keyword
MENU ▼
Read by QxMD icon Read
search

Leading four generations at work

keyword
https://www.readbyqxmd.com/read/29722446/transferability-and-within-and-between-laboratory-reproducibilities-of-episensa-for-predicting-skin-sensitization-potential-in-vitro-a-ring-study-in-three-laboratories
#1
Hideyuki Mizumachi, Megumi Sakuma, Mayu Ikezumi, Kazutoshi Saito, Midori Takeyoshi, Noriyasu Imai, Hiroko Okutomi, Asami Umetsu, Hiroko Motohashi, Mika Watanabe, Masaaki Miyazawa
The epidermal sensitization assay (EpiSensA) is an in vitro skin sensitization test method based on gene expression of four markers related to the induction of skin sensitization; the assay uses commercially available reconstructed human epidermis. EpiSensA has exhibited an accuracy of 90% for 72 chemicals, including lipophilic chemicals and pre-/pro-haptens, when compared with the results of the murine local lymph node assay. In this work, a ring study was performed by one lead and two naive laboratories to evaluate the transferability, as well as within- and between-laboratory reproducibilities, of EpiSensA...
May 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29680310/vocal-fold-contact-patterns-based-on-normal-modes-of-vibration
#2
Simeon L Smith, Ingo R Titze
The fluid-structure interaction and energy transfer from respiratory airflow to self-sustained vocal fold oscillation continues to be a topic of interest in vocal fold research. Vocal fold vibration is driven by pressures on the vocal fold surface, which are determined by the shape of the glottis and the contact between vocal folds. Characterization of three-dimensional glottal shapes and contact patterns can lead to increased understanding of normal and abnormal physiology of the voice, as well as to development of improved vocal fold models, but a large inventory of shapes has not been directly studied previously...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29601114/analysis-and-improvement-of-motion-encoding-in-magnetic-resonance-elastography
#3
Christian Guenthner, Jurgen Henk Runge, Ralph Sinkus, Sebastian Kozerke
Magnetic resonance elastography (MRE) utilizes phase contrast magnetic resonance imaging (MRI), which is phase locked to externally generated mechanical vibrations, to measure the three-dimensional wave displacement field. At least four measurements with linear-independent encoding directions are necessary to correct for spurious phase contributions if effects from imaging gradients are non-negligible. In MRE, three encoding schemes have been used: unbalanced four- and six-point and balanced four-point ('tetrahedral') encoding...
March 30, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29599394/improving-quality-and-safety-in-nursing-homes-and-home-care-the-study-protocol-of-a-mixed-methods-research-design-to-implement-a-leadership-intervention
#4
Siri Wiig, Eline Ree, Terese Johannessen, Torunn Strømme, Marianne Storm, Ingunn Aase, Berit Ullebust, Elisabeth Holen-Rabbersvik, Line Hurup Thomsen, Anne Torhild Sandvik Pedersen, Hester van de Bovenkamp, Roland Bal, Karina Aase
INTRODUCTION: Nursing homes and home care face challenges across different countries as people are living longer, often with chronic conditions. There is a lack of knowledge regarding implementation and impact of quality and safety interventions as most research evidence so far is generated in hospitals. Additionally, there is a lack of effective leadership tools for quality and safety improvement work in this context. METHODS AND ANALYSIS: The aim of the 'Improving Quality and Safety in Primary Care-Implementing a Leadership Intervention in Nursing Homes and Homecare' (SAFE-LEAD) study is to develop and evaluate a research-based leadership guide for managers to increase quality and safety competence...
March 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29575798/structural-and-functional-characterisation-of-multi-copper-oxidase-cueo-from-lignin-degrading-bacterium-ochrobactrum-sp-reveal-its-activity-towards-lignin-model-compounds-and-lignosulfonate
#5
Rommel Santiago Granja-Travez, Rachael C Wilkinson, Gabriela Felix Persinoti, Fabio M Squina, Vilmos Fülöp, Timothy D H Bugg
The identification of enzymes responsible for oxidation of lignin in lignin-degrading bacteria is of interest for biotechnological valorization of lignin to renewable chemical products. The genome sequences of two lignin-degrading bacteria, Ochrobactrum sp., and Paenibacillus sp., contain no B-type DyP peroxidases implicated in lignin degradation in other bacteria, but contain putative multi-copper oxidase genes. Multi-copper oxidase CueO from Ochrobactrum sp. was expressed and reconstituted as a recombinant laccase-like enzyme, and kinetically characterized...
March 25, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29494481/a-three-monoclonal-antibody-combination-potently-neutralizes-multiple-botulinum-neurotoxin-serotype-e-subtypes
#6
Consuelo Garcia-Rodriguez, Ali Razai, Isin N Geren, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J Smith, Jennifer L Brown, Janet C Skerry, Leonard A Smith, James D Marks
Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Libraries of yeast-displayed single chain Fv (scFv) antibodies were created from the heavy and light chain variable region genes of humans immunized with pentavalent-toxoid- and BoNT/E-binding scFv isolated by Fluorescence-Activated Cell Sorting (FACS). A total of 10 scFv were isolated that bound one or more BoNT/E subtypes with nanomolar-level equilibrium dissociation constants (KD )...
