Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Larissa Bartlett, James J R Brady, Maree Farrow, Sarang Kim, Aidan Bindoff, Hannah Fair, James C Vickers, Duncan Sinclair
INTRODUCTION: Containment measures implemented to minimize the spread of coronavirus disease 2019 (COVID-19) are reported to be negatively affecting mental health, diet, and alcohol consumption. These factors, as well as poor cardiometabolic health and insufficient physical and cognitive activity, are known to increase the risk of developing dementia. COVID-19 "lockdown" measures may have exacerbated these dementia risk factors among people in mid-to-later life. METHODS: We compared longitudinal data from before (October 2019) and during (April-June 2020) the first COVID-19 lockdown period in Tasmania, Australia...
2021: Alzheimer's & Dementia: Translational Research & Clinical Interventions
#22
JOURNAL ARTICLE
Y Lu, X Gwee, D Q Chua, T S Lee, W S Lim, M S Chong, P Yap, K B Yap, I Rawtaer, T M Liew, F Pan, T P Ng
BACKGROUND: Studies suggest that nutritional interventions using the whole diet approach such as the Mediterranean diet may delay cognitive decline and dementia onset. However, substantial numbers of older adults are non-adherent to any ideally healthy dietary pattern and are at risk of malnutrition. OBJECTIVE: The present study investigated the relationship between global malnutrition risk and onsets of cognitive decline and neurocognitive disorders (NCD), including mild cognitive impairment (MCI) or dementia in community-dwelling older adults...
2021: Journal of Nutrition, Health & Aging
#23
JOURNAL ARTICLE
Jessica Gong, Katie Harris, Maree Hackett, Sanne A E Peters, Henry Brodaty, Mark Cooper, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Stephen MacMahon, John Chalmers, Mark Woodward
AIM: To estimate the associations between risk factors and cognitive decline (CD)/dementia, and the sex differences in these risk factors in individuals with type 2 diabetes, while accounting for the competing risk of death. MATERIALS AND METHODS: The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial of 11,140 individuals with type 2 diabetes was used to estimate the odds of CD/dementia using multinomial logistic regression...
August 2021: Diabetes, Obesity & Metabolism
#24
REVIEW
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang, Steven H Liang
The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in steroidogenic cells. Brain TSPO expression is relatively low under physiological conditions, but is upregulated in response to glial cell activation. As the primary index of neuroinflammation, TSPO is implicated in the pathogenesis and progression of numerous neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), major depressive disorder (MDD) and obsessive compulsive disorder (OCD)...
February 2021: Acta Pharmaceutica Sinica. B
#25
JOURNAL ARTICLE
Mario Gil, Ney Alliey-Rodriguez, Juan Carlos Lopez-Alvarenga, Vincent Diego, Ciro A Gaona, Ledys Mata, Rosa V Pirela, Carlos A Chavez, Gabriel A de Erausquin, Jesus D Melgarejo, Gladys E Maestre
BACKGROUND: Neuropsychiatric symptoms play an important role in diagnosing and clinical follow-up of cognitive impairment and dementia. OBJECTIVE: We investigated the relationship between neuropsychiatric symptoms, cognitive impairment, and dementia in Hispanics. METHODS: We included 529 participants (age ≥40 years) from the Maracaibo Aging Study with standardized neuropsychiatric assessments, including the Neuropsychiatric Inventory (NPI)...
