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JOURNAL ARTICLE
Elizabeth C Stade, Shannon Wiltsey Stirman, Lyle H Ungar, Cody L Boland, H Andrew Schwartz, David B Yaden, João Sedoc, Robert J DeRubeis, Robb Willer, Johannes C Eichstaedt
Large language models (LLMs) such as Open AI's GPT-4 (which power ChatGPT) and Google's Gemini, built on artificial intelligence, hold immense potential to support, augment, or even eventually automate psychotherapy. Enthusiasm about such applications is mounting in the field as well as industry. These developments promise to address insufficient mental healthcare system capacity and scale individual access to personalized treatments. However, clinical psychology is an uncommonly high stakes application domain for AI systems, as responsible and evidence-based therapy requires nuanced expertise...
April 2, 2024: Npj Ment Health Res
#2
JOURNAL ARTICLE
Lorenzo Lorenzo-Luaces, Akash Wasil, Corinne N Kacmarek, Robert DeRubeis
BACKGROUND: There is an ongoing debate about whether digital mental health interventions (DMHIs) can reduce racial and socioeconomic inequities in access to mental health care. A key factor in this debate involves the extent to which racial and ethnic minoritized individuals and socioeconomically disadvantaged individuals are willing to use, and pay for, DMHIs. OBJECTIVE: This study examined racial and ethnic as well as socioeconomic differences in participants' willingness to pay for DMHIs versus one-on-one therapy (1:1 therapy)...
April 11, 2024: JMIR Formative Research
#3
EDITORIAL
Stephen M Schueller, Akash R Wasil, John Bunyi, Robert J DeRubeis, John R Weisz
Mobile apps for mental health and wellness (MH apps) have the potential to support youth mental health, expanding access to the large proportion of youth with mental health concerns who do not access formal treatment. Survey data suggest that young people are highly interested in MH apps, with minoritized youth (eg, LGBTQ individuals) and youth with elevated depressive symptoms reporting especially high rates of downloading MH apps.1 In addition, systematic reviews and meta-analyses suggest that MH apps can be effective...
April 2024: Journal of the American Academy of Child and Adolescent Psychiatry
#4
JOURNAL ARTICLE
Anne-Katharina Deisenhofer, Michael Barkham, Esther T Beierl, Brian Schwartz, Katie Aafjes-van Doorn, Christopher G Beevers, Isabel M Berwian, Simon E Blackwell, Claudi L Bockting, Eva-Lotta Brakemeier, Gary Brown, Joshua E J Buckman, Louis G Castonguay, Claire E Cusack, Tim Dalgleish, Kim de Jong, Jaime Delgadillo, Robert J DeRubeis, Ellen Driessen, Jill Ehrenreich-May, Aaron J Fisher, Eiko I Fried, Jessica Fritz, Toshi A Furukawa, Claire M Gillan, J M Gómez Penedo, Peter F Hitchcock, Stefan G Hofmann, Steven D Hollon, Nicholas C Jacobson, Daniel R Karlin, Chi Tak Lee, Cheri A Levinson, Lorenzo Lorenzo-Luaces, Riley McDanal, Danilo Moggia, Mei Yi Ng, Lesley A Norris, Vikram Patel, Marilyn L Piccirillo, Stephen Pilling, Julian A Rubel, Gonzalo Salazar-de-Pablo, Jessica L Schleider, Paula P Schnurr, Stephen M Schueller, Greg J Siegle, Rudolf Uher, Ed Watkins, Christian A Webb, Shannon Wiltsey Stirman, Laure Wynants, Soo Jeong Youn, Sigal Zilcha-Mano, Wolfgang Lutz, Zachary D Cohen
No abstract text is available yet for this article.