March 1, 2018: Toxins
https://www.readbyqxmd.com/read/29416942/nurse-designed-care-models-and-culture-of-health-review-of-three-case-studies
#7
Martsolf Grant, Mason Diana J, Sloan Jennifer, Sullivan Cheryl G, Villarruel Antonia M
The Robert Wood Johnson Foundation (RWJF) recently made a commitment to advancing a national culture of health (COH)-an action framework developed by RWJF that focuses on well-being and equity with the goal of empowering and supporting people to lead healthier lives where they live, learn, work, and play, now and in generations to come. Nurses are well positioned to provide care that is consistent with, and contributes to, a COH in their communities. RWJF contracted with the American Academy of Nursing (the Academy) with a subcontract to the RAND Corporation to explore the ways that innovative nurse-designed models of care are currently advancing a COH...
January 2018: Rand Health Quarterly
https://www.readbyqxmd.com/read/29353166/toxicological-responses-on-cytochrome-p450-and-metabolic-transferases-in-liver-of-goldfish-carassius-auratus-exposed-to-lead-and-paraquat
#8
Xiaoming Xu, Zhaojie Cui, Xinlei Wang, Xixin Wang, Su Zhang
As the producer of reactive oxygen species (ROS), both lead (Pb) and paraquat (PQ) can generate serious oxidative stress in target organs which result in irreversible toxic effects on organisms. They can disturb the normal catalytic activities of many enzymes by means of different toxicity mechanism. The changed responses of enzymes are frequently used as the biomarkers for indicating the relationship between toxicological effects and exposure levels. In this work, goldfish was exposed to a series of test groups containing lead and paraquat in the range of 0...
April 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#9
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
February 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29190509/genetic-determinants-of-freckle-occurrence-in-the-spanish-population-towards-ephelides-prediction-from-human-dna-samples
#10
Barbara Hernando, Maria Victoria Ibañez, Julio Alberto Deserio-Cuesta, Raquel Soria-Navarro, Inca Vilar-Sastre, Conrado Martinez-Cadenas
Prediction of human pigmentation traits, one of the most differentiable externally visible characteristics among individuals, from biological samples represents a useful tool in the field of forensic DNA phenotyping. In spite of freckling being a relatively common pigmentation characteristic in Europeans, little is known about the genetic basis of this largely genetically determined phenotype in southern European populations. In this work, we explored the predictive capacity of eight freckle and sunlight sensitivity-related genes in 458 individuals (266 non-freckled controls and 192 freckled cases) from Spain...
March 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29176812/generation-y-and-surgical-residency-passing-the-baton-or-the-end-of-the-world-as-we-know-it-results-from-a-survey-among-medical-students-in-germany
#11
Robert Kleinert, Claudia Fuchs, Vanessa Romotzky, Laura Knepper, Marie-Luise Wasilewski, Wolfgang Schröder, Christiane Bruns, Christiane Woopen, Jessica Leers
INTRODUCTION: The current student generation have their own expectations toward professional life and pay particular attention to their work-life balance. Less interest in work-intensive specialties leads to a shortage of skilled candidates especially in surgery. In order to motivate students into a surgical residency, new priorities become important. A deeper understanding of the underlying arguments and students' expectations towards a surgical training are necessary to counteract a future shortage of specialized surgeons...
2017: PloS One
https://www.readbyqxmd.com/read/29174684/food-wasters-profiling-consumers-attitude-to-waste-food-in-italy
#12
Silvia Gaiani, Sandra Caldeira, Valentina Adorno, Andrea Segrè, Matteo Vittuari
Scientific literature suggests that in developed countries food is predominantly wasted at the consumption stage of the food supply chain. This study aims to profile consumers' attitude to waste food in Italy investigating households' behaviours leading to food waste generation by addressing what is being wasted and why it is wasted. The work is based on a survey performed in Italy on a heterogeneous sample of 3,087 respondents. A cluster analysis was performed to detect consumers' profiles. Results, based on self-reporting, allow to sketch different 'waster' types, providing a picture of food waste related to eating, shopping, and storage behaviours and suggesting a number of differences existing in terms of perceived quantities and causes of generated food waste...
February 2018: Waste Management
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#13
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
December 2017: L'Encéphale
https://www.readbyqxmd.com/read/28977687/professional-structural-and-organisational-interventions-in-primary-care-for-reducing-medication-errors
#14
REVIEW
Hanan Khalil, Brian Bell, Helen Chambers, Aziz Sheikh, Anthony J Avery
BACKGROUND: Medication-related adverse events in primary care represent an important cause of hospital admissions and mortality. Adverse events could result from people experiencing adverse drug reactions (not usually preventable) or could be due to medication errors (usually preventable). OBJECTIVES: To determine the effectiveness of professional, organisational and structural interventions compared to standard care to reduce preventable medication errors by primary healthcare professionals that lead to hospital admissions, emergency department visits, and mortality in adults...
