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https://www.readbyqxmd.com/read/29161417/bolus-weekly-vitamin-d3-supplementation-impacts-gut-and-airway-microbiota-in-adults-with-cystic-fibrosis-a-double-blind-randomized-placebo-controlled-clinical-trial
#1
Mansi Kanhere, Jiabei He, Benoit Chassaing, Thomas R Ziegler, Jessica A Alvarez, Elizabeth A Ivie, Li Hao, John Hanfelt, Andrew T Gewirtz, Vin Tangpricha
Background: Disruption of gut microbiota may exacerbate severity of cystic fibrosis (CF). Vitamin D deficiency is a common co-morbidity in patients with CF that may influence composition of the gut microbiota. Objectives: Compare microbiota of vitamin D sufficient and insufficient CF patients, and assess impact of a weekly high-dose vitamin D3 bolus regimen on gut and airway microbiome in adults with CF and vitamin D insufficiency (25(OH)D <30 ng/mL). Design: Forty-one subjects with CF were classified into two groups - vitamin D insufficient (n=23) and vitamin D sufficient (n=18)...
November 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29161402/fit-for-surgery-perspectives-on-preoperative-exercise-testing-and-training
#2
K Richardson, D Z H Levett, S Jack, M P W Grocott
There is a consistent relationship between physical activity, physical fitness, and health across almost all clinical contexts, including the perioperative setting. Physiological measurements obtained during physical exercise may be used to infer the risk of adverse outcome after major surgery. In particular, data obtained from perioperative cardiopulmonary exercise testing have an expanding role in perioperative care. Such information may be used to inform a variety of changes in clinical practice, including interventions that may reduce the risk of perioperative adverse events...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29159733/management-of-hemophilia-in-older-patients
#3
REVIEW
Massimo Franchini, Pier Mannuccio Mannucci
In recent decades, several improvements in hemophilia care have resulted in increased quality of life and life expectancy for those affected by this inherited hemorrhagic condition. Nowadays, individuals with hemophilia enjoy a life expectancy at birth close to that of males in the general population. As a consequence of the increasing age of the hemophilia population, a growing number of these patients develop age-related co-morbidities, such as cardiovascular disease and cancer, the management of which represents a new challenge for caregivers at hemophilia treatment centers...
November 20, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29159509/the-role-of-socio-demographic-factors-in-depression-and-anxiety-of-patients-on-hemodialysis-an-observational-cross-sectional-study
#4
G Gerogianni, E Lianos, A Kouzoupis, M Polikandrioti, E Grapsa
PURPOSE: Depression and anxiety have high prevalence in patients on hemodialysis and are strongly associated with socio-economic factors. The aim of this study was to evaluate the prevalence of depression and anxiety in hemodialyzed patients in Greece and its association with socio-demographic factors. METHODS: Four hundred and fourteen (414) patients on hemodialysis (262 males and 152 females) from 24 dialysis centers in Greece participated in this observational cross-sectional study...
November 20, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29158990/increased-risk-of-periodontitis-in-patients-with-psoriatic-disease-a-nationwide-population-based-retrospective-cohort-study
#5
Ni-Yu Su, Jing-Yang Huang, Chien-Jen Hu, Hui-Chieh Yu, Yu-Chao Chang
Aims: Periodontitis and psoriatic disease, including psoriasis (PS) and psoriatic arthritis (PsA), share the common risk factors and co-morbidities. However, the risk of periodontitis in patients with psoriatic disease still needs further investigation. This study was a nationwide population-based retrospective cohort study assessing the risk of periodontitis from psoriatic disease exposure. Materials and Methods: Patients with newly diagnosed psoriatic disease from 2003 to 2012 were identified from the Taiwanese National Health Insurance Research Database...
2017: PeerJ
https://www.readbyqxmd.com/read/29157960/immune-responses-to-intradermal-and-intramuscular-inactivated-influenza-vaccine-among-older-age-group
#6
Kobporn Boonnak, Jittima Dhitavat, Narumon Thantamnu, Nathamon Kosoltanapiwat, Montida Auayporn, Li Jiang, Pilaipan Puthavathana, Punnee Pitisuttithum
BACKGROUD: Influenza viruses cause substantial morbidity, especially in older age groups. Thus, they are amongst high priority groups for routine vaccination. However, vaccine-induced immune responses and effectiveness were reported as relatively low. This study aims to systemically compare the immune responses elicited by intramuscular (IM) and intradermal (ID) injections with inactivated seasonal influenza vaccine among the older age group. METHODS: A prospective, open-label, randomized study with a total of 221 adults (>60 years) were enrolled and randomized into 2 groups...