February 19, 2021: Journal of Alzheimer's Disease: JAD
#26
JOURNAL ARTICLE
Donna Wilcock, Gregory Jicha, Deborah Blacker, Marilyn S Albert, Lina M D'Orazio, Fanny M Elahi, Myriam Fornage, Jason D Hinman, Janice Knoefel, Joel Kramer, Richard J Kryscio, Melissa Lamar, Abhay Moghekar, Jillian Prestopnik, John M Ringman, Gary Rosenberg, Abhay Sagare, Claudia L Satizabal, Julie Schneider, Sudha Seshadri, Sandeepa Sur, Russell P Tracy, Sevil Yasar, Victoria Williams, Herpreet Singh, Lidiya Mazina, Karl G Helmer, Roderick A Corriveau, Kristin Schwab, Pia Kivisäkk, Steven M Greenberg
The concept of vascular contributions to cognitive impairment and dementia (VCID) derives from more than two decades of research indicating that (1) most older individuals with cognitive impairment have post mortem evidence of multiple contributing pathologies and (2) along with the preeminent role of Alzheimer's disease (AD) pathology, cerebrovascular disease accounts for a substantial proportion of this contribution. Contributing cerebrovascular processes include both overt strokes caused by etiologies such as large vessel occlusion, cardioembolism, and embolic infarcts of unknown source, and frequently asymptomatic brain injuries caused by diseases of the small cerebral vessels...
April 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#27
RANDOMIZED CONTROLLED TRIAL
Joanna Rymaszewska, Katarzyna M Lion, Bartłomiej Stańczykiewicz, Julia E Rymaszewska, Elżbieta Trypka, Lilla Pawlik-Sobecka, Izabela Kokot, Sylwia Płaczkowska, Agnieszka Zabłocka, Dorota Szcześniak
BACKGROUND: Whole-body cryotherapy (WBC) - a repetitive, short-term exposure to extremely low temperatures - may become an effective early intervention for mild cognitive impairment (MCI). It is a heterogeneous group of symptoms associated with cognitive dysfunction which is estimated to transform into dementia in 50% cases. STUDY DESIGN: The prospective randomised double-blind sham-controlled study aimed to determine the efficacy of WBC on cognitive functioning and biological mechanisms...
April 2021: Experimental Gerontology
#28
JOURNAL ARTICLE
Joyce Vrijsen, Ameen Abu-Hanna, Els Lm Maeckelberghe, Peter Paul De Deyn, Andrea F de Winter, Fransje E Reesink, Richard C Oude Voshaar, Erik Buskens, Sophia E de Rooij, Nynke Smidt
INTRODUCTION: Descendants of patients with dementia have a higher risk to develop dementia. This study aims to investigate the uptake and effectiveness of an online tailor-made lifestyle programme for dementia risk reduction (DRR) among middle-aged descendants of people with recently diagnosed late-onset dementia. METHODS AND ANALYSIS: Demin is a cluster randomised controlled trial, aiming to include 21 memory clinics of which 13 will be randomly allocated to the passive (poster and flyer in a waiting room) and 8 to the active recruitment strategy (additional personal invitation by members of the team of the memory clinic)...
October 16, 2020: BMJ Open
#29
JOURNAL ARTICLE
Angelica Miki Stein, Thays Martins Vital da Silva, Flávia Gomes de Melo Coelho, André Veloso Rueda, Rosana Camarini, Ruth Ferreira Santos Galduróz
OBJECTIVES: Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer's disease (AD). There is a need to investigate the IGF-1 response to exercise in AD patients due to well-known potential effects of exercise on IGF-1. The aim of this study was to examine circulating IGF-1 levels in AD patients and older adults without dementia after acute exercise and to verify the associations among cardiorespiratory fitness, cognition and IGF-1 levels...
January 1, 2021: Behavioural Brain Research
#30
JOURNAL ARTICLE
Sangwoo Ahn, Michelle A Mathiason, Ruth Lindquist, Fang Yu
Episodic memory is affected early in the neuropathological process of Alzheimer's dementia. This study was performed to identify longitudinal associations between baseline vascular/neuropsychiatric risk factors and episodic memory changes over 4.1 ± 2.4 years in 1,401 older adults with subjective cognitive decline (age 74.0 ± 8.2 years). Data were from the National Alzheimer's Coordinating Center-Uniform Data Set and linear mixed effects regression models were used. Reference was those without risk factors...
