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https://www.readbyqxmd.com/read/27921338/melancholic-and-atypical-depression-as-predictor-and-moderator-of-outcome-in-cognitive-behavior-therapy-and-pharmacotherapy-for-adult-depression
#1
Pim Cuijpers, Erica Weitz, Femke Lamers, Brenda W Penninx, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Robin B Jarrett, Zindel V Segal, Steven D Hollon
BACKGROUND: Melancholic and atypical depression are widely thought to moderate or predict outcome of pharmacological and psychological treatments of adult depression, but that has not yet been established. This study uses the data from four earlier trials comparing cognitive behavior therapy (CBT) versus antidepressant medications (ADMs; and pill placebo when available) to examine the extent to which melancholic and atypical depression moderate or predict outcome in an "individual patient data" meta-analysis...
December 6, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27884096/recognizing-that-truth-is-unattainable-and-attending-to-the-most-informative-research-evidence
#2
Robert J DeRubeis, Lorenzo Lorenzo-Luaces
No abstract text is available yet for this article.
January 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/27846418/sudden-gains-in-routine-care-cognitive-behavioral-therapy-for-depression-a-replication-with-extensions
#3
Felix Wucherpfennig, Julian A Rubel, Steven D Hollon, Wolfgang Lutz
BACKGROUND: Over the last decade, a substantial amount of findings have been reported on the association between sudden gains (large symptom improvements in a between-session interval) and treatment outcome. Accurate replications of previous findings are needed to tackle inconsistencies and to shed light on the clinical implications of sudden gains. This study investigates whether similar effects of sudden gains can be expected under routine care conditions, when the patients are comparable to those examined in the original study by Tang and DeRubeis (1999)...
November 9, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/27805299/step-wise-loss-of-antidepressant-effectiveness-with-repeated-antidepressant-trials-in-bipolar-ii-depression
#4
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Robert J DeRubeis
OBJECTIVE: This study examined the relationship between the number of prior antidepressant treatment trials and step-wise increase in pharmacodynamic tolerance (or progressive loss of effectiveness) in subjects with bipolar II depression. METHODS: Subjects ≥18 years old with bipolar II depression (n=129) were randomized to double-blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six additional months...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27716513/specific-expectancies-are-associated-with-symptomatic-outcomes-and-side-effect-burden-in-a-trial-of-chamomile-extract-for-generalized-anxiety-disorder
#5
John R Keefe, Jay Amsterdam, Qing S Li, Irene Soeller, Robert DeRubeis, Jun J Mao
OBJECTIVE: Patient expectancies are hypothesized to contribute to the efficacy and side effects of psychiatric treatments, but little research has investigated this hypothesis in the context of psychopharmacological therapies for anxiety. We prospectively investigated whether expectancies predicted efficacy and adverse events in oral therapy for Generalized Anxiety Disorder (GAD), controlling for confounding patient characteristics correlating with outcomes. METHODS: Expectancies regarding treatment efficacy and side effects were assessed at baseline of an eight week open-label phase of a trial of chamomile for Generalized Anxiety Disorder (GAD)...
September 30, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27438078/specific-pharmacological-effects-of-paroxetine-comprise-psychological-but-not-somatic-symptoms-of-depression
#6
Benjamin D Schalet, Tony Z Tang, Robert J DeRubeis, Steven D Hollon, Jay D Amsterdam, Richard C Shelton
BACKGROUND: Meta-analyses of placebo-controlled trials of SSRIs suggest that only a small portion of the observable change in depression may be attributed to "true" pharmacological effects. But depression is a multidimensional construct, so treatment effects may differ by symptom cluster. We tested the hypothesis that SSRIs uniquely alter psychological rather than somatic symptoms of depression and anxiety. METHOD: Outpatients with moderate to severe MDD were randomly assigned to receive paroxetine (n = 120) or placebo (n = 60)...
2016: PloS One
https://www.readbyqxmd.com/read/27236074/positive-extreme-responding-after-cognitive-therapy-for-depression-correlates-and-potential-mechanisms
#7
Nicholas R Forand, Daniel R Strunk, Robert J DeRubeis
"Extreme responding" is the tendency to endorse extreme responses on self-report measures (e.g., 1s and 7s on a 7-point scale). It has been linked to depressive relapse after cognitive therapy (CT), but the mechanisms are unknown. Moreover, findings of positive extreme responding (PER) predicting depressive relapse do not support the original hypothesis of "extreme" negative thinking leading to extreme negative emotional reactions. We assessed the relationships between post-treatment PER on the Dysfunctional Attitudes Scale (DAS) and Attributional Style Questionnaire (ASQ) and these constructs: coping skills, in-session performance of cognitive therapy skills, age, and estimated IQ...