December 1, 2023: Behaviour Research and Therapy
#5
JOURNAL ARTICLE
Elizabeth C Stade, Robert J DeRubeis, Lyle Ungar, Ayelet Meron Ruscio
The current conceptualization of anxiety in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-which includes 11 anxiety disorders plus additional anxiety-related conditions-does not align with accumulating evidence that anxiety is transdiagnostic and dimensional in nature. Transdiagnostic dimensional anxiety models have been proposed, yet they measure anxiety at either a very broad (e.g., "anxiety") or very narrow (e.g., "performance anxiety") level, overlooking intermediate properties of anxiety that cut across DSM disorders...
November 2023: J Psychopathol Clin Sci
#6
JOURNAL ARTICLE
Hongbin Liang, Lin Zhang, Bettina Hoden, Bo Qu, David Derubeis, Xiaotong Song, Dekai Zhang
Toll-like receptors (TLRs) recognize altered gut microbiota triggering an immune response. These responses play a critical role in the pathogenesis and treatment of inflammatory bowel disease (IBD). IBD is characterized by inflammation of the intestinal tracts as in Crohn's disease and ulcerative colitis. However, one challenge in determining the role of a specific TLR in IBD and its underlying mechanism is disparity. Variance in age, gender, race, and ethnicity shows a dramatic difference in the disease incidence, severity, and response to treatment...
2023: Methods in Molecular Biology
#7
REVIEW
Colin Xu, Lucille Miao, Devon Turner, Robert DeRubeis
BACKGROUND: Previous meta-analyses have revealed that in adult and older adult populations of developed countries, depression is more prevalent in urban than rural areas. No meta-analyses have identified the effects of urbanicity on the general age demographic for developing countries. We conducted a meta-analysis of urban-rural differences in depression across all age demographics for developed and developing countries. METHODS: PubMed and PsycINFO databases were searched for studies published between 1980 and 2020...
August 7, 2023: Journal of Affective Disorders
#8
JOURNAL ARTICLE
Suh Jung Park, Akash R Wasil, Sarah Gillespie, Rebecca M Shingleton, John R Weisz, Robert J DeRubeis
BACKGROUND: Mental health problems cause significant distress and impairment in adolescents worldwide. One-fifth of the world's adolescents live in India, and much remains to be known about their mental health and wellbeing. AIM: In this preregistered study, we aimed to estimate the rates of depressive and anxiety symptoms, examine their relationship with indicators of wellbeing, and identify correlates of mental health among Indian adolescents. METHODS: We administered self-report measures of depressive symptoms (PHQ-9), anxiety symptoms (GAD-7), wellbeing (WEMWBS), and happiness (SHS) to 1,213 Indian adolescents (52...
June 2023: Indian Journal of Psychiatry
#9
JOURNAL ARTICLE
Marlene V Strege, John A Richey, Greg J Siegle
BACKGROUND: Theoretical models of neural mechanisms underlying Cognitive Behavior Therapy (CBT) for major depressive disorder (MDD) propose that psychotherapy changes neural functioning of prefrontal cortical structures associated with cognitive-control processes (DeRubeis, Siegle, & Hollon, ); however, MDD is persistent and characterized by long-lasting vulnerabilities to recurrence after intervention, suggesting that underlying neural mechanisms of MDD remain despite treatment. It follows that identification of treatment-resistant aberrant neural processes in MDD may inform clinical and research efforts targeting sustained remission...
May 16, 2023: Psychological Medicine
#10
JOURNAL ARTICLE
Hongbin Liang, Lin Zhang, Ziying Liu, Bettina Hoden, David DeRubeis, Yifan Zhang, Fen Wang, Dekai Zhang
BACKGROUND: Toll-like receptors (TLRs) are the key sensors of innate immunity for triggering immune responses against infections. TLRs are well known to be expressed and activated in innate immune cells, such as macrophage and dendritic cells, but we and others have found that some TLRs are also functional in epithelial cells. However, the role of an epithelial TLR in prostate cancer remains elusive. METHODS: TLR5 expression in messenger RNA and protein level in prostate cancer was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC)...