October 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28845341/building-a-national-culture-of-health-background-action-framework-measures-and-next-steps
#15
Anita Chandra, Joie Acosta, Katherine Grace Carman, Tamara Dubowitz, Laura Leviton, Laurie T Martin, Carolyn Miller, Christopher Nelson, Tracy Orleans, Margaret Tait, Matthew Trujillo, Vivian Towe, Douglas Yeung, Alonzo L Plough
Because health is a function of more than medical care, solutions to U.S. health problems must encompass more than reforms to health care systems. But those working to improve health, well-being, and equity still too often find themselves traveling on parallel paths that rarely intersect. In 2013, the Robert Wood Johnson Foundation (RWJF) embarked on a pioneering effort to advance a Culture of Health initiative. A Culture of Health places well-being at the center of every aspect of life, with the goal of enabling everyone in our diverse society to lead healthier lives, now and for generations to come...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28747496/parainfluenza-virus-5-expressing-wild-type-or-prefusion-respiratory-syncytial-virus-rsv-fusion-protein-protects-mice-and-cotton-rats-from-rsv-challenge
#16
Shannon I Phan, James R Zengel, Huiling Wei, Zhuo Li, Dai Wang, Biao He
Human respiratory syncytial virus (RSV) is the leading cause of pediatric bronchiolitis and hospitalizations. RSV can also cause severe complications in elderly and immunocompromised individuals. There is no licensed vaccine. We previously generated a parainfluenza virus 5 (PIV5)-vectored vaccine candidate expressing the RSV fusion protein (F) that was immunogenic and protective in mice. In this work, our goal was to improve the original vaccine candidate by modifying the PIV5 vector or by modifying the RSV F antigen...
October 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28634236/alternative-evolutionary-pathways-for-drug-resistant-small-colony-variant-mutants-in-staphylococcus-aureus
#17
Sha Cao, Douglas L Huseby, Gerrit Brandis, Diarmaid Hughes
Staphylococcus aureus is known to generate small colony variants (SCVs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. The SCV phenotype is unstable, and compensatory mutations lead to restored growth, usually with loss of resistance. However, the evolution of improved growth, by mechanisms that avoid loss of antibiotic resistance, is very poorly understood. By selection with serial passaging, we isolated and characterized different classes of extragenic suppressor mutations that compensate for the slow growth of small colony variants...
June 20, 2017: MBio
https://www.readbyqxmd.com/read/28631816/cognitive-rehabilitation-for-adults-with-traumatic-brain-injury-to-improve-occupational-outcomes
#18
REVIEW
K Suresh Kumar, Selvaraj Samuelkamaleshkumar, Anand Viswanathan, Ashish S Macaden
BACKGROUND: Cognitive impairment in people with traumatic brain injury (TBI) could affect multiple facets of their daily functioning. Cognitive rehabilitation brings about clinically significant improvement in certain cognitive skills. However, it is uncertain if these improved cognitive skills lead to betterments in other key aspects of daily living. We evaluated whether cognitive rehabilitation for people with TBI improves return to work, independence in daily activities, community integration and quality of life...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28621793/kinetics-and-mechanism-of-oxidation-of-the-anti-tubercular-prodrug-isoniazid-and-its-analog-by-iridium-iv-as-models-for-biological-redox-systems
#19
Jingran Dong, Yanli Ren, Sufang Sun, Jiao Yang, Chunxia Nan, Hongmei Shi, Jianzhong Xu, Jie Duan, Tiesheng Shi, Lars I Elding
A complex reaction mechanism of oxidation of the anti-tubercular prodrug isoniazid (isonicotinic hydrazide, INH) by [IrCl6 ]2- as a model for redox processes of such drugs in biological systems has been studied in aqueous solution as a function of pH between 0 and 8.5. Similar experiments have been performed with its isomer nicotinic hydrazide (NH). All reactions are overall second-order, first-order in [IrCl6 ]2- and hydrazide, and the observed second-order rate constants k' have been determined as a function of pH...
July 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28554062/an-isotope-dilution-uplc-ms-ms-technique-for-the-human-biomonitoring-of-the-internal-exposure-to-glycidol-via-a-valine-adduct-at-the-n-terminus-of-hemoglobin
#20
Jan Hielscher, Bernhard H Monien, Klaus Abraham, Sönke Jessel, Albrecht Seidel, Alfonso Lampen
Fatty acid esters of glycidol (glycidyl esters) are processing contaminants generated as a byproduct of the industrial deodorization of vegetable oils and fats. Oral intake of glycidyl esters leads to the release of glycidol in the gastrointestinal tract. Glycidol is carcinogenic, genotoxic and teratogenic in rodents. It is rated as probably carcinogenic to humans (IARC group 2A). The determination of internal exposure of glycidol may support the assessment of the possible human health risks related to glycidyl ester intake...
August 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
keyword
keyword
75322
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"