January 2021: Geriatric Nursing
#31
JOURNAL ARTICLE
Kyu-Tae Han, Seung Ju Kim
OBJECTIVES: As aging progresses, older adults experience several health changes, including changes in cholesterol levels, which increases their risk for other diseases. Older adults are particularly vulnerable to cognitive impairment and depression, which may be due to several factors. The aim of this study was to evaluate the association between serum cholesterol level and cognitive impairment and depression in older adults. METHODS: This study used senior cohort data from the National Health Insurance Service of South Korea...
January 2021: International Journal of Geriatric Psychiatry
#32
REVIEW
Antonio Cano, Skye Marshall, Irene Zolfaroli, Johannes Bitzer, Iuliana Ceausu, Peter Chedraui, Fatih Durmusoglu, Risto Erkkola, Dimitrios G Goulis, Angelica Lindén Hirschberg, Ludwig Kiesel, Patrice Lopes, Amos Pines, Mick van Trotsenburg, Irene Lambrinoudaki, Margaret Rees
INTRODUCTION: Globally, 985 million women are aged 50 and over, leading to increasing concerns about chronic conditions such as cardiovascular disease, osteoporosis, dementia, and cognitive decline, which can adversely affect quality of life and independent living. AIM: To evaluate the evidence from observational studies and randomized trials on the effects of the Mediterranean diet on short- and long-term menopausal health: estrogen deficiency symptoms, cardiovascular disease, osteoporosis, cognitive and mental health, breast cancer, and all-cause mortality...
September 2020: Maturitas
#33
JOURNAL ARTICLE
Karina Mayagoitia, Sam D Shin, Marsilio Rubini, Lorraine Siebold, Christopher G Wilson, Denise L Bellinger, Johnny D Figueroa, Salvador Soriano
Alzheimer's disease (AD) is a neurodegenerative condition associated with loss of memory function, depression and anxiety. The etiology of AD is poorly understood, but both cholesterol dyshomeostasis and dysregulation of the immune system are contributing factors. Current evidence is consistent with a detrimental effect of excess cholesterol on neuroinflammation, both in mouse models of memory loss and in dementia in humans. However, whether the impact of cholesterol on neuroinflammation occurs early and contributes to pathogenesis of the disease or simply reflects a pleiotropic impact at advanced stages of disease is unclear...
June 22, 2020: Behavioural Brain Research
#34
JOURNAL ARTICLE
Sander Lamballais, Ryan L Muetzel, Mohammad Arfan Ikram, Henning Tiemeier, Meike W Vernooij, Tonya White, Hieab H H Adams
Background: Genetics play a significant role in the etiology of late-life neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. Part of the individual differences in risk for these diseases can be traced back decades before the onset of disease symptoms. Previous studies have shown evidence for plausible links of apolipoprotein E (APOE), the most important genetic marker for Alzheimer's disease, with early-life cognition and neuroimaging markers...
2020: Frontiers in Psychiatry
#35
JOURNAL ARTICLE
Yuda Turana, Darren M Lipnicki, Yvonne S Handajani, Tara P Sani, Josephine R Widayanti, Ika Suswanti, Nicole A Kochan, Henry Brodaty, Perminder S Sachdev
BACKGROUND AND AIMS: Among older adults, olfactory dysfunction is associated with cognitive impairment, lower quality of life, and increased mortality. While age is a risk factor for olfactory dysfunction, other risk factors are less well understood, and may vary between ethno-regional groups. This study investigated how associations between odour identification (OI) and various risk factors, as well as cognition and language ability, differed or were similar in two distinct ethno-regional groups of older adults...