November 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29157786/the-seasonal-variability-of-surgical-site-infections-in-knee-and-hip-arthroplasty
#7
Chris A Anthony, Ryan A Peterson, Daniel K Sewell, Linnea A Polgreen, Jacob E Simmering, John J Callaghan, Philip M Polgreen
BACKGROUND: Surgical site infections (SSIs) after total knee (TKA) and total hip (THA) arthroplasty are devastating to patients and costly to healthcare systems. The purpose of this study is to investigate the seasonality of TKA and THA SSIs at a national level. METHODS: All data were extracted from the National Readmission Database for 2013 and 2014. Patients were included if they had undergone TKA or THA. We modeled the odds of having a primary diagnosis of SSI as a function of discharge date by month, payer status, hospital size, and various patient co-morbidities...
November 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29157068/quadrivalent-inactivated-influenza-vaccine-vaxigriptetra%C3%A2
#8
Viviane Gresset-Bourgeois, Phillip S Leventhal, Stéphanie Pepin, Rosalind Hollingsworth, Marie-Pierre Kazek-Duret, Iris De Bruijn, Sandrine I Samson
VaxigripTetra™ (IIV4; Sanofi Pasteur) is a quadrivalent split-virion influenza vaccine approved in Europe in 2016 for individuals ≥ 3 years of age. IIV4 builds on the well-established record of the trivalent split-virion influenza vaccine (Vaxigrip®). Areas covered: This literature review summarizes the rationale for developing quadrivalent influenza vaccines and discusses the phase III clinical trial results supporting the immunogenicity, safety, and tolerability of IIV4. Expert Commentary: IIV4 is immunogenic and well tolerated...
November 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29156017/early-and-late-outcomes-after-surgical-repair-of-congenital-supravalvular-aortic-stenosis-a-european-congenital-heart-surgeons-association-multicentric-study
#9
Massimo A Padalino, Anna Chiara Frigo, Marina Comisso, Martin Kostolny, Ikenna Omeje, Christian Schreiber, Jelena Pabst von Ohain, Julie Cleuziou, David J Barron, Bart Meyns, Viktor Hraska, Bohdan Maruszewski, Michal Kozlowski, Luca A Vricella, Narutoshi Hibino, Sarah Collica, Hakan Berggren, Mats Synnergren, Stojan Lazarov, David Kalfa, Emile Bacha, Christian Pizarro, Mark Hazekamp, Vlado Sojak, Jeffrey P Jacobs, Matej Nosal, Jose Fragata, Sertac Cicek, George E Sarris, Panayotis Zografos, Vladimiro L Vida, Giovanni Stellin
OBJECTIVES: Our goal was to evaluate the early and late results of the surgical management of congenital supravalvular aortic stenosis (SVAS). METHODS: We performed a retrospective, multicentre study using data from the European Congenital Heart Surgeons Association. Exclusion criteria were age >18 years, operation before 1990 and redo supravalvular aortic stenosis operations. Multivariate Cox regression analysis was performed to detect independent predictors of adverse events...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155555/medication-exposure-in-highly-adherent-psychiatry-patients
#10
Jeffrey J Sutherland, Thomas M Daly, Karen Jacobs, Elias A Khawam, Leo Pozuelo, Ryan D Morrison, Stephen B Milne, J Scott Daniels, Timothy Patrick Ryan
Medication exposure is dependent upon many factors, the single most important being if the patient took the prescribed medication as indicated. To assess medication exposure for psychotropic and other medication classes, we enrolled 115 highly adherent psychiatry patients prescribed five or more medications. In these patients, we measured 21 psychotropic and 38 non-psychotropic medications comprising a 59-medication multiplex assay panel. Strict enrollment criteria and reconciliation of the electronic health record medication list prior to study initiation produced a patient cohort that was compliant with 91% of their prescribed medications as determined by comparing medications detected empirically in blood to the electronic health record medication list...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29154830/understanding-mechanisms-to-promote-successful-aging-in-persons-living-with-hiv
#11
REVIEW
Gerome V Escota, Jane A O'Halloran, William G Powderly, Rachel M Presti
The mortality rate associated with HIV infection plummeted after the introduction of effective antiretroviral therapy pioneered two decades ago.As a result, HIV-infected people now have a life expectancy comparable to that of HIV-uninfected individuals. Despite this, increased rates of osteoporosis, chronic liver disease, and in particular cardiovascular disease have been reported among people living with HIV infection. With the aging HIV-infected population, the burden of these co-morbid illnesses may continue to accrue over time...
November 14, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29154055/complementary-and-alternative-medicine-use-among-elderly-patients-living-with-chronic-diseases-in-a-teaching-hospital-in-ethiopia
#12
Asnakew Achaw Ayele, Henok Getachew Tegegn, Kaleab Taye Haile, Sewunet Admasu Belachew, Amanual Getnet Mersha, Daniel Asfaw Erku
BACKGROUND: The use of complementary and alternative medicine (CAM) among patients with chronic diseases has grown rapidly worldwide. Yet, little has been known about CAM use by elderly patients with chronic diseases in Ethiopia. This study aimed at assessing the prevalence and reasons for CAM utilization among elderly patients living with chronic diseases in Ethiopia. METHODS: An institution-based quantitative cross-sectional survey was conducted among elderly patients with chronic disease attending outpatient ambulatory clinics of University of Gondar referral and teaching hospital (UoGRTH)...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29153825/clinician-and-manager-perceptions-of-factors-leading-to-ward-patient-clinical-deterioration
#13
Joshua Allen, Daryl Jones, Judy Currey
BACKGROUND: Improving the timely recognition and response to clinical deterioration is a critical challenge for clinicians, educators, administrators and researchers. Clinical deterioration leading to Rapid Response Team review is associated with poor patient outcomes. A range of factors associated with clinical deterioration and its outcomes have been identified, and may help with early identification of deteriorating patients. However, the relative importance of each factor on the development of clinical deterioration is unknown...