August 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/27097060/notice-of-retraction-and-replacement-hollon-et-al-effect-of-cognitive-therapy-with-antidepressant-medications-vs-antidepressants-alone-on-the-rate-of-recovery-in-major-depressive-disorder-a-randomized-clinical-trial-jama-psychiatry-2014-71-10-1157-1164
#8
Steven D Hollon, Robert J DeRubeis, Jan Fawcett, Jay D Amsterdam, Richard C Shelton, John Zajecka, Paula R Young, Robert Gallop
No abstract text is available yet for this article.
June 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27081644/symptom-management-during-and-after-treatment-with-concurrent-chemoradiotherapy-for-oropharyngeal-cancer-a-review-of-the-literature-and-areas-for-future-research
#9
REVIEW
Heidi Mason, Mary Beth DeRubeis, Nancy Burke, Melissa Shannon, Danielle Karsies, Gregory Wolf, Avi Eisbruch, Francis Worden
Patients with locally advanced oropharyngeal cancer are at risk for poor outcomes due to the multi-modal nature of treatment and the potential for treatment-related toxicity. Although treatment with concurrent chemotherapy and radiotherapy has drastically reduced the need for a debilitating and disfiguring surgery, treatment related toxicities are often difficult to control. Acute toxicities include mucositis, skin desquamation, depression, cachexia, fatigue and nausea and vomiting. Failure to control these symptoms can adversely affect the patient's ability to complete their treatment regimen...
April 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27065906/mediation-analysis-with-survival-outcomes-accelerated-failure-time-vs-proportional-hazards-models
#10
Lois A Gelfand, David P MacKinnon, Robert J DeRubeis, Amanda N Baraldi
OBJECTIVE: Survival time is an important type of outcome variable in treatment research. Currently, limited guidance is available regarding performing mediation analyses with survival outcomes, which generally do not have normally distributed errors, and contain unobserved (censored) events. We present considerations for choosing an approach, using a comparison of semi-parametric proportional hazards (PH) and fully parametric accelerated failure time (AFT) approaches for illustration...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/26892848/short-term-venlafaxine-v-lithium-monotherapy-for-bipolar-type-ii-major-depressive-episodes-effectiveness-and-mood-conversion-rate
#11
Jay D Amsterdam, Lorenzo Lorenzo-Luaces, Irene Soeller, Susan Qing Li, Jun J Mao, Robert J DeRubeis
BACKGROUND: Controversy exists over antidepressant use in bipolar II depression. AIMS: To compare the safety and effectiveness of antidepressantv.mood stabiliser monotherapy for bipolar type II major depressive episodes. METHOD: Randomised, double-blind, parallel-group, 12-week comparison of venlafaxine (n= 65)v.lithium (n= 64) monotherapy in adult out-patients (trial registration numberNCT00602537). RESULTS: Primary outcome - venlafaxine produced a greater response rate (67...
April 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26869246/divergent-outcomes-in-cognitive-behavioral-therapy-and-pharmacotherapy-for-adult-depression
#12
Jeffrey R Vittengl, Robin B Jarrett, Erica Weitz, Steven D Hollon, Jos Twisk, Ioana Cristea, Daniel David, Robert J DeRubeis, Sona Dimidjian, Boadie W Dunlop, Mahbobeh Faramarzi, Ulrich Hegerl, Sidney H Kennedy, Farzan Kheirkhah, Roland Mergl, Jeanne Miranda, David C Mohr, A John Rush, Zindel V Segal, Juned Siddique, Anne D Simons, Pim Cuijpers
OBJECTIVE: Although the average depressed patient benefits moderately from cognitive-behavioral therapy (CBT) or pharmacotherapy, some experience divergent outcomes. The authors tested frequencies, predictors, and moderators of negative and unusually positive outcomes. METHOD: Sixteen randomized clinical trials comparing CBT and pharmacotherapy for unipolar depression in 1,700 patients provided individual pre- and posttreatment scores on the Hamilton Depression Rating Scale (HAM-D) and/or Beck Depression Inventory (BDI)...
May 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/26849210/correction-predicting-optimal-outcomes-in-cognitive-therapy-or-interpersonal-psychotherapy-for-depressed-individuals-using-the-personalized-advantage-index-approach
#13
Marcus J H Huibers, Zachary D Cohen, Lotte H J M Lemmens, Arnoud Arntz, Frenk P M L Peeters, Pim Cuijpers, Robert J DeRubeis
No abstract text is available yet for this article.
2016: PloS One
https://www.readbyqxmd.com/read/26803764/rapid-versus-non-rapid-cycling-bipolar-ii-depression-response-to-venlafaxine-and-lithium-and-hypomanic-risk
#14
L Lorenzo-Luaces, J D Amsterdam, I Soeller, R J DeRubeis
OBJECTIVE: To examine the safety and effectiveness of antidepressant versus mood stabilizer monotherapy in rapid versus non-rapid cycling bipolar II disorder. METHOD: Subjects ≥18 years old with bipolar II depression (n = 129) were randomized to double-blind venlafaxine or lithium carbonate monotherapy for 12 weeks. Responders (n = 59) received continuation monotherapy for six additional months. RESULTS: Rapid cycling did not affect frequency of response or change over time in depressive symptoms...