April 28, 2023: Prostate
#11
JOURNAL ARTICLE
Zachary D Cohen, Robert J DeRubeis, Rachel Hayes, Edward R Watkins, Glyn Lewis, Richard Byng, Sarah Byford, Catherine Crane, Willem Kuyken, Tim Dalgleish, Susanne Schweizer
Depression is highly recurrent, even following successful pharmacological and/or psychological intervention. We aimed to develop clinical prediction models to inform adults with recurrent depression choosing between antidepressant medication (ADM) maintenance or switching to Mindfulness-Based Cognitive Therapy (MBCT). Using data from the PREVENT trial ( N =424), we constructed prognostic models using elastic net regression that combined demographic, clinical and psychological factors to predict relapse at 24 months under ADM or MBCT...
January 2023: Clinical Psychological Science
#12
REVIEW
Bettina Hoden, David DeRubeis, Margarita Martinez-Moczygemba, Kenneth S Ramos, Dekai Zhang
Lung cancer is currently the leading cause of cancer-related deaths worldwide. Significant improvements in lung cancer therapeutics have relied on a better understanding of lung cancer immunity and the development of novel immunotherapies, as best exemplified by the introduction of PD-1/PD-L1-based therapies. However, this improvement is limited to lung cancer patients who respond to anti-PD-1 immunotherapy. Further improvements in immunotherapy may benefit from a better understanding of innate immune response mechanisms in the lung...
2022: Frontiers in Immunology
#13
JOURNAL ARTICLE
Akash R Wasil, Tanvi Malhotra, Nivedita Nandakumar, Sophia Glinski, Avantika Bhatia, Robert J DeRubeis
One goal of clinical psychological science is to help people with problems that matter to them. However, little is known about which kinds of symptoms are viewed as most important, particularly among individuals in non-western settings. We examined the extent to which young adults in India rated individual symptoms of depression and anxiety as important, concerning, and undesirable. Participants were college students at Indian Universities (n = 283). They received a measure of depressive symptoms (Patient Health Questionnaire-9) and anxiety symptoms (Generalized Anxiety Disorder Screener-7)...
September 2022: Behavior Therapy
#14
JOURNAL ARTICLE
Keith Bredemeier, Sadie Larsen, Geetha Shivakumar, Kathleen Grubbs, Carmen McLean, Carmella Tress, David Rosenfield, Rob DeRubeis, Colin Xu, Edna Foa, Leslie Morland, Anushka Pai, Carol Tsao, Jaclyn Crawford, Erica Weitz, Lindiwe Mayinja, Bridget Feler, Tamara Wachsman, Margaret Lupo, Vaughan Hooper, Riley Cook, Michael Thase
BACKGROUND: Several efficacious psychological and pharmacological treatments for posttraumatic stress disorder (PTSD) are available; however, the comparative effectiveness of these treatments represents a major gap in the literature. The proposed study will compare the effectiveness of two leading PTSD treatments - Prolonged Exposure (PE) therapy and pharmacotherapy with paroxetine or venlafaxine extended release - as well as the combination of PE and medication. METHODS: In a randomized clinical trial, veterans with PTSD (N = 450) recruited across six Veterans Affairs Medical Centers will complete assessments at baseline, mid-treatment (Week 7), post-treatment (Week 14), and follow-up (Weeks 27 and 40)...
August 2022: Contemporary Clinical Trials
#15
JOURNAL ARTICLE
Moira A Visovatti, Mi Sook Jung, Heidi Mason, Mary Beth DeRubeis, Francis P Worden, Debra L Barton
BACKGROUND: Head and neck cancer (HNC) and associated treatments have significant long-term and late adverse effects that can impair function. Therefore, there is a need for reliable common metrics to assess function in HNC that limit participant burden and are cost-effective and easy to use in clinical settings. OBJECTIVE: The aim of this study was to assess the feasibility of using the Fitbit Zip, NIH Toolbox, and REDCap electronic data collection tool to measure function and symptoms in individuals with HNC and to explore preliminary findings...
