealing-the-crystalline-integrity-of-wafer-scale-graphene-on-sio2-si-an-azimuthal-rheed-approach
#20
Zonghuan Lu, Xin Sun, Yu Xiang, Morris A Washington, Gwo-Ching Wang, Toh-Ming Lu
The symmetry of graphene is usually determined by a low-energy electron diffraction (LEED) method when the graphene is on the conductive substrates, but LEED cannot handle graphene transferred to SiO2/Si substrates due to the charging effect. While transmission electron microscopy can generate electron diffraction on post-transferred graphene, this method is too localized. Herein, we employed an azimuthal reflection high-energy electron diffraction (RHEED) method to construct the reciprocal space mapping and determine the symmetry of wafer-size graphene both pre- and post-transfer...
July 12, 2017: ACS Applied Materials & Interfaces
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