June 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/26803276/sudden-gains-in-cognitive-therapy-and-interpersonal-psychotherapy-for-adult-depression
#15
Lotte H J M Lemmens, Robert J DeRubeis, Arnoud Arntz, Frenk P M L Peeters, Marcus J H Huibers
OBJECTIVE: We examined the rates, baseline predictors and clinical impact of sudden gains in a randomized comparison of individual Cognitive Therapy (CT) and Interpersonal Psychotherapy (IPT) for adult depression. METHOD: 117 depressed outpatients received 16-20 sessions of either CT or IPT. Session-by-session symptom severity was assessed using the BDI-II. Sudden gains were examined using the original criteria as defined by Tang and DeRubeis (1999b). Furthermore, we examined whether the duration of the between-session interval at which sudden gains were recorded affected the results...
February 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/26727410/in-cognitive-therapy-for-depression-early-focus-on-maladaptive-beliefs-may-be-especially-efficacious-for-patients-with-personality-disorders
#16
RANDOMIZED CONTROLLED TRIAL
John R Keefe, Christian A Webb, Robert J DeRubeis
OBJECTIVE: Patients with major depressive disorder (MDD) and a comorbid personality disorder (PD) have been found to exhibit relatively poor outcomes in cognitive therapy (CT) and other treatments. Adaptations of CT focusing heavily on patients' core beliefs have yielded promising findings in the treatment of PD. However, there have been no investigations that have specifically tested whether increased focus on maladaptive beliefs contributes to CT's efficacy for these patients. METHOD: CT technique use from an early CT session was assessed for 59 patients (33 without PD, 26 with PD-predominantly Cluster C) who participated in a randomized controlled trial for moderate to severe MDD...
April 2016: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/26562637/primary-care-physicians-selection-of-low-intensity-treatments-for-patients-with-depression
#17
Lorenzo Lorenzo-Luaces, Robert J DeRubeis, Ian M Bennett
BACKGROUND AND OBJECTIVES: Most outpatient treatment for depression is delivered by primary care physicians (PCPs), yet little is known about which patient variables affect PCPs' selection of high-intensity interventions, namely antidepressant medications or psychotherapy, as opposed to less-intensive treatment regimens (eg, watchful waiting, exercise). Our objective was to ascertain whether the patient's symptom severity, presenting psychosocial stress, and lifestyle habits influenced treatment recommendations...
July 2015: Family Medicine
https://www.readbyqxmd.com/read/26554707/predicting-optimal-outcomes-in-cognitive-therapy-or-interpersonal-psychotherapy-for-depressed-individuals-using-the-personalized-advantage-index-approach
#18
RANDOMIZED CONTROLLED TRIAL
Marcus J H Huibers, Zachary D Cohen, Lotte H J M Lemmens, Arnoud Arntz, Frenk P M L Peeters, Pim Cuijpers, Robert J DeRubeis
INTRODUCTION: Although psychotherapies for depression produce equivalent outcomes, individual patients respond differently to different therapies. Predictors of outcome have been identified in the context of randomized trials, but this information has not been used to predict which treatment works best for the depressed individual. In this paper, we aim to replicate a recently developed treatment selection method, using data from an RCT comparing the effects of cognitive therapy (CT) and interpersonal psychotherapy (IPT)...
2015: PloS One
https://www.readbyqxmd.com/read/26456895/differential-response-to-depression-prevention-among-a-sample-of-informal-caregivers-moderator-analysis-of-longer-term-follow-up-trial-data
#19
RANDOMIZED CONTROLLED TRIAL
Patricia Otero, Filip Smit, Pim Cuijpers, Robert J DeRubeis, Ángela Torres, Fernando L Vázquez
Depression is one of the most common mental disorders in caregivers. Therefore, preventive interventions for this population are needed, especially for caregivers with subclinical symptoms of depression. However, no study to date has identified the characteristics of caregivers that help to predict who will or will not benefit from such a preventive intervention. This study aimed to identify moderators of response to intervention comparing problem solving and usual care in indicated prevention of depression among informal caregivers...
December 15, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26214542/identifying-moderators-of-the-adherence-outcome-relation-in-cognitive-therapy-for-depression
#20
MULTICENTER STUDY
Katherine E Sasso, Daniel R Strunk, Justin D Braun, Robert J DeRubeis, Melissa A Brotman
OBJECTIVE: Little is known about the influence of patients' pretreatment characteristics on the adherence-outcome relation in cognitive therapy (CT) for depression. In a sample of 57 depressed adults participating in CT, the authors examined interactions between pretreatment patient characteristics and therapist adherence in predicting session-to-session symptom change. METHOD: Using items from the Collaborative Study Psychotherapy Rating Scale, the authors assessed 3 facets of therapist adherence: cognitive methods, negotiating/structuring, and behavioral methods/homework...
October 2015: Journal of Consulting and Clinical Psychology
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