November 21, 2019: Aging Clinical and Experimental Research
#36
MULTICENTER STUDY
Darren M Lipnicki, Steve R Makkar, John D Crawford, Anbupalam Thalamuthu, Nicole A Kochan, Maria Fernanda Lima-Costa, Erico Castro-Costa, Cleusa Pinheiro Ferri, Carol Brayne, Blossom Stephan, Juan J Llibre-Rodriguez, Jorge J Llibre-Guerra, Adolfo J Valhuerdi-Cepero, Richard B Lipton, Mindy J Katz, Carol A Derby, Karen Ritchie, Marie-Laure Ancelin, Isabelle Carrière, Nikolaos Scarmeas, Mary Yannakoulia, Georgios M Hadjigeorgiou, Linda Lam, Wai-Chi Chan, Ada Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Seung Wan Suh, Steffi G Riedel-Heller, Susanne Roehr, Alexander Pabst, Martin van Boxtel, Sebastian Köhler, Kay Deckers, Mary Ganguli, Erin P Jacobsen, Tiffany F Hughes, Kaarin J Anstey, Nicolas Cherbuin, Mary N Haan, Allison E Aiello, Kristina Dang, Shuzo Kumagai, Tao Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Ma Shwe Zin Nyunt, Marcia Scazufca, Henry Brodaty, Katya Numbers, Julian N Trollor, Kenichi Meguro, Satoshi Yamaguchi, Hiroshi Ishii, Antonio Lobo, Raul Lopez-Anton, Javier Santabárbara, Yvonne Leung, Jessica W Lo, Gordana Popovic, Perminder S Sachdev
BACKGROUND: With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. METHODS AND FINDINGS: We harmonized longitudinal data from 20 population-based cohorts from 15 countries over 5 continents, including 48,522 individuals (58...
July 2019: PLoS Medicine
#37
JOURNAL ARTICLE
Hee-Yeon Shin, Jeong-Hwa Kim, Geon-Ho Jahng, Woo-Sang Jung, Seong-Uk Park, Chang-Nam Ko, Jung-Mi Park
BACKGROUND: Mild cognitive impairment (MCI) is an intermediate phase between normal aging and dementia. Since a majority of amnestic MCI (aMCI) cases progress to Alzheimer's disease (AD), it is considered the prodromal stage of AD and, therefore, a treatment target for the prevention of further cognitive decline. However, there is no approved treatment for MCI at present. Kami Guibi-tang (KGT) is a herbal drug used in Korean medicine to treat amnesia, insomnia, loss of appetite, and depression...
July 22, 2019: Trials
#38
JOURNAL ARTICLE
Talaat A Abd Elaaty, Azza A Ismail, Hesham A Sheshtawy, Eman A Sultan, Mohamed G Ebrahim
CONTEXT: Depression, mild cognitive impairment, and dementia are highly prevalent chronic conditions associated with social, medical, and economic burdens. Although there are several epidemiological studies that have reported the prevalence of mild cognitive impairment or depressive syndrome in elderly diabetic population little is known about the comorbidity of these conditions. We aimed to study the prevalence of comorbid mild cognitive impairment (MCI) and depression in patients with Type 2 diabetes mellitus and its relation to glycemic control...
May 2019: Diabetes & Metabolic Syndrome
#39
JOURNAL ARTICLE
Galit Weinstein, Roni Elran Barak, Michal Schnaider Beeri, Ramit Ravona-Springer
OBJECTIVES: Personality may constitute an important domain of influence on cognitive function in old-adults. We assessed the relationship of personality traits and cognitive performance in individuals with Type-2 Diabetes (T2D), and explored possible mediators. METHOD: The sample includes 377 dementia-free subjects with T2D participating in the Israel Diabetes and Cognitive Decline study who underwent assessment of cognition and personality (mean age 72 ± 4y; 42% females)...
November 8, 2018: Aging & Mental Health
#40
JOURNAL ARTICLE
Panagiota Kontari, Kimberley J Smith
OBJECTIVES: Depression and cardiometabolic abnormalities are independently associated with a high risk of dementia. This study aimed to examine the association of comorbid depressive symptoms and cardiometabolic abnormalities with risk of dementia. METHODS: The sample comprised 4859 participants aged 50 or older without baseline dementia who took part in the English Longitudinal Study of Ageing (Waves 2-7). Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression tool...
October 29, 2018: International Journal of Geriatric Psychiatry
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