January 12, 2022: Cancer Nursing
#16
JOURNAL ARTICLE
Rob Saunders, Zachary D Cohen, Gareth Ambler, Robert J DeRubeis, Nicola Wiles, David Kessler, Simon Gilbody, Steve D Hollon, Tony Kendrick, Ed Watkins, David Richards, Sally Brabyn, Elizabeth Littlewood, Debbie Sharp, Glyn Lewis, Steve Pilling, Joshua E J Buckman
BACKGROUND: Subgrouping methods have the potential to support treatment decision making for patients with depression. Such approaches have not been used to study the continued course of depression or likelihood of relapse following treatment. METHOD: Data from individual participants of seven randomised controlled trials were analysed. Latent profile analysis was used to identify subgroups based on baseline characteristics. Associations between profiles and odds of both continued chronic depression and relapse up to one year post-treatment were explored...
December 4, 2021: Journal of Personalized Medicine
#17
JOURNAL ARTICLE
Colin Xu, Haley Gelberg, Robert J DeRubeis
BACKGROUND AND OBJECTIVES: Research has shown that state emotion can affect emotion regulation strategies in healthy samples. Emotion regulation plays an important role in depression. We hypothesized that for depressed individuals, experiencing anxiety or anger affects emotion regulation strategy use differently than experiencing sadness. DESIGN AND METHODS: Individuals diagnosed with chronic or recurrent depression ( N = 386) responded to vignettes of hypothetical stressors and reported their state emotions and emotion regulation strategies in a thought-listing procedure...
December 19, 2021: Anxiety, Stress, and Coping
#18
REVIEW
Dr Joshua E J Buckman, Rob Saunders, Laura-Louise Arundell, Iyinoluwa D Oshinowo, Zachary D Cohen, Ciaran O'Driscoll, Phoebe Barnett, Joshua Stott, Gareth Ambler, Prof Simon Gilbody, Prof Steven D Hollon, Prof Tony Kendrick, Prof Edward Watkins, Prof Thalia C Eley, Megan Skelton, Prof Nicola Wiles, Prof David Kessler, Prof Robert J DeRubeis, Prof Glyn Lewis, Prof Stephen Pilling
OBJECTIVE: To investigate associations between major life events and prognosis independent of treatment type: 1) after adjusting for clinical prognostic factors and socio-demographics; 2) among patients with depressive episodes at least six-months long; and 3) patients with a first life-time depressive episode. METHODS: Six RCTs of adults seeking treatment for depression in primary care met eligibility criteria, individual patient data (IPD) were collated from all six (n=2858)...
December 14, 2021: Journal of Affective Disorders
#19
RANDOMIZED CONTROLLED TRIAL
Jaime Delgadillo, Shehzad Ali, Kieran Fleck, Charlotte Agnew, Amy Southgate, Laura Parkhouse, Zachary D Cohen, Robert J DeRubeis, Michael Barkham
Importance: Depression is a major cause of disability worldwide. Although empirically supported treatments are available, there is scarce evidence on how to effectively personalize psychological treatment selection. Objective: To compare the clinical effectiveness and cost-effectiveness of 2 treatment selection strategies: stepped care and stratified care. Design, Setting, and Participants: This multisite, cluster randomized clinical trial recruited participants from the English National Health Service from July 5, 2018, to February 1, 2019...
February 1, 2022: JAMA Psychiatry
#20
JOURNAL ARTICLE
Akash R Wasil, Sarah Gillespie, Suh Jung Park, Katherine E Venturo-Conerly, Tom L Osborn, Robert J DeRubeis, John R Weisz, Payton J Jones
BACKGROUND: Network analyses have been applied to understand the relationships between individual symptoms of depression and anxiety. However, little is known about which symptoms are most strongly associated with "positive" indicators of mental health, such as happiness. Furthermore, few studies have examined symptom networks in participants from low- and middle-income countries. METHODS: To address these gaps, we applied network analyses in a sample of Indian adolescents (Study 1; n=1080) and replicated these analyses in a pre-registered study with Kenyan adolescents (Study 2; n=2176)...
December 1, 2021: Journal of Affective Disorders
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