November 16, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29153686/progression-of-gestational-hypertension-to-pre-eclampsia-a-cohort-study-of-20-103-pregnancies
#14
Kuo-Hu Chen, Kok-Min Seow, Li-Ru Chen
OBJECTIVE: To investigate previously un-identified risk factors for the progression of gestational hypertension (GH) to pre-eclampsia (PE) by considering Grade III preterm placental calcification (PPC) and excessive weight gain (≧10kgw) at 28weeks gestation. METHODS: At a tertiary teaching hospital, obstetric ultrasonography was performed at 28weeks gestation to establish a diagnosis of grade III PPC. Weight gain during pregnancy was recorded at the same time...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153684/impact-of-maternal-serum-uric-acid-on-perinatal-outcome-in-women-with-hypertensive-disorders-of-pregnancy-a-prospective-study
#15
Naina Kumar, Amit Kant Singh, Bhavya Maini
INTRODUCTION: Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. AIM: To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. METHODOLOGY: Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153379/bariatric-patients-reported-motivations-for-surgery-and-their-relationship-to-weight-status-and-health
#16
Jessica C Peacock, Levi Perry, Kyle Morien
BACKGROUND: Literature on patient motivation for bariatric surgery remains limited. A few studies have examined relation to outcomes and found no established connection between motivation and weight loss. SETTING: A retrospective convenience sample of 345 participants was recruited from an obesity support website to complete an online survey. METHODS: Content analysis was used to describe motivations for surgery, and analysis of variance and covariance were completed to compare groups of participants created from the qualitative analysis on pre- and postsurgical factors like body mass index, number of co-morbidities, and percentage of excess weight loss...
October 12, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29152783/comparison-of-sub-versus-suprafascially-raised-anterolateral-thigh-free-flaps-with-regard-to-donor-site-morbidity-function-and-aesthetics
#17
Sebastian Fischer, Yannick Diehm, Christoph Hirche, Thomas Kremer, Adrien Daigeler, Ulrich Kneser, J Frederick Hernekamp
BACKGROUND: Although the anterolateral thigh flap (ALT) is one of the most frequently applied free flaps in plastic surgery, it remains controversial if the flap should be raised in a sub- or suprafascial plane. The purpose of this study was to compare both harvest techniques regarding donor-site morbidity and outcomes. METHODS: We included 40 pair-matched patients, of whom 20 received a fasciocutaneous and 20 an adipocutaneous ALT free flap for extremity reconstruction...
November 20, 2017: Microsurgery
https://www.readbyqxmd.com/read/29152685/cerebral-palsy-an-overview
#18
REVIEW
Sheffali Gulati, Vishal Sondhi
Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. The clinical features of this entity evolve over time and the specific CP syndrome may be recognizable only after 3-5 y of age; although suggestive signs and symptoms may be present at an earlier age. The management involves neurological rehabilitation (addressing muscle tonal abnormalities, and devising physical and occupational therapies) and diagnosis and management of co-morbidities (including epilepsy, impairment of cognition, vision, hearing, and disturbances of growth and gastrointestinal function)...
November 20, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29151895/toll-like-receptor-4-differentially-mediates-intestinal-and-extra-intestinal-immune-responses-upon-multi-drug-resistant-pseudomonas-aeruginosa-association-of-il10-mice-with-chronic-colitis
#19
Anne Grunau, Ulrike Escher, Anja A Kühl, Stefan Bereswill, Markus M Heimesaat
Background: Infections with multi-drug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa (PA) have become a serious threat particularly in hospitalized patients with immunopathological co-morbidities. The well-balanced interplay between immune cells, pattern recognition receptors such as Toll-like receptor (TLR)-4 sensing lipopolysaccharide from Gram-negative bacteria including PA, and evolving pathways is crucial to prevent the host from invading (opportunistic) pathogens...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/29151281/skeletal-muscle-performance-and-ageing
#20
REVIEW
Michael Tieland, Inez Trouwborst, Brian C Clark
The world population is ageing rapidly. As society ages, the incidence of physical limitations is dramatically increasing, which reduces the quality of life and increases healthcare expenditures. In western society, ~30% of the population over 55 years is confronted with moderate or severe physical limitations. These physical limitations increase the risk of falls, institutionalization, co-morbidity, and premature death. An important cause of physical limitations is the age-related loss of skeletal muscle mass, also referred to as sarcopenia